Detailed information for compound 1336679

Basic information

Technical information
  • TDR Targets ID: 1336679
  • Name: N-[2-(4-Fluorobenzoyl)-1-benzofuran-3-yl]acet amide
  • MW: 297.28 | Formula: C17H12FNO3
  • H donors: 1 H acceptors: 2 LogP: 3.83 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)C(=O)c1oc2c(c1NC(=O)C)cccc2
  • InChi: 1S/C17H12FNO3/c1-10(20)19-15-13-4-2-3-5-14(13)22-17(15)16(21)11-6-8-12(18)9-7-11/h2-9H,1H3,(H,19,20)
  • InChiKey: LETFSEWOGTVJGG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(4-fluorobenzoyl)benzofuran-3-yl]acetamide
  • N-[2-[(4-fluorophenyl)-oxomethyl]-3-benzofuranyl]acetamide
  • N-[2-(4-fluorophenyl)carbonyl-1-benzofuran-3-yl]ethanamide
  • Acetamide, N-[2-(4-fluorobenzoyl)-3-benzofuryl]-
  • A1268/0057975
  • Oprea1_356538
  • MLS000034789
  • N-[2-(4-Fluoro-benzoyl)-benzofuran-3-yl]-acetamide
  • SMR000010581
  • ZINC00062930
  • EU-0070835
  • BAS 01508383

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) sirtuin 4 0.0059 0.0227 0.0255
Loa Loa (eye worm) cyclin domain-containing protein 0.0094 0.0461 0.0524
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0094 0.0461 0.0461
Trichomonas vaginalis CMGC family protein kinase 0.0075 0.034 0.1
Leishmania major mitotic cyclin, putative 0.0094 0.0461 0.1438
Schistosoma mansoni serine/threonine protein kinase 0.0278 0.1693 0.1688
Loa Loa (eye worm) cyclin domain-containing protein 0.0617 0.3956 0.4545
Echinococcus granulosus Diacylglycerol kinase theta 0.011 0.057 0.057
Echinococcus multilocularis chromatin regulatory protein sir2 0.0397 0.2486 0.2481
Giardia lamblia Cyclin A 0.0388 0.2425 0.7648
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0146 0.0814 0.4502
Trichomonas vaginalis cyclin B, putative 0.0388 0.2425 0.7779
Echinococcus granulosus transcription factor Dp 1 0.003 0.0039 0.0039
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0264 0.1596 0.1591
Entamoeba histolytica cyclin, domain containing protein 0.0094 0.0461 0.1438
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.17 0.542
Toxoplasma gondii malate dehydrogenase MDH 0.0027 0.0017 0.0058
Loa Loa (eye worm) thioredoxin reductase 0.0054 0.0195 0.0218
Echinococcus multilocularis Diacylglycerol kinase theta 0.011 0.057 0.0564
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0397 0.2485 0.2852
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0195 0.1137 0.6303
Brugia malayi Cyclin C 0.0094 0.0461 0.0524
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0059 0.0227 0.0633
Schistosoma mansoni serine/threonine protein kinase 0.0525 0.3341 0.3337
Schistosoma mansoni diacylglycerol kinase theta 0.011 0.057 0.0564
Loa Loa (eye worm) cyclin domain-containing protein 0.0094 0.0461 0.0524
Trichomonas vaginalis cyclins, putative 0.049 0.3109 1
Onchocerca volvulus 0.0055 0.0204 0.0637
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0146 0.0814 0.093
Brugia malayi Cyclin, N-terminal domain containing protein 0.0094 0.0461 0.0524
Brugia malayi cyclin fold protein 1 variant b 0.0094 0.0461 0.0524
Loa Loa (eye worm) hypothetical protein 0.011 0.057 0.0649
Echinococcus multilocularis cyclin A3 4 0.0094 0.0461 0.0455
Brugia malayi diacylglycerol kinase 0.011 0.057 0.0649
Echinococcus multilocularis serine:threonine protein kinase 38 0.0167 0.0948 0.0942
Brugia malayi Pre-SET motif family protein 0.0025 0.0006 0.0001
Onchocerca volvulus Glucosylceramidase homolog 0.0279 0.17 0.5459
Echinococcus multilocularis N chimaerin 0.011 0.057 0.0564
Schistosoma mansoni protein kinase 0.1523 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0031 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0041 0.0111 0.0105
Loa Loa (eye worm) RasGEF domain-containing protein 0.011 0.057 0.0649
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0059 0.0227 0.0633
Loa Loa (eye worm) cyclin domain-containing protein 0.0094 0.0461 0.0524
Echinococcus granulosus cyclins 0.0388 0.2425 0.2425
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0127 0.0681 0.0675
Trypanosoma brucei SIR2-like protein 4, putative 0.0059 0.0227 0.0139
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0059 0.0227 0.0227
