Detailed information for compound 1313121

Basic information

Technical information
  • TDR Targets ID: 1313121
  • Name: N-(furan-2-ylmethyl)-2-[3-(furan-2-ylmethyl)- 4-oxoquinazolin-2-yl]sulfanylacetamide
  • MW: 395.432 | Formula: C20H17N3O4S
  • H donors: 1 H acceptors: 2 LogP: 2.35 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CSc1nc2ccccc2c(=O)n1Cc1ccco1)NCc1ccco1
  • InChi: 1S/C20H17N3O4S/c24-18(21-11-14-5-3-9-26-14)13-28-20-22-17-8-2-1-7-16(17)19(25)23(20)12-15-6-4-10-27-15/h1-10H,11-13H2,(H,21,24)
  • InChiKey: MJIQDEIRWMRZCB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-furylmethyl)-2-[3-(2-furylmethyl)-4-oxo-quinazolin-2-yl]sulfanyl-acetamide
  • N-(2-furylmethyl)-2-[[3-(2-furylmethyl)-4-oxo-2-quinazolinyl]thio]acetamide
  • N-(2-furylmethyl)-2-[[3-(2-furylmethyl)-4-keto-quinazolin-2-yl]thio]acetamide
  • N-(furan-2-ylmethyl)-2-[3-(furan-2-ylmethyl)-4-oxo-quinazolin-2-yl]sulfanyl-ethanamide
  • SMR000011616
  • EU-0027712
  • ZINC00887470
  • BAS 02914515
  • MLS000031070
  • N-Furan-2-ylmethyl-2-(3-furan-2-ylmethyl-4-oxo-3,4-dihydro-quinazolin-2-ylsulfanyl)-acetamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0064 0.1234
Schistosoma mansoni smad1 5 8 and 0.0032 0.0066 0.0214
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0035 0.0042
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0014 0.0013
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.009 0.2159
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.009 0.0131
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0116 0.0419 1
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0046 0.0237
Echinococcus granulosus mothers against decapentaplegic 5 0.0032 0.0066 0.0211
Loa Loa (eye worm) tubulin beta-1 chain 0.0024 0.0032 0.0164
Echinococcus multilocularis tar DNA binding protein 0.0192 0.0743 0.0742
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0318 0.1276 0.4114
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.0232 0.0743
Schistosoma mansoni hypothetical protein 0.0184 0.0707 0.2281
Schistosoma mansoni tubulin subunit beta 0.0024 0.0032 0.0102
Loa Loa (eye worm) prolyl oligopeptidase 0.0344 0.1384 0.718
Onchocerca volvulus Protein cycle homolog 0.0039 0.0094 0.0436
Brugia malayi beta-lactamase 0.0113 0.0408 0.2115
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0027 0.0046 0.0147
Onchocerca volvulus 0.0251 0.0991 0.7084
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0035 0.0048
Loa Loa (eye worm) tubulin beta-4 chain 0.0024 0.0032 0.0164
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0035 0.0042
Schistosoma mansoni tar DNA-binding protein 0.0192 0.0743 0.2395
Onchocerca volvulus 0.0032 0.0064 0.0216
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0081 0.008
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0113 0.0408 0.1315
Mycobacterium tuberculosis Probable esterase LipL 0.0113 0.0408 0.0646
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0035 0.0056
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.004 0.0101 0.0325
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1496 0.6251 1
Schistosoma mansoni tubulin subunit beta 0.0024 0.0032 0.0102
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.075 0.3101 1
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0.0101 0.1018
Loa Loa (eye worm) hypothetical protein 0.0113 0.0408 0.2115
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0081 0.0816
Echinococcus granulosus Tubulin beta 2C chain 0.0024 0.0032 0.0098
Echinococcus multilocularis aryl hydrocarbon receptor 0.0055 0.0163 0.0162
Plasmodium vivax ataxin-2 like protein, putative 0.0079 0.0265 0.643
Trypanosoma cruzi oligopeptidase b 0.0027 0.0046 0.1089
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0131 0.013
Leishmania major beta tubulin 0.0024 0.0032 0.0753
Toxoplasma gondii hypothetical protein 0.0027 0.0046 0.078
Schistosoma mansoni alpha-glucosidase 0.0138 0.0514 0.1656
Brugia malayi RNA recognition motif domain containing protein 0.0192 0.0743 0.3853
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0032 0.0066 0.0065
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.004 0.0101 0.0321
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0318 0.1276 0.4111
Trypanosoma brucei beta tubulin 0.0024 0.0032 0.0433
Mycobacterium ulcerans hypothetical protein 0.0025 0.0035 0.0042
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0039 0.0094 0.0486
Brugia malayi hypothetical protein 0.0039 0.0094 0.0486
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.0608 0.3155
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0318 0.1276 0.1275
