Detailed information for compound 1266441

Basic information

Technical information
  • TDR Targets ID: 1266441
  • Name: [1-(2-methyl-5-propylpyrazole-3-carbonyl)pipe ridin-3-yl]-naphthalen-1-ylmethanone
  • MW: 389.49 | Formula: C24H27N3O2
  • H donors: 0 H acceptors: 3 LogP: 4.3 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCc1nn(c(c1)C(=O)N1CCCC(C1)C(=O)c1cccc2c1cccc2)C
  • InChi: 1S/C24H27N3O2/c1-3-8-19-15-22(26(2)25-19)24(29)27-14-7-11-18(16-27)23(28)21-13-6-10-17-9-4-5-12-20(17)21/h4-6,9-10,12-13,15,18H,3,7-8,11,14,16H2,1-2H3
  • InChiKey: HDNORBGOEUUXPW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [1-(2-methyl-5-propyl-pyrazole-3-carbonyl)-3-piperidyl]-(1-naphthyl)methanone
  • [1-[(2-methyl-5-propyl-3-pyrazolyl)-oxomethyl]-3-piperidinyl]-(1-naphthyl)methanone
  • [1-(2-methyl-5-propyl-pyrazol-3-yl)carbonylpiperidin-3-yl]-naphthalen-1-yl-methanone
  • MLS000734014
  • SMR000316355
  • {1-[(1-methyl-3-propyl-1H-pyrazol-5-yl)carbonyl]piperidin-3-yl}(1-naphthyl)methanone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major DNA polymerase eta, putative 0.0019 0.0108 0.011
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.002 0.0033
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0289 0.3489 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0012 0.0014 0.0031
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0043
Brugia malayi hypothetical protein 0.0043 0.0411 0.0894
Brugia malayi Dopamine receptor protein 2 0.0012 0.0014 0.0031
Loa Loa (eye worm) hypothetical protein 0.0236 0.2822 0.6138
Loa Loa (eye worm) hypothetical protein 0.0072 0.0767 0.1668
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.002 0.0043
Trichomonas vaginalis esterase, putative 0.0072 0.0767 0.1931
Schistosoma mansoni opsin-like receptor 0.0012 0.0014 0.0024
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0378 0.4598 1
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0014 0.0014
Schistosoma mansoni amine GPCR 0.0012 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Loa Loa (eye worm) hypothetical protein 0.0133 0.1531 0.3331
Echinococcus granulosus sex peptide receptor 0.0012 0.0014 0.0024
Brugia malayi hypothetical protein 0.0012 0.0014 0.0031
Echinococcus granulosus orexin receptor type 2 0.0012 0.0014 0.0024
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0014 0.0014
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0767 0.4217
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0014 0.0024
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0089 0.0148
Echinococcus multilocularis geminin 0.0169 0.1984 0.1984
Schistosoma mansoni biogenic amine receptor 0.0012 0.0014 0.0024
Brugia malayi GnHR receptor homolog 0.0012 0.0014 0.0031
Brugia malayi hypothetical protein 0.0012 0.0014 0.0031
Schistosoma mansoni hypothetical protein 0.0082 0.0898 0.1483
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.002 0.0043
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0788 0.1302
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0108 0.0164
Brugia malayi Tachykinin-like peptides receptor 99D 0.0012 0.0014 0.0031
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0265
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.002 0.0043
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0008 0.0013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0108 0.0235
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0023 0.0051
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.002 0.0033
Brugia malayi PHD-finger family protein 0.0027 0.0203 0.0441
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.002 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0014 0.0024
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0014 0.0024
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0108 0.0235
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.002 0.002
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0012 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0012 0.0014 0.0024
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0626 0.094
Schistosoma mansoni neuropeptide f receptor 76f 0.0012 0.0014 0.0024
Brugia malayi SWIRM domain containing protein 0.002 0.0122 0.0265
Schistosoma mansoni hypothetical protein 0.0011 0.0008 0.0013
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0108 0.011
Schistosoma mansoni cpg binding protein 0.0035 0.0301 0.0498
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0767 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0108 0.0178
Echinococcus multilocularis G-protein coupled receptor, putative 0.0012 0.0014 0.0014
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.3519 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0043
Echinococcus granulosus cpg binding protein 0.0039 0.035 0.0578
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0014 0.0031
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0012 0.0014 0.0024
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0626 0.1033
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0767 0.1266
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0014 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.002 0.0043
Brugia malayi hypothetical protein 0.002 0.0122 0.0265
