Detailed information for compound 1270466

Basic information

Technical information
  • TDR Targets ID: 1270466
  • Name: N-[4-[4-(furan-2-carbonyl)piperazine-1-carbon yl]phenyl]-2-methylpropanamide
  • MW: 369.414 | Formula: C20H23N3O4
  • H donors: 1 H acceptors: 3 LogP: 1.93 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(C)C)Nc1ccc(cc1)C(=O)N1CCN(CC1)C(=O)c1ccco1
  • InChi: 1S/C20H23N3O4/c1-14(2)18(24)21-16-7-5-15(6-8-16)19(25)22-9-11-23(12-10-22)20(26)17-4-3-13-27-17/h3-8,13-14H,9-12H2,1-2H3,(H,21,24)
  • InChiKey: OXBLIIWNBNSVTH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-[4-(furan-2-carbonyl)piperazine-1-carbonyl]phenyl]-2-methyl-propanamide
  • N-[4-[[4-(2-furyl-oxomethyl)-1-piperazinyl]-oxomethyl]phenyl]-2-methylpropanamide
  • N-[4-[4-(furan-2-carbonyl)piperazine-1-carbonyl]phenyl]-2-methyl-propionamide
  • N-[4-(4-furan-2-ylcarbonylpiperazin-1-yl)carbonylphenyl]-2-methyl-propanamide
  • N-{4-[4-(Furan-2-carbonyl)-piperazine-1-carbonyl]-phenyl}-isobutyramide
  • SMR000015117
  • ZINC00691910
  • BAS 09537496
  • MLS000030164

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi calpain 5 0.0019 0.0045 0.0105
Trypanosoma cruzi agmatinase, putative 0.0062 0.0309 0.1044
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0116 0.0352
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0006 0.0007
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0022 0.0066 0.0145
Onchocerca volvulus 0.0725 0.4335 1
Trypanosoma brucei Carboxypeptidase-like protein 0.0022 0.0066 0.022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0483 0.0478
Loa Loa (eye worm) hypothetical protein 0.0022 0.0066 0.0149
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0045 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0092 0.0205
Brugia malayi Zinc carboxypeptidase family protein 0.0022 0.0066 0.0153
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0022 0.0066 0.022
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0164 1
Loa Loa (eye worm) calpain 5 0.0019 0.0045 0.0101
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0024 0.0021
Echinococcus granulosus GPCR family 2 0.0032 0.013 0.0126
Onchocerca volvulus 0.0022 0.0066 0.0145
Trypanosoma brucei agmatinase, putative 0.0062 0.0309 0.1044
Loa Loa (eye worm) thioredoxin reductase 0.0044 0.0198 0.0454
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0092 0.0205
Schistosoma mansoni peptidase 0.0022 0.0066 0.0062
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0496 0.2947 0.2944
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0022 0.0066 0.0218
Trichomonas vaginalis helicase, putative 0.0026 0.0092 0.0205
Onchocerca volvulus 0.0033 0.0135 0.0304
Echinococcus multilocularis survival motor neuron protein 1 0.0712 0.4255 0.4253
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0111 0.0607 0.1352
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0164 0.0374
Schistosoma mansoni myst-related protein 0.0014 0.0016 0.0011
Loa Loa (eye worm) hypothetical protein 0.007 0.0359 0.0824
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0045 0.0149
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0164 0.0504
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0141 0.0438
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0116 0.0112
Echinococcus multilocularis geminin 0.0675 0.4032 0.403
Plasmodium vivax calpain, putative 0.0019 0.0045 0.0109
Echinococcus multilocularis 0.017 0.0967 0.0964
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0045 0.0041
Schistosoma mansoni hypothetical protein 0.007 0.0359 0.0354
Echinococcus multilocularis muscleblind protein 1 0.0147 0.0824 0.0821
Brugia malayi bHLH-PAS transcription factor 0.0033 0.0135 0.0311
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0024 0.0078
Trypanosoma cruzi arginase, putative 0.0062 0.0309 0.1044
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.003 0.0114 0.0111
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0164 0.037
Trypanosoma cruzi Carboxypeptidase-like protein 0.0022 0.0066 0.022
Leishmania major arginase 0.017 0.0967 0.3279
Schistosoma mansoni hypothetical protein 0.0032 0.013 0.0125
Loa Loa (eye worm) hypothetical protein 0.0063 0.0312 0.0717
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0045 0.0149
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.0332 0.0327
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0012 0.0005 0.0011
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0091 0.021
Trypanosoma brucei antigen, putative 0.0019 0.0045 0.0149
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0496 0.2947 1
