TDR Targets

Basic information

Technical information

TDR Targets ID: 1212197
Name: 1-(4-hydroxy-1,1-dioxothiolan-3-yl)-3-phenylu rea
MW: 270.305 | Formula: C11H14N2O4S
H donors: 3 H acceptors: 4 LogP: -0.48 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccccc1)NC1CS(=O)(=O)CC1O
InChi: 1S/C11H14N2O4S/c14-10-7-18(16,17)6-9(10)13-11(15)12-8-4-2-1-3-5-8/h1-5,9-10,14H,6-7H2,(H2,12,13,15)
InChiKey: OJCUILNGXCCKAX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(4-hydroxy-1,1-dioxo-thiolan-3-yl)-3-phenyl-urea
1-(4-hydroxy-1,1-dioxo-3-thiolanyl)-3-phenylurea
1-(4-hydroxy-1,1-diketo-thiolan-3-yl)-3-phenyl-urea
MLS000058796
N-(4-hydroxy-1,1-dioxidotetrahydro-3-thienyl)-N'-phenylurea
SMR000069062
Oprea1_590342
1-(4-Hydroxy-1,1-dioxo-tetrahydro-1lambda*6*-thiophen-3-yl)-3-phenyl-urea
BAS 05437783
STOCK1S-38200

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	aldehyde dehydrogenase 1 family, member A1	Starlite/ChEMBL	No references
Homo sapiens	glucosidase, alpha	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus multilocularis	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	Retinal dehydrogenase 1, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Aldehyde dehydrogenase X, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Brugia malayi	Glycosyl hydrolases family 31 protein	Get druggable targets OG5_127055	All targets in OG5_127055
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Aldehyde dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus granulosus	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase	Get druggable targets OG5_127055	All targets in OG5_127055
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	alpha-glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	Lysosomal alpha-glucosidase precursor, putative	Get druggable targets OG5_127055	All targets in OG5_127055
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	ko:K01187 alpha-glucosidase [EC3.2.1.20], putative	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania mexicana	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania donovani	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus multilocularis	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Leishmania braziliensis	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative	Get druggable targets OG5_126638	All targets in OG5_126638
Onchocerca volvulus		Get druggable targets OG5_127055	All targets in OG5_127055
Leishmania infantum	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Neospora caninum	hypothetical protein	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	alpha-glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Toxoplasma gondii	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose	Get druggable targets OG5_127055	All targets in OG5_127055

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium tuberculosis	Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1	aldehyde dehydrogenase 1 family, member A1	501 aa	456 aa	33.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0016	0.0019	0.0041
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0016	0.0019	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0512	0.0512
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0025	0.0204
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0069	0.0156	0.0729
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0042	0.4421
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.014	0.0342	0.1019
Brugia malayi	Integrin alpha cytoplasmic region family protein	0.0114	0.0273	0.0273
Echinococcus multilocularis	baculoviral IAP repeat containing protein	0.0106	0.0253	0.1184
Schistosoma mansoni	neprilysin-2 (M13 family)	0.014	0.0342	0.1019
Onchocerca volvulus		0.003	0.0054	0.0254
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0268	0.0678	0.0678
Toxoplasma gondii	aldehyde dehydrogenase	0.0073	0.0168	0.2289
Schistosoma mansoni	hypothetical protein	0.0345	0.0878	0.2643
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0025	0.0089
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0138	0.04
Loa Loa (eye worm)	hypothetical protein	0.021	0.0525	0.0524
Loa Loa (eye worm)	hypothetical protein	0.021	0.0525	0.0524
Echinococcus granulosus	intermediate filament protein	0.0028	0.0049	0.0176
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0015	0.0015
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.0124	0.0299	0.0299
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0304	0.0771	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0121	0.0293	0.0293
Echinococcus granulosus	geminin	0.0345	0.0878	0.3146
Entamoeba histolytica	acetyltransferase, GNAT family	0.0041	0.0082	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0041	0.004
Loa Loa (eye worm)	zinc metallopeptidase 4	0.0068	0.0153	0.0153
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0065	0.0145	0.068
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0016	0.0019	0.0119
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0044	0.0092	0.1083
