Detailed information for compound 1254871

Basic information

Technical information
  • TDR Targets ID: 1254871
  • Name: N-[2-(cyclohexylamino)-2-oxo-1-thiophen-2-yle thyl]-N'-(5-methyl-1,2-oxazol-3-yl)-N-phenylb utanediamide
  • MW: 494.606 | Formula: C26H30N4O4S
  • H donors: 2 H acceptors: 4 LogP: 3.77 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1noc(c1)C)CCC(=O)N(C(c1cccs1)C(=O)NC1CCCCC1)c1ccccc1
  • InChi: 1S/C26H30N4O4S/c1-18-17-22(29-34-18)28-23(31)14-15-24(32)30(20-11-6-3-7-12-20)25(21-13-8-16-35-21)26(33)27-19-9-4-2-5-10-19/h3,6-8,11-13,16-17,19,25H,2,4-5,9-10,14-15H2,1H3,(H,27,33)(H,28,29,31)
  • InChiKey: GAFKMAONOCUFET-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[2-(cyclohexylamino)-2-oxo-1-(2-thienyl)ethyl]-N'-(5-methylisoxazol-3-yl)-N-phenyl-butanediamide
  • N-[2-(cyclohexylamino)-2-oxo-1-(2-thienyl)ethyl]-N'-(5-methyl-3-isoxazolyl)-N-phenylbutanediamide
  • N-[2-(cyclohexylamino)-2-keto-1-(2-thienyl)ethyl]-N'-(5-methylisoxazol-3-yl)-N-phenyl-succinamide
  • N-[2-(cyclohexylamino)-2-oxo-1-thiophen-2-yl-ethyl]-N'-(5-methyl-1,2-oxazol-3-yl)-N-phenyl-butanediamide
  • N-(Cyclohexylcarbamoyl-thiophen-2-yl-methyl)-N'-(5-methyl-isoxazol-3-yl)-N-phenyl-succinamide
  • SMR000117663
  • ASN 05442476
  • MLS000527189

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.001 0.0123 0.0305
Echinococcus granulosus death domain containing protein 0.0016 0.0231 0.0227
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.009 0.0086
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0123 0.012
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0123 0.012
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative 0.0005 0.0009 0.0024
Brugia malayi nuclear receptor NHR-67 0.0005 0.0013 0.0023
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0659 0.0656
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0196 0.3926 1
Echinococcus multilocularis geminin 0.0183 0.3647 0.3644
Loa Loa (eye worm) hypothetical protein 0.0005 0.0024 0.0053
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0133 0.0129
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0133 0.0129
Schistosoma mansoni thyroid hormone receptor 0.001 0.0123 0.012
Schistosoma mansoni nuclear receptor 0.0005 0.0013 0.0009
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0196 0.3926 1
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0013 0.0176 0.0447
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0123 0.0305
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0023
Schistosoma mansoni coup transcription factor 0.001 0.0123 0.012
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0825 0.2082
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0013 0.0176 0.0447
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0729 1
Brugia malayi isocitrate dehydrogenase 0.0019 0.0303 0.0765
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0123 0.012
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0023
Schistosoma mansoni nuclear receptor nhr-48 0.0005 0.0013 0.0009
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0012 0.0168 0.1951
Brugia malayi Inositol monophosphatase family protein 0.0005 0.0009 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0123 0.0305
Brugia malayi Smad1 0.001 0.0114 0.0283
Schistosoma mansoni hypothetical protein 0.0183 0.3647 0.3644
Brugia malayi nuclear receptor RXR 0.0005 0.0024 0.0053
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0024 0.0021
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0303 0.0751
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0123 0.012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0005 0.0013 0.0009
Brugia malayi Cytochrome P450 family protein 0.0012 0.0168 0.042
Onchocerca volvulus 0.0013 0.0176 0.0438
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0622 0.1577
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0196 0.3926 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0176 0.0447
Onchocerca volvulus Inositol monophosphatase 3 homolog 0.0005 0.0009 0.0015
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0123 0.012
Brugia malayi Protein kinase domain containing protein 0.0016 0.0231 0.0579
Brugia malayi MH2 domain containing protein 0.0144 0.2858 0.7276
Echinococcus multilocularis cpg binding protein 0.0037 0.0662 0.0659
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0303 0.0751
Schistosoma mansoni cpg binding protein 0.0037 0.0662 0.0659
Loa Loa (eye worm) hypothetical protein 0.0005 0.0024 0.0053
Onchocerca volvulus 0.0036 0.0659 0.1671
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0825 0.2082
Loa Loa (eye worm) hypoxia-induced factor 1 0.0153 0.3029 0.7714
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0196 0.3926 1
Brugia malayi nuclear receptor NHR-88 0.0005 0.0013 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0176 0.0447
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0074 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0074 0.0189
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0114 0.0111
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0123 0.012
