Detailed information for compound 1328028

Basic information

Technical information
  • TDR Targets ID: 1328028
  • Name: 5-[4-(4-chlorophenyl)piperazin-1-yl]-2H-1,2,4 -triazol-3-amine
  • MW: 278.741 | Formula: C12H15ClN6
  • H donors: 2 H acceptors: 2 LogP: 2.32 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)N1CCN(CC1)c1[nH]nc(n1)N
  • InChi: 1S/C12H15ClN6/c13-9-1-3-10(4-2-9)18-5-7-19(8-6-18)12-15-11(14)16-17-12/h1-4H,5-8H2,(H3,14,15,16,17)
  • InChiKey: IZOPTJPBJXSUFQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-[4-(4-chlorophenyl)-1-piperazinyl]-2H-1,2,4-triazol-3-amine
  • [5-[4-(4-chlorophenyl)piperazin-1-yl]-2H-1,2,4-triazol-3-yl]amine
  • ZINC01399925
  • Oprea1_475982
  • 5-[4-(4-chlorophenyl)piperazino]-1H-1,2,4-triazol-3-amine
  • MLS000694836
  • SMR000333140
  • 8C-107

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens growth factor, augmenter of liver regeneration Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR Get druggable targets OG5_127535 All targets in OG5_127535
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma congolense ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Neospora caninum hypothetical protein Get druggable targets OG5_127535 All targets in OG5_127535
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) hepatopoietin HPO2 Get druggable targets OG5_127535 All targets in OG5_127535
Schistosoma japonicum FAD-linked sulfhydryl oxidase ALR, putative Get druggable targets OG5_127535 All targets in OG5_127535
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans similar to S. cerevisiae ERV2 (YPR037C) endoplasmic reticulum flavin-linked sulfhydryl oxidase Get druggable targets OG5_127535 All targets in OG5_127535
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Brugia malayi Augmenter of liver regeneration Get druggable targets OG5_127535 All targets in OG5_127535
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Babesia bovis human hepatopoietin-like protein, putative Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania donovani ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Toxoplasma gondii Erv1 / Alr family protein Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium berghei FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Theileria parva hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Toxoplasma gondii Erv1 / Alr family protein Get druggable targets OG5_127535 All targets in OG5_127535
Candida albicans hypothetical protein Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127535 All targets in OG5_127535
Candida albicans similar to S. cerevisiae ERV2 (YPR037C) endoplasmic reticulum flavin-linked sulfhydryl oxidase Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania major hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma congolense ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR Get druggable targets OG5_127535 All targets in OG5_127535
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium knowlesi FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.1575 0.1733
Trypanosoma brucei glucosidase, putative 0.0044 0.0367 0.0731
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.003 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0074
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0367 0.0731
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0022 0.0095 0.0343
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.2547 0.5472
Echinococcus granulosus microtubule associated protein 2 0.0729 0.8815 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0226 0.0368
Echinococcus granulosus importin subunit beta 1 0.0028 0.0173 0.0132
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.1575 0.1527
Echinococcus granulosus cpg binding protein 0.0031 0.0217 0.0183
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0058 0.0001
Brugia malayi Importin beta-1 subunit 0.0028 0.0173 0.0372
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0189 0.0373
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0367 0.0758
Brugia malayi chromobox protein homolog 3 0.0041 0.0338 0.0727
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0376 0.0777
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0114 0.0188
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0391 0.4649 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0308 0.0646
Echinococcus granulosus dnaJ subfamily B 0.0424 0.5059 0.5711
Loa Loa (eye worm) hypothetical protein 0.0023 0.0114 0.0228
Brugia malayi intermediate filament protein 0.0027 0.0163 0.035
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0057 0.00000735
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.1173 0.2496
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0322 0.0692
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0074
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0391 0.4649 0.5243
Leishmania major DNA polymerase kappa, putative 0.0019 0.0064 0.0074
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0163 0.0334
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0077 0.0783 0.163
Mycobacterium tuberculosis Probable lipase LipD 0.0109 0.1173 0.1335
Onchocerca volvulus 0.0262 0.3057 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0226 0.0193
Mycobacterium tuberculosis Probable esterase LipL 0.0109 0.1173 0.1335
Mycobacterium tuberculosis Probable hydrolase 0.0109 0.1173 0.1335
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0391 0.4649 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0207 0.0171
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0022 0.0095 0.0046
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0367 0.0758
Echinococcus multilocularis geminin 0.017 0.1925 0.1878
