Detailed information for compound 1327814

Basic information

Technical information
  • TDR Targets ID: 1327814
  • Name: 3-[2-[(3-cyano-8-methylquinolin-2-yl)amino]et hyl]-1-(3-morpholin-4-ylpropyl)thiourea
  • MW: 412.552 | Formula: C21H28N6OS
  • H donors: 2 H acceptors: 2 LogP: 3.17 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cc2cccc(c2nc1NCCN=C(NCCCN1CCOCC1)S)C
  • InChi: 1S/C21H28N6OS/c1-16-4-2-5-17-14-18(15-22)20(26-19(16)17)23-7-8-25-21(29)24-6-3-9-27-10-12-28-13-11-27/h2,4-5,14H,3,6-13H2,1H3,(H,23,26)(H2,24,25,29)
  • InChiKey: MMDYELLRHZIODZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[2-[(3-cyano-8-methyl-2-quinolyl)amino]ethyl]-1-(3-morpholinopropyl)thiourea
  • 3-[2-[(3-cyano-8-methyl-quinolin-2-yl)amino]ethyl]-1-(3-morpholin-4-ylpropyl)thiourea
  • MLS000556817
  • SMR000173451
  • ASN 06537870
  • 1-[2-(3-Cyano-8-methyl-quinolin-2-ylamino)-ethyl]-3-(3-morpholin-4-yl-propyl)-thiourea

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tubulin alpha 3 chain 0.0182 0.7516 0.7516
Plasmodium vivax tubulin epsilon chain, putative 0.0135 0.5329 0.5329
Brugia malayi tubulin alpha chain - mouse 0.0182 0.7516 0.7516
Brugia malayi Tubulin alpha-2 chain 0.0182 0.7516 0.7516
Echinococcus multilocularis Tubulin beta 2C chain 0.0237 1 1
Trypanosoma brucei beta tubulin 0.0237 1 1
Schistosoma mansoni alpha tubulin 0.0182 0.7516 0.7516
Trichomonas vaginalis tubulin alpha chain, putative 0.0076 0.2654 0.2654
Leishmania major hypothetical protein, conserved 0.0019 0.0035 0.0035
Trichomonas vaginalis tubulin gamma chain, putative 0.0237 1 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.1167 0.1167
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0283 0.0283
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0124 0.4841 0.4841
Brugia malayi jmjC domain containing protein 0.0071 0.2421 0.2421
Trichomonas vaginalis tubulin alpha chain, putative 0.0135 0.5329 0.5329
Loa Loa (eye worm) hypothetical protein 0.0148 0.5943 0.5943
Giardia lamblia Alpha-tubulin 0.0182 0.7516 0.7516
Leishmania major beta tubulin 0.0237 1 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.8178 0.8178
Trichomonas vaginalis tubulin beta chain, putative 0.0076 0.2654 0.2654
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0035 0.0035
Leishmania major beta tubulin 0.0237 1 1
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0283 0.0283
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.1268 0.1268
Leishmania major hypothetical protein, conserved 0.0024 0.0283 0.0283
Trypanosoma brucei zeta tubulin, putative 0.0058 0.1843 0.1843
Leishmania major alpha tubulin 0.0182 0.7516 0.7516
Trypanosoma cruzi zeta tubulin, putative 0.0058 0.1843 0.1843
Echinococcus multilocularis tubulin alpha 1C chain 0.0182 0.7516 0.7516
Brugia malayi alpha-tubulin 0.0182 0.7516 0.7516
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0035 0.0035
Schistosoma mansoni alpha-glucosidase 0.0169 0.6923 0.6923
Trichomonas vaginalis tubulin beta chain, putative 0.0182 0.7516 0.7516
Schistosoma mansoni jumonji domain containing protein 0.0071 0.2421 0.2421
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.1843 0.1843
Trichomonas vaginalis tubulin alpha chain, putative 0.0076 0.2654 0.2654
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0076 0.2654 0.2654
Mycobacterium ulcerans cell division protein FtsZ 0.0058 0.1843 0.7296
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.0164 0.6665 0.6665
Loa Loa (eye worm) alpha-tubulin 0.0182 0.7516 0.7516
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0283 0.0283
Brugia malayi Tubulin alpha chain 0.0182 0.7516 0.7516
Leishmania major beta tubulin 0.0237 1 1
Loa Loa (eye worm) tubulin beta-2A chain 0.0237 1 1
Echinococcus granulosus Tubulin beta 2C chain 0.0237 1 1
Echinococcus granulosus tubulin alpha chain 0.0182 0.7516 0.7516
Trypanosoma brucei beta tubulin 0.0237 1 1
Plasmodium falciparum alpha tubulin 2 0.0182 0.7516 0.7516
Loa Loa (eye worm) tubulin beta chain 0.0237 1 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0035 0.0035
Plasmodium falciparum tubulin gamma chain 0.0135 0.5329 0.5329
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0058 0.1843 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0042 0.0042