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.0014 0.014
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0113 0.0408 0.0646
Loa Loa (eye worm) tubulin beta-2A chain 0.0024 0.0032 0.0164
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0046 0.0237
Echinococcus multilocularis neuropeptide s receptor 0.0454 0.1849 0.1848
Schistosoma mansoni hypothetical protein 0.0048 0.0131 0.0423
Leishmania major beta tubulin 0.0024 0.0032 0.0753
Giardia lamblia Beta tubulin 0.0024 0.0032 0.2021
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0014 0.0335
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0014 0.0335
Mycobacterium leprae conserved hypothetical protein 0.0113 0.0408 0.0652
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0081 0.0816
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0081 0.0816
Mycobacterium tuberculosis Conserved protein 0.0113 0.0408 0.0646
Loa Loa (eye worm) pigment dispersing factor receptor c 0.015 0.0565 0.2933
Brugia malayi Ets-domain containing protein 0.0071 0.0232 0.1202
Schistosoma mansoni ap endonuclease 0.004 0.0098 0.0317
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0116 0.0419 1
Brugia malayi hypothetical protein 0.0088 0.0304 0.1577
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0044
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0172 0.055
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0172 0.0171
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.009 0.1887
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0.0101 0.1018
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.004 0.0101 0.01
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0542 0.0861
Loa Loa (eye worm) fli-1 protein 0.0216 0.0845 0.4383
Trichomonas vaginalis penicillin-binding protein, putative 0.0113 0.0408 0.4117
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0081 0.0816
Schistosoma mansoni smad1 5 8 and 0.0032 0.0066 0.0214
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0055 0.0163 0.0847
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0098 0.0097
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0408 0.4117
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.009 0.0288
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0542 0.0861
Mycobacterium tuberculosis Probable lipase LipE 0.0113 0.0408 0.0646
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.0232 0.1202
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0035 0.0048
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0098 1
Brugia malayi MH2 domain containing protein 0.0032 0.0066 0.0345
Loa Loa (eye worm) MH2 domain-containing protein 0.0473 0.1928 1
Echinococcus multilocularis smad 0.0032 0.0066 0.0065
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.0608 0.3155
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.0608 0.1958
Schistosoma mansoni inositol monophosphatase 0.0038 0.009 0.0292
Echinococcus multilocularis tumor protein p63 0.0333 0.1339 0.1338
Loa Loa (eye worm) hypothetical protein 0.015 0.0565 0.2933
Onchocerca volvulus 0.0093 0.0322 0.2131
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0081 0.1928
Leishmania major beta tubulin 0.0024 0.0032 0.0753
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0064 0.0206
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0027 0.0046 0.078
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.0014 0.0218
Trypanosoma brucei PAB1-binding protein , putative 0.0079 0.0265 0.62
Onchocerca volvulus Prolyl endopeptidase homolog 0.0027 0.0046 0.008
Echinococcus multilocularis tubulin subunit beta 0.0024 0.0032 0.003
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.002 0.0014 0.0016
Trypanosoma cruzi PAB1-binding protein , putative 0.0079 0.0265 0.6328
Echinococcus granulosus tubulin beta 4A class IVa 0.0024 0.0032 0.0098
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0184 0.0707 0.0706
Brugia malayi TAR-binding protein 0.0192 0.0743 0.3853
Onchocerca volvulus 0.0113 0.0408 0.2764
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0014 0.0335
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0014 0.0335
Trichomonas vaginalis tubulin epsilon chain, putative 0.0024 0.0032 0.0319
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0113 0.0408 0.2115
Echinococcus granulosus neuropeptide receptor A26 0.0454 0.1849 0.596
Onchocerca volvulus 0.004 0.0101 0.0489
Brugia malayi prolyl oligopeptidase family protein 0.0027 0.0046 0.0237
Leishmania major oligopeptidase b 0.0027 0.0046 0.1089
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0035 0.0181
Mycobacterium ulcerans TetR family transcriptional regulator 0.1496 0.6251 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0035 0.0048
