Detailed information for compound 1213529

Basic information

Technical information
  • TDR Targets ID: 1213529
  • Name: 4-[4-(2,5-dimethylphenyl)sulfonylpiperazin-1- yl]-5,6-dimethyl-2-(morpholin-4-ylmethyl)thie no[2,3-d]pyrimidine
  • MW: 515.691 | Formula: C25H33N5O3S2
  • H donors: 0 H acceptors: 4 LogP: 3.62 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: Cc1ccc(c(c1)S(=O)(=O)N1CCN(CC1)c1nc(CN2CCOCC2)nc2c1c(C)c(s2)C)C
  • InChi: 1S/C25H33N5O3S2/c1-17-5-6-18(2)21(15-17)35(31,32)30-9-7-29(8-10-30)24-23-19(3)20(4)34-25(23)27-22(26-24)16-28-11-13-33-14-12-28/h5-6,15H,7-14,16H2,1-4H3
  • InChiKey: XOKCGINQNSELOX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[4-(2,5-dimethylphenyl)sulfonylpiperazin-1-yl]-5,6-dimethyl-2-(morpholinomethyl)thieno[2,3-d]pyrimidine
  • 4-[4-(2,5-dimethylphenyl)sulfonyl-1-piperazinyl]-5,6-dimethyl-2-(morpholinomethyl)thieno[2,3-d]pyrimidine
  • T5301851

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0008 0.003 0.0052
Onchocerca volvulus 0.0073 0.0691 0.2874
Echinococcus granulosus beta catenin 0.01 0.0967 0.1751
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0008 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0008 0.003 0.0029
Trichomonas vaginalis ran, putative 0.0022 0.0167 0.0624
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0126 0.0227
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0073 0.0691 0.125
Schistosoma mansoni nuclear hormone receptor 0.0008 0.003 0.0068
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0305 0.7455
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0126 0.0296
Brugia malayi ORL1-like opioid receptor 0.0073 0.0691 0.2599
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0167 0.0166
Brugia malayi transcription factor E74 isoform 0.001 0.0051 0.0189
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0691 0.069
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0012 0.0042
Echinococcus granulosus neuropeptide FF receptor 2 0.0073 0.0691 0.125
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0073 0.0691 0.125
Echinococcus granulosus ETS transcription factor Elf 1 0.001 0.0051 0.0091
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0008 0.003 0.0052
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.039 0.1467
Loa Loa (eye worm) hypothetical protein 0.0008 0.003 0.0029
Schistosoma mansoni hypothetical protein 0.0143 0.1414 0.3338
Echinococcus granulosus histone acetyltransferase KAT2B 0.0149 0.1473 0.2667
Loa Loa (eye worm) melatonin receptor type 1A 0.0073 0.0691 0.0693
Onchocerca volvulus Bile acid receptor homolog 0.0018 0.0126 0.042
Onchocerca volvulus 0.0073 0.0691 0.2874
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0691 0.1628
Schistosoma mansoni hypothetical protein 0.001 0.0051 0.0119
Echinococcus granulosus ETS domain containing protein Elk 1 0.001 0.0051 0.0091
Echinococcus granulosus thyroid hormone receptor alpha 0.0008 0.003 0.0052
Schistosoma mansoni hypothetical protein 0.0418 0.4236 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0511 0.1204
Loa Loa (eye worm) hypothetical protein 0.0008 0.003 0.0029
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0126 0.0227
Schistosoma mansoni pangolin 0.0067 0.0628 0.148
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0073 0.0691 0.0693
Loa Loa (eye worm) hypothetical protein 0.0018 0.0126 0.0126
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0126 0.0126
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0347 0.8885
Echinococcus multilocularis fmrfamide receptor 0.0073 0.0691 0.069
Loa Loa (eye worm) neuropeptide F receptor 0.0073 0.0691 0.0693
Schistosoma mansoni ets-related 0.001 0.0051 0.0119
Loa Loa (eye worm) hypothetical protein 0.0008 0.003 0.0029
Brugia malayi hypothetical protein 0.0008 0.003 0.0109
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0146 0.2732
Schistosoma mansoni biogenic amine receptor 0.0073 0.0691 0.1628
Schistosoma mansoni opsin-like receptor 0.0073 0.0691 0.1628
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0208 0.5325
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0391
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0245 0.0245
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0208 0.4593
Schistosoma mansoni hypothetical protein 0.0066 0.0625 0.1472
Loa Loa (eye worm) hypothetical protein 0.0026 0.0208 0.0208
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0391
Schistosoma mansoni opsin-like receptor 0.0073 0.0691 0.1628
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0073 0.0691 0.069
Brugia malayi nuclear receptor NHR-67 0.0008 0.003 0.0109
Schistosoma mansoni adenoreceptor 0.0073 0.0691 0.1628
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0315 0.3174 0.3189
Schistosoma mansoni inositol monophosphatase 0.0039 0.0347 0.0817
Echinococcus granulosus GPCR family 2 0.0066 0.0625 0.113
Echinococcus multilocularis G protein coupled receptor 139 0.0073 0.0691 0.069
Schistosoma mansoni ran 0.0022 0.0167 0.0391
Loa Loa (eye worm) histone methyltransferase 0.001 0.0048 0.0047
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0126 0.0125
Echinococcus multilocularis ets variant gene 4 0.001 0.0051 0.005
Schistosoma mansoni growth hormone secretagogue receptor 0.0073 0.0691 0.1628
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Echinococcus multilocularis neuropeptide receptor A26 0.0543 0.5518 0.5518
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0209 0.2095 0.2105
Schistosoma mansoni beta-catenin 0.01 0.0967 0.2282
Schistosoma mansoni hypothetical protein 0.0073 0.0691 0.1628
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0073 0.0691 0.1628