Echinococcus multilocularis Tubulin alpha 1 chain 0.0182 0.7516 0.7516
Leishmania major alpha tubulin 0.0182 0.7516 0.7516
Giardia lamblia Delta tubulin 0.0058 0.1843 0.1843
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.3662 0.3662
Entamoeba histolytica tubulin gamma chain 0.0135 0.5329 0.5329
Echinococcus granulosus tubulin alpha 0.0135 0.5329 0.5329
Brugia malayi beta-tubulin, identical 0.0237 1 1
Trypanosoma cruzi tubulin delta chain 0.0058 0.1843 0.1843
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.1167 0.1167
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0042 0.0165
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.3662 0.3662
Trypanosoma cruzi tubulin delta chain 0.0058 0.1843 0.1843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1268 0.1268
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.2421 0.2421
Leishmania major beta tubulin 0.0237 1 1
Plasmodium vivax JmjC domain containing protein 0.0019 0.0035 0.0035
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.8178 0.8178
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.2526 0.2526
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0035 0.0035
Echinococcus granulosus tubulin alpha chain 0.0182 0.7516 0.7516
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.2421 0.2421
Loa Loa (eye worm) hypothetical protein 0.0098 0.3662 0.3662
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0035 0.0035
Leishmania major alpha tubulin 0.0182 0.7516 0.7516
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1268 0.1268
Leishmania major alpha tubulin 0.0182 0.7516 0.7516
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0042 0.0042
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.8178 0.8178
Plasmodium vivax tubulin alpha chain, putative 0.0182 0.7516 0.7516
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.445 0.445
Schistosoma mansoni tubulin subunit beta 0.0237 1 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0058 0.1843 0.1843
Echinococcus granulosus tubulin alpha 1C chain 0.0182 0.7516 0.7516
Trypanosoma brucei beta tubulin 0.0237 1 1
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0237 1 1
Loa Loa (eye worm) tubulin beta chain 0.0058 0.1843 0.1843
Toxoplasma gondii beta-tubulin, putative 0.0237 1 1
Trypanosoma cruzi epsilon tubulin, putative 0.0135 0.5329 0.5329
Echinococcus granulosus Tubulin beta 2C chain 0.0237 1 1
Loa Loa (eye worm) BEN-1 protein 0.0237 1 1
Trypanosoma brucei epsilon tubulin 0.0135 0.5329 0.5329
Echinococcus granulosus tubulin alpha 1C chain 0.0182 0.7516 0.7516
Plasmodium falciparum tubulin beta chain 0.0237 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.1167 0.1167
Brugia malayi Tubulin alpha chain 0.0058 0.1843 0.1843
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0042 0.0042
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.2526 1
Echinococcus multilocularis peroxisome assembly protein 26 0.0182 0.7516 0.7516
Brugia malayi Tubulin beta chain 0.0076 0.2654 0.2654
Echinococcus multilocularis tubulin gamma 1 chain 0.0135 0.5329 0.5329
Schistosoma mansoni tubulin subunit beta 0.0237 1 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.4841 0.4841
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.2421 0.2421
Trypanosoma brucei beta tubulin 0.0237 1 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Echinococcus granulosus tubulin subunit TubB 0.0182 0.7516 0.7516
Schistosoma mansoni hypothetical protein 0.0164 0.6665 0.6665
Brugia malayi jmjC domain containing protein 0.0019 0.0035 0.0035
Trichomonas vaginalis tubulin, putative 0.0237 1 1
Loa Loa (eye worm) tubulin alpha-2 chain 0.0182 0.7516 0.7516
Trichomonas vaginalis tubulin beta chain, putative 0.0237 1 1
Schistosoma mansoni tubulin subunit alpha 0.0182 0.7516 0.7516
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.059 0.059
Brugia malayi hypothetical protein 0.0024 0.0283 0.0283
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0106 0.403 0.403
Schistosoma mansoni hypothetical protein 0.0031 0.059 0.059
Echinococcus granulosus Tubulin beta 2C chain 0.0237 1 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0035 0.0035
