Detailed information for compound 1301739

Basic information

Technical information
  • TDR Targets ID: 1301739
  • Name: [2-(1-adamantyl)-2-oxoethyl] 2-[(2-chloro-4-n itrobenzoyl)amino]-4-methylsulfanylbutanoate
  • MW: 509.015 | Formula: C24H29ClN2O6S
  • H donors: 1 H acceptors: 5 LogP: 4.95 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: CSCCC(C(=O)OCC(=O)C12CC3CC(C2)CC(C1)C3)NC(=O)c1ccc(cc1Cl)[N+](=O)[O-]
  • InChi: 1S/C24H29ClN2O6S/c1-34-5-4-20(26-22(29)18-3-2-17(27(31)32)9-19(18)25)23(30)33-13-21(28)24-10-14-6-15(11-24)8-16(7-14)12-24/h2-3,9,14-16,20H,4-8,10-13H2,1H3,(H,26,29)
  • InChiKey: FAVRMHZHOQIBIC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-(1-adamantyl)-2-oxo-ethyl] 2-[(2-chloro-4-nitro-benzoyl)amino]-4-methylsulfanyl-butanoate
  • 2-[[(2-chloro-4-nitrophenyl)-oxomethyl]amino]-4-(methylthio)butanoic acid [2-(1-adamantyl)-2-oxoethyl] ester
  • 2-[(2-chloro-4-nitro-benzoyl)amino]-4-(methylthio)butyric acid [2-(1-adamantyl)-2-keto-ethyl] ester
  • [2-(1-adamantyl)-2-oxo-ethyl] 2-[(2-chloro-4-nitro-phenyl)carbonylamino]-4-methylsulfanyl-butanoate
  • MLS000334400
  • SMR000249158
  • T5284705

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major flap endonuclease-1 (FEN-1), putative 0.003 0.0092 0.0384
Loa Loa (eye worm) glutaminase 2 0.0291 0.2365 0.7826
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0042 0.0202 0.0198
Echinococcus multilocularis neuropeptides capa receptor 0.0042 0.0202 0.0198
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0221 0.1753 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0171 0.0705
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Echinococcus multilocularis neuropeptide receptor 0.0042 0.0202 0.0198
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0202 0.0198
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0202 0.0198
Brugia malayi Dopamine receptor 0.0042 0.0202 0.0667
Echinococcus multilocularis allatostatin A receptor 0.0042 0.0202 0.0198
Brugia malayi AMP-binding enzyme family protein 0.0055 0.0311 0.1029
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0102 0.0116
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0471 0.0467
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0471 0.1978
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.003 0.0092 0.0384
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0102 0.0336
Echinococcus multilocularis orexin receptor type 2 0.0042 0.0202 0.0198
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0156 0.0366
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0644 0.0732
Onchocerca volvulus 0.0058 0.0337 0.1084
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0202 0.0198
Echinococcus granulosus fmrfamide receptor 0.0042 0.0202 0.0198
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0098 0.0137
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.003 0.0093 0.0387
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0217 0.09
Trypanosoma brucei hypothetical protein, conserved 0.0078 0.051 0.2802
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0026 0.003
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0102 0.0097
Loa Loa (eye worm) fibroinase 0.0058 0.0337 0.1116
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0042 0.0202 0.0229
Echinococcus granulosus orexin receptor type 2 0.0042 0.0202 0.0198
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Schistosoma mansoni hypothetical protein 0.0042 0.0203 0.0231
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0202 0.0229
Brugia malayi Serotonin receptor 0.0042 0.0202 0.0667
Echinococcus multilocularis flap endonuclease 1 0.003 0.0092 0.0088
Echinococcus granulosus cathepsin l1 0.0058 0.0337 0.0333
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0367 0.3022 0.3019
Loa Loa (eye worm) hypothetical protein 0.0078 0.051 0.1687
Schistosoma mansoni flap endonuclease-1 0.0027 0.0068 0.0077
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0644 0.064
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0026 0.0149
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0078 0.051 0.2142
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Loa Loa (eye worm) G-protein coupled receptor 0.0042 0.0202 0.0667
Leishmania major cysteine peptidase A (CPA) 0.0058 0.0337 0.1802
Loa Loa (eye worm) hypothetical protein 0.0031 0.0102 0.0336
Schistosoma mansoni hypothetical protein 0.0042 0.0202 0.0229
Echinococcus multilocularis g-protein coupled receptor 0.0042 0.0202 0.0198
Schistosoma mansoni hypothetical protein 0.0102 0.0723 0.0822
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0221 0.1753 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0102 0.0336
Brugia malayi beta-lactamase 0.0078 0.051 0.1687
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0042 0.0202 0.0198
Brugia malayi hypothetical protein 0.0042 0.0202 0.0667
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Brugia malayi Cathepsin L-like precursor 0.0058 0.0337 0.1116
Schistosoma mansoni hypothetical protein 0.0042 0.0203 0.0231
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0217 0.0213
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0337 0.1411
Brugia malayi hypothetical protein 0.0042 0.0202 0.0667
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0102 0.0336
Brugia malayi putative neuropeptide receptor 0.0042 0.0202 0.0667
Echinococcus granulosus G protein coupled receptor 139 0.0042 0.0202 0.0198
Onchocerca volvulus 0.0042 0.0202 0.0461
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.003 0.0093 0.0387
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0042 0.0202 0.0667
Entamoeba histolytica acyl-coA synthetase, putative 0.0055 0.0311 0.4068
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Echinococcus multilocularis somatostatin receptor 0.0042 0.0202 0.0198
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0026 0.0093
Echinococcus granulosus geminin 0.103 0.8794 0.8794
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0102 0.0097
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0102 0.0097
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0202 0.0198
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0026 0.0053
