Detailed information for compound 1242424

Basic information

Technical information
  • TDR Targets ID: 1242424
  • Name: 1-(3-chlorobenzoyl)-4-[1-[(3-chlorophenyl)met hoxy]-3-phenylpropan-2-yl]-1,4-diazepan-5-one
  • MW: 511.44 | Formula: C28H28Cl2N2O3
  • H donors: 0 H acceptors: 2 LogP: 5.21 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: Clc1cccc(c1)COCC(N1CCN(CCC1=O)C(=O)c1cccc(c1)Cl)Cc1ccccc1
  • InChi: 1S/C28H28Cl2N2O3/c29-24-10-4-8-22(16-24)19-35-20-26(17-21-6-2-1-3-7-21)32-15-14-31(13-12-27(32)33)28(34)23-9-5-11-25(30)18-23/h1-11,16,18,26H,12-15,17,19-20H2
  • InChiKey: QOXYFFIKINRZCW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(3-chlorobenzoyl)-4-[1-[(3-chlorophenyl)methoxymethyl]-2-phenyl-ethyl]-1,4-diazepan-5-one
  • 4-[1-[(3-chlorophenyl)methoxymethyl]-2-phenylethyl]-1-[(3-chlorophenyl)-oxomethyl]-1,4-diazepan-5-one
  • 4-[1-(benzyl)-2-(3-chlorobenzyl)oxy-ethyl]-1-(3-chlorobenzoyl)-1,4-diazepan-5-one
  • 1-(3-chlorophenyl)carbonyl-4-[1-[(3-chlorophenyl)methoxy]-3-phenyl-propan-2-yl]-1,4-diazepan-5-one
  • MLS000518538
  • SMR000128979
  • KUC100137

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.007 0.2548
Echinococcus granulosus nibrin 0.0011 0.0048 0.0076
Loa Loa (eye worm) hypothetical protein 0.0011 0.0048 0.0076
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0135 0.0354
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0019 0.0022
Leishmania major DNA polymerase kappa, putative 0.0019 0.0135 0.0354
Loa Loa (eye worm) hypothetical protein 0.0049 0.045 0.0819
Loa Loa (eye worm) hypothetical protein 0.0012 0.0051 0.0082
Loa Loa (eye worm) hypothetical protein 0.0011 0.0048 0.0076
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.5412
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0012 0.0034
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0019 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0065 0.0186
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.022 1
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0051 0.0044
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0131 0.0124
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0031 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0051 0.0082
Brugia malayi MH1 domain containing protein 0.001 0.0031 0.0045
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0135 0.0387
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.0713 0.1302
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0051 0.0082
Brugia malayi hypothetical protein 0.0011 0.0048 0.0076
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0012 0.0546
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0135 0.0236
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.054 0.0985
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0131 0.0124
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.007 0.2548
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.022 0.0601
Brugia malayi hypothetical protein 0.0446 0.4726 0.8708
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0019 0.0022
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0051 0.0044
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0051 0.0085
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.048 0.1381
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0.0048 0.0104
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0078 0.0136
Toxoplasma gondii histone lysine methyltransferase SET1 0.0112 0.1137 0.3249
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.0256
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0131 0.0229
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.0713 0.1302
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0012 0.0546
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.022 1
Echinococcus multilocularis smad 0.001 0.0031 0.0025
Echinococcus multilocularis nibrin 0.0011 0.0048 0.0041
Onchocerca volvulus 0.0033 0.0276 0.0561
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.022 0.0601
Loa Loa (eye worm) hypothetical protein 0.0016 0.0095 0.0162
Schistosoma mansoni dishevelled 0.0009 0.0019 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0065 0.0186
Echinococcus granulosus survival motor neuron protein 1 0.0511 0.5426 1
Brugia malayi topoisomerase 0.0011 0.0048 0.0076
Onchocerca volvulus 0.0012 0.0051 0.0083
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.048 0.1381
Echinococcus granulosus intermediate filament protein 0.0033 0.0276 0.0497
Loa Loa (eye worm) hypothetical protein 0.0019 0.0131 0.0229
Brugia malayi TAR-binding protein 0.0073 0.0713 0.1302
Trypanosoma brucei unspecified product 0.0013 0.007 0.2548
Echinococcus multilocularis geminin 0.0367 0.3876 0.3872
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0065 0.0186
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0019 0.0012
Brugia malayi steroid hormone receptor 0.0012 0.0051 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.007 0.2548
Loa Loa (eye worm) hypothetical protein 0.0012 0.0051 0.0082
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0012 0.0546
Mycobacterium ulcerans hypothetical protein 0.0027 0.022 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0051 0.0082
Loa Loa (eye worm) Smad1 0.001 0.0031 0.0045
Trichomonas vaginalis replication factor C large subunit, putative 0.0011 0.0048 0.0137
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0131 0.0344
Loa Loa (eye worm) hypothetical protein 0.0012 0.0051 0.0082
Loa Loa (eye worm) hypothetical protein 0.0114 0.1149 0.2107
