Detailed information for compound 1145480

Basic information

Technical information
  • TDR Targets ID: 1145480
  • Name: 2-(5-carbamimidoyl-1-benzothiophen-3-yl)-3-ph enyl-N-[4-(4-phenylimidazol-1-yl)phenyl]propa namide
  • MW: 541.665 | Formula: C33H27N5OS
  • H donors: 2 H acceptors: 2 LogP: 6.08 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(C(c1csc2c1cc(cc2)C(=N)N)Cc1ccccc1)Nc1ccc(cc1)n1cnc(c1)c1ccccc1
  • InChi: 1S/C33H27N5OS/c34-32(35)24-11-16-31-27(18-24)29(20-40-31)28(17-22-7-3-1-4-8-22)33(39)37-25-12-14-26(15-13-25)38-19-30(36-21-38)23-9-5-2-6-10-23/h1-16,18-21,28H,17H2,(H3,34,35)(H,37,39)
  • InChiKey: SFQJXKKBEULZHT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(5-carbamimidoylbenzothiophen-3-yl)-3-phenyl-N-[4-(4-phenylimidazol-1-yl)phenyl]propanamide
  • 2-(5-carbamimidoyl-3-benzothiophenyl)-3-phenyl-N-[4-(4-phenyl-1-imidazolyl)phenyl]propanamide
  • 2-(5-amidinobenzothiophen-3-yl)-3-phenyl-N-[4-(4-phenylimidazol-1-yl)phenyl]propionamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ran 0.0021 0.0012 0.0052
Brugia malayi DKFZp564C0469 protein 0.002 0.0011 0.0131
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0003 0.0032
Mycobacterium tuberculosis Conserved protein 0.0074 0.0204 0.0204
Brugia malayi Pax transcription activation domain interacting protein 0.002 0.0011 0.0131
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0023 0.1113
Entamoeba histolytica hypothetical protein 0.0146 0.0462 0.6903
Echinococcus multilocularis muscleblind protein 1 0.0146 0.0459 0.0522
Brugia malayi beta-lactamase 0.0074 0.0204 0.2485
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0039 0.1918
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0204 1
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.002 0.0011 0.0122
Brugia malayi Importin beta-1 subunit 0.0028 0.0039 0.0477
Loa Loa (eye worm) MBCTL1 0.0054 0.0133 0.13
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0012 0.015
Loa Loa (eye worm) hypothetical protein 0.0124 0.0383 0.3753
Plasmodium falciparum importin beta, putative 0.0028 0.0039 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0068 0.0282
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0007 0.0344
Mycobacterium tuberculosis Conserved protein 0.0074 0.0204 0.0204
Echinococcus granulosus Protein patched homolog 1 0.0088 0.0251 0.1048
Schistosoma mansoni DNA ligase IV 0.002 0.0011 0.0045
Loa Loa (eye worm) hypothetical protein 0.0124 0.0383 0.3753
Entamoeba histolytica hypothetical protein 0.002 0.0011 0.0122
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0204 0.8118
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0068 0.2617
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0031 0.1508
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0226 0.0747 0.7312
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0078 0.0218 0.0247
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.013 0.158
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0003 0.0131
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0204 0.8118
Schistosoma mansoni topbp1 0.002 0.0011 0.0045
Brugia malayi intermediate filament protein 0.0054 0.013 0.158
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0068 0.0077
Brugia malayi Calcitonin receptor-like protein seb-1 0.0247 0.0823 1
Brugia malayi latrophilin 2 splice variant baaae 0.0169 0.0543 0.6596
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0012 0.015
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0023 0.0618
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0054 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0012 0.015
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0204 0.0204
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.015 0.0625
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0023 0.1113
Trichomonas vaginalis ran, putative 0.0021 0.0012 0.0392
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0012 0.0014
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0012 0.015
Onchocerca volvulus 0.0048 0.0109 0.2638
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0028 0.1381
Echinococcus granulosus nibrin 0.002 0.0011 0.0045
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0003 0.0131
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.0121
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0476 0.1642 0.1642
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0012 0.0051
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0204 0.0853
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0012 0.0121
Giardia lamblia Replication factor C, subunit 1 0.002 0.0011 0.8321
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0106
Brugia malayi Cytochrome P450 family protein 0.0026 0.0031 0.0375
Onchocerca volvulus 0.0074 0.0204 0.5201
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0106
Schistosoma mansoni hypothetical protein 0.0084 0.024 0.1001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0012 0.0051
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.0121
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0023 0.4211
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0012 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0012 0.0014
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0011 0.0326
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0204 0.0204
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0028 0.0902
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0159 0.018
Loa Loa (eye worm) hypothetical protein 0.0204 0.0668 0.6544
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.024 0.0272
Onchocerca volvulus 0.0054 0.013 0.32
Brugia malayi steroid hormone receptor 0.0021 0.0012 0.015
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0011 0.0527
