TDR Targets

Basic information

Technical information

TDR Targets ID: 131969
Name: (4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-thi ophen-2-ylmethanone
MW: 301.364 | Formula: C15H15N3O2S
H donors: 1 H acceptors: 3 LogP: 2.65 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCCCOc1c(c[nH]c2c1cnn2)C(=O)c1cccs1
InChi: 1S/C15H15N3O2S/c1-2-3-6-20-14-10(13(19)12-5-4-7-21-12)8-16-15-11(14)9-17-18-15/h4-5,7-9H,2-3,6H2,1H3,(H,16,17,18)
InChiKey: OJKVXMJPYGVMGB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-(2-thienyl)methanone
(4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-thiophen-2-yl-methanone
(4-butoxy-1H-pyrazolo[4,3-e]pyridin-5-yl)-thiophen-2-ylmethanone
(4-butoxy-1H-pyrazolo[4,3-e]pyridin-5-yl)-(2-thienyl)methanone
(4-butoxy-1H-pyrazolo[4,3-e]pyridin-5-yl)-thiophen-2-yl-methanone
SQ-67563 Analog 10f

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cyclin B2	Starlite/ChEMBL	References
Homo sapiens	cyclin B3	Starlite/ChEMBL	References
Homo sapiens	cyclin E2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	cyclin B	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania mexicana	cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma brucei	mitotic cyclin 6	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania braziliensis	CYC2-like cyclin, putative,cyclin 6, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclin B, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania donovani	cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma cruzi	CYC2-like cyclin, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclins, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma cruzi	cyclin 6, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania braziliensis	cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania major	cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma brucei gambiense	cyclin 6,mitotic cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania donovani	CYC2-like cyclin, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma cruzi	cyclin, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Schistosoma mansoni	cyclin B	Get druggable targets OG5_126649	All targets in OG5_126649
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126649	All targets in OG5_126649
Entamoeba histolytica	cyclin, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Schistosoma japonicum	IPR002155,Thiolase,domain-containing	Get druggable targets OG5_134175	All targets in OG5_134175
Trichomonas vaginalis	cyclin B, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Cryptosporidium parvum	cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Schistosoma japonicum	ko:K05868 cyclin B, putative	Get druggable targets OG5_134175	All targets in OG5_134175
Loa Loa (eye worm)	cyclin domain-containing protein	Get druggable targets OG5_134175	All targets in OG5_134175
Trichomonas vaginalis	cyclin B, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma congolense	Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Candida albicans	hypothetical protein	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclin A, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Onchocerca volvulus		Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma congolense	mitotic cyclin 6	Get druggable targets OG5_126649	All targets in OG5_126649
Giardia lamblia	G2/mitotic-specific cyclin B	Get druggable targets OG5_126649	All targets in OG5_126649
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126649	All targets in OG5_126649
Schistosoma mansoni	cyclin B3	Get druggable targets OG5_134175	All targets in OG5_134175
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Schistosoma japonicum	ko:K05868 cyclin B, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Echinococcus multilocularis	G2:mitotic specific cyclin B3	Get druggable targets OG5_134175	All targets in OG5_134175
Brugia malayi	Cyclin, N-terminal domain containing protein	Get druggable targets OG5_134175	All targets in OG5_134175
Leishmania infantum	cyclin	Get druggable targets OG5_126649	All targets in OG5_126649
Leishmania mexicana	CYC2-like cyclin, putative,cyclin 6, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Candida albicans	likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction	Get druggable targets OG5_126649	All targets in OG5_126649
Brugia malayi	Cyclin, N-terminal domain containing protein	Get druggable targets OG5_126649	All targets in OG5_126649
Candida albicans	likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction	Get druggable targets OG5_126649	All targets in OG5_126649
Cryptosporidium hominis	mitotic cyclin-CYC2	Get druggable targets OG5_126649	All targets in OG5_126649