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0265
Schistosoma mansoni adenoreceptor 0.0012 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0265
Loa Loa (eye worm) TYRA-2 protein 0.0012 0.0014 0.0031
Schistosoma mansoni vesicular acetylcholine transporter 0.0226 0.2693 0.4448
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0626 0.1531
Brugia malayi CXXC zinc finger family protein 0.0035 0.0301 0.0655
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0108 0.0164
Echinococcus granulosus neuropeptide receptor 0.0012 0.0014 0.0024
Echinococcus granulosus dro:myosuppressin receptor 0.0012 0.0014 0.0024
Brugia malayi AKH receptor 0.0012 0.0014 0.0031
Brugia malayi G-protein coupled receptor 0.0012 0.0014 0.0031
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0626 0.1531
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0108 0.0164
Schistosoma mansoni amine GPCR 0.0012 0.0014 0.0024
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0108 0.0164
Echinococcus granulosus g protein coupled receptor 0.0012 0.0014 0.0024
Entamoeba histolytica hypothetical protein 0.0043 0.0411 0.0888
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0038 0.0344 0.0748
Loa Loa (eye worm) neuropeptide F receptor 0.0012 0.0014 0.0031
Schistosoma mansoni biogenic amine receptor 0.0012 0.0014 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.002 0.0043
Echinococcus granulosus peptide allatostatin:somatostatin 0.0012 0.0014 0.0024
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.002 0.002
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0012 0.0014 0.0024
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.002 0.002
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0626 0.125
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0014 0.0014
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Echinococcus granulosus serotonin receptor 0.0012 0.0014 0.0024
Echinococcus multilocularis allatostatin A receptor 0.0012 0.0014 0.0014
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.002 0.0043
Schistosoma mansoni cpg binding protein 0.0039 0.035 0.0578
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0296 0.0551
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0072 0.0767 0.1668
Echinococcus granulosus dna polymerase kappa 0.0019 0.0108 0.0178
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0014 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0108 0.0164
Brugia malayi Calcitonin receptor-like protein seb-1 0.012 0.1375 0.2991
Schistosoma mansoni hypothetical protein 0.0038 0.0344 0.0568
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0108 0.0108
Brugia malayi putative neuropeptide receptor 0.0012 0.0014 0.0031
Schistosoma mansoni growth hormone secretagogue receptor 0.0012 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Schistosoma mansoni hypothetical protein 0.0021 0.0125 0.0206
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.002 0.0043
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0015 0.0058 0.0096
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Leishmania major hypothetical protein, conserved 0.0072 0.0767 0.1561
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0182 0.0326
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0014 0.0024
Mycobacterium tuberculosis Conserved protein 0.0072 0.0767 0.1196
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.002 0.0033
Schistosoma mansoni cpg binding protein 0.0039 0.035 0.0578
Echinococcus multilocularis cpg binding protein 0.0039 0.035 0.035
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0292 0.3519 1
Leishmania major UDP-galactopyranose mutase 0.002 0.0122 0.0141
Brugia malayi beta-lactamase family protein 0.0072 0.0767 0.1668
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0559 0.0923
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Echinococcus multilocularis neuropeptide Y receptor 0.0012 0.0014 0.0014
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0014 0.0014
Schistosoma mansoni myosin xvIII 0.0012 0.0014 0.0024
Echinococcus granulosus neuropeptide FF receptor 2 0.0012 0.0014 0.0024
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.002 0.0033
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0012 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0072 0.0767 0.1668
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.3519 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0012 0.0014 0.0031
Loa Loa (eye worm) hypothetical protein 0.0072 0.0767 0.1668
Echinococcus multilocularis GPCR, family 2 0.0038 0.0344 0.0344
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0108 0.011
Schistosoma mansoni biogenic amine (5HT) receptor 0.0133 0.1531 0.2529
Echinococcus granulosus alpha 1A adrenergic receptor 0.0012 0.0014 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.002 0.0043
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0012 0.0014 0.0014
Chlamydia trachomatis protoporphyrinogen oxidase 0.002 0.0122 0.5
Onchocerca volvulus 0.0072 0.0767 0.2809
Brugia malayi hypothetical protein 0.0012 0.0014 0.0031
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.6054 0.6054
Schistosoma mansoni amine GPCR 0.0012 0.0014 0.0024
