Detailed information for compound 1319181

Basic information

Technical information
  • TDR Targets ID: 1319181
  • Name: 3-[(5E)-5-[(4-methoxyphenyl)methylidene]-2,4- dioxo-1,3-thiazolidin-3-yl]-N-[4-(1,3-thiazol -2-ylsulfamoyl)phenyl]propanamide
  • MW: 544.623 | Formula: C23H20N4O6S3
  • H donors: 2 H acceptors: 6 LogP: 3.04 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)/C=C\1/SC(=O)N(C1=O)CCC(=O)Nc1ccc(cc1)S(=O)(=O)Nc1nccs1
  • InChi: 1S/C23H20N4O6S3/c1-33-17-6-2-15(3-7-17)14-19-21(29)27(23(30)35-19)12-10-20(28)25-16-4-8-18(9-5-16)36(31,32)26-22-24-11-13-34-22/h2-9,11,13-14H,10,12H2,1H3,(H,24,26)(H,25,28)/b19-14+
  • InChiKey: GOGUNBUEDXIKLB-XMHGGMMESA-N  


Substructure search Similarity search

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Synonyms

  • 3-[(5E)-5-[(4-methoxyphenyl)methylene]-2,4-dioxo-thiazolidin-3-yl]-N-[4-(thiazol-2-ylsulfamoyl)phenyl]propanamide
  • 3-[(5E)-5-[(4-methoxyphenyl)methylene]-2,4-dioxo-3-thiazolidinyl]-N-[4-(2-thiazolylsulfamoyl)phenyl]propanamide
  • 3-[(5E)-2,4-diketo-5-(4-methoxybenzylidene)thiazolidin-3-yl]-N-[4-(thiazol-2-ylsulfamoyl)phenyl]propionamide
  • 6049-83-8
  • BIM-0003947.P001
  • 3-[5-(4-methoxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]-N-{4-[(1,3-thiazol-2-ylamino)sulfonyl]phenyl}propanamide
  • MLS000571950
  • SMR000193968

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens myeloid cell leukemia 1 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0029 0.0214 0.1245
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0069 0.0629 0.6894
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0379 0.3725
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0444 0.0517
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.003 0.0024
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0379 0.044
Onchocerca volvulus 0.0018 0.0105 0.0595
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0116 0.1216
Schistosoma mansoni DNA polymerase IV / kappa 0.0019 0.0116 0.013
Chlamydia trachomatis phosphoglycerate kinase 0.0096 0.091 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0134 0.1295 0.1519
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0173 0.0483
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0061 0.0552 0.0644
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0379 0.044
Trypanosoma cruzi DNA polymerase kappa, putative 0.0092 0.0862 0.9469
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0433 0.4721
Loa Loa (eye worm) hypothetical protein 0.0025 0.0173 0.1
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0096 0.091 0.1364
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.01 0.0949 0.0944
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0433 0.4721
Brugia malayi hypothetical protein 0.0016 0.0083 0.0463
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0596 0.6524
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1143 0.1138
Schistosoma mansoni hypothetical protein 0.0011 0.0033 0.0032
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0134 0.1295 0.1291
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.1187 0.7063
Loa Loa (eye worm) hypothetical protein 0.0018 0.0105 0.0596
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0049 0.0426 0.0495
Trypanosoma brucei unspecified product 0.0042 0.0356 0.3872
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0425 0.464
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0173 0.0483
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0583 0.345
Echinococcus granulosus geminin 0.0369 0.372 0.4374
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0096 0.091 0.5
Trypanosoma brucei phosphoglycerate kinase, putative 0.0035 0.0283 0.3065
Schistosoma mansoni cpg binding protein 0.0035 0.0276 0.0319
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0583 0.068
Entamoeba histolytica phosphoglycerate kinase, putative 0.0096 0.091 0.1357
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0931 0.109
Echinococcus granulosus CTD small phosphatase protein like 0.0014 0.0064 0.0068
Mycobacterium ulcerans hypothetical protein 0.0029 0.0214 0.0602
Loa Loa (eye worm) hypothetical protein 0.0062 0.0563 0.333
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.0001
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0014 0.0064 0.0095
Loa Loa (eye worm) hypothetical protein 0.0021 0.0139 0.08
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.0116 0.1216
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0379 0.044
Treponema pallidum hypothetical protein 0.0345 0.3467 1
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0014 0.0064 0.0167
Schistosoma mansoni cpg binding protein 0.0037 0.0296 0.0343
Loa Loa (eye worm) hypothetical protein 0.0049 0.0425 0.2509
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0139 0.0386
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0127 0.0352
Plasmodium falciparum DNA repair protein REV1, putative 0.0019 0.0116 0.0318
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0379 0.044
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0127 0.0352
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0583 0.068
