Detailed information for compound 1250437

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 512.615 | Formula: C27H30F2N4O2S
  • H donors: 2 H acceptors: 2 LogP: 4.88 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCC(=O)N1N=C(SC21C1CCCC2C(NC1c1cccc(c1)F)c1cccc(c1)F)NC(=O)CC
  • InChi: 1S/C27H30F2N4O2S/c1-3-22(34)30-26-32-33(23(35)4-2)27(36-26)20-12-7-13-21(27)25(17-9-6-11-19(29)15-17)31-24(20)16-8-5-10-18(28)14-16/h5-6,8-11,14-15,20-21,24-25,31H,3-4,7,12-13H2,1-2H3,(H,30,32,34)
  • InChiKey: COGCAQSJZCZVFV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0074 0.0702 0.1783
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0067 0.0277
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0067 0.0137
Loa Loa (eye worm) hypothetical protein 0.0033 0.0231 0.0527
Schistosoma mansoni methionine-tRNA synthetase 0.0022 0.0112 0.0105
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0284 0.3076 0.4014
Mycobacterium tuberculosis Conserved protein 0.0074 0.0702 0.1207
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0284 0.3076 0.4014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0655 0.9281
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0655 0.9281
Loa Loa (eye worm) hypothetical protein 0.0022 0.0112 0.0212
Loa Loa (eye worm) hypothetical protein 0.0042 0.0337 0.0812
Loa Loa (eye worm) hypothetical protein 0.0074 0.0702 0.1783
Brugia malayi hypothetical protein 0.0049 0.0419 0.1107
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0064 0.0586 0.8222
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0284 0.3076 0.8101
Onchocerca volvulus 0.0042 0.0338 0.1186
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0067 0.0046
Brugia malayi Pre-SET motif family protein 0.003 0.0199 0.0525
Leishmania major cathepsin L-like protease 0.0018 0.0067 0.0277
Echinococcus multilocularis methionine tRNA synthetase 0.0059 0.0524 0.0493
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0419 0.7705
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0067 0.0277
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0077 0.012
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0067 0.0137
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0075 0.0171
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0067 0.0134
Onchocerca volvulus Huntingtin homolog 0.0131 0.1342 0.5085
Brugia malayi Dopamine receptor protein 2 0.0015 0.0032 0.0086
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0077 0.0045
Loa Loa (eye worm) CHromoDomain protein family member 0.0016 0.004 0.0021
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.0346 0.3789 0.4954
Brugia malayi Cathepsin L-like precursor 0.0018 0.0067 0.0177
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0655 0.9281
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0067 0.0134
Brugia malayi G-protein coupled receptor 0.0015 0.0032 0.0086
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0655 0.9281
Brugia malayi Cathepsin L-like precursor 0.0018 0.0067 0.0177
Onchocerca volvulus 0.0018 0.0067 0.0134
Schistosoma mansoni hypothetical protein 0.0437 0.4812 0.6303
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.032 0.4141
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0077 0.0204
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0476 0.5256 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.032 0.3974
Brugia malayi GnHR receptor homolog 0.0015 0.0032 0.0086
Brugia malayi neuropeptide F receptor 0.0015 0.0032 0.0086
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0154 0.1603 0.4231
Brugia malayi G protein-coupled receptor F59B2.13 0.0015 0.0032 0.0086
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0071 0.0051
Brugia malayi TAR-binding protein 0.007 0.065 0.1715
Loa Loa (eye worm) fibroinase 0.0018 0.0067 0.0092
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0702 0.1854
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0059 0.0524 0.7273
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0022 0.0112 0.008
Brugia malayi RE15519p 0.0015 0.0032 0.0086
Onchocerca volvulus 0.0234 0.2513 0.9637
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.054 0.067
Brugia malayi Bromodomain containing protein 0.0084 0.0815 0.2152
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0199 0.2076
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0075 0.0171
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0067 0.0137
Trichomonas vaginalis chromobox protein, putative 0.0075 0.0706 0.2715
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0159 0.0167
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.054 0.0894
Echinococcus granulosus chromobox protein 1 0.0075 0.0706 0.0889
Schistosoma mansoni zinc finger protein 0.0017 0.0049 0.0022
Brugia malayi Tachykinin-like peptides receptor 99D 0.0015 0.0032 0.0086
