Detailed information for compound 132559

Basic information

Technical information
  • TDR Targets ID: 132559
  • Name: (7S,8S)-7,8-dichloro-6-ethyl-5-hydroxy-6,7,8, 9-tetrahydro-1H-1-benzazepine-2,3-dione
  • MW: 290.143 | Formula: C12H13Cl2NO3
  • H donors: 2 H acceptors: 3 LogP: 1.31 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC1[C@H](Cl)[C@@H](Cl)Cc2c1c(O)cc(=O)c(=O)[nH]2
  • InChi: 1S/C12H13Cl2NO3/c1-2-5-10-7(3-6(13)11(5)14)15-12(18)9(17)4-8(10)16/h4-6,11,16H,2-3H2,1H3,(H,15,17,18)/t5?,6-,11-/m0/s1
  • InChiKey: PBSUDJYMQMKKKP-CVAYCHMDSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (7S,8S)-7,8-dichloro-6-ethyl-5-hydroxy-6,7,8,9-tetrahydro-1H-1-benzazepine-2,3-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0011 0.0037
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.3078 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0204 0.0408
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0358 0.0358
Brugia malayi beta-lactamase 0.0035 0.0325 0.1021
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0256 0.3078 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0484 0.0949
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0011 0.0023
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0247 0.0804
Loa Loa (eye worm) hypothetical protein 0.004 0.0389 0.1265
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.4989 0.4989
Schistosoma mansoni hypothetical protein 0.029 0.3505 0.7018
Mycobacterium tuberculosis Possible lysophospholipase 0.0068 0.0732 0.0894
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0011 0.0023
Echinococcus multilocularis zinc finger protein 0.0022 0.0165 0.0165
Mycobacterium ulcerans 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD 0.0407 0.4963 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0566 0.184
Schistosoma mansoni thyroid hormone receptor 0.0132 0.1534 0.3058
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.2094 0.6427
Echinococcus granulosus dnaJ subfamily B 0.0409 0.4989 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0811 0.2636
Plasmodium falciparum lysophospholipase, putative 0.0068 0.0732 1
Leishmania major hypothetical protein, conserved 0.0027 0.0222 0.2065
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0566 0.181
Schistosoma mansoni zinc finger protein 0.0022 0.0165 0.0308
Onchocerca volvulus Glucosylceramidase homolog 0.0168 0.1981 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0086 0.0172
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0068 0.0732 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0011 0.0023
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0498 0.1588
Schistosoma mansoni bromodomain containing protein 0.0068 0.0735 0.1453
Schistosoma mansoni thyroid hormone receptor 0.0132 0.1534 0.3058
Mycobacterium tuberculosis 4,9-DHSA hydrolase 0.04 0.4882 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0566 0.0566
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.2875 0.5762
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0204 0.0204
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0023 0.0039
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0325 0.3668
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.3078 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0037
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1981 0.6017
Onchocerca volvulus 0.0035 0.0325 0.159
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0646 0.0694
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0732 0.148
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.2875 0.2875
Brugia malayi PHD-finger family protein 0.0028 0.0234 0.0727
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0566 0.1115
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0325 0.3668
Brugia malayi Bromodomain containing protein 0.004 0.0388 0.123
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0119 0.0119
Schistosoma mansoni hypothetical protein 0.0016 0.0089 0.0155
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0037
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0011 0.0023
Schistosoma mansoni hypothetical protein 0.0016 0.0086 0.015
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0511 0.1629
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0011 0.0037
Schistosoma mansoni hypothetical protein 0.0012 0.0038 0.0054
Schistosoma mansoni hypothetical protein 0.0016 0.0086 0.015
Brugia malayi hypothetical protein 0.0027 0.0222 0.0685
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0222 0.2065
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0037
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0068 0.0732 0.148
Echinococcus granulosus GPCR family 2 0.0016 0.0086 0.0172
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.2094 0.6427
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0011 0.0011
Trypanosoma brucei monoglyceride lipase, putative 0.0068 0.0732 1
Trypanosoma brucei monoglyceride lipase, putative 0.0068 0.0732 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0068 0.0732 0.148
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0325 0.0629
Plasmodium falciparum lysophospholipase, putative 0.0068 0.0732 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.0247 0.0769
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.012 0.0388
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0325 0.0325
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0325 0.1055
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0325 0.1021