Schistosoma mansoni histamine h1 receptor 0.0012 0.0014 0.0024
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0088 0.0191
Echinococcus multilocularis serotonin receptor 0.0133 0.1531 0.1531
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.002 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.002 0.0043
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0559 0.1215
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.002 0.0043
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.008 0.0132
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.002 0.0043
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.002 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0014 0.0014
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0012 0.0014 0.0031
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0265
Brugia malayi putative neuropeptide receptor NPR1 0.0012 0.0014 0.0031
Loa Loa (eye worm) hypothetical protein 0.0032 0.0266 0.0578
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0142 0.1651 0.4563
Brugia malayi ORL1-like opioid receptor 0.0012 0.0014 0.0031
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0142 0.1651 0.2801
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0411 0.0679
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0043
Schistosoma mansoni hypothetical protein 0.0012 0.0014 0.0024
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0559 0.0559
Echinococcus granulosus g protein coupled receptor 0.0012 0.0014 0.0024
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0012 0.0014 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.002 0.0043
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.047 0.1021
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.002 0.0043
Brugia malayi Latrophilin receptor protein 2 0.0038 0.0344 0.0748
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0014 0.0024
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0038 0.0344 0.0568
Echinococcus granulosus zinc finger protein 0.0022 0.0136 0.0225
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0559 0.0923
Brugia malayi latrophilin 2 splice variant baaae 0.0082 0.0898 0.1953
Echinococcus granulosus lysine specific histone demethylase 1A 0.002 0.0122 0.0201
Schistosoma mansoni hypothetical protein 0.0012 0.0014 0.0024
Schistosoma mansoni nuclear hormone receptor 0.0012 0.002 0.0033
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0012 0.0014 0.0024
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0014 0.0024
Echinococcus granulosus hypothetical protein 0.0012 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0767 0.1931
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.002 0.0043
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Echinococcus granulosus GPCR family 2 0.0038 0.0344 0.0568
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0012 0.0014 0.0031
Schistosoma mansoni neuropeptide receptor 0.0012 0.0014 0.0024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0014 0.0014
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.002 0.002
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0626 0.1033
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0169 0.1984 0.3278
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0767 0.1931
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0012 0.0014 0.0024
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0012 0.0014 0.0031
Onchocerca volvulus 0.0072 0.0767 0.2809
Brugia malayi G protein-coupled receptor F59B2.13 0.0012 0.0014 0.0031
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Schistosoma mansoni Lysine-specific histone demethylase 1 0.002 0.0122 0.0201
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0014 0.0024
Echinococcus granulosus neuropeptide receptor A26 0.0012 0.0014 0.0024
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0014 0.0024
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0173 0.0286
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0038 0.0344 0.0344
Trypanosoma brucei C-8 sterol isomerase, putative 0.0378 0.4598 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0012 0.0014 0.0014
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0767 0.0767
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0269 0.3234 0.5676
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0014 0.0014
Echinococcus granulosus lysine specific histone demethylase 1A 0.002 0.0122 0.0201
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0012 0.0014 0.0031
Mycobacterium ulcerans dehydrogenase 0.002 0.0122 0.0041
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0014 0.0024
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0767 0.1266
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Onchocerca volvulus 0.002 0.0122 0.0402
Trypanosoma cruzi UDP-galactopyranose mutase 0.002 0.0122 0.0141
Loa Loa (eye worm) hypothetical protein 0.0045 0.0425 0.0923
Giardia lamblia Fructose-bisphosphate aldolase 0.0292 0.3519 1
Echinococcus granulosus allatostatin A receptor 0.0012 0.0014 0.0024
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0182 0.0929
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0012 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.012 0.1375 0.2991