Loa Loa (eye worm) hypothetical protein 0.015 0.0564 0.2924
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0098 0.0144
Leishmania major beta tubulin 0.0024 0.0032 0.0753
Leishmania major beta tubulin 0.0024 0.0032 0.0753
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.004 0.0101 0.2405
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0014 0.0335
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.075 0.3101 0.3101
Schistosoma mansoni hypothetical protein 0.0048 0.0131 0.0423
Trichomonas vaginalis tubulin, putative 0.0024 0.0032 0.0319
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0318 0.1276 0.4114
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0081 0.0728
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0131 0.0681
Echinococcus granulosus Tubulin beta 2C chain 0.0024 0.0032 0.0098
Trypanosoma brucei hypothetical protein, conserved 0.0113 0.0408 0.972
Brugia malayi Tubulin beta-1 chain 0.0024 0.0032 0.0164
Onchocerca volvulus 0.0055 0.0162 0.0944
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0098 0.2347
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.004 0.0101 0.1018
Echinococcus granulosus tumor protein p63 0.0333 0.1339 0.4314
Trypanosoma brucei beta tubulin 0.0024 0.0032 0.0433
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0101 0.1018
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0113 0.0408 0.1315
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0098 0.2252
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0081 0.0816
Onchocerca volvulus 0.0113 0.0408 0.2764
Loa Loa (eye worm) prolyl oligopeptidase 0.0027 0.0046 0.0237
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0098 0.051
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0046 0.1089
Brugia malayi hypothetical protein 0.015 0.0564 0.2924
Echinococcus multilocularis Tubulin beta 2C chain 0.0024 0.0032 0.003
Toxoplasma gondii prolyl endopeptidase 0.0027 0.0046 0.078
Plasmodium falciparum thioredoxin reductase 0.0057 0.0172 0.6359
Trypanosoma brucei oligopeptidase b 0.0027 0.0046 0.078
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1496 0.6251 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0044
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0008 0.6001
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0064 0.0203
Schistosoma mansoni hypothetical protein 0.0205 0.0795 0.2564
Loa Loa (eye worm) hypothetical protein 0.0048 0.0131 0.0681
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.009 0.0089
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.004 0.0101 0.1025
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.0862 0.4471
Leishmania major trypanothione reductase 0.0057 0.0172 0.4097
Brugia malayi Inositol-1 0.0038 0.009 0.0469
Toxoplasma gondii beta tubulin 0.0024 0.0032 0.0433
Mycobacterium tuberculosis Probable hydrolase 0.0113 0.0408 0.0646
Schistosoma mansoni hypothetical protein 0.0036 0.0081 0.026
Brugia malayi hypothetical protein 0.0236 0.0929 0.4821
Echinococcus granulosus beta LACTamase domain containing family member 0.0113 0.0408 0.1312
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0046 0.0461
Echinococcus multilocularis beta LACTamase domain containing family member 0.0113 0.0408 0.0407
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.0481 0.0769
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0542 0.0867
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0344 0.1384 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0722 0.298 0.4764
Echinococcus granulosus tubulin beta 1 chain 0.0024 0.0032 0.0098
Leishmania major hypothetical protein, conserved 0.0079 0.0265 0.6328
Brugia malayi Calcitonin receptor-like protein seb-1 0.015 0.0565 0.2933
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.0608 0.0607
Brugia malayi Pre-SET motif family protein 0.022 0.0862 0.4471
Brugia malayi hypothetical protein 0.0184 0.0707 0.367
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0131 0.042
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0098 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.0408 0.2115
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.009 0.0913
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0064 0.0206
Echinococcus granulosus beta tubulin 0.0024 0.0032 0.0098
Plasmodium falciparum ataxin-2 like protein, putative 0.0079 0.0265 1
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.004 0.0101 0.1025
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0113 0.0408 0.2115
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0014 0.0335
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0172 0.0891