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0022 0.0013
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.2254 0.4848
Loa Loa (eye worm) hypothetical protein 0.0052 0.0473 0.1003
Echinococcus granulosus lamin 0.0027 0.0163 0.0121
Trypanosoma brucei cytochrome P450, putative 0.0028 0.0174 0.0314
Schistosoma mansoni alpha-glucosidase 0.0169 0.1916 0.2123
Echinococcus multilocularis disco interacting protein 2 0.0023 0.0114 0.0057
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0023 0.0114 0.0068
Schistosoma mansoni jumonji domain containing protein 0.008 0.0813 0.0863
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0109 0.1173 0.1335
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0058 0.0061
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.1173 0.2475
Loa Loa (eye worm) hypothetical protein 0.0023 0.0114 0.0228
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0338 0.0694
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0374 0.0362
Echinococcus granulosus lamin dm0 0.0027 0.0163 0.0121
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0064 0.0074
Brugia malayi Augmenter of liver regeneration 0.0041 0.034 0.0731
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0189 0.0373
Brugia malayi beta-lactamase family protein 0.0109 0.1173 0.2523
Mycobacterium leprae Probable lipase LipE 0.0109 0.1173 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0058 0.0108
Leishmania major cytochrome p450-like protein 0.0018 0.0057 0.006
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.003 0.0029
Brugia malayi PHD-finger family protein 0.0031 0.0207 0.0446
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0114 0.0188
Mycobacterium ulcerans putative fatty-acid--CoA ligase 0.0023 0.0114 0.0188
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.35 0.7526
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0367 0.079
Echinococcus multilocularis microtubule associated protein 2 0.0729 0.8815 0.8808
Onchocerca volvulus 0.003 0.0196 0.0551
Echinococcus granulosus peregrin 0.0031 0.0207 0.0171
Schistosoma mansoni hypothetical protein 0.017 0.1925 0.2132
Schistosoma mansoni ran 0.0021 0.0082 0.0029
Loa Loa (eye worm) hypothetical protein 0.0031 0.0207 0.043
Onchocerca volvulus 0.0251 0.2922 0.9553
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0082 0.0025
Loa Loa (eye worm) hypothetical protein 0.0262 0.3057 0.657
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0207 0.0327
Schistosoma mansoni hypothetical protein 0.004 0.0322 0.0302
Echinococcus multilocularis GPCR, family 2 0.0019 0.0057 0.0000064738
Loa Loa (eye worm) hypothetical protein 0.0028 0.0173 0.0356
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0041 0.034 0.0284
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0008 0.0017
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.169 0.3595
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0047
Echinococcus multilocularis snurportin 1 0.0298 0.35 0.3463
Schistosoma mansoni ap endonuclease 0.0019 0.0058 0.0001
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0391 0.4649 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0141 0.0287
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0141 0.0241
Schistosoma mansoni peripheral-type benzodiazepine receptor 0.0262 0.3057 0.3425
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0064 0.0121
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0109 0.1173 0.2523
Schistosoma mansoni chromobox protein 0.0074 0.0736 0.0776
Mycobacterium ulcerans hypothetical protein 0.0109 0.1173 0.3718
Mycobacterium leprae conserved hypothetical protein 0.0109 0.1173 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.1173 0.251
Brugia malayi Cytochrome P450 family protein 0.0018 0.0057 0.0123
Mycobacterium ulcerans hypothetical protein 0.0168 0.1901 0.6145
Schistosoma mansoni hypothetical protein 0.0019 0.0057 0.00000735
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0141 0.0181
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0058 0.5
Toxoplasma gondii exonuclease III APE 0.0019 0.0058 0.0001
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0064 0.0074
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0057 0.006
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0082 0.0053
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0082 0.0114
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0373 0.0803
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0082 0.0177
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.1173 0.1274
Loa Loa (eye worm) hypothetical protein 0.0041 0.0338 0.0711
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0023 0.0114 0.0068
Onchocerca volvulus 0.0262 0.3057 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0074
Trichomonas vaginalis maltase-glucoamylase, putative 0.0016 0.003 0.0029
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.1575 0.3388
Echinococcus granulosus beta LACTamase domain containing family member 0.0109 0.1173 0.1274
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0057 0.0000064738
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0376 0.0777
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0367 0.0758
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.1067 0.1154
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0058 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0074
Trichomonas vaginalis set domain proteins, putative 0.0251 0.2922 0.6272
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0338 0.1018
Loa Loa (eye worm) hypothetical protein 0.0058 0.055 0.1168
Schistosoma mansoni microtubule-associated protein tau 0.0729 0.8815 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0367 0.0675