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.1818 0.6848
Onchocerca volvulus Glucosylceramidase homolog 0.0173 0.1722 0.7361
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0073 0.0691 0.069
Brugia malayi hypothetical protein 0.0073 0.0691 0.2599
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0073 0.0691 0.0693
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0511 0.1923
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.0685 0.0684
Echinococcus multilocularis ETS transcription factor Elf 1 0.001 0.0051 0.005
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.039 0.0706
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0691 0.1628
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0347 0.614
Schistosoma mansoni neuropeptide receptor 0.0073 0.0691 0.1628
Brugia malayi ecdysteroid receptor 0.0018 0.0126 0.0472
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0189 0.0709
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0126 0.0472
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0208 0.5652
Brugia malayi Cytochrome P450 family protein 0.002 0.0146 0.0545
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0126 0.0227
Brugia malayi Cytochrome P450 family protein 0.002 0.0146 0.0545
Brugia malayi G-protein coupled receptor 0.0073 0.0691 0.2599
Echinococcus granulosus tm gpcr rhodopsin 0.0073 0.0691 0.125
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.025 0.0588
Schistosoma mansoni alpha-1 adrenergic receptor 0.0073 0.0691 0.1628
Brugia malayi conserved hypotetical protein 0.0008 0.003 0.0109
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1722 0.6487
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0073 0.0691 0.0693
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0126 0.0472
Brugia malayi ecdysone receptor 0.0008 0.003 0.0109
Schistosoma mansoni hypothetical protein 0.0066 0.0625 0.1472
Echinococcus granulosus allatostatin A receptor 0.0073 0.0691 0.125
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0073 0.0691 0.1628
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0009 0.004 0.0039
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0009 0.004 0.0071
Brugia malayi Ets-domain containing protein 0.0072 0.0685 0.2577
Loa Loa (eye worm) G-protein coupled receptor 0.0073 0.0691 0.0693
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0511 0.051
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0167 0.2938
Brugia malayi DNA-binding protein D-ETS-3 0.001 0.0051 0.0189
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0126 0.0472
Schistosoma mansoni hypothetical protein 0.001 0.0051 0.0119
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Brugia malayi AKH receptor 0.0073 0.0691 0.2599
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.003 0.0068
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0073 0.0691 0.069
Leishmania major GTP-binding protein, putative 0.0022 0.0167 0.4251
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.0042
Echinococcus granulosus fmrfamide receptor 0.0073 0.0691 0.125
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0073 0.0691 0.1628
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0691 0.069
Brugia malayi nuclear receptor NHR-88 0.0018 0.0126 0.0472
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Loa Loa (eye worm) hypothetical protein 0.0018 0.0126 0.0126
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0054 0.0053
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.001 0.0051 0.0119
Onchocerca volvulus 0.0043 0.039 0.1568
Echinococcus granulosus g protein coupled receptor 0.0073 0.0691 0.125
Loa Loa (eye worm) hypothetical protein 0.0018 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.039 1
Echinococcus granulosus neuropeptide Y receptor 0.0073 0.0691 0.125
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1722 0.6487
Schistosoma mansoni cytochrome P450 0.0011 0.0054 0.0124
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0073 0.0691 0.069
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0368 1
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0246 0.4356
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.2654 1
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0146 0.2732
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.039 0.1467
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0391
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0011 0.0054 0.1354
Loa Loa (eye worm) HMG box family protein 0.0067 0.0628 0.063
Loa Loa (eye worm) nuclear hormone receptor 0.0008 0.003 0.0029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0691 0.069
Onchocerca volvulus 0.0073 0.0691 0.2874
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.039 0.1227
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.003 0.0029
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.003 0.0029
Mycobacterium ulcerans hypothetical protein 0.0043 0.039 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0008 0.003 0.0029
Echinococcus granulosus dro:myosuppressin receptor 0.0073 0.0691 0.125
Onchocerca volvulus 0.0073 0.0691 0.2874
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0146 0.2732
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.025 0.0249
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0126 0.0472
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0391
Onchocerca volvulus 0.0073 0.0691 0.2874
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0208 0.368
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.2654 1
Onchocerca volvulus 0.0073 0.0691 0.2874
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.025 0.0588
