Detailed information for compound 1308292

Basic information

Technical information
  • TDR Targets ID: 1308292
  • Name: (3R,3aS,7R,7aS)-7-methyl-2-(phenylmethyl)-3-[ 4-(trifluoromethyl)phenyl]-3a,6,7,7a-tetrahyd ro-3H-isoindol-1-one
  • MW: 385.422 | Formula: C23H22F3NO
  • H donors: 0 H acceptors: 1 LogP: 5.11 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@@H]1CC=C[C@H]2[C@H]1C(=O)N([C@H]2c1ccc(cc1)C(F)(F)F)Cc1ccccc1
  • InChi: 1S/C23H22F3NO/c1-15-6-5-9-19-20(15)22(28)27(14-16-7-3-2-4-8-16)21(19)17-10-12-18(13-11-17)23(24,25)26/h2-5,7-13,15,19-21H,6,14H2,1H3/t15-,19+,20+,21+/m1/s1
  • InChiKey: VPBDWNHJPXRKRA-DVMWJLJYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (3R,3aS,7R,7aS)-2-(benzyl)-7-methyl-3-[4-(trifluoromethyl)phenyl]-3a,6,7,7a-tetrahydro-3H-isoindol-1-one
  • MLS000882819
  • SMR000465386

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) phosphatidylinositol 3 0.0155 0.0634 0.0928
Schistosoma mansoni ap endonuclease 0.0023 0.0025 0.0017
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0256 0.1101 0.1094
Loa Loa (eye worm) hypothetical protein 0.0038 0.0097 0.0132
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0273 0.0265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0762 0.343 0.7313
Loa Loa (eye worm) hypothetical protein 0.0155 0.0634 0.0928
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0256 0.1101 0.2312
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0256 0.1101 0.1621
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0155 0.0634 0.1308
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.012 0.0113
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0893 0.4033 0.8894
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1649 0.752 0.7518
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0273 0.0393
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0155 0.0634 0.1716
Loa Loa (eye worm) hypothetical protein 0.0322 0.1403 0.2068
Trichomonas vaginalis PIKK family atypical protein kinase 0.081 0.3655 0.7796
Brugia malayi Cytochrome P450 family protein 0.0028 0.0051 0.0051
Schistosoma mansoni hypothetical protein 0.0019 0.0008 0.0000061935
Entamoeba histolytica hypothetical protein 0.0155 0.0634 0.1308
Echinococcus multilocularis GPCR, family 2 0.0019 0.0008 0.0000061935
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0008 0.0000061935
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2188 1 1
Onchocerca volvulus 0.0038 0.0097 0.0092
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0273 0.0265
Plasmodium vivax SET domain protein, putative 0.0036 0.0086 0.0571
Loa Loa (eye worm) hypothetical protein 0.0148 0.0602 0.0881
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0396 0.1746 0.174
Leishmania major phosphatidylinositol kinase, putative 0.0155 0.0634 0.1383
Trichomonas vaginalis PIKK family atypical protein kinase 0.0893 0.4033 0.8608
Schistosoma mansoni hypothetical protein 0.0019 0.0008 0.0000061935
Schistosoma mansoni hypothetical protein 0.0283 0.1225 0.1219
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0827 0.3732 0.8229
Trichomonas vaginalis conserved hypothetical protein 0.0283 0.1225 0.2579
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1357 0.2861
Echinococcus multilocularis Zinc finger, PHD finger 0.0256 0.1101 0.1094
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2188 1 1
Brugia malayi beta-lactamase 0.0038 0.0097 0.0097
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0256 0.1101 0.2312
Trichomonas vaginalis PIKK family atypical protein kinase 0.068 0.3051 0.65
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0241 0.1033 0.1026
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.1357 0.1357
Trichomonas vaginalis PIKK family atypical protein kinase 0.0827 0.3731 0.7959
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0616 0.2759 0.2759
Loa Loa (eye worm) acetyltransferase 0.0175 0.0727 0.1066
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0157 0.041
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0273 0.0265
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0778 0.3505 0.7474
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0893 0.4033 0.4028
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0914 0.1909
Echinococcus granulosus neuropeptide receptor A26 0.0568 0.2536 0.253
Loa Loa (eye worm) hypothetical protein 0.0218 0.0925 0.1359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0609 0.2728 0.5805
Echinococcus multilocularis serine protein kinase ATM 0.0396 0.1746 0.174
Plasmodium vivax hypothetical protein 0.0155 0.0634 0.5656
Brugia malayi FAT domain containing protein 0.0283 0.1225 0.1225
Giardia lamblia Phosphatidylinositol 4-kinase 0.0155 0.0634 0.1519
Brugia malayi TAR-binding protein 0.0076 0.0273 0.0273
Loa Loa (eye worm) hypothetical protein 0.0041 0.011 0.0151
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0155 0.0634 0.1308
Echinococcus multilocularis geminin 0.0175 0.0728 0.0721
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0273 0.0265
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0097 0.0097
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1001 0.4534 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0097 0.0089
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0584 0.0855
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0268 0.1155 0.1148
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0155 0.0634 0.0626
Loa Loa (eye worm) phosphatidylinositol 3 0.0155 0.0634 0.0928
Entamoeba histolytica hypothetical protein 0.0043 0.012 0.0205
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2188 1 1
Echinococcus granulosus tar DNA binding protein 0.0076 0.0273 0.0265
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0000091757
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0051 0.0064
Schistosoma mansoni hypothetical protein 0.0043 0.012 0.0113