Onchocerca volvulus 0.0027 0.0163 0.044
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0082 0.0029
Brugia malayi hypothetical protein 0.0035 0.026 0.056
Schistosoma mansoni chromobox protein 0.0074 0.0736 0.0776
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0783 0.163
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0082 0.0114
Loa Loa (eye worm) hypothetical protein 0.0032 0.0226 0.047
Loa Loa (eye worm) hypothetical protein 0.004 0.0322 0.0677
Loa Loa (eye worm) hypothetical protein 0.0109 0.1173 0.251
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.003 0.0029
Brugia malayi jmjC domain containing protein 0.01 0.1067 0.2296
Schistosoma mansoni hypothetical protein 0.0031 0.0207 0.0171
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0391 0.4649 1
Mycobacterium ulcerans beta-lactamase 0.0109 0.1173 0.3718
Leishmania major DNA polymerase eta, putative 0.0031 0.0212 0.0394
Plasmodium vivax SET domain protein, putative 0.0032 0.0226 0.0366
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0367 0.0758
Schistosoma mansoni cpg binding protein 0.003 0.0196 0.0159
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0109 0.1173 0.251
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0207 0.0327
Entamoeba histolytica hypothetical protein 0.0035 0.026 0.05
Schistosoma mansoni alpha glucosidase 0.0044 0.0367 0.0354
Schistosoma mansoni intermediate filament proteins 0.0027 0.0163 0.0121
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0023 0.0114 0.0506
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.003 0.0029
Toxoplasma gondii Erv1 / Alr family protein 0.0041 0.034 0.0615
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0057 0.00000735
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.1067 0.1016
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0077 0.0783 0.163
Leishmania major mitochondrial DNA polymerase beta 0.0319 0.3762 0.808
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0174 0.0359
Loa Loa (eye worm) hypothetical protein 0.0027 0.0163 0.0334
Onchocerca volvulus Alhambra homolog 0.0031 0.0207 0.0587
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0074
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0207 0.043
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0391 0.4649 1
Echinococcus granulosus translocator protein 0.0262 0.3057 0.3425
Leishmania major importin beta-1 subunit, putative 0.0023 0.0108 0.017
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0041 0.034 0.0671
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.1173 0.2496
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0058 0.0001
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0308 0.0286
Brugia malayi hypothetical protein 0.0016 0.003 0.0065
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.003 0.0029
Loa Loa (eye worm) cytochrome P450 0.0018 0.0057 0.0106
Mycobacterium ulcerans esterase/lipase LipP 0.0109 0.1173 0.3718
Echinococcus multilocularis dna polymerase eta 0.0044 0.0373 0.0318
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) 0.0023 0.0114 0.0068
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0061 0.0096
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0367 0.0758
Onchocerca volvulus 0.0052 0.0473 0.1465
Entamoeba histolytica hypothetical protein 0.0035 0.026 0.05
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0391 0.4649 0.5243
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0023 0.0114 0.0068
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0382 0.0763
Mycobacterium tuberculosis Conserved hypothetical protein 0.0168 0.1901 0.2206
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0057 0.006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0226 0.0193
Echinococcus granulosus dna polymerase eta 0.0044 0.0373 0.0361
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0058 0.0061
Loa Loa (eye worm) hepatopoietin HPO2 0.0041 0.034 0.0715
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0041 0.034 0.0614
Loa Loa (eye worm) hypothetical protein 0.0032 0.0228 0.0474
Entamoeba histolytica hypothetical protein 0.0035 0.026 0.05
Brugia malayi hypothetical protein 0.0025 0.0141 0.0303
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0174 0.0359
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.1173 0.2496
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0736 0.1555
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.026 0.0232
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.1575 0.1733
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0783 0.163
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.1575 0.1733
Leishmania major cytochrome p450-like protein 0.0018 0.0057 0.006
Loa Loa (eye worm) hypothetical protein 0.0262 0.3057 0.657
Schistosoma mansoni hypothetical protein 0.0019 0.0057 0.00000735
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0382 0.0763
Loa Loa (eye worm) transcription factor SMAD2 0.014 0.1555 0.3334
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0064 0.0008
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.1173 0.2496
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0391 0.4649 1
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0391 0.4649 1
Brugia malayi beta-lactamase 0.0109 0.1173 0.2523
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0058 0.5
Leishmania major DNA polymerase eta, putative 0.0044 0.0373 0.0745
Schistosoma mansoni DNA polymerase eta 0.0044 0.0373 0.0361
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.1173 0.2496
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0064 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0074