Loa Loa (eye worm) hypothetical protein 0.0074 0.0204 0.2002
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0012 0.0042
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0133 0.0554
Brugia malayi beta-lactamase family protein 0.0074 0.0204 0.2485
Schistosoma mansoni importin beta-1 0.0028 0.0039 0.0164
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.0121
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0012 0.0051
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0159 0.0663
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0141
Echinococcus granulosus Niemann Pick C1 protein 0.0204 0.0668 0.2787
Echinococcus multilocularis nibrin 0.002 0.0011 0.0012
Onchocerca volvulus 0.0074 0.0204 0.5201
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0204 0.0204
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0007 0.0344
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0106
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.013 0.1273
Brugia malayi Receptor family ligand binding region containing protein 0.0022 0.0015 0.0184
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0068 0.2617
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0012 0.0051
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0027 0.0112
Leishmania major DNA polymerase kappa, putative 0.0019 0.0007 0.0344
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.015 0.7326
Brugia malayi hypothetical protein 0.002 0.0011 0.0131
Echinococcus multilocularis lamin 0.0054 0.013 0.0148
Mycobacterium ulcerans lipase LipD 0.0074 0.0204 0.0204
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0022 0.0015 0.0148
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0068 0.3312
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0106
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0344
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0326
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0068 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0012 0.015
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0011 0.0527
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0012 0.0051
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0039 0.1918
Loa Loa (eye worm) hypothetical protein 0.0074 0.0204 0.2002
Loa Loa (eye worm) beta-lactamase 0.0074 0.0204 0.2002
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0109 0.0455
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0189 0.0613 0.2555
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0078 0.0218 0.0908
Echinococcus multilocularis protein dispatched 1 0.01 0.0296 0.0335
Echinococcus multilocularis expressed conserved protein 0.0192 0.0624 0.0708
Schistosoma mansoni transcription factor LCR-F1 0.0146 0.0462 0.1927
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0012 0.0014
Mycobacterium ulcerans beta-lactamase 0.0074 0.0204 0.0204
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0031 0.0031
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0007 0.0029
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0068 0.3312
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0146 0.0462 0.1927
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0007 0.0029
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.002 0.0979
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0012 0.0607
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0012 0.0014
Loa Loa (eye worm) hypothetical protein 0.0025 0.0027 0.0264
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0028 0.1381
Schistosoma mansoni metabotropic glutamate receptor 0.0041 0.0085 0.0354
Echinococcus multilocularis sterol regulatory element binding protein 0.0088 0.0251 0.0285
Loa Loa (eye worm) hypothetical protein 0.0025 0.0027 0.0264
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0344
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0012 0.0014
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0012 0.0051
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0011 0.0326
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0007 0.0007
Echinococcus multilocularis musashi 0.0054 0.013 0.0148
Loa Loa (eye worm) RNA binding protein 0.0062 0.0159 0.1557
Schistosoma mansoni hypothetical protein 0.0084 0.024 0.1001
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0012 0.0051
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.0121
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0007 0.0007
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0247 0.0823 0.8056
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0011 0.0326
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0012 0.0607
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.015 0.015
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.015 0.0625
Loa Loa (eye worm) hypothetical protein 0.0022 0.0015 0.0148
Schistosoma mansoni hypothetical protein 0.0047 0.0107 0.0448
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0007 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0344
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0007 0.0344
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0012 0.0121
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0003 0.0131
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0159 0.1557
Schistosoma mansoni hypothetical protein 0.0084 0.024 0.1001
Schistosoma mansoni coup transcription factor 0.0021 0.0012 0.0051
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0068 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0133 0.0151
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0068 0.0977
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.015 0.015
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.002 0.0011 0.0527