Schistosoma mansoni alpha tubulin 0.0182 0.7516 0.7516
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.8178 0.8178
Schistosoma mansoni hypothetical protein 0.0031 0.059 0.059
Echinococcus granulosus Tubulin beta 2C chain 0.0237 1 1
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0035 0.0035
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1268 0.1268
Echinococcus multilocularis tubulin alpha chain 0.0182 0.7516 0.7516
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1268 0.1268
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.059 0.059
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.2526 1
Loa Loa (eye worm) beta-tubulin 0.0237 1 1
Leishmania major alpha tubulin 0.0182 0.7516 0.7516
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.2421 0.2421
Leishmania major beta tubulin 0.0237 1 1
Brugia malayi isocitrate dehydrogenase 0.0019 0.0042 0.0042
Loa Loa (eye worm) alpha-tubulin 0.0182 0.7516 0.7516
Echinococcus granulosus tubulin beta 1 chain 0.0237 1 1
Trypanosoma brucei alpha tubulin 0.0182 0.7516 0.7516
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.2526 0.2526
Echinococcus multilocularis beta tubulin 0.0237 1 1
Trypanosoma brucei beta tubulin 0.0135 0.5329 0.5329
Trypanosoma brucei alpha tubulin 0.0182 0.7516 0.7516
Plasmodium vivax tubulin beta chain, putative 0.0237 1 1
Echinococcus granulosus tubulin alpha 3 chain 0.0182 0.7516 0.7516
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.1167 0.1167
Echinococcus multilocularis GPCR, family 2 0.0031 0.059 0.059
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.1167 0.1167
Trypanosoma brucei tubulin delta chain 0.0058 0.1843 0.1843
Loa Loa (eye worm) tubulin alpha chain 0.0182 0.7516 0.7516
Echinococcus granulosus beta tubulin 0.0237 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.2526 0.2526
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0283 0.0283
Brugia malayi jmjC domain containing protein 0.0019 0.0035 0.0035
Trypanosoma brucei epsilon tubulin 0.0135 0.5329 0.5329
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.059 0.059
Brugia malayi hypothetical protein 0.0148 0.5943 0.5943
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.2421 0.2421
Echinococcus granulosus tubulin epsilon chain 0.0135 0.5329 0.5329
Leishmania major beta tubulin 0.0237 1 1
Trypanosoma brucei alpha tubulin, putative 0.0076 0.2654 0.2654
Leishmania major alpha tubulin 0.0182 0.7516 0.7516
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.224 0.224
Echinococcus multilocularis tubulin alpha 1C chain 0.0182 0.7516 0.7516
Loa Loa (eye worm) tubulin alpha 2 0.0048 0.1355 0.1355
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Echinococcus multilocularis tubulin alpha chain 0.0182 0.7516 0.7516
Leishmania major beta tubulin 0.0237 1 1
Leishmania major beta tubulin 0.0237 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0182 0.7516 0.7516
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.445 0.445
Leishmania major zeta tubulin, putative 0.0058 0.1843 0.1843
Entamoeba histolytica tubulin family protein 0.0237 1 1
Trypanosoma cruzi beta tubulin, putative 0.0237 1 1
Leishmania major delta tubulin, putative 0.0058 0.1843 0.1843
Echinococcus multilocularis tubulin subunit beta 0.0237 1 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0182 0.7516 0.7516
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0283 0.0283
Leishmania major beta tubulin 0.0237 1 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0058 0.1843 0.1843
Onchocerca volvulus Huntingtin homolog 0.0148 0.5943 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.2526 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0237 1 1
Echinococcus granulosus alpha tubulin 0.0182 0.7516 0.7516
Schistosoma mansoni tubulin subunit alpha 0.0182 0.7516 0.7516
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0124 0.4841 0.4841
Echinococcus multilocularis Tubulin beta 2C chain 0.0237 1 1
Trichomonas vaginalis tubulin, putative 0.0058 0.1843 0.1843
Echinococcus multilocularis tubulin epsilon chain 0.0135 0.5329 0.5329
Trichomonas vaginalis tubulin epsilon chain, putative 0.0182 0.7516 0.7516
Schistosoma mansoni tubulin subunit beta 0.0237 1 1