Brugia malayi hypothetical protein 0.0073 0.0691 0.2599
Loa Loa (eye worm) ets-domain-containing protein 0.001 0.0051 0.005
Loa Loa (eye worm) hypothetical protein 0.0066 0.0625 0.0627
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Loa Loa (eye worm) hypothetical protein 0.0008 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Brugia malayi G protein-coupled receptor F59B2.13 0.0073 0.0691 0.2599
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Brugia malayi hypothetical protein 0.0026 0.0208 0.0781
Echinococcus multilocularis g protein coupled receptor 0.0073 0.0691 0.069
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.039 1
Loa Loa (eye worm) cytochrome P450 0.0011 0.0054 0.0053
Leishmania major hypothetical protein, conserved 0.0026 0.0208 0.5325
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0167 0.4098
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Leishmania major importin beta-1 subunit, putative 0.0024 0.0189 0.4833
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0126 0.0227
Onchocerca volvulus 0.0073 0.0691 0.2874
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0126 0.0472
Echinococcus multilocularis 0.0011 0.0054 0.0053
Schistosoma mansoni inositol monophosphatase 0.0039 0.0347 0.0817
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0691 0.1628
Brugia malayi Pre-SET motif family protein 0.003 0.025 0.0939
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0564 1
Entamoeba histolytica hypothetical protein 0.0024 0.0189 0.5129
Plasmodium vivax hypothetical protein, conserved 0.0043 0.039 0.9606
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0691 0.069
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Echinococcus granulosus T cell transcription factor 4 long C terminal 0.0067 0.0628 0.1136
Brugia malayi Inositol-1 0.0039 0.0347 0.1304
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0073 0.0691 0.069
Plasmodium vivax importin-beta 2, putative 0.0029 0.0246 0.6064
Onchocerca volvulus 0.0073 0.0691 0.2874
Brugia malayi RE15519p 0.0073 0.0691 0.2599
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0347 0.871
Brugia malayi sulfakinin receptor protein 0.0073 0.0691 0.2599
Mycobacterium leprae Probable lipase LipE 0.0043 0.039 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.003 0.0029
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0126 0.0227
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0126 0.0227
Brugia malayi HMG box family protein 0.0067 0.0628 0.2363
Schistosoma mansoni importin beta-1 0.0029 0.0246 0.0579
Brugia malayi acetyltransferase, GNAT family protein 0.0153 0.1517 0.5713
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0691 0.1628
Schistosoma mansoni coup transcription factor 0.0018 0.0126 0.0296
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0073 0.0691 0.1628
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0189 0.4024
Loa Loa (eye worm) TYRA-2 protein 0.0073 0.0691 0.0693
Brugia malayi G-protein coupled receptor 0.0073 0.0691 0.2599
Brugia malayi Serotonin receptor 0.0073 0.0691 0.2599
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0012 0.0042
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.039 1
Mycobacterium tuberculosis Conserved protein 0.0043 0.039 0.1227
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0691 0.125
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.1818 0.6848
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0126 0.0296
Echinococcus multilocularis allatostatin A receptor 0.0073 0.0691 0.069
Echinococcus granulosus serotonin receptor 0.0073 0.0691 0.125
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0073 0.0691 0.125
Brugia malayi GnHR receptor homolog 0.0073 0.0691 0.2599
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0189 0.0709
Brugia malayi nuclear receptor RXR 0.0009 0.004 0.0148
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.039 0.1467
Echinococcus granulosus neuropeptide receptor 0.0073 0.0691 0.125
Brugia malayi Pre-SET motif family protein 0.0204 0.204 0.7685
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0153 0.1517 0.1516
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0073 0.0691 0.125
Loa Loa (eye worm) hypothetical protein 0.0008 0.003 0.0029
Brugia malayi orphan nuclear receptor NR2E1 0.0008 0.003 0.0109
Loa Loa (eye worm) nuclear receptor NHR-67 0.0008 0.003 0.0029
Loa Loa (eye worm) fli-1 protein 0.0219 0.2193 0.2203
Echinococcus multilocularis ETS transcription factor Elf 5 0.001 0.0051 0.005
Onchocerca volvulus 0.0073 0.0691 0.2874
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0011 0.0054 0.1354
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0126 0.0126
Schistosoma mansoni neuropeptide receptor 0.0073 0.0691 0.1628
Plasmodium vivax SET domain protein, putative 0.003 0.025 0.6155
Echinococcus multilocularis neuropeptide Y receptor 0.0073 0.0691 0.069
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0368 1
Brugia malayi hypothetical protein 0.0008 0.003 0.0109
Brugia malayi nuclear receptor RXR 0.0008 0.003 0.0109
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0691 0.125
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0347 0.1304
Brugia malayi Latrophilin receptor protein 2 0.0066 0.0625 0.235
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0073 0.0691 0.1628
Echinococcus granulosus g protein coupled receptor 0.0073 0.0691 0.125
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.0042
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0047 0.0173
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0347 0.871
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.0685 0.0687
