TDR Targets

Basic information

Technical information

TDR Targets ID: 1157425
Name: 2-(3,7-dimethyl-2,6-dioxopurin-1-yl)ethyl (hy droxy-phosphonooxyphosphoryl) hydrogen phosph ate
MW: 464.156 | Formula: C9H15N4O12P3
H donors: 4 H acceptors: 10 LogP: -4.4 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=c1n(CCOP(=O)(OP(=O)(OP(=O)(O)O)O)O)c(=O)c2c(n1C)ncn2C
InChi: 1S/C9H15N4O12P3/c1-11-5-10-7-6(11)8(14)13(9(15)12(7)2)3-4-23-27(19,20)25-28(21,22)24-26(16,17)18/h5H,3-4H2,1-2H3,(H,19,20)(H,21,22)(H2,16,17,18)
InChiKey: GZILPRLWMIKLFR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(3,7-dimethyl-2,6-dioxo-purin-1-yl)ethyl (hydroxy-phosphonooxy-phosphoryl) hydrogen phosphate
2-(3,7-dimethyl-2,6-dioxo-1-purinyl)ethyl (hydroxy-phosphonooxyphosphoryl) hydrogen phosphate
2-(2,6-diketo-3,7-dimethyl-purin-1-yl)ethyl (hydroxy-phosphonooxy-phosphoryl) hydrogen phosphate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0175	0.027	0.0317
Schistosoma mansoni	hypothetical protein	0.0027	0.0008	0.001
Mycobacterium ulcerans	non-ribosomal peptide synthetase	0.0028	0.001	0.0008
Trypanosoma cruzi	GDP-mannose pyrophosphorylase	0.0029	0.001	0.0186
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.0049	0.0915
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0148	0.0709
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0023	0.0427
Schistosoma mansoni	sex comb on midleg homolog	0.005	0.0048	0.0057
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0105	0.0145	0.0143
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0023	0.0021
Toxoplasma gondii	GDP-D-mannose pyrophosphorylase	0.0029	0.001	0.0014
Leishmania major	hypothetical protein, conserved	0.0036	0.0023	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0047	0.0219
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0023	0.0501
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0047	0.0042	0.065
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0008	0.0166
Echinococcus granulosus	microtubule associated protein 2	0.4823	0.8495	1
Brugia malayi	mbt repeat family protein	0.005	0.0048	0.0222
Loa Loa (eye worm)	nucleotidyl transferase	0.0029	0.001	0.004
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0069	0.1164
Brugia malayi	MH2 domain containing protein	0.0081	0.0103	0.049
Echinococcus granulosus	mothers against decapentaplegic 6	0.0036	0.0024	0.0028
Trypanosoma brucei	GDP-mannose pyrophosphorylase	0.0029	0.001	0.0045
Mycobacterium ulcerans	transferase	0.0027	0.0008	0.0006
Schistosoma mansoni	hypothetical protein	0.0175	0.027	0.0317
Loa Loa (eye worm)	pip kinase 2	0.0157	0.0238	0.1144
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.005	0.0048	0.0057
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0047	0.0042	0.8289
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0023	0.0021
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0023	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0023	0.0102
Echinococcus granulosus	GPCR family 2	0.0175	0.027	0.0317
Plasmodium vivax	thioredoxin reductase, putative	0.0046	0.0041	0.7974
Loa Loa (eye worm)	dynactin 5	0.0027	0.0008	0.0029
Entamoeba histolytica	acetyltransferase, putative	0.0027	0.0008	0.0219
Trypanosoma cruzi	cruzipain precursor, putative	0.0062	0.0069	0.1289
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0553	0.0939	0.454
Giardia lamblia	Translation initiation factor	0.0027	0.0008	0.5
Entamoeba histolytica	ankyrin, putative	0.0027	0.0008	0.0219
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0116	0.0166	0.0164
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0023	0.3687
Schistosoma mansoni	hypothetical protein	0.0687	0.1175	0.1383
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.032	0.0526	0.0619
Mycobacterium ulcerans	lipase LipD	0.0036	0.0023	0.0021
Brugia malayi	RNA binding protein	0.0061	0.0068	0.0321
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0023	0.0027
Echinococcus multilocularis	SAM and MBT domain containing protein	0.005	0.0048	0.0057
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0081	0.0103	0.0122
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.032	0.0526	0.0619
Trypanosoma cruzi	serine acetyltransferase, putative	0.0027	0.0008	0.0142
Entamoeba histolytica	hypothetical protein	0.0218	0.0346	1
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0046	0.0041	0.0752
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0047	0.0042	0.005
Entamoeba histolytica	serine acetyltransferase 1	0.0027	0.0008	0.0219
