Detailed information for compound 1316730

Basic information

Technical information
  • TDR Targets ID: 1316730
  • Name: 5,6-dimethyl-2-(2-oxo-2-pyrrolidin-1-ylethyl) -3H-thieno[3,2-e]pyrimidin-4-one
  • MW: 291.369 | Formula: C14H17N3O2S
  • H donors: 1 H acceptors: 4 LogP: 2.22 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCCC1)Cc1nc(O)c2c(n1)sc(c2C)C
  • InChi: 1S/C14H17N3O2S/c1-8-9(2)20-14-12(8)13(19)15-10(16-14)7-11(18)17-5-3-4-6-17/h3-7H2,1-2H3,(H,15,16,19)
  • InChiKey: YTJFFKTXKSMKPD-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 5,6-dimethyl-2-(2-oxo-2-pyrrolidin-1-yl-ethyl)-3H-thieno[3,2-e]pyrimidin-4-one
  • 5,6-dimethyl-2-(2-oxo-2-1-pyrrolidinylethyl)-3H-thieno[3,2-e]pyrimidin-4-one
  • 2-(2-keto-2-pyrrolidin-1-yl-ethyl)-5,6-dimethyl-3H-thieno[3,2-e]pyrimidin-4-one
  • ZINC03293558
  • MLS001002315
  • SMR000368841
  • T0520-5913

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0488 0.5844
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0028 0.0824 0.3036
Trypanosoma brucei NADH-cytochrome b5 reductase-like protein 0.0008 0.0001 0.0003
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0835 1
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0008 0.0001 0.0003
Entamoeba histolytica hypothetical protein 0.0088 0.328 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0835 0.3076
Trypanosoma cruzi reductase, putative 0.0008 0.0001 0.0003
Trichomonas vaginalis sulfite reductase, putative 0.0074 0.2715 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0835 0.0835
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0008 0.0001 0.0003
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0028 0.0824 0.3036
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0008 0.0001 0.0003
Onchocerca volvulus 0.0008 0.0001 0.0011
Mycobacterium ulcerans electron transfer protein FdxB 0.0008 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0087 0.3243 0.3243
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0591 0.0591
Echinococcus granulosus hypothetical protein 0.0059 0.2079 0.2079
Leishmania major NADH-dependent fumarate reductase-like protein 0.0008 0.0001 0.0003
Echinococcus multilocularis cytochrome b5 reductase 4 0.0008 0.0001 0.0001
Schistosoma mansoni serine/threonine protein kinase 0.006 0.2116 0.2116
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0074 0.2715 0.8276
Leishmania major oxidoreductase-like protein 0.0008 0.0001 0.0003
Mycobacterium ulcerans monooxygenase 0.0008 0.0001 0.0004
Loa Loa (eye worm) cytochrome b5 reductase 4 0.0008 0.0001 0.0001
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0835 0.2546
Trypanosoma cruzi p450 reductase, putative 0.0008 0.0001 0.0003
Plasmodium falciparum ferredoxin--NADP reductase 0.0008 0.0001 0.0004
Trypanosoma brucei oxidoreductase-protein, putative 0.0008 0.0001 0.0003
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0074 0.2715 0.8276
Loa Loa (eye worm) diaphorase 0.0008 0.0001 0.0001
Brugia malayi diaphorase 0.0008 0.0001 0.0002
Onchocerca volvulus 0.0029 0.0835 1
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0008 0.0001 0.0011
Loa Loa (eye worm) hypothetical protein 0.012 0.4606 0.4606
Loa Loa (eye worm) FAD binding domain-containing protein 0.0074 0.2715 0.2715
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0591 0.0591
Loa Loa (eye worm) hypothetical protein 0.0021 0.0536 0.0536
Echinococcus multilocularis NADH cytochrome b5 reductase 3 0.0008 0.0001 0.0001
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0008 0.0001 0.0003
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0835 0.1813
Mycobacterium ulcerans oxygenase 0.0008 0.0001 0.0004
Echinococcus multilocularis dual specificity protein kinase clk2 0.006 0.2116 0.2116
Leishmania major NADH-cytochrome b5 reductase, putative 0.0008 0.0001 0.0003
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0591 0.2176
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.006 0.2116 0.6452
Brugia malayi FAD binding domain containing protein 0.0046 0.1543 0.3351
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.448 0.448
Loa Loa (eye worm) hypothetical protein 0.0021 0.0536 0.0536
Leishmania major hypothetical protein, conserved 0.0028 0.0824 0.2512
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0488 0.5844
