Detailed information for compound 1327288

Basic information

Technical information
  • TDR Targets ID: 1327288
  • Name: 8-amino-7-(4-phenyl-1,3-thiazol-2-yl)-10-sulf anyl-9-azaspiro[5.5]undeca-8,10-diene-11-carb onitrile
  • MW: 380.53 | Formula: C20H20N4S2
  • H donors: 1 H acceptors: 2 LogP: 4.12 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1=C(S)N=C(C(C21CCCCC2)c1scc(n1)c1ccccc1)N
  • InChi: 1S/C20H20N4S2/c21-11-14-18(25)24-17(22)16(20(14)9-5-2-6-10-20)19-23-15(12-26-19)13-7-3-1-4-8-13/h1,3-4,7-8,12,16,25H,2,5-6,9-10H2,(H2,22,24)
  • InChiKey: UWPXIEPPMYTAMU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-amino-7-(4-phenylthiazol-2-yl)-10-sulfanyl-9-azaspiro[5.5]undeca-8,10-diene-11-carbonitrile
  • 8-amino-10-mercapto-7-(4-phenyl-2-thiazolyl)-9-azaspiro[5.5]undeca-8,10-diene-11-carbonitrile
  • 8-amino-10-mercapto-7-(4-phenylthiazol-2-yl)-9-azaspiro[5.5]undeca-8,10-diene-11-carbonitrile
  • A2518/0107018
  • TimTec1_005824
  • MLS000070137
  • 4-Imino-2-mercapto-5-(4-phenyl-thiazol-2-yl)-3-aza-spiro[5.5]undec-1-ene-1-carbonitrile
  • BAS 04796151
  • SMR000120734

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens runt-related transcription factor 1 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens core-binding factor, beta subunit No references
Staphylococcus aureus (strain N315) Probable nicotinate-nucleotide adenylyltransferase Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Babesia bovis cytidylyltransferase family protein Get druggable targets OG5_131883 All targets in OG5_131883
Treponema pallidum hypothetical protein Get druggable targets OG5_131883 All targets in OG5_131883
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein Get druggable targets OG5_131883 All targets in OG5_131883
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC Get druggable targets OG5_131883 All targets in OG5_131883
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium berghei nicotinamide/nicotinic acid mononucleotide adenylyltransferase, putative Get druggable targets OG5_131883 All targets in OG5_131883
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva hypothetical protein, conserved Get druggable targets OG5_131883 All targets in OG5_131883
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic Get druggable targets OG5_131883 All targets in OG5_131883
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative Get druggable targets OG5_131883 All targets in OG5_131883
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase Get druggable targets OG5_131883 All targets in OG5_131883
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi nicotinamide/nicotinic acid mononucleotide adenylyltransferase, putative Get druggable targets OG5_131883 All targets in OG5_131883
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium yoelii Predicted nucleotidyltransferase, putative Get druggable targets OG5_131883 All targets in OG5_131883
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Get druggable targets OG5_133916 All targets in OG5_133916
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei variant surface glycoprotein (VSG, atypical), putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 171 aa 20.5 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Giardia lamblia Nicotinamide-nucleotide adenylyltransferase Probable nicotinate-nucleotide adenylyltransferase   189 aa 153 aa 24.2 %
Trypanosoma cruzi hypothetical protein, conserved Probable nicotinate-nucleotide adenylyltransferase   189 aa 200 aa 20.5 %
Trichomonas vaginalis nicotinamide mononucleotide adenylyltransferase, putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 205 aa 19.0 %
Trichomonas vaginalis nicotinamide mononucleotide adenylyltransferase, putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 210 aa 23.8 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Entamoeba histolytica NMN adenylyltransferase, putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 204 aa 24.5 %
Trypanosoma cruzi hypothetical protein, conserved Probable nicotinate-nucleotide adenylyltransferase   189 aa 200 aa 21.0 %
Entamoeba histolytica nicotinamide nucleotide adenylyltransferase, putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 204 aa 24.5 %
Plasmodium knowlesi cytoskeleton associated protein, putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 170 aa 23.5 %
Giardia lamblia Nicotinamide-nucleotide adenylyltransferase Probable nicotinate-nucleotide adenylyltransferase   189 aa 247 aa 20.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0087 0.0832 0.1118
Entamoeba histolytica hypothetical protein 0.0185 0.1999 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0607 0.7051 0.7223
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.0557 0.0566
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.0457 0.0643
Brugia malayi Pre-SET motif family protein 0.0089 0.086 0.1195
Schistosoma mansoni ran 0.0044 0.0319 0.0322
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0554 0.0744
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0254 0.025