Mycobacterium tuberculosis	Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU	0.5673	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0069	0.1164
Brugia malayi	hypothetical protein	0.0051	0.0049	0.0229
Brugia malayi	mbt repeat family protein	0.005	0.0048	0.0222
Loa Loa (eye worm)	intermediate filament protein	0.0107	0.0148	0.0709
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0047	0.0042	0.005
Entamoeba histolytica	serine acetyltransferase 1	0.0027	0.0008	0.0219
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0023	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0047	0.0219
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0218	0.0346	0.0408
Leishmania major	trypanothione reductase	0.0046	0.0041	0.0758
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0069	0.1289
Onchocerca volvulus		0.0107	0.0148	0.6198
Schistosoma mansoni	hypothetical protein	0.0303	0.0496	0.0583
Echinococcus granulosus	phosphatidylinositol 5 phosphate 4 kinase type 2	0.0157	0.0238	0.028
Loa Loa (eye worm)	hypothetical protein	0.0028	0.001	0.0038
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.0049	0.0915
Echinococcus granulosus	mothers against decapentaplegic 2	0.0036	0.0024	0.0028
Mycobacterium tuberculosis	Probable reductase	0.0105	0.0145	0.0143
Echinococcus multilocularis	tumor protein p63	0.0693	0.1187	0.1397
Brugia malayi	RNA recognition motif domain containing protein	0.0061	0.0068	0.0321
Schistosoma mansoni	lamin	0.0107	0.0148	0.0175
Schistosoma mansoni	smad	0.0081	0.0103	0.0122
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.02	0.0314	0.037
Brugia malayi	MH2 domain containing protein	0.0036	0.0024	0.0105
Loa Loa (eye worm)	helix-loop-helix DNA-binding domain-containing protein	0.0106	0.0147	0.0701
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.02	0.0314	0.037
Brugia malayi	Latrophilin receptor protein 2	0.0175	0.027	0.1296
Brugia malayi	RNA, U transporter 1	0.0081	0.0103	0.0486
Entamoeba histolytica	bacterial transferase hexapeptide family protein	0.0027	0.0008	0.0219
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.005	0.0048	0.1941
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0002	0.0032
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0023	0.0021
Schistosoma mansoni	gdp-mannose pyrophosphorylase b isoform 2	0.0029	0.001	0.0012
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0116	0.0166	0.0164
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0175	0.027	0.1296
Leishmania major	cathepsin L-like protease	0.0062	0.0069	0.1289
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0023	0.0021
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0149	0.0224	0.0264
Schistosoma mansoni	transcription factor LCR-F1	0.0218	0.0346	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0155	0.0234	0.1122
Entamoeba histolytica	maltose O-acetyltransferase, putative	0.0027	0.0008	0.0219
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.032	0.0526	0.0619
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0023	0.0021
Schistosoma mansoni	hypothetical protein	0.0099	0.0136	0.016
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0047	0.0042	0.0783
Echinococcus multilocularis	musashi	0.0107	0.0148	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0238	0.1144
Brugia malayi	hypothetical protein	0.0487	0.0821	0.3971
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0081	0.0103	0.0122
Trichomonas vaginalis	maltose O-acetyltransferase, putative	0.0027	0.0008	0.0166
Entamoeba histolytica	maltose O-acetyltransferase, putative	0.0027	0.0008	0.0219
Entamoeba histolytica	hypothetical protein	0.0218	0.0346	1
Brugia malayi	Importin beta-1 subunit	0.0028	0.001	0.0038
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0116	0.0166	0.0164
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0039	0.0179
Loa Loa (eye worm)	Smad1	0.0081	0.0103	0.049
Schistosoma mansoni	hypothetical protein	0.0307	0.0503	0.0592
Plasmodium falciparum	ataxin-2 like protein, putative	0.0051	0.0049	1
Brugia malayi	Helix-loop-helix DNA-binding domain containing protein	0.0106	0.0148	0.0705
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0008	0.0029
Brugia malayi	Pip kinase protein 2	0.0157	0.0238	0.1144
Echinococcus multilocularis	survival motor neuron protein 1	0.0487	0.0821	0.0967
Mycobacterium tuberculosis	Possible siderophore-binding protein	0.0027	0.0008	0.0006
Brugia malayi	beta-lactamase family protein	0.0036	0.0023	0.0102