Echinococcus granulosus tumor protein p63 0.0353 0.4294 0.8607
Leishmania major monoglyceride lipase, putative 0.0068 0.0732 1
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.1463 0.4754
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0037
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0011 0.0037
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.2671 0.5148
Schistosoma mansoni hypothetical protein 0.0122 0.1412 0.2813
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0325 0.0629
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0188 0.2233 0.4476
Plasmodium falciparum esterase, putative 0.0068 0.0732 1
Schistosoma mansoni hypothetical protein 0.0409 0.4989 1
Onchocerca volvulus 0.0029 0.0247 0.1197
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0188 0.2233 0.2233
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0068 0.0732 0.5
Trypanosoma cruzi monoglyceride lipase, putative 0.0068 0.0732 1
Brugia malayi hypothetical protein 0.0239 0.2875 0.9339
Echinococcus granulosus cpg binding protein 0.0032 0.0293 0.0587
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0011 0.0037
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0068 0.0732 0.5
Schistosoma mansoni hypothetical protein 0.0022 0.0158 0.0295
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0011 0.0037
Plasmodium falciparum lysophospholipase, putative 0.0068 0.0732 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0511 0.166
Schistosoma mansoni hypothetical protein 0.0016 0.0086 0.015
Schistosoma mansoni hypothetical protein 0.0016 0.0086 0.015
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0646 0.1295
Brugia malayi Bromodomain containing protein 0.008 0.0887 0.2857
Loa Loa (eye worm) hypothetical protein 0.0046 0.0466 0.1513
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1981 0.6017
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0119 0.0239
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0566 0.0566
Loa Loa (eye worm) hypothetical protein 0.0043 0.042 0.1366
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0011 0.0037
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0011 0.0023
Echinococcus multilocularis thyroid hormone receptor alpha 0.0132 0.1534 0.1534
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0484 0.097
Loa Loa (eye worm) beta-lactamase 0.0035 0.0325 0.1055
Loa Loa (eye worm) hypothetical protein 0.0035 0.0325 0.1055
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0011 0.0011
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0038 0.0077
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0037
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.0688 0.0688
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0037
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0646 0.0694
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0222 0.2065
Loa Loa (eye worm) hypothetical protein 0.0035 0.0325 0.1055
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0484 0.2399
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0086 0.0172
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0011 0.0023
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1981 0.6017
Echinococcus granulosus zinc finger protein 0.0022 0.0165 0.033
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.3078 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0325 0.202
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0484 0.0484
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0068 0.0732 0.148
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0112 0.0112
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0646 0.1275
Schistosoma mansoni hypothetical protein 0.0034 0.0314 0.0608
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0068 0.0732 0.148
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0011 0.0037
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0086 0.0086
Brugia malayi beta-lactamase family protein 0.0035 0.0325 0.1021
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0484 0.097
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0646 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.0688 0.1379
Loa Loa (eye worm) hypothetical protein 0.0035 0.0325 0.1055
Toxoplasma gondii ABC1 family protein 0.0035 0.0325 0.2427
Loa Loa (eye worm) hypothetical protein 0.0018 0.0119 0.0388
Loa Loa (eye worm) hypothetical protein 0.0027 0.0222 0.072
Brugia malayi MH2 domain containing protein 0.0126 0.1463 0.4734
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0534 0.105
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0646 0.8669
Loa Loa (eye worm) hypothetical protein 0.0048 0.0484 0.1573
Schistosoma mansoni cpg binding protein 0.0032 0.0293 0.0565
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0222 0.2065
Loa Loa (eye worm) hypothetical protein 0.0052 0.0534 0.1735
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0325 0.0651
Echinococcus multilocularis GPCR, family 2 0.0016 0.0086 0.0086
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0646 0.0706
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.1412 0.1412
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0086 0.0279
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0068 0.0732 0.148
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0732 0.148
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0646 0.1275
Echinococcus granulosus FTZ F1 alpha 0.001 0.0011 0.0023
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0011 0.0037
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0598 0.8874