Echinococcus granulosus geminin 0.0164 0.6665 0.6665
Trypanosoma brucei zeta tubulin 0.0058 0.1843 0.1843
Loa Loa (eye worm) BEN-1 protein 0.0237 1 1
Onchocerca volvulus 0.0114 0.4379 0.5245
Toxoplasma gondii alpha-tubulin I, putative 0.0182 0.7516 0.7516
Echinococcus multilocularis tubulin alpha 0.0135 0.5329 0.5329
Echinococcus granulosus tubulin alpha 3 chain 0.0182 0.7516 0.7516
Loa Loa (eye worm) hypothetical protein 0.0031 0.059 0.059
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0042 0.0042
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.2526 0.2526
Echinococcus granulosus beta tubulin 0.0237 1 1
Trichomonas vaginalis tubulin, putative 0.0076 0.2654 0.2654
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.2526 0.2526
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.1167 0.1167
Trypanosoma brucei alpha tubulin 0.0182 0.7516 0.7516
Mycobacterium leprae cell division protein FtsZ 0.0058 0.1843 0.5
Entamoeba histolytica tubulin alpha chain, putative 0.0182 0.7516 0.7516
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0035 0.0035
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.8178 0.8178
Brugia malayi MH2 domain containing protein 0.0115 0.445 0.445
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1268 0.1268
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.0035
Echinococcus granulosus tubulin subunit beta 0.0237 1 1
Schistosoma mansoni tubulin subunit alpha 0.0058 0.1843 0.1843
Trichomonas vaginalis tubulin beta chain, putative 0.0182 0.7516 0.7516
Schistosoma mansoni hypothetical protein 0.0031 0.059 0.059
Trichomonas vaginalis tubulin gamma chain, putative 0.0135 0.5329 0.5329
Leishmania major beta tubulin 0.0237 1 1
Schistosoma mansoni tubulin subunit epsilon 0.0135 0.5329 0.5329
Trypanosoma cruzi alpha tubulin, putative 0.0182 0.7516 0.7516
Schistosoma mansoni tubulin subunit alpha 0.0182 0.7516 0.7516
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.1167 0.1167
Leishmania major alpha tubulin 0.0182 0.7516 0.7516
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.1167 0.1167
Toxoplasma gondii alpha tubulin TUBA1 0.0182 0.7516 0.7516
Echinococcus granulosus Tubulin alpha 1 chain 0.0182 0.7516 0.7516
Brugia malayi Tubulin beta chain 0.0058 0.1843 0.1843
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.1268 0.1268
Echinococcus multilocularis geminin 0.0164 0.6665 0.6665
Trichomonas vaginalis tubulin beta chain, putative 0.0182 0.7516 0.7516
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.1167 0.1167
Schistosoma mansoni alpha-glucosidase 0.0169 0.6923 0.6923
Plasmodium vivax delta tubulin, putative 0.0058 0.1843 0.1843
Loa Loa (eye worm) tubulin beta-4 chain 0.0237 1 1
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0035 0.0035
Schistosoma mansoni tubulin subunit beta 0.0237 1 1
Leishmania major alpha tubulin 0.0182 0.7516 0.7516
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0106 0.403 0.403
Leishmania major alpha tubulin 0.0182 0.7516 0.7516
Trypanosoma cruzi tubulin gamma chain 0.0135 0.5329 0.5329
Trypanosoma cruzi zeta tubulin, putative 0.0058 0.1843 0.1843
Trichomonas vaginalis tubulin, putative 0.0076 0.2654 0.2654
Loa Loa (eye worm) tubulin alpha 2 0.0124 0.4841 0.4841
Giardia lamblia Beta tubulin 0.0237 1 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0058 0.1843 0.1843
Trypanosoma brucei alpha tubulin 0.0182 0.7516 0.7516
Echinococcus multilocularis Tubulin beta 2C chain 0.0237 1 1
Leishmania major beta tubulin 0.0237 1 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.1167 0.1167
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.1167 0.1167
Echinococcus multilocularis hypothetical protein 0.0182 0.7516 0.7516
Giardia lamblia Gamma tubulin 0.0135 0.5329 0.5329
Entamoeba histolytica tubulin family protein 0.0237 1 1
Echinococcus granulosus tubulin beta 4A class IVa 0.0237 1 1
Echinococcus granulosus tubulin delta chain 0.0058 0.1843 0.1843
Toxoplasma gondii beta-1 tubulin, putative 0.0237 1 1
Schistosoma mansoni alpha tubulin 0.0182 0.7516 0.7516
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.1167 0.1167
Echinococcus granulosus peroxisome assembly protein 26 0.0182 0.7516 0.7516