Brugia malayi	Cyclin, N-terminal domain containing protein	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclins, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Candida albicans	likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclins, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclins, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclin B, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Trichomonas vaginalis	cyclins, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Echinococcus multilocularis	cyclin B	Get druggable targets OG5_126649	All targets in OG5_126649
Trypanosoma cruzi	cyclin, putative	Get druggable targets OG5_126649	All targets in OG5_126649
Echinococcus granulosus	G2:mitotic specific cyclin B3	Get druggable targets OG5_134175	All targets in OG5_134175
Leishmania infantum	CYC2-like cyclin, putative,cyclin 6, putative	Get druggable targets OG5_126649	All targets in OG5_126649

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Hypothetical protein	0.0064	0.1526	0.6702
Leishmania major	GTP-binding protein, putative	0.0021	0.0439	0.1928
Brugia malayi	Latrophilin receptor protein 2	0.0005	0.0038	0.0077
Plasmodium falciparum	importin beta, putative	0.0028	0.0627	0.4025
Schistosoma mansoni	synaptojanin	0.0004	0.0021	0.0021
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0076	0.0335
Trichomonas vaginalis	cyclin B, putative	0.0016	0.0305	0.1337
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.1444	0.1444
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0492	0.2162
Entamoeba histolytica	sphingomyelinase C precursor, putative	0.0004	0.0021	0.0092
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0021	0.0043
Entamoeba histolytica	cyclin, domain containing protein	0.0016	0.0305	0.1337
Entamoeba histolytica	inositol polyphosphate 5-phosphatase, putative	0.0004	0.0021	0.0092
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0021	0.0043
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0141	0.0141
Schistosoma mansoni	Smad4	0.0004	0.0017	0.0017
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0092	0.0092
Echinococcus granulosus	mothers against decapentaplegic 5	0.0009	0.0141	0.0141
Entamoeba histolytica	cyclin family protein	0.0064	0.1526	0.6702
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0076	0.0335
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0016	0.0305	0.0305
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0076	0.0335
Brugia malayi	MH1 domain containing protein	0.0009	0.0141	0.0289
Giardia lamblia	Hypothetical protein	0.0016	0.0305	0.1337
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0015	0.0301	0.0401
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0021	0.0028
Schistosoma mansoni	smad	0.0004	0.0017	0.0017
Schistosoma mansoni	cyclin G2	0.0016	0.0305	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0305	0.0406
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0004	0.0021	0.0144
Trichomonas vaginalis	sphingomyelinase C 2 precursor, putative	0.0004	0.0021	0.0092
Trypanosoma brucei	mitotic cyclin 6	0.0094	0.2277	1
Toxoplasma gondii	hypothetical protein	0.0016	0.0305	0.2109
Brugia malayi	MH1 domain containing protein	0.0005	0.0041	0.0083
Onchocerca volvulus		0.0004	0.0021	0.0092
Leishmania major	hypothetical protein, conserved	0.0005	0.005	0.0221
Toxoplasma gondii	HEAT repeat-containing protein	0.0005	0.005	0.0349
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0004	0.0021	0.0092
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0004	0.0021	0.0092
Echinococcus granulosus	snurportin 1	0.0303	0.7505	0.7505
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0627	1
Plasmodium falciparum	transportin	0.0005	0.005	0.0196
Entamoeba histolytica	HEAT repeat domain containing protein	0.0005	0.005	0.0221
Entamoeba histolytica	hypothetical protein	0.0016	0.0305	0.1337
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0021	0.0043
Echinococcus multilocularis	mothers against decapentaplegic 2	0.0004	0.0017	0.0017
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0492	0.2162
Trichomonas vaginalis	cyclins, putative	0.0064	0.1526	0.6702
Echinococcus granulosus	cyclins	0.0064	0.1526	0.1526
Loa Loa (eye worm)	Smad1	0.0009	0.0141	0.0188
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0021	0.0436	0.3017
Trypanosoma brucei	cyclin 9	0.0016	0.0305	0.1337
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0094	0.2277	0.4656
Loa Loa (eye worm)	cyclin domain-containing protein	0.0199	0.4891	0.6518
Echinococcus granulosus	leucine rich repeat serine:threonine protein	0.0037	0.0837	0.0837
Leishmania major	endonuclease/exonuclease protein-like protein	0.0004	0.0021	0.0092
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0004	0.0017	0.0017
Giardia lamblia	hypothetical protein	0.0004	0.0021	0.0092
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0016	0.0305	0.0623
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0004	0.0021	0.0144