Entamoeba histolytica protein kinase, putative 0.0167 0.0948 0.3011
Loa Loa (eye worm) hypothetical protein 0.0102 0.052 0.0592
Loa Loa (eye worm) hypothetical protein 0.0202 0.1182 0.1354
Toxoplasma gondii histone deacetylase SIR2-like 0.0059 0.0227 0.1232
Brugia malayi hypothetical protein 0.0043 0.0126 0.0139
Echinococcus multilocularis mitogen activated protein kinase 0.0075 0.034 0.0334
Echinococcus granulosus cyclins 0.0388 0.2425 0.2425
Echinococcus multilocularis raf serine:threonine protein kinase 0.011 0.057 0.0564
Trichomonas vaginalis CMGC family protein kinase 0.0146 0.0814 0.2541
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0198 0.1155 0.1322
Loa Loa (eye worm) hypothetical protein 0.0094 0.0461 0.0524
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0094 0.0461 0.2535
Brugia malayi Protein kinase domain containing protein 0.0414 0.2597 0.2981
Plasmodium vivax malate dehydrogenase, putative 0.0027 0.0017 0.0062
Onchocerca volvulus 0.035 0.2171 0.6976
Trichomonas vaginalis cyclins, putative 0.049 0.3109 1
Onchocerca volvulus 0.0029 0.0029 0.0073
Brugia malayi C1-like domain containing protein 0.0124 0.0666 0.076
Loa Loa (eye worm) transcriptional regulator 0.0059 0.0227 0.0255
Echinococcus granulosus cyclin dependent kinase 1 0.0146 0.0814 0.0814
Brugia malayi follicle stimulating hormone receptor 0.0198 0.1155 0.1322
Trypanosoma cruzi hypothetical protein, conserved 0.0094 0.0461 0.094
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0152 0.0851 0.2661
Loa Loa (eye worm) hypothetical protein 0.0378 0.2357 0.2705
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0195 0.1137 0.1302
Leishmania major protein kinase A catalytic subunit 0.0278 0.1693 0.5421
Plasmodium vivax cyclin homologue, putative 0.0094 0.0461 0.2697
Leishmania major protein kinase, putative 0.0195 0.1137 0.3624
Schistosoma mansoni g1/s-specific cyclin C 0.0094 0.0461 0.0455
Echinococcus multilocularis cyclins 0.0388 0.2425 0.2421
Brugia malayi protein kinase C II. 0.0525 0.3341 0.3837
Trichomonas vaginalis conserved hypothetical protein 0.0094 0.0461 0.1393
Loa Loa (eye worm) hypothetical protein 0.049 0.3109 0.357
Brugia malayi Protein kinase domain containing protein 0.0029 0.0029 0.0027
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0167 0.0948 0.1084
Trichomonas vaginalis conserved hypothetical protein 0.0094 0.0461 0.1393
Echinococcus multilocularis G1:S specific cyclin D1 0.0094 0.0461 0.0455
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0397 0.2486 0.7975
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0414 0.2597 0.2981
Schistosoma mansoni cyclin B 0.049 0.3109 0.3104
Loa Loa (eye worm) hypothetical protein 0.0476 0.301 0.3456
Plasmodium falciparum protein kinase 5 0.0146 0.0814 0.331
Loa Loa (eye worm) cyclin domain-containing protein 0.0094 0.0461 0.0524
Schistosoma mansoni survival motor neuron protein 0.0041 0.0111 0.0105
Echinococcus granulosus Cyclin L1 0.0094 0.0461 0.0461
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0052 0.0187 0.0208
Trichomonas vaginalis cyclins, putative 0.049 0.3109 1
Trichomonas vaginalis set domain proteins, putative 0.0202 0.1185 0.3745
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0111 0.0121
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.1137 0.3592
Entamoeba histolytica cyclin, putative 0.0388 0.2425 0.779
Giardia lamblia Kinase, CMGC MAPK 0.0075 0.034 0.0468
Schistosoma mansoni rac gtpase activating protein 0.011 0.057 0.0564
Echinococcus multilocularis protein kinase c eta type 0.011 0.057 0.0564
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0167 0.0948 0.1084
Giardia lamblia Cyclin B-like protein 0.0094 0.0461 0.0885
Schistosoma mansoni hypothetical protein 0.0043 0.0126 0.012
Schistosoma mansoni hypothetical protein 0.0094 0.0461 0.0455
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.011 0.057 0.0564
Entamoeba histolytica protein kinase, putative 0.0167 0.0948 0.3011
Loa Loa (eye worm) hypothetical protein 0.035 0.2171 0.2491
Brugia malayi Cyclin, N-terminal domain containing protein 0.0094 0.0461 0.0524