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0042 0.0202 0.0198
Loa Loa (eye worm) hypothetical protein 0.0078 0.051 0.1687
Loa Loa (eye worm) flap endonuclease-1 0.003 0.0092 0.0306
Entamoeba histolytica cysteine protease, putative 0.003 0.0093 0.0955
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0141 0.0161
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0202 0.1586 0.905
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0058 0.0337 0.1411
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0102 0.0097
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.051 0.2142
Leishmania major cathepsin L-like protease 0.0058 0.0337 0.1802
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0202 0.0198
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0042 0.0202 0.0667
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0055 0.0311 0.474
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0202 0.0229
Schistosoma mansoni hypothetical protein 0.0042 0.0203 0.0231
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0102 0.0097
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0042 0.0202 0.0198
Schistosoma mansoni neuropeptide receptor 0.0042 0.0202 0.0229
Brugia malayi hypothetical protein 0.0089 0.0611 0.2023
Entamoeba histolytica cysteine proteinase 2 0.003 0.0093 0.0955
Loa Loa (eye worm) hypothetical protein 0.0102 0.0723 0.2392
Brugia malayi hypothetical protein 0.027 0.2185 0.7231
Plasmodium falciparum cysteine proteinase falcipain 1 0.003 0.0093 0.0021
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.015 0.1135 0.3754
Entamoeba histolytica hypothetical protein 0.0042 0.0199 0.247
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0102 0.0097
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0042 0.0202 0.0198
Brugia malayi Melatonin receptor type 1A 0.0042 0.0202 0.0667
Leishmania major cathepsin L-like protease 0.0058 0.0337 0.1802
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0202 0.0229
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.051 0.2142
Trichomonas vaginalis set domain proteins, putative 0.0281 0.2275 0.9619
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0093 0.0955
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Brugia malayi Pre-SET motif family protein 0.0247 0.1979 0.6547
Schistosoma mansoni hypothetical protein 0.0055 0.0313 0.0356
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0102 0.0336
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Schistosoma mansoni ferritin 0.002 0.0004 0.0005
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.051 0.2142
Brugia malayi Cathepsin L-like precursor 0.0058 0.0337 0.1116
Echinococcus granulosus cathepsin L cysteine proteinase 0.0058 0.0337 0.0333
Entamoeba histolytica cysteine protease, putative 0.003 0.0093 0.0955
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0202 0.0229
Echinococcus multilocularis Niemann Pick C1 protein 0.0147 0.111 0.1106
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0337 0.1411
Loa Loa (eye worm) hypothetical protein 0.0089 0.0611 0.2023
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0102 0.0116
Onchocerca volvulus 0.0042 0.0202 0.0461
Schistosoma mansoni neuropeptide receptor 0.0042 0.0202 0.0229
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0102 0.0336
Onchocerca volvulus 0.0042 0.0202 0.0461
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0102 0.0336
Schistosoma mansoni apoferritin-2 0.002 0.0004 0.0005
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0055 0.0311 0.1299
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0644 0.0732
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0042 0.0202 0.0198
Schistosoma mansoni ferritin light chain 0.002 0.0004 0.0005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0337 0.1411
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0202 0.0198
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.002 0.0004 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0202 0.0229
Entamoeba histolytica cysteine proteinase, putative 0.0058 0.0337 0.4443
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0042 0.0202 0.0229
Echinococcus granulosus dna polymerase eta 0.0022 0.0026 0.0022
Onchocerca volvulus 0.0042 0.0202 0.0461
Trypanosoma cruzi cysteine peptidase, putative 0.0221 0.1753 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0041 0.019 0.0448
Echinococcus granulosus GPCR family 2 0.0047 0.0245 0.0241
Brugia malayi Muscleblind-like protein 0.0305 0.2483 0.8214
Schistosoma mansoni ferritin 0.002 0.0004 0.0005
Mycobacterium tuberculosis Probable lipase LipE 0.0078 0.051 0.1218
Brugia malayi Cathepsin L-like precursor 0.0058 0.0337 0.1116
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0042 0.0202 0.0198
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0102 0.0336
Brugia malayi Cathepsin L-like precursor 0.0058 0.0337 0.1116
Mycobacterium ulcerans glutaminase 0.0291 0.2365 1
Mycobacterium tuberculosis Conserved protein 0.0078 0.051 0.1218
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0055 0.0311 0.1299
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0202 0.0229
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0042 0.0202 0.0667
Loa Loa (eye worm) hypothetical protein 0.0041 0.019 0.063
Echinococcus multilocularis geminin 0.103 0.8794 0.8794
Onchocerca volvulus 0.0042 0.0202 0.0461
Entamoeba histolytica cysteine protease, putative 0.003 0.0093 0.0955
Trypanosoma cruzi cysteine peptidase, putative 0.003 0.0093 0.053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0337 0.1411
Trichomonas vaginalis esterase, putative 0.0078 0.051 0.2142
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0245 0.0241
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0102 0.0336
Trypanosoma cruzi cysteine peptidase, putative 0.0221 0.1753 1
Brugia malayi hypothetical protein 0.0042 0.0202 0.0667
Onchocerca volvulus 0.0042 0.0202 0.0461
Schistosoma mansoni glutaminase 0.0291 0.2365 0.2689
Plasmodium vivax vivapain-2 0.0058 0.0337 0.6614
Treponema pallidum bacterioferrin (TpF1) 0.002 0.0004 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0042 0.0202 0.0198
Echinococcus granulosus Niemann Pick C1 protein 0.0147 0.111 0.1106
Onchocerca volvulus 0.0078 0.051 0.1878