Loa Loa (eye worm) fli-1 protein 0.0214 0.2353 0.3163
Echinococcus granulosus lysine specific demethylase 5A 0.0046 0.0344 0.0348
Echinococcus multilocularis importin subunit beta 1 0.006 0.0508 0.0504
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0319 0.2378
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.1171 0.1167
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0175 0.0235
Echinococcus granulosus expressed protein 0.0026 0.0103 0.0101
Echinococcus multilocularis thyroid hormone receptor alpha 0.028 0.3136 0.3133
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0149 0.1575 0.161
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.1038 0.236
Echinococcus granulosus zinc finger protein 0.0022 0.0055 0.0052
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.0457 0.0643
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0254 0.0256
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0345 0.3914 1
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0345 0.3914 1
Echinococcus multilocularis cpg binding protein 0.0031 0.0167 0.0163
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.03 0.0144
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0026 0.0103 0.0101
Schistosoma mansoni hypothetical protein 0.0639 0.7442 0.7623
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0607 0.7051 0.705
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.1177 0.2521
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0537 0.0545
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0026 0.0103 0.0143
Mycobacterium leprae Probable lipase LipE 0.0039 0.0254 0.0278
Loa Loa (eye worm) hypothetical protein 0.0535 0.619 0.8318
Toxoplasma gondii LsmAD domain-containing protein 0.0056 0.0457 0.4328
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0149 0.1575 0.1571
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0319 0.0204
Schistosoma mansoni thyroid hormone receptor 0.028 0.3136 0.3209
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0508 0.0804
Brugia malayi Probable ClpP-like protease 0.0087 0.0832 0.1155
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0254 0.0186
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0026 0.0103 0.0143
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.1038 0.2141
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0175 0.0243
Brugia malayi hypothetical protein 0.0056 0.0457 0.0635
Loa Loa (eye worm) hypothetical protein 0.0149 0.1575 0.2116
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0139
Loa Loa (eye worm) hypothetical protein 0.0039 0.0254 0.0342
Loa Loa (eye worm) hypothetical protein 0.0032 0.0175 0.0235
Loa Loa (eye worm) hypothetical protein 0.006 0.0513 0.069
Onchocerca volvulus 0.0033 0.0181 0.0096
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0887 0.0905
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0175 0.0235
Brugia malayi hypothetical protein 0.0185 0.1999 0.2776
Brugia malayi glutathione reductase 0.0046 0.0338 0.0469
Toxoplasma gondii hypothetical protein 0.0049 0.0375 0.3164
Loa Loa (eye worm) jmjC domain-containing protein 0.0046 0.0344 0.0462
Loa Loa (eye worm) hypothetical protein 0.0039 0.0254 0.0342
Leishmania major trypanothione reductase 0.0046 0.0338 0.0264
Schistosoma mansoni hypothetical protein 0.0149 0.1575 0.161
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0175 0.0175
Echinococcus granulosus GPCR family 2 0.0149 0.1575 0.161
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0026 0.0103 0.0101
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0554 0.0563
Onchocerca volvulus 0.0032 0.0175 0.0088
Schistosoma mansoni thyroid hormone receptor 0.028 0.3136 0.3209
Entamoeba histolytica hypothetical protein 0.0185 0.1999 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.024 0.0236
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0175 0.0175
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0319 0.0449
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0338 0.0454
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.0635 0.0647
Toxoplasma gondii thioredoxin reductase 0.0046 0.0338 0.2647
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0488 0.0677
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0026 0.0103 0.0143
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0607 0.7051 0.7223
Plasmodium vivax ataxin-2 like protein, putative 0.0056 0.0457 0.0817
Loa Loa (eye worm) hypothetical protein 0.0033 0.0181 0.0243
Loa Loa (eye worm) MH2 domain-containing protein 0.0244 0.2707 0.3638
Loa Loa (eye worm) hypothetical protein 0.0032 0.0175 0.0235
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0149 0.1575 0.2187
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.1038 0.2141
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0212 0.0167
Brugia malayi hypothetical protein 0.0026 0.0103 0.0143
Brugia malayi G-protein alpha subunit 0.0026 0.0103 0.0143
Echinococcus granulosus snurportin 1 0.0639 0.7442 0.7623
Brugia malayi nuclear hormone receptor 0.0032 0.0175 0.0243