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0013 0.0176 0.0172
Onchocerca volvulus 0.0035 0.0622 0.1577
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0024 0.0021
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0825 0.21
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0231 0.0227
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0123 0.0305
Echinococcus granulosus nuclear receptor nhr 48 0.0005 0.0013 0.0009
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0123 0.0305
Brugia malayi hypothetical protein 0.0005 0.0024 0.0053
Onchocerca volvulus Netrin receptor homolog 0.0016 0.0231 0.0579
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0013 0.0009
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0123 0.012
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0005 0.0013 0.0009
Schistosoma mansoni cpg binding protein 0.0035 0.0622 0.0619
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0013 0.0009
Brugia malayi CXXC zinc finger family protein 0.0035 0.0622 0.1577
Schistosoma mansoni single-minded 0.0049 0.0921 0.0917
Loa Loa (eye worm) nuclear hormone receptor 0.0005 0.0013 0.0023
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0123 0.012
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0123 0.012
Brugia malayi nuclear hormone receptor 0.0005 0.0013 0.0023
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0015 0.0012
Onchocerca volvulus 0.001 0.0123 0.0305
Loa Loa (eye worm) hypothetical protein 0.001 0.0123 0.0305
Trypanosoma brucei cytochrome P450, putative 0.0012 0.0168 0.0406
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0123 0.0305
Loa Loa (eye worm) hypothetical protein 0.0016 0.0231 0.0579
Echinococcus multilocularis smad 0.001 0.0114 0.0111
Brugia malayi Cytochrome P450 family protein 0.0012 0.0168 0.042
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.009 0.0086
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0123 0.012
Loa Loa (eye worm) nuclear receptor NHR-67 0.0005 0.0013 0.0023
Brugia malayi nuclear hormone receptor 0.001 0.0123 0.0305
Echinococcus granulosus 3'2'5' bisphosphate nucleotidase 1 0.0005 0.0009 0.0006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0123 0.012
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0659 0.1671
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0176 0.0424
Schistosoma mansoni hypothetical protein 0.0005 0.0009 0.0006
Echinococcus multilocularis Ankyrin 0.0016 0.0233 0.023
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0024 0.0053
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.009 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0123 0.0305
Schistosoma mansoni smad 0.001 0.0114 0.0111
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0168 0.0406
Brugia malayi eukaryotic initiation factor 4A 0.0196 0.3926 1
Echinococcus granulosus single minded 2 0.0036 0.0659 0.0656
Entamoeba histolytica hypothetical protein 0.0039 0.0706 0.178
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0176 0.0424
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0013 0.0176 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0123 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0074 0.0189
Leishmania major eukaryotic initiation factor 4a, putative 0.0196 0.3926 1
Entamoeba histolytica hypothetical protein 0.0039 0.0706 0.178
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0074 0.0189
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0196 0.3926 1
Echinococcus multilocularis inositol monophosphatase 0.0005 0.0009 0.0006
Schistosoma mansoni hypothetical protein 0.0183 0.3647 0.3644
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0176 0.0447
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0123 0.0305
Brugia malayi Nuclear hormone receptor E75 0.0005 0.0013 0.0023
Schistosoma mansoni inositol monophosphatase 0.0045 0.0825 0.0821
Loa Loa (eye worm) nuclear factor I 0.0005 0.0025 0.0054
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0825 0.21
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0074 0.0189
Loa Loa (eye worm) hypothetical protein 0.0013 0.0176 0.0438
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0825 0.5
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0303 0.03
Echinococcus multilocularis aryl hydrocarbon receptor 0.0013 0.0176 0.0172
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0123 0.012
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0023
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0168 0.042
Trichomonas vaginalis helicase, putative 0.0008 0.0074 0.0189
Loa Loa (eye worm) hypothetical protein 0.001 0.0123 0.0305
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0123 0.012
Entamoeba histolytica hypothetical protein 0.0039 0.0706 0.178
Loa Loa (eye worm) DR-78 0.0005 0.0013 0.0023
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0024 0.0021
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0123 0.0305
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0176 0.0424
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.009 0.0086