Brugia malayi beta-lactamase family protein 0.0113 0.0408 0.2115
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0044
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0116 0.0419 1
Loa Loa (eye worm) inositol-1 0.0038 0.009 0.0469
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0081 0.0419
Loa Loa (eye worm) MH2 domain-containing protein 0.0032 0.0066 0.0345
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0032 0.0066 0.0214
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0344 0.1384 0.1383
Brugia malayi beta-lactamase family protein 0.0113 0.0408 0.2115
Toxoplasma gondii exonuclease III APE 0.004 0.0098 0.2082
Echinococcus granulosus beta tubulin 0.0024 0.0032 0.0098
Echinococcus granulosus neuropeptide s receptor 0.0454 0.1849 0.596
Toxoplasma gondii beta-tubulin, putative 0.0024 0.0032 0.0433
Leishmania major beta tubulin 0.0024 0.0032 0.0753
Echinococcus granulosus geminin 0.0205 0.0795 0.2561
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0098 0.0993
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0027 0.0046 0.0147
Echinococcus granulosus acylamino acid releasing enzyme 0.0027 0.0046 0.0143
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.009 0.0913
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0014 0.0045
Loa Loa (eye worm) hypothetical protein 0.004 0.0101 0.0523
Echinococcus multilocularis mothers against decapentaplegic 5 0.0032 0.0066 0.0065
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0172 0.4089
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0.0101 0.1018
Echinococcus multilocularis neuropeptide receptor A26 0.0454 0.1849 0.1848
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0.0101 0.1018
Brugia malayi Serine protease Z688.6 precursor 0.004 0.0101 0.0523
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.0608 0.0607
Echinococcus multilocularis beta tubulin 0.0024 0.0032 0.003
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0027 0.0046 0.0208
Brugia malayi MH2 domain containing protein 0.0032 0.0066 0.0345
Schistosoma mansoni tar DNA-binding protein 0.0192 0.0743 0.2395
Mycobacterium ulcerans transcriptional regulator 0.1496 0.6251 1
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0027 0.0046 0.0066
Echinococcus multilocularis acylamino acid releasing enzyme 0.0027 0.0046 0.0044
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.0014 0.014
Entamoeba histolytica hypothetical protein 0.0184 0.0707 1
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0027 0.0046 0.1089
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0481 0.0763
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0481 0.0763
Toxoplasma gondii ABC1 family protein 0.0113 0.0408 0.972
Mycobacterium ulcerans esterase/lipase LipP 0.0113 0.0408 0.064
Leishmania major beta tubulin 0.0024 0.0032 0.0753
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0131 0.013
Leishmania major beta tubulin 0.0024 0.0032 0.0753
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0027 0.0046 0.0147
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0318 0.1276 0.4111
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0029
Schistosoma mansoni ets-related 0.0216 0.0845 0.2724
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0081 0.0256
Trypanosoma cruzi prolyl endopeptidase 0.0027 0.0046 0.1089
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0027 0.0046 0.1089
Schistosoma mansoni Smad4 0.0032 0.0066 0.0214
Brugia malayi MH1 domain containing protein 0.0032 0.0066 0.0345
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0098 0.3503
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0039 0.0094 0.0486
Mycobacterium tuberculosis Probable peptidase 0.0027 0.0046 0.0066
Loa Loa (eye worm) BEN-1 protein 0.0024 0.0032 0.0164
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0008 0.0007
Trichomonas vaginalis mercuric reductase, putative 0.002 0.0014 0.0142
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0014 0.0335
Brugia malayi MH1 domain containing protein 0.0018 0.0006 0.0029
Schistosoma mansoni hypothetical protein 0.0048 0.0134 0.0433
Schistosoma mansoni ap endonuclease 0.004 0.0098 0.0317
Mycobacterium ulcerans flavoprotein disulfide reductase 0.002 0.0014 0.0009
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0014 0.0335
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.009 0.0913
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0081 0.1928
Loa Loa (eye worm) hypothetical protein 0.0027 0.0046 0.0237
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0172 0.0268
Loa Loa (eye worm) hypothetical protein 0.0103 0.0364 0.1891