Trichomonas vaginalis set domain proteins, putative 0.0222 0.1281 0.295
Loa Loa (eye worm) calpain family protein 1 0.0063 0.0312 0.0717
Echinococcus granulosus mixed lineage leukemia protein mll 0.003 0.0114 0.0111
Loa Loa (eye worm) hypothetical protein 0.0022 0.0066 0.0149
Loa Loa (eye worm) calpain 0.0019 0.0045 0.0101
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0022 0.0066 0.0145
Echinococcus granulosus mitogen activated protein kinase 3 0.0022 0.0066 0.0062
Leishmania major basic transcription factor 3a, putative 0.0034 0.0141 0.0474
Loa Loa (eye worm) hypothetical protein 0.0026 0.0093 0.0211
Echinococcus multilocularis lamin dm0 0.0026 0.0091 0.0088
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.0024 0.0078
Brugia malayi hypoxia-induced factor 1 0.014 0.078 0.1799
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0092 0.0205
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0141 0.0318
Brugia malayi follicle stimulating hormone receptor 0.0242 0.1404 0.324
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0045 0.0149
Loa Loa (eye worm) hypothetical protein 0.0026 0.0091 0.0207
Loa Loa (eye worm) hypothetical protein 0.0147 0.0824 0.1899
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0496 0.2947 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0242 0.1404 0.3237
Echinococcus multilocularis mitogen activated protein kinase 3 0.0022 0.0066 0.0062
Echinococcus multilocularis subfamily M14A unassigned peptidase 0.0093 0.0497 0.0494
Brugia malayi hypothetical protein 0.0017 0.0036 0.0083
Echinococcus multilocularis mixed lineage leukemia protein mll 0.003 0.0114 0.0111
Onchocerca volvulus 0.0093 0.0497 0.1139
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.01 0.0539 0.1195
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0037 0.0157 0.0154
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0496 0.2947 0.6799
Schistosoma mansoni cpg binding protein 0.0116 0.0639 0.0635
Brugia malayi Zinc carboxypeptidase family protein 0.0022 0.0066 0.0153
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.013 0.0296
Echinococcus multilocularis calpain family protein 1, d 0.0044 0.0199 0.0196
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0019 0.0045 0.0149
Brugia malayi beta-NAC-like protein 0.0034 0.0141 0.0325
Echinococcus multilocularis hypothetical protein 0.0019 0.0045 0.0042
Trypanosoma brucei hypothetical protein, conserved 0.0055 0.0266 0.0898
Onchocerca volvulus 0.0026 0.0091 0.0202
Plasmodium vivax thioredoxin reductase, putative 0.0044 0.0198 0.063
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0017 0.0038 0.0075
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0022 0.0066 0.0218
Mycobacterium ulcerans putative regulatory protein 0.0033 0.0135 0.0308
Echinococcus granulosus calpain A 0.0019 0.0045 0.0042
Loa Loa (eye worm) hypothetical protein 0.0022 0.0066 0.0149
Echinococcus multilocularis calpain 7 (C02 family) 0.0019 0.0045 0.0042
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.0024 0.0038
Schistosoma mansoni protease m14 carboxypeptidase 0.0022 0.0066 0.0062
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0091 0.0207
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0164 0.0323
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0052 0.0113
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0093 0.0263
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0141 0.0474
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0092 0.0205
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0496 0.2947 0.6797
Loa Loa (eye worm) RecQ helicase 0.002 0.0052 0.0117
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0055 0.0266 0.0898
Trypanosoma brucei Enriched in surface-labeled proteome protein 12 0.0055 0.0266 0.0898
Trichomonas vaginalis carboxypeptidase regulatory region-containing protein, putative 0.0019 0.0051 0.0109
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0044 0.0198 0.0404
Trypanosoma cruzi zinc carboxypeptidase, putative 0.0022 0.0066 0.022
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.01 0.0539 0.8878
Echinococcus multilocularis GPCR, family 2 0.0032 0.013 0.0126
Echinococcus multilocularis mitogen activated protein kinase 0.0022 0.0066 0.0062
Schistosoma mansoni single-minded 0.0045 0.0206 0.0202
Trypanosoma brucei metallo-peptidase, Clan MC, Family M14, putative 0.0022 0.0066 0.022
Plasmodium falciparum thioredoxin reductase 0.0044 0.0198 0.0623
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0121 0.067 0.1497
Loa Loa (eye worm) zinc carboxypeptidase 0.0022 0.0066 0.0149