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0396 0.1746 0.1746
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0025 0.0037
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0086 0.0078
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1033 0.4681 0.4681
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1357 0.2861
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0321 0.1401 0.3433
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0893 0.4033 0.8608
Trichomonas vaginalis PIKK family atypical protein kinase 0.081 0.3655 0.7796
Brugia malayi beta-lactamase family protein 0.0038 0.0097 0.0097
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0155 0.0634 0.0626
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0256 0.1101 0.2998
Trichomonas vaginalis PIKK family atypical protein kinase 0.0893 0.4033 0.8608
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.3354 0.7149
Brugia malayi RNA binding protein 0.0076 0.0273 0.0273
Trichomonas vaginalis PIKK family atypical protein kinase 0.081 0.3655 0.7796
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0008 0.0000091757
Onchocerca volvulus Huntingtin homolog 0.0148 0.0602 0.4476
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0283 0.1225 0.1219
Trichomonas vaginalis PIKK family atypical protein kinase 0.081 0.3655 0.7796
Entamoeba histolytica protein kinase rad3, putative 0.0396 0.1746 0.3697
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0155 0.0634 0.5656
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0893 0.4033 0.8894
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0863 0.18
Loa Loa (eye worm) phosphatidylinositol 3 0.0155 0.0634 0.0928
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0273 0.0265
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0893 0.4033 0.8894
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0893 0.4033 0.4033
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0256 0.1101 0.2312
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0044 0.008
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0256 0.1101 0.2312
Brugia malayi beta-lactamase family protein 0.0038 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0283 0.1225 0.1805
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.0727 0.0719
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.012 0.0113
Loa Loa (eye worm) phosphatidylinositol 3 0.0155 0.0634 0.0928
Leishmania major hypothetical protein, unknown function 0.0155 0.0634 0.1383
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0396 0.1746 0.1746
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0155 0.0634 0.1383
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0097 0.0855
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0704 0.0697
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0396 0.1746 0.174
Onchocerca volvulus Huntingtin homolog 0.0148 0.0602 0.4476
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.3352 0.7146
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1033 0.4681 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.0051 0.4881
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0025 0.0037
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0155 0.0634 0.0626
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0025 0.5
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.068 0.3051 0.6725
Schistosoma mansoni fkbp-rapamycin associated protein 0.0396 0.1746 0.174
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0245 0.1049 1
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0863 0.18
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.0727 0.0719
Trichomonas vaginalis PIKK family atypical protein kinase 0.0527 0.2349 0.4992
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0198 0.0198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.3354 0.7149
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0097 0.0197
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0086 0.0078
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.1033 0.4681 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0155 0.0634 0.0626
Loa Loa (eye worm) hypothetical protein 0.0036 0.0086 0.0116
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0097 0.1422
Echinococcus granulosus geminin 0.0175 0.0728 0.0721
Loa Loa (eye worm) hypothetical protein 0.0027 0.0044 0.0053
Brugia malayi Pre-SET motif family protein 0.0036 0.0086 0.0086
Giardia lamblia Hypothetical protein 0.0155 0.0634 0.1519
Giardia lamblia GTOR 0.0893 0.4033 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0893 0.4033 0.8608
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0155 0.0634 0.1308
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0044 0.0177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0527 0.2349 0.4992
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0396 0.1746 0.3841
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0044 0.0099
Entamoeba histolytica hypothetical protein 0.0155 0.0634 0.1308
Loa Loa (eye worm) hypothetical protein 0.0396 0.1746 0.2577
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0155 0.0634 0.0634
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0678 0.3045 0.3039
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0283 0.1225 0.1219
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0423 0.1868 0.3959
Onchocerca volvulus 0.0038 0.0097 0.0092
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0097 0.0155
Echinococcus multilocularis neuropeptide s receptor 0.0568 0.2536 0.253
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0893 0.4033 0.4028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0586 0.2618 0.557
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0097 0.0089
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0778 0.3505 0.7474
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0097 0.0089