Brugia malayi	hypothetical protein	0.0027	0.0008	0.0029
Trypanosoma cruzi	hypothetical protein, conserved	0.0027	0.0008	0.0142
Leishmania major	GDP-mannose pyrophosphorylase	0.0029	0.001	0.0186
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0023	0.0501
Echinococcus multilocularis	mothers against decapentaplegic 6	0.0036	0.0024	0.0028
Echinococcus multilocularis	lamin	0.0107	0.0148	0.0175
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0325	0.0535	1
Schistosoma mansoni	hypothetical protein	0.0218	0.0346	0.0408
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0023	0.0027
Echinococcus multilocularis	smad	0.0081	0.0103	0.0122
Loa Loa (eye worm)	MH1 domain-containing protein	0.0036	0.0024	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0553	0.0939	0.454
Echinococcus multilocularis	microtubule associated protein 2	0.4823	0.8495	1
Schistosoma mansoni	glucosamine-1-phosphate N-acetyltransferase	0.0029	0.001	0.0012
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0023	0.0427
Schistosoma mansoni	smad1 5 8 and	0.0081	0.0103	0.0122
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0047	0.0042	0.0783
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0002	0.0049
Brugia malayi	TAR-binding protein	0.0061	0.0068	0.0321
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0023	0.0102
Entamoeba histolytica	hypothetical protein	0.0218	0.0346	1
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0057	0.006	0.0071
Schistosoma mansoni	phosphatidylinositol-4-phosphate 5-kinase type II	0.0157	0.0238	0.028
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0553	0.0939	0.454
Echinococcus multilocularis	mothers against decapentaplegic 2	0.0036	0.0024	0.0028
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.001	0.0012
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0057	0.006	0.0281
Brugia malayi	MH1 domain containing protein	0.0081	0.0103	0.049
Onchocerca volvulus		0.0107	0.0148	0.6198
Leishmania major	serine acetyltransferase	0.0027	0.0008	0.0142
Mycobacterium ulcerans	hypothetical protein	0.0956	0.1652	0.1651
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.032	0.0526	0.2539
Echinococcus granulosus	sentrin specific protease 7	0.0149	0.0224	0.0264
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0175	0.027	0.0317
Loa Loa (eye worm)	TAR-binding protein	0.0061	0.0068	0.0321
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0068	0.0081
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0057	0.006	0.1111
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0105	0.0145	0.0143
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0057	0.006	0.0071
Toxoplasma gondii	eukaryotic initiation factor-2B, gamma subunit, putative	0.0956	0.1652	1
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.001	0.0012
Echinococcus multilocularis	tar DNA binding protein	0.0061	0.0068	0.0081
Brugia malayi	beta-lactamase family protein	0.0036	0.0023	0.0102
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0069	0.1164
Leishmania major	hypothetical protein, conserved	0.0027	0.0008	0.0142
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0105	0.0145	0.0143
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0023	0.0021
Mycobacterium ulcerans	hypothetical protein	0.0956	0.1652	0.1651
Plasmodium vivax	ataxin-2 like protein, putative	0.0051	0.0049	1
Echinococcus granulosus	tumor protein p63	0.0693	0.1187	0.1397
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0069	0.1164
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0068	0.0081
Onchocerca volvulus		0.0157	0.0238	1
Trichomonas vaginalis	mannose-1-phosphate guanyltransferase, putative	0.0027	0.0008	0.0166
Echinococcus multilocularis	mannose 1 phosphate guanyltransferase beta	0.0027	0.0008	0.001
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.001	0.0036
Trypanosoma cruzi	GDP-mannose pyrophosphorylase	0.0029	0.001	0.0186
Trichomonas vaginalis	glucose-1-phosphate thymidylyltransferase, putative	0.0029	0.001	0.0218
Brugia malayi	hypothetical protein	0.0027	0.0008	0.0029
Brugia malayi	hypothetical protein	0.0033	0.0018	0.0075
Schistosoma mansoni	cellular tumor antigen P53	0.0101	0.0139	0.0164
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.032	0.0526	0.0619
Leishmania major	cathepsin L-like protease	0.0062	0.0069	0.1289
Schistosoma mansoni	DNA polymerase epsilon catalytic subunit	0.0027	0.0008	0.001
Mycobacterium ulcerans	glutaminase	0.028	0.0456	0.0454