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0035 0.0035
Echinococcus granulosus Tubulin beta 2C chain 0.0237 1 1
Plasmodium vivax tubulin gamma chain, putative 0.0135 0.5329 0.5329
Leishmania major beta tubulin 0.0237 1 1
Schistosoma mansoni tubulin subunit beta 0.0237 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.3662 0.3662
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.1167 0.1167
Echinococcus multilocularis tubulin alpha 3 chain 0.0182 0.7516 0.7516
Loa Loa (eye worm) hypothetical protein 0.0182 0.7516 0.7516
Brugia malayi jmjC domain containing protein 0.0071 0.2421 0.2421
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0042 0.0042
Brugia malayi jmjC domain containing protein 0.0019 0.0035 0.0035
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0135 0.5329 0.5329
Trypanosoma brucei tubulin gamma chain 0.0135 0.5329 0.5329
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0035 0.0035
Echinococcus granulosus tubulin alpha chain 0.0182 0.7516 0.7516
Mycobacterium tuberculosis Cell division protein FtsZ 0.0058 0.1843 0.7296
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.059 0.059
Leishmania major beta tubulin 0.0237 1 1
Giardia lamblia Beta tubulin 0.0237 1 1
Schistosoma mansoni tubulin subunit beta 0.0237 1 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.5943 0.5943
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1268 0.1268
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.2526 0.2526
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0035 0.0035
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0042 0.0042
Brugia malayi Tubulin gamma chain 0.0135 0.5329 0.5329
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.1167 0.1167
Trichomonas vaginalis tubulin alpha chain, putative 0.0237 1 1
Leishmania major alpha tubulin 0.0182 0.7516 0.7516
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0035 0.0035
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.2421 0.2421
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.059 0.059
Giardia lamblia Beta tubulin 0.0237 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.2526 1
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0035 0.0035
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0058 0.1843 0.1843
Plasmodium falciparum alpha tubulin 1 0.0182 0.7516 0.7516
Plasmodium falciparum tubulin epsilon chain, putative 0.0135 0.5329 0.5329
Echinococcus granulosus phd:f box containing protein 0.0019 0.0035 0.0035
Entamoeba histolytica tubulin alpha-1 chain 0.0182 0.7516 0.7516
Brugia malayi Tubulin alpha-2 chain 0.0182 0.7516 0.7516
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.1167 0.1167
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0042 0.0042
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0042 0.0042
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0035 0.0035
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.1167 0.1167
Echinococcus granulosus tubulin alpha chain 0.0182 0.7516 0.7516
Giardia lamblia Alpha-tubulin 0.0182 0.7516 0.7516
Leishmania major beta tubulin 0.0237 1 1
Leishmania major gamma-tubulin 0.0135 0.5329 0.5329
Echinococcus multilocularis Tubulin alpha 1 chain 0.0182 0.7516 0.7516
Leishmania major beta tubulin 0.0237 1 1
Echinococcus granulosus GPCR family 2 0.0031 0.059 0.059
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.1167 0.1167
Echinococcus multilocularis Tubulin beta 2C chain 0.0237 1 1
Echinococcus multilocularis tubulin delta chain 0.0058 0.1843 0.1843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1268 0.1268
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0058 0.1843 0.1843
Schistosoma mansoni tubulin subunit gamma 0.0135 0.5329 0.5329
Brugia malayi Cell division protein ftsZ 0.0058 0.1843 0.1843
Trypanosoma cruzi epsilon tubulin, putative 0.0135 0.5329 0.5329
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.1843 0.1843
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.1167 0.1167
Schistosoma mansoni tubulin subunit delta 0.0058 0.1843 0.1843
Trypanosoma brucei epsilon tubulin 0.0135 0.5329 0.5329
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0042 0.0042
Schistosoma mansoni hypothetical protein 0.0067 0.224 0.224