Brugia malayi Pre-SET motif family protein 0.0032 0.0064 0.0332
Loa Loa (eye worm) hypothetical protein 0.004 0.0101 0.0523
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0014 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.009 0.1887
Loa Loa (eye worm) hypothetical protein 0.0236 0.0929 0.4821
Echinococcus granulosus smad 0.0032 0.0066 0.0211
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0344 0.1384 0.4463
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0101 0.1018
Onchocerca volvulus 0.0048 0.0134 0.0736
Plasmodium falciparum tubulin beta chain 0.0024 0.0032 0.0901
Mycobacterium ulcerans beta-lactamase 0.0113 0.0408 0.064
Leishmania major beta tubulin 0.0024 0.0032 0.0753
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0131 0.042
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.0408 0.9729
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0044
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0098 0.0151
Loa Loa (eye worm) hypothetical protein 0.0113 0.0408 0.2115
Echinococcus granulosus Tubulin beta 2C chain 0.0024 0.0032 0.0098
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0035 0.0056
Mycobacterium tuberculosis Probable lipase LipD 0.0113 0.0408 0.0646
Loa Loa (eye worm) MH1 domain-containing protein 0.0032 0.0066 0.0345
Plasmodium vivax SET domain protein, putative 0.0032 0.0064 0.1392
Brugia malayi MH2 domain containing protein 0.0473 0.1928 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.002 0.0014 0.0009
Entamoeba histolytica hypothetical protein, conserved 0.0027 0.0046 0.0208
Giardia lamblia Beta tubulin 0.0024 0.0032 0.2021
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0035 0.0042
Schistosoma mansoni inositol monophosphatase 0.0038 0.009 0.0292
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0098 0.0993
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0027 0.0046 0.078
Schistosoma mansoni smad1 5 8 and 0.0032 0.0066 0.0214
Brugia malayi Serine carboxypeptidase S28 family protein 0.004 0.0101 0.0523
Loa Loa (eye worm) hypothetical protein 0.0032 0.0064 0.0332
Entamoeba histolytica hypothetical protein 0.0184 0.0707 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0134 0.0696
Trypanosoma cruzi serine carboxypeptidase S28, putative 0.004 0.0101 0.2405
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0035 0.0049
Onchocerca volvulus 0.0113 0.0408 0.2764
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0113 0.0408 0.0646
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0098 0.2082
Brugia malayi RNA binding protein 0.0192 0.0743 0.3853
Plasmodium vivax tubulin beta chain, putative 0.0024 0.0032 0.058
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0081 0.0816
Echinococcus multilocularis geminin 0.0205 0.0795 0.0794
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0014 0.0073
Mycobacterium tuberculosis Conserved protein 0.0113 0.0408 0.0646
Leishmania major beta tubulin 0.0024 0.0032 0.0753
Trypanosoma brucei prolyl endopeptidase 0.0027 0.0046 0.078
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0318 0.1276 0.6618
Trypanosoma cruzi putative prolyl carboxypeptidase, putative 0.004 0.0101 0.2405
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0098 0.9718
Mycobacterium ulcerans hypothetical protein 0.0113 0.0408 0.064
Loa Loa (eye worm) hypothetical protein 0.0025 0.0035 0.0181
Schistosoma mansoni transcription factor LCR-F1 0.0184 0.0707 0.2281
Echinococcus granulosus Tubulin beta 2C chain 0.0024 0.0032 0.0098
Onchocerca volvulus 0.015 0.0564 0.3919
Schistosoma mansoni hypothetical protein 0.0103 0.0364 0.1175
Loa Loa (eye worm) BEN-1 protein 0.0024 0.0032 0.0164
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0.0101 0.1018
Giardia lamblia Thymus-specific serine protease precursor 0.004 0.0101 1
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0046 0.0208
Loa Loa (eye worm) hypothetical protein 0.0025 0.0035 0.0181
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0064 0.0063
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0.0101 0.1018
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0035 0.0181
Loa Loa (eye worm) hypothetical protein 0.0027 0.0046 0.0237
Leishmania major beta tubulin 0.0024 0.0032 0.0753
Brugia malayi hypothetical protein 0.0079 0.0265 0.1376
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0081 0.1928
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0035 0.0042
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0.0101 0.1018
Brugia malayi hypothetical protein 0.0051 0.0147 0.076
Leishmania major beta tubulin 0.0024 0.0032 0.0753
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0172 0.4097