Schistosoma mansoni	hypothetical protein	0.0011	0.0179	0.0179
Loa Loa (eye worm)	CCR4-NOT transcription complex subunit 6 family protein	0.0004	0.0022	0.0029
Echinococcus granulosus	Cyclin L1	0.0016	0.0305	0.0305
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0076	0.0335
Leishmania major	hypothetical protein, conserved	0.0004	0.0021	0.0092
Leishmania major	RNA-editing complex protein MP100, putative	0.0004	0.0021	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0094	0.2277	0.3035
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0005	0.0038	0.0077
Trypanosoma cruzi	mitochondrial protein 99, putative	0.0004	0.0021	0.0092
Loa Loa (eye worm)	nuclear factor I	0.0005	0.0041	0.0054
Trypanosoma brucei	DNA-(apurinic or apyrimidinic site) lyase, putative	0.0004	0.0021	0.0092
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0439	0.0898
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0436	0.1913
Trypanosoma brucei	RNA editing exonuclease 2	0.0004	0.0021	0.0092
Mycobacterium tuberculosis	Probable exported protein	0.0004	0.0021	0.0144
Echinococcus multilocularis	cyclin B3 1	0.0064	0.1526	0.1526
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0305	0.1337
Brugia malayi	Cytochrome P450 family protein	0.0004	0.0011	0.0022
Brugia malayi	kap beta 3 protein	0.0005	0.005	0.0103
Trypanosoma cruzi	Endonuclease/Exonuclease/phosphatase family, putative	0.0004	0.0021	0.0092
Trypanosoma cruzi	Endonuclease/Exonuclease/phosphatase family, putative	0.0004	0.0021	0.0092
Echinococcus multilocularis	leucine rich repeat serine:threonine protein	0.0037	0.0831	0.0831
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0004	0.0021	0.0092
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0436	0.6847
Echinococcus granulosus	cyclin y	0.0016	0.0305	0.0305
Brugia malayi	MH1 domain containing protein	0.0005	0.0041	0.0083
Loa Loa (eye worm)	cyclin C	0.0016	0.0305	0.0406
Echinococcus granulosus	cdk5 and abl1 enzyme substrate 1	0.0016	0.0305	0.0305
Brugia malayi	Smad1	0.0009	0.0141	0.0289
Schistosoma mansoni	smad	0.0009	0.0141	0.0141
Loa Loa (eye worm)	CYL-1 protein	0.0016	0.0305	0.0406
Entamoeba histolytica	cyclin C, putative	0.0016	0.0305	0.1337
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0004	0.0021	0.0028
Brugia malayi	CCR4	0.0004	0.0022	0.0045
Echinococcus multilocularis	cyclin G2	0.0016	0.0305	0.0305
Onchocerca volvulus	Putative neutral sphingomyelinase	0.0004	0.0021	0.0092
Trypanosoma brucei	Endonuclease/Exonuclease/phosphatase family, putative	0.0004	0.0021	0.0092
Trichomonas vaginalis	hypothetical protein	0.0003	0.0002	0.0009
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0005	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0017	0.0022
Echinococcus multilocularis	cyclin G2	0.0016	0.0305	0.0305
Onchocerca volvulus	Mothers against decapentaplegic homolog	0.0004	0.0017	0.0073
Trypanosoma cruzi	cytochrome P450, putative	0.0004	0.0011	0.0048
Trichomonas vaginalis	type IV inositol 5-phosphatase, putative	0.0004	0.0021	0.0092
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0004	0.0021	0.0092
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0004	0.0021	0.0028
Schistosoma mansoni	ran	0.0021	0.0439	0.0439
Schistosoma mansoni	Cyclin fold protein	0.0016	0.0305	0.0305
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.1444	1
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0439	0.304
Echinococcus granulosus	translational activator gcn1	0.0005	0.005	0.005
Loa Loa (eye worm)	transcription factor SMAD2	0.0132	0.3226	0.4299
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0021	0.0436	1
Brugia malayi	MH2 domain containing protein	0.0004	0.0017	0.0034
Echinococcus multilocularis	cyclin k	0.0016	0.0305	0.0305
Plasmodium falciparum	cyclin	0.0064	0.1526	1
Trypanosoma cruzi	Endonuclease/Exonuclease/phosphatase family, putative	0.0004	0.0021	0.0092
Echinococcus multilocularis	cyclin A3 4	0.0016	0.0305	0.0305
Trichomonas vaginalis	cyclin B, putative	0.0064	0.1526	0.6702
Loa Loa (eye worm)	importin-beta domain-containing protein	0.0005	0.005	0.0067
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0135	0.0135
Schistosoma mansoni	cpg binding protein	0.003	0.0664	0.0664
Plasmodium vivax	transportin, putative	0.0005	0.005	0.0487
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0439	0.1928
Toxoplasma gondii	HEAT repeat-containing protein	0.0005	0.005	0.0349
Echinococcus granulosus	cyclin k	0.0016	0.0305	0.0305
Loa Loa (eye worm)	TKL/LRRK protein kinase	0.0037	0.0831	0.1107
Toxoplasma gondii	cyclin 4, putative	0.0016	0.0305	0.2109
Brugia malayi	Protein kinase domain containing protein	0.0037	0.0831	0.1699
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0004	0.0021	0.0021
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0076	0.0335