Mycobacterium tuberculosis Conserved protein 0.0043 0.039 0.1227
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.039 0.0919
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0406 0.0735
Brugia malayi nuclear hormone receptor family member nhr-6 0.0008 0.003 0.0109
Loa Loa (eye worm) hypothetical protein 0.0009 0.0036 0.0035
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.039 0.1227
Loa Loa (eye worm) hypothetical protein 0.0009 0.004 0.0039
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.004 0.0093
Leishmania major cytochrome p450-like protein 0.0011 0.0054 0.1354
Brugia malayi hypothetical protein 0.0073 0.0691 0.2599
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Echinococcus multilocularis protein pangolin J 0.0067 0.0628 0.0627
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0347 0.8885
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Brugia malayi hypothetical protein 0.0017 0.0115 0.0428
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.0625 0.0627
Leishmania major cytochrome p450-like protein 0.0011 0.0054 0.1354
Echinococcus multilocularis sex peptide receptor 0.0073 0.0691 0.069
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.0625 0.113
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0126 0.0227
Schistosoma mansoni neuropeptide F-like receptor 0.0073 0.0691 0.1628
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.039 0.0391
Echinococcus granulosus neuropeptide receptor 0.0073 0.0691 0.125
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0208 0.4593
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0008 0.003 0.0029
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0691 0.069
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0691 0.069
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.0042
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0347 0.871
Brugia malayi Calcitonin receptor-like protein seb-1 0.0209 0.2095 0.7894
Brugia malayi hypothetical protein 0.0073 0.0691 0.2599
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0126 0.0126
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0051 0.0091
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0008 0.003 0.0029
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0511 0.0924
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1722 0.6487
Loa Loa (eye worm) hypothetical protein 0.0009 0.004 0.0039
Brugia malayi hypothetical protein 0.0073 0.0691 0.2599
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.039 0.1227
Echinococcus multilocularis neuropeptide Y receptor 0.0073 0.0691 0.069
Echinococcus multilocularis dro:myosuppressin receptor 0.0073 0.0691 0.069
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0594 0.14
Brugia malayi follicle stimulating hormone receptor 0.0073 0.0691 0.2599
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Onchocerca volvulus 0.0029 0.0245 0.0936
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0048 0.0047
Echinococcus multilocularis G-protein coupled receptor, putative 0.0073 0.0691 0.069
Loa Loa (eye worm) hypothetical protein 0.0018 0.0126 0.0126
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0126 0.0472
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Schistosoma mansoni ets 0.001 0.0051 0.0119
Echinococcus granulosus biogenic amine 5HT receptor 0.0073 0.0691 0.125
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.2654 1
Brugia malayi cytochrome P450 0.0011 0.0054 0.0199
Brugia malayi Tachykinin-like peptides receptor 99D 0.0073 0.0691 0.2599
Brugia malayi Nuclear hormone receptor E75 0.0008 0.003 0.0109
Echinococcus multilocularis somatostatin receptor 0.0073 0.0691 0.069
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.004 0.0148
Brugia malayi G protein-coupled receptor 0.0073 0.0691 0.2599
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0246 0.6303
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0126 0.0126
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0305 0.0915
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0126 0.0472
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0126 0.0227
Echinococcus granulosus Nuclear hormone receptor HR96 0.0008 0.003 0.0052
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0691 0.069
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0511 0.0513
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.039 0.1467
Schistosoma mansoni biogenic amine (5HT) receptor 0.0073 0.0691 0.1628
Loa Loa (eye worm) hypothetical protein 0.003 0.025 0.025
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.0625 0.235
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0511 0.0924
Echinococcus granulosus tm gpcr rhodopsin 0.0073 0.0691 0.125
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.0042
Schistosoma mansoni hypothetical protein 0.0315 0.3174 0.7492
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0051 0.0091
Brugia malayi steroid hormone receptor 0.0018 0.0126 0.0472
Leishmania major hypothetical protein, conserved 0.0043 0.039 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.025 0.0249
Brugia malayi Cytochrome P450 family protein 0.0011 0.0054 0.0199
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0073 0.0691 0.069
Brugia malayi Melatonin receptor type 1A 0.0073 0.0691 0.2599
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.0042
Echinococcus multilocularis nuclear receptor nhr 48 0.0008 0.003 0.0029
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0406 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0691 0.1628
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Brugia malayi Dopamine receptor 0.0073 0.0691 0.2599