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0247 0.0823 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0159 0.0663
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0012 0.015
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0007 0.0344
Echinococcus granulosus dna polymerase eta 0.0019 0.0007 0.0029
Mycobacterium tuberculosis Conserved protein 0.0074 0.0204 0.0204
Onchocerca volvulus Huntingtin homolog 0.0124 0.0383 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0068 0.2617
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0133 0.0554
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0023 0.0023
Loa Loa (eye worm) latrophilin receptor protein 2 0.0078 0.0218 0.2132
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0028 0.1381
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0003 0.0011
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0007 0.0029
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0012 0.015
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0027 0.1317
Toxoplasma gondii ABC1 family protein 0.0074 0.0204 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0012 0.015
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0088 0.0251 0.246
Echinococcus multilocularis muscleblind protein 0.0146 0.0459 0.0522
Plasmodium vivax importin-beta 2, putative 0.0028 0.0039 0.1468
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0326
Onchocerca volvulus 0.0021 0.0012 0.0042
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0133 0.0554
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0109 0.0124
Loa Loa (eye worm) hypothetical protein 0.0074 0.0204 0.2002
Echinococcus granulosus muscleblind protein 0.0146 0.0459 0.1916
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0012 0.0084
Loa Loa (eye worm) hypothetical protein 0.0074 0.0204 0.2002
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.0134 0.1315
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0204 0.8118
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0204 0.0232
Echinococcus multilocularis dna polymerase eta 0.0019 0.0007 0.0008
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0068 0.3312
Brugia malayi Inositol-1 0.0036 0.0068 0.0823
Echinococcus granulosus lamin 0.0054 0.013 0.0542
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0003 0.0011
Leishmania major hypothetical protein, conserved 0.0074 0.0204 1
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0039 0.0045
Schistosoma mansoni hypothetical protein 0.0078 0.0218 0.0908
Trypanosoma cruzi FHA domain containing protein, putative 0.002 0.0011 0.0527
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0012 0.0051
Echinococcus multilocularis snurportin 1 0.0303 0.1021 0.1159
Brugia malayi hypothetical protein 0.0124 0.0383 0.4658
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0003 0.0131
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0344
Loa Loa (eye worm) hypothetical protein 0.0074 0.0204 0.2002
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0012 0.0051
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0106
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0012 0.015
Leishmania major DNA polymerase eta, putative 0.0019 0.0007 0.0344
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0344
Loa Loa (eye worm) hypothetical protein 0.0054 0.013 0.1273
Loa Loa (eye worm) hypothetical protein 0.0084 0.024 0.2351
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0012 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0344
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.024 0.2918
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0014 0.0706
Leishmania major importin beta-1 subunit, putative 0.0023 0.002 0.0979
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0012 0.015
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0109 0.0455
Giardia lamblia DINP protein human, muc B family 0.0019 0.0007 0.4472
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0007 0.0085
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0344
Schistosoma mansoni hypothetical protein 0.0084 0.024 0.1001
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0011 0.0527
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.0436 0.0495
Echinococcus multilocularis Niemann Pick C1 protein 0.0204 0.0668 0.0759
Loa Loa (eye worm) intermediate filament protein 0.0054 0.013 0.1273
Mycobacterium ulcerans AcrR family transcriptional regulator 0.281 1 1
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0031 0.1508
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0023 0.1113
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0109 0.1068
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0146 0.0462 0.0525
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0189 0.0613 0.0696
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0031 0.0302
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0031 0.0035
Schistosoma mansoni hypothetical protein 0.0078 0.0218 0.0908
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0204 0.8118
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0007 0.0175
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0023 0.0023
Brugia malayi Cytochrome P450 family protein 0.0055 0.0134 0.1633
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.0436 0.4273
Schistosoma mansoni hypothetical protein 0.0146 0.0462 0.1927
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.0121
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0076 0.0211 0.2568
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0007 0.0008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0436 0.182
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0071 0.0191 0.0216
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0003 0.0003