Echinococcus multilocularis zinc finger protein 0.0023 0.0122 0.009
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.032 0.1155
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.041 0.0379
Brugia malayi Cathepsin L-like precursor 0.0018 0.0067 0.0177
Loa Loa (eye worm) hypothetical protein 0.0074 0.0702 0.1783
Leishmania major cathepsin L-like protease 0.0018 0.0067 0.0277
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.054 0.7446
Plasmodium vivax SET domain protein, putative 0.003 0.0199 0.2076
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.032 0.4141
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0702 0.1207
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.054 0.7517
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0015 0.0032 0.0086
Brugia malayi hypothetical protein 0.0015 0.0032 0.0086
Loa Loa (eye worm) hypothetical protein 0.0042 0.0333 0.0801
Echinococcus granulosus methionine tRNA synthetase 0.0059 0.0524 0.0649
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0067 0.0137
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0702 0.2699
Onchocerca volvulus 0.0033 0.0231 0.077
Brugia malayi chromobox protein homolog 3 0.0042 0.0333 0.088
Schistosoma mansoni hypothetical protein 0.0331 0.361 0.4718
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0059 0.0524 0.7149
Echinococcus granulosus zinc finger protein 0.0023 0.0122 0.0118
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.026 0.03
Loa Loa (eye worm) pax transcription factor protein 2 0.0242 0.2607 0.6852
Loa Loa (eye worm) hypothetical protein 0.0074 0.0702 0.1783
Brugia malayi methionyl-tRNA synthetase 0.0022 0.0112 0.0296
Onchocerca volvulus 0.0242 0.2607 1
Plasmodium falciparum methionine--tRNA ligase, putative 0.0022 0.0112 0.0986
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0702 0.0884
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0016 0.004 0.001
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.054 0.0509
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0608 0.0759
Schistosoma mansoni leucyl-tRNA synthetase 0.0022 0.0112 0.0105
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0419 0.5668
Echinococcus multilocularis GPCR, family 2 0.0049 0.041 0.0379
Brugia malayi methionyl-tRNA synthetase 0.0059 0.0524 0.1383
Loa Loa (eye worm) tyrosyl-tRNA synthetase 0.0036 0.027 0.0632
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0067 0.0137
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0307 0.0275
Schistosoma mansoni hypothetical protein 0.0022 0.011 0.0102
Schistosoma mansoni tar DNA-binding protein 0.007 0.065 0.0814
Brugia malayi sulfakinin receptor protein 0.0015 0.0032 0.0086
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0079 0.0123
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0655 0.9281
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0199 0.0219
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0071 0.0051
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.041 0.1082
Schistosoma mansoni bromodomain containing protein 0.0071 0.0669 0.0839
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0059 0.0524 0.5869
Echinococcus multilocularis cpg binding protein 0.0035 0.0249 0.0217
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0199 0.0167
Brugia malayi hypothetical protein 0.0015 0.0032 0.0086
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.041 0.0379
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0071 0.0039
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0016 0.004 0.0008
Leishmania major cathepsin L-like protease 0.0018 0.0067 0.0277
Brugia malayi follicle stimulating hormone receptor 0.0015 0.0032 0.0086
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.026 0.0228
Loa Loa (eye worm) beta-lactamase 0.0074 0.0702 0.1783
Brugia malayi G-protein coupled receptor 0.0015 0.0032 0.0086
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.041 0.0498
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0702 1
Echinococcus granulosus cathepsin l1 0.0018 0.0067 0.0046
Loa Loa (eye worm) hypothetical protein 0.0074 0.0702 0.1783
Loa Loa (eye worm) heterochromatin protein 1 0.0075 0.0706 0.1794
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0067 0.0035
Loa Loa (eye worm) hypothetical protein 0.0154 0.1603 0.4182
Loa Loa (eye worm) hypothetical protein 0.0346 0.3789 1
Schistosoma mansoni zinc finger protein 0.0023 0.0122 0.0118
Schistosoma mansoni hypothetical protein 0.0017 0.0049 0.0022
Trypanosoma cruzi cruzipain precursor, putative 0.007 0.0655 0.9281
Schistosoma mansoni hypothetical protein 0.0023 0.0116 0.011
Brugia malayi beta-lactamase family protein 0.0074 0.0702 0.1854
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0284 0.3076 0.4014
Brugia malayi RNA binding protein 0.007 0.065 0.1715
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0075 0.0171