Loa Loa (eye worm) hypothetical protein 0.0009 0.004 0.0039
Schistosoma mansoni cpg binding protein 0.0029 0.0245 0.0576
Schistosoma mansoni nuclear hormone receptor 0.0008 0.003 0.0068
Brugia malayi beta-lactamase family protein 0.0043 0.039 0.1467
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0691 0.1628
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0073 0.0691 0.069
Brugia malayi latrophilin 2 splice variant baaae 0.0143 0.1414 0.5328
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0246 0.6303
Echinococcus granulosus geminin 0.0173 0.1722 0.3119
Schistosoma mansoni amine GPCR 0.0073 0.0691 0.1628
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0126 0.0126
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0073 0.0691 0.069
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0073 0.0691 0.069
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0126 0.0296
Onchocerca volvulus 0.003 0.025 0.0958
Schistosoma mansoni biogenic amine (5HT) receptor 0.0073 0.0691 0.1628
Echinococcus granulosus importin subunit beta 1 0.0029 0.0246 0.0445
Onchocerca volvulus 0.0232 0.2328 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.0042
Brugia malayi hypothetical protein 0.0073 0.0691 0.2599
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0073 0.0691 0.1628
Echinococcus multilocularis neuropeptide receptor 0.0073 0.0691 0.069
Trypanosoma brucei cytochrome P450, putative 0.002 0.0146 0.3716
Brugia malayi hypothetical protein 0.0073 0.0691 0.2599
Echinococcus granulosus 7tm_1 domain containing protein 0.0073 0.0691 0.125
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.004 0.0148
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.003 0.0052
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0048 0.0085
Schistosoma mansoni neuropeptide receptor 0.0073 0.0691 0.1628
Echinococcus multilocularis T cell transcription factor 4 long C terminal 0.0067 0.0628 0.0627
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0012 0.0042
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0066 0.0625 0.113
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.039 0.1227
Echinococcus granulosus alpha 1A adrenergic receptor 0.0073 0.0691 0.125
Loa Loa (eye worm) hypothetical protein 0.0018 0.0126 0.0126
Echinococcus granulosus somatostatin receptor 0.0073 0.0691 0.125
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0126 0.0125
Brugia malayi Importin beta-1 subunit 0.0029 0.0246 0.0925
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.2796 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0012 0.0042
Brugia malayi neuropeptide F receptor 0.0073 0.0691 0.2599
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1722 0.6487
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.2654 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0073 0.0691 0.125
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0691 0.1628
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0167 0.335
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0347 0.5
Schistosoma mansoni zinc finger protein 0.0008 0.003 0.0068
Onchocerca volvulus 0.0018 0.0126 0.042
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0073 0.0691 0.1628
Echinococcus multilocularis orexin receptor type 2 0.0073 0.0691 0.069
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0511 0.1204
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0073 0.0691 0.0693
Echinococcus granulosus hypothetical protein 0.0309 0.3113 0.5641
Loa Loa (eye worm) inositol-1 0.0039 0.0347 0.0348
Schistosoma mansoni nuclear receptor 0.0008 0.003 0.0068
Loa Loa (eye worm) hypothetical protein 0.0008 0.003 0.0029
Schistosoma mansoni hypothetical protein 0.0073 0.0691 0.1628
Loa Loa (eye worm) D-ets-2 protein 0.001 0.0051 0.005
Entamoeba histolytica Ran family GTPase 0.0022 0.0167 0.4512
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0347 0.0346
Loa Loa (eye worm) hypothetical protein 0.0009 0.004 0.0039
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0153 0.1517 0.3579
Brugia malayi beta-lactamase 0.0043 0.039 0.1467
Loa Loa (eye worm) hypothetical protein 0.0974 0.9951 1
Schistosoma mansoni biogenic amine receptor 0.0073 0.0691 0.1628
Schistosoma mansoni myosin xvIII 0.0073 0.0691 0.1628
Schistosoma mansoni elf1 0.001 0.0051 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0126 0.0472
Echinococcus granulosus ETS transcription factor Elf 5 0.001 0.0051 0.0091
Brugia malayi RNA, U transporter 1 0.0084 0.0804 0.3028
Loa Loa (eye worm) beta-lactamase 0.0043 0.039 0.0391
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.039 1
Echinococcus multilocularis ewsr:fli fusion protein type 0.001 0.0051 0.005
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.039 0.1467
Loa Loa (eye worm) hypothetical protein 0.0008 0.003 0.0029
Schistosoma mansoni ran 0.0022 0.0167 0.0391
Echinococcus multilocularis ETS domain containing protein Elk 1 0.001 0.0051 0.005
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0167 0.4512
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0347 0.0627
Loa Loa (eye worm) hypothetical protein 0.0209 0.2095 0.2105
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0126 0.0296
Schistosoma mansoni hypothetical protein 0.0173 0.1722 0.4064
Echinococcus granulosus pangolin 0.0067 0.0628 0.1136
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Echinococcus granulosus biogenic amine 5HT receptor 0.0073 0.0691 0.125
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0073 0.0691 0.125
Loa Loa (eye worm) hypothetical protein 0.0008 0.003 0.0029
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0511 0.1204
Schistosoma mansoni hypothetical protein 0.0066 0.0625 0.1472