Trichomonas vaginalis tubulin beta chain, putative 0.0024 0.0032 0.0319
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.009 0.0872
Echinococcus granulosus TGF beta signal transducer SmadC 0.0032 0.0066 0.0211
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0542 0.0861
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0024 0.0032 0.003
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.009 0.2159
Brugia malayi hypothetical protein 0.0038 0.0093 0.048
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.009 0.2159
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0098 0.0988
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0027 0.0046 0.1089
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0027 0.0046 0.0461
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0081 0.0816
Schistosoma mansoni tubulin subunit beta 0.0024 0.0032 0.0102
Loa Loa (eye worm) TAR-binding protein 0.0192 0.0743 0.3853
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0.0101 0.1018
Schistosoma mansoni aryl hydrocarbon receptor 0.0017 0.0001 0.0004
Schistosoma mansoni tubulin subunit beta 0.0024 0.0032 0.0102
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0098 0.2347
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0408 0.4117
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0027 0.0046 0.006
Schistosoma mansoni tar DNA-binding protein 0.0192 0.0743 0.2395
Trichomonas vaginalis set domain proteins, putative 0.0251 0.0991 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.015 0.0565 0.2933
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0116 0.0419 1
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.0929 0.0928
Mycobacterium leprae Probable lipase LipE 0.0113 0.0408 0.0652
Loa Loa (eye worm) hypothetical protein 0.004 0.0101 0.0523
Loa Loa (eye worm) hypothetical protein 0.0113 0.0408 0.2115
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0027 0.0046 0.0073
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0113 0.0408 0.0646
Loa Loa (eye worm) hypothetical protein 0.0025 0.0035 0.0181
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0074 0.0111
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0116 0.0419 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0162 0.0841
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0318 0.1276 0.1275
Loa Loa (eye worm) hypothetical protein 0.0079 0.0265 0.1376
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.0364 0.1891
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0035 0.083
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0014 0.0042
Loa Loa (eye worm) hypothetical protein 0.0038 0.0093 0.048
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0081 0.1648
Loa Loa (eye worm) hypothetical protein 0.0027 0.0046 0.0237
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0027 0.0046 0.078
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0064 0.0206
Echinococcus multilocularis prolyl endopeptidase 0.0027 0.0046 0.0044
Brugia malayi prolyl oligopeptidase family protein 0.0116 0.0419 0.2174
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0035 0.083
Entamoeba histolytica serine carboxypeptidase (S28) family protein 0.004 0.0101 0.1025
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0081 0.0257
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0131 0.0681
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0027 0.0046 0.0208
Loa Loa (eye worm) hypothetical protein 0.0038 0.0093 0.048
Trypanosoma brucei beta tubulin 0.0024 0.0032 0.0433
Toxoplasma gondii LsmAD domain-containing protein 0.0079 0.0265 0.62
Plasmodium falciparum ataxin-2 like protein, putative 0.0079 0.0265 1
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0046 0.0208
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0318 0.1276 0.4114
Loa Loa (eye worm) Smad1 0.0032 0.0066 0.0345
Brugia malayi MH1 domain containing protein 0.0032 0.0066 0.0345
Plasmodium vivax glutathione reductase, putative 0.0057 0.0172 0.4089
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0046 0.0932
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0408 0.4117
Toxoplasma gondii serine carboxypeptidase s28 protein 0.004 0.0101 0.2142
Brugia malayi hypothetical protein 0.0055 0.0162 0.0841
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0035 0.0181
Brugia malayi Serine protease Z688.6 precursor 0.004 0.0101 0.0523
Brugia malayi Fli-1 protein 0.0216 0.0845 0.4383
Schistosoma mansoni alpha-glucosidase 0.0138 0.0514 0.1656
Plasmodium falciparum thioredoxin reductase 0.002 0.0014 0.0218
Brugia malayi Smad1 0.0032 0.0066 0.0345
Trypanosoma cruzi beta tubulin, putative 0.0024 0.0032 0.0753