Loa Loa (eye worm) TAR-binding protein 0.007 0.065 0.1643
Brugia malayi Inositol-1 0.0041 0.032 0.0843
Brugia malayi hypothetical protein 0.0131 0.1342 0.354
Mycobacterium ulcerans lipase LipD 0.0074 0.0702 1
Mycobacterium ulcerans beta-lactamase 0.0074 0.0702 1
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0067 0.0046
Schistosoma mansoni hypothetical protein 0.0049 0.041 0.0498
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0067 0.0137
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0016 0.004 0.001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0077 0.0436
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0655 0.9281
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0271 0.0374
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.011 0.0102
Treponema pallidum leucyl-tRNA synthetase 0.0022 0.0112 1
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0702 0.1207
Schistosoma mansoni ap endonuclease 0.0019 0.0077 0.0059
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.1051 0.2774
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0702 0.1207
Brugia malayi Latrophilin receptor protein 2 0.0049 0.041 0.1082
Brugia malayi hypothetical protein 0.0015 0.0032 0.0086
Echinococcus granulosus cpg binding protein 0.0035 0.0249 0.0286
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.054 0.7404
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0702 1
Schistosoma mansoni ap endonuclease 0.0019 0.0077 0.0059
Trichomonas vaginalis chromobox protein, putative 0.0075 0.0706 0.2715
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0655 0.9281
Onchocerca volvulus 0.0031 0.0205 0.0672
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0077 0.0059
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0067 0.0137
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0059 0.0524 0.0863
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0067 0.0046
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0067 0.0137
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0077 0.0179
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0067 0.0137
Brugia malayi hypothetical protein 0.0015 0.0032 0.0086
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.054 0.067
Echinococcus granulosus chromobox protein 1 0.0075 0.0706 0.0889
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0702 0.1207
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0702 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0077 0.0436
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0412 0.0501
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0702 0.1207
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0067 0.0137
Brugia malayi putative neuropeptide receptor 0.0015 0.0032 0.0086
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0059 0.0524 1
Schistosoma mansoni tar DNA-binding protein 0.007 0.065 0.0814
Brugia malayi Serotonin receptor 0.0015 0.0032 0.0086
Schistosoma mansoni methionine-tRNA synthetase 0.0059 0.0524 0.0649
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0067 0.0092
Loa Loa (eye worm) hypothetical protein 0.0022 0.0112 0.0212
Brugia malayi ORL1-like opioid receptor 0.0015 0.0032 0.0086
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0059 0.0524 0.7273
Plasmodium vivax methionine--tRNA ligase, putative 0.0059 0.0524 0.7196
Brugia malayi hypothetical protein 0.0015 0.0032 0.0086
Trichomonas vaginalis set domain proteins, putative 0.0234 0.2513 1
Onchocerca volvulus 0.0018 0.0067 0.0134
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.2192 0.5748
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0015 0.0032 0.0086
Brugia malayi hypothetical protein 0.0015 0.0032 0.0086
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0067 0.0137
Toxoplasma gondii methionyl-tRNA synthetase 0.0059 0.0524 0.7196
Giardia lamblia Methionyl-tRNA synthetase 0.0059 0.0524 1
Brugia malayi CHD4 protein 0.0016 0.004 0.0106
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0307 0.0362
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0419 0.5668
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.065 0.1643
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0179 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0194 0.0651
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0039 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0067 0.0137
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0412 0.0501
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0702 0.2699
Echinococcus multilocularis cysteine protease 0.0018 0.0067 0.0035
Brugia malayi hypothetical protein 0.0015 0.0032 0.0086
Echinococcus multilocularis dnaJ subfamily B 0.0437 0.4812 0.4796
Brugia malayi Bromodomain containing protein 0.0042 0.0337 0.0888
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0015 0.0032 0.0086