Mycobacterium leprae conserved hypothetical protein 0.0155 0.0634 1
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0863 0.18
Schistosoma mansoni hypothetical protein 0.0041 0.011 0.0102
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0893 0.4033 0.4028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0827 0.3731 0.7959
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0863 0.18
Loa Loa (eye worm) hypothetical protein 0.0038 0.0097 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0827 0.3731 0.7959
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.0925 0.7278
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0097 0.0855
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0025 0.1904
Trichomonas vaginalis PIKK family atypical protein kinase 0.068 0.3051 0.65
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0504 0.2241 0.4934
Leishmania major cytochrome p450-like protein 0.0028 0.0051 0.0096
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0008 0.0000061935
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0396 0.1746 0.174
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0025 0.0163
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.008 0.0072
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0155 0.0634 0.0626
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0155 0.0634 0.0626
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0097 0.0132
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0256 0.1101 0.2312
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0256 0.1101 0.1094
Plasmodium vivax hypothetical protein, conserved 0.0155 0.0634 0.5656
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0097 0.0669
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0155 0.0634 0.0626
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0138 0.0242
Loa Loa (eye worm) hypothetical protein 0.0065 0.0221 0.0316
Loa Loa (eye worm) cytochrome P450 family protein 0.006 0.0197 0.028
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0155 0.0634 0.1716
Loa Loa (eye worm) hypothetical protein 0.0038 0.0097 0.0132
Entamoeba histolytica hypothetical protein 0.0867 0.3914 0.8353
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0008 0.0000061935
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0138 0.1048
Brugia malayi Cytochrome P450 family protein 0.0028 0.0051 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.3354 0.7149
Entamoeba histolytica hypothetical protein 0.0396 0.1746 0.3697
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.0634 0.1308
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0157 0.1231
Trichomonas vaginalis conserved hypothetical protein 0.0438 0.1939 0.4111
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0155 0.0634 0.0626
Trichomonas vaginalis PIKK family atypical protein kinase 0.0718 0.3229 0.688
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0423 0.1868 0.3959
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0157 0.015
Loa Loa (eye worm) hypothetical protein 0.006 0.0198 0.0281
Trichomonas vaginalis PIKK family atypical protein kinase 0.068 0.3051 0.65
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0044 0.0036
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0097 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0025 0.0017
Entamoeba histolytica hypothetical protein 0.0043 0.012 0.0205
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1357 0.2861
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0086 0.0078
Trypanosoma brucei cytochrome P450, putative 0.0028 0.0051 0.0096
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0086 0.0078
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.0863 0.6743
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0155 0.0634 0.5656
Loa Loa (eye worm) phosphatidylinositol 3 0.0268 0.1155 0.1701
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0256 0.1101 0.1094
Schistosoma mansoni hypothetical protein 0.0019 0.0008 0.0000061935
Loa Loa (eye worm) phosphatidylinositol 3 0.1001 0.4534 0.6711
Trichomonas vaginalis PIKK family atypical protein kinase 0.081 0.3655 0.7796
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0286 0.1237 0.2715
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1238 0.2606
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0008 0.0008
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1649 0.752 0.7518
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0256 0.1101 0.2416
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0097 0.0089
Toxoplasma gondii FATC domain-containing protein 0.0396 0.1746 0.4767
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0256 0.1101 1
Brugia malayi Cytochrome P450 family protein 0.0019 0.0008 0.0008
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0839 0.3788 0.3783
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0423 0.1868 0.3959
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0893 0.4033 0.4028
Leishmania major phosphatidylinositol 3-kinase, putative 0.068 0.3051 0.6725
Mycobacterium ulcerans lipase LipD 0.0038 0.0097 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0008 0.0000061935
Trichomonas vaginalis PIKK family atypical protein kinase 0.0527 0.2349 0.4992
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0256 0.1101 0.1094
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0893 0.4033 0.4028
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0051 0.0043
Onchocerca volvulus 0.0155 0.0634 0.4752
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0097 0.0855
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0097 0.0155
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0273 0.0265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.0634 0.1308
Schistosoma mansoni hypothetical protein 0.0155 0.0634 0.0626
Loa Loa (eye worm) hypothetical protein 0.0322 0.1403 0.2068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0396 0.1746 0.3697