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0041	0.0407
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0044	0.0092	0.0329
Loa Loa (eye worm)	acetyltransferase	0.0151	0.037	0.037
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0025	0.0204
Echinococcus granulosus	GPCR family 2	0.0016	0.0019	0.0067
Brugia malayi	Phospholipase A2 family protein	0.0683	0.1762	0.1762
Schistosoma mansoni	intracisternal A-particle retropepsin (A02 family)	0.1273	0.3307	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0019	0.0019
Loa Loa (eye worm)	integrin alpha pat-2	0.0231	0.0582	0.0581
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0112	0.0111
Echinococcus granulosus	tar DNA binding protein	0.0062	0.0138	0.0492
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0195	0.0487	0.2284
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0195	0.0487	0.1458
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0042	0.2203
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0041	0.0041
Schistosoma mansoni	cpg binding protein	0.003	0.0054	0.0147
Brugia malayi	hypothetical protein	0.0013	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0024	0.0024
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0006	0.0025
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0197	0.0491	0.0491
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0044	0.0092	0.1083
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0014	0.0012	0.0053
Brugia malayi	Integrin alpha pat-2 precursor	0.015	0.0369	0.0369
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0013	0.001	0.0033
Brugia malayi	TATA binding protein associated factor	0.0013	0.001	0.001
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0018	0.0024	0.0212
Trichomonas vaginalis	glucosylceramidase, putative	0.0268	0.0678	0.8782
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0024	0.0024
Mycobacterium tuberculosis	Probable zinc metalloprotease Zmp1	0.0277	0.0701	1
Echinococcus multilocularis	neuropeptide s receptor	0.048	0.1233	0.5786
Leishmania major	alpha glucosidase II subunit, putative	0.0044	0.009	0.5099
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0197	0.0491	0.2303
Schistosoma mansoni	inhibitor of apoptosis protein	0.0106	0.0253	0.0748
Mycobacterium ulcerans	epoxide hydrolase EphA	0.0167	0.0412	0.5815
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.0124	0.0299	0.1404
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0072	0.0165	0.0484
Schistosoma mansoni	alpha-glucosidase	0.0169	0.0419	0.1253
Loa Loa (eye worm)	hypothetical protein	0.0013	0.001	0.001
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0041	0.0448
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0042	0.2203
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0512	0.0512
Mycobacterium leprae	probable zinc metalloprotease	0.0277	0.0701	1
Schistosoma mansoni	hypothetical protein	0.0016	0.0019	0.0041
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0044	0.0092	0.1191
Echinococcus granulosus	Solute carrier family 22 5	0.1076	0.279	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.0041	0.0448
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0016	0.0019	0.0119
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0013	0.001	0.0044
Entamoeba histolytica	acyl-coA synthetase, putative	0.0025	0.0041	0.0407
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.009	0.1061
Trichomonas vaginalis	glucosylceramidase, putative	0.0268	0.0678	0.8782
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0277	0.0701	0.2108
Loa Loa (eye worm)	hypothetical protein	0.0013	0.001	0.0009
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.0041	0.0448
Onchocerca volvulus		0.0028	0.0049	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0042	0.0041
Mycobacterium tuberculosis	Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase)	0.0167	0.0412	0.574
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0006	0.0019
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0044	0.009	0.1061
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0044	0.009	0.1167
Schistosoma mansoni	ap endonuclease	0.0019	0.0025	0.0059
Trichomonas vaginalis	alpha-glucosidase, putative	0.0016	0.0019	0.0119
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.009	0.1061
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0151	0.037	0.1736
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0025	0.1881
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0193	0.0193
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0041	0.1956
Loa Loa (eye worm)	hypothetical protein	0.0277	0.0701	0.0701
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0044	0.0092	0.1191
Schistosoma mansoni	hypothetical protein	0.0016	0.0019	0.0041
Trichomonas vaginalis	glucosylceramidase, putative	0.0176	0.0437	0.5611
Echinococcus granulosus	neuropeptide receptor A26	0.048	0.1233	0.4418
Trichomonas vaginalis	glucosylceramidase, putative	0.0268	0.0678	0.8782
Onchocerca volvulus		0.0028	0.0049	0.0227
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0049	0.0049
