Detailed information for compound 1294188

Basic information

Technical information
  • TDR Targets ID: 1294188
  • Name: 4-[[(Z)-[1-(3-methylphenyl)-2,4,6-trioxo-1,3- diazinan-5-ylidene]methyl]amino]benzenesulfon amide
  • MW: 400.408 | Formula: C18H16N4O5S
  • H donors: 3 H acceptors: 5 LogP: 1.33 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(c1)N1C(=O)NC(=O)/C(=C/Nc2ccc(cc2)S(=O)(=O)N)/C1=O
  • InChi: 1S/C18H16N4O5S/c1-11-3-2-4-13(9-11)22-17(24)15(16(23)21-18(22)25)10-20-12-5-7-14(8-6-12)28(19,26)27/h2-10,20H,1H3,(H2,19,26,27)(H,21,23,25)/b15-10-
  • InChiKey: NIJGYMNCBQYNEW-GDNBJRDFSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[[(Z)-[1-(3-methylphenyl)-2,4,6-trioxo-hexahydropyrimidin-5-ylidene]methyl]amino]benzenesulfonamide
  • 4-[[(Z)-[1-(3-methylphenyl)-2,4,6-trioxo-5-hexahydropyrimidinylidene]methyl]amino]benzenesulfonamide
  • 4-[[(Z)-[2,4,6-triketo-1-(3-methylphenyl)hexahydropyrimidin-5-ylidene]methyl]amino]benzenesulfonamide
  • ZINC04797347
  • MLS000703436
  • SMR000273900
  • BAS 00620721

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Aberrant vpr protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0017 0.023
Toxoplasma gondii aldehyde dehydrogenase 0.0187 0.0499 1
Leishmania major ubiquitin-activating enzyme-like protein 0.0032 0.0037 0.0738
Schistosoma mansoni ubiquitin-conjugating enzyme E2 I 0.0025 0.0017 0.0156
Trypanosoma cruzi hexokinase, putative 0.0079 0.0179 0.6751
Brugia malayi Bromodomain containing protein 0.0038 0.0056 0.0748
Plasmodium falciparum JmjC domain-containing protein, putative 0.0025 0.0017 0.0025
Trypanosoma brucei hexokinase 0.0079 0.0179 0.6751
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0025 0.0017 0.0159
Brugia malayi jmjC domain containing protein 0.0025 0.0017 0.023
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0032 0.0037 0.0738
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0061 0.0125 0.2509
Onchocerca volvulus 0.005 0.0091 0.0998
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0023 0.0864
Brugia malayi Hexokinase family protein 0.0025 0.0016 0.021
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0029 0.0268
Trichomonas vaginalis ubiquitin-conjugating enzyme rad6, putative 0.0025 0.0017 0.0225
Plasmodium falciparum phd finger protein, putative 0.0029 0.0029 0.0758
Echinococcus granulosus JmjC domain containing protein 4 0.0025 0.0017 0.0348
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0048 0.0086 0.1719
Loa Loa (eye worm) ube2i2 protein 0.0025 0.0017 0.0225
Loa Loa (eye worm) hypothetical protein 0.007 0.0153 0.2024
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0385 0.109 1
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0025 0.0017 0.0009
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0032 0.0037 0.0738
Trichomonas vaginalis set domain proteins, putative 0.0237 0.0648 0.8598
Brugia malayi hexokinase type II 0.0025 0.0018 0.0237
Schistosoma mansoni Replicative DNA helicase 0.0385 0.109 1
Mycobacterium leprae Conserved hypothetical protein 0.1135 0.3324 1
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0385 0.109 0.2975
Echinococcus granulosus jumonji domain containing 1A 0.0025 0.0017 0.0348
Mycobacterium ulcerans recombinase A 0.0107 0.0263 0.2413
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.003 1
Brugia malayi ube2i2 protein 0.0025 0.0017 0.0225
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0049 0.0989
Brugia malayi jmjC domain containing protein 0.0154 0.0401 0.5322
Mycobacterium tuberculosis Conserved hypothetical protein 0.0867 0.2526 0.2526
Mycobacterium ulcerans aldehyde dehydrogenase 0.0187 0.0499 0.4581
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.0265 0.0383
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.0265 0.5315
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0265 0.3519
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0385 0.109 1
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.0265 0.5315
Echinococcus granulosus hexokinase type 2 0.0079 0.0179 0.3588
Schistosoma mansoni phosphatidylserine receptor 0.0025 0.0017 0.0159
Loa Loa (eye worm) hexokinase 0.0079 0.0179 0.2375
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.003 0.0268
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0027 0.0023 0.0462
Brugia malayi Bromodomain containing protein 0.0031 0.0036 0.0481
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0154 0.0401 0.8039
Entamoeba histolytica acetyltransferase, putative 0.007 0.0151 0.5707
Echinococcus multilocularis zinc finger protein 0.0019 0.0001 0.0017
Loa Loa (eye worm) twinkle helicase 0.011 0.027 0.3586
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0025 0.0017 0.0009
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0023 0.0368
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0025 0.0017 0.0639