Schistosoma mansoni myo inositol monophosphatase 0.0005 0.0009 0.0006
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0005 0.0013 0.0009
Treponema pallidum ATP-dependent RNA helicase 0.0196 0.3926 0.5
Echinococcus granulosus smad 0.001 0.0114 0.0111
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0023
Brugia malayi MH1 domain containing protein 0.001 0.0114 0.0283
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0238 0.4781 0.4779
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0196 0.3926 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0005 0.0013 0.0023
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0176 0.0438
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0024 0.0053
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0176 0.0447
Loa Loa (eye worm) hypothetical protein 0.0005 0.0024 0.0053
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0231 0.0579
Brugia malayi MH1 domain containing protein 0.0005 0.0025 0.0054
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0825 0.2082
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0168 0.042
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0074 0.0189
Loa Loa (eye worm) hypothetical protein 0.0165 0.3291 0.8381
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.0233 0.023
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0074 0.0189
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0231 0.0579
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0196 0.3926 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0123 0.0305
Schistosoma mansoni hypothetical protein 0.0039 0.0706 0.0703
Loa Loa (eye worm) hypothetical protein 0.001 0.0123 0.0305
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0176 0.0424
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0196 0.3926 0.3924
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0123 0.0305
Loa Loa (eye worm) inositol-1 0.0045 0.0825 0.2093
Loa Loa (eye worm) hypothetical protein 0.0005 0.0024 0.0053
Brugia malayi nuclear receptor NHR-88 0.001 0.0123 0.0305
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0005 0.0013 0.0009
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0303 0.0751
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0196 0.3926 0.3924
Brugia malayi tailless protein 0.0005 0.0013 0.0023
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.2858 0.7276
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0005 0.0009 0.0024
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0005 0.0013 0.0009
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0005 0.0013 0.0023
Brugia malayi MH2 domain containing protein 0.001 0.0114 0.0283
Trichomonas vaginalis inositol monophosphatase, putative 0.0005 0.0009 0.0024
Leishmania major cytochrome p450-like protein 0.0012 0.0168 0.0406
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0123 0.0305
Brugia malayi Nuclear hormone receptor E75 0.0005 0.0013 0.0023
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0005 0.0013 0.0009
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0303 0.0751
Onchocerca volvulus 0.0005 0.0013 0.0023
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0114 0.0111
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0123 0.0305
Brugia malayi hypothetical protein 0.0005 0.0013 0.0023
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0005 0.0013 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0123 0.0305
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0303 0.03
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0074 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0074 0.0189
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0825 0.0821
Brugia malayi hypothetical protein 0.0165 0.3291 0.8381
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0024 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0123 0.0305
Echinococcus granulosus nuclear factor of activated T cells 5 0.0238 0.4781 0.4779
Loa Loa (eye worm) hypothetical protein 0.0005 0.0009 0.0015
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0074 0.0189
Schistosoma mansoni pap-inositol-14-phosphatase 0.0005 0.0009 0.0006
Schistosoma mansoni smad1 5 8 and 0.001 0.0114 0.0111
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0825 0.0821
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0074 0.0189
Brugia malayi hypoxia-induced factor 1 0.0153 0.3029 0.7714
Brugia malayi orphan nuclear receptor NR2E1 0.0005 0.0013 0.0023
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0074 0.0189
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0023
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0921 0.0917
Echinococcus granulosus Nuclear hormone receptor HR96 0.0005 0.0013 0.0009
Echinococcus granulosus geminin 0.0183 0.3647 0.3644
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0196 0.3926 1
Schistosoma mansoni smad1 5 8 and 0.001 0.0114 0.0111
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0706 0.0703
Trichomonas vaginalis adenylate cyclase, putative 0.0013 0.0176 0.0447
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0231 0.0227