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.002 0.0011 0.0131
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0204 1
Echinococcus granulosus intermediate filament protein 0.0054 0.013 0.0542
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.015 0.015
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0372 0.3641
Leishmania major hypothetical protein, conserved 0.0025 0.0028 0.1381
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0007 0.0344
Brugia malayi RNA binding protein 0.0062 0.0159 0.1932
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0027 0.0031
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0003 0.0131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0012 0.0121
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0109 0.0124
Brugia malayi Metabotropic glutamate receptor precursor. 0.0084 0.024 0.2913
Entamoeba histolytica hypothetical protein 0.0023 0.002 0.0261
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0012 0.015
Schistosoma mansoni hypothetical protein 0.0687 0.2398 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0326
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0007 0.0007
Brugia malayi Niemann-Pick C1 protein precursor 0.0204 0.0668 0.8123
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0041 0.0399
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0012 0.0051
Brugia malayi hypothetical protein 0.0146 0.0462 0.5617
Loa Loa (eye worm) glutamate receptor 0.0084 0.024 0.2347
Schistosoma mansoni ran 0.0021 0.0012 0.0052
Brugia malayi topoisomerase 0.002 0.0011 0.0131
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0133 0.1613
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0012 0.0051
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0204 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0007 0.0008
Echinococcus granulosus lamin dm0 0.0054 0.013 0.0542
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0012 0.0042
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0109 0.0455
Loa Loa (eye worm) hypothetical protein 0.0074 0.0204 0.2002
Trypanosoma brucei unspecified product 0.0019 0.0007 0.0344
Schistosoma mansoni intermediate filament proteins 0.0054 0.013 0.0542
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0003 0.0131
Echinococcus multilocularis Niemann Pick C1 protein 0.0292 0.0982 0.1115
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0007 0.0344
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0012 0.0042
Brugia malayi beta-lactamase family protein 0.0074 0.0204 0.2485
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0003 0.0137
Brugia malayi follicle stimulating hormone receptor 0.0226 0.0747 0.9076
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0372 0.3641
Leishmania major cytochrome p450-like protein 0.0026 0.0031 0.1508
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0028 0.1381
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.077 0.0874
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0027 0.0976
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0078 0.0218 0.0908
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0106
Onchocerca volvulus Huntingtin homolog 0.0124 0.0383 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0159 0.1557
Loa Loa (eye worm) hypothetical protein 0.0232 0.077 0.7541
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0007 0.0175
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0436 0.182
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0012 0.0051
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0012 0.0051
Loa Loa (eye worm) hypothetical protein 0.0025 0.0028 0.0277
Brugia malayi RNA, U transporter 1 0.0081 0.0226 0.2751
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0023 0.1113
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0003 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0326
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0012 0.015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0012 0.0121
Echinococcus multilocularis geminin 0.0687 0.2398 0.2722
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0007 0.0344
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0109 0.2638
Mycobacterium ulcerans TetR family transcriptional regulator 0.281 1 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0011 0.0326
Mycobacterium ulcerans hypothetical protein 0.0074 0.0204 0.0204
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0204 0.0853
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0012 0.015
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0012 0.0151
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.0436 0.182
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0011 0.0527
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0007 0.0069
Echinococcus granulosus expressed conserved protein 0.0192 0.0624 0.2602
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.002 0.0011 0.0011
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0012 0.0121
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.0436 0.182
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0204 0.0204
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.0436 0.0495
Schistosoma mansoni topbp1 0.002 0.0011 0.0045
Echinococcus granulosus metabotropic glutamate receptor 2 0.0071 0.0191 0.0795
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0003 0.0131
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0003 0.0026
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0012 0.0014
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0159 0.0663
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0003 0.0131
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0012 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0012 0.015