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0021	0.0043
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0492	0.2162
Mycobacterium leprae	PROBABLE GAMMA-GLUTAMYL PHOSPHATE REDUCTASE PROTEIN PROA (GPR) (GLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE) (GLUTAMYL-GAMMA-SEMIALDE	0.0003	0	0.5
Schistosoma mansoni	ocrl type II inositol 5-phosphatase	0.0004	0.0021	0.0021
Echinococcus granulosus	cyclin y	0.0016	0.0305	0.0305
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0076	0.0335
Trichomonas vaginalis	cyclin B, putative	0.0094	0.2277	1
Leishmania major	inositol/phosphatidylinositol phosphatase, putative	0.0004	0.0021	0.0092
Echinococcus granulosus	Smad4	0.0009	0.0141	0.0141
Onchocerca volvulus	Cyclin L homolog	0.0016	0.0305	0.1337
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0004	0.0021	0.0144
Echinococcus granulosus	cyclin	0.0016	0.0305	0.0305
Toxoplasma gondii	cyclin, N-terminal domain-containing protein	0.0016	0.0305	0.2109
Trypanosoma cruzi	RNA-editing complex protein MP100, putative	0.0004	0.0021	0.0092
Loa Loa (eye worm)	CYP4Cod1	0.0004	0.0011	0.0015
Toxoplasma gondii	exonuclease III APE	0.0021	0.0436	0.3017
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0094	0.2277	1
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0021	0.0043
Trichomonas vaginalis	cyclin B3, putative	0.0016	0.0305	0.1337
Leishmania major	cyclin	0.0094	0.2277	1
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0439	0.1928
Echinococcus multilocularis	smad	0.0009	0.0141	0.0141
Trichomonas vaginalis	cyclin B, putative	0.0016	0.0305	0.1337
Brugia malayi	Cyclin C	0.0016	0.0305	0.0623
Echinococcus multilocularis	snurportin 1	0.0303	0.7505	0.7505
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0005	0.0038	0.0038
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0004	0.0021	0.0092
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0439	0.0439
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0303	0.7505	1
Toxoplasma gondii	cyclin domain protein, cyclin H family protein	0.0016	0.0305	0.2109
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0021	0.0043
Trichomonas vaginalis	ocrl type II inositol 5-phosphatase, putative	0.0004	0.0021	0.0092
Echinococcus multilocularis	GPCR, family 2	0.0005	0.0038	0.0038
Trypanosoma cruzi	mitochondrial protein 99, putative	0.0004	0.0021	0.0092
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0094	0.2277	1
Trypanosoma brucei	inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative	0.0004	0.0021	0.0092
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0624	0.0831
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0021	0.0436	0.1913
Echinococcus multilocularis	cyclin	0.0016	0.0305	0.0305
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0076	0.0335
Trichomonas vaginalis	cyclin B, putative	0.0094	0.2277	1
Echinococcus multilocularis	Smad4	0.0009	0.0141	0.0141
Echinococcus granulosus	cyclins	0.0064	0.1526	0.1526
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0627	0.0627
Trichomonas vaginalis	cyclin A, putative	0.0094	0.2277	1
Echinococcus multilocularis	cyclin b3	0.0064	0.1526	0.1526
Trichomonas vaginalis	cyclins, putative	0.0094	0.2277	1
Giardia lamblia	Hypothetical protein	0.0016	0.0305	0.1337
Trypanosoma brucei	Importin-beta N-terminal domain/HEAT-like repeat, putative	0.0005	0.005	0.0221
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0436	0.2756
Toxoplasma gondii	cyclin dependent kinase binding protein	0.0016	0.0305	0.2109
Giardia lamblia	Cyclin B-like protein	0.0016	0.0305	0.1337
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0021	0.0028
Schistosoma mansoni	synaptojanin	0.0004	0.0021	0.0021
Trichomonas vaginalis	cyclins, putative	0.0016	0.0305	0.1337
Echinococcus multilocularis	synaptojanin 1	0.0004	0.0021	0.0021
Echinococcus granulosus	cyclins	0.0016	0.0305	0.0305
Echinococcus granulosus	importin 5	0.0005	0.005	0.005
Echinococcus multilocularis	deoxyribonuclease 1 2	0.0004	0.0021	0.0021
Leishmania major	mitotic cyclin, putative	0.0016	0.0305	0.1337
Echinococcus multilocularis	cyclins	0.0064	0.1526	0.1526
Entamoeba histolytica	inositol polyphosphate-5-phosphatase, putative	0.0004	0.0021	0.0092
Onchocerca volvulus		0.0094	0.2277	1
Echinococcus multilocularis	cpg binding protein	0.003	0.0664	0.0664
Brugia malayi	latrophilin 2 splice variant baaae	0.0011	0.0179	0.0366
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0004	0.0021	0.0144
Echinococcus multilocularis	importin 5	0.0005	0.005	0.005
Trypanosoma cruzi	cytochrome P450, putative	0.0004	0.0011	0.0048
Trypanosoma brucei	Endonuclease/Exonuclease/phosphatase family, putative	0.0004	0.0021	0.0092
Echinococcus granulosus	CCR4 NOT transcription complex subunit 6	0.0004	0.0021	0.0021
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.1526	0.6702