Schistosoma mansoni cpg binding protein 0.0032 0.0293 0.0565
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1981 0.6017
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0484 0.0484
Onchocerca volvulus 0.0035 0.0325 0.159
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0011 0.0011
Brugia malayi beta-lactamase family protein 0.0035 0.0325 0.1021
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0037
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0068 0.0732 0.148
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0112 0.0201
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0038 0.0038
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0011 0.0011
Schistosoma mansoni survival motor neuron protein 0.0049 0.0498 0.0978
Loa Loa (eye worm) hypothetical protein 0.0239 0.2875 0.9341
Echinococcus multilocularis tumor protein p63 0.0353 0.4294 0.4294
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0011 0.0023
Onchocerca volvulus 0.0049 0.0498 0.2471
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0158 0.0514
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0511 0.1629
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.1412 0.2829
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0086 0.0243
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0011 0.0011
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0112 0.0201
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.3078 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0325 0.1055
Onchocerca volvulus 0.0048 0.0484 0.2399
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0566 0.1135
Loa Loa (eye worm) MBCTL1 0.0054 0.0566 0.184
Mycobacterium ulcerans hypothetical protein 0.0068 0.0732 0.0878
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0011 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1981 0.6017
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0646 0.0694
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0204 0.0386
Loa Loa (eye worm) hypothetical protein 0.0034 0.0314 0.1021
Echinococcus multilocularis cpg binding protein 0.0032 0.0293 0.0293
Loa Loa (eye worm) hypothetical protein 0.0035 0.0325 0.1055
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0484 0.0949
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.1463 0.4754
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0325 0.3668
Brugia malayi mbt repeat family protein 0.0048 0.0484 0.1541
Leishmania major hypothetical protein, conserved 0.0035 0.0325 0.3668
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0256 0.3078 1
Schistosoma mansoni cpg binding protein 0.0029 0.0247 0.0474
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0358 0.0717
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0484 0.1573
Schistosoma mansoni zinc finger protein 0.0016 0.0089 0.0155
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0086 0.0086
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0314 0.0987
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0011 0.0023
Brugia malayi hypothetical protein 0.0017 0.0104 0.0301
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0112 0.0224
Mycobacterium ulcerans lysophospholipase 0.0068 0.0732 0.0878
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0646 0.0646
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0119 0.0217
Loa Loa (eye worm) hypothetical protein 0.0035 0.0325 0.1055
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0484 0.0949
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0011 0.0011
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0086 0.0243
Plasmodium vivax PST-A protein 0.0068 0.0732 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0649 0.128
Loa Loa (eye worm) hypothetical protein 0.0016 0.0086 0.0279
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0119 0.0217
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.3078 1
Onchocerca volvulus 0.0052 0.0534 0.2653
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0566 0.1135
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1981 0.6017
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.3078 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0511 0.166
Schistosoma mansoni hypothetical protein 0.0049 0.0498 0.0978
Onchocerca volvulus 0.0035 0.0325 0.159
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1981 0.6017
Brugia malayi mbt repeat family protein 0.0048 0.0484 0.1541
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0011 0.0011

Activities

Activity type Activity value Assay description Source Reference
Kb (binding) = 0.0028 uM Inhibition of N-methyl-D-aspartate glutamate receptor was measured in oocytes expressing cloned rat brain receptor subunits (NR1A/2C) ChEMBL. 9240357
Kb (binding) = 0.0028 uM Inhibition of N-methyl-D-aspartate glutamate receptor was measured in oocytes expressing cloned rat brain receptor subunits (NR1A/2C) ChEMBL. 9240357
Kb (binding) = 0.72 uM Inhibition of Ionotropic glutamate receptor AMPA-preferring non-NMDA receptors was measured in oocytes expressing rat brain poly(A)+ RNA isolatedfrom the cerebral cortex. ChEMBL. 9240357
Kb (binding) = 0.72 uM Inhibition of Ionotropic glutamate receptor AMPA-preferring non-NMDA receptors was measured in oocytes expressing rat brain poly(A)+ RNA isolatedfrom the cerebral cortex. ChEMBL. 9240357
Selectivity index (binding) = 260 Selectivity index measured as the kb ratio of AMPA to that of NMDA. ChEMBL. 9240357

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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