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0345 0.3467 1
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0035 0.0283 0.3065
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0379 0.0568
Schistosoma mansoni hypothetical protein 0.01 0.0949 0.111
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0014 0.0064 0.0641
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0014 0.0064 0.0095
Echinococcus granulosus dna polymerase eta 0.009 0.0849 0.0993
Schistosoma mansoni phosphoglycerate kinase 0.0096 0.091 0.1065
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0096 0.091 0.2613
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0035 0.0283 0.3065
Loa Loa (eye worm) hypothetical protein 0.0008 0.0006 0.0001
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0214 0.0602
Loa Loa (eye worm) hypothetical protein 0.0029 0.0214 0.1245
Loa Loa (eye worm) hypothetical protein 0.0029 0.0214 0.1245
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0134 0.1295 0.1519
Giardia lamblia DNA damage repair protein 0.0019 0.0116 0.0615
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.8498 1
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0116 0.1216
Brugia malayi MH2 domain containing protein 0.0123 0.1187 0.7063
Echinococcus multilocularis expressed protein 0.0049 0.0426 0.0421
Mycobacterium tuberculosis Conserved hypothetical protein 0.0061 0.0552 0.1579
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0214 0.2303
Entamoeba histolytica deoxycytidyl transferase, putative 0.0061 0.0552 0.082
Schistosoma mansoni apoptosis regulator bax 0.01 0.0949 0.111
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0116 0.1216
Echinococcus multilocularis protein patched 0.0051 0.0444 0.0439
Onchocerca volvulus 0.0018 0.0105 0.0595
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0096 0.091 1
Brugia malayi ImpB/MucB/SamB family protein 0.009 0.0849 0.5041
Brugia malayi CXXC zinc finger family protein 0.0035 0.0276 0.1618
Schistosoma mansoni hypothetical protein 0.01 0.0949 0.111
Echinococcus multilocularis phosphoglycerate kinase 1 0.0096 0.091 0.0905
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0014 0.0064 0.0167
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0027 0.0192 0.2066
Trypanosoma brucei unspecified product 0.0042 0.0356 0.3872
Trypanosoma brucei DNA polymerase kappa, putative 0.0092 0.0862 0.9469
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0134 0.1295 0.7711
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0214 0.0602
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0092 0.0862 0.1292
Brugia malayi hypothetical protein 0.0171 0.1678 1
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0006 0.0001
Mycobacterium ulcerans phosphoglycerate kinase 0.0096 0.091 0.2613
Brugia malayi hypothetical protein 0.0019 0.0119 0.068
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0173 0.1848
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0444 0.0439
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1143 0.68
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0214 0.1245
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0014 0.0064 0.0068
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.0931 0.5531
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0379 0.0374
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0033 0.0032
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0035 0.0283 0.3065
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0061 0.0552 0.0547
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0096 0.091 1
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0014 0.0064 0.0095
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.0116 0.1216
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0049 0.0426 0.2515
Plasmodium vivax DNA repair protein REV1, putative 0.0019 0.0116 0.0318
Schistosoma mansoni hypothetical protein 0.0049 0.0425 0.0494
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0139 0.0386
Leishmania major DNA polymerase eta, putative 0.0048 0.0412 0.4496
Loa Loa (eye worm) oxidoreductase 0.0008 0.0006 0.0001
Trichomonas vaginalis DNA polymerase eta, putative 0.0092 0.0862 0.1292
Echinococcus granulosus cpg binding protein 0.0037 0.0296 0.0343
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0064 0.0641
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.01 0.0949 0.111
Trypanosoma brucei DNA polymerase IV, putative 0.0092 0.0862 0.9469
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0214 0.0602
Leishmania major phosphoglycerate kinase C, glycosomal 0.0096 0.091 1
Brugia malayi polk-prov protein 0.0049 0.0425 0.2509
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0008 0.0002
Echinococcus granulosus dna polymerase kappa 0.0092 0.0862 0.1008
Loa Loa (eye worm) hypothetical protein 0.0021 0.0139 0.08
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0379 0.2232
Loa Loa (eye worm) hypothetical protein 0.0051 0.0444 0.2623
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0009 0.0009 0.0005
Schistosoma mansoni hypothetical protein 0.0494 0.5004 0.5886
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0127 0.0352