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0205 0.0199
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.1328 0.8699 1
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0059 0.0227 0.0221
Schistosoma mansoni unc-13 (munc13) 0.0127 0.0681 0.0675
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0278 0.1693 0.1688
Echinococcus multilocularis cyclin B3 1 0.0388 0.2425 0.2421
Brugia malayi Protein kinase domain containing protein 0.0167 0.0948 0.1084
Trypanosoma cruzi cyclin 6, putative 0.049 0.3109 1
Echinococcus multilocularis lactate dehydrogenase a 0.0027 0.0017 0.001
Loa Loa (eye worm) hypothetical protein 0.0127 0.0681 0.0777
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0094 0.0461 0.0461
Echinococcus multilocularis serine threonine protein kinase 0.0549 0.35 0.3496
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0617 0.3956 0.3956
Echinococcus granulosus cyclins 0.0388 0.2425 0.2425
Plasmodium falciparum calcium-dependent protein kinase 4 0.0195 0.1137 0.4652
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0001
Echinococcus granulosus cyclin y 0.0094 0.0461 0.0461
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0195 0.1137 0.1137
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0525 0.3341 0.3837
Onchocerca volvulus 0.0041 0.0111 0.0337
Trichomonas vaginalis AGC family protein kinase 0.0167 0.0948 0.2975
Schistosoma mansoni chromatin regulatory protein sir2 0.0397 0.2486 0.2481
Echinococcus multilocularis cyclin 0.0094 0.0461 0.0455
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0278 0.1693 1
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0227 0.131
Echinococcus multilocularis cyclin G2 0.0094 0.0461 0.0455
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0278 0.1693 0.1688
Trichomonas vaginalis conserved hypothetical protein 0.0094 0.0461 0.1393
Schistosoma mansoni serine/threonine protein kinase 0.0146 0.0814 0.0808
Trypanosoma cruzi cyclin, putative 0.049 0.3109 1
Giardia lamblia Sirtuin type 2 0.0059 0.0227 0.008
Schistosoma mansoni serine/threonine protein kinase 0.0167 0.0948 0.0942
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0094 0.0461 0.094
Trichomonas vaginalis glucosylceramidase, putative 0.0426 0.2676 0.8594
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0278 0.1693 0.1693
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0397 0.2486 0.2486
Brugia malayi lactate dehydrogenase. 0.0027 0.0017 0.0013
Echinococcus multilocularis mitogen activated protein kinase 3 0.0075 0.034 0.0334
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0042 0.0036
Schistosoma mansoni protein kinase C 0.0127 0.0681 0.0675
Echinococcus multilocularis unc 13 (munc13) 0.0127 0.0681 0.0675
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0031 0.0046 0.004
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0124 0.0666 0.076
Brugia malayi Cam kinase protein 1 0.0195 0.1137 0.1302
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0414 0.2597 0.2981
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0167 0.0948 0.1084
Echinococcus granulosus lactate dehydrogenase protein 0.0027 0.0017 0.0017
Plasmodium vivax protein kinase Crk2 0.0146 0.0814 0.479
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0075 0.034 0.1046
Loa Loa (eye worm) hypothetical protein 0.035 0.2171 0.2491
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0094 0.0461 0.2697
Plasmodium falciparum cyclin 1 0.0094 0.0461 0.1845
Schistosoma mansoni serine/threonine protein kinase 0.0414 0.2597 0.2593
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0052 0.0187 0.018
Onchocerca volvulus 0.049 0.3109 1
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0059 0.0227 0.0139
Echinococcus granulosus chromatin regulatory protein sir2 0.0397 0.2486 0.2486
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0031 0.0042 0.0042
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0617 0.3956 0.3952
Brugia malayi transcriptional regulator, Sir2 family protein 0.0397 0.2486 0.2853
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0195 0.1137 0.3254
Trypanosoma cruzi cdc2-related kinase 3 0.0146 0.0814 0.2147