Schistosoma mansoni	g1/s-specific cyclin C	0.0016	0.0305	0.0305
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0076	0.0335
Loa Loa (eye worm)	cyclin domain-containing protein	0.0016	0.0305	0.0406
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0021	0.0436	1
Trypanosoma cruzi	cyclin, putative	0.0094	0.2277	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0004	0.0011	0.0015
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0076	0.0335
Trichomonas vaginalis	cyclin A, putative	0.0016	0.0305	0.1337
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0004	0.0021	0.0028
Schistosoma mansoni	cript-related	0.0004	0.0021	0.0021
Echinococcus multilocularis	mothers against decapentaplegic 6	0.0004	0.0017	0.0017
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0016	0.0305	0.0623
Trypanosoma brucei	cytochrome P450, putative	0.0004	0.0011	0.0048
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0009	0.0141	0.0141
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0004	0.0021	0.0028
Schistosoma mansoni	cyclin l	0.0016	0.0305	0.0305
Schistosoma mansoni	Smad4	0.0004	0.0017	0.0017
Trypanosoma cruzi	cyclin 6, putative	0.0094	0.2277	1
Echinococcus granulosus	GPCR family 2	0.0005	0.0038	0.0038
Trypanosoma cruzi	Endonuclease/Exonuclease/phosphatase family, putative	0.0004	0.0021	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0627	0.0835
Echinococcus granulosus	cyclin t1	0.0016	0.0305	0.0305
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0436	0.1913
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0004	0.0021	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0305	0.0406
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0005	0.0038	0.005
Echinococcus multilocularis	neutral sphingomyelinase	0.0004	0.0021	0.0021
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0076	0.0335
Giardia lamblia	Inositol 5-phosphatase 4	0.0004	0.0021	0.0092
Treponema pallidum	hypothetical protein	0.0004	0.0021	0.0478
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0004	0.0021	0.0144
Entamoeba histolytica	endonuclease/exonuclease/phosphatase domain containing protein	0.0004	0.0021	0.0092
Echinococcus multilocularis	cdk5 and abl1 enzyme substrate 1	0.0016	0.0305	0.0305
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0016	0.0305	0.0623
Trichomonas vaginalis	cyclin B3, putative	0.0016	0.0305	0.1337
Trichomonas vaginalis	cyclins, putative	0.0094	0.2277	1
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0076	0.0335
Echinococcus multilocularis	cyclins	0.0064	0.1526	0.1526
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0015	0.0301	0.0615
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0436	0.1913
Trypanosoma cruzi	Endonuclease/Exonuclease/phosphatase family, putative	0.0004	0.0021	0.0092
Leishmania major	cyclin 9, putative	0.0016	0.0305	0.1337
Echinococcus granulosus	cyclins	0.0064	0.1526	0.1526
Loa Loa (eye worm)	cytochrome P450 family protein	0.0004	0.0011	0.0015
Trypanosoma brucei	inositol/phosphatidylinositol phosphatase, putative	0.0004	0.0021	0.0092
Onchocerca volvulus	Protein CNPPD1 homolog	0.0016	0.0305	0.1337
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.1444	0.1444
Plasmodium falciparum	cyclin dependent kinase binding protein, putative	0.0016	0.0305	0.1884
Leishmania major	hypothetical protein, conserved	0.0004	0.0021	0.0092
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.1444	0.1444
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0004	0.0021	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0041	0.0054
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0627	0.2752
Schistosoma mansoni	hypothetical protein	0.0005	0.0038	0.0038
Plasmodium vivax	cyclin homologue, putative	0.0016	0.0305	0.4682
Trichomonas vaginalis	Phospholipase C precursor, putative	0.0004	0.0021	0.0092
Entamoeba histolytica	cyclin, putative	0.0094	0.2277	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.0436	0.0436
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0021	0.0043
Trichomonas vaginalis	hypothetical protein	0.0005	0.005	0.0221
Brugia malayi	mothers against decapentaplegic homolog 3	0.0004	0.0017	0.0034
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0004	0.0021	0.0021
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.1444	1
Brugia malayi	Importin beta-1 subunit	0.0028	0.0627	0.1281
Echinococcus granulosus	mothers against decapentaplegic 6	0.0004	0.0017	0.0017
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0092	0.0092
Echinococcus granulosus	mothers against decapentaplegic 2	0.0004	0.0017	0.0017
Schistosoma mansoni	hypothetical protein	0.0303	0.7505	0.7505
Trichomonas vaginalis	cyclin D, putative	0.0064	0.1526	0.6702
Echinococcus multilocularis	transportin 1	0.0005	0.005	0.005
Loa Loa (eye worm)	hypothetical protein	0.0094	0.2277	0.3035