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0042 0.0202 0.0198
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0026 0.0022
Loa Loa (eye worm) hypothetical protein 0.0305 0.2483 0.8214
Echinococcus granulosus somatostatin receptor 0.0042 0.0202 0.0198
Brugia malayi Papain family cysteine protease containing protein 0.0058 0.0337 0.1116
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Leishmania major cathepsin L-like protease 0.0221 0.1753 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0202 0.0198
Echinococcus granulosus hypothetical protein 0.0042 0.0202 0.0198
Brugia malayi hypothetical protein 0.0367 0.3022 1
Schistosoma mansoni histamine h1 receptor 0.0042 0.0202 0.0229
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0221 0.1753 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0042 0.0202 0.0229
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0245 0.0241
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0569 0.1361
Loa Loa (eye worm) hypothetical protein 0.015 0.1135 0.3754
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0337 0.1411
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0644 0.2131
Mycobacterium leprae conserved hypothetical protein 0.0078 0.051 0.7813
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0058 0.0337 0.0333
Schistosoma mansoni hypothetical protein 0.0042 0.0202 0.0229
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0221 0.1753 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0026 0.0149
Brugia malayi G-protein coupled receptor 0.0042 0.0202 0.0667
Schistosoma mansoni serine/threonine protein kinase 0.0367 0.3022 0.3437
Schistosoma mansoni eyes absent homolog 0.0089 0.0611 0.0695
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0102 0.0097
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0644 0.0732
Onchocerca volvulus Cathepsin L homolog 0.0058 0.0337 0.1084
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0102 0.0336
Onchocerca volvulus 0.0058 0.0337 0.1084
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.0723 0.2392
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0102 0.0116
Loa Loa (eye worm) hypothetical protein 0.0055 0.0311 0.1029
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0026 0.0053
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Entamoeba histolytica cysteine proteinase 1, putative 0.003 0.0093 0.0955
Schistosoma mansoni neuropeptide F-like receptor 0.0042 0.0202 0.0229
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.051 0.2142
Echinococcus multilocularis neuropeptide Y receptor 0.0042 0.0202 0.0198
Schistosoma mansoni coup transcription factor 0.0031 0.0102 0.0116
Entamoeba histolytica Flap nuclease, putative 0.003 0.0092 0.0948
Brugia malayi AKH receptor 0.0042 0.0202 0.0667
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.0651 0.1559
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0026 0.0149
Onchocerca volvulus 0.0035 0.0141 0.0182
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0199 0.0195
Loa Loa (eye worm) hypothetical protein 0.0031 0.0102 0.0336
Mycobacterium tuberculosis Probable hydrolase 0.0078 0.051 0.1218
Plasmodium vivax flap endonuclease 1, putative 0.003 0.0092 0.1813
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0337 0.1411
Echinococcus granulosus dna polymerase kappa 0.0022 0.0026 0.0022
Echinococcus granulosus neuropeptides capa receptor 0.0042 0.0202 0.0198
Leishmania major cathepsin L-like protease 0.0058 0.0337 0.1802
Onchocerca volvulus 0.0058 0.0337 0.1084
Echinococcus granulosus muscleblind protein 0.0305 0.2483 0.2479
Schistosoma mansoni apoferritin-2 0.002 0.0004 0.0005
Echinococcus granulosus expressed conserved protein 0.0096 0.0672 0.0668
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0644 0.2131
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0102 0.0097
Brugia malayi hypothetical protein 0.0042 0.0202 0.0667
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0202 0.0198
Echinococcus granulosus cathepsin l cysteine peptidase 0.0058 0.0337 0.0333
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0093 0.0376
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0102 0.0097
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Mycobacterium tuberculosis Probable reductase 0.0085 0.0569 0.1361
Trypanosoma cruzi cysteine peptidase, putative 0.0058 0.0337 0.1924
Loa Loa (eye worm) hypothetical protein 0.0041 0.019 0.063
Schistosoma mansoni cathepsin F (C01 family) 0.0039 0.0171 0.0194
Onchocerca volvulus 0.0171 0.1322 0.5613
Onchocerca volvulus 0.0042 0.0202 0.0461
Onchocerca volvulus 0.0039 0.0171 0.0318
Echinococcus granulosus sex peptide receptor 0.0042 0.0202 0.0198
Brugia malayi Dopamine receptor protein 1 0.0042 0.0202 0.0667
Brugia malayi beta-lactamase family protein 0.0078 0.051 0.1687
Schistosoma mansoni amine GPCR 0.0042 0.0202 0.0229
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.003 0.0092 0.0527
Brugia malayi Cathepsin L-like precursor 0.0058 0.0337 0.1116
Loa Loa (eye worm) glutaminase 0.0291 0.2365 0.7826
Brugia malayi G-protein coupled receptor 0.0042 0.0202 0.0667
Mycobacterium ulcerans acyl-CoA synthetase 0.0055 0.0311 0.1299
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0141 0.0137
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0471 0.0536
Echinococcus multilocularis dna polymerase eta 0.0022 0.0026 0.0022
Loa Loa (eye worm) pigment dispersing factor receptor c 0.015 0.1135 0.3754
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0098 0.1925
Echinococcus granulosus neuropeptides capa receptor 0.0042 0.0202 0.0198
Plasmodium vivax SET domain protein, putative 0.0035 0.0141 0.2768
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0337 0.1411
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0102 0.0336
Echinococcus granulosus neuropeptide receptor A26 0.0042 0.0202 0.0198
Loa Loa (eye worm) hypothetical protein 0.0078 0.051 0.1687
Onchocerca volvulus 0.0078 0.051 0.1878
Entamoeba histolytica hypothetical protein 0.0042 0.0199 0.247
Loa Loa (eye worm) hypothetical protein 0.0044 0.0217 0.0717
Brugia malayi Calcitonin receptor-like protein seb-1 0.015 0.1135 0.3754
Plasmodium falciparum acyl-CoA synthetase 0.0041 0.019 0.3996