Leishmania major cyclin 0.049 0.3109 1
Trichomonas vaginalis cyclin B3, putative 0.0094 0.0461 0.1393
Giardia lamblia Transcriptional regulator, Sir2 family 0.0059 0.0227 0.008
Schistosoma mansoni cyclin d 0.0094 0.0461 0.0455
Schistosoma mansoni serine/threonine protein kinase 0.0659 0.4233 0.4229
Leishmania major cyclin 9, putative 0.0094 0.0461 0.1438
Trichomonas vaginalis cyclin B, putative 0.049 0.3109 1
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0278 0.1693 0.1688
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0397 0.2486 0.7868
Trichomonas vaginalis AGC family protein kinase 0.0167 0.0948 0.2975
Loa Loa (eye worm) hypothetical protein 0.046 0.2904 0.3334
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0397 0.2486 0.7868
Echinococcus multilocularis cyclins 0.0388 0.2425 0.2421
Plasmodium falciparum calcium-dependent protein kinase 5 0.0195 0.1137 0.4652
Trichomonas vaginalis CMGC family protein kinase 0.0075 0.034 0.1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0278 0.1693 0.5421
Mycobacterium ulcerans Sir2-like regulatory protein 0.0059 0.0227 0.5
Onchocerca volvulus 0.0378 0.2357 0.7578
Trichomonas vaginalis glucosylceramidase, putative 0.0426 0.2676 0.8594
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.011 0.057 0.0564
Loa Loa (eye worm) hypothetical protein 0.006 0.0238 0.0268
Schistosoma mansoni microtubule-associated protein tau 0.0589 0.3764 0.376
Plasmodium falciparum calcium-dependent protein kinase 1 0.0195 0.1137 0.4652
Plasmodium falciparum cyclin 0.0388 0.2425 1
Loa Loa (eye worm) hypothetical protein 0.035 0.2171 0.2491
Brugia malayi Protein kinase domain containing protein 0.0146 0.0814 0.093
Giardia lamblia Kinase, CMGC CDK 0.0146 0.0814 0.21
Echinococcus multilocularis protein kinase c iota type 0.0472 0.2986 0.2982
Brugia malayi NAD-dependent deacetylase SIRT1 0.0059 0.0227 0.0255
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0167 0.0948 0.1084
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0059 0.0227 0.0139
Schistosoma mansoni protein kinase C mu 0.011 0.057 0.0564
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0075 0.034 0.1046
Echinococcus granulosus Protein kinase C brain isozyme 0.0659 0.4233 0.4233
Schistosoma mansoni chromatin regulatory protein sir2 0.0059 0.0227 0.0221
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0177 0.1021 0.1168
Brugia malayi Cyclin, N-terminal domain containing protein 0.0538 0.3428 0.3937
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0059 0.0227 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0052 0.0187 0.0549
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0167 0.0948 0.0942
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.17 0.542
Echinococcus granulosus protein kinase c iota type 0.0472 0.2986 0.2986
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0059 0.0227 0.008
Leishmania major trypanothione reductase 0.0054 0.0195 0.0577
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0278 0.1693 0.9399
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0041 0.0111 0.0121
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0059 0.0227 0.0633
Echinococcus multilocularis lactate dehydrogenase protein 0.0027 0.0017 0.001
Loa Loa (eye worm) hypothetical protein 0.011 0.057 0.0649
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0397 0.2486 0.2481
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0195 0.1137 0.1132
Entamoeba histolytica protein kinase, putative 0.0055 0.0204 0.0606
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0055 0.0204 0.0198
Trichomonas vaginalis cyclin B, putative 0.049 0.3109 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0205 0.023
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0124 0.0666 0.0661
Echinococcus granulosus cyclin A3 4 0.0094 0.0461 0.0461
Onchocerca volvulus Protein CNPPD1 homolog 0.0094 0.0461 0.1466
Echinococcus multilocularis cyclins 0.0388 0.2425 0.2421
Giardia lamblia Cyclin fold protein 1, putative 0.0094 0.0461 0.0885
Loa Loa (eye worm) STE/STE11/MEKK2 protein kinase 0.0029 0.0029 0.0027