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0003 0.0032
Entamoeba histolytica hypothetical protein 0.0024 0.0023 0.0302
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0204 0.0204
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0344
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0003 0.0131
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0041 0.0495
Echinococcus granulosus sterol regulatory element binding protein 0.0088 0.0251 0.1048
Toxoplasma gondii ATPase, AAA family protein 0.002 0.0011 0.0527
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2477 0.881 1
Trichomonas vaginalis replication factor C large subunit, putative 0.002 0.0011 0.0326
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0012 0.0051
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0107 0.1306
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0012 0.0121
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.1021 1
Trichomonas vaginalis esterase, putative 0.0074 0.0204 0.8118
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0003 0.0131
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0003 0.0137
Onchocerca volvulus 0.0047 0.0107 0.2597
Schistosoma mansoni survival motor neuron protein 0.0047 0.0107 0.0448
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0027 0.0112
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.015 0.017
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.015 0.015
Onchocerca volvulus 0.0074 0.0204 0.5201
Schistosoma mansoni hypothetical protein 0.0078 0.0218 0.0908
Loa Loa (eye worm) hypothetical protein 0.0028 0.0039 0.0384
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0159 0.0663
Loa Loa (eye worm) hypothetical protein 0.0088 0.0251 0.246
Mycobacterium leprae Probable lipase LipE 0.0074 0.0204 0.0204
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0023 1
Trichomonas vaginalis importin beta-1, putative 0.0023 0.002 0.0698
Echinococcus multilocularis GPCR, family 2 0.0078 0.0218 0.0247
Schistosoma mansoni patched 1 0.0088 0.0251 0.1048
Brugia malayi hypothetical protein 0.0232 0.077 0.936
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0028 0.6143
Echinococcus granulosus metabotropic glutamate receptor 5 0.0104 0.0309 0.129
Loa Loa (eye worm) hypothetical protein 0.0104 0.0309 0.303
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0012 0.0575
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0012 0.0051
Echinococcus granulosus snurportin 1 0.0303 0.1021 0.4259
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0031 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0326
Brugia malayi TAR-binding protein 0.0062 0.0159 0.1932
Brugia malayi CHE-14 protein 0.0088 0.0251 0.3054
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0204 0.0853
Brugia malayi hypothetical protein 0.0025 0.0028 0.0343
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0204 0.0204
Loa Loa (eye worm) inositol-1 0.0036 0.0068 0.0663
Brugia malayi nuclear receptor NHR-88 0.0021 0.0012 0.015
Schistosoma mansoni lamin 0.0054 0.013 0.0542
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.002 0.0698
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0204 0.0204
Entamoeba histolytica hypothetical protein 0.0146 0.0462 0.6903
Echinococcus multilocularis protein patched 0.0088 0.0251 0.0285
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0096 0.0281 0.1172
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0159 0.0663
Brugia malayi hypothetical protein 0.002 0.0011 0.0131
Schistosoma mansoni hypothetical protein 0.0687 0.2398 1
Schistosoma mansoni hypothetical protein 0.0291 0.0979 0.4083
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0251 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.024 0.1001
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0204 0.8118
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0012 0.0051
Echinococcus granulosus GPCR family 2 0.0078 0.0218 0.0908
Schistosoma mansoni hypothetical protein 0.0169 0.0543 0.2263
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0012 0.0121
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0204 1
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.015 0.0625
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0027 0.1317
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0007 0.0085
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0027 0.1317
Loa Loa (eye worm) hypothetical protein 0.0169 0.0543 0.5314
Echinococcus multilocularis lamin dm0 0.0054 0.013 0.0148
Brugia malayi metabotropic glutamate receptor type 2 0.0041 0.0085 0.1032
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0003 0.0131
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0159 0.1932
Loa Loa (eye worm) hypothetical protein 0.0078 0.0218 0.2132
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0068 0.3312
Schistosoma mansoni metabotropic glutamate receptor 0.0071 0.0191 0.0795
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0344
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0012 0.015
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0023 0.0023
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0204 0.0204
Schistosoma mansoni inositol monophosphatase 0.0036 0.0068 0.0282
Loa Loa (eye worm) hypothetical protein 0.0054 0.0133 0.13
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.0436 0.5304
Entamoeba histolytica hypothetical protein 0.0146 0.0462 0.6903
Brugia malayi MH2 domain containing protein 0.0121 0.0372 0.452
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0068 0.0282
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0031 0.1508
Onchocerca volvulus 0.0054 0.013 0.32
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0007 0.0344
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0204 0.0204
