Detailed information for compound 1242413

Basic information

Technical information
  • TDR Targets ID: 1242413
  • Name: N-(2,3-dimethylquinoxalin-6-yl)-4-methylpiper idine-1-carbothioamide
  • MW: 314.448 | Formula: C17H22N4S
  • H donors: 0 H acceptors: 2 LogP: 3.51 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCN(CC1)C(=Nc1ccc2c(c1)nc(c(n2)C)C)S
  • InChi: 1S/C17H22N4S/c1-11-6-8-21(9-7-11)17(22)20-14-4-5-15-16(10-14)19-13(3)12(2)18-15/h4-5,10-11H,6-9H2,1-3H3,(H,20,22)
  • InChiKey: GLRJYEQAQWEQIO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,3-dimethylquinoxalin-6-yl)-4-methyl-piperidine-1-carbothioamide
  • N-(2,3-dimethyl-6-quinoxalinyl)-4-methyl-1-piperidinecarbothioamide
  • MLS000710432
  • SMR000280199
  • Oprea1_682225
  • 4-Methyl-piperidine-1-carbothioic acid (2,3-dimethyl-quinoxalin-6-yl)-amide
  • BAS 01991447
  • ZINC00302529
  • BIM-0035455.P001
  • CBMicro_035264

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0067 0.0228 0.0532
Brugia malayi Animal haem peroxidase family protein 0.0038 0.0098 0.0211
Trypanosoma brucei carbonic anhydrase-like protein 0.0937 0.4223 1
Schistosoma mansoni cpg binding protein 0.0065 0.0219 0.051
Echinococcus multilocularis polycomb protein SCMH1 0.0055 0.0176 0.0403
Loa Loa (eye worm) hypothetical protein 0.0042 0.0113 0.0258
Plasmodium falciparum glutathione reductase 0.0019 0.0009 0.0023
Onchocerca volvulus 0.0042 0.0113 0.0448
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0009 0.0009
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0113 0.0104
Loa Loa (eye worm) hypothetical protein 0.0038 0.0098 0.0221
Toxoplasma gondii exonuclease III APE 0.002 0.0012 0.0014
Loa Loa (eye worm) hypothetical protein 0.0038 0.0098 0.0221
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0139 0.0559 0.0617
Trichomonas vaginalis conserved hypothetical protein 0.2195 1 1
Schistosoma mansoni hypothetical protein 0.0019 0.0009 0.0015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1543 0.1535
Schistosoma mansoni cpg binding protein 0.0065 0.0219 0.051
Mycobacterium tuberculosis Probable dehydrogenase 0.0125 0.0495 0.0546
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0135 0.054 0.0596
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0009 0.0014
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0032 0.0028
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0015 0.0015
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0009 0.0009
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0125 0.0497 0.1169
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0009 0.0014
Brugia malayi Thioredoxin reductase 0.0055 0.0173 0.0391
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0032 0.0069
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.0338 0.1474 0.6844
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0176 0.0403
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0009 0.0014
Loa Loa (eye worm) hypothetical protein 0.0047 0.0139 0.0318
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0113 0.0125
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0198 0.0451
Onchocerca volvulus Peroxidase homolog 0.0038 0.0098 0.036
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0019 0.0009 0.0014
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0113 0.0384
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0009 0.0014
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0125 0.0495 0.0546
Loa Loa (eye worm) animal heme peroxidase 0.0038 0.0098 0.0221
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0057 0.0122
Loa Loa (eye worm) hypothetical protein 0.0038 0.0098 0.0221
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.0173 0.04
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0139 0.0559 0.2501
Schistosoma mansoni hypothetical protein 0.0172 0.0711 0.1678
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0113 0.0125
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0032 0.0134
Onchocerca volvulus 0.0042 0.0113 0.0448
Brugia malayi Animal haem peroxidase family protein 0.0038 0.0098 0.0211
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0012 0.0328
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0176 0.0403
Schistosoma mansoni zinc finger protein 0.0026 0.0042 0.0091
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0114 0.0105
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0111 0.0243
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0937 0.4223 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0042 0.0113 0.0258
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0038 0.0098 0.0221
Toxoplasma gondii hypothetical protein 0.0454 0.2007 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0113 0.0258
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0937 0.4223 1
Brugia malayi mbt repeat family protein 0.0055 0.0176 0.0396
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0937 0.4223 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0019 0.0036
Brugia malayi Blistered cuticle protein 3 0.0038 0.0098 0.0211
Echinococcus granulosus lysosomal alpha glucosidase 0.0189 0.0788 0.1855
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0032 0.0028
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0009 0.0014
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0056 0.0125
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0113 0.0254
Trichomonas vaginalis esterase, putative 0.0042 0.0113 0.0104
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.0173 0.7563