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0113 0.1498
Echinococcus granulosus lysine specific demethylase 5A 0.0096 0.0228 0.4574
Treponema pallidum recombinase A 0.0107 0.0263 0.22
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.0265 0.2222
Schistosoma mansoni protein phosphatase 2C 0.0025 0.0017 0.0159
Chlamydia trachomatis replicative DNA helicase 0.0385 0.109 1
Echinococcus granulosus lysine specific demethylase 6a 0.0025 0.0017 0.0348
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0082 0.0755
Schistosoma mansoni hypothetical protein 0.0021 0.0004 0.0036
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0265 1
Brugia malayi 6-phosphofructokinase 0.0108 0.0265 0.3519
Loa Loa (eye worm) jmjC domain-containing protein 0.0096 0.0228 0.3028
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0078 0.1572
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0265 0.3519
Mycobacterium ulcerans aldehyde dehydrogenase 0.0187 0.0499 0.4581
Leishmania major hypothetical protein, conserved 0.0027 0.0023 0.0459
Schistosoma mansoni jumonji/arid domain-containing protein 0.0096 0.0228 0.2095
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0265 0.2435
Echinococcus granulosus ubiquitin conjugating enzyme e2 i 0.0025 0.0017 0.034
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0032 0.0037 0.1389
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0027 0.0024 0.0894
Loa Loa (eye worm) hypothetical protein 0.0042 0.0069 0.0919
Brugia malayi Pre-SET motif family protein 0.0208 0.0563 0.7462
Echinococcus granulosus dynactin 5 p25 0.007 0.0151 0.3033
Echinococcus granulosus hexokinase 0.0079 0.0179 0.3588
Loa Loa (eye worm) hexokinase type II 0.0079 0.0179 0.2375
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0078 0.072
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0017 0.0655
Brugia malayi phosphofructokinase 0.0108 0.0265 0.3519
Plasmodium vivax JmjC domain containing protein 0.0025 0.0017 0.0025
Schistosoma mansoni jumonji domain containing protein 0.0134 0.0343 0.3148
Loa Loa (eye worm) hypothetical protein 0.0047 0.0082 0.1091
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0025 0.0017 0.0639
Mycobacterium ulcerans transferase 0.0067 0.0143 0.1317
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0265 1
Trypanosoma brucei hexokinase 0.0079 0.0179 0.6751
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0017 0.0655
Onchocerca volvulus 0.0237 0.0648 1
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.003 0.0268
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.003 0.0396
Treponema pallidum replicative DNA helicase (dnaB) 0.0385 0.109 1
Echinococcus multilocularis lysine specific demethylase 6a 0.0025 0.0017 0.0348
Onchocerca volvulus 0.003 0.0032 0.0039
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0265 1
Brugia malayi hypothetical protein 0.0027 0.0023 0.0304
Schistosoma mansoni zinc finger protein 0.0019 0.0001 0.0008
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0048 0.0086 0.4245
Trichomonas vaginalis glutaminase, putative 0.0272 0.0754 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0029 0.0255
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0078 0.072
Onchocerca volvulus 0.0079 0.0179 0.2421
Loa Loa (eye worm) hypothetical protein 0.0048 0.0086 0.1138
Loa Loa (eye worm) hypothetical protein 0.0025 0.0017 0.023
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0082 0.1648
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.003 0.0797
Brugia malayi Hexokinase family protein 0.0079 0.0179 0.2375
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0265 0.3519
Leishmania major hexokinase, putative 0.0079 0.0179 0.3588
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0078 0.1572
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0078 0.1041
Giardia lamblia PHD finger protein 15 0.0029 0.0029 0.979
Echinococcus multilocularis phd:f box containing protein 0.0025 0.0017 0.0348
Giardia lamblia UBC3 0.0025 0.0017 0.5677
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0032 0.029
Onchocerca volvulus 0.0079 0.0179 0.2421
Schistosoma mansoni hexokinase 0.0079 0.0179 0.1644
Loa Loa (eye worm) hexokinase 0.0025 0.0016 0.021
Brugia malayi hexokinase 0.0079 0.0179 0.2375
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.003 0.0396
Brugia malayi Hexokinase family protein 0.005 0.0091 0.1207
Schistosoma mansoni phd/f-box containing protein 0.0025 0.0017 0.0159
Trypanosoma cruzi hexokinase, putative 0.0079 0.0179 0.6751
Echinococcus granulosus hexokinase 0.0079 0.0179 0.3588
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0044 0.0073 0.0667
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0078 0.1572
Echinococcus multilocularis hexokinase 0.0079 0.0179 0.3588
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0265 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.003 0.0396