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Loa Loa (eye worm) hypothetical protein 0.0038 0.0344 0.0748
Mycobacterium tuberculosis Conserved protein 0.0072 0.0767 0.1196
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0014 0.0024
Brugia malayi neuropeptide F receptor 0.0012 0.0014 0.0031
Echinococcus granulosus dna polymerase eta 0.0019 0.0108 0.0178
Schistosoma mansoni hypothetical protein 0.0048 0.047 0.0776
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0014 0.0024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.3519 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0173 0.0286
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.002 0.0043
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0369 0.0609
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0767 0.1196
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0014 0.0024
Onchocerca volvulus 0.0072 0.0767 0.2809
Schistosoma mansoni thyroid hormone receptor 0.0012 0.002 0.0033
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0301 0.0655
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0638 0.1053
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0038 0.0344 0.0344
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0043
Onchocerca volvulus 0.0012 0.002 0.002
Schistosoma mansoni neuropeptide receptor 0.0012 0.0014 0.0024
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.002 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0108 0.0164
Brugia malayi nuclear receptor NHR-88 0.0012 0.002 0.0043
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0014 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0108 0.0164
Brugia malayi hypothetical protein 0.0012 0.0014 0.0031
Mycobacterium tuberculosis Conserved protein 0.0072 0.0767 0.1196
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0014 0.0024
Brugia malayi sulfakinin receptor protein 0.0012 0.0014 0.0031
Trypanosoma brucei ISWI complex protein 0.0015 0.0058 0.0054
Brugia malayi steroid hormone receptor 0.0012 0.002 0.0043
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0108 0.0178
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.002 0.0043
Schistosoma mansoni biogenic amine receptor 0.0012 0.0014 0.0024
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0767 0.1196
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0043
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0014 0.0031
Schistosoma mansoni hypothetical protein 0.0038 0.0344 0.0568
Brugia malayi Serotonin receptor 0.0012 0.0014 0.0031
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0142 0.1651 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0289 0.3489 1
Brugia malayi hypothetical protein 0.0236 0.2822 0.6138
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0182 0.0273
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.002 0.0033
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0265
Mycobacterium ulcerans lipase LipD 0.0072 0.0767 0.1948
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0012 0.0014 0.0014
Echinococcus granulosus dnaJ subfamily B 0.0494 0.6054 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0089 0.0195
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0108 0.0164
Brugia malayi amine oxidase, flavin-containing family protein 0.002 0.0122 0.0265
Loa Loa (eye worm) hypothetical protein 0.0133 0.1531 0.3331
Brugia malayi larval opioid receptor 0.0012 0.0014 0.0031
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0767 0.1931
Schistosoma mansoni hypothetical protein 0.0012 0.0014 0.0024
Echinococcus granulosus neuropeptides capa receptor 0.0012 0.0014 0.0024
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0108 0.0164
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.3519 1
Echinococcus granulosus g protein coupled receptor 0.0012 0.0014 0.0024
Echinococcus multilocularis sex peptide receptor 0.0012 0.0014 0.0014
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0014 0.0014
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0038 0.0344 0.0568
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.008 0.0132
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0012 0.0014 0.0031
Echinococcus granulosus somatostatin receptor 0.0012 0.0014 0.0024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.3519 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.002 0.0043
Schistosoma mansoni hypothetical protein 0.0169 0.1984 0.3278
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0014 0.0024
Loa Loa (eye worm) pigment dispersing factor receptor c 0.012 0.1375 0.2991
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.008 0.0132
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.002 0.0033
Schistosoma mansoni opsin-like receptor 0.0012 0.0014 0.0024
Echinococcus multilocularis zinc finger protein 0.0022 0.0136 0.0136
Leishmania major C-8 sterol isomerase-like protein 0.0378 0.4598 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Mycobacterium tuberculosis Possible oxidoreductase 0.002 0.0122 0.0025
Loa Loa (eye worm) hypothetical protein 0.0378 0.4598 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.002 0.0033
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0012 0.0014 0.0014