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0138	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0068	0.0068
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0025	0.1062
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0041	0.0041
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0138	0.0138
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.014	0.0342	0.1019
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.0041	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0253	0.0252
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0044	0.009	0.1061
Leishmania major	glycosyl hydrolase-like protein	0.0016	0.0019	0.0573
Loa Loa (eye worm)	TK/EPH protein kinase	0.0082	0.0191	0.0191
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0013	0.001	0.0044
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0044	0.009	0.1061
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0069	0.0068
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0013	0.001	0.0033
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0073	0.0168	0.2152
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0112	0.0111
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0025	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0041	0.004
Echinococcus granulosus	leukotriene A 4 hydrolase	0.0124	0.0299	0.1072
Brugia malayi	ephrin receptor 1 precursor	0.0031	0.0057	0.0057
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0049	0.0049
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0304	0.0771	1
Schistosoma mansoni	inhibitor of apoptosis (iap) domain family member	0.0106	0.0253	0.0748
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.014	0.0342	0.1019
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0013	0.001	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0019	0.0019
Trichomonas vaginalis	glucosylceramidase, putative	0.0268	0.0678	0.8782
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.009	0.1061
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0069	0.0156	1
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0044	0.009	0.1061
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.3831	1	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0268	0.0678	0.8782
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0013	0.001	0.0044
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0013	0.001	0.0033
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0138	0.04
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.0106	0.0253	0.0253
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0138	0.0137
Echinococcus granulosus	inhibitor of apoptosis protein	0.0106	0.0253	0.0904
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0195	0.0487	0.2284
Echinococcus multilocularis	inhibitor of apoptosis protein	0.0106	0.0253	0.1184
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0013	0.001	0.0033
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.0012	0.004
Brugia malayi	Peptidase family M1 containing protein	0.0013	0.001	0.001
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0304	0.0771	1
Onchocerca volvulus		0.0137	0.0335	0.1859
Brugia malayi	Peptidase family M13 containing protein	0.0277	0.0701	0.0701
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0024	0.0024
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.0138	0.0644
Onchocerca volvulus		0.0064	0.0143	0.0763
Brugia malayi	hypothetical protein	0.0111	0.0266	0.0266
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.0041	0.0448
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0063	0.0142	0.0412
Schistosoma mansoni	ap endonuclease	0.0019	0.0025	0.0059
Echinococcus multilocularis	transcription factor Dp 1	0.004	0.008	0.0374
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0273	0.0691	0.0691
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.009	0.1061
Trichomonas vaginalis	glucosylceramidase, putative	0.0185	0.0461	0.5937
Echinococcus granulosus	aminopeptidase N	0.0013	0.001	0.0033
Brugia malayi	peptidase family M13 containing protein	0.0068	0.0153	0.0153
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0013	0.001	0.0012
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0112	0.0112
Echinococcus granulosus	integrin alpha ps	0.0067	0.0152	0.0545
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0148	0.0364	0.4898
Treponema pallidum	fructose-bisphosphate aldolase	0.0304	0.0771	1
Echinococcus multilocularis	neuropeptide receptor A26	0.048	0.1233	0.5786
Trichomonas vaginalis	glucosylceramidase, putative	0.0176	0.0437	0.5611
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0151	0.037	0.1104
Brugia malayi	acetyltransferase, GNAT family protein	0.0151	0.037	0.037
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.0041	0.0278
Schistosoma mansoni	neprilysin	0.0072	0.0165	0.0484
Schistosoma mansoni	cpg binding protein	0.0032	0.0059	0.0161
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0024	0.5
Schistosoma mansoni	integrin alpha-ps	0.0035	0.0068	0.0189
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0044	0.009	0.009