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0045 0.0149
Onchocerca volvulus Subfamily M14A unassigned peptidase homolog 0.0093 0.0497 0.1139
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0022 0.0066 0.0145
Echinococcus multilocularis musashi 0.0026 0.0091 0.0088
Leishmania major agmatinase-like protein 0.0062 0.0309 0.1044
Echinococcus granulosus calpain 0.0019 0.0045 0.0042
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0053 0.0255 0.0861
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0496 0.2947 0.6797
Loa Loa (eye worm) zinc carboxypeptidase 0.0022 0.0066 0.0149
Onchocerca volvulus Cytosolic carboxypeptidase 1 homolog 0.0022 0.0066 0.0145
Echinococcus granulosus mitogen activated protein kinase 0.0022 0.0066 0.0062
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0066 0.0061
Echinococcus granulosus lamin dm0 0.0026 0.0091 0.0088
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0052 0.0121
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0121 0.067 0.2269
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0015 0.0024 0.003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0483 0.0479
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.013 0.0126
Brugia malayi hypothetical protein 0.0113 0.0617 0.1424
Loa Loa (eye worm) hypothetical protein 0.0071 0.0363 0.0834
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0015 0.0024 1
Schistosoma mansoni hypothetical protein 0.0032 0.013 0.0125
Echinococcus granulosus transcription factor btf3 0.0034 0.0141 0.0138
Onchocerca volvulus Carboxypeptidase D homolog 0.0042 0.0185 0.0418
Trypanosoma brucei hypothetical protein, conserved 0.0055 0.0266 0.0898
Schistosoma mansoni ap endonuclease 0.0038 0.0164 0.0159
Echinococcus multilocularis neuropeptide s receptor 0.0452 0.2677 0.2675
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0022 0.0066 0.0145
Onchocerca volvulus 0.0093 0.0497 0.1139
Toxoplasma gondii thioredoxin reductase 0.0044 0.0198 0.0633
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0483 0.0478
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0006 0.0007
Trichomonas vaginalis CMGC family protein kinase 0.0022 0.0066 0.0144
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0164 0.055
Loa Loa (eye worm) hypothetical protein 0.0022 0.0066 0.0149
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0012 0.0005 0.0011
Schistosoma mansoni cpg binding protein 0.0123 0.0679 0.0675
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0496 0.2947 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0116 0.0264
Schistosoma mansoni calpain (C02 family) 0.0019 0.0045 0.0041
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0092 0.0205
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0483 0.0479
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0024 0.0056
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0015 0.0024 0.003
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0022 0.0066 0.0145
Plasmodium falciparum glutathione reductase 0.0015 0.0024 0.003
Onchocerca volvulus 0.0044 0.0199 0.0452
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0093 0.0271
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0111 0.0607 0.1352
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0027 0.0094 0.0091
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0045 0.0149
Echinococcus multilocularis calpain A 0.0066 0.0332 0.0328
Schistosoma mansoni arginase 0.017 0.0967 0.0964
Schistosoma mansoni transcription factor btf3 0.0034 0.0141 0.0137
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.067 0.1542
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0141 0.0322
Echinococcus multilocularis cytosolic carboxypeptidase protein 5 0.0022 0.0066 0.0063
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0164 0.037
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0141 0.0428
Loa Loa (eye worm) glutathione reductase 0.0044 0.0198 0.0454
Trypanosoma cruzi kinesin, putative 0.0019 0.0045 0.0149
Loa Loa (eye worm) hypothetical protein 0.0022 0.0066 0.0149
Loa Loa (eye worm) hypothetical protein 0.0712 0.4255 0.9815
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0053 0.0255 0.0251
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.004 0.0036
Trichomonas vaginalis hypothetical protein 0.0014 0.0018 0.0034
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.005 0.0233 0.0535
Leishmania major protein kinase, putative 0.0012 0.0005 0.0011
Echinococcus multilocularis transcription factor btf3 0.0034 0.0141 0.0138
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0024 0.0078
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0027 0.0023