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.022 1
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0012 0.001
Echinococcus multilocularis Niemann Pick C1 protein 0.0162 0.1674 0.1668
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0051 0.0044
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0051 0.0085
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0511 0.093
Echinococcus granulosus expressed conserved protein 0.0107 0.1075 0.197
Echinococcus multilocularis lamin 0.0033 0.0276 0.027
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.022 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.027 0.0485
Schistosoma mansoni hypothetical protein 0.0367 0.3876 0.7385
Loa Loa (eye worm) hypothetical protein 0.0009 0.0019 0.0022
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0051 0.0085
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0051 0.0083
Toxoplasma gondii hypothetical protein 0.0009 0.0019 0.002
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0051 0.0085
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.048 0.0873
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0146 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0019 0.0022
Schistosoma mansoni cpg binding protein 0.006 0.0575 0.1086
Brugia malayi MH2 domain containing protein 0.001 0.0031 0.0045
Loa Loa (eye worm) hypothetical protein 0.0012 0.0051 0.0082
Loa Loa (eye worm) hypothetical protein 0.0019 0.0135 0.0236
Echinococcus granulosus dna polymerase eta 0.0019 0.0135 0.0236
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0012 0.001
Loa Loa (eye worm) macrophage migration inhibitory factor 0.0329 0.3474 0.6397
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0048 0.1581
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0051 0.0082
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0051 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.5412
Loa Loa (eye worm) hypothetical protein 0.0012 0.0051 0.0082
Loa Loa (eye worm) hypothetical protein 0.0446 0.4726 0.8708
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0019 0.0022
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.0048 0.0078
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0051 0.0082
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0012 0.001
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0019 0.0012
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.022 0.0601
Echinococcus multilocularis musashi 0.0033 0.0276 0.027
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0369 0.0668
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0051 0.0085
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0019 0.0022
Brugia malayi hypothetical protein 0.0019 0.0128 0.0223
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0146 0.6617
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0065 0.0186
Echinococcus granulosus geminin 0.0367 0.3876 0.7139
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0012 0.0546
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0019 0.0022
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0176 0.1823 0.3842
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0048 0.0137
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0011 0.0048 0.0076
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0135 0.6121
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0051 0.0082
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0135 0.5412
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0135 0.5412
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.0329 0.3474 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0051 0.0085
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0135 0.0244
Schistosoma mansoni hypothetical protein 0.0019 0.0131 0.0237
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0048 0.0137
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0511 0.0963
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0031 0.0045
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0014 0.0013
Onchocerca volvulus 0.0009 0.0019 0.0015
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.0256
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0116 0.0201
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0031 0.0025
Echinococcus multilocularis dna polymerase eta 0.0019 0.0135 0.0128
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0134 0.6071
Schistosoma mansoni DNA ligase IV 0.0011 0.0048 0.0078
Schistosoma mansoni lamin 0.0033 0.0276 0.0514
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.045 0.0444
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0131 0.0229
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.123 0.2334
Echinococcus granulosus Protein patched homolog 1 0.0049 0.045 0.0819
Loa Loa (eye worm) runx1 0.0056 0.0528 0.0961
Loa Loa (eye worm) hypothetical protein 0.0176 0.1823 0.3352
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.5412
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0135 0.5412
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0066 0.0109
Schistosoma mansoni hypothetical protein 0.0367 0.3876 0.7385
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0051 0.0082
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0131 0.525
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.0256
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0141 0.1439 0.2643
Onchocerca volvulus 0.0033 0.0276 0.0561
Schistosoma mansoni hypothetical protein 0.0047 0.0432 0.0811