Schistosoma mansoni survival motor neuron protein 0.0055 0.0313 0.0356
Brugia malayi hypothetical protein 0.0042 0.0202 0.0667
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Schistosoma mansoni hypothetical protein 0.0042 0.0202 0.0229
Brugia malayi hypothetical protein 0.0042 0.0202 0.0667
Brugia malayi Serine/threonine-protein kinase SULU 0.0367 0.3022 1
Leishmania major trypanothione reductase 0.0037 0.0156 0.0753
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0042 0.0202 0.0229
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0042 0.0202 0.0198
Entamoeba histolytica cysteine protease, putative 0.003 0.0093 0.0955
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0337 0.1411
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0042 0.0202 0.0229
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0042 0.0202 0.0667
Loa Loa (eye worm) hypothetical protein 0.0171 0.1322 0.4373
Entamoeba histolytica cysteine protease, putative 0.003 0.0093 0.0955
Brugia malayi Cathepsin L-like precursor 0.0039 0.0171 0.0565
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.0202 0.0198
Schistosoma mansoni myosin xvIII 0.0042 0.0202 0.0229
Echinococcus multilocularis Niemann Pick C1 protein 0.0103 0.0726 0.0723
Entamoeba histolytica cysteine protease, putative 0.003 0.0093 0.0955
Leishmania major cathepsin L-like protease 0.0221 0.1753 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.051 0.058
Echinococcus multilocularis serotonin receptor 0.0042 0.0202 0.0198
Echinococcus multilocularis cysteine protease 0.0058 0.0337 0.0333
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Brugia malayi hypothetical protein 0.0042 0.0202 0.0667
Brugia malayi ORL1-like opioid receptor 0.0042 0.0202 0.0667
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0058 0.0337 0.1411
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Schistosoma mansoni cathepsin F (C01 family) 0.0058 0.0337 0.0383
Echinococcus granulosus survival motor neuron protein 1 0.027 0.2185 0.2182
Schistosoma mansoni biogenic amine (5HT) receptor 0.0042 0.0202 0.0229
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0055 0.0311 0.474
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0102 0.0336
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0042 0.0202 0.0667
Leishmania major 4-coumarate:coa ligase-like protein 0.0055 0.0311 0.165
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0644 0.064
Loa Loa (eye worm) hypothetical protein 0.0078 0.051 0.1687
Brugia malayi AMP-binding enzyme family protein 0.0055 0.0311 0.1029
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0042 0.0202 0.0198
Echinococcus multilocularis neuropeptide Y receptor 0.0042 0.0202 0.0198
Echinococcus multilocularis cathepsin L cysteine protease 0.0058 0.0337 0.0333
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0026 0.0086
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0171 0.0401
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.051 0.2909
Onchocerca volvulus Neuropeptide F receptor homolog 0.0042 0.0202 0.0461
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0199 0.0195
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0093 0.0955
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.0651 1
Schistosoma mansoni hypothetical protein 0.0047 0.0245 0.0279
Leishmania major cathepsin L-like protease 0.0058 0.0337 0.1802
Trichomonas vaginalis flap endonuclease-1, putative 0.003 0.0092 0.0374
Entamoeba histolytica cysteine protease, putative 0.003 0.0093 0.0955
Trypanosoma cruzi major cysteine proteinase, putative 0.0173 0.1342 0.7656
Brugia malayi glutathione reductase 0.0037 0.0156 0.0516
Echinococcus granulosus serotonin receptor 0.0042 0.0202 0.0198
Trypanosoma cruzi cysteine peptidase, putative 0.0221 0.1753 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0569 0.1361
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.003 0.0093 0.0106
Echinococcus multilocularis cathepsin L cysteine protease 0.0058 0.0337 0.0333
Schistosoma mansoni biogenic amine receptor 0.0042 0.0202 0.0229
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0202 0.0229
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0337 0.1411
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0471 0.2577
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0141 0.0137
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0042 0.0202 0.0198
Brugia malayi hypothetical protein 0.0042 0.0202 0.0667
Schistosoma mansoni opsin-like receptor 0.0042 0.0202 0.0229
Schistosoma mansoni cellular tumor antigen P53 0.0171 0.1322 0.1503
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0644 0.064
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Onchocerca volvulus 0.0042 0.0202 0.0461
Onchocerca volvulus 0.0058 0.0337 0.1084
Loa Loa (eye worm) cysteine protease 0.0058 0.0337 0.1116
Loa Loa (eye worm) hypothetical protein 0.0031 0.0102 0.0336
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0042 0.0202 0.0229
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.0651 0.1559
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.016 0.0156
Trypanosoma brucei trypanothione reductase 0.0037 0.0156 0.0753
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0644 0.064
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0102 0.0097
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0102 0.0097
Echinococcus granulosus g protein coupled receptor 0.0042 0.0202 0.0198
Echinococcus granulosus 7tm_1 domain containing protein 0.0042 0.0202 0.0198
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0042 0.0202 0.0198
Brugia malayi Cathepsin L-like precursor 0.0039 0.0171 0.0565
Schistosoma mansoni patched 1 0.0044 0.0217 0.0246
Mycobacterium tuberculosis Probable esterase LipL 0.0078 0.051 0.1218
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0093 0.0376
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.051 0.2142
Entamoeba histolytica cysteine proteinase, putative 0.0058 0.0337 0.4443
Schistosoma mansoni ferritin light chain 0.002 0.0004 0.0005
Schistosoma mansoni amine GPCR 0.0042 0.0202 0.0229
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Echinococcus multilocularis protein patched 0.0044 0.0217 0.0213