Toxoplasma gondii	thioredoxin reductase	0.0046	0.0041	0.02
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.032	0.0526	0.2539
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0047	0.0042	0.005
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0069	0.1289
Echinococcus granulosus	mannose 1 phosphate guanyltransferase beta	0.0029	0.001	0.0012
Schistosoma mansoni	survival motor neuron protein	0.0099	0.0136	0.016
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0171	0.0263	0.0261
Echinococcus granulosus	intermediate filament protein	0.0107	0.0148	0.0175
Brugia malayi	glutaminase DH11.1	0.028	0.0456	0.2198
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0057	0.006	0.0071
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0023	0.0027
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0081	0.0103	0.0122
Loa Loa (eye worm)	RNA binding protein	0.0061	0.0068	0.0321
Mycobacterium tuberculosis	Probable dehydrogenase	0.0105	0.0145	0.0143
Brugia malayi	hypothetical protein	0.0027	0.0008	0.0029
Echinococcus granulosus	transcription factor eb	0.0106	0.0148	0.0174
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0002	0.0049
Brugia malayi	MH1 domain containing protein	0.0081	0.0103	0.049
Leishmania major	cathepsin L-like protease	0.0062	0.0069	0.1289
Trypanosoma cruzi	hypothetical protein, conserved	0.0027	0.0008	0.0142
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0229	0.0366	0.0363
Brugia malayi	MH1 domain containing protein	0.0045	0.0039	0.0179
Schistosoma mansoni	hypothetical protein	0.0175	0.027	0.0317
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0023	0.0027
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.0041	0.0188
Echinococcus multilocularis	Smad4	0.0081	0.0103	0.0122
Brugia malayi	hypothetical protein	0.0027	0.0008	0.0029
Onchocerca volvulus		0.0036	0.0023	0.0895
Trichomonas vaginalis	esterase, putative	0.0036	0.0023	0.0501
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0154	0.0232	0.425
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.0041	0.0048
Echinococcus granulosus	snurportin 1	0.0303	0.0496	0.0583
Brugia malayi	beta-lactamase	0.0036	0.0023	0.0102
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0002	0.0032
Schistosoma mansoni	Smad4	0.0036	0.0024	0.0028
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0956	0.1652	0.1651
Loa Loa (eye worm)	hypothetical protein	0.0057	0.006	0.0281
Brugia malayi	MH2 domain containing protein	0.119	0.2065	1
Onchocerca volvulus		0.0101	0.0139	0.5815
Echinococcus granulosus	Smad4	0.0081	0.0103	0.0122
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0046	0.0041	0.0752
Schistosoma mansoni	hypothetical protein	0.0175	0.027	0.0317
Plasmodium falciparum	ataxin-2 like protein, putative	0.0051	0.0049	1
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0081	0.0103	0.0122
Echinococcus multilocularis	sentrin specific protease 7	0.0149	0.0224	0.0264
Brugia malayi	hypothetical protein	0.0218	0.0346	0.1669
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0061	0.0068	0.0321
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0068	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0175	0.027	0.1296
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0154	0.0232	0.4332
Echinococcus multilocularis	geminin	0.0687	0.1175	0.1383
Schistosoma mansoni	Smad4	0.0081	0.0103	0.0122
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0047	0.0042	0.0783
Echinococcus multilocularis	isocitrate dehydrogenase	0.0047	0.0042	0.005
Echinococcus multilocularis	mannose 1 phosphate guanyltransferase beta	0.0029	0.001	0.0012
Entamoeba histolytica	acetyltransferase, putative	0.0027	0.0008	0.0219
Trypanosoma brucei	nucleotidyl transferase, putative	0.0029	0.001	0.0045
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0099	0.0136	0.0646
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0023	0.0501
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0051	0.0051	0.006
Schistosoma mansoni	intermediate filament proteins	0.0107	0.0148	0.0175
Echinococcus granulosus	expressed conserved protein	0.0136	0.0201	0.0236
Brugia malayi	latrophilin 2 splice variant baaae	0.0378	0.0629	0.3039
Brugia malayi	MH2 domain containing protein	0.0081	0.0103	0.049
Entamoeba histolytica	acetyltransferase, putative	0.0027	0.0008	0.0219
Mycobacterium tuberculosis	Probable serine acetyltransferase CysE (sat)	0.0027	0.0008	0.0006
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0218	0.0346	0.0408