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0045 0.0149
Trichomonas vaginalis CMGC family protein kinase 0.0022 0.0066 0.0144
Plasmodium vivax glutathione reductase, putative 0.0044 0.0198 0.063
Brugia malayi glutathione reductase 0.0044 0.0198 0.0458
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0091 0.0207
Toxoplasma gondii zinc carboxypeptidase superfamily protein 0.0022 0.0066 0.0183
Brugia malayi Carboxypeptidase A2 precursor 0.0022 0.0066 0.0153
Brugia malayi hypothetical protein 0.0712 0.4255 0.9816
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0024 0.0041
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0113
Trichomonas vaginalis CMGC family protein kinase 0.0022 0.0066 0.0144
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0012 0.0005 0.0011
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0024 0.0078
Loa Loa (eye worm) hypothetical protein 0.0042 0.0185 0.0422
Brugia malayi LD47325p 0.0019 0.0051 0.0117
Schistosoma mansoni aryl hydrocarbon receptor 0.0045 0.0206 0.0202
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0121 0.067 0.0667
Schistosoma mansoni metallocarboxypeptidase D peptidase unit 2 (M14 family) 0.0022 0.0066 0.0062
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0022 0.0066 0.0097
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0022 0.0066 0.0145
Trypanosoma cruzi ISWI complex protein 0.0012 0.0006 0.0017
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.067 0.0666
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0037 0.0157 0.0154
Loa Loa (eye worm) hypothetical protein 0.0026 0.0088 0.02
Loa Loa (eye worm) hypothetical protein 0.0022 0.0066 0.0149
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0725 0.4335 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0092 0.0205
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0255 0.0589
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0004 0.0001
Plasmodium falciparum arginase 0.017 0.0967 0.3247
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0015 0.0024 0.0053
Leishmania major hypothetical protein, conserved 0.0026 0.0093 0.031
Loa Loa (eye worm) zinc carboxypeptidase 0.0042 0.0185 0.0422
Brugia malayi Thioredoxin reductase 0.0044 0.0198 0.0458
Leishmania major protein kinase, putative 0.0012 0.0005 0.0011
Schistosoma mansoni Mername-AA248 (C02 family) 0.0019 0.0045 0.0041
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0483 0.1113
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0024 0.0078
Echinococcus granulosus 3'partial|arginase 2 mitochondrial 0.017 0.0967 0.0964
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0055 0.0266 0.0898
Leishmania major trypanothione reductase 0.0044 0.0198 0.0668
Onchocerca volvulus 0.0222 0.1281 0.295
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0195 0.1119 0.2579
Toxoplasma gondii zinc carboxypeptidase, putative 0.0022 0.0066 0.0183
Mycobacterium tuberculosis Putative ferredoxin reductase 0.01 0.0539 0.1195
Brugia malayi CXXC zinc finger family protein 0.0116 0.0639 0.1474
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0359 0.0827
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0024 0.0078
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0092 0.0205
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0092 0.0205
Brugia malayi F/Y-rich N-terminus family protein 0.0037 0.0154 0.0356
Echinococcus granulosus neuropeptide s receptor 0.0452 0.2677 0.2675
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0116 0.0111
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0496 0.2947 0.6798
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.003 0.0114 0.0111
Echinococcus granulosus arginase 2 mitochondrial 0.017 0.0967 0.0964
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0496 0.2947 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0164 0.0323
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1593 0.9611 0.9611
Onchocerca volvulus 0.003 0.0116 0.0259
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0045 0.0149
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0015 0.0024 0.0053
Loa Loa (eye worm) hypothetical protein 0.0016 0.0028 0.0061
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0003 0.0007
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.067 0.1542
Echinococcus multilocularis calpain 0.0019 0.0045 0.0042
Toxoplasma gondii aldehyde dehydrogenase 0.0121 0.067 0.224
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14, putative 0.0022 0.0066 0.022
Schistosoma mansoni intermediate filament proteins 0.0026 0.0091 0.0087