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0075 0.0171
Schistosoma mansoni cpg binding protein 0.0035 0.0249 0.0286
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0077 0.0227
Schistosoma mansoni hypothetical protein 0.0331 0.361 0.4718
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0559 0.7735
Loa Loa (eye worm) RNA binding protein 0.007 0.065 0.1643
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.032 0.1155
Leishmania major cathepsin L-like protease 0.0018 0.0067 0.0277
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0419 0.5545
Entamoeba histolytica hypothetical protein 0.0035 0.026 0.7634
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0077 0.0164
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0022 0.0112 0.0776
Loa Loa (eye worm) hypothetical protein 0.0049 0.0411 0.1007
Brugia malayi protein ZK524.3 0.0022 0.0112 0.0296
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0655 0.9281
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0067 0.0035
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.032 0.1155
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0702 0.0884
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.0346 0.3789 0.3769
Schistosoma mansoni hypothetical protein 0.0105 0.1051 0.1343
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0159 0.0127
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0159 0.0167
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0075 0.0171
Treponema pallidum methionyl-tRNA synthetase 0.0022 0.0112 1
Brugia malayi Pax transcription factor protein 2 0.0242 0.2607 0.6879
Echinococcus granulosus tar DNA binding protein 0.007 0.065 0.0814
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0059 0.0524 0.198
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.032 0.3874
Echinococcus multilocularis microtubule associated protein 2 0.0683 0.7616 0.7608
Echinococcus multilocularis chromobox protein 1 0.0075 0.0706 0.0676
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0067 0.0137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0067 0.0137
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0419 0.7705
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.041 0.1005
Echinococcus multilocularis tar DNA binding protein 0.007 0.065 0.0619
Brugia malayi putative neuropeptide receptor NPR1 0.0015 0.0032 0.0086
Leishmania major cathepsin L-like protease 0.007 0.0655 0.9281
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0702 0.2699
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0039 0.0023
Onchocerca volvulus 0.0018 0.0067 0.0134
Schistosoma mansoni chromobox protein 0.0075 0.0706 0.0889
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.032 0.0288
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.011 0.0077
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0655 0.9281
Brugia malayi hypothetical protein 0.0032 0.022 0.0581
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0194 0.0651
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0284 0.3076 0.3054
Brugia malayi RNA recognition motif domain containing protein 0.007 0.065 0.1715
Mycobacterium tuberculosis Conserved protein 0.0074 0.0702 0.1207
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.0624 0.078
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0067 0.0177
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0205 0.046
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.032 0.5419
Entamoeba histolytica hypothetical protein 0.0035 0.026 0.7634
Brugia malayi Cathepsin L-like precursor 0.0018 0.0067 0.0177
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.054 0.7404
Trichomonas vaginalis chromobox protein, putative 0.0045 0.037 0.1357
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0077 0.0412
Brugia malayi SET domain containing protein 0.0014 0.0016 0.0043
Schistosoma mansoni hypothetical protein 0.0049 0.041 0.0498
Echinococcus granulosus GPCR family 2 0.0049 0.041 0.0498
Brugia malayi beta-lactamase 0.0074 0.0702 0.1854
Brugia malayi UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II 0.0346 0.3789 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0284 0.3076 0.4014
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0702 1
Leishmania major hypothetical protein, conserved 0.0074 0.0702 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0702 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0067 0.0137
Trypanosoma cruzi major cysteine proteinase, putative 0.0055 0.0485 0.6668
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0067 0.0137
Loa Loa (eye worm) hypothetical protein 0.0049 0.041 0.1005
Leishmania major hypothetical protein, conserved 0.0049 0.0419 0.5668
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0655 0.9281
Schistosoma mansoni hypothetical protein 0.0049 0.041 0.0498