Brugia malayi vesicular acetylcholine transporter unc-17 0.0226 0.2693 0.5858
Brugia malayi Serotonin receptor 0.0012 0.0014 0.0031
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0108 0.011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.002 0.0043
Mycobacterium ulcerans monoamine oxidase 0.002 0.0122 0.0041
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.002 0.002
Echinococcus multilocularis dna polymerase eta 0.0019 0.0108 0.0108
Schistosoma mansoni alpha-1 adrenergic receptor 0.0012 0.0014 0.0024
Brugia malayi hypothetical protein 0.0016 0.007 0.0153
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.002 0.0122 0.0201
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0559 0.0923
Onchocerca volvulus 0.0035 0.0301 0.1071
Schistosoma mansoni amine GPCR 0.0012 0.0014 0.0024
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.002 0.0033
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0012 0.0014 0.0024
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0014 0.0014
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0012 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0494 0.6054 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0767 0.1196
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0014 0.0024
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0108 0.011
Leishmania major DNA polymerase kappa, putative 0.0019 0.0108 0.011
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0296 0.0551
Entamoeba histolytica hypothetical protein 0.0043 0.0411 0.0888
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.002 0.0043
Mycobacterium ulcerans beta-lactamase 0.0072 0.0767 0.1948
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Leishmania major hypothetical protein, conserved 0.0025 0.0182 0.0273
Echinococcus multilocularis lysine specific histone demethylase 1A 0.002 0.0122 0.0122
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0108 0.011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Brugia malayi hypothetical protein 0.0025 0.0182 0.0396
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Loa Loa (eye worm) melatonin receptor type 1A 0.0012 0.0014 0.0031
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0012 0.0014 0.0014
Brugia malayi nuclear hormone receptor 0.0012 0.002 0.0043
Echinococcus multilocularis somatostatin receptor 0.0012 0.0014 0.0014
Echinococcus multilocularis 0.002 0.0122 0.0122
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0008 0.0008
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0108 0.0108
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0182 1
Schistosoma mansoni hypothetical protein 0.0043 0.0411 0.0679
Schistosoma mansoni coup transcription factor 0.0012 0.002 0.0033
Mycobacterium leprae Probable lipase LipE 0.0072 0.0767 0.4217
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.002 0.002
Echinococcus multilocularis dro:myosuppressin receptor 0.0012 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0012 0.0014 0.0014
Brugia malayi Dopamine receptor 0.0012 0.0014 0.0031
Schistosoma mansoni bromodomain containing protein 0.0065 0.0682 0.1127
Echinococcus multilocularis fmrfamide receptor 0.0012 0.0014 0.0014
Brugia malayi hypothetical protein 0.0012 0.0014 0.0031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0559 0.0923
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0767 0.1668
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0014 0.0024
Brugia malayi hypothetical protein 0.0012 0.0014 0.0031
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0089 0.0148
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0012 0.0014 0.0024
Echinococcus granulosus fmrfamide receptor 0.0012 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Loa Loa (eye worm) hypothetical protein 0.0193 0.2285 0.497
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0767 0.1266
Schistosoma mansoni thyroid hormone receptor 0.0012 0.002 0.0033
Echinococcus multilocularis g-protein coupled receptor 0.0012 0.0014 0.0014
Brugia malayi follicle stimulating hormone receptor 0.0012 0.0014 0.0031
Trypanosoma cruzi UDP-galactopyranose mutase 0.002 0.0122 0.0141
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.2822 0.4661
Loa Loa (eye worm) hypothetical protein 0.0082 0.0898 0.1953
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.002 0.0033
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.002 0.0033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0559 0.0923
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0014 0.0024
Echinococcus multilocularis protoporphyrinogen oxidase 0.002 0.0122 0.0122
Loa Loa (eye worm) latrophilin receptor protein 2 0.0038 0.0344 0.0748
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0043
Treponema pallidum fructose-bisphosphate aldolase 0.0292 0.3519 0.5
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0125 0.0271
Mycobacterium ulcerans hypothetical protein 0.0072 0.0767 0.1948
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0089 0.0148
Schistosoma mansoni amine oxidase 0.002 0.0122 0.0201
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0411 0.0411
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0378 0.4598 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0376 0.0818