Brugia malayi Muscle positioning protein 4 0.0018 0.0105 0.0596
Onchocerca volvulus 0.0018 0.0105 0.0595
Trypanosoma brucei DNA polymerase eta, putative 0.009 0.0849 0.9325
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0931 0.109
Brugia malayi Protein kinase domain containing protein 0.0019 0.0119 0.068
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0096 0.091 1
Mycobacterium ulcerans DNA polymerase IV 0.0092 0.0862 0.2474
Loa Loa (eye worm) hypothetical protein 0.0096 0.091 0.5406
Schistosoma mansoni hypothetical protein 0.0019 0.0119 0.0134
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0214 0.0602
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0049 0.0426 0.4651
Trypanosoma brucei DNA polymerase kappa, putative 0.0092 0.0862 0.9469
Schistosoma mansoni DNA polymerase eta 0.009 0.0849 0.0993
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0096 0.091 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0214 0.2303
Trichomonas vaginalis dullard protein, putative 0.0014 0.0064 0.0095
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0008 0.0003
Echinococcus multilocularis protein dispatched 1 0.0058 0.0519 0.0513
Brugia malayi hypothetical protein 0.0025 0.0173 0.1
Echinococcus multilocularis tumor protein p63 0.0408 0.412 0.4116
Leishmania major hypothetical protein, conserved 0.0014 0.0064 0.0641
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0006 0.0001
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0345 0.3467 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0214 0.0602
Brugia malayi Phosphoglycerate kinase 0.0096 0.091 0.5406
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0014 0.0064 0.0087
Echinococcus granulosus phosphoglycerate kinase 1 0.0096 0.091 0.1065
Plasmodium falciparum phosphoglycerate kinase 0.0096 0.091 0.2613
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0173 0.0483
Trichomonas vaginalis dullard protein, putative 0.0014 0.0064 0.0095
Loa Loa (eye worm) hypothetical protein 0.0018 0.0105 0.0596
Onchocerca volvulus 0.0029 0.0214 0.1245
Echinococcus multilocularis 0.0014 0.0064 0.0058
Echinococcus multilocularis dna polymerase kappa 0.0092 0.0862 0.0857
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0035 0.0283 0.3065
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.0931 0.5531
Trypanosoma brucei chrX additional, unordered contigs 0.0019 0.0116 0.1216
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0019 0.0116 0.1216
Loa Loa (eye worm) DOMON domain-containing protein 0.0018 0.0105 0.0596
Onchocerca volvulus 0.0171 0.1678 1
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0656 0.6668 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0214 0.1245
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0035 0.0283 0.3065
Brugia malayi TAR-binding protein 0.0064 0.0583 0.345
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0379 0.4127
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0214 0.0602
Trypanosoma brucei DNA polymerase IV, putative 0.0084 0.0785 0.8619
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0014 0.0064 0.0347
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0069 0.0629 0.1801
Trypanosoma cruzi DNA polymerase kappa, putative 0.0092 0.0862 0.9469
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.01 0.0949 0.5637
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0444 0.0517
Echinococcus granulosus dnaJ subfamily B 0.0494 0.5004 0.5886
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0028 0.0135
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0035 0.0283 0.3065
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.01 0.0949 0.111
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0345 0.3467 1
Echinococcus granulosus MAM 0.0019 0.0119 0.0134
Trypanosoma brucei DNA polymerase kappa, putative 0.0092 0.0862 0.9469
Toxoplasma gondii TIM10 family protein, putative 0.0049 0.0426 0.4651
Onchocerca volvulus 0.0019 0.0119 0.0679
Loa Loa (eye worm) hypothetical protein 0.0014 0.0062 0.0337
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0931 0.0926
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.1187 0.7063
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0534 0.0622
Trypanosoma brucei DNA polymerase kappa, putative 0.0092 0.0862 0.9469
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0214 0.0602
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.01 0.0949 0.0944
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0008 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0214 0.1245
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0583 0.068
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0379 0.4127
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0061 0.0552 0.0644
Loa Loa (eye worm) RNA binding protein 0.0064 0.0583 0.345
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.0116 0.1216
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0014 0.0064 0.0058
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0379 0.0374
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0096 0.091 0.1364
Echinococcus granulosus microtubule associated protein 2 0.0833 0.8498 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.1143 0.68