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0056 0.2306
Echinococcus granulosus polycomb protein SCMH1 0.0055 0.0176 0.0403
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0114 0.0105
Loa Loa (eye worm) hypothetical protein 0.0024 0.0032 0.0066
Loa Loa (eye worm) hypothetical protein 0.006 0.0198 0.046
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1543 0.1535
Chlamydia trachomatis sulfate transporter 0.0067 0.0228 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0032 0.0057
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0113 0.0255
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0057 0.0122
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0176 0.0403
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0114 0.0105
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0113 0.0125
Echinococcus granulosus carbonic anhydrase 0.0454 0.2007 0.4746
Schistosoma mansoni alpha-glucosidase 0.0162 0.0668 0.1574
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0056 0.0257
Echinococcus multilocularis lysosomal alpha glucosidase 0.0189 0.0788 0.1855
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0009 0.0009
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0114 0.0257
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.0714 0.0787
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0032 0.0134
Loa Loa (eye worm) hypothetical protein 0.0042 0.0113 0.0258
Schistosoma mansoni alpha-glucosidase 0.0162 0.0668 0.1574
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0454 0.2007 0.4743
Loa Loa (eye worm) hypothetical protein 0.0042 0.0113 0.0258
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0032 0.0028
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0113 0.0104
Plasmodium vivax glutathione reductase, putative 0.0055 0.0173 0.7563
Leishmania major hypothetical protein, conserved 0.0029 0.0056 0.0125
Loa Loa (eye worm) MBCTL1 0.0063 0.0211 0.0489
Trypanosoma brucei trypanothione reductase 0.0055 0.0173 0.0403
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0012 0.0013
Echinococcus granulosus zinc finger protein 0.0026 0.0042 0.0085
Schistosoma mansoni hypothetical protein 0.0024 0.0032 0.0067
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0033
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0686 0.3074 0.339
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0125 0.0495 0.0546
Mycobacterium ulcerans carbonic anhydrase 0.0338 0.1474 0.1471
Loa Loa (eye worm) hypothetical protein 0.0038 0.0098 0.0221
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.1543 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0032 0.0036
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0114 0.0251
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0222 0.0939 0.2214
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0012 0.0037
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0032 0.0028
Onchocerca volvulus 0.0055 0.0176 0.0791
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.0114 0.0105
Schistosoma mansoni ap endonuclease 0.002 0.0012 0.002
Schistosoma mansoni hypothetical protein 0.0019 0.0009 0.0015
Echinococcus multilocularis carbonic anhydrase II 0.0937 0.4223 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0013 0.0022
Loa Loa (eye worm) hypothetical protein 0.0454 0.2007 0.4748
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0454 0.2007 0.4743
Mycobacterium tuberculosis Probable oxidoreductase 0.0139 0.0559 0.0617
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0113 0.0125
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0013 0.0016
Onchocerca volvulus Peroxidasin homolog 0.0038 0.0098 0.036
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0006 0.0003
Schistosoma mansoni alpha glucosidase 0.0042 0.0114 0.0263
Brugia malayi hypothetical protein 0.0038 0.0098 0.0211
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.1543 1
Echinococcus granulosus dnaJ subfamily B 0.0474 0.2097 0.4957
Brugia malayi Bromodomain containing protein 0.0044 0.0126 0.0278
Toxoplasma gondii ABC1 family protein 0.0042 0.0113 0.0522
Onchocerca volvulus 0.0418 0.1842 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0113 0.0249
Schistosoma mansoni ap endonuclease 0.002 0.0012 0.002
Loa Loa (eye worm) hypothetical protein 0.0024 0.0032 0.0066
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.0176 0.0408
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0113 0.0125
Loa Loa (eye worm) hypothetical protein 0.0038 0.0098 0.0221
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0063 0.0211 0.0486
Loa Loa (eye worm) carbonic anhydrase 3 0.0937 0.4223 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0126 0.0288
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0937 0.4223 1
Schistosoma mansoni hypothetical protein 0.0454 0.2007 0.4749
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0012 0.002
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.0173 0.0397
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0113 0.0109
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0009 0.0014
Echinococcus granulosus carbonic anhydrase 0.0454 0.2007 0.4746
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0114 0.0263
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0114 0.0105
Schistosoma mansoni peroxidasin 0.0038 0.0098 0.0223
Echinococcus granulosus SAM and MBT domain containing protein 0.0055 0.0176 0.0403
Brugia malayi CXXC zinc finger family protein 0.0059 0.0193 0.0438