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0073 0.0691 0.1628
Brugia malayi hypothetical protein 0.0073 0.0691 0.2599
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0012 0.0042
Mycobacterium tuberculosis Conserved protein 0.0043 0.039 0.1227
Onchocerca volvulus 0.0043 0.039 0.1568
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0126 0.0296
Mycobacterium ulcerans beta-lactamase 0.0043 0.039 1
Schistosoma mansoni hypothetical protein 0.0011 0.0054 0.0124
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Onchocerca volvulus Protein ultraspiracle homolog 0.0018 0.0126 0.042
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0126 0.0472
Loa Loa (eye worm) neuropeptide F receptor 0.0073 0.0691 0.0693
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0073 0.0691 0.2599
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0126 0.0125
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0126 0.0472
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0008 0.003 0.0068
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0018 0.0126 0.042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0126 0.0126
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0126 0.0126
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.0126 0.0125
Brugia malayi hypothetical protein 0.0009 0.004 0.0148
Brugia malayi Fli-1 protein 0.0219 0.2193 0.8264
Loa Loa (eye worm) hypothetical protein 0.0009 0.004 0.0039
Brugia malayi putative neuropeptide receptor NPR1 0.0073 0.0691 0.2599
Schistosoma mansoni neuropeptide receptor 0.0073 0.0691 0.1628
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0126 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.0042
Echinococcus multilocularis dnaJ subfamily B 0.0418 0.4236 0.4235
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0167 0.0624
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0073 0.0691 0.0693
Plasmodium vivax transportin, putative 0.0006 0.0001 0.0027
Brugia malayi neuropeptide F receptor 0.0073 0.0691 0.2599
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0126 0.0296
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0246 0.0245
Brugia malayi nuclear hormone receptor family member odr-7 0.0008 0.003 0.0109
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0691 0.125
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0073 0.0691 0.2599
Echinococcus multilocularis neuropeptides capa receptor 0.0073 0.0691 0.069
Mycobacterium leprae conserved hypothetical protein 0.0043 0.039 1
Echinococcus multilocularis serotonin receptor 0.0073 0.0691 0.069
Toxoplasma gondii ABC1 family protein 0.0043 0.039 0.6911
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0054 0.0096
Schistosoma mansoni hypothetical protein 0.0243 0.2435 0.5748
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0167 0.0165
Schistosoma mansoni opsin-like receptor 0.0073 0.0691 0.1628
Echinococcus granulosus orexin receptor type 2 0.0073 0.0691 0.125
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0691 0.1628
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0126 0.0472
Echinococcus multilocularis protein C ets 2 0.001 0.0051 0.005
Trichomonas vaginalis esterase, putative 0.0043 0.039 0.1467
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1722 0.6487
Echinococcus granulosus g-protein coupled receptor 0.0073 0.0691 0.125
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0189 0.0709
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0368 1
Schistosoma mansoni nuclear receptor nhr-48 0.0008 0.003 0.0068
Onchocerca volvulus 0.0073 0.0691 0.2874
Mycobacterium ulcerans lipase LipD 0.0043 0.039 1
Loa Loa (eye worm) hypothetical protein 0.0974 0.9951 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0126 0.0227
Echinococcus multilocularis GPCR, family 2 0.0066 0.0625 0.0624
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1722 0.6487
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0073 0.0691 0.125
Onchocerca volvulus 0.0043 0.039 0.1568
Echinococcus granulosus neuropeptides capa receptor 0.0073 0.0691 0.125
Schistosoma mansoni hypothetical protein 0.0173 0.1722 0.4064
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0073 0.0691 0.2599
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0167 0.335
Echinococcus multilocularis neuropeptide receptor 0.0073 0.0691 0.069
Brugia malayi larval opioid receptor 0.0073 0.0691 0.2599
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0691 0.125
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0126 0.0296
Brugia malayi nuclear receptor NHR-88 0.0008 0.003 0.0109
Onchocerca volvulus 0.0073 0.0691 0.2874
Echinococcus granulosus sex peptide receptor 0.0073 0.0691 0.125
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0062 0.0061
Schistosoma mansoni nuclear receptor 0.0008 0.003 0.0068
Schistosoma mansoni hypothetical protein 0.0073 0.0691 0.1628
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.2654 1
Echinococcus granulosus dnaJ subfamily B 0.0418 0.4236 0.7676
Loa Loa (eye worm) hypothetical protein 0.0029 0.0246 0.0247
Onchocerca volvulus Cirhin homolog 0.0099 0.096 0.4048
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Loa Loa (eye worm) hypothetical protein 0.0008 0.003 0.0029
Brugia malayi putative neuropeptide receptor 0.0073 0.0691 0.2599
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0073 0.0691 0.069
Schistosoma mansoni hypothetical protein 0.0073 0.0691 0.1628
Schistosoma mansoni histamine h1 receptor 0.0073 0.0691 0.1628
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1722 0.6487
Echinococcus granulosus tm gpcr rhodopsin 0.0073 0.0691 0.125