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0105	0.0145	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0378	0.0629	0.3039
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0008	0.0029
Trichomonas vaginalis	glutaminase, putative	0.028	0.0456	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0046	0.0041	0.0758
Schistosoma mansoni	smad1 5 8 and	0.0081	0.0103	0.0122
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.032	0.0526	0.0619
Echinococcus granulosus	polycomb protein SCMH1	0.005	0.0048	0.0057
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0002	0.0049
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0107	0.0148	0.0709
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0046	0.0041	0.0039
Plasmodium falciparum	glutathione reductase	0.0046	0.0041	0.7974
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0956	0.1652	0.1651
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0056	0.0058	0.1083
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.032	0.0526	0.0619
Echinococcus multilocularis	expressed conserved protein	0.0136	0.0201	0.0236
Loa Loa (eye worm)	MH2 domain-containing protein	0.0036	0.0024	0.0105
Leishmania major	hypothetical protein, conserved	0.0027	0.0008	0.0142
Schistosoma mansoni	phosphatidylinositol-4-phosphate 5-kinase type II	0.0157	0.0238	0.028
Brugia malayi	eIF4-gamma/eIF5/eIF2-epsilon family protein	0.0027	0.0008	0.0029
Wolbachia endosymbiont of Brugia malayi	N-acetylglucosamine-1-phosphate uridyltransferase	0.5673	1	1
Leishmania major	hypothetical protein, conserved	0.0051	0.0049	0.0915
Loa Loa (eye worm)	GDP-mannose pyrophosphorylase B	0.0027	0.0008	0.0029
Schistosoma mansoni	lamin	0.0107	0.0148	0.0175
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0023	0.0102
Echinococcus granulosus	importin subunit beta 1	0.0028	0.001	0.0012
Schistosoma mansoni	importin beta-1	0.0028	0.001	0.0012
Brugia malayi	hypothetical protein	0.0155	0.0234	0.1122
Brugia malayi	zgc:92842	0.0027	0.0008	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0139	0.0665
Echinococcus granulosus	SAM and MBT domain containing protein	0.005	0.0048	0.0057
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0069	0.1164
Brugia malayi	intermediate filament protein	0.0107	0.0148	0.0709
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0069	0.1289
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0027	0.0008	0.0006
Chlamydia trachomatis	acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase	0.0027	0.0008	0.5
Loa Loa (eye worm)	glutathione reductase	0.0046	0.0041	0.0188
Echinococcus granulosus	lamin dm0	0.0107	0.0148	0.0175
Echinococcus multilocularis	transcription factor eb	0.0106	0.0148	0.0174
Entamoeba histolytica	acetyltransferase, putative	0.0027	0.0008	0.0219
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0023	0.0102
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0023	0.0021
Mycobacterium leprae	PROBABLE SERINE ACETYLTRANSFERASE CYSE (SAT)	0.0027	0.0008	0.0006
Entamoeba histolytica	serine acetyltransferase, putative	0.0027	0.0008	0.0219
Echinococcus multilocularis	phosphatidylinositol 5 phosphate 4 kinase type 2	0.0157	0.0238	0.028
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0046	0.0041	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0145	0.0692
Loa Loa (eye worm)	MH2 domain-containing protein	0.0081	0.0103	0.049
Mycobacterium tuberculosis	Probable oxidoreductase	0.0116	0.0166	0.0164
Trypanosoma cruzi	major cysteine proteinase, putative	0.0049	0.0046	0.085
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0023	0.0021
Brugia malayi	Isocitrate dehydrogenase	0.0047	0.0042	0.0195
Entamoeba histolytica	acetyltransferase, putative	0.0027	0.0008	0.0219
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0175	0.027	0.0317
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0047	0.0042	0.065
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0047	0.0042	0.005
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0175	0.027	0.0317
Mycobacterium leprae	POSSIBLE TRANSFERASE	0.0027	0.0008	0.0006
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0069	0.1164
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0002	0.0032
Brugia malayi	mothers against decapentaplegic homolog 3	0.0036	0.0024	0.0105
Leishmania major	mitochondrial DNA polymerase beta	0.0325	0.0535	1
Echinococcus granulosus	mothers against decapentaplegic 5	0.0081	0.0103	0.0122
Echinococcus multilocularis	dynactin 5 p25	0.0027	0.0008	0.001