Echinococcus multilocularis carbonic anhydrase 0.0454 0.2007 0.4746
Echinococcus multilocularis carbonic anhydrase 0.0454 0.2007 0.4746
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0063 0.0211 0.0486
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0198 0.046
Brugia malayi PHD-finger family protein 0.0032 0.007 0.0146
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0222 0.0939 0.2214
Leishmania major trypanothione reductase 0.0055 0.0173 0.0403
Trypanosoma cruzi trypanothione reductase, putative 0.0019 0.0009 0.0014
Echinococcus multilocularis peroxidasin 0.0038 0.0098 0.0217
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0019 0.0009 0.001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0176 0.0403
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0012 0.0007
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0113 0.0255
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.0173 0.0397
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0019 0.0009 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0113 0.0261
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0937 0.4223 1
Brugia malayi hypothetical protein 0.0029 0.0056 0.0113
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0019 0.0009 0.0014
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0019 0.0009 0.0005
Brugia malayi Peroxidasin 0.0038 0.0098 0.0211
Plasmodium falciparum thioredoxin reductase 0.0019 0.0009 0.0023
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0937 0.4223 1
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0067 0.0228 0.0532
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0056 0.0235
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0125 0.0495 0.0546
Schistosoma mansoni carbonic anhydrase 0.0454 0.2007 0.4749
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0114 0.0105
Schistosoma mansoni hypothetical protein 0.0041 0.0111 0.0255
Loa Loa (eye worm) beta-lactamase 0.0042 0.0113 0.0258
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0454 0.2007 0.4743
Echinococcus granulosus carbonic anhydrase 0.0454 0.2007 0.4746
Loa Loa (eye worm) hypothetical protein 0.0038 0.0098 0.0221
Schistosoma mansoni myelin transcription factor 1 myt1 0.0063 0.0211 0.0491
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0937 0.4223 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0098 0.0221
Schistosoma mansoni carbonic anhydrase-related 0.0454 0.2007 0.4749
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0114 0.0105
Brugia malayi N-terminal motif family protein 0.0188 0.0785 0.1841
Schistosoma mansoni hypothetical protein 0.0474 0.2097 0.496
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0114 0.0105
Loa Loa (eye worm) mbt repeat family protein 0.0055 0.0176 0.0406
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0012 0.002
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0012 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0055 0.0176 0.0408
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0032 0.0069
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0012 0.0003
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.1991 0.9066 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0211 0.0489
Loa Loa (eye worm) hypothetical protein 0.0454 0.2007 0.4748
Loa Loa (eye worm) hypothetical protein 0.0042 0.0113 0.0258
Loa Loa (eye worm) hypothetical protein 0.0038 0.0098 0.0221
Mycobacterium leprae Probable transmembrane transport protein 0.0483 0.2139 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0056 0.0125
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0114 0.0257
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0009 0.0002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0113 0.0261
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1543 0.1535
Leishmania major carbonic anhydrase family protein, putative 0.0338 0.1474 0.3486
Echinococcus multilocularis histone acetyltransferase MYST2 0.0063 0.0211 0.0486
Brugia malayi Animal haem peroxidase family protein 0.0038 0.0098 0.0211
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0067 0.0228 0.0532
Schistosoma mansoni hypothetical protein 0.0019 0.0009 0.0015
Mycobacterium tuberculosis Probable reductase 0.0125 0.0495 0.0546
Onchocerca volvulus Putative sulfate transporter 0.0418 0.1842 1
Schistosoma mansoni hypothetical protein 0.0172 0.0711 0.1678
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.0714 0.3234
Plasmodium falciparum glutathione reductase 0.0055 0.0173 0.0843
Onchocerca volvulus Peroxidase homolog 0.0038 0.0098 0.036
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0009 0.0014
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0032 0.0057
Echinococcus multilocularis carbonic anhydrase 0.0454 0.2007 0.4746
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0019 0.0009 0.0014
Brugia malayi Bromodomain containing protein 0.009 0.0336 0.0777
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.0448 0.2196
Brugia malayi Glycosyl hydrolases family 31 protein 0.0189 0.0788 0.185
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0125 0.0495 0.2197
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0.0019 0.003
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0176 0.0406
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0067 0.0228 0.1094
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0032 0.0064
Loa Loa (eye worm) hypothetical protein 0.0188 0.0785 0.1849
Loa Loa (eye worm) animal heme peroxidase 0.0038 0.0098 0.0221