Loa Loa (eye worm) hypothetical protein 0.0047 0.0245 0.0811
Onchocerca volvulus 0.0078 0.051 0.1878
Brugia malayi AMP-binding enzyme family protein 0.0055 0.0311 0.1029
Loa Loa (eye worm) hypothetical protein 0.0089 0.0611 0.2023
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0367 0.3022 0.3019
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0202 0.0198
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.051 0.058
Loa Loa (eye worm) hypothetical protein 0.0039 0.0171 0.0565
Loa Loa (eye worm) hypothetical protein 0.0031 0.0102 0.0336
Plasmodium vivax vivapain-1 0.003 0.0093 0.1823
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0221 0.1753 1
Trichomonas vaginalis glutaminase, putative 0.0291 0.2365 1
Onchocerca volvulus 0.0042 0.0202 0.0461
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Onchocerca volvulus 0.0058 0.0337 0.1084
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0098 0.0418
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Echinococcus granulosus neuropeptide Y receptor 0.0042 0.0202 0.0198
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0042 0.0202 0.0198
Echinococcus granulosus beta LACTamase domain containing family member 0.0078 0.051 0.0506
Echinococcus multilocularis dro:myosuppressin receptor 0.0042 0.0202 0.0198
Echinococcus multilocularis G protein coupled receptor 139 0.0042 0.0202 0.0198
Echinococcus granulosus cathepsin l1 0.0039 0.0171 0.0167
Echinococcus multilocularis fmrfamide receptor 0.0042 0.0202 0.0198
Brugia malayi neuropeptide F receptor 0.0042 0.0202 0.0667
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Brugia malayi Niemann-Pick C1 protein precursor 0.0103 0.0726 0.2404
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0171 0.0401
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0102 0.0116
Onchocerca volvulus 0.0042 0.0202 0.0461
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0471 0.1978
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0337 0.1411
Brugia malayi larval opioid receptor 0.0042 0.0202 0.0667
Entamoeba histolytica cysteine protease, putative 0.0058 0.0337 0.4443
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0337 0.1411
Echinococcus granulosus alpha 1A adrenergic receptor 0.0042 0.0202 0.0198
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Schistosoma mansoni opsin-like receptor 0.0042 0.0202 0.0229
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.003 0.0093 0.0106
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0245 0.0811
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0058 0.0337 0.1116
Schistosoma mansoni amine GPCR 0.0042 0.0202 0.0229
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0042 0.0202 0.0229
Entamoeba histolytica cysteine protease, putative 0.003 0.0093 0.0955
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0042 0.0202 0.0461
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0202 0.0229
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0098 0.056
Brugia malayi beta-lactamase family protein 0.0078 0.051 0.1687
Brugia malayi Papain family cysteine protease containing protein 0.003 0.0093 0.0308
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0042 0.0202 0.0229
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0058 0.0337 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0078 0.051 0.1218
Brugia malayi hypothetical protein 0.003 0.0098 0.0325
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0102 0.0097
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0078 0.051 0.1687
Entamoeba histolytica cysteine protease, putative 0.003 0.0093 0.0955
Loa Loa (eye worm) hypothetical protein 0.0041 0.019 0.063
Entamoeba histolytica hypothetical protein 0.0042 0.0199 0.247
Echinococcus multilocularis G-protein coupled receptor, putative 0.0042 0.0202 0.0198
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0221 0.1753 1
Brugia malayi steroid hormone receptor 0.0031 0.0102 0.0336
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0245 0.0241
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0026 0.0086
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0311 0.0739
Schistosoma mansoni neuropeptide receptor 0.0042 0.0202 0.0229
Echinococcus granulosus flap endonuclease 1 0.003 0.0092 0.0088
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0055 0.0311 0.1299
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0102 0.0116
Onchocerca volvulus 0.0042 0.0202 0.0461
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0245 0.0811
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0102 0.0116
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0098 0.056
Schistosoma mansoni ferritin 0.002 0.0004 0.0005
Onchocerca volvulus Cathepsin F homolog 0.0058 0.0337 0.1084
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Brugia malayi hypothetical protein 0.0042 0.0202 0.0667
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0202 0.0198
Entamoeba histolytica acyl-CoA synthetase, putative 0.0055 0.0311 0.4068
Brugia malayi Thioredoxin reductase 0.0037 0.0156 0.0516
Echinococcus granulosus allatostatin A receptor 0.0042 0.0202 0.0198
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0042 0.0202 0.0198
Echinococcus granulosus 7TM GPCR rhodopsin 0.0042 0.0202 0.0198
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0221 0.1753 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0102 0.0097
Echinococcus granulosus cysteine protease 0.003 0.0093 0.0089
Trypanosoma cruzi cysteine proteinase, putative 0.003 0.0093 0.053
Brugia malayi neuropeptide F receptor 0.0042 0.0202 0.0667
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0202 0.0229
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0141 0.0161
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0102 0.0336
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0471 0.1125
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0202 0.0229
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0041 0.019 0.0788
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0102 0.0336
Brugia malayi Pre-SET motif family protein 0.0035 0.0141 0.0467
Echinococcus granulosus g protein coupled receptor 0.0042 0.0202 0.0198
Echinococcus multilocularis muscleblind protein 0.0305 0.2483 0.2479