Loa Loa (eye worm) hypothetical protein 0.0113 0.0408 0.2115
Loa Loa (eye worm) hypothetical protein 0.0038 0.0093 0.048
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0064 0.0063
Leishmania major beta tubulin 0.0024 0.0032 0.0753
Trichomonas vaginalis tubulin gamma chain, putative 0.0024 0.0032 0.0319
Plasmodium vivax hypothetical protein, conserved 0.0113 0.0408 1
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0039 0.0094 0.0486
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0081 0.0816
Echinococcus granulosus aryl hydrocarbon receptor 0.0055 0.0163 0.0523
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0116 0.0419 0.1351
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0.0101 0.1018
Loa Loa (eye worm) hypothetical protein 0.0113 0.0408 0.2115
Loa Loa (eye worm) tubulin beta chain 0.0024 0.0032 0.0164
Onchocerca volvulus 0.0049 0.0137 0.0754
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0.0101 0.1018
Trichomonas vaginalis lysosomal pro-X carboxypeptidase, putative 0.004 0.0101 0.1018
Leishmania major beta tubulin 0.0024 0.0032 0.0753
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.0408 0.9729
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0014 0.0335
Mycobacterium tuberculosis Conserved protein 0.0113 0.0408 0.0646
Trichomonas vaginalis esterase, putative 0.0113 0.0408 0.4117
Trypanosoma brucei prolyl oligopeptidase, putative 0.0027 0.0046 0.078
Toxoplasma gondii thioredoxin reductase 0.0057 0.0172 0.3892
Schistosoma mansoni hypothetical protein 0.0205 0.0795 0.2564
Schistosoma mansoni survival motor neuron protein 0.0048 0.0134 0.0433
Loa Loa (eye worm) hypothetical protein 0.0088 0.0304 0.1577
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0131 0.0681
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0044
Entamoeba histolytica prolyl oligopeptidase family protein 0.0027 0.0046 0.0208
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0081 0.0816
Plasmodium falciparum glutathione reductase 0.0057 0.0172 0.6359
Trypanosoma brucei trypanothione reductase 0.0057 0.0172 0.3892
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0027 0.0046 0.0461
Echinococcus multilocularis Tubulin beta 2C chain 0.0024 0.0032 0.003
Trichomonas vaginalis tubulin epsilon chain, putative 0.0024 0.0032 0.0319
Brugia malayi prolyl oligopeptidase family protein 0.0344 0.1384 0.718
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0059 0.0187
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0027 0.0046 0.1089
Loa Loa (eye worm) hypothetical protein 0.0061 0.0188 0.0975
Echinococcus granulosus Dipeptidyl peptidase 9 0.0116 0.0419 0.1348
Loa Loa (eye worm) beta-tubulin 0.0024 0.0032 0.0164
Loa Loa (eye worm) hypothetical protein 0.0049 0.0137 0.0708
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0035 0.0049
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0014 0.0335
Trypanosoma cruzi oligopeptidase b 0.0027 0.0046 0.1089
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0046 0.1089
Giardia lamblia Serine peptidase, putative 0.004 0.0101 1
Entamoeba histolytica hypothetical protein 0.0184 0.0707 1
Mycobacterium ulcerans lipase LipD 0.0113 0.0408 0.064
Leishmania major beta tubulin 0.0024 0.0032 0.0753
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0344 0.1384 0.4461
Schistosoma mansoni smad 0.0032 0.0066 0.0214
Leishmania major beta tubulin 0.0024 0.0032 0.0753
Brugia malayi Ets-domain containing protein 0.0071 0.0232 0.1202
Brugia malayi glutathione reductase 0.0057 0.0172 0.0891
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0035 0.0042
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0074 0.0118
Loa Loa (eye worm) hypothetical protein 0.004 0.0101 0.0523
Echinococcus granulosus GPCR family 2 0.0048 0.0131 0.042
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0.0101 0.1018
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0481 0.0763
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0014 0.0335
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.0232 0.0231
Schistosoma mansoni tubulin subunit beta 0.0024 0.0032 0.0102
Giardia lamblia Alanyl dipeptidyl peptidase 0.0027 0.0046 0.3641
Echinococcus multilocularis Tubulin beta 2C chain 0.0024 0.0032 0.003
Schistosoma mansoni tubulin subunit beta 0.0024 0.0032 0.0102
Trypanosoma brucei beta tubulin 0.0024 0.0032 0.0433
Trichomonas vaginalis Clan SC, family S28, unassigned serine peptidase 0.004 0.0101 0.1018
Leishmania major hypothetical protein, conserved 0.0113 0.0408 0.9729
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0035 0.0042
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.002 0.0014 0.0009