Brugia malayi beta-lactamase family protein 0.0039 0.0254 0.0353
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0026 0.0103 0.0099
Schistosoma mansoni cpg binding protein 0.0031 0.0167 0.0167
Loa Loa (eye worm) runx1 0.0067 0.0594 0.0798
Echinococcus granulosus tumor protein p63 0.037 0.4223 0.4324
Echinococcus granulosus lamin 0.0033 0.0181 0.0181
Brugia malayi jmjC domain containing protein 0.0115 0.1171 0.1626
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0175 0.0243
Trypanosoma brucei PAB1-binding protein , putative 0.0056 0.0457 0.0643
Schistosoma mansoni lozenge 0.0067 0.0594 0.0604
Schistosoma mansoni ets-related 0.0214 0.2353 0.2408
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0087 0.0832 1
Plasmodium vivax glutathione reductase, putative 0.0046 0.0338 0.05
Echinococcus multilocularis snurportin 1 0.0639 0.7442 0.744
Plasmodium vivax importin-beta 2, putative 0.006 0.0508 0.0952
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0087 0.0832 0.0848
Brugia malayi beta-lactamase 0.0039 0.0254 0.0353
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0181 0.0251
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0338 0.05
Onchocerca volvulus 0.0535 0.619 0.7497
Brugia malayi Ets-domain containing protein 0.0071 0.0635 0.0882
Trypanosoma brucei trypanothione reductase 0.0046 0.0338 0.0264
Loa Loa (eye worm) hypothetical protein 0.0032 0.0175 0.0235
Schistosoma mansoni hypothetical protein 0.0185 0.1999 0.2044
Brugia malayi Fli-1 protein 0.0214 0.2353 0.3269
Brugia malayi Thioredoxin reductase 0.0046 0.0338 0.0469
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0175 0.0235
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0175 0.0235
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0488 0.0637
Plasmodium falciparum thioredoxin reductase 0.0046 0.0338 0.05
Schistosoma mansoni importin beta-1 0.006 0.0508 0.0516
Brugia malayi intermediate filament protein 0.0033 0.0181 0.0251
Loa Loa (eye worm) hypothetical protein 0.006 0.0513 0.0689
Brugia malayi Pre-SET motif family protein 0.0619 0.72 1
Entamoeba histolytica hypothetical protein 0.0049 0.0372 0.142
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0832 0.1812
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0639 0.7442 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.1073 0.1442
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0175 0.0243
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.024 0.0242
Brugia malayi Bromodomain containing protein 0.0038 0.0242 0.0336
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0181 0.0243
Toxoplasma gondii ABC1 family protein 0.0039 0.0254 0.1475
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0554 0.0744
Brugia malayi nuclear receptor NHR-88 0.0032 0.0175 0.0243
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0508 0.0804
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0554 0.0563
Echinococcus multilocularis lamin dm0 0.0033 0.0181 0.0177
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.1177 0.2729
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.0372 0.0374
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0377 0.0373
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.03 0.0144
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0026 0.0103 0.0139
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0175 0.0171
Brugia malayi latrophilin 2 splice variant baaae 0.0322 0.3645 0.5062
Plasmodium vivax SET domain protein, putative 0.0089 0.086 0.1888
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.0319 0.386
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.0488 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0087 0.0836 0.1123
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0087 0.0832 0.1812
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0254 0.0278
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0488 0.0474
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.044 0.0446
Brugia malayi PHD-finger family protein 0.0028 0.0122 0.0169
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0607 0.7051 0.7223
Echinococcus granulosus geminin 0.0361 0.4105 0.4203
Schistosoma mansoni hypothetical protein 0.0022 0.0049 0.0046
Schistosoma mansoni hypothetical protein 0.0247 0.2752 0.2816
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0026 0.0103 0.0101
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.1038 0.2141
Schistosoma mansoni hypothetical protein 0.0025 0.009 0.0088
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0185 0.1999 0.2044
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0051 0.0047
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0149 0.1575 0.161
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0338 0.0333
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0107 0.1073 0.1096
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0175 0.0243
Loa Loa (eye worm) glutathione reductase 0.0046 0.0338 0.0454
Loa Loa (eye worm) hypothetical protein 0.0032 0.0175 0.0235