Echinococcus multilocularis	cyclins	0.0064	0.1526	0.1526
Trypanosoma brucei	Inositol phosphosphingolipids phospholipase C	0.0004	0.0021	0.0092
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0016	0.0305	0.1884
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0436	0.1913
Echinococcus multilocularis	translational activator gcn1	0.0005	0.005	0.005
Entamoeba histolytica	Ran family GTPase	0.0021	0.0439	0.1928
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0076	0.0335
Brugia malayi	cyclin fold protein 1 variant b	0.0016	0.0305	0.0623
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0016	0.0305	0.0623
Schistosoma mansoni	cyclin B3	0.0199	0.4891	0.4891
Loa Loa (eye worm)	cyclin fold protein 1 variant b	0.0016	0.0305	0.0406
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0439	0.0439
Schistosoma mansoni	ran	0.0021	0.0439	0.0439
Trichomonas vaginalis	cyclin D, putative	0.0064	0.1526	0.6702
Schistosoma mansoni	hypothetical protein	0.0005	0.0038	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0076	0.0335
Echinococcus granulosus	G1:S specific cyclin D1	0.0016	0.0305	0.0305
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0141	0.0141
Echinococcus multilocularis	CCR4 NOT transcription complex subunit 6	0.0004	0.0021	0.0021
Schistosoma mansoni	importin beta-1	0.0028	0.0627	0.0627
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0199	0.4891	0.4891
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0021	0.0436	0.1913
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0076	0.0335
Trypanosoma brucei	cyclin dependent kinase-binding protein, putative	0.0016	0.0305	0.1337
Loa Loa (eye worm)	cyclin domain-containing protein	0.0016	0.0305	0.0406
Echinococcus granulosus	transportin 1	0.0005	0.005	0.005
Loa Loa (eye worm)	cyclin domain-containing protein	0.0016	0.0305	0.0406
Schistosoma mansoni	hypothetical protein	0.0004	0.0021	0.0021
Schistosoma mansoni	hypothetical protein	0.0016	0.0305	0.0305
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0199	0.4891	1
Onchocerca volvulus	Cyclin L homolog	0.0016	0.0305	0.1337
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0016	0.0305	0.0623
Entamoeba histolytica	cyclin family protein	0.0064	0.1526	0.6702
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0038	0.005
Trypanosoma cruzi	mitotic cyclin, putative	0.0016	0.0305	0.1337
Echinococcus granulosus	cyclin G2	0.0016	0.0305	0.0305
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0135	0.018
Schistosoma mansoni	ap endonuclease	0.0021	0.0436	0.0436
Mycobacterium leprae	PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT	0.0003	0	0.5
Entamoeba histolytica	cyclin, domain containing protein	0.0016	0.0305	0.1337
Schistosoma mansoni	ap endonuclease	0.0021	0.0436	0.0436
Echinococcus granulosus	cyclin b3	0.0064	0.1526	0.1526
Echinococcus granulosus	inositol polyphosphate 5 phosphatase OCRL 1	0.0004	0.0021	0.0021
Echinococcus granulosus	cyclin A3 4	0.0016	0.0305	0.0305
Trichomonas vaginalis	cyclins, putative	0.0094	0.2277	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0009	0.0141	0.0188
Schistosoma mansoni	carbon catabolite repressor protein	0.0004	0.0021	0.0021
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0199	0.4891	0.4891
Trichomonas vaginalis	type II inositol 5-phosphatase, putative	0.0004	0.0021	0.0092
Schistosoma mansoni	cyclin B	0.0094	0.2277	0.2277
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0009	0.0141	0.0141
Echinococcus multilocularis	cyclin B	0.0094	0.2277	0.2277
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0021	0.0028
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0624	0.1276
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0305	0.1337
Entamoeba histolytica	cyclin, putative	0.0064	0.1526	0.6702
Trichomonas vaginalis	carbon catabolite repressor protein, putative	0.0004	0.0022	0.0097
Loa Loa (eye worm)	cyclin domain-containing protein	0.0016	0.0305	0.0406
Schistosoma mansoni	importin-beta 2	0.0005	0.005	0.005
Plasmodium vivax	hypothetical protein, conserved	0.0016	0.0305	0.4682
Echinococcus multilocularis	cyclins	0.0064	0.1526	0.1526
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0132	0.027
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0627	0.434
Toxoplasma gondii	hypothetical protein	0.0049	0.1138	0.7878
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0301	0.0401
Echinococcus granulosus	cyclin B3 1	0.0064	0.1526	0.1526
Echinococcus multilocularis	cyclin t1	0.0016	0.0305	0.0305
Loa Loa (eye worm)	MH1 domain-containing protein	0.0009	0.0141	0.0188
Loa Loa (eye worm)	MH1 domain-containing protein	0.0004	0.0017	0.0022
Plasmodium vivax	cyclin 4, putative	0.0016	0.0305	0.4682
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.1257	0.8706
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0094	0.2277	0.4656