Loa Loa (eye worm) hypothetical protein 0.0018 0.0126 0.0126
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0073 0.0691 0.069
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0406 0.1528
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0233 0.0419
Onchocerca volvulus 0.0073 0.0691 0.2874
Loa Loa (eye worm) G-protein coupled receptor 0.0073 0.0691 0.0693
Onchocerca volvulus 0.0073 0.0691 0.2874
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0073 0.0691 0.1628
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0012 0.0042
Schistosoma mansoni biogenic amine receptor 0.0073 0.0691 0.1628
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0051 0.005
Brugia malayi Cytochrome P450 family protein 0.0011 0.0054 0.0199
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0691 0.125
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0126 0.0472
Brugia malayi tailless protein 0.0008 0.003 0.0109
Brugia malayi Ets-domain containing protein 0.0072 0.0685 0.2577
Echinococcus granulosus peptide allatostatin:somatostatin 0.0073 0.0691 0.125
Loa Loa (eye worm) hypothetical protein 0.0008 0.003 0.0029
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0073 0.0691 0.1628
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0051 0.005
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0691 0.125
Brugia malayi hypothetical protein 0.0009 0.004 0.0148
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Echinococcus multilocularis g protein coupled receptor 0.0073 0.0691 0.069
Onchocerca volvulus 0.0073 0.0691 0.2874
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0126 0.0472
Echinococcus multilocularis neuropeptide FF receptor 2 0.0073 0.0691 0.069
Brugia malayi hypothetical protein 0.0073 0.0691 0.2599
Brugia malayi Dopamine receptor protein 2 0.0073 0.0691 0.2599
Echinococcus granulosus g protein coupled receptor 0.0073 0.0691 0.125
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0073 0.0691 0.2599
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0073 0.0691 0.1628
Echinococcus multilocularis g-protein coupled receptor 0.0073 0.0691 0.069
Echinococcus granulosus nuclear receptor nhr 48 0.0008 0.003 0.0052
Schistosoma mansoni cpg binding protein 0.0031 0.0262 0.0617
Onchocerca volvulus 0.0073 0.0691 0.2874
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Echinococcus multilocularis geminin 0.0173 0.1722 0.1721
Echinococcus granulosus G protein coupled receptor 139 0.0073 0.0691 0.125
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.0685 0.1239
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.039 0.1227
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0073 0.0691 0.1628
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0073 0.0691 0.1628
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0264 0.2654 1
Schistosoma mansoni amine GPCR 0.0073 0.0691 0.1628
Schistosoma mansoni amine GPCR 0.0073 0.0691 0.1628
Echinococcus granulosus snurportin 1 0.0315 0.3174 0.5751
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.0625 0.0624
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0511 0.051
Echinococcus granulosus neuropeptides capa receptor 0.0073 0.0691 0.125
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.039 0.1227
Loa Loa (eye worm) hypothetical protein 0.0008 0.003 0.0029
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.039 0.0389
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0126 0.0125
Onchocerca volvulus 0.0073 0.0691 0.2874
Loa Loa (eye worm) hypothetical protein 0.0018 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0391
Echinococcus multilocularis neuropeptides capa receptor 0.0073 0.0691 0.069
Schistosoma mansoni gabp alpha 0.0072 0.0685 0.1614
Brugia malayi nuclear hormone receptor 0.0018 0.0126 0.0472
Echinococcus multilocularis beta catenin 0.01 0.0967 0.0966
Loa Loa (eye worm) hypothetical protein 0.0143 0.1414 0.142
Echinococcus multilocularis serotonin receptor 0.0073 0.0691 0.069
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0073 0.0691 0.2874
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0126 0.0472
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.025 0.0588
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0126 0.0296
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0126 0.0472
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0009 0.004 0.0093
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0073 0.0691 0.069
Echinococcus multilocularis snurportin 1 0.0315 0.3174 0.3173
Loa Loa (eye worm) DR-78 0.0008 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0018 0.0126 0.0126
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0126 0.0296
Echinococcus granulosus neuropeptide s receptor 0.0543 0.5518 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Echinococcus multilocularis cpg binding protein 0.0031 0.0262 0.0261
Schistosoma mansoni neuropeptide F-like receptor 0.0073 0.0691 0.1628
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0126 0.0125
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0208 0.5652
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0008 0.003 0.0029
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.039 0.1227
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0008 0.003 0.0068
Onchocerca volvulus Neuropeptide F receptor homolog 0.0073 0.0691 0.2874
Toxoplasma gondii cytochrome p450 superfamily protein 0.0011 0.0054 0.0936
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.039 0.1467
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.025 0.0588
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0062 0.0111
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.025 0.4421