Trypanosoma brucei DNA polymerase kappa, putative 0.0092 0.0862 0.9469
Trypanosoma brucei phosphoglycerate kinase 0.0096 0.091 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0173 0.1848
Loa Loa (eye worm) apoptosis regulator protein 0.01 0.0949 0.5637
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0173 0.1848
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0214 0.0602
Leishmania major DNA polymerase kappa, putative 0.0069 0.0629 0.6894
Giardia lamblia DINP protein human, muc B family 0.0069 0.0629 0.6682
Loa Loa (eye worm) hypothetical protein 0.0021 0.0139 0.08
Trypanosoma cruzi DNA polymerase kappa, putative 0.0092 0.0862 0.9469
Trypanosoma brucei DNA polymerase IV, putative 0.0092 0.0862 0.9469
Entamoeba histolytica dual specificity protein phosphatase, putative 0.0656 0.6668 1
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0096 0.091 0.2613
Trypanosoma brucei DNA polymerase kappa, putative 0.0092 0.0862 0.9469
Trypanosoma brucei DNA polymerase kappa, putative 0.0092 0.0862 0.9469
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0014 0.0064 0.0167
Mycobacterium ulcerans DNA polymerase IV 0.0092 0.0862 0.2474
Schistosoma mansoni hypothetical protein 0.0018 0.0105 0.0117
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0173 0.1848
Echinococcus multilocularis geminin 0.0369 0.372 0.3716
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0006 0.0008
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0061 0.0552 0.3268
Schistosoma mansoni hypothetical protein 0.0014 0.0062 0.0066
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0931 0.109
Plasmodium vivax phosphoglycerate kinase, putative 0.0096 0.091 0.2613
Leishmania major DNA polymerase kappa, putative 0.0019 0.0116 0.1216
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0276 0.1618
Schistosoma mansoni hypothetical protein 0.0369 0.372 0.4374
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1668 0.1664
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0008 0.0003
Echinococcus granulosus tar DNA binding protein 0.0064 0.0583 0.068
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0379 0.0374
Trypanosoma cruzi DNA polymerase kappa, putative 0.0092 0.0862 0.9469
Schistosoma mansoni phosphoglycerate kinase 0.0096 0.091 0.1065
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0134 0.1295 0.1291
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0006 0.0008
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0214 0.0312
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1668 0.1958
Onchocerca volvulus 0.006 0.0534 0.3158
Schistosoma mansoni cpg binding protein 0.0037 0.0296 0.0343
Onchocerca volvulus 0.0018 0.0105 0.0595
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0134 0.1295 0.1519
Trichomonas vaginalis dullard protein, putative 0.0014 0.0064 0.0095
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0006 0.0001
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0345 0.3467 1
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0014 0.0064 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0092 0.0862 0.9469
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0008 0.0003
Echinococcus multilocularis cpg binding protein 0.0037 0.0296 0.0291
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0014 0.0064 0.0068
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0006 0.0001
Trypanosoma brucei phosphoglycerate kinase 0.0096 0.091 1
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0433 0.4721
Echinococcus multilocularis dna polymerase eta 0.009 0.0849 0.0844
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0014 0.0064 0.0641
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0214 0.0312
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0006 0.0001
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0014 0.0064 0.0095
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0049 0.0426 0.1215
Brugia malayi SEA domain containing protein 0.0018 0.0105 0.0596
Leishmania major phosphoglycerate kinase B, cytosolic 0.0096 0.091 1
Giardia lamblia Phosphoglycerate kinase 0.0096 0.091 1
Leishmania major hypothetical protein, conserved 0.0025 0.0173 0.1848
Trypanosoma brucei unspecified product 0.0084 0.0785 0.8619
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0006 0.0001
Brugia malayi CHE-14 protein 0.0051 0.0444 0.2623
Loa Loa (eye worm) hypothetical protein 0.01 0.0949 0.5637
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1143 0.1707
Leishmania major DNA polymerase eta, putative 0.009 0.0849 0.9325
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0214 0.0602
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0583 0.0578
Loa Loa (eye worm) hypothetical protein 0.0014 0.0064 0.0347
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0214 0.0602
Loa Loa (eye worm) TK/ALK protein kinase 0.0019 0.0119 0.068
Schistosoma mansoni hypothetical protein 0.0049 0.0425 0.0494
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.0116 0.1216
Loa Loa (eye worm) hypothetical protein 0.009 0.0849 0.5041
Loa Loa (eye worm) histone methyltransferase 0.0011 0.003 0.0144