Echinococcus granulosus replication factor c subunit 1 0.002 0.0011 0.0045
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0133 0.0151
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0023 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0207 0.068 0.2834
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0003 0.0131
Brugia malayi mbt repeat family protein 0.0048 0.0109 0.1325
Echinococcus granulosus geminin 0.0687 0.2398 1
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0039 0.1918
Brugia malayi Muscleblind-like protein 0.0146 0.0459 0.5585
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0012 0.015
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.281 1 1
Entamoeba histolytica Ran family GTPase 0.0021 0.0012 0.0146
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.015 0.7326
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0012 0.0607
Echinococcus granulosus dna polymerase kappa 0.0019 0.0007 0.0029
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0104 0.0309 0.0351
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0012 0.0014
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0109 0.0455
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0012 0.0052
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0204 0.2002
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0023 0.2103
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0031 0.0302
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0078 0.0218 0.0247
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0068 0.3312
Schistosoma mansoni DNA polymerase eta 0.0019 0.0007 0.0029
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.077 0.3211
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0022 0.0015 0.0148
Loa Loa (eye worm) hypothetical protein 0.0146 0.0459 0.4499
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0204 0.0668 1
Echinococcus multilocularis replication factor c subunit 1 0.002 0.0011 0.0012
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0007 0.0344
Loa Loa (eye worm) hypothetical protein 0.0053 0.0126 0.1238
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0007 0.0344
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0204 0.0204
Brugia malayi Latrophilin receptor protein 2 0.0078 0.0218 0.2647
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.024 0.1001
Onchocerca volvulus 0.0084 0.024 0.6156
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0012 0.0014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0436 0.182
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0003 0.0131
Brugia malayi ecdysteroid receptor 0.0021 0.0012 0.015
Leishmania major GTP-binding protein, putative 0.0021 0.0012 0.0607
Entamoeba histolytica hypothetical protein 0.0025 0.0027 0.0364
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0003 0.0131
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0109 0.0455
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0003 0.0003
Schistosoma mansoni lamin 0.0054 0.013 0.0542
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0003 0.0011
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0003 0.0026
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0012 0.0014
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0299
Brugia malayi Cytochrome P450 family protein 0.0026 0.0031 0.0375
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.0121
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0012 0.0051
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0012 0.0014
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0012 0.0051
Entamoeba histolytica hypothetical protein 0.0146 0.0462 0.6903
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0054 0.0054
Schistosoma mansoni chromosome transmission fidelity factor 0.002 0.0011 0.0045
Echinococcus granulosus Niemann Pick C1 protein 0.0292 0.0982 0.4094
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0003 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0007 0.0344
Echinococcus granulosus importin subunit beta 1 0.0028 0.0039 0.0164
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0078 0.0218 0.2647
Loa Loa (eye worm) hypothetical protein 0.0247 0.0823 0.8056
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0012 0.0122
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0012 0.0121
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.002 0.0698
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0028 0.6143
Schistosoma mansoni hypothetical protein 0.0078 0.0218 0.0908
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0204 0.2485
Mycobacterium ulcerans transcriptional regulator 0.281 1 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.0459 0.4499
Brugia malayi nuclear hormone receptor 0.0021 0.0012 0.015
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0007 0.0065
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.002 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0107 0.0322 0.3151
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0031 0.0302
Loa Loa (eye worm) glutamate receptor 0.0033 0.0056 0.0553
Schistosoma mansoni hypothetical protein 0.0303 0.1021 0.4259
Loa Loa (eye worm) hypothetical protein 0.0048 0.0109 0.1068
Echinococcus granulosus tar DNA binding protein 0.0062 0.0159 0.0663
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0012 0.0051
Brugia malayi mbt repeat family protein 0.0048 0.0109 0.1325
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0003 0.0131
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0027 0.0327
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.0121
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0012 0.0607

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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