Echinococcus granulosus cyclin dependent kinase 0.0146 0.0814 0.0814
Echinococcus multilocularis expressed protein 0.0318 0.1961 0.1956
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0264 0.1596 0.1596
Echinococcus granulosus cyclin 0.0094 0.0461 0.0461
Echinococcus granulosus calcium dependent protein kinase 0.018 0.1041 0.1041
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0195 0.1137 0.1132
Echinococcus multilocularis microtubule associated protein 2 0.0589 0.3764 0.376
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0414 0.2597 0.2593
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0397 0.2486 0.7975
Loa Loa (eye worm) transcriptional regulator 0.0059 0.0227 0.0255
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0031 0.0046 0.0047
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0059 0.0227 0.0681
Entamoeba histolytica PH domain containing protein kinase, putative 0.0278 0.1693 0.5421
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0414 0.2597 0.2597
Brugia malayi Hr1 repeat family protein 0.0167 0.0948 0.1084
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0195 0.1137 0.1302
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.049 0.3109 1
Toxoplasma gondii thioredoxin reductase 0.0054 0.0195 0.1053
Brugia malayi Cyclin, N-terminal domain containing protein 0.049 0.3109 0.357
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0059 0.0227 0.0139
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0397 0.2486 0.7985
Loa Loa (eye worm) hypothetical protein 0.0195 0.1137 0.1302
Echinococcus granulosus cyclin dependent kinase 5 0.0146 0.0814 0.0814
Toxoplasma gondii AGC kinase 0.0278 0.1693 0.9399
Brugia malayi Cyclin, N-terminal domain containing protein 0.049 0.3109 0.357
Trypanosoma cruzi mitotic cyclin, putative 0.0094 0.0461 0.094
Trichomonas vaginalis AGC family protein kinase 0.0167 0.0948 0.2975
Plasmodium vivax lactate dehydrogenase 0.0027 0.0017 0.0062
Mycobacterium ulcerans NAD-dependent deacetylase 0.0059 0.0227 0.5
Trichomonas vaginalis AGC family protein kinase 0.0167 0.0948 0.2975
Schistosoma mansoni chromatin regulatory protein sir2 0.0397 0.2486 0.2481
Echinococcus granulosus cyclins 0.0388 0.2425 0.2425
Loa Loa (eye worm) AGC/PKN protein kinase 0.0167 0.0948 0.1084
Loa Loa (eye worm) hypothetical protein 0.011 0.057 0.0649
Echinococcus granulosus N chimaerin 0.011 0.057 0.057
Entamoeba histolytica protein kinase, putative 0.0195 0.1137 0.3624
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0205 0.0199
Trypanosoma cruzi cdc2-related kinase 1 0.0146 0.0814 0.2147
Giardia lamblia Hypothetical protein 0.0388 0.2425 0.7648
Echinococcus granulosus cyclin k 0.0094 0.0461 0.0461
Echinococcus granulosus cyclin B 0.049 0.3109 0.3109
Plasmodium falciparum glycogen synthase kinase 3 0.0055 0.0204 0.0778
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0075 0.034 0.0525
Giardia lamblia Hypothetical protein 0.0094 0.0461 0.0885
Trichomonas vaginalis glucosylceramidase, putative 0.0426 0.2676 0.8594
Trypanosoma cruzi cyclin, putative 0.049 0.3109 1
Trichomonas vaginalis cyclin B3, putative 0.0388 0.2425 0.7779
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0094 0.0461 0.0524
Trichomonas vaginalis cyclins, putative 0.0196 0.1144 0.3615
Echinococcus multilocularis cyclin dependent kinase 1 0.0146 0.0814 0.0808
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0059 0.0227 0.0221
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0075 0.034 0.0525
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0278 0.1693 0.5154
Echinococcus multilocularis thioredoxin glutathione reductase 0.0054 0.0195 0.0189
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0094 0.0461 0.0455
Echinococcus granulosus myotubularin protein 13 0.011 0.057 0.057
Leishmania major protein kinase A catalytic subunit isoform 2 0.0278 0.1693 0.5421
Trichomonas vaginalis CMGC family protein kinase 0.0075 0.034 0.1
Brugia malayi diacylglycerol kinase 0.011 0.057 0.0649
Echinococcus granulosus mitogen activated protein kinase 3 0.0075 0.034 0.034
Schistosoma mansoni cyclin k 0.0094 0.0461 0.0455