Echinococcus multilocularis hexokinase 0.0079 0.0179 0.3588
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0187 0.0499 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0029 0.0586
Entamoeba histolytica ankyrin, putative 0.007 0.0151 0.5707
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0121 0.161
Brugia malayi ThiF family protein 0.0048 0.0086 0.1138
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.003 0.0268
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0025 0.0017 0.034
Loa Loa (eye worm) glutaminase 0.0272 0.0754 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.0563 0.7462
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0017 0.023
Schistosoma mansoni aldehyde dehydrogenase 0.0187 0.0499 0.4581
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.0265 0.0265
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0048 0.0086 0.1719
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0023 0.0124
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0029 0.0255
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0032 0.029
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0265 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0027 0.0023 0.0462
Trypanosoma cruzi DNA repair protein, putative 0.0033 0.0041 0.1557
Trypanosoma cruzi DNA repair protein, putative 0.0033 0.0041 0.1557
Schistosoma mansoni aldehyde dehydrogenase 0.0187 0.0499 0.4581
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0028 0.0568
Brugia malayi jmjC domain containing protein 0.0025 0.0017 0.023
Loa Loa (eye worm) hexokinase 0.0079 0.0179 0.2375
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0061 0.0125 0.1661
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.001 0.0193
Loa Loa (eye worm) hypothetical protein 0.0027 0.0023 0.0304
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.001 0.0088
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0032 0.0037 0.1389
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.003 0.0797
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0061 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0041 0.0064 0.0844
Chlamydia trachomatis recombinase RecA 0.0107 0.0263 0.22
Loa Loa (eye worm) ThiF family protein 0.0032 0.0037 0.0489
Echinococcus multilocularis hexokinase 0.0079 0.0179 0.3588
Treponema pallidum hexokinase (hxk) 0.0079 0.0179 0.1408
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0025 0.0017 0.0639
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0029 0.0586
Mycobacterium tuberculosis Probable serine acetyltransferase CysE (sat) 0.007 0.0151 0.0151
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0107 0.0263 0.0376
Loa Loa (eye worm) phosphofructokinase 0.0108 0.0265 0.3519
Echinococcus multilocularis hexokinase type 2 0.0079 0.0179 0.3588
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.003 0.0797
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.0125 0.2509
Leishmania major hypothetical protein, conserved 0.0025 0.0017 0.0348
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0125 0.115
Plasmodium falciparum hexokinase 0.0079 0.0179 1
Echinococcus granulosus zinc finger protein 0.0019 0.0001 0.0017
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.012 0.2402
Echinococcus multilocularis lysine specific demethylase 5A 0.0094 0.0223 0.446
Toxoplasma gondii hexokinase 0.0079 0.0179 0.3363
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0025 0.0017 0.0655
Echinococcus multilocularis ubiquitin conjugating enzyme e2 i 0.0025 0.0017 0.034
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.012 0.2402
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0049 0.0989
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.003 0.0396
Echinococcus multilocularis JmjC domain containing protein 4 0.0025 0.0017 0.0348
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0048 0.0086 0.0787
Schistosoma mansoni jumonji/arid domain-containing protein 0.0096 0.0228 0.2095
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.003 0.0396
Toxoplasma gondii hypothetical protein 0.0048 0.0086 0.1427
Onchocerca volvulus Hexokinase homolog 0.005 0.0091 0.0998
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0063 0.1265
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0032 0.0634
Brugia malayi jmjC domain containing protein 0.0025 0.0017 0.023
Loa Loa (eye worm) hypothetical protein 0.0038 0.0057 0.0751
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.3098 0.9173 0.9173
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0023 0.0864
Trypanosoma brucei ubiquitin-conjugating enzyme E2, putative 0.0025 0.0017 0.0639
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0187 0.0499 0.0499
Echinococcus multilocularis jumonji domain containing 1A 0.0025 0.0017 0.0348
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0004 0.0053