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0226 0.2693 1
Schistosoma mansoni amine oxidase 0.002 0.0122 0.0201
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0108 0.0164
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0108 0.0235
Echinococcus multilocularis g protein coupled receptor 0.0012 0.0014 0.0014
Echinococcus granulosus neuropeptide s receptor 0.0012 0.0014 0.0024
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0411 0.0679
Brugia malayi Bromodomain containing protein 0.0077 0.0829 0.1803
Brugia malayi Bromodomain containing protein 0.0038 0.0345 0.0751
Brugia malayi G-protein coupled receptor 0.0012 0.0014 0.0031
Echinococcus multilocularis vesicular acetylcholine transporter 0.0226 0.2693 0.2693
Brugia malayi beta-lactamase family protein 0.0072 0.0767 0.1668
Echinococcus multilocularis neuropeptides capa receptor 0.0012 0.0014 0.0014
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0012 0.0014 0.0024
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.0326 0.071
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0014 0.0024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0014 0.0014
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0292 0.3519 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0122 0.0025
Loa Loa (eye worm) hypothetical protein 0.0071 0.0751 0.1633
Echinococcus granulosus neuropeptide Y receptor 0.0012 0.0014 0.0024
Echinococcus multilocularis orexin receptor type 2 0.0012 0.0014 0.0014
Echinococcus multilocularis neuropeptide receptor A26 0.0012 0.0014 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0767 0.1561
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0022 0.0148 0.0411
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.3519 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.3519 1
Entamoeba histolytica hypothetical protein 0.0043 0.0411 0.0888
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0012 0.0014 0.0024
Echinococcus granulosus tm gpcr rhodopsin 0.0012 0.0014 0.0024
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0369 0.0609
Echinococcus multilocularis neuropeptide receptor 0.0012 0.0014 0.0014
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0182 0.0929
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0108 0.0178
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0326 0.071
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0767 0.1668
Schistosoma mansoni zinc finger protein 0.0015 0.0058 0.0096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.002 0.0043
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Echinococcus granulosus G protein coupled receptor 139 0.0012 0.0014 0.0024
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0767 0.1607
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0182 1
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0767 0.1196
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0043
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0089 0.0089
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.012 0.1375 0.2991
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0767 0.1931
Brugia malayi G protein-coupled receptor 0.0012 0.0014 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.002 0.0043
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0012 0.0014 0.0014
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0012 0.0014 0.0024
Brugia malayi Dopamine receptor protein 1 0.0012 0.0014 0.0031
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0038 0.0344 0.0568
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.002 0.002
Echinococcus granulosus neuropeptide receptor 0.0012 0.0014 0.0024
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0226 0.2693 0.5858
Echinococcus granulosus biogenic amine 5HT receptor 0.0133 0.1531 0.2529
Onchocerca volvulus 0.0048 0.047 0.17
Schistosoma mansoni biogenic amine (5HT) receptor 0.0012 0.0014 0.0024
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0012 0.0014 0.0031
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0108 0.011
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.2822 0.2822
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Echinococcus granulosus 7TM GPCR rhodopsin 0.0012 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0038 0.0346 0.0753
Echinococcus granulosus geminin 0.0169 0.1984 0.3278
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0292 0.3519 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0014 0.0014
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.002 0.0033
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0559 0.1215
Loa Loa (eye worm) beta-lactamase 0.0072 0.0767 0.1668
Echinococcus granulosus biogenic amine 5HT receptor 0.0012 0.0014 0.0024
Schistosoma mansoni amine GPCR 0.0012 0.0014 0.0024
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0316 0.0522
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.002 0.0043
Schistosoma mansoni hypothetical protein 0.0012 0.0014 0.0024
Schistosoma mansoni zinc finger protein 0.0022 0.0136 0.0225
Mycobacterium ulcerans protoporphyrinogen oxidase 0.002 0.0122 0.0041
Schistosoma mansoni opsin-like receptor 0.0012 0.0014 0.0024