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0141 0.0182
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0391 0.4649 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0109 0.1173 0.1122
Onchocerca volvulus 0.0262 0.3057 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0058 0.0124
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0077 0.0783 0.163
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0082 0.0055
Trichomonas vaginalis ran, putative 0.0021 0.0082 0.0143
Schistosoma mansoni ran 0.0021 0.0082 0.0029
Brugia malayi TspO/MBR family protein 0.0262 0.3057 0.6576
Entamoeba histolytica hypothetical protein 0.0035 0.026 0.05
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0173 0.0311
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0041 0.034 0.0323
Plasmodium falciparum importin beta, putative 0.0028 0.0173 0.0251
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0367 0.0758
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0163 0.035
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0367 0.0758
Onchocerca volvulus 0.0109 0.1173 0.3776
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0367 0.0354
Loa Loa (eye worm) hypothetical protein 0.0262 0.3057 0.657
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.1575 0.1733
Mycobacterium tuberculosis Conserved protein 0.0109 0.1173 0.1335
Leishmania major cytochrome p450-like protein 0.0028 0.0174 0.0314
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0109 0.1173 0.1335
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0338 0.0694
Loa Loa (eye worm) hypothetical protein 0.0109 0.1173 0.251
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0391 0.4649 1
Onchocerca volvulus 0.0109 0.1173 0.3776
Echinococcus multilocularis cpg binding protein 0.0031 0.0217 0.0161
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0022 0.0013
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.2254 0.4839
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0391 0.4649 1
Echinococcus multilocularis translocator protein 0.0262 0.3057 0.3017
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0108 0.0198
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0109 0.1173 0.1335
Schistosoma mansoni cpg binding protein 0.0031 0.0217 0.0183
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0057 0.0000064738
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0114 0.0506
Brugia malayi MH2 domain containing protein 0.014 0.1555 0.3345
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.1575 0.3377
Onchocerca volvulus 0.0109 0.1173 0.3776
Giardia lamblia DINP protein human, muc B family 0.0019 0.0064 0.04
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0226 0.0193
Schistosoma mansoni lamin 0.0027 0.0163 0.0121
Schistosoma mansoni importin beta-1 0.0028 0.0173 0.0132
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.2254 0.2508
Brugia malayi Pre-SET motif family protein 0.0032 0.0226 0.0486
Loa Loa (eye worm) beta-lactamase 0.0109 0.1173 0.251
Echinococcus multilocularis chromobox protein 1 0.0074 0.0736 0.0683
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0367 0.0758
Trypanosoma brucei unspecified product 0.0019 0.0064 0.0074
Trichomonas vaginalis esterase, putative 0.0109 0.1173 0.2496
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.003 0.0029
Brugia malayi Cytochrome P450 family protein 0.0028 0.0174 0.0375
Loa Loa (eye worm) hypothetical protein 0.0262 0.3057 0.657
Brugia malayi beta-lactamase family protein 0.0109 0.1173 0.2523
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0173 0.0252
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0287 0.0231
Plasmodium vivax importin-beta 2, putative 0.0028 0.0173 0.0251
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.1173 0.2475
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0023 0.0114 0.0068
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0367 0.0731
Schistosoma mansoni lamin 0.0027 0.0163 0.0121
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0064 0.0007
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0058 0.0001
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0173 0.0311
Brugia malayi jmjC domain containing protein 0.0039 0.0308 0.0662
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0022 0.0095 0.0046
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0308 0.0286
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0367 0.0758
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.055 0.1183
Brugia malayi Cytochrome P450 family protein 0.0028 0.0174 0.0375
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0367 0.0312
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0226 0.0193
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0057 0.0123
Entamoeba histolytica hypothetical protein 0.0023 0.0108 0.017
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0057 0.0123
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.1173 0.1274
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0382 0.0763
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0074
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0057 0.006
Mycobacterium tuberculosis Conserved protein 0.0109 0.1173 0.1335
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0367 0.0731
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0141 0.0241
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0539 0.105
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.026 0.0204
Plasmodium falciparum phd finger protein, putative 0.0031 0.0207 0.0326
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0061 0.0096
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0367 0.0774
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0064 0.0074