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0023	0.0021
Entamoeba histolytica	bacterial transferase hexapeptide family protein	0.0027	0.0008	0.0219
Leishmania major	hypothetical protein, conserved	0.0027	0.0008	0.0142
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.001	0.0036
Plasmodium falciparum	importin beta, putative	0.0028	0.001	0.0463
Plasmodium vivax	glutathione reductase, putative	0.0046	0.0041	0.7974
Loa Loa (eye worm)	MH2 domain-containing protein	0.119	0.2065	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0107	0.0148	0.0709
Brugia malayi	Smad1	0.0081	0.0103	0.049
Plasmodium vivax	mannose-1-phosphate guanyltransferase, putative	0.0029	0.001	0.0572
Loa Loa (eye worm)	MBCTL1	0.0057	0.006	0.0281
Echinococcus granulosus	survival motor neuron protein 1	0.0487	0.0821	0.0967
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0068	0.0081
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0023	0.0501
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0023	0.0021
Brugia malayi	Nucleotidyl transferase family protein	0.0029	0.001	0.004
Schistosoma mansoni	glutaminase	0.028	0.0456	0.0536
Schistosoma mansoni	smad1 5 8 and	0.0081	0.0103	0.0122
Trypanosoma cruzi	hypothetical protein	0.0027	0.0008	0.0142
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0303	0.0496	0.2392
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0047	0.0042	0.005
Toxoplasma gondii	hypothetical protein	0.0052	0.0053	0.0271
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0069	0.1164
Brugia malayi	isocitrate dehydrogenase	0.0047	0.0042	0.0195
Loa Loa (eye worm)	GDP-mannose pyrophosphorylase B	0.0029	0.001	0.004
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0147	0.0701
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0051	0.0236
Plasmodium falciparum	thioredoxin reductase	0.0046	0.0041	0.7974
Plasmodium vivax	importin-beta 2, putative	0.0028	0.001	0.0463
Brugia malayi	Thioredoxin reductase	0.0046	0.0041	0.0188
Mycobacterium ulcerans	serine acetyltransferase CysE	0.0027	0.0008	0.0006
Echinococcus granulosus	dynactin 5 p25	0.0027	0.0008	0.001
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0069	0.1164
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0049	0.0229
Echinococcus granulosus	mannose 1 phosphate guanyltransferase beta	0.0027	0.0008	0.001
Trypanosoma brucei	trypanothione reductase	0.0046	0.0041	0.0625
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0069	0.1164
Loa Loa (eye worm)	mbt repeat family protein	0.005	0.0048	0.0222
Mycobacterium ulcerans	hypothetical protein	0.0171	0.0263	0.0261
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0047	0.0042	0.005
Toxoplasma gondii	isocitrate dehydrogenase	0.0047	0.0042	0.0208
Echinococcus multilocularis	lamin dm0	0.0107	0.0148	0.0175
Echinococcus multilocularis	GPCR, family 2	0.0175	0.027	0.0317
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0057	0.0061	0.0284
Mycobacterium ulcerans	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase	0.5673	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0027	0.0008	0.0142
Onchocerca volvulus	Mothers against decapentaplegic homolog	0.0036	0.0024	0.0921
Schistosoma mansoni	smad	0.0036	0.0024	0.0028
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0023	0.0501
Entamoeba histolytica	acetyltransferase, putative	0.0027	0.0008	0.0219
Echinococcus granulosus	histone acetyltransferase MYST2	0.0057	0.006	0.0071
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0069	0.1164
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0023	0.0102
Toxoplasma gondii	isocitrate dehydrogenase	0.0047	0.0042	0.0208
Echinococcus granulosus	tar DNA binding protein	0.0061	0.0068	0.0081
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0175	0.027	0.1296
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0175	0.027	0.0317
Loa Loa (eye worm)	nuclear factor I	0.0045	0.0039	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0023	0.0102
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0105	0.0145	0.0143
Echinococcus granulosus	smad	0.0081	0.0103	0.0122
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0069	0.1164
Echinococcus granulosus	lamin	0.0107	0.0148	0.0175
Echinococcus granulosus	mannose 1 phosphate guanyltransferase	0.0029	0.001	0.0012
Mycobacterium ulcerans	hypothetical protein	0.0027	0.0008	0.0006
Treponema pallidum	licC protein (licC)	0.0956	0.1652	0.5
Schistosoma mansoni	hypothetical protein	0.0378	0.0629	0.0741
Schistosoma mansoni	Smad4	0.0036	0.0024	0.0028