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0138	0.04
Echinococcus multilocularis	integrin alpha ps	0.0032	0.0061	0.0283
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0044	0.009	0.0423
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0512	0.0512
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0304	0.0771	1
Schistosoma mansoni	endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase)	0.0068	0.0153	0.0446
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0019	0.0019
Onchocerca volvulus	Phospholipase A2 homolog	0.0273	0.0691	0.389
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0195	0.0487	0.1458
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0073	0.0168	0.0601
Schistosoma mansoni	hypothetical protein	0.0032	0.0061	0.0167
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0195	0.0487	0.1458
Schistosoma mansoni	ephrin receptor	0.0065	0.0145	0.0423
Brugia malayi	MH2 domain containing protein	0.0121	0.0293	0.0293
Echinococcus granulosus	transcription factor Dp 1	0.004	0.008	0.0286
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0069	0.0069
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0069	0.0156	0.9218
Schistosoma mansoni	integrin alpha-ps	0.0067	0.0152	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0019	0.0018
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0138	0.04
Schistosoma mansoni	Nep2 peptidase (M13 family)	0.014	0.0342	0.1019
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0069	0.0156	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0061	0.0061
Schistosoma mansoni	lamin	0.0028	0.0049	0.0133
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0025	0.0025
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0112	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0013	0.001	0.0009
Echinococcus multilocularis	cpg binding protein	0.0032	0.0059	0.0274
Trichomonas vaginalis	alpha-glucosidase, putative	0.0016	0.0019	0.0119
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0068	0.0153	0.0446
Trichomonas vaginalis	glucosylceramidase, putative	0.0176	0.0437	0.5611
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0253	0.0252
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0025	0.213
Echinococcus multilocularis	lamin dm0	0.0028	0.0049	0.0231
Loa Loa (eye worm)	transcription factor SMAD2	0.0121	0.0293	0.0293
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0025	0.0025
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0019	0.0088
Loa Loa (eye worm)	POT family protein	0.004	0.0081	0.0081
Plasmodium falciparum	histone acetyltransferase GCN5	0.0041	0.0082	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0042	0.2203
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0041	0.1956
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0143	0.0143
Brugia malayi	TAR-binding protein	0.0062	0.0138	0.0138
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0069	0.0156	1
Echinococcus multilocularis	integrin alpha ps	0.0067	0.0152	0.0713
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0061	0.006
Trichomonas vaginalis	glucosylceramidase, putative	0.0176	0.0437	0.5611
Schistosoma mansoni	hypothetical protein	0.0072	0.0165	0.0484
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0042	0.4421
Loa Loa (eye worm)	hypothetical protein	0.021	0.0525	0.0524
Onchocerca volvulus		0.0114	0.0274	0.1507
Brugia malayi	CXXC zinc finger family protein	0.003	0.0054	0.0054
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0025	0.0051
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0019	0.0067
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0138	0.04
Loa Loa (eye worm)	TATA binding protein associated factor	0.0013	0.001	0.0009
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0013	0.001	0.0009
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0025	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0273	0.0273
Brugia malayi	POT family protein	0.004	0.0081	0.0081
Onchocerca volvulus		0.0025	0.0041	0.0177
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0041	0.0407
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0042	0.0465
Trichomonas vaginalis	glucosylceramidase, putative	0.0176	0.0437	0.5611
Trichomonas vaginalis	glucosylceramidase, putative	0.0176	0.0437	0.5611
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0268	0.0678	0.0678
Trichomonas vaginalis	glucosylceramidase, putative	0.0176	0.0437	0.5611
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0304	0.0771	1
Schistosoma mansoni	hypothetical protein	0.0106	0.0253	0.0748
Leishmania major	hypothetical protein, conserved	0.0025	0.0042	0.2031
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0044	0.009	0.1061
Echinococcus multilocularis	integrin alpha 3	0.0115	0.0277	0.13
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.0277	0.0701	0.0701
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0146	0.0359	0.1286
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0195	0.0487	0.0487
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0195	0.0487	0.1744