Onchocerca volvulus 0.0042 0.0202 0.0461
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0337 0.1411
Toxoplasma gondii thioredoxin reductase 0.0037 0.0156 0.1523
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.0202 0.0198
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0102 0.0336
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.016 0.0156
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0337 0.1411
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0337 0.1411
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0171 0.0401
Echinococcus multilocularis protein dispatched 1 0.005 0.0271 0.0267
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0026 0.0022
Entamoeba histolytica hypothetical protein 0.0042 0.0199 0.247
Schistosoma mansoni neuropeptide receptor 0.0042 0.0202 0.0229
Echinococcus granulosus biogenic amine 5HT receptor 0.0042 0.0202 0.0198
Loa Loa (eye worm) hypothetical protein 0.003 0.0098 0.0325
Entamoeba histolytica cysteine protease, putative 0.003 0.0093 0.0955
Loa Loa (eye worm) hypothetical protein 0.0055 0.0311 0.1029
Loa Loa (eye worm) hypothetical protein 0.0058 0.0337 0.1116
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0098 0.0234
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.003 0.0093 0.053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0102 0.0336
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0202 0.0198
Brugia malayi hypothetical protein 0.0042 0.0199 0.0659
Plasmodium vivax glutathione reductase, putative 0.0037 0.0156 0.306
Onchocerca volvulus 0.0042 0.0202 0.0461
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0042 0.0202 0.0198
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0039 0.0171 0.0705
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0102 0.0097
Schistosoma mansoni neuropeptide f receptor 76f 0.0042 0.0202 0.0229
Schistosoma mansoni hypothetical protein 0.0042 0.0199 0.0226
Mycobacterium ulcerans hypothetical protein 0.0055 0.0311 0.1299
Brugia malayi cathepsin L-like precursor 0.0039 0.0171 0.0565
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Brugia malayi hypothetical protein 0.002 0.0004 0.0014
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.0202 0.0198
Brugia malayi Cathepsin L-like cysteine proteinase 0.0039 0.0171 0.0565
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0217 0.0213
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0039 0.0171 0.0401
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0202 0.0198
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0042 0.0202 0.0229
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0026 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0102 0.0336
Loa Loa (eye worm) neuropeptide F receptor 0.0042 0.0202 0.0667
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0569 0.1361
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0041 0.019 0.5
Onchocerca volvulus 0.0042 0.0202 0.0461
Brugia malayi Tachykinin-like peptides receptor 99D 0.0042 0.0202 0.0667
Schistosoma mansoni neuropeptide F-like receptor 0.0042 0.0202 0.0229
Schistosoma mansoni hypothetical protein 0.0042 0.0203 0.0231
Schistosoma mansoni hypothetical protein 0.0042 0.0202 0.0229
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0026 0.0093
Loa Loa (eye worm) TYRA-2 protein 0.0042 0.0202 0.0667
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0221 0.1753 1
Brugia malayi RE15519p 0.0042 0.0202 0.0667
Schistosoma mansoni alpha-1 adrenergic receptor 0.0042 0.0202 0.0229
Echinococcus granulosus dro:myosuppressin receptor 0.0042 0.0202 0.0198
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.0202 0.0198
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0569 0.1361
Schistosoma mansoni hypothetical protein 0.0047 0.0245 0.0279
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0026 0.0149
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0042 0.0202 0.0229
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0026 0.0093
Loa Loa (eye worm) ctsf protein 0.0058 0.0337 0.1116
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0471 0.0467
Brugia malayi nuclear receptor NHR-88 0.0031 0.0102 0.0336
Mycobacterium tuberculosis Conserved protein 0.0078 0.051 0.1218
Loa Loa (eye worm) hypothetical protein 0.0031 0.0102 0.0336
Mycobacterium ulcerans esterase/lipase LipP 0.0078 0.051 0.2142
Entamoeba histolytica cysteine protease, putative 0.003 0.0093 0.0955
Schistosoma mansoni biogenic amine (5HT) receptor 0.0042 0.0202 0.0229
Schistosoma mansoni amine GPCR 0.0042 0.0202 0.0229
Brugia malayi putative neuropeptide receptor NPR1 0.0042 0.0202 0.0667
Echinococcus multilocularis neuropeptide receptor A26 0.0042 0.0202 0.0198
Plasmodium falciparum glutathione reductase 0.0037 0.0156 0.2597
Entamoeba histolytica cysteine protease, putative 0.003 0.0093 0.0955
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0156 0.089
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0337 0.1411
Echinococcus multilocularis fmrfamide receptor 0.0042 0.0202 0.0198
Schistosoma mansoni DNA polymerase eta 0.0022 0.0026 0.003
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0102 0.0116
Schistosoma mansoni ferritin 0.002 0.0004 0.0005
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0042 0.0202 0.0198
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0102 0.0336
Brugia malayi G protein-coupled receptor 0.0042 0.0202 0.0667
Loa Loa (eye worm) beta-lactamase 0.0078 0.051 0.1687
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0217 0.0717
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0337 0.1411
Onchocerca volvulus 0.0058 0.0337 0.1084
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0102 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0102 0.0336
Brugia malayi sulfakinin receptor protein 0.0042 0.0202 0.0667
Schistosoma mansoni hypothetical protein 0.103 0.8794 1
Brugia malayi GnHR receptor homolog 0.0042 0.0202 0.0667
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0026 0.0149
Brugia malayi Serotonin receptor 0.0042 0.0202 0.0667
Plasmodium vivax unspecified product 0.003 0.0093 0.1823
Loa Loa (eye worm) melatonin receptor type 1A 0.0042 0.0202 0.0667
Loa Loa (eye worm) hypothetical protein 0.0039 0.0171 0.0565