Trypanosoma cruzi PAB1-binding protein , putative 0.0079 0.0265 0.6328
Schistosoma mansoni tar DNA-binding protein 0.0192 0.0743 0.2395
Echinococcus multilocularis tubulin beta 1 chain 0.0024 0.0032 0.003
Trichomonas vaginalis penicillin-binding protein, putative 0.0113 0.0408 0.4117
Echinococcus granulosus Smad4 0.0032 0.0066 0.0211
Echinococcus granulosus tar DNA binding protein 0.0192 0.0743 0.2392
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0192 0.0743 0.3853
Brugia malayi Thioredoxin reductase 0.0057 0.0172 0.0891
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0081 0.0728
Echinococcus multilocularis Tubulin beta 2C chain 0.0024 0.0032 0.003
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0113 0.0408 0.064
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0116 0.0419 1
Echinococcus multilocularis Smad4 0.0032 0.0066 0.0065
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.075 0.3101 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.0014 0.0218
Trypanosoma brucei glucosidase, putative 0.0036 0.0081 0.1648
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0481 0.0763
Trichomonas vaginalis prolylcarboxypeptidase, putative 0.004 0.0101 0.1018
Trichomonas vaginalis glutathione reductase, putative 0.002 0.0014 0.0142
Plasmodium falciparum glutathione reductase 0.002 0.0014 0.0218
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0027 0.0046 0.0147
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0014 0.0335
Schistosoma mansoni gabp alpha 0.0071 0.0232 0.0747
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.009 0.9065
Loa Loa (eye worm) hypothetical protein 0.0038 0.0093 0.048
Giardia lamblia Beta tubulin 0.0024 0.0032 0.2021
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0184 0.0707 0.2278
Loa Loa (eye worm) glutathione reductase 0.0057 0.0172 0.0891
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0137 0.044
Leishmania major beta tubulin 0.0024 0.0032 0.0753
Plasmodium falciparum peptidase, putative 0.0027 0.0046 0.1449
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0116 0.0419 0.0418
Echinococcus multilocularis GPCR, family 2 0.0048 0.0131 0.013
Echinococcus multilocularis Tubulin beta 2C chain 0.0024 0.0032 0.003
Echinococcus granulosus tubulin subunit beta 0.0024 0.0032 0.0098
Echinococcus multilocularis beta tubulin 0.0024 0.0032 0.003
Giardia lamblia Alanyl dipeptidyl peptidase 0.0027 0.0046 0.3641
Schistosoma mansoni alpha glucosidase 0.0036 0.0081 0.0261
Loa Loa (eye worm) beta-lactamase 0.0113 0.0408 0.2115
Trichomonas vaginalis tubulin alpha chain, putative 0.0024 0.0032 0.0319
Brugia malayi beta-tubulin, identical 0.0024 0.0032 0.0164
Entamoeba histolytica hypothetical protein 0.0184 0.0707 1
Loa Loa (eye worm) transcription factor SMAD2 0.0473 0.1928 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0081 0.0419
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0035 0.0042
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0098 0.2347
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0039 0.0094 0.0302
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.0929 0.2994
Loa Loa (eye worm) RNA binding protein 0.0192 0.0743 0.3853
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0098 0.0314
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0038 0.0093 0.048
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0098 0.051
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1496 0.6251 1
Schistosoma mansoni hypothetical protein 0.0048 0.0131 0.0423
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0318 0.1276 0.6618
Schistosoma mansoni tar DNA-binding protein 0.0192 0.0743 0.2395
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0035 0.083
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0481 0.0763
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0014 0.0335
Leishmania major beta tubulin 0.0024 0.0032 0.0753
Brugia malayi MH1 domain containing protein 0.0018 0.0006 0.0029
Echinococcus granulosus Tubulin beta 2C chain 0.0024 0.0032 0.0098
Toxoplasma gondii beta-1 tubulin, putative 0.0024 0.0032 0.0433
Loa Loa (eye worm) nuclear factor I 0.0018 0.0006 0.0029
Schistosoma mansoni hypothetical protein 0.0048 0.0131 0.0423
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0064 0.0206
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0081 0.0079
Echinococcus granulosus prolyl endopeptidase 0.0027 0.0046 0.0143
Mycobacterium tuberculosis Probable reductase 0.013 0.0481 0.0763

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 95.2834 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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