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0411 0.0496
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0026 0.0103 0.0101
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0254 0.0342
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0087 0.0832 0.9598
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0175 0.0243
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0087 0.0832 0.1812
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0488 0.0483
Echinococcus multilocularis tumor protein p63 0.037 0.4223 0.422
Trichomonas vaginalis esterase, putative 0.0039 0.0254 0.0186
Echinococcus multilocularis peregrin 0.0038 0.0242 0.0238
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0026 0.0103 0.0101
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.03 0.0144
Onchocerca volvulus 0.0054 0.044 0.0415
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0175 0.0243
Loa Loa (eye worm) beta-lactamase 0.0039 0.0254 0.0342
Schistosoma mansoni transcription factor LCR-F1 0.0185 0.1999 0.2044
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0338 0.0228
Brugia malayi ecdysteroid receptor 0.0032 0.0175 0.0243
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0488 0.0898
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0345 0.3914 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0319 0.0443
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0247 0.2752 0.2749
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0345 0.3914 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0057 0.0473 0.0598
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.1177 0.2521
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.1038 0.2141
Echinococcus multilocularis GPCR, family 2 0.0149 0.1575 0.1571
Leishmania major hypothetical protein, conserved 0.0056 0.0457 0.0643
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0254 0.0278
Entamoeba histolytica hypothetical protein 0.0185 0.1999 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.3407 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0107 0.1073 0.1069
Mycobacterium ulcerans hypothetical protein 0.0159 0.1696 0.3939
Schistosoma mansoni ap endonuclease 0.0058 0.0488 0.0495
Schistosoma mansoni gabp alpha 0.0071 0.0635 0.0647
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.0635 0.0854
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0607 0.7051 0.9793
Brugia malayi hypothetical protein 0.0087 0.0836 0.1161
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0124 0.0167
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0092 0.009
Onchocerca volvulus Alhambra homolog 0.0035 0.0212 0.0135
Brugia malayi Calcitonin receptor-like protein seb-1 0.0471 0.5429 0.7539
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0175 0.0171
Echinococcus multilocularis peptidase Clp (S14 family) 0.0057 0.0473 0.0469
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0139
Loa Loa (eye worm) transcription factor SMAD2 0.0244 0.2707 0.3638
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0149 0.1575 0.1571
Leishmania major importin beta-1 subunit, putative 0.0049 0.0372 0.0374
Loa Loa (eye worm) hypothetical protein 0.0032 0.0175 0.0235
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.9761 0.9761
Loa Loa (eye worm) latrophilin receptor protein 2 0.0149 0.1575 0.2116
Schistosoma mansoni hypothetical protein 0.0149 0.1575 0.161
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0377 0.0382
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.9761 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0175 0.0235
Onchocerca volvulus 0.0033 0.0181 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0254 0.0342
Loa Loa (eye worm) hypothetical protein 0.0046 0.0343 0.0461
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0488 0.074
Brugia malayi F/Y-rich N-terminus family protein 0.0025 0.0094 0.013
Echinococcus granulosus importin subunit beta 1 0.006 0.0508 0.0516
Loa Loa (eye worm) G protein alpha subunit 3 0.0026 0.0103 0.0139
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0175 0.0175
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0254 0.0186
Brugia malayi CXXC zinc finger family protein 0.0028 0.0124 0.0173
Schistosoma mansoni eyes absent homolog 0.0087 0.0836 0.0852
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.0635 0.0631
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0175 0.0175
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0554 0.055
Schistosoma mansoni bromodomain containing protein 0.0068 0.0601 0.0612
Onchocerca volvulus 0.0039 0.0254 0.0186
Plasmodium falciparum glutathione reductase 0.0046 0.0338 0.05
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0175 0.0243
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0319 0.0204
Loa Loa (eye worm) hypothetical protein 0.0074 0.0675 0.0908
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0026 0.0103 0.0101
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0175 0.0171
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0254 0.0256
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0175 0.0243