Onchocerca volvulus 0.0281 0.2275 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0569 0.1361
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0221 0.1753 1
Brugia malayi nuclear hormone receptor 0.0031 0.0102 0.0336
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Mycobacterium ulcerans hypothetical protein 0.0078 0.051 0.2142
Loa Loa (eye worm) hypothetical protein 0.0078 0.051 0.1687
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0202 0.0229
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0102 0.0116
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0093 0.0955
Mycobacterium ulcerans acyl-CoA synthetase 0.0055 0.0311 0.1299
Onchocerca volvulus 0.0042 0.0202 0.0461
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0471 0.9072
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0042 0.0202 0.0667
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0202 0.0229
Leishmania major cathepsin L-like protease 0.0221 0.1753 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.003 0.0093 0.0106
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0245 0.0241
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0042 0.0202 0.0667
Loa Loa (eye worm) hypothetical protein 0.0041 0.019 0.063
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Leishmania major 4-coumarate:coa ligase-like protein 0.0055 0.0311 0.165
Schistosoma mansoni biogenic amine receptor 0.0042 0.0202 0.0229
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0026 0.0086
Mycobacterium ulcerans acyl-CoA synthetase 0.0055 0.0311 0.1299
Schistosoma mansoni cathepsin F (C01 family) 0.0058 0.0337 0.0383
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0026 0.0093
Plasmodium vivax vivapain-2 0.0058 0.0337 0.6614
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0217 0.0213
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0199 0.0226
Echinococcus granulosus tachykinin peptides receptor 99D 0.0042 0.0202 0.0198
Brugia malayi glutaminase DH11.1 0.0291 0.2365 0.7826
Toxoplasma gondii ABC1 family protein 0.0078 0.051 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0337 0.1411
Onchocerca volvulus 0.0055 0.0311 0.0963
Brugia malayi CHE-14 protein 0.0044 0.0217 0.0717
Mycobacterium ulcerans lipase LipD 0.0078 0.051 0.2142
Echinococcus multilocularis neuropeptide FF receptor 2 0.0042 0.0202 0.0198
Echinococcus granulosus neuropeptide Y receptor 0.0042 0.0202 0.0198
Onchocerca volvulus 0.0058 0.0337 0.1084
Echinococcus granulosus g-protein coupled receptor 0.0042 0.0202 0.0198
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.0202 0.0198
Echinococcus granulosus Niemann Pick C1 protein 0.0103 0.0726 0.0723
Echinococcus granulosus neuropeptide receptor 0.0042 0.0202 0.0198
Echinococcus multilocularis neuropeptide receptor 0.0042 0.0202 0.0198
Leishmania major 4-coumarate:coa ligase-like protein 0.0055 0.0311 0.165
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0055 0.0311 0.0739
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.013 0.0126
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0313 0.1036
Leishmania major hypothetical protein, conserved 0.003 0.0098 0.0418
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0221 0.1753 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Echinococcus granulosus g protein coupled receptor 0.0042 0.0202 0.0198
Trypanosoma cruzi cysteine protease, putative 0.003 0.0093 0.053
Brugia malayi Papain family cysteine protease containing protein 0.003 0.0093 0.0308
Loa Loa (eye worm) neuropeptide F receptor 0.0042 0.0202 0.0667
Brugia malayi Dopamine receptor protein 2 0.0042 0.0202 0.0667
Echinococcus granulosus cathepsin L 0.003 0.0093 0.0089
Loa Loa (eye worm) hypothetical protein 0.027 0.2185 0.7231
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0102 0.0097
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0471 0.1978
Echinococcus granulosus neuropeptide s receptor 0.0042 0.0202 0.0198
Onchocerca volvulus 0.0042 0.0202 0.0461
Loa Loa (eye worm) hypothetical protein 0.0041 0.019 0.063
Loa Loa (eye worm) hypothetical protein 0.0031 0.0102 0.0336
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0141 0.1167
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0042 0.0202 0.0667
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0141 0.0161
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0102 0.0336
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.0651 0.1559
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0202 0.0198
Echinococcus multilocularis serotonin receptor 0.0042 0.0202 0.0198
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0865 0.7356 0.7355
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0042 0.0202 0.0667
Echinococcus multilocularis neuropeptide s receptor 0.0042 0.0202 0.0198
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0102 0.0336
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Plasmodium vivax hypothetical protein, conserved 0.0078 0.051 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0141 0.0137
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0102 0.0097
Echinococcus multilocularis sex peptide receptor 0.0042 0.0202 0.0198
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0104 0.074 0.0842
Mycobacterium tuberculosis Probable lipase LipD 0.0078 0.051 0.1218
Mycobacterium tuberculosis Conserved protein 0.0078 0.051 0.1218
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0497 0.4155 1
Echinococcus multilocularis cysteine protease 0.0058 0.0337 0.0333
Loa Loa (eye worm) hypothetical protein 0.0022 0.0026 0.0086
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Echinococcus granulosus peptide allatostatin:somatostatin 0.0042 0.0202 0.0198
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0367 0.3022 1
Plasmodium falciparum thioredoxin reductase 0.0037 0.0156 0.2597
Plasmodium vivax vivapain-3 0.003 0.0093 0.1823
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0102 0.0097
Onchocerca volvulus 0.0042 0.0202 0.0461
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0337 0.1411
Loa Loa (eye worm) hypothetical protein 0.0035 0.0141 0.0467
Entamoeba histolytica acyl-CoA synthetase, putative 0.0055 0.0311 0.4068