Brugia malayi jmjC domain containing protein 0.0096 0.0228 0.3028
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0265 0.3519
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0187 0.0499 1
Toxoplasma gondii ThiF family protein 0.0032 0.0037 0.0413
Plasmodium vivax hexokinase, putative 0.0079 0.0179 1
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0029 0.0758
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0082 0.1648
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0078 0.1041
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0023 0.0368
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0023 0.0368
Onchocerca volvulus 0.0079 0.0179 0.2421
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.003 0.1126
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.0265 0.5315
Schistosoma mansoni hypothetical protein 0.0029 0.0029 0.0268
Entamoeba histolytica hexokinase 2 0.0079 0.0179 0.6751
Schistosoma mansoni jumonji domain containing protein 0.0025 0.0017 0.0159
Brugia malayi Bromodomain containing protein 0.0075 0.0165 0.2192
Echinococcus granulosus phd:f box containing protein 0.0025 0.0017 0.0348
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0078 0.072
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0265 0.2435
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0061 0.0125 0.115
Onchocerca volvulus 0.0067 0.0143 0.1845
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0032 0.0037 0.1227
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0187 0.0499 1
Brugia malayi PHD-finger family protein 0.0029 0.0029 0.0388
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.0265 0.2435
Loa Loa (eye worm) hypothetical protein 0.0025 0.0017 0.023
Brugia malayi ThiF family protein 0.0032 0.0037 0.0489
Echinococcus granulosus hexokinase 0.0079 0.0179 0.3588
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0082 0.0755
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0023 0.0864
Leishmania major hexokinase, putative 0.0079 0.0179 0.3588
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0017 0.023
Trichomonas vaginalis maltose O-acetyltransferase, putative 0.0067 0.0143 0.1903
Loa Loa (eye worm) hypothetical protein 0.0025 0.0018 0.0237
Echinococcus multilocularis peregrin 0.0031 0.0036 0.0727
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0033 0.0041 0.1557
Brugia malayi PHD-finger family protein 0.0025 0.0017 0.0221
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.003 0.0396
Plasmodium vivax SET domain protein, putative 0.003 0.0032 0.0906
Brugia malayi Pre-SET motif family protein 0.003 0.0032 0.042
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0265 0.3519
Loa Loa (eye worm) hypothetical protein 0.0065 0.0138 0.1827
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0388
Echinococcus granulosus peregrin 0.0031 0.0036 0.0727
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.003 0.0797
Schistosoma mansoni glutaminase 0.0272 0.0754 0.692
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0107 0.0263 0.1189
Brugia malayi jmjC domain containing protein 0.0025 0.0017 0.023
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0154 0.0401 0.8039
Schistosoma mansoni bromodomain containing protein 0.0063 0.0131 0.1198
Entamoeba histolytica hexokinase 1 0.0079 0.0179 0.6751
Loa Loa (eye worm) glutaminase 2 0.0272 0.0754 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0187 0.0499 0.4581
Trypanosoma brucei hexokinase, putative 0.0079 0.0179 0.6751
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0029 0.0388
Brugia malayi glutaminase DH11.1 0.0272 0.0754 1
Loa Loa (eye worm) hexokinase 0.005 0.0091 0.1207
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0032 0.0305
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0032 0.0037 0.1227
Brugia malayi 6-phosphofructokinase 0.0108 0.0265 0.3519
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.0125 0.2509
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.001 0.0193
Loa Loa (eye worm) hypothetical protein 0.0054 0.0104 0.1379
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0265 0.3519
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0143 0.1903
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0078 0.1572
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0032 0.0037 0.0338
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0125 0.115
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.003 0.0396
Mycobacterium ulcerans glutaminase 0.0272 0.0754 0.692
Plasmodium vivax ubiquitin activating enzyme, putative 0.0048 0.0086 0.4245
Loa Loa (eye worm) hypothetical protein 0.0025 0.0018 0.0237
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0025 0.0017 0.0639
Echinococcus granulosus jumonji domain containing protein 0.004 0.0063 0.1265

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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