Leishmania major phosphatidylinositol 4-kinase, putative 0.0155 0.0634 0.1383
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0914 0.1909
Onchocerca volvulus 0.0155 0.0634 0.4752
Loa Loa (eye worm) phosphatidylinositol 3 0.0893 0.4033 0.5968
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0155 0.0634 0.5656
Mycobacterium ulcerans hypothetical protein 0.0038 0.0097 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.1033 0.4681 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0097 0.0155
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0423 0.1868 0.1868
Trichomonas vaginalis PIKK family atypical protein kinase 0.0827 0.3731 0.7959
Echinococcus granulosus neuropeptide s receptor 0.0568 0.2536 0.253
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0423 0.1868 0.3959
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0396 0.1746 0.174
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0155 0.0634 0.0626
Trichomonas vaginalis PIKK family atypical protein kinase 0.0827 0.3731 0.7959
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0155 0.0634 0.0626
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0155 0.0634 0.1383
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0867 0.3914 0.8353
Trichomonas vaginalis conserved hypothetical protein 0.0241 0.1033 0.2164
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.1357 0.2001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0396 0.1746 0.3697
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0051 0.0064
Onchocerca volvulus 0.0038 0.0097 0.0092
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.012 0.0113
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0438 0.1939 0.5295
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0256 0.1101 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0025 0.0025
Brugia malayi hypothetical protein 0.0027 0.0044 0.0044
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0878 0.3968 0.8468
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0512 0.2278 0.4838
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0718 0.3229 0.688
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0273 0.0393
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0086 0.0078
Loa Loa (eye worm) hypothetical protein 0.0038 0.0097 0.0132
Leishmania major hypothetical protein, conserved 0.0027 0.0044 0.008
Echinococcus granulosus serine protein kinase ATM 0.0396 0.1746 0.174
Echinococcus multilocularis 0.0155 0.0634 0.0626
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0256 0.1101 0.1094
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0155 0.0634 0.5656
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0155 0.0634 0.5656
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0273 0.0273
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0155 0.0634 0.0626
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0678 0.3045 0.3039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0762 0.343 0.7313
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0008 0.0008
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0155 0.0634 0.0626
Toxoplasma gondii target of rapamycin (TOR), putative 0.081 0.3655 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0097 0.0155
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0612 0.2738 0.6768
Trichomonas vaginalis PIKK family atypical protein kinase 0.081 0.3655 0.7796
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0863 0.18
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0155 0.0634 0.0626
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0678 0.3045 0.3045
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2188 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0051 0.0064
Toxoplasma gondii exonuclease III APE 0.0023 0.0025 0.0046
Entamoeba histolytica hypothetical protein 0.0043 0.012 0.0205
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0044 0.0036
Loa Loa (eye worm) hypothetical protein 0.0438 0.1939 0.2863
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0157 0.041
Brugia malayi N-terminal motif family protein 0.0218 0.0925 0.0925
Loa Loa (eye worm) hypothetical protein 0.0038 0.0097 0.0132
Trypanosoma cruzi target of rapamycin kinase 3 0.0827 0.3732 0.3727
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0051 0.0043
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0893 0.4033 0.8894
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0256 0.1101 0.2416
Trichomonas vaginalis PIKK family atypical protein kinase 0.0544 0.2426 0.5156
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1357 0.2861
Trichomonas vaginalis PIKK family atypical protein kinase 0.081 0.3655 0.7796
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1078 0.1587
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1033 0.4681 0.4677
Onchocerca volvulus 0.0286 0.1238 1
Mycobacterium tuberculosis Conserved protein 0.0038 0.0097 0.0855
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0097 1
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0097 0.0855
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0423 0.1868 0.1862
Trichomonas vaginalis PIKK family atypical protein kinase 0.022 0.0935 0.1954
Loa Loa (eye worm) beta-lactamase 0.0038 0.0097 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.068 0.3051 0.65
Trichomonas vaginalis PIKK family atypical protein kinase 0.1001 0.4534 0.9684
Schistosoma mansoni ap endonuclease 0.0023 0.0025 0.0017
Mycobacterium leprae Probable lipase LipE 0.0038 0.0097 0.1422
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0155 0.0634 0.1716
Leishmania major hypothetical protein, conserved 0.0155 0.0634 0.1383
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0044 0.0177
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0097 0.0155
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0097 0.0089