Schistosoma mansoni cpg binding protein 0.0031 0.0217 0.0183
Echinococcus granulosus intermediate filament protein 0.0027 0.0163 0.0121
Trypanosoma brucei hypothetical protein, conserved 0.0109 0.1173 0.2475
Loa Loa (eye worm) hypothetical protein 0.0109 0.1173 0.251
Onchocerca volvulus 0.0027 0.0163 0.044
Echinococcus granulosus dna polymerase kappa 0.0019 0.0064 0.0008
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0064 0.0074
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0114 0.0188
Onchocerca volvulus 0.0114 0.1231 0.397
Schistosoma mansoni hypothetical protein 0.0424 0.5059 0.5711
Loa Loa (eye worm) hypothetical protein 0.0109 0.1173 0.251
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0212 0.0394
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0207 0.0151
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0058 0.0061
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0114 0.0506
Onchocerca volvulus 0.0044 0.0374 0.1139
Loa Loa (eye worm) hypothetical protein 0.0044 0.0373 0.0788
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0057 0.006
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0308 0.0286
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0057 0.006
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0064 0.0008
Loa Loa (eye worm) hypothetical protein 0.0053 0.0477 0.1012
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0503 0.1025
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0082 0.0053
Echinococcus granulosus snurportin 1 0.0298 0.35 0.3932
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0058 0.009
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0064 0.0103
Trypanosoma brucei Enriched in surface-labeled proteome protein 12 0.0077 0.0783 0.163
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0174 0.0359
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0391 0.4649 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.026 0.0232
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0141 0.0181
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0355 0.034
Schistosoma mansoni hypothetical protein 0.0019 0.0057 0.00000735
Loa Loa (eye worm) hypothetical protein 0.0109 0.1173 0.251
Schistosoma mansoni alpha-glucosidase 0.0169 0.1916 0.2123
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0061 0.0096
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2254 0.2209
Brugia malayi Heterochromatin protein 1 0.0074 0.0736 0.1584
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0163 0.0334
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0074
Schistosoma mansoni ap endonuclease 0.0019 0.0058 0.0001
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0023 0.0114 0.0068
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0064 0.0074
Schistosoma mansoni hypothetical protein 0.0019 0.0057 0.00000735
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0473 0.0475
Brugia malayi Disco-interacting protein 2 homolog 0.0023 0.0114 0.0244
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0319 0.3762 0.808
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0064 0.0008
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0174 0.0314
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0082 0.0114
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0064 0.0103
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.061 0.1297
Toxoplasma gondii hypothetical protein 0.0051 0.0463 0.0885
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0382 0.0763
Mycobacterium tuberculosis Conserved protein 0.0109 0.1173 0.1335
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0064 0.0008
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0141 0.0181
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0064 0.0074
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.055 0.1168
Echinococcus multilocularis lamin 0.0027 0.0163 0.0106
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0373 0.0745
Toxoplasma gondii ABC1 family protein 0.0109 0.1173 0.2429
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0697 0.8412 1
Leishmania major hypothetical protein, conserved 0.0041 0.034 0.0671
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0064 0.0074
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0064 0.0137
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.003 0.0029
Echinococcus granulosus disco interacting protein 2 0.0023 0.0114 0.0064
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0041 0.034 0.0614
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0082 0.1637
Echinococcus multilocularis dnaJ subfamily B 0.0424 0.5059 0.503
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.0174 0.0391
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0061 0.0096
Brugia malayi hypothetical protein 0.0106 0.1132 0.2436
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0391 0.4649 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0114 0.0188
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0114 0.0188
Brugia malayi RNA, U transporter 1 0.0079 0.0807 0.1736
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0074
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0212 0.0337
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0622 0.0645
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0058 0.0061
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0064 0.0022
Echinococcus granulosus geminin 0.017 0.1925 0.2132
Leishmania major hypothetical protein, conserved 0.0025 0.0141 0.0241
Mycobacterium tuberculosis Probable lipase LipE 0.0109 0.1173 0.1335
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0108 0.0198
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0074