Loa Loa (eye worm) hypothetical protein 0.0022 0.0112 0.0212
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0075 0.0171
Onchocerca volvulus Huntingtin homolog 0.0131 0.1342 0.5085
Brugia malayi hypothetical protein 0.0035 0.026 0.0686
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0022 0.0112 0.1785
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0333 0.1211
Leishmania major cathepsin L-like protease 0.007 0.0655 0.9281
Brugia malayi Cathepsin L-like precursor 0.0018 0.0067 0.0177
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0067 0.0092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0067 0.0137
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0284 0.3076 0.3054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0655 0.9281
Loa Loa (eye worm) hypothetical protein 0.0131 0.1342 0.3485
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0067 0.0137
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0015 0.0032 0.0086
Entamoeba histolytica hypothetical protein 0.0035 0.026 0.7634
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0059 0.0524 0.1309
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0412 0.0501
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0067 0.0046
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.041 0.0498
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0655 0.9281
Onchocerca volvulus 0.0036 0.027 0.0922
Brugia malayi Melatonin receptor type 1A 0.0015 0.0032 0.0086
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.054 0.067
Toxoplasma gondii ABC1 family protein 0.0074 0.0702 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.1342 0.3485
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.026 0.03
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0702 0.2699
Onchocerca volvulus 0.0074 0.0702 0.2603
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0077 0.0436
Leishmania major methionyl-tRNA synthetase, putative 0.0059 0.0524 0.7273
Entamoeba histolytica hypothetical protein 0.0035 0.026 0.7634
Schistosoma mansoni cpg binding protein 0.0035 0.0249 0.0286
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0338 0.0403
Echinococcus multilocularis cysteine protease 0.0018 0.0067 0.0035
Loa Loa (eye worm) hypothetical protein 0.0049 0.0419 0.103
Brugia malayi larval opioid receptor 0.0015 0.0032 0.0086
Schistosoma mansoni hypothetical protein 0.0035 0.026 0.03
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0333 0.1211
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0412 0.0381
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0284 0.3076 0.8118
Mycobacterium ulcerans hypothetical protein 0.0074 0.0702 1
Leishmania major cathepsin L-like protease 0.0018 0.0067 0.0277
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0419 0.5545
Brugia malayi Heterochromatin protein 1 0.0075 0.0706 0.1864
Loa Loa (eye worm) hypothetical protein 0.0074 0.0702 0.1783
Brugia malayi PHD-finger family protein 0.0029 0.0189 0.0499
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0067 0.0137
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0655 0.9281
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0284 0.3076 0.4014
Schistosoma mansoni tar DNA-binding protein 0.007 0.065 0.0814
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0702 0.0884
Loa Loa (eye worm) hypothetical protein 0.0078 0.0742 0.1889
Brugia malayi CXXC zinc finger family protein 0.0031 0.0205 0.0542
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.0624 0.0594
Echinococcus granulosus geminin 0.0331 0.361 0.4718
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0071 0.0051
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0702 0.1207
Brugia malayi Dopamine receptor 0.0015 0.0032 0.0086
Schistosoma mansoni tar DNA-binding protein 0.007 0.065 0.0814
Leishmania major cathepsin L-like protease 0.007 0.0655 0.9281
Onchocerca volvulus 0.0018 0.0067 0.0134
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0067 0.0035
Brugia malayi beta-lactamase family protein 0.0074 0.0702 0.1854
Toxoplasma gondii exonuclease III APE 0.0019 0.0077 0.0164
Plasmodium falciparum methionine--tRNA ligase 0.0059 0.0524 1
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0022 0.0112 0.0105
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0702 0.1783
Plasmodium vivax methionine--tRNA ligase, putative 0.0022 0.0112 0.0709
Chlamydia trachomatis leucine--tRNA ligase 0.0022 0.0112 0.5
Schistosoma mansoni cpg binding protein 0.0031 0.0205 0.0228
Echinococcus granulosus microtubule associated protein 2 0.0683 0.7616 1
Loa Loa (eye worm) ctsf protein 0.0018 0.0067 0.0092
Echinococcus multilocularis chromobox protein 1 0.0075 0.0706 0.0676
Brugia malayi hypothetical protein 0.0015 0.0032 0.0086
Trichomonas vaginalis chromobox protein, putative 0.0045 0.037 0.1357
Loa Loa (eye worm) hypothetical protein 0.0049 0.0412 0.1011