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0047	0.0042	0.0195
Toxoplasma gondii	LsmAD domain-containing protein	0.0051	0.0049	0.0251
Trypanosoma brucei	PAB1-binding protein , putative	0.0051	0.0049	0.0784
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0057	0.006	0.0071
Trichomonas vaginalis	maltose O-acetyltransferase, putative	0.0027	0.0008	0.0166
Schistosoma mansoni	mannose-1-phosphate guanyltransferase	0.0029	0.001	0.0012
Brugia malayi	GDP-mannose pyrophosphorylase B	0.0029	0.001	0.004
Trichomonas vaginalis	sugar-1-phosphate guanyl transferase, putative	0.0029	0.001	0.0218
Onchocerca volvulus		0.005	0.0048	0.1941
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0553	0.0939	0.454
Entamoeba histolytica	hypothetical protein	0.0218	0.0346	1
Onchocerca volvulus		0.0099	0.0136	0.565
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0023	0.0021
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0023	0.0021
Echinococcus granulosus	geminin	0.0687	0.1175	0.1383
Echinococcus multilocularis	polycomb protein SCMH1	0.005	0.0048	0.0057
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0325	0.0535	1
Schistosoma mansoni	sex comb on midleg homolog	0.005	0.0048	0.0057
Onchocerca volvulus		0.0155	0.0234	0.9811
Entamoeba histolytica	translation initiation factor eIF-2B epsilon subunit, putative	0.0029	0.001	0.0287
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0046	0.0041	0.0619
Mycobacterium ulcerans	d-alpha-D-mannose-1-phosphate guanylyltransferase ManB	0.0029	0.001	0.0008
Schistosoma mansoni	hypothetical protein	0.0687	0.1175	0.1383
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0023	0.0021
Trypanosoma cruzi	serine acetyltransferase, putative	0.0027	0.0008	0.0142
Schistosoma mansoni	dynactin subunit P25	0.0027	0.0008	0.001
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0023	0.0289
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.032	0.0526	0.0619
Toxoplasma gondii	ABC1 family protein	0.0036	0.0023	0.0093
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0023	0.0021
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0154	0.0232	0.4332
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.4105	0.7225	0.8504
Entamoeba histolytica	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0149	0.0224	0.6458
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0325	0.0535	1
Brugia malayi	MH1 domain containing protein	0.0045	0.0039	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0024	0.0105
Echinococcus multilocularis	snurportin 1	0.0303	0.0496	0.0583
Loa Loa (eye worm)	glutaminase	0.028	0.0456	0.2198
Echinococcus multilocularis	mannose 1 phosphate guanyltransferase	0.0029	0.001	0.0012
Mycobacterium ulcerans	molybdopterin-guanine dinucleotide biosynthesis protein A	0.0956	0.1652	0.1651
Loa Loa (eye worm)	hypothetical protein	0.005	0.0048	0.0222
Loa Loa (eye worm)	glutaminase 2	0.028	0.0456	0.2198
Loa Loa (eye worm)	MH1 domain-containing protein	0.0081	0.0103	0.049
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0023	0.0102
Onchocerca volvulus		0.0036	0.0023	0.0895
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.0041	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0023	0.0102
Trypanosoma cruzi	hypothetical protein, conserved	0.0027	0.0008	0.0142
Mycobacterium tuberculosis	Possible transferase	0.0027	0.0008	0.0006
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0047	0.0042	0.004
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0023	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0487	0.0821	0.3971
Trypanosoma cruzi	Translation initiation factor eIF-2B subunit epsilon, putative	0.0029	0.001	0.0186
Onchocerca volvulus		0.0036	0.0023	0.0895
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0047	0.0042	0.8289
Brugia malayi	cytoplasmic intermediate filament protein	0.0057	0.0061	0.0284
Chlamydia trachomatis	UDP-3-O-acylglucosamine N-acyltransferase	0.0027	0.0008	0.5
Loa Loa (eye worm)	transcription factor SMAD2	0.119	0.2065	1
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0051	0.0051	0.006
Schistosoma mansoni	microtubule-associated protein tau	0.4823	0.8495	1
Plasmodium falciparum	mannose-1-phosphate guanyltransferase, putative	0.0029	0.001	0.0572
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.0068	0.0081
Brugia malayi	glutathione reductase	0.0046	0.0041	0.0188

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1179655

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1157425