Trichomonas vaginalis	alpha-glucosidase, putative	0.0016	0.0019	0.0119
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0195	0.0487	0.0487
Echinococcus multilocularis	geminin	0.0345	0.0878	0.412
Loa Loa (eye worm)	hypothetical protein	0.021	0.0525	0.0524
Schistosoma mansoni	hypothetical protein	0.0016	0.0019	0.0041
Echinococcus multilocularis	endothelin converting enzyme 1	0.0277	0.0701	0.3291
Loa Loa (eye worm)	hypothetical protein	0.0013	0.001	0.0009
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0049	0.0049
Onchocerca volvulus		0.0106	0.0253	0.1386
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0049	0.0133
Brugia malayi	Peptidase family M1 containing protein	0.0013	0.001	0.001
Schistosoma mansoni	hypothetical protein	0.0072	0.0165	0.0484
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0041	0.0448
Schistosoma mansoni	endothelin-converting enzyme-related	0.0068	0.0153	0.0446
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0068	0.0153	0.0446
Echinococcus granulosus	endothelin converting enzyme 1	0.0277	0.0701	0.2513
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0016	0.0019	0.0621
Toxoplasma gondii	exonuclease III APE	0.0019	0.0025	0.0224
Brugia malayi	RNA binding protein	0.0062	0.0138	0.0138
Schistosoma mansoni	integrin alpha	0.015	0.0369	0.1101
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0024	0.0024
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0069	0.0156	0.1918
Onchocerca volvulus	Deterin homolog	0.0106	0.0253	0.1386
Loa Loa (eye worm)	hypothetical protein	0.021	0.0525	0.0524
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0168	0.0492
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0148	0.0364	0.504
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0205	0.0512	0.0512
Echinococcus multilocularis	aminopeptidase N	0.0013	0.001	0.0044
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0068	0.0153	0.0446
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0016	0.0019	0.0119
Brugia malayi	hypothetical protein	0.0013	0.001	0.001
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0025	0.0979
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0013	0.001	0.0044
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.0041	0.0278
Schistosoma mansoni	hypothetical protein	0.0345	0.0878	0.2643
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0168	0.2289
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.009	0.5531
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0024	0.2019
Schistosoma mansoni	hypothetical protein	0.0035	0.0069	0.0191
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0138	0.0137
Echinococcus granulosus	integrin alpha 3	0.0115	0.0277	0.0993
Brugia malayi	Peptidase family M1 containing protein	0.0013	0.001	0.001
Echinococcus granulosus	lamin dm0	0.0028	0.0049	0.0176
Echinococcus multilocularis	lamin	0.0028	0.0049	0.0231
Echinococcus multilocularis	integrin alpha ps	0.0067	0.0152	0.0713
Brugia malayi	hypothetical protein	0.0016	0.0019	0.0019
Onchocerca volvulus	Glucosylceramidase homolog	0.0176	0.0437	0.2436
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0024	0.1782
Loa Loa (eye worm)	hypothetical protein	0.0683	0.1762	0.1762
Toxoplasma gondii	peptidase family M13 protein	0.0277	0.0701	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0012	0.0011
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0069	0.0156	1
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0069	0.0156	0.0557
Giardia lamblia	Histone acetyltransferase GCN5	0.0041	0.0082	0.0768
Loa Loa (eye worm)	hypothetical protein	0.0013	0.001	0.001
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0025	0.5
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0019	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0277	0.0701	0.0701
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0025	0.0224
Onchocerca volvulus	Uncharacterized family 31 glucosidase KIAA1161 homolog	0.0016	0.0019	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0048	0.0048
Trichomonas vaginalis	alpha-glucosidase, putative	0.0016	0.0019	0.0119
Schistosoma mansoni	hypothetical protein	0.0072	0.0165	0.0484
Echinococcus granulosus	ephrin type A receptor 4 A	0.0065	0.0145	0.052
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0019	0.0088
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0013	0.001	0.0033
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0025	0.1062
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.0124	0.0299	0.089
Loa Loa (eye worm)	hypothetical protein	0.0137	0.0335	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0041	0.004
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0304	0.0771	1
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0044	0.0092	1
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0197	0.0491	0.2303
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0068	0.0153	0.0446
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0073	0.0168	0.0787
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0304	0.0771	1
Trypanosoma brucei	glucosidase, putative	0.0044	0.009	0.5531