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0022 0.0066 0.022
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0164 0.016
Brugia malayi Zinc carboxypeptidase family protein 0.0042 0.0185 0.0426
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0121 0.067 0.0667
Schistosoma mansoni hypothetical protein 0.0022 0.0066 0.0062
Trypanosoma cruzi kinesin, putative 0.0019 0.0045 0.0149
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0022 0.0066 0.0218
Trypanosoma brucei kinesin, putative 0.0019 0.0045 0.0149
Leishmania major kinesin, putative 0.0019 0.0045 0.0149
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0022 0.0066 0.0145
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0045 0.0149
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0024 0.0078
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0024 0.0078
Brugia malayi calpain family protein 1 0.0063 0.0312 0.072
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0093 0.031
Echinococcus multilocularis bloom syndrome protein 0.002 0.0052 0.0049
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0725 0.4335 1
Trichomonas vaginalis conserved hypothetical protein 0.017 0.0967 0.2226
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.0024 0.0078
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0019 0.0045 0.0149
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0496 0.2947 1
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0022 0.0066 0.0145
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0093 0.0263
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.01 0.0539 0.1195
Loa Loa (eye worm) hypothetical protein 0.0022 0.0066 0.0149
Brugia malayi Pre-SET motif family protein 0.0195 0.1119 0.2582
Echinococcus multilocularis calpain 5 0.0019 0.0045 0.0042
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0483 0.111
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0725 0.4335 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0024 0.0078
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0164 0.0512
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0725 0.4335 1
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0045 0.0041
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0022 0.0066 0.022
Trypanosoma brucei metallo-peptidase, Clan MC, Family M14, putative 0.0022 0.0066 0.022
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0092 0.0205
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0006 0.0007
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0045 0.0149
Entamoeba histolytica Arginase, putative 0.017 0.0967 0.2204
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.0024 0.0078
Echinococcus multilocularis Zinc carboxypeptidase family protein 0.0022 0.0066 0.0063
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0066 0.018
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0092 0.0205
Onchocerca volvulus 0.0116 0.0639 0.1468
Echinococcus granulosus microtubule associated protein 2 0.0678 0.4053 0.4051
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0556 0.1279
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0116 0.0112
Schistosoma mansoni calpain C (C02 family) 0.0019 0.0045 0.0041
Plasmodium vivax arginase, putative 0.017 0.0967 0.3252
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0053 0.0255 0.0585
Schistosoma mansoni hypothetical protein 0.0675 0.4032 0.4029
Schistosoma mansoni hypothetical protein 0.0675 0.4032 0.4029
Schistosoma mansoni memapsin-2 (A01 family) 0.0152 0.0856 0.0853
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0116 0.0111
Echinococcus multilocularis lamin 0.0026 0.0091 0.0088
Schistosoma mansoni peptidase 0.0022 0.0066 0.0062
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0024 0.0041
Brugia malayi calpain family protein 1 0.0063 0.0312 0.072
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.001
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0015 0.0024 0.0053
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0024 0.0078
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0164 0.055
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0725 0.4335 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0024 0.0078
Loa Loa (eye worm) hypothetical protein 0.0044 0.0199 0.0456
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14 0.0022 0.0066 0.022
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0164 0.0377
Echinococcus granulosus calpain A 0.0066 0.0332 0.0328
Schistosoma mansoni cpg binding protein 0.0123 0.0679 0.0675
Brugia malayi MAP kinase sur-1 0.0022 0.0066 0.0152
Echinococcus granulosus calpain 7 C02 family 0.0019 0.0045 0.0042