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0175 0.0171
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0175 0.0171
Loa Loa (eye worm) hypothetical protein 0.0535 0.619 0.8318
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0181 0.0243
Loa Loa (eye worm) hypothetical protein 0.0054 0.044 0.0591
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0026 0.0103 0.0143
Brugia malayi RNA binding protein 0.0064 0.0554 0.0769
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0175 0.0243
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0319 0.0449
Loa Loa (eye worm) hypothetical protein 0.0471 0.5429 0.7295
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0338 0.0264
Loa Loa (eye worm) hypothetical protein 0.0087 0.0836 0.1123
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0301 0.0297
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0026 0.0103 0.0143
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0175 0.0175
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0175 0.0175
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.1503 0.3959
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0619 0.72 0.9676
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0247 0.2751 0.6821
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0089 0.086 0.0856
Loa Loa (eye worm) hypothetical protein 0.0322 0.3645 0.4898
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0175 0.0243
Echinococcus granulosus intermediate filament protein 0.0033 0.0181 0.0181
Schistosoma mansoni hypothetical protein 0.0149 0.1575 0.161
Schistosoma mansoni cpg binding protein 0.0028 0.0124 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0175 0.0243
Schistosoma mansoni cpg binding protein 0.0031 0.0167 0.0167
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0185 0.1999 0.1995
Loa Loa (eye worm) hypothetical protein 0.0056 0.0457 0.0614
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0175 0.0088
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0175 0.0235
Echinococcus multilocularis Protein lozenge 0.0067 0.0594 0.059
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0661 0.0888
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0175 0.0175
Toxoplasma gondii exonuclease III APE 0.0058 0.0488 0.4757
Loa Loa (eye worm) hypothetical protein 0.0032 0.0175 0.0235
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0175 0.0235
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0488 0.074
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0488 0.0655
Leishmania major GTP-binding protein, putative 0.0044 0.0319 0.0204
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0026 0.0103 0.0101
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0212 0.0883
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0254 0.0186
Plasmodium falciparum importin beta, putative 0.006 0.0508 0.0952
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0554 0.0563
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0554 0.0563
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0087 0.0832 0.1812
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0607 0.7051 0.9476
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0175 0.0175
Brugia malayi Bromodomain containing protein 0.008 0.0748 0.1039
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0372 0.0332
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0087 0.0832 0.1577
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0139
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0089 0.086 0.0877
Schistosoma mansoni hypothetical protein 0.0149 0.1575 0.161
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0175 0.0175
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0026 0.0103 0.0139
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0026 0.0103 0.0099
Schistosoma mansoni GTP-binding protein alpha subunit 0.0026 0.0103 0.0101
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0212 0.0208
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0092 0.009
Toxoplasma gondii HEAT repeat-containing protein 0.006 0.0508 0.5041
Onchocerca volvulus 0.0039 0.0254 0.0186
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.3407 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0254 0.0342
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0254 0.0256
Loa Loa (eye worm) hypothetical protein 0.0032 0.0174 0.0234
Entamoeba histolytica Ran family GTPase 0.0044 0.0319 0.1137
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0488 0.2029
Schistosoma mansoni zinc finger protein 0.0022 0.0055 0.0052
Onchocerca volvulus 0.0039 0.0254 0.0186
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0092 0.0088
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0254 0.0353
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0175 0.0088
Mycobacterium tuberculosis Probable reductase 0.0104 0.1038 0.2141
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0026 0.0103 0.0139
Onchocerca volvulus 0.0089 0.086 0.0932
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.1696 0.3939