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0303 0.0751
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0303 0.03
Leishmania major protein kinase, putative 0.0013 0.0176 0.0424
Brugia malayi ecdysone receptor 0.0005 0.0013 0.0023
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0706 0.0703
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0123 0.012
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0023
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0303 0.03
Schistosoma mansoni hypothetical protein 0.0494 1 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0023
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0825 0.2082
Loa Loa (eye worm) hypothetical protein 0.001 0.0123 0.0305
Loa Loa (eye worm) hypothetical protein 0.001 0.0123 0.0305
Schistosoma mansoni cpg binding protein 0.0037 0.0662 0.0659
Brugia malayi hypothetical protein 0.0039 0.0706 0.1792
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0074 0.0189
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0123 0.0305
Schistosoma mansoni nuclear receptor 0.0005 0.0013 0.0009
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0196 0.3926 0.3924
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0123 0.012
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0123 0.0305
Echinococcus multilocularis nuclear receptor nhr 48 0.0005 0.0013 0.0009
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0023
Brugia malayi MH2 domain containing protein 0.001 0.0114 0.0283
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0123 0.0305
Brugia malayi nuclear hormone receptor family member nhr-6 0.0005 0.0013 0.0023
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0303 0.03
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0123 0.012
Loa Loa (eye worm) hypothetical protein 0.0005 0.0009 0.0015
Loa Loa (eye worm) hypothetical protein 0.0196 0.3926 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0005 0.0013 0.0009
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0303 0.0765
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0825 0.2082
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0123 0.0305
Leishmania major protein kinase, putative 0.0013 0.0176 0.0424
Echinococcus granulosus eukaryotic initiation factor 4A 0.0196 0.3926 0.3924
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0005 0.0013 0.0023
Loa Loa (eye worm) Smad1 0.001 0.0114 0.0283
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0825 0.21
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0825 0.2082
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.009 0.0086
Echinococcus granulosus inositol monophosphatase 0.0005 0.0009 0.0006
Schistosoma mansoni hypothetical protein 0.0016 0.0231 0.0227
Plasmodium vivax RNA helicase-1, putative 0.0196 0.3926 1
Echinococcus granulosus Ankyrin 0.0016 0.0233 0.023
Loa Loa (eye worm) hypothetical protein 0.0005 0.0025 0.0054
Echinococcus granulosus Nuclear hormone receptor HR96 0.0005 0.0013 0.0009
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0825 1
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0133 0.033
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0023
Echinococcus multilocularis 3'(2'),5' bisphosphate nucleotidase 1 0.0005 0.0009 0.0006
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0303 0.0751
Brugia malayi Death domain containing protein 0.0016 0.0231 0.0579
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0176 0.0424
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0123 0.0305
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0231 0.0227
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0123 0.0305
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0123 0.012
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.013 0.0323
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0123 0.012
Brugia malayi conserved hypotetical protein 0.0005 0.0013 0.0023
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0303 0.03
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0005 0.0013 0.0023
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0168 0.0406
Schistosoma mansoni Smad4 0.001 0.0114 0.0111
Schistosoma mansoni thyroid hormone receptor 0.001 0.0123 0.012
Echinococcus granulosus FTZ F1 alpha 0.001 0.0123 0.012
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0023
Loa Loa (eye worm) hypothetical protein 0.001 0.0123 0.0305
Brugia malayi MH1 domain containing protein 0.001 0.0114 0.0283
Schistosoma mansoni nuclear hormone receptor 0.001 0.0123 0.012
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0114 0.0111
Brugia malayi nuclear receptor RXR 0.0005 0.0013 0.0023
Leishmania major eukaryotic initiation factor 4a, putative 0.0196 0.3926 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0729 0.1838
Entamoeba histolytica hypothetical protein 0.0039 0.0706 0.178
Echinococcus granulosus aryl hydrocarbon receptor 0.0013 0.0176 0.0172
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.1256 0.3182
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0123 0.0305