Brugia malayi CHE-14 protein 0.0049 0.045 0.0819
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0135 0.0354
Echinococcus granulosus Niemann Pick C1 protein 0.0114 0.1149 0.2107
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0131 0.0229
Loa Loa (eye worm) hypothetical protein 0.0027 0.022 0.0394
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.048 0.1352
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0048 0.0137
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0051 0.0082
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0511 0.0505
Brugia malayi MH2 domain containing protein 0.0144 0.1478 0.2715
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0434 0.1126
Brugia malayi ecdysteroid receptor 0.0012 0.0051 0.0082
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0051 0.0085
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0065 0.0186
Brugia malayi intermediate filament protein 0.0033 0.0276 0.0497
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0135 0.0128
Brugia malayi AMP-binding enzyme family protein 0.0027 0.022 0.0394
Brugia malayi isocitrate dehydrogenase 0.0019 0.0131 0.0229
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0135 0.0128
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0019 0.0023
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0113 0.0197
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0574 0.1046
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0012 0.001
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0116 0.0109
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0051 0.0082
Brugia malayi nuclear receptor NHR-88 0.0012 0.0051 0.0082
Schistosoma mansoni topbp1 0.0011 0.0048 0.0078
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0713 0.1347
Entamoeba histolytica hypothetical protein 0.0011 0.0048 0.0104
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0135 0.0236
Echinococcus multilocularis expressed conserved protein 0.0107 0.1075 0.1068
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0135 0.0236
Onchocerca volvulus 0.0057 0.054 0.1121
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0131 0.525
Loa Loa (eye worm) hypothetical protein 0.006 0.0569 0.1037
Brugia malayi hypothetical protein 0.0009 0.0019 0.0022
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0051 0.0082
Echinococcus multilocularis survival motor neuron protein 1 0.0511 0.5426 0.5423
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0051 0.0044
Echinococcus multilocularis protein dispatched 1 0.0056 0.0525 0.0518
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.001
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0131 0.5953
Schistosoma mansoni survival motor neuron protein 0.0104 0.1048 0.1987
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0065 0.0186
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0146 0.6421
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0065 0.0186
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0048 0.0137
Onchocerca volvulus 0.0011 0.0048 0.0076
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.048 0.1352
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1478 0.2715
Loa Loa (eye worm) hypothetical protein 0.0011 0.0048 0.0076
Loa Loa (eye worm) TAR-binding protein 0.0073 0.0713 0.1302
Loa Loa (eye worm) hypothetical protein 0.0012 0.0051 0.0082
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0065 0.0186
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0135 0.5896
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0078 0.0132
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0019 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0051 0.0082
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.048 0.1352
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0012 0.0546
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0131 0.0229
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0574 0.1046
Echinococcus multilocularis protein patched 0.0049 0.045 0.0444
Schistosoma mansoni hypothetical protein 0.0047 0.0432 0.0811
Trypanosoma brucei unspecified product 0.0019 0.0135 0.5412
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0065 0.0186
Trypanosoma cruzi FHA domain containing protein, putative 0.0011 0.0048 0.1581
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0048 0.0137
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0051 0.0044
Loa Loa (eye worm) oxidoreductase 0.0008 0.0012 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0065 0.0186
Brugia malayi Smad1 0.001 0.0031 0.0045
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0065 0.0186
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0574 0.1046
Brugia malayi Pax transcription activation domain interacting protein 0.0011 0.0048 0.0076
Echinococcus granulosus lamin 0.0033 0.0276 0.0497
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0065 0.0186
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0051 0.0082
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0051 0.0085
Toxoplasma gondii ATPase, AAA family protein 0.0011 0.0048 0.0104
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0713 0.1347
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0239 0.0655
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0012 0.0546
Loa Loa (eye worm) hypothetical protein 0.0029 0.0239 0.0428
Schistosoma mansoni hypothetical protein 0.0494 0.5245 1
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0048 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0051 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.5412