Loa Loa (eye worm)	MH2 domain-containing protein	0.0132	0.3226	0.4299
Echinococcus granulosus	cpg binding protein	0.003	0.0664	0.0664
Echinococcus multilocularis	Cyclin L1	0.0016	0.0305	0.0305
Brugia malayi	hypothetical protein	0.0016	0.0305	0.0623
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0076	0.0335
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0492	0.2162
Echinococcus granulosus	synaptojanin 1	0.0004	0.0021	0.0021
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0005	0.0038	0.0038
Echinococcus multilocularis	oligomeric golgi complex subunit 3	0.0016	0.0305	0.0305
Trypanosoma cruzi	mitotic cyclin, putative	0.0016	0.0305	0.1337
Echinococcus multilocularis	cyclins	0.0064	0.1526	0.1526
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0016	0.0305	0.0623
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0092	0.0092
Brugia malayi	hypothetical protein	0.0016	0.0305	0.0623
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.1444	1
Trichomonas vaginalis	carbon catabolite repressor protein, putative	0.0004	0.0021	0.0092
Leishmania major	pantothenate kinase subunit, putative	0.0004	0.0021	0.0092
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0135	0.0135
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0021	0.0436	0.1913
Leishmania major	hypothetical protein, conserved	0.0004	0.0021	0.0092
Echinococcus granulosus	neutral sphingomyelinase	0.0004	0.0021	0.0021
Entamoeba histolytica	hypothetical protein	0.0023	0.0492	0.2162
Echinococcus granulosus	traf and tnf receptor associated protein	0.0004	0.0021	0.0021
Trichomonas vaginalis	carbon catabolite repressor protein, putative	0.0004	0.0021	0.0092
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0439	0.2778
Trypanosoma cruzi	cyclin, putative	0.0094	0.2277	1
Giardia lamblia	Cyclin fold protein 1, putative	0.0016	0.0305	0.1337
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0021	0.0436	0.3017
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0439	0.1928
Trypanosoma cruzi	cyclin 9, putative	0.0016	0.0305	0.1337
Schistosoma mansoni	neutral sphingomyelinase	0.0004	0.0021	0.0021
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0021	0.0043
Trichomonas vaginalis	cyclin B3, putative	0.0064	0.1526	0.6702
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.1418	0.1418
Schistosoma mansoni	hypothetical protein	0.0005	0.0038	0.0038
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0003	0.0002	0.0009
Echinococcus multilocularis	cyclin y	0.0016	0.0305	0.0305
Trichomonas vaginalis	helicase, putative	0.0006	0.0076	0.0335
Trichomonas vaginalis	cyclin B, putative	0.0094	0.2277	1
Onchocerca volvulus		0.0016	0.0305	0.1337
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0004	0.0021	0.0092
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0021	0.0043
Loa Loa (eye worm)	cyclin domain-containing protein	0.0016	0.0305	0.0406
Trypanosoma brucei	mitotic cyclin	0.0016	0.0305	0.1337
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0092	0.0092
Schistosoma mansoni	hypothetical protein	0.0403	1	1
Loa Loa (eye worm)	kap beta 3 protein	0.0005	0.005	0.0067
Trypanosoma brucei	Endonuclease/Exonuclease/phosphatase family, putative	0.0004	0.0021	0.0092
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.1444	1
Trichomonas vaginalis	cyclins, putative	0.0045	0.1056	0.4635
Echinococcus multilocularis	dnaJ subfamily B	0.0403	1	1
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0016	0.0305	0.0623
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0015	0.0301	0.0615
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.0436	0.0581
Trypanosoma cruzi	pantothenate kinase subunit, putative	0.0004	0.0021	0.0092
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0005	0.0038	0.0038
Echinococcus granulosus	oligomeric golgi complex subunit 3	0.0016	0.0305	0.0305
Trichomonas vaginalis	ran, putative	0.0021	0.0439	0.1928
Onchocerca volvulus		0.0004	0.0021	0.0092
Mycobacterium leprae	PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD	0.0003	0	0.5
Schistosoma mansoni	cyclin k	0.0016	0.0305	0.0305
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0009	0.0141	0.0141
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0004	0.0021	0.0144
Trichomonas vaginalis	conserved hypothetical protein	0.0003	0.0002	0.0009
Schistosoma mansoni	nocturnin	0.0004	0.0021	0.0021
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0009	0.0141	0.0141
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0439	0.0585
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.0436	0.0891
Brugia malayi	MH1 domain containing protein	0.0009	0.0141	0.0289
Trypanosoma cruzi	endonuclease/exonuclease/phosphatase, putative	0.0004	0.0021	0.0092
Leishmania major	mitotic cyclin, putative	0.0016	0.0305	0.1337
Plasmodium vivax	cyclin dependent kinase binding protein, putative	0.0016	0.0305	0.4682