Onchocerca volvulus 0.0028 0.0124 0.0026
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0488 0.074
Schistosoma mansoni hypothetical protein 0.0322 0.3645 0.3731
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0085 0.0814 0.083
Echinococcus multilocularis musashi 0.0033 0.0181 0.0177
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0057 0.0473 0.0598
Echinococcus granulosus cpg binding protein 0.0031 0.0167 0.0167
Schistosoma mansoni ran 0.0044 0.0319 0.0322
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0026 0.0103 0.0101
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0175 0.0175
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0491 0.48
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0319 0.0314
Brugia malayi hypothetical protein 0.0036 0.0221 0.0307
Loa Loa (eye worm) hypothetical protein 0.0043 0.0301 0.0404
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0175 0.0088
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0212 0.0883
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0026 0.0103 0.0101
Schistosoma mansoni hypothetical protein 0.0361 0.4105 0.4203
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0319 0.0428
Schistosoma mansoni lamin 0.0033 0.0181 0.0181
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0026 0.0103 0.0143
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0175 0.0175
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0554 0.0563
Echinococcus granulosus histone lysine methyltransferase setb 0.0107 0.1073 0.1096
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0175 0.0175
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0175 0.0243
Trichomonas vaginalis set domain proteins, putative 0.0705 0.8223 1
Schistosoma mansoni intermediate filament proteins 0.0033 0.0181 0.0181
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0175 0.0175
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0026 0.0103 0.0101
Loa Loa (eye worm) RNA binding protein 0.0064 0.0554 0.0744
Schistosoma mansoni jumonji/arid domain-containing protein 0.0046 0.0344 0.0348
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0032 0.0175 0.0235
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0488 0.0495
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0026 0.0103 0.0101
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0488 0.0474
Loa Loa (eye worm) hypothetical protein 0.0032 0.0175 0.0235
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0488 0.0898
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0607 0.7051 0.7223
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0247 0.2752 0.2816
Schistosoma mansoni peptidase Clp (S14 family) 0.0087 0.0832 0.0848
Trichomonas vaginalis importin beta-1, putative 0.0049 0.0372 0.0332
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0212 0.0286
Brugia malayi MH2 domain containing protein 0.0244 0.2707 0.3759
Loa Loa (eye worm) hypothetical protein 0.006 0.0508 0.0683
Brugia malayi beta-lactamase family protein 0.0039 0.0254 0.0353
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0338 0.0342
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0175 0.0175
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0026 0.0103 0.0099
Brugia malayi steroid hormone receptor 0.0032 0.0175 0.0243
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0026 0.0103 0.0101
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.1503 0.3959
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0319 0.0322
Echinococcus granulosus lamin dm0 0.0033 0.0181 0.0181
Brugia malayi RNA, U transporter 1 0.017 0.1829 0.254
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0049 0.0066
Schistosoma mansoni hypothetical protein 0.0361 0.4105 0.4203
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0175 0.0235
Schistosoma mansoni jumonji/arid domain-containing protein 0.0046 0.0344 0.0348
Schistosoma mansoni lamin 0.0033 0.0181 0.0181
Echinococcus multilocularis geminin 0.0361 0.4105 0.4103
Brugia malayi jmjC domain containing protein 0.0046 0.0344 0.0478
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0175 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0175 0.0243
Schistosoma mansoni coup transcription factor 0.0032 0.0175 0.0175
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0254 0.0186
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0175 0.0171
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.009 0.0088
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0057 0.0473 0.0859
Loa Loa (eye worm) hypothetical protein 0.0035 0.0212 0.0286
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0471 0.5429 0.7539
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0087 0.0832 0.9598
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0012 0.0016
Echinococcus multilocularis expressed protein 0.0026 0.0103 0.0099
Echinococcus granulosus peregrin 0.0038 0.0242 0.0244
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0026 0.0103 0.0099
Echinococcus multilocularis zinc finger protein 0.0022 0.0055 0.0051