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0164 1
Brugia malayi Zinc carboxypeptidase family protein 0.0022 0.0066 0.0153
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0055 0.0266 0.0898
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0496 0.2947 0.2945
Schistosoma mansoni hypothetical protein 0.0032 0.013 0.0125
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0022 0.0066 0.0181
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0248 0.1438 0.1434
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0045 0.0149
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0045 0.0149
Echinococcus multilocularis thioredoxin glutathione reductase 0.0044 0.0198 0.0195
Onchocerca volvulus 0.0022 0.0066 0.0145
Schistosoma mansoni lamin 0.0026 0.0091 0.0087
Onchocerca volvulus 0.0093 0.0497 0.1139
Onchocerca volvulus 0.0145 0.0814 0.1871
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0496 0.2947 1
Echinococcus granulosus calpain 5 0.0019 0.0045 0.0042
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0053 0.0255 0.0535
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0063 0.0312 0.0308
Loa Loa (eye worm) hypoxia-induced factor 1 0.014 0.078 0.1796
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0092 0.0205
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.01 0.0539 0.1195
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.013 0.0299
Brugia malayi Muscleblind-like protein 0.0147 0.0824 0.1902
Loa Loa (eye worm) hypothetical protein 0.0022 0.0066 0.0149
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0725 0.4335 1
Loa Loa (eye worm) zinc carboxypeptidase 0.0022 0.0066 0.0149
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0116 0.0111
Schistosoma mansoni survival motor neuron protein 0.0145 0.0814 0.081
Schistosoma mansoni microtubule-associated protein tau 0.0678 0.4053 0.4051
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0092 0.0205
Loa Loa (eye worm) hypothetical protein 0.0147 0.0824 0.1899
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0483 0.0478
Brugia malayi hypothetical protein 0.0026 0.0093 0.0214
Echinococcus granulosus lamin 0.0026 0.0091 0.0088
Mycobacterium tuberculosis Probable dehydrogenase 0.01 0.0539 0.1195
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0003 0.0007
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0111 0.0607 1
Brugia malayi Latrophilin receptor protein 2 0.0032 0.013 0.0299
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0145 0.0814 0.1878
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0053 0.0255 0.0252
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0092 0.0205
Loa Loa (eye worm) hypothetical protein 0.0044 0.0199 0.0456
Plasmodium falciparum glutathione reductase 0.0044 0.0198 0.0623
Trypanosoma cruzi arginase, putative 0.0062 0.0309 0.1044
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0141 0.0435
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0141 0.0318
Brugia malayi Cytochrome P450 family protein 0.0011 0.0001 0.0003
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0009 0.0005
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0725 0.4335 1
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0066 0.0332 0.0328
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.0024 0.0038
Entamoeba histolytica protein kinase, putative 0.0019 0.0047 0.0071
Toxoplasma gondii flagellar/basal body protein 0.0022 0.0066 0.0183
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0141 0.0318
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14, putative 0.0022 0.0066 0.022
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0045 0.0149
Schistosoma mansoni myst-related protein 0.0014 0.0016 0.0011
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.013 0.0126
Schistosoma mansoni hypothetical protein 0.0145 0.0814 0.081
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0045 0.0149
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0725 0.4335 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0018 0.0034
Schistosoma mansoni lamin 0.0026 0.0091 0.0087
Trypanosoma cruzi agmatinase, putative 0.0062 0.0309 0.1044
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0017 0.004
Schistosoma mansoni family M14 non-peptidase homologue (M14 family) 0.0022 0.0066 0.0062
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0053 0.0255 0.0585
Trypanosoma brucei ISWI complex protein 0.0012 0.0006 0.0017
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0022 0.0066 0.0218
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0022 0.0066 0.0218