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0009 0.0014
Trypanosoma brucei glucosidase, putative 0.0042 0.0114 0.0263
Echinococcus multilocularis geminin 0.0172 0.0711 0.1673
Loa Loa (eye worm) glutathione reductase 0.0055 0.0173 0.04
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.0255 0.059
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0012 0.002
Echinococcus granulosus histone acetyltransferase MYST2 0.0063 0.0211 0.0486
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.0173 0.0191
Echinococcus granulosus cpg binding protein 0.0065 0.0219 0.0504
Brugia malayi mbt repeat family protein 0.0055 0.0176 0.0396
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1543 0.1535
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0032 0.0069
Schistosoma mansoni peroxidasin 0.0038 0.0098 0.0223
Mycobacterium ulcerans hypothetical protein 0.0024 0.0032 0.0028
Mycobacterium leprae Probable lipase LipE 0.0042 0.0113 0.0384
Toxoplasma gondii thioredoxin reductase 0.0055 0.0173 0.0822
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0019 0.0036
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0012 0.0014
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0067 0.0228 0.0223
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1543 0.1535
Onchocerca volvulus 0.0109 0.0423 0.2159
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0009 0.0002
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0019 0.0009 0.0014
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0012 0.0014
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0009 0.0001
Loa Loa (eye worm) blistered cuticle protein 3 0.0038 0.0098 0.0221
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0114 0.0263
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0012 0.0008
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0032 0.0134
Onchocerca volvulus Dual oxidase homolog 0.0038 0.0098 0.036
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0176 0.0397
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0113 0.0104
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0454 0.2007 0.4748
Schistosoma mansoni bromodomain containing protein 0.0077 0.0274 0.0641
Mycobacterium tuberculosis Conserved protein 0.0042 0.0113 0.0125
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0012 0.0018
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0198 0.0451
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0114 0.0263
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0009 0.0009
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.0176 0.0408
Onchocerca volvulus 0.0059 0.0193 0.0887
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1543 0.1535
Schistosoma mansoni carbonic anhydrase-related 0.0454 0.2007 0.4749
Loa Loa (eye worm) hypothetical protein 0.0055 0.0176 0.0406
Loa Loa (eye worm) hypothetical protein 0.0053 0.0164 0.0378
Trichomonas vaginalis conserved hypothetical protein 0.2195 1 1
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0483 0.2139 0.236
Brugia malayi Animal haem peroxidase family protein 0.0038 0.0098 0.0211
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0019 0.0009 0.0014
Leishmania major carbonic anhydrase-like protein 0.0937 0.4223 1
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0012 0.0003
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0019 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0042 0.0113 0.0258
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0056 0.0125
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0032 0.0028
Echinococcus granulosus GPCR family 2 0.0019 0.0009 0.0009
Loa Loa (eye worm) animal heme peroxidase 0.0038 0.0098 0.0221
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0012 0.0018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0176 0.0408
Echinococcus multilocularis SAM and MBT domain containing protein 0.0055 0.0176 0.0403
Echinococcus granulosus carbonic anhydrase II 0.0937 0.4223 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0454 0.2007 0.4743
Echinococcus multilocularis cpg binding protein 0.0065 0.0219 0.0504
Mycobacterium ulcerans beta-lactamase 0.0042 0.0113 0.0109
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0114 0.0526
Onchocerca volvulus 0.0042 0.0113 0.0448
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0113 0.4877
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0019 0.0009 0.0005
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.1543 1
Loa Loa (eye worm) animal heme peroxidase 0.0038 0.0098 0.0221
Echinococcus granulosus geminin 0.0172 0.0711 0.1673
Echinococcus multilocularis zinc finger protein 0.0026 0.0042 0.0085
Echinococcus multilocularis GPCR, family 2 0.0019 0.0009 0.0009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0012 0.002
Mycobacterium ulcerans integral membrane transporter 0.0067 0.0228 0.0223
Echinococcus granulosus peroxidasin 0.0038 0.0098 0.0217
Schistosoma mansoni carbonic anhydrase-related 0.0454 0.2007 0.4749
Brugia malayi Animal haem peroxidase family protein 0.0038 0.0098 0.0211
Loa Loa (eye worm) hypothetical protein 0.0024 0.0032 0.0066
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0019 0.0009 0.0023
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0113 0.0261
Schistosoma mansoni cpg binding protein 0.0059 0.0193 0.0449
Echinococcus multilocularis lysosomal alpha glucosidase 0.0189 0.0788 0.1855
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0009 0.0014
Loa Loa (eye worm) hypothetical protein 0.0038 0.0098 0.0221