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0116 0.1216
Onchocerca volvulus 0.0018 0.0105 0.0595
Loa Loa (eye worm) hypothetical protein 0.0171 0.1678 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0214 0.0312
Loa Loa (eye worm) hypothetical protein 0.0021 0.0139 0.08
Loa Loa (eye worm) hypothetical protein 0.0021 0.0139 0.08
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0379 0.4127
Trypanosoma brucei DNA polymerase kappa, putative 0.0049 0.0425 0.464
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0048 0.0412 0.4496
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0379 0.044
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0006 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0379 0.0568
Loa Loa (eye worm) hypothetical protein 0.0045 0.0379 0.2232
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.0931 0.0926
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0583 0.068
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0049 0.0426 0.2515
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.0931 0.109
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.003 0.0028
Onchocerca volvulus 0.0019 0.0119 0.0679
Schistosoma mansoni hypothetical protein 0.0019 0.0119 0.0134
Onchocerca volvulus 0.0035 0.0276 0.1617
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.068
Brugia malayi RNA binding protein 0.0064 0.0583 0.345
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1162 0.1362
Schistosoma mansoni hypothetical protein 0.01 0.0949 0.111
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0006 0.0001
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0379 0.0568
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0583 0.345
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.01 0.0949 0.111
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0049 0.0426 0.1215
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0379 0.4127
Schistosoma mansoni terminal deoxycytidyl transferase 0.0061 0.0552 0.0644
Schistosoma mansoni patched 1 0.0051 0.0444 0.0517
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0676 0.079
Echinococcus granulosus expressed conserved protein 0.0112 0.1069 0.1252
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.068
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0345 0.3467 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0092 0.0862 0.9469
Echinococcus multilocularis expressed conserved protein 0.0112 0.1069 0.1064
Trypanosoma cruzi DNA polymerase eta, putative 0.009 0.0849 0.9325
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0379 0.056
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0033 0.0027
Leishmania major DNA damage repair protein, putative 0.0019 0.0116 0.1216
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.5004 0.5001
Loa Loa (eye worm) hypothetical protein 0.006 0.0534 0.3159
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0583 0.345
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0583 0.068
Trypanosoma brucei phosphoglycerate kinase 0.0035 0.0283 0.3065
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0444 0.0666
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.0931 0.109
Brugia malayi ImpB/MucB/SamB family protein 0.0061 0.0552 0.3268
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0444 0.2623
Echinococcus multilocularis MAM 0.0019 0.0119 0.0114
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.8498 0.8497
Echinococcus granulosus expressed protein 0.0049 0.0426 0.0495
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0134 0.1295 0.7711
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0139 0.0386
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0127 0.0352
Echinococcus granulosus tumor protein p63 0.0408 0.412 0.4845
Schistosoma mansoni hypothetical protein 0.0049 0.0425 0.0494
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0139 0.0386
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0629 0.6894
Trypanosoma cruzi DNA polymerase eta, putative 0.0048 0.0412 0.4496
Mycobacterium ulcerans hypothetical protein 0.0019 0.0116 0.0318
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0214 0.0602
Schistosoma mansoni hypothetical protein 0.0369 0.372 0.4374
Brugia malayi Phosphoglycerate kinase 0.0035 0.0283 0.1658
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1143 0.1339
Schistosoma mansoni hypothetical protein 0.0049 0.0425 0.0494
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0214 0.2303
Loa Loa (eye worm) hypothetical protein 0.0019 0.0119 0.068

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 3.763939636 um PUBCHEM_BIOASSAY: Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors. (Class of assay: confirmatory) [Related pubchem assays: 1022 (Primary screen preceding this dose-response assay.)] ChEMBL. No reference
Potency (functional) 2.3934 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 3.2944 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 21.1923 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 42.5615 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 63.0957 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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