Brugia malayi calpain 7 0.0019 0.0045 0.0105
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0012 0.0005 0.0011
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0055 0.0266 0.0898
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.0332 0.0327
Toxoplasma gondii histone lysine methyltransferase SET1 0.0221 0.1278 0.4311
Trichomonas vaginalis conserved hypothetical protein 0.017 0.0967 0.2226
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0116 0.0112
Loa Loa (eye worm) hypothetical protein 0.0103 0.0556 0.1279
Echinococcus granulosus single minded 2 0.0033 0.0135 0.0132
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0024 0.0049
Echinococcus multilocularis microtubule associated protein 2 0.0678 0.4053 0.4051
Echinococcus multilocularis 0.0022 0.0066 0.0063
Loa Loa (eye worm) histone methyltransferase 0.0037 0.0157 0.0359
Giardia lamblia Kinase, CMGC MAPK 0.0022 0.0066 0.0096
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0066 0.0332 0.0328
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0092 0.0205
Schistosoma mansoni hypothetical protein 0.1657 1 1
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0022 0.0066 0.0097
Trypanosoma brucei trypanothione reductase 0.0044 0.0198 0.0668
Brugia malayi Zinc carboxypeptidase family protein 0.0022 0.0066 0.0153
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0024 0.0021
Echinococcus granulosus muscleblind protein 0.0147 0.0824 0.0821
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0022 0.0066 0.0145
Echinococcus granulosus neuropeptide receptor A26 0.0452 0.2677 0.2675
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0164 0.0342
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0725 0.4335 1
Brugia malayi Cytochrome P450 family protein 0.0011 0.0001 0.0003
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.013 0.0126
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0093 0.0274
Echinococcus granulosus geminin 0.0675 0.4032 0.403
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0024 0.002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0483 0.0479
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0045 0.0149
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0164 0.0374
Entamoeba histolytica hypothetical protein 0.0034 0.0141 0.029
Brugia malayi Pre-SET motif family protein 0.003 0.0116 0.0267
Loa Loa (eye worm) calpain family protein 1 0.0044 0.0199 0.0456
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0024 0.0078
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0496 0.2947 0.6798
Brugia malayi hypothetical protein 0.0151 0.0851 0.1963
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0092 0.0205
Loa Loa (eye worm) hypothetical protein 0.0063 0.0312 0.0717
Echinococcus multilocularis transfer RNA-Lys 0.0033 0.0135 0.0132
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0164 0.055
Trichomonas vaginalis Arginase, putative 0.017 0.0967 0.2226
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0141 0.0474
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0055 0.0266 0.0898
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0045 0.0149
Trypanosoma brucei protein kinase, putative 0.0022 0.0066 0.0218
Brugia malayi PAS domain containing protein 0.0045 0.0206 0.0475
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0012 0.0003 0.0004
Mycobacterium tuberculosis Probable reductase 0.01 0.0539 0.1195
Schistosoma mansoni subfamily M14A unassigned peptidase (M14 family) 0.0093 0.0497 0.0493
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0092 0.0205
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0024 0.0078
Echinococcus granulosus thioredoxin glutathione reductase 0.0044 0.0198 0.0195
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0164 0.016
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0496 0.2947 0.6799
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0093 0.031
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0141 0.029
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0483 0.0479
Echinococcus granulosus cytosolic carboxypeptidase 1 0.0022 0.0066 0.0063
Mycobacterium tuberculosis Probable oxidoreductase 0.0111 0.0607 0.1352
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0496 0.2947 0.6788
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0022 0.0066 0.0145
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0045 0.0149
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0725 0.4335 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0725 0.4335 1
Echinococcus multilocularis cpg binding protein 0.0123 0.0679 0.0676