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0126 0.0125
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0073 0.0691 0.2599
Loa Loa (eye worm) hypothetical protein 0.0062 0.0577 0.0579
Echinococcus granulosus ewsr:fli fusion protein type 0.001 0.0051 0.0091
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0406 0.1528
Schistosoma mansoni hypothetical protein 0.0012 0.0062 0.0145
Echinococcus granulosus Nuclear hormone receptor HR96 0.0008 0.003 0.0052
Trichomonas vaginalis set domain proteins, putative 0.0232 0.2328 0.8773
Onchocerca volvulus 0.0073 0.0691 0.2874
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0073 0.0691 0.1628
Plasmodium falciparum importin beta, putative 0.0029 0.0246 0.669
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0264 0.2654 0.2666
Echinococcus granulosus neuropeptide Y receptor 0.0073 0.0691 0.125
Schistosoma mansoni neuropeptide f receptor 76f 0.0073 0.0691 0.1628
Echinococcus granulosus 7TM GPCR rhodopsin 0.0073 0.0691 0.125
Brugia malayi Serotonin receptor 0.0073 0.0691 0.2599
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.039 0.0919
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0406 0.7195
Loa Loa (eye worm) CYP4Cod1 0.002 0.0146 0.0145
Brugia malayi Armadillo/beta-catenin-like repeat family protein 0.01 0.0967 0.3642
Echinococcus granulosus protein C ets 2 0.001 0.0051 0.0091
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0347 0.1304
Loa Loa (eye worm) hypothetical protein 0.001 0.0051 0.005
Loa Loa (eye worm) HMP-2 protein 0.01 0.0967 0.0971
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0406 0.7195
Echinococcus granulosus rhodopsin orphan GPCR 0.0073 0.0691 0.125
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0066 0.0625 0.0624
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0347 0.1304
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.003 0.0052
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.204 0.2049
Echinococcus granulosus cpg binding protein 0.0031 0.0262 0.0474
Brugia malayi nuclear hormone receptor 0.0008 0.003 0.0109
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0146 0.0145
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0012 0.0042
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.025 0.0451
Echinococcus multilocularis neuropeptide s receptor 0.0543 0.5518 0.5518
Echinococcus multilocularis fmrfamide receptor 0.0073 0.0691 0.069
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0167 0.4251
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0126 0.0296
Echinococcus granulosus neuropeptide receptor A26 0.0543 0.5518 1
Echinococcus granulosus hypothetical protein 0.0073 0.0691 0.125
Trichomonas vaginalis helicase, putative 0.0007 0.0012 0.0042
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0073 0.0691 0.069
Loa Loa (eye worm) hypothetical protein 0.0043 0.039 0.0391
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Brugia malayi CXXC zinc finger family protein 0.0029 0.0245 0.092
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0347 0.943
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Echinococcus multilocularis rhodopsin orphan GPCR 0.0073 0.0691 0.069
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.0042
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0073 0.0691 0.069
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.001 0.0051 0.005
Schistosoma mansoni hypothetical protein 0.0066 0.0625 0.1472
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0167 0.03
Brugia malayi Nuclear hormone receptor E75 0.0008 0.003 0.0109
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0208 0.5127
Schistosoma mansoni cpg binding protein 0.0031 0.0262 0.0617
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0126 0.0296
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0009 0.004 0.0039
Loa Loa (eye worm) acetyltransferase 0.0153 0.1517 0.1523
Brugia malayi beta-lactamase family protein 0.0043 0.039 0.1467
Brugia malayi hypothetical protein 0.0073 0.0691 0.2599
Schistosoma mansoni thyroid hormone receptor 0.0018 0.0126 0.0296
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0209 0.2095 0.7894
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0126 0.0472
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.001 0.0051 0.005
Brugia malayi Ets-domain containing protein 0.001 0.0051 0.0189
Echinococcus multilocularis g protein coupled receptor 0.0073 0.0691 0.069
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.039 1
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0146 0.0145
Schistosoma mansoni amine GPCR 0.0073 0.0691 0.1628
Loa Loa (eye worm) hypothetical protein 0.001 0.0051 0.005
Brugia malayi Dopamine receptor protein 1 0.0073 0.0691 0.2599
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.0042
Schistosoma mansoni amine GPCR 0.0073 0.0691 0.1628
Schistosoma mansoni ets-related 0.0219 0.2193 0.5176
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.2654 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0008 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0073 0.0691 0.0693
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0126 0.0125
Leishmania major cytochrome p450-like protein 0.002 0.0146 0.3716
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0126 0.0125
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0012 0.0042
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0008 0.003 0.0109

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.3489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 112.2018 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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