Loa Loa (eye worm) hypothetical protein 0.0038 0.0098 0.0221
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0012 0.0017
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0056 0.0257
Schistosoma mansoni carbonic anhydrase 0.0338 0.1474 0.3486
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0019 0.0009 0.0206
Schistosoma mansoni hypothetical protein 0.0019 0.0009 0.0015
Loa Loa (eye worm) hypothetical protein 0.0038 0.0098 0.0221
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0266 0.1145 0.1263
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0.0019 0.003
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0114 0.026
Brugia malayi beta-lactamase 0.0042 0.0113 0.0249
Loa Loa (eye worm) hypothetical protein 0.0029 0.0056 0.0122
Echinococcus multilocularis dnaJ subfamily B 0.0474 0.2097 0.4957
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0032 0.0057
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0019 0.0009 0.0014
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0188 0.0785 0.4157
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0189 0.0788 0.1858
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0055 0.0176 0.0791
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0113 0.0104
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0032 0.0036
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0173 0.0403
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0009 0.0008
Mycobacterium tuberculosis Conserved protein 0.0042 0.0113 0.0125
Plasmodium falciparum carbonic anhydrase 0.0454 0.2007 1
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0067 0.0228 0.1115
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0013 0.0022
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0454 0.2007 0.4743
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0113 0.0261
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0032 0.0028
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0139 0.0559 0.0617
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0113 0.0125
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0063 0.0211 0.048
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0019 0.0009 0.0206
Schistosoma mansoni hypothetical protein 0.034 0.1482 0.3504
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0113 0.0104
Loa Loa (eye worm) hypothetical protein 0.0038 0.0098 0.0221
Brugia malayi beta-lactamase family protein 0.0042 0.0113 0.0249
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0176 0.0408
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0125 0.0495 0.0546
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0113 0.0261
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0019 0.0009 0.0014
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0067 0.0228 0.0223
Onchocerca volvulus Peroxidasin homolog 0.0038 0.0098 0.036
Mycobacterium ulcerans lipase LipD 0.0042 0.0113 0.0109
Onchocerca volvulus 0.0038 0.0098 0.036
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.0255 0.059
Onchocerca volvulus 0.0038 0.0098 0.036
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0113 0.0254
Loa Loa (eye worm) hypothetical protein 0.0038 0.0098 0.0221
Onchocerca volvulus 0.0038 0.0098 0.036
Onchocerca volvulus Chorion peroxidase homolog 0.0038 0.0098 0.036
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.0714 0.071
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0114 0.0669
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0009 0.0012
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1543 0.1535
Loa Loa (eye worm) hypothetical protein 0.0454 0.2007 0.4748
Loa Loa (eye worm) hypothetical protein 0.0041 0.0111 0.0252
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0016 0.0027
Entamoeba histolytica carbonic anhydrase, putative 0.0338 0.1474 0.9554
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0114 0.0105
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0032 0.0028
Brugia malayi beta-lactamase family protein 0.0042 0.0113 0.0249
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.1543 0.1535
Plasmodium vivax sulfate transporter, putative 0.0067 0.0228 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0019 0.0009 0.0005
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.1543 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0057 0.0128
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0012
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0113 0.0125
Mycobacterium tuberculosis Conserved protein 0.0042 0.0113 0.0125
Mycobacterium ulcerans hypothetical protein 0.0042 0.0113 0.0109
Loa Loa (eye worm) hypothetical protein 0.0082 0.0298 0.0696
Plasmodium falciparum thioredoxin reductase 0.0055 0.0173 0.0843
Brugia malayi glutathione reductase 0.0055 0.0173 0.0391
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0019 0.0009 0.0206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0176 0.0408
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0013 0.0016
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0113 0.0109
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0114 0.0669
Leishmania major hypothetical protein, conserved 0.0042 0.0113 0.0261
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0193 0.0447

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.6511 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 15.8114 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (binding) 25.1189 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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