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0008 0.0001 0.0003
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.006 0.2116 0.6452
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0008 0.0001 0.0003
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0591 0.1282
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0008 0.0001 0.0003
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0028 0.0824 0.3036
Echinococcus granulosus dual specificity protein kinase clk2 0.006 0.2116 0.2116
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0835 0.3076
Trypanosoma brucei NADH-dependent fumarate reductase 0.0008 0.0001 0.0003
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0835 0.1813
Echinococcus granulosus methionine synthase reductase 0.0046 0.1543 0.1543
Loa Loa (eye worm) hypothetical protein 0.0029 0.0835 0.0835
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0591 0.7073
Leishmania major protein kinase, putative 0.006 0.2116 0.6452
Entamoeba histolytica type A flavoprotein, putative 0.0028 0.0824 0.2512
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.006 0.2116 1
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0008 0.0001 0.0003
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0536 0.1975
Brugia malayi MH2 domain containing protein 0.0117 0.448 0.9726
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0008 0.0001 0.0003
Plasmodium falciparum protein serine/threonine kinase-1 0.006 0.2116 0.7796
Loa Loa (eye worm) hypothetical protein 0.0074 0.2715 0.2715
Entamoeba histolytica type A flavoprotein, putative 0.0028 0.0824 0.2512
Loa Loa (eye worm) hypothetical protein 0.0059 0.2079 0.2079
Loa Loa (eye worm) FAD binding domain-containing protein 0.0046 0.1543 0.1543
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0088 0.328 0.328
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.328 0.328
Mycobacterium ulcerans hypothetical protein 0.0029 0.0835 0.3076
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0074 0.2715 0.8276
Mycobacterium tuberculosis Probable oxidoreductase 0.0008 0.0001 0.0011
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0028 0.0824 0.3036
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0028 0.0824 0.2512
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0028 0.0824 0.2512
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0088 0.328 1
Leishmania major cytochrome-b5 reductase, putative 0.0008 0.0001 0.0003
Mycobacterium tuberculosis Hypothetical oxidoreductase 0.0008 0.0001 0.0011
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0074 0.2715 0.8276
Mycobacterium ulcerans flavodoxin oxidoreductase 0.0008 0.0001 0.0004
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0591 0.2176
Loa Loa (eye worm) hypothetical protein 0.0251 1 1
Echinococcus granulosus cytochrome b5 reductase 4 0.0008 0.0001 0.0001
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0536 0.1975
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0591 0.1801
Giardia lamblia Kinase, CMGC CLK 0.006 0.2116 0.8942
Brugia malayi hypothetical protein 0.012 0.4606 1
Entamoeba histolytica protein kinase domain containing protein 0.0088 0.328 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0536 0.6421
Leishmania major cytochrome-b5 reductase, putative 0.0008 0.0001 0.0003
Brugia malayi Protein kinase domain containing protein 0.006 0.2116 0.4595
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0008 0.0001 0.0003
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0835 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0591 0.1801
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0591 0.1801
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0835 1
Leishmania major NADH-cytochrome b5 reductase, putative 0.0008 0.0001 0.0003
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0074 0.2715 0.2715
Entamoeba histolytica protein kinase, putative 0.0088 0.328 1
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0074 0.2715 0.8276
Echinococcus granulosus cytochrome b5 reductase 4 0.0008 0.0001 0.0001
Schistosoma mansoni NADH-cytochrome B5 reductase 0.0008 0.0001 0.0001
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.448 0.448
Echinococcus multilocularis dual specificity 0.0088 0.328 0.328