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0135 0.0387
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.022 0.0601
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0239 0.0655
Brugia malayi DKFZp564C0469 protein 0.0011 0.0048 0.0076
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0012 0.001
Giardia lamblia Macrophage migration inhibitory factor 0.0329 0.3474 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.022 0.0601
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0048 0.0137
Brugia malayi AMP-binding enzyme family protein 0.0027 0.022 0.0394
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0051 0.0082
Schistosoma mansoni hypothetical protein 0.0047 0.0432 0.0811
Echinococcus multilocularis cpg binding protein 0.006 0.0575 0.0569
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0051 0.0082
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0011 0.0048 0.1722
Brugia malayi MH2 domain containing protein 0.001 0.0031 0.0045
Brugia malayi N-terminal motif family protein 0.0176 0.1823 0.3352
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0141 0.1439 0.2643
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.045 0.0819
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0051 0.0082
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0511 0.0505
Leishmania major macrophage migration inhibitory factor-like protein 0.0329 0.3474 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0051 0.0082
Loa Loa (eye worm) hypothetical protein 0.0027 0.022 0.0394
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0131 0.0124
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0051 0.0082
Schistosoma mansoni cpg binding protein 0.0057 0.054 0.1019
Loa Loa (eye worm) hypothetical protein 0.0011 0.0048 0.0076
Schistosoma mansoni intermediate filament proteins 0.0033 0.0276 0.0514
Echinococcus granulosus Smad4 0.001 0.0031 0.0045
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0131 0.0344
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0048 0.1581
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0276 0.0497
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.5412
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.1811 0.3328
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0511 0.0963
Brugia malayi hypothetical protein 0.0029 0.0239 0.0428
Loa Loa (eye worm) hypothetical protein 0.0012 0.0051 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.045 0.1296
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0051 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0051 0.0082
Schistosoma mansoni lozenge 0.0056 0.0528 0.0994
Brugia malayi RNA binding protein 0.0073 0.0713 0.1302
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0051 0.0085
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0012 0.0546
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0146 0.0386
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0114 0.1149 0.3284
Echinococcus multilocularis Smad4 0.001 0.0031 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0051 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.5412
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0131 0.0344
Brugia malayi Bm-MIF-1, identical 0.0329 0.3474 0.6397
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0065 0.0186
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0115 0.1168 0.2216
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0131 0.0124
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0434 0.1218
Schistosoma mansoni smad 0.001 0.0031 0.0047
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0011 0.0048 0.1722
Schistosoma mansoni coup transcription factor 0.0012 0.0051 0.0085
Leishmania major DNA polymerase eta, putative 0.0019 0.0135 0.0354
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0051 0.0083
Schistosoma mansoni cpg binding protein 0.006 0.0575 0.1086
Brugia malayi hypothetical protein 0.0011 0.0048 0.0076
Loa Loa (eye worm) hypothetical protein 0.0011 0.0048 0.0076
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0051 0.0085
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0511 0.093
Trichomonas vaginalis helicase, putative 0.0013 0.0065 0.0186
Schistosoma mansoni dishevelled 0.0009 0.0019 0.0023
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.022 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0131 0.0229
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.022 1
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0131 0.0344
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0065 0.0186
Echinococcus multilocularis GPCR, family 2 0.0019 0.0131 0.0124
Brugia malayi hypothetical protein 0.0009 0.0019 0.0022
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0078 0.0072
Loa Loa (eye worm) hypothetical protein 0.0009 0.0019 0.0022
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0019 0.0022
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0051 0.0044
Schistosoma mansoni smad1 5 8 and 0.001 0.0031 0.0047
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0131 0.525
Schistosoma mansoni DNA polymerase eta 0.0019 0.0135 0.0244
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.1811 0.3443
Loa Loa (eye worm) acetyltransferase 0.0175 0.1811 0.3328
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0131 0.0229
Plasmodium vivax replication factor C subunit 1, putative 0.0011 0.0048 0.0104
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0012 0.001