Trypanosoma brucei	glycosyl hydrolase-like protein	0.0016	0.0019	0.0621
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0205	0.0512	0.0512
Schistosoma mansoni	cpg binding protein	0.0032	0.0059	0.0161
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0013	0.001	0.0033
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0042	0.3903
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0304	0.0771	1
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0148	0.0364	0.5127
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0024	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0285	0.0284
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0019	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0205	0.0512	0.0512
Brugia malayi	hypothetical protein	0.0025	0.0042	0.0042
Schistosoma mansoni	hypothetical protein	0.0072	0.0165	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0277	0.0701	0.0701
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0041	0.1956
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0013	0.001	0.0044
Onchocerca volvulus	Phospholipase A2 homolog	0.0683	0.1762	1
Schistosoma mansoni	alpha glucosidase	0.0044	0.009	0.0257
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0019	0.0019
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0823	0.2131	1
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0044	0.009	0.1061
Schistosoma mansoni	aminopeptidase A (M01 family)	0.0013	0.001	0.0012
Echinococcus granulosus	neuropeptide s receptor	0.048	0.1233	0.4418
Echinococcus granulosus	baculoviral IAP repeat containing protein	0.0106	0.0253	0.0904
Trichomonas vaginalis	alpha-glucosidase, putative	0.0016	0.0019	0.0119
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0016	0.0019	0.0119
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.0106	0.0253	0.0253
Schistosoma mansoni	alpha-glucosidase	0.0169	0.0419	0.1253
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0168	0.0492
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.009	0.5531
Loa Loa (eye worm)	aminopeptidase N	0.0013	0.001	0.0009
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0069	0.0156	0.0156
Echinococcus multilocularis	musashi	0.0028	0.0049	0.0231
Toxoplasma gondii	histone lysine methyltransferase SET1	0.006	0.0134	0.1793
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0044	0.009	0.009
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0197	0.0491	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0024	0.0024
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0016	0.0019	0.0621
Brugia malayi	intermediate filament protein	0.0028	0.0049	0.0049
Echinococcus granulosus	neutral alpha glucosidase AB	0.0044	0.009	0.0323
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0168	0.2289
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0013	0.001	0.0044
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0168	0.2289
Mycobacterium ulcerans	zinc metalloprotease	0.0277	0.0701	1
Schistosoma mansoni	lamin	0.0028	0.0049	0.0133
Trichomonas vaginalis	glucosylceramidase, putative	0.0268	0.0678	0.8782
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0025	0.1062
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.021	0.0525	0.0524
Schistosoma mansoni	hypothetical protein	0.0072	0.0165	0.0484
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0049	0.0049
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.0231	0.0582	0.1745
Echinococcus granulosus	lysosomal alpha glucosidase	0.0197	0.0491	0.1758
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.0013	0.001	0.0012
Schistosoma mansoni	hypothetical protein	0.0072	0.0165	0.0484
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0073	0.0168	1
Echinococcus granulosus	lamin	0.0028	0.0049	0.0176
Echinococcus granulosus	integrin alpha ps	0.0032	0.0061	0.0216
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0304	0.0771	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0195	0.0487	0.1744
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0041	0.0448
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0041	0.0448
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0304	0.0771	1
Echinococcus granulosus	cpg binding protein	0.0032	0.0059	0.0209
Trichomonas vaginalis	alpha-glucosidase, putative	0.0044	0.009	0.1061
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0069	0.0156	0.0454
Giardia lamblia	Fructose-bisphosphate aldolase	0.0304	0.0771	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0185	0.0461	0.5937

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	> 71.485 uM	PUBCHEM_BIOASSAY: Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493008, AID493018, AID504382, AID504383]	ChEMBL.	No reference
Potency (functional)	= 0.8913 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ]	ChEMBL.	No reference
Potency (functional)	= 0.8913 um	PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ]	ChEMBL.	No reference
Potency (functional)	= 8.9125 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1323495

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1212197