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0706 0.0703
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0659 0.7967
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0123 0.012
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0123 0.012
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0303 0.0751
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0123 0.0305
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0196 0.3926 1
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0196 0.3926 0.3924
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0303 0.0765
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0303 0.03
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0176 0.0424
Loa Loa (eye worm) hypothetical protein 0.0005 0.0024 0.0053
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0023
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0196 0.3926 1
Brugia malayi Uncoordinated protein 44 0.0016 0.0231 0.0579
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.2858 0.7276
Loa Loa (eye worm) hypothetical protein 0.0005 0.0013 0.0023
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0123 0.012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0123 0.0305
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0231 0.0227
Brugia malayi hypothetical protein 0.0005 0.0013 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0123 0.0305
Brugia malayi Inositol monophosphatase family protein 0.0005 0.0009 0.0015
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1416 0.1413
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0123 0.0305
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0005 0.0013 0.0009
Schistosoma mansoni smad1 5 8 and 0.001 0.0114 0.0111
Schistosoma mansoni inositol monophosphatase 0.0045 0.0825 0.0821
Brugia malayi hypothetical protein 0.0005 0.0024 0.0053
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0123 0.012
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0168 0.042
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0123 0.012
Echinococcus multilocularis dnaJ subfamily B 0.0494 1 1
Brugia malayi Inositol-1 0.0045 0.0825 0.2093
Mycobacterium leprae Possible regulatory protein 0.0013 0.0176 0.2308
Echinococcus multilocularis Smad4 0.001 0.0114 0.0111
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0114 0.0283
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0176 0.0447
Echinococcus granulosus cpg binding protein 0.0037 0.0662 0.0659
Schistosoma mansoni zinc finger protein 0.0005 0.0013 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0176 0.0447
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0123 0.012
Brugia malayi steroid hormone receptor 0.001 0.0123 0.0305
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0114 0.0111
Brugia malayi MH1 domain containing protein 0.0005 0.0025 0.0054
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0013 0.0176 0.0172
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0114 0.0283
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0024 0.0021
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0231 0.0227
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0074 0.0189
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0123 0.0305
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0123 0.0305
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0196 0.3926 0.3924
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0176 0.0447
Schistosoma mansoni netrin receptor unc5 0.0016 0.0231 0.0227
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0123 0.012
Brugia malayi ecdysteroid receptor 0.001 0.0123 0.0305
Schistosoma mansoni hypothetical protein 0.0005 0.0009 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0074 0.0189
Loa Loa (eye worm) hypothetical protein 0.001 0.0123 0.0305
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0074 0.0189
Loa Loa (eye worm) hypothetical protein 0.0016 0.0233 0.0586
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0176 0.0424
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0114 0.0111
Echinococcus granulosus thyroid hormone receptor alpha 0.0005 0.0013 0.0009
Onchocerca volvulus 0.0005 0.0013 0.0023
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0176 0.0447
Plasmodium falciparum eukaryotic initiation factor 4A 0.0196 0.3926 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0005 0.0013 0.0023
Trichomonas vaginalis inositol monophosphatase, putative 0.0005 0.0009 0.0024
Echinococcus granulosus Smad4 0.001 0.0114 0.0111
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0303 0.0751
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0196 0.3926 1
Brugia malayi PAS domain containing protein 0.0049 0.0921 0.2338
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0074 0.0189
Loa Loa (eye worm) hypothetical protein 0.0009 0.0095 0.0234

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): Confirmation of Cherrypicks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 36.8977 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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