Mycobacterium tuberculosis Conserved protein 0.0038 0.0097 0.0855
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.0634 0.6011
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0086 0.0078
Loa Loa (eye worm) phosphatidylinositol 3 0.1483 0.6752 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0157 0.0285
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1033 0.4681 0.4677
Loa Loa (eye worm) hypothetical protein 0.0355 0.1557 0.2296
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0256 0.1101 0.2998
Loa Loa (eye worm) hypothetical protein 0.0038 0.0097 0.0132
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0396 0.1746 0.174
Loa Loa (eye worm) hypothetical protein 0.0148 0.0602 0.0881
Loa Loa (eye worm) hypothetical protein 0.0241 0.1033 0.1519
Entamoeba histolytica hypothetical protein 0.0155 0.0634 0.1308
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0086 0.0215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0893 0.4033 0.8608
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0025 0.0017
Toxoplasma gondii ABC1 family protein 0.0038 0.0097 0.0244
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0584 0.0855
Brugia malayi MH2 domain containing protein 0.0144 0.0584 0.0584
Echinococcus multilocularis neuropeptide receptor A26 0.0568 0.2536 0.253
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0863 0.18
Leishmania major phosphatidylinositol kinase related protein, putative 0.0155 0.0634 0.1383
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1001 0.4534 1
Schistosoma mansoni hypothetical protein 0.0175 0.0728 0.0721
Mycobacterium tuberculosis Conserved protein 0.0038 0.0097 0.0855
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0155 0.0634 0.0626
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0423 0.1868 0.3959
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0155 0.0634 0.0634
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0138 0.0281
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0025 0.0017
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0025 0.0017
Leishmania major hypothetical protein, conserved 0.0038 0.0097 0.0197
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0256 0.1101 0.1094
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0198 0.0281
Loa Loa (eye worm) phosphatidylinositol kinase 0.0155 0.0634 0.0928
Mycobacterium ulcerans beta-lactamase 0.0038 0.0097 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0025 0.5
Loa Loa (eye worm) hypothetical protein 0.0678 0.3045 0.4503
Schistosoma mansoni hypothetical protein 0.0175 0.0728 0.0721
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.0727 0.0727
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0863 0.18
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.3352 0.7146
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0097 0.0855
Trichomonas vaginalis esterase, putative 0.0038 0.0097 0.0155
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0086 0.0078
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0423 0.1868 0.1862
Schistosoma mansoni hypothetical protein 0.0019 0.0008 0.0000061935
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0198 0.0198
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0157 0.0285
Leishmania major phosphatidylinositol 3-kinase, putative 0.0256 0.1101 0.2416
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1649 0.752 0.7518
Brugia malayi hypothetical protein 0.0148 0.0602 0.0602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.3352 0.7146
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0256 0.1101 0.1094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0241 0.1033 0.2164
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0827 0.3732 0.8229
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0256 0.1101 0.1101
Loa Loa (eye worm) RNA binding protein 0.0076 0.0273 0.0393
Brugia malayi Cytochrome P450 family protein 0.006 0.0197 0.0197
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2188 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1357 0.2861
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0025 0.0025
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1357 0.2861
Brugia malayi hypothetical protein 0.0043 0.012 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.3354 0.7149
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0155 0.0634 0.0626
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.1033 0.4681 1
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0097 0.0855
Brugia malayi cytochrome P450 0.0019 0.0008 0.0008
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0423 0.1868 0.4111
Brugia malayi Pre-SET motif family protein 0.0251 0.1078 0.1078
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0097 0.0089
Echinococcus granulosus GPCR family 2 0.0019 0.0008 0.0000061935
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0155 0.0634 0.0634
Entamoeba histolytica hypothetical protein 0.0043 0.012 0.0205
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0097 0.0855
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.011 0.011
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0044 0.0177

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 22.3 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Inhibitors of DnaB-Intein Splicing Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2223, AID489010, AID492950] ChEMBL. No reference
AC50 (functional) = 107.9 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Non-Covalent Inhibitors of RecA-Intein Splicing Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2223, AID489010, AID492950] ChEMBL. No reference
EC50 (functional) = 87 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2097, AID2223, AID489010, AID492950] ChEMBL. No reference
Potency (functional) 1.4716 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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