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.067 0.1542
Echinococcus multilocularis muscleblind protein 0.0147 0.0824 0.0821
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0053 0.0255 0.0252
Brugia malayi Zinc carboxypeptidase family protein 0.0022 0.0066 0.0153
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0725 0.4335 1
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0141 0.0474
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.0198 0.0668
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0022 0.0066 0.0148
Toxoplasma gondii exonuclease III APE 0.0038 0.0164 0.0515
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0092 0.0205
Loa Loa (eye worm) hypothetical protein 0.0012 0.0006 0.001
Brugia malayi Zinc carboxypeptidase family protein 0.0022 0.0066 0.0153
Plasmodium vivax SET domain protein, putative 0.003 0.0116 0.0349
Schistosoma mansoni hypothetical protein 0.0032 0.013 0.0125
Echinococcus multilocularis dnaJ subfamily B 0.1657 1 1
Loa Loa (eye worm) hypothetical protein 0.0294 0.1718 0.3961
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0022 0.0066 0.0218
Echinococcus granulosus bloom syndrome protein 0.002 0.0052 0.0049
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0024 0.0078
Loa Loa (eye worm) hypothetical protein 0.0151 0.0851 0.196
Loa Loa (eye worm) CXXC zinc finger family protein 0.0116 0.0639 0.1472
Echinococcus granulosus subfamily M14A unassigned peptidase 0.0093 0.0497 0.0494
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0022 0.0066 0.0145
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0022 0.0066 0.0218
Onchocerca volvulus 0.0026 0.0091 0.0202
Brugia malayi intermediate filament protein 0.0026 0.0091 0.021
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0024 0.0078
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.013 0.0126
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0556 0.1282
Echinococcus granulosus survival motor neuron protein 1 0.0712 0.4255 0.4253
Echinococcus multilocularis neuropeptide receptor A26 0.0452 0.2677 0.2675
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.0296
Entamoeba histolytica calpain large subunit domain III containing protein 0.0019 0.0045 0.0069
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0725 0.4335 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0017 0.0037
Schistosoma mansoni peptidase 0.0022 0.0066 0.0062
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0022 0.0066 0.0097
Echinococcus granulosus Zinc carboxypeptidase family protein 0.0022 0.0066 0.0063
Schistosoma mansoni mixed-lineage leukemia protein mll 0.003 0.0114 0.011
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0116 0.0111
Trichomonas vaginalis CMGC family protein kinase 0.0022 0.0066 0.0144
Loa Loa (eye worm) hypothetical protein 0.0022 0.0066 0.0149
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0003 0.0007
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0018 0.0034
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0093 0.031
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0009 0.0005
Schistosoma mansoni ap endonuclease 0.0038 0.0164 0.0159
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0004 0.0001
Brugia malayi Zinc carboxypeptidase family protein 0.0042 0.0185 0.0426
Toxoplasma gondii zinc carboxypeptidase superfamily protein 0.0022 0.0066 0.0183
Echinococcus granulosus cytosolic carboxypeptidase protein 5 0.0022 0.0066 0.0063
Schistosoma mansoni carboxypeptidase N (M14 family) 0.0022 0.0066 0.0062
Echinococcus multilocularis arginase 2, mitochondrial 0.017 0.0967 0.0964
Loa Loa (eye worm) hypothetical protein 0.0013 0.0009 0.0017
Onchocerca volvulus 0.0093 0.0497 0.1139
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0556 0.1282
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.067 0.0666
Echinococcus granulosus cpg binding protein 0.0123 0.0679 0.0676
Echinococcus granulosus intermediate filament protein 0.0026 0.0091 0.0088
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0496 0.2947 1
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0496 0.2947 0.2945
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0052 0.0113
Plasmodium falciparum thioredoxin reductase 0.0015 0.0024 0.003
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0164 0.055
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0024 0.0049

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 195 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays: 2118 (Project Summary), 2098 (Primary HTS)] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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