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0239 1
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0012 0.0546
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0051 0.0082
Loa Loa (eye worm) hypothetical protein 0.0027 0.022 0.0394
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0065 0.0186
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.5412
Schistosoma mansoni dep domain containing protein 0.0009 0.0019 0.0023
Brugia malayi AMP-binding enzyme family protein 0.0027 0.022 0.0394
Trichomonas vaginalis conserved hypothetical protein 0.0329 0.3474 1
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0019 0.0015
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0031 0.0047
Schistosoma mansoni hypothetical protein 0.0019 0.0131 0.0237
Brugia malayi nuclear hormone receptor 0.0012 0.0051 0.0082
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.045 0.0819
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0131 0.0344
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0134 0.6071
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0019 0.0022
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0135 0.6121
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0135 0.5412
Schistosoma mansoni hypothetical protein 0.0047 0.0432 0.0811
Treponema pallidum DNA ligase (lig) 0.0011 0.0048 0.5
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0135 0.5896
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0011 0.0048 0.0104
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0012 0.0546
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0713 0.1347
Onchocerca volvulus 0.0446 0.4726 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0051 0.0082
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0135 0.5412
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0019 0.0022
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0054 0.0511 0.093
Echinococcus granulosus tar DNA binding protein 0.0073 0.0713 0.1302
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0078 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0051 0.0082
Loa Loa (eye worm) hypothetical protein 0.006 0.0574 0.1046
Schistosoma mansoni patched 1 0.0049 0.045 0.0847
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.022 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0135 0.5412
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0051 0.0082
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0131 0.0124
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0051 0.0082
Schistosoma mansoni smad1 5 8 and 0.001 0.0031 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0051 0.0082
Loa Loa (eye worm) hypothetical protein 0.0446 0.4726 0.8708
Schistosoma mansoni Smad4 0.001 0.0031 0.0047
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0051 0.0082
Loa Loa (eye worm) hypothetical protein 0.0008 0.0012 0.001
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0012 0.0034
Echinococcus granulosus GPCR family 2 0.0019 0.0131 0.0229
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0019 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0048 0.0137
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0511 0.0963
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0131 0.0229
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0051 0.0082
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0134 0.6071
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.1811 0.1805
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.1758 0.3231
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0146 0.0386
Echinococcus multilocularis Protein lozenge 0.0056 0.0528 0.0521
Plasmodium vivax macrophage migration inhibitory factor, putative 0.0329 0.3474 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.0256
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0054 0.0511 0.093
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0134 0.6071
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0116 0.0201
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0434 0.1218
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0135 0.5412
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0239 0.0655
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0131 0.0124
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0135 0.5412
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0078 0.0132
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0065 0.0186
Echinococcus granulosus smad 0.001 0.0031 0.0045
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0135 0.0236
Leishmania major hypothetical protein, conserved 0.0029 0.0239 0.0655
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0051 0.0083
Plasmodium falciparum macrophage migration inhibitory factor 0.0329 0.3474 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0051 0.0085
Schistosoma mansoni hypothetical protein 0.0013 0.0066 0.0113
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0051 0.0082
Loa Loa (eye worm) hypothetical protein 0.0041 0.0369 0.0668
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0131 0.0229
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0066 0.0059
Giardia lamblia DINP protein human, muc B family 0.0019 0.0135 0.0254
Brugia malayi hypothetical protein 0.0511 0.5426 1
Brugia malayi MH1 domain containing protein 0.001 0.0031 0.0045
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0113 0.0197
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0048 0.0137
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1478 0.2715