Brugia malayi hypothetical protein 0.0012 0.0014 0.0031
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0012 0.0014 0.0024
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0767 0.1948
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0626 0.1531
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0182 0.0273
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0767 0.1561
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0001 0.0002
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0767 0.1948
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0108 0.0164
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0626 0.1033
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.002 0.0033
Trypanosoma brucei unspecified product 0.0019 0.0108 0.0164
Brugia malayi RE15519p 0.0012 0.0014 0.0031
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.002 0.0033
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0012 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Loa Loa (eye worm) G-protein coupled receptor 0.0012 0.0014 0.0031
Toxoplasma gondii ABC1 family protein 0.0072 0.0767 1
Schistosoma mansoni neuropeptide F-like receptor 0.0012 0.0014 0.0024
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0767 0.1196
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0326 0.0539
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0626 0.7812
Brugia malayi ecdysteroid receptor 0.0012 0.002 0.0043
Mycobacterium ulcerans oxidoreductase 0.002 0.0122 0.0041
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0014 0.0024
Entamoeba histolytica hypothetical protein 0.0043 0.0411 0.0888
Echinococcus multilocularis serotonin receptor 0.0133 0.1531 0.1531
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0626 0.0626
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.002 0.0033
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0108 0.0235
Schistosoma mansoni neuropeptide receptor 0.0012 0.0014 0.0024
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0767 0.1931
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.002 0.002
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0767 0.1196
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.002 0.002
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0638 0.0638
Brugia malayi hypothetical protein 0.0012 0.0014 0.0031
Echinococcus granulosus g-protein coupled receptor 0.0012 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0072 0.0767 0.1668
Echinococcus granulosus vesicular acetylcholine transporter 0.0226 0.2693 0.4448
Brugia malayi beta-lactamase 0.0072 0.0767 0.1668
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0012 0.0014 0.0031
Schistosoma mansoni hypothetical protein 0.0038 0.0344 0.0568
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0459 0.5616 1
Schistosoma mansoni neuropeptide receptor 0.0012 0.0014 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.002 0.0043
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0014 0.0024
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0316 0.0316
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0108 0.0164
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0108 0.0164
Schistosoma mansoni survival motor neuron protein 0.0048 0.047 0.0776
Brugia malayi neuropeptide F receptor 0.0012 0.0014 0.0031
Echinococcus granulosus tachykinin peptides receptor 99D 0.0012 0.0014 0.0024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0012 0.0014 0.0024
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0559 0.0559
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0012 0.0014 0.0031
Loa Loa (eye worm) hypothetical protein 0.002 0.0122 0.0265
Brugia malayi hypothetical protein 0.0012 0.0014 0.0031
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.002 0.0033
Brugia malayi hypothetical protein 0.0012 0.0014 0.0031
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0767 0.1196
Echinococcus granulosus FTZ F1 alpha 0.0012 0.002 0.0033
Schistosoma mansoni DNA polymerase eta 0.0019 0.0108 0.0178
Loa Loa (eye worm) hypothetical protein 0.0072 0.0767 0.1668
Brugia malayi Melatonin receptor type 1A 0.0012 0.0014 0.0031
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.002 0.0043
Echinococcus granulosus 7tm_1 domain containing protein 0.0012 0.0014 0.0024
Echinococcus multilocularis neuropeptide s receptor 0.0012 0.0014 0.0014
Toxoplasma gondii histone lysine methyltransferase SET1 0.0068 0.072 0.9268
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0012 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0012 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0025 0.0182 0.0396
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0108 0.0164
Echinococcus multilocularis G protein coupled receptor 139 0.0012 0.0014 0.0014
Echinococcus granulosus rhodopsin orphan GPCR 0.0012 0.0014 0.0024
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0326 0.0326
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0173 0.0173
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0012 0.0014 0.0014

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.9953 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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