Loa Loa (eye worm) G-protein coupled receptor 0.0042 0.0202 0.0667
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0102 0.0336
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0337 0.1411
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0058 0.0337 0.1411
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0058 0.0337 0.0333
Entamoeba histolytica cysteine protease, putative 0.003 0.0093 0.0955
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0058 0.0337 0.1116
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0058 0.0337 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0102 0.0336
Plasmodium falciparum cysteine proteinase falcipain 3 0.0058 0.0337 1
Entamoeba histolytica cysteine proteinase, putative 0.0039 0.0171 0.2065
Schistosoma mansoni hypothetical protein 0.0047 0.0245 0.0279
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0337 0.1411
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0569 0.8731
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0247 0.1979 0.6547
Loa Loa (eye worm) hypothetical protein 0.0305 0.2483 0.8214
Schistosoma mansoni biogenic amine receptor 0.0042 0.0202 0.0229
Loa Loa (eye worm) glutathione reductase 0.0037 0.0156 0.0516
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0202 0.0198
Echinococcus granulosus neuropeptide receptor 0.0042 0.0202 0.0198
Mycobacterium ulcerans beta-lactamase 0.0078 0.051 0.2142
Echinococcus granulosus cathepsin L cysteine protease 0.003 0.0093 0.0089
Echinococcus multilocularis neuropeptides capa receptor 0.0042 0.0202 0.0198
Schistosoma mansoni hypothetical protein 0.0047 0.0245 0.0279
Leishmania major hypothetical protein, conserved 0.0078 0.051 0.2802
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0098 0.0234
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0078 0.051 0.1218
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0102 0.0116
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0202 0.0198
Leishmania major cathepsin L-like protease 0.0058 0.0337 0.1802
Echinococcus multilocularis GPCR, family 2 0.0047 0.0245 0.0241
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0245 0.0811
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.0202 0.0198
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0202 0.0198
Brugia malayi Cathepsin L-like precursor 0.0058 0.0337 0.1116
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0026 0.0022
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0042 0.0202 0.0198
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0103 0.0726 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0042 0.0202 0.0198
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0042 0.0202 0.0229
Plasmodium vivax acyl-CoA synthetase, putative 0.0041 0.019 0.3732
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0202 0.0198
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.051 0.2909
Mycobacterium leprae Probable lipase LipE 0.0078 0.051 0.7813
Loa Loa (eye worm) hypothetical protein 0.0103 0.0726 0.2404
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0078 0.051 0.1687
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0102 0.0116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0221 0.1753 1
Echinococcus multilocularis expressed conserved protein 0.0096 0.0672 0.0668
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0102 0.0097
Echinococcus multilocularis cathepsin L 0.003 0.0093 0.0089
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0337 0.1411
Trypanosoma cruzi cruzipain precursor, putative 0.0221 0.1753 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0303 0.1002
Trypanosoma cruzi cysteine proteinase, putative 0.003 0.0093 0.053
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0093 0.0955
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0156 0.0516
Brugia malayi hypothetical protein 0.0042 0.0202 0.0667
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0078 0.051 0.1218
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0102 0.0116
Loa Loa (eye worm) hypothetical protein 0.0039 0.0171 0.0565
Loa Loa (eye worm) hypothetical protein 0.0078 0.051 0.1687
Brugia malayi ecdysteroid receptor 0.0031 0.0102 0.0336
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0102 0.0336
Echinococcus multilocularis muscleblind protein 1 0.0305 0.2483 0.2479
Onchocerca volvulus Cathepsin L homolog 0.0058 0.0337 0.1084
Echinococcus multilocularis survival motor neuron protein 1 0.027 0.2185 0.2182
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0042 0.0202 0.0667
Schistosoma mansoni adenoreceptor 0.0042 0.0202 0.0229
Brugia malayi G protein-coupled receptor F59B2.13 0.0042 0.0202 0.0667
Onchocerca volvulus 0.0055 0.0313 0.0973
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0102 0.0336
Giardia lamblia Flap structure-specific endonuclease 0.003 0.0092 1
Schistosoma mansoni opsin-like receptor 0.0042 0.0202 0.0229
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0102 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.0337 0.1411
Echinococcus multilocularis tumor protein p63 0.1169 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0141 0.0161
Toxoplasma gondii cathepsin CPL 0.0058 0.0337 0.5864
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0156 0.306
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0202 0.0198
Schistosoma mansoni hypothetical protein 0.103 0.8794 1
Brugia malayi follicle stimulating hormone receptor 0.0042 0.0202 0.0667
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Loa Loa (eye worm) hypothetical protein 0.0055 0.0311 0.1029
Brugia malayi Flap endonuclease-1 0.003 0.0092 0.0306
Echinococcus multilocularis beta LACTamase domain containing family member 0.0078 0.051 0.0506
Schistosoma mansoni amine GPCR 0.0042 0.0202 0.0229
Loa Loa (eye worm) hypothetical protein 0.0042 0.0202 0.0667
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0102 0.0336
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0471 0.0536
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0055 0.0311 0.1299

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1476 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent))] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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