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0051 0.0044
Schistosoma mansoni hypothetical protein 0.0104 0.1048 0.1987
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.5412
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0019 0.0012
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0048 0.1581
Plasmodium falciparum replication factor C subunit 1, putative 0.0011 0.0048 0.0104
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0051 0.0085
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.0329 0.3474 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0276 0.0497
Schistosoma mansoni lamin 0.0033 0.0276 0.0514
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0012 0.001
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.022 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0012 0.0005
Leishmania major macrophage migration inhibitory factor-like protein 0.0329 0.3474 1
Loa Loa (eye worm) RNA binding protein 0.0073 0.0713 0.1302
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0012 0.0546
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0239 0.0655
Schistosoma mansoni hypothetical protein 0.0019 0.0131 0.0237
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.5412
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0104 0.1048 0.192
Echinococcus multilocularis lamin dm0 0.0033 0.0276 0.027
Loa Loa (eye worm) hypothetical protein 0.0015 0.0088 0.0151
Onchocerca volvulus 0.0104 0.1048 0.2197
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0048 0.0041
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0019 0.0012
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0131 0.525
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0048 0.0137
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.022 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0012 0.0546
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0031 0.0045
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0131 0.0124
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.022 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.022 0.0601
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0135 0.5412
Echinococcus granulosus Niemann Pick C1 protein 0.0162 0.1674 0.3076
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0065 0.0186
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0012 0.001
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0051 0.0082
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0095 0.0162
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0019 0.0023
Echinococcus multilocularis tar DNA binding protein 0.0073 0.0713 0.0706
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0131 0.0237
Schistosoma mansoni smad1 5 8 and 0.001 0.0031 0.0047
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0276 0.0497
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0713 0.1347
Brugia malayi DIX domain containing protein 0.0009 0.0019 0.0022
Echinococcus granulosus dnaJ subfamily B 0.0494 0.5245 0.9666
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0095 0.0088
Echinococcus granulosus dna polymerase kappa 0.0019 0.0135 0.0236
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0011 0.0048 0.5
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0048 0.1581
Loa Loa (eye worm) hypothetical protein 0.0511 0.5426 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0051 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0051 0.0082
Schistosoma mansoni topbp1 0.0011 0.0048 0.0078
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0012 0.001
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0019 0.0022
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0051 0.0082
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0012 0.001
Loa Loa (eye worm) hypothetical protein 0.0015 0.0088 0.0151
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0031 0.0045
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.0329 0.3474 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0048 0.0076
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0239 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0114 0.1149 0.1143
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0135 0.0244
Schistosoma mansoni hypothetical protein 0.0041 0.0369 0.0691
Schistosoma mansoni hypothetical protein 0.0019 0.0131 0.0237
Onchocerca volvulus 0.0027 0.022 0.0441
Echinococcus granulosus cpg binding protein 0.006 0.0575 0.1049
Loa Loa (eye worm) hypothetical protein 0.002 0.0146 0.0256
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0239 1
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.5245 0.5242
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0276 0.0497
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.022 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0031 0.0025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0051 0.0082
Brugia malayi CXXC zinc finger family protein 0.0057 0.054 0.0985
Trypanosoma brucei unspecified product 0.0013 0.007 0.2548
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0135 0.5412
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0713 0.1347
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0113 0.0197
Echinococcus granulosus lamin dm0 0.0033 0.0276 0.0497
Brugia malayi Niemann-Pick C1 protein precursor 0.0114 0.1149 0.2107

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.581 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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