Loa Loa (eye worm) hypothetical protein 0.0021 0.0536 0.0536
Leishmania major cytochrome P450 reductase, putative 0.0066 0.2367 0.7215
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0835 0.3076
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0591 0.2176
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0074 0.2715 0.2715
Toxoplasma gondii flavodoxin domain-containing protein 0.0037 0.1172 0.5538
Plasmodium vivax flavodoxin domain containing protein 0.0066 0.2367 0.8718
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0008 0.0001 0.0003
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0835 0.2546
Leishmania major p450 reductase, putative 0.0074 0.2715 0.8276
Loa Loa (eye worm) hypothetical protein 0.0021 0.0536 0.0536
Leishmania major NADH-cytochrome b5 reductase, putative 0.0008 0.0001 0.0003
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.006 0.2116 0.6452
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0536 0.1975
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0008 0.0001 0.0003
Loa Loa (eye worm) flavodoxin family protein 0.0028 0.0824 0.0824
Mycobacterium tuberculosis Probable monooxygenase 0.0008 0.0001 0.0011
Schistosoma mansoni cytochrome P450 reductase 0.0074 0.2715 0.2715
Brugia malayi flavodoxin family protein 0.0028 0.0824 0.1789
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0591 0.7165
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0488 0.5844
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0591 0.0591
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.006 0.2116 0.6452
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0591 0.2176
Mycobacterium tuberculosis Possible oxygenase 0.0008 0.0001 0.0011
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0835 0.2546
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0008 0.0001 0.0003
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0835 0.2546
Trypanosoma cruzi cytochrome-b5 reductase, putative 0.0008 0.0001 0.0003
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0008 0.0001 0.0003
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.006 0.2116 0.6452
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0008 0.0001 0.0003
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0028 0.0824 0.3036
Plasmodium falciparum NADH-cytochrome b5 reductase, putative 0.0008 0.0001 0.0004
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0028 0.0824 0.2512
Giardia lamblia Hypothetical protein 0.0066 0.2367 1
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0008 0.0001 0.0003
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0835 0.3076
Chlamydia trachomatis sulfite reductase 0.0046 0.1543 1
Echinococcus granulosus dual specificity 0.0088 0.328 0.328
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0251 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0835 0.3076
Brugia malayi FAD binding domain containing protein 0.0074 0.2715 0.5893
Toxoplasma gondii exonuclease III APE 0.0023 0.0591 0.2791
Leishmania major nitrate reductase, putative 0.0008 0.0001 0.0003
Leishmania major protein kinase, putative 0.006 0.2116 0.6452
Brugia malayi Cytochrome b5-like Heme/Steroid binding domain containing protein 0.0008 0.0001 0.0002
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0008 0.0001 0.0003
Leishmania major NADH-dependent fumarate reductase, putative 0.0008 0.0001 0.0003
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0074 0.2715 1
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0074 0.2715 0.8276
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0835 0.3076
Schistosoma mansoni diflavin oxidoreductase 0.0037 0.1172 0.1172
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0835 0.1813
Loa Loa (eye worm) hypothetical protein 0.012 0.4606 0.4606
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0835 0.3076
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0835 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0591 0.2176
Echinococcus granulosus NADH cytochrome b5 reductase 3 0.0008 0.0001 0.0001
Trichomonas vaginalis CMGC family protein kinase 0.006 0.2116 0.7796
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0028 0.0824 0.2512
Schistosoma mansoni cytochrome B5 0.0008 0.0001 0.0001
Echinococcus multilocularis 0.0059 0.2079 0.2079