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0702 1
Brugia malayi AKH receptor 0.0015 0.0032 0.0086
Brugia malayi Dopamine receptor protein 1 0.0015 0.0032 0.0086
Onchocerca volvulus 0.0074 0.0702 0.2603
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.032 0.4141
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0075 0.0171
Echinococcus granulosus dnaJ subfamily B 0.0437 0.4812 0.6303
Onchocerca volvulus 0.0018 0.0067 0.0134
Echinococcus multilocularis geminin 0.0331 0.361 0.3589
Schistosoma mansoni inositol monophosphatase 0.0041 0.032 0.0379
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0022 0.0112 0.0555
Schistosoma mansoni hypothetical protein 0.0049 0.041 0.0498
Onchocerca volvulus 0.0018 0.0067 0.0134
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0419 0.5668
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.032 0.0379
Giardia lamblia Leucyl-tRNA synthetase 0.0022 0.0112 0.0776
Brugia malayi G protein-coupled receptor 0.0015 0.0032 0.0086
Schistosoma mansoni tar DNA-binding protein 0.007 0.065 0.0814
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0702 0.1207
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0655 0.9281
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.054 0.7404
Onchocerca volvulus 0.0074 0.0702 0.2603
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0077 0.0179
Brugia malayi Cathepsin L-like precursor 0.0018 0.0067 0.0177
Brugia malayi neuropeptide F receptor 0.0015 0.0032 0.0086
Loa Loa (eye worm) hypothetical protein 0.0105 0.1051 0.2711
Brugia malayi Pre-SET motif family protein 0.0206 0.2192 0.5784
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0015 0.0032 0.0086
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.0346 0.3789 0.4954
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.032 1
Trichomonas vaginalis esterase, putative 0.0074 0.0702 0.2699
Loa Loa (eye worm) hypothetical protein 0.0045 0.0367 0.0891
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0702 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0067 0.0137
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0067 0.0137
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0067 0.0137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0067 0.0137
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0067 0.0035
Brugia malayi Serotonin receptor 0.0015 0.0032 0.0086
Mycobacterium leprae Probable lipase LipE 0.0074 0.0702 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0702 0.0672
Brugia malayi hypothetical protein 0.0015 0.0032 0.0086
Leishmania major leucyl-tRNA synthetase, putative 0.0022 0.0112 0.0966
Mycobacterium tuberculosis Conserved protein 0.0074 0.0702 0.1207
Brugia malayi hypothetical protein 0.0015 0.0032 0.0086
Schistosoma mansoni inositol monophosphatase 0.0041 0.032 0.0379
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.037 0.1309
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0075 0.0171
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0067 0.0134
Loa Loa (eye worm) inositol-1 0.0041 0.032 0.0764
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0067 0.0137
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0077 0.0436
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.032 0.4141
Schistosoma mansoni chromobox protein 0.0075 0.0706 0.0889
Toxoplasma gondii tRNA ligases class I (M) protein 0.0022 0.0112 0.0709
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0154 0.1603 0.4182
Loa Loa (eye worm) hypothetical protein 0.0018 0.0067 0.0092
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0116 0.0221
Loa Loa (eye worm) cysteine protease 0.0018 0.0067 0.0092
Chlamydia trachomatis methionine--tRNA ligase 0.0022 0.0112 0.5
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0112 0.0709
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0702 0.2699
Brugia malayi Calcitonin receptor-like protein seb-1 0.0154 0.1603 0.4231
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0067 0.0137
Schistosoma mansoni microtubule-associated protein tau 0.0683 0.7616 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0333 0.1169
Onchocerca volvulus 0.0018 0.0067 0.0134
Echinococcus multilocularis leucyl tRNA synthetase 0.0022 0.0112 0.008

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 6.25 ug ml-1 Antibacterial activity against Escherichia coli ATCC 26032 after 24 hrs by serial dilution method ChEMBL. 20933408
MIC (functional) = 25 ug ml-1 Antifungal activity against Candida albicans ATCC 3430 after 72 to 96 hrs by serial dilution method ChEMBL. 20933408
MIC (functional) = 25 ug ml-1 Antifungal activity against Cryptococcus neoformans ATCC 3235 after 72 to 96 hrs by serial dilution method ChEMBL. 20933408

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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