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0175 0.0175
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0175 0.0175
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0026 0.0103 0.0143
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0087 0.0832 0.1577
Echinococcus granulosus peptidase Clp S14 family 0.0057 0.0473 0.048
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0107 0.1073 0.1096
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0175 0.0243
Brugia malayi TAR-binding protein 0.0064 0.0554 0.0769
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0554 0.0769
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.1503 0.3959
Schistosoma mansoni hypothetical protein 0.0035 0.0212 0.0213
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0087 0.0832 0.5
Brugia malayi PHD-finger family protein 0.0035 0.0212 0.0295
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0302 0.3407 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.1177 0.2521
Brugia malayi Bromodomain containing protein 0.004 0.027 0.0375
Echinococcus multilocularis lamin 0.0033 0.0181 0.0177
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0488 0.0637
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0488 0.074
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0026 0.0103 0.0143
Entamoeba histolytica hypothetical protein 0.0185 0.1999 1
Brugia malayi Importin beta-1 subunit 0.006 0.0508 0.0705
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.0557 0.0552
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0026 0.0103 0.0101
Plasmodium falciparum phd finger protein, putative 0.0035 0.0212 0.0167
Echinococcus granulosus tar DNA binding protein 0.0064 0.0554 0.0563
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.009 0.0086
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.03 0.0144
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0345 0.3914 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0175 0.0171
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0089 0.086 0.0877
Brugia malayi Latrophilin receptor protein 2 0.0149 0.1575 0.2187
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0026 0.0103 0.0099
Trichomonas vaginalis ran, putative 0.0044 0.0319 0.0265
Loa Loa (eye worm) hypothetical protein 0.0039 0.0254 0.0342
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0026 0.0103 0.0101
Brugia malayi Ets-domain containing protein 0.0071 0.0635 0.0882
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0488 0.0898
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0254 0.0186
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0372 0.0332
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.0457 0.0817
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0026 0.0103 0.0101
Brugia malayi hypothetical protein 0.0535 0.619 0.8597
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0607 0.7051 0.7223
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.0457 0.0817
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0087 0.0832 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0175 0.0243
Loa Loa (eye worm) hypothetical protein 0.0026 0.0103 0.0139
Loa Loa (eye worm) hypothetical protein 0.0039 0.0254 0.0342
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0089 0.086 1
Schistosoma mansoni ap endonuclease 0.0058 0.0488 0.0495
Treponema pallidum hypothetical protein 0.0345 0.3914 1
Leishmania major mitochondrial DNA polymerase beta 0.0302 0.3407 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.1171 0.1195
Loa Loa (eye worm) hypothetical protein 0.004 0.0271 0.0364
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0471 0.5429 0.7295
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0212 0.0213
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0026 0.0103 0.0143
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.1038 0.2141
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0175 0.0243
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0607 0.7051 0.705
Schistosoma mansoni GTP-binding protein alpha subunit 0.0026 0.0103 0.0101
Echinococcus granulosus microtubule associated protein 2 0.0833 0.9761 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0319 0.0204
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0087 0.0832 0.0828
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0026 0.0103 0.0101
Onchocerca volvulus 0.0705 0.8223 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0212 0.0213
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0026 0.0103 0.0139

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 10.4 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits from NadD in a Colorimetric assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 23.2 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits from NadD in a Colorimetric assay - Set 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (binding) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 67.4555 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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