Brugia malayi flavodoxin family protein 0.0074 0.2715 0.5893
Trypanosoma cruzi NADH-dependent fumarate reductase, putative 0.0008 0.0001 0.0003
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0591 0.5
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0008 0.0001 0.0003
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0088 0.328 1
Schistosoma mansoni ap endonuclease 0.0023 0.0591 0.0591
Loa Loa (eye worm) CMGC/CLK protein kinase 0.006 0.2116 0.2116
Mycobacterium ulcerans flavodoxin reductase Hmp 0.0008 0.0001 0.0004
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0088 0.328 1
Trypanosoma brucei NADH-cytochrome b5 reductase, putative 0.0008 0.0001 0.0003
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0835 0.2546
Toxoplasma gondii NADH-cytochrome b5 reductase 1, putative 0.0008 0.0001 0.0004
Brugia malayi Protein kinase domain containing protein 0.0088 0.328 0.7121
Trypanosoma brucei NADH-dependent fumarate reductase, putative 0.0008 0.0001 0.0003
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0251 1 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0591 0.2493
Trypanosoma cruzi p450 reductase, putative 0.0074 0.2715 0.8276
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0074 0.2715 0.8276
Trypanosoma cruzi NADH-cytochrome b5 reductase, putative 0.0008 0.0001 0.0003
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0074 0.2715 1
Trypanosoma cruzi oxidoreductase-protein, putative 0.0008 0.0001 0.0003
Schistosoma mansoni serine/threonine protein kinase 0.006 0.2116 0.2116
Leishmania major reductase, putative 0.0008 0.0001 0.0003
Trypanosoma brucei NADH-dependent fumarate reductase 0.0008 0.0001 0.0003
Treponema pallidum flavodoxin 0.0028 0.0824 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0591 0.1801
Loa Loa (eye worm) hypothetical protein 0.0087 0.3243 0.3243
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0088 0.328 1
Echinococcus multilocularis methionine synthase reductase 0.0046 0.1543 0.1543
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.006 0.2116 0.6452
Entamoeba histolytica type A flavoprotein, putative 0.0028 0.0824 0.2512
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0046 0.1543 0.1543
Toxoplasma gondii ferredoxin NADP+ oxidoreductase FNR 0.0008 0.0001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0029 0.0835 0.0835
Mycobacterium ulcerans oxidoreductase 0.0008 0.0001 0.0004
Schistosoma mansoni ap endonuclease 0.0023 0.0591 0.0591
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0074 0.2715 0.2715
Entamoeba histolytica protein kinase, putative 0.0088 0.328 1
Plasmodium falciparum nitric oxide synthase, putative 0.0074 0.2715 1
Plasmodium vivax oxidoreductase NAD-binding domain containing protein 0.0008 0.0001 0.0004
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0028 0.0824 0.3036
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0074 0.2715 0.8276
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0074 0.2715 0.2715
Plasmodium vivax serine/threonine kinase-1, putative 0.006 0.2116 0.7796
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0066 0.2367 0.8718
Plasmodium vivax ferredoxin--NADP reductase, putative 0.0008 0.0001 0.0004
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0824 0.3036
Loa Loa (eye worm) hypothetical protein 0.0021 0.0536 0.0536
Entamoeba histolytica type A flavoprotein, putative 0.0028 0.0824 0.2512
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0835 0.2546
Schistosoma mansoni NADPH flavin oxidoreductase 0.0037 0.1195 0.1195
Toxoplasma gondii flavodoxin domain-containing protein 0.0037 0.1172 0.5538
Trypanosoma brucei nitrate reductase, putative 0.0008 0.0001 0.0003
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0536 0.347
Entamoeba histolytica type A flavoprotein, putative 0.0028 0.0824 0.2512
Giardia lamblia Nitric oxide synthase, inducible 0.0066 0.2367 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0591 0.1801
Trypanosoma cruzi nitrate reductase, putative 0.0008 0.0001 0.0003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0488 0.5844

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8492 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 26.6795 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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