Loa Loa (eye worm)	cyclin domain-containing protein	0.0016	0.0305	0.0406
Echinococcus granulosus	cyclin G2	0.0016	0.0305	0.0305
Loa Loa (eye worm)	hypothetical protein	0.003	0.0667	0.0889
Schistosoma mansoni	hypothetical protein	0.0005	0.0038	0.0038
Loa Loa (eye worm)	MH2 domain-containing protein	0.0004	0.0017	0.0022
Schistosoma mansoni	cyclins	0.0064	0.1526	0.1526
Trichomonas vaginalis	skeletal muscle/kidney enriched inositol 5-phosphatase, putative	0.0004	0.0021	0.0092
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0627	0.2752
Brugia malayi	Cytochrome P450 family protein	0.0004	0.0011	0.0022
Echinococcus granulosus	cyclin B	0.0094	0.2277	0.2277
Brugia malayi	MH2 domain containing protein	0.0132	0.3226	0.6595
Trypanosoma cruzi	Inositol phosphosphingolipids phospholipase C	0.0004	0.0021	0.0092
Echinococcus granulosus	cyclins	0.0064	0.1526	0.1526
Echinococcus granulosus	smad	0.0009	0.0141	0.0141
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0439	0.6903
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.0436	0.0436
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0305	0.1337
Entamoeba histolytica	endonuclease/exonuclease/phosphatase domain containing protein	0.0004	0.0021	0.0092
Echinococcus multilocularis	G1:S specific cyclin D1	0.0016	0.0305	0.0305
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0004	0.0021	0.0092
Brugia malayi	RNA, U transporter 1	0.0081	0.1937	0.3961
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0492	0.2162
Leishmania major	cytochrome p450-like protein	0.0004	0.0011	0.0048
Brugia malayi	MH2 domain containing protein	0.0009	0.0141	0.0289
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0305	0.1337
Plasmodium falciparum	cyclin 1	0.0016	0.0305	0.1884
Echinococcus multilocularis	cyclins	0.0064	0.1526	0.1526
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0076	0.0335
Trypanosoma brucei	ULK family serine/threonine-protein kinase, putative	0.0005	0.0053	0.0232
Schistosoma mansoni	Smad4	0.0009	0.0141	0.0141
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0076	0.0335
Echinococcus multilocularis	cyclin y	0.0016	0.0305	0.0305
Giardia lamblia	G2/mitotic-specific cyclin B	0.0094	0.2277	1
Schistosoma mansoni	cyclin G	0.0016	0.0305	0.0305
Echinococcus multilocularis	traf and tnf receptor associated protein	0.0004	0.0021	0.0021
Brugia malayi	MH2 domain containing protein	0.0009	0.0141	0.0289
Trypanosoma cruzi	inositol 5-phosphatase 1, putative	0.0004	0.0021	0.0092
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0004	0.0011	0.0075
Schistosoma mansoni	cyclin d	0.0016	0.0305	0.0305
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0092	0.0092
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0439	0.1928
Echinococcus multilocularis	inositol polyphosphate 5 phosphatase OCRL 1	0.0004	0.0021	0.0021
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0021	0.0436	0.1913
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0004	0.0021	0.0092
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.1444	0.1444
Schistosoma mansoni	hypothetical protein	0.0016	0.0305	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0021	0.0028
Leishmania major	inositol phosphosphingolipid phospholipase C-Like	0.0004	0.0021	0.0092
Trypanosoma brucei	cyclin 3	0.0016	0.0305	0.1337
Schistosoma mansoni	cpg binding protein	0.0028	0.0624	0.0624
Onchocerca volvulus		0.0028	0.0624	0.274
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.1444	1
Giardia lamblia	Cyclin A	0.0064	0.1526	0.6702
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0627	0.0627
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.1444	0.6342
Echinococcus multilocularis	cyclins	0.0064	0.1526	0.1526
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0141	0.0141
Trichomonas vaginalis	cyclins, putative	0.0016	0.0305	0.1337
Schistosoma mansoni	cpg binding protein	0.003	0.0664	0.0664
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0305	0.1337
Echinococcus granulosus	cyclins	0.0064	0.1526	0.1526
Trichomonas vaginalis	cyclin D, putative	0.0016	0.0305	0.1337
Trichomonas vaginalis	cyclins, putative	0.0094	0.2277	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0179	0.0239
Trichomonas vaginalis	cyclin B, putative	0.0094	0.2277	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.2 uM	Inhibitory activity against Cyclin-dependent kinase 2-cyclin E	ChEMBL.	12824044
IC50 (binding)	= 0.2 uM	Inhibitory activity against Cyclin-dependent kinase 2-cyclin E	ChEMBL.	12824044
IC50 (binding)	= 0.23 uM	Inhibition of Cyclin-dependent kinase 1-cyclin B	ChEMBL.	12824044
IC50 (binding)	= 0.23 uM	Inhibition of Cyclin-dependent kinase 1-cyclin B	ChEMBL.	12824044

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 5329769

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 131969