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.1167 0.1167
Loa Loa (eye worm) tubulin beta-1 chain 0.0237 1 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.224 0.224
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0042 0.0042
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0035 0.0035
Leishmania major beta tubulin 0.0237 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0283 0.0283
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0035 0.0035
Brugia malayi Latrophilin receptor protein 2 0.0031 0.059 0.059
Trichomonas vaginalis tubulin beta chain, putative 0.0182 0.7516 0.7516
Echinococcus granulosus Tubulin alpha 1 chain 0.0182 0.7516 0.7516
Loa Loa (eye worm) hypothetical protein 0.0024 0.0283 0.0283
Trichomonas vaginalis tubulin epsilon chain, putative 0.0237 1 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.2421 0.2421
Treponema pallidum cell division protein FtsZ 0.0058 0.1843 1
Echinococcus multilocularis tubulin subunit TubB 0.0182 0.7516 0.7516
Echinococcus granulosus tubulin alpha chain 0.0182 0.7516 0.7516
Leishmania major beta tubulin 0.0237 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0035 0.0035
Echinococcus multilocularis beta tubulin 0.0237 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0182 0.7516 0.7516
Trichomonas vaginalis tubulin epsilon chain, putative 0.0237 1 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0042 0.0042
Trypanosoma brucei glucosidase, putative 0.0044 0.1167 0.1167
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0042 0.0042
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0042 0.0042
Toxoplasma gondii beta tubulin 0.0237 1 1
Schistosoma mansoni hypothetical protein 0.0031 0.059 0.059
Loa Loa (eye worm) tubulin alpha-3 chain 0.0106 0.403 0.403
Brugia malayi tubulin alpha-2 chain 0.0182 0.7516 0.7516
Plasmodium falciparum tubulin delta chain, putative 0.0058 0.1843 0.1843
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0035 0.0035
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0042 0.0042
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0035 0.0035
Loa Loa (eye worm) tubulin alpha chain 0.0182 0.7516 0.7516
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0042 0.0042
Echinococcus multilocularis tubulin alpha chain 0.0182 0.7516 0.7516
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0042 0.0042
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0283 0.0283
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0182 0.7516 0.7516
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0042 0.0042
Loa Loa (eye worm) tubulin alpha 2 0.0124 0.4841 0.4841
Echinococcus multilocularis tubulin beta 1 chain 0.0237 1 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.059 0.059
Giardia lamblia Epsilon tubulin 0.0058 0.1843 0.1843
Trichomonas vaginalis tubulin epsilon chain, putative 0.0182 0.7516 0.7516
Onchocerca volvulus Huntingtin homolog 0.0148 0.5943 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0182 0.7516 0.7516
Leishmania major alpha tubulin 0.0182 0.7516 0.7516
Loa Loa (eye worm) tubulin gamma chain 0.0135 0.5329 0.5329
Brugia malayi jmjC domain containing protein 0.0019 0.0035 0.0035
Leishmania major epsilon tubulin, putative 0.0135 0.5329 0.5329
Trichomonas vaginalis tubulin gamma chain, putative 0.0135 0.5329 0.5329
Schistosoma mansoni tubulin subunit beta 0.0058 0.1843 0.1843
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0035 0.0035
Schistosoma mansoni alpha glucosidase 0.0044 0.1167 0.1167
Echinococcus granulosus tubulin gamma 1 chain 0.0135 0.5329 0.5329
Leishmania major beta tubulin 0.0237 1 1
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0035 0.0035
Echinococcus multilocularis tubulin alpha chain 0.0182 0.7516 0.7516
Echinococcus multilocularis tubulin alpha chain 0.0182 0.7516 0.7516
Trichomonas vaginalis tubulin alpha chain, putative 0.0076 0.2654 0.2654
Plasmodium vivax tubulin alpha chain, putative 0.0182 0.7516 0.7516
Leishmania major alpha tubulin 0.0182 0.7516 0.7516

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.5012 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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