Schistosoma mansoni hypothetical protein 0.0298 0.35 0.3932
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0057 0.0106
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0064 0.0074
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0355 0.03
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0077 0.0783 0.163
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0376 0.1145
Echinococcus granulosus tumor protein p63 0.0357 0.4229 0.4764
Echinococcus granulosus GPCR family 2 0.0019 0.0057 0.00000735
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.169 0.3595
Leishmania major hypothetical protein, conserved 0.0109 0.1173 0.2475
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0109 0.1173 0.3718
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0391 0.4649 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0204 0.0167
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0373 0.0745
Mycobacterium ulcerans lipase LipD 0.0109 0.1173 0.3718
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0391 0.4649 1
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0173 0.0117
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0226 0.017
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0082 0.016
Schistosoma mansoni hypothetical protein 0.017 0.1925 0.2132
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0108 0.017
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0174 0.0314
Mycobacterium ulcerans tryptophan-rich sensory protein 0.0262 0.3057 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0114 0.0188
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0061 0.0096
Echinococcus multilocularis lamin dm0 0.0027 0.0163 0.0106
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0023 0.0114 0.0064
Loa Loa (eye worm) hypothetical protein 0.0027 0.0157 0.032
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0079 0.017
Brugia malayi Cytochrome P450 family protein 0.0059 0.0552 0.1188
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0367 0.0731
Onchocerca volvulus 0.0032 0.0228 0.0655
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. 0.0023 0.0114 0.0068
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0023 0.0114 0.0506
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0552 0.1173
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0391 0.4649 0.4618
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0041 0.034 0.0671
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0226 0.017
Loa Loa (eye worm) MH2 domain-containing protein 0.014 0.1555 0.3334
Loa Loa (eye worm) heterochromatin protein 1 0.0074 0.0736 0.157
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0077 0.0783 0.163
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0061 0.0096
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0061 0.0096
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0064 0.0022
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0151 0.169 0.3595
Brugia malayi CXXC zinc finger family protein 0.003 0.0196 0.0422
Echinococcus multilocularis tumor protein p63 0.0357 0.4229 0.4196
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0196 0.0406
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.1575 0.1527
Schistosoma mansoni hypothetical protein 0.0035 0.026 0.0232
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0207 0.0171
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0319 0.3762 0.808
Brugia malayi cytochrome P450 0.0018 0.0057 0.0123
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0058 0.009
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0058 0.0002
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0064 0.0007
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0736 0.1555
Brugia malayi Bromodomain containing protein 0.0031 0.0207 0.0446
Brugia malayi Pre-SET motif family protein 0.0221 0.2547 0.5479
Leishmania major GTP-binding protein, putative 0.0021 0.0082 0.0114
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2254 0.2209
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0207 0.0326
Onchocerca volvulus 0.0262 0.3057 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0057 0.0106
Echinococcus multilocularis musashi 0.0027 0.0163 0.0106
Echinococcus multilocularis chromobox protein 1 0.0074 0.0736 0.0683
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0319 0.3762 0.808
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0041 0.034 0.0671
Entamoeba histolytica Ran family GTPase 0.0021 0.0082 0.0114
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.055 0.1183
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0061 0.0096
Echinococcus granulosus chromobox protein 1 0.0074 0.0736 0.0776
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0064 0.0074
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0058 0.0061
Plasmodium vivax hypothetical protein, conserved 0.0109 0.1173 0.2428
Echinococcus granulosus chromobox protein 1 0.0074 0.0736 0.0776
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0041 0.034 0.0671
Giardia lamblia PHD finger protein 15 0.0031 0.0207 1
Toxoplasma gondii Erv1 / Alr family protein 0.0041 0.034 0.0615
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0367 0.0731
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.003 0.0029
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.1575 0.1733
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0141 0.0241
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0108 0.0198
Echinococcus multilocularis peregrin 0.0031 0.0207 0.0151

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) = 0.325 uM PUBCHEM_BIOASSAY: HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488787] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.