Brugia malayi Cyclin, N-terminal domain containing protein 0.0094 0.0461 0.0524
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0205 0.0199
Trypanosoma cruzi cdc2-related kinase 1 0.0146 0.0814 0.2147
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.17 0.542
Echinococcus multilocularis RNA directed DNA polymerase 0.0366 0.2277 0.2272
Loa Loa (eye worm) AGC/PKA protein kinase 0.0278 0.1693 0.1941
Toxoplasma gondii cyclin dependent kinase binding protein 0.0094 0.0461 0.2535
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0094 0.0461 0.0455
Trypanosoma brucei cdc2-related kinase 3 0.0146 0.0814 0.2147
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0278 0.1693 0.1941
Echinococcus multilocularis lactate dehydrogenase a 0.0027 0.0017 0.001
Plasmodium vivax hypothetical protein, conserved 0.0094 0.0461 0.2697
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0414 0.2597 0.8352
Plasmodium vivax glycogen synthase kinase 3, putative 0.0055 0.0204 0.1173
Leishmania major silent information regulator 2, putative 0.0397 0.2486 0.7985
Plasmodium vivax thioredoxin reductase, putative 0.0054 0.0195 0.112
Echinococcus multilocularis Protein lozenge 0.0047 0.0153 0.0146
Plasmodium vivax cyclin 4, putative 0.0094 0.0461 0.2697
Schistosoma mansoni hypothetical protein 0.0041 0.0111 0.0105
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0059 0.0227 0.0633
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0059 0.0227 0.0227
Trypanosoma brucei mitotic cyclin 0.0094 0.0461 0.094
Schistosoma mansoni atypical protein kinase C 0.0486 0.3082 0.3078
Schistosoma mansoni chromatin regulatory protein sir2 0.0397 0.2486 0.2481
Trichomonas vaginalis cyclins, putative 0.0094 0.0461 0.1393
Loa Loa (eye worm) hypothetical protein 0.0132 0.0717 0.0819
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0195 0.1137 0.6303
Trichomonas vaginalis cyclin B, putative 0.0094 0.0461 0.1393
Brugia malayi hypothetical protein 0.0094 0.0461 0.0524
Echinococcus multilocularis survival motor neuron protein 1 0.0202 0.1182 0.1177
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.17 0.542
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0052 0.0187 0.018
Echinococcus granulosus cyclin G2 0.0094 0.0461 0.0461
Echinococcus multilocularis Cyclin L1 0.0094 0.0461 0.0455
Echinococcus granulosus unc 13 munc13 0.0127 0.0681 0.0681
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0334 0.2067 0.2372
Trypanosoma cruzi cyclin 9, putative 0.0094 0.0461 0.094
Echinococcus granulosus RNA directed DNA polymerase 0.0366 0.2277 0.2277
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0195 0.1137 0.6707
Schistosoma mansoni unc-13 (munc13) 0.0127 0.0681 0.0675
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0278 0.1693 0.6958
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.17 0.542
Toxoplasma gondii histone deacetylase SIR2 0.0059 0.0227 0.1232
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0278 0.1693 0.5154
Leishmania major protein kinase A catalytic subunit isoform 1 0.0278 0.1693 0.5421
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0059 0.0227 0.0633
Schistosoma mansoni diacylglycerol kinase theta 0.011 0.057 0.0564
Brugia malayi hypothetical protein 0.0094 0.0461 0.0524
Schistosoma mansoni hypothetical protein 0.0094 0.0461 0.0455
Echinococcus granulosus NDR protein kinase 0.0167 0.0948 0.0948
Onchocerca volvulus 0.0202 0.1185 0.3798
Trypanosoma brucei cyclin 9 0.0094 0.0461 0.094
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0094 0.0461 0.2535
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0059 0.0227 0.0633
Schistosoma mansoni serine/threonine protein kinase 0.011 0.057 0.0564
Echinococcus granulosus expressed protein 0.0318 0.1961 0.1961
Loa Loa (eye worm) RhoGAP domain-containing protein 0.011 0.057 0.0649
Echinococcus multilocularis myotubularin protein 13 0.011 0.057 0.0564
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0055 0.0204 0.0228
Schistosoma mansoni chromatin regulatory protein sir2 0.0059 0.0227 0.0221
Echinococcus granulosus Rac GTPase activating protein 1 0.011 0.057 0.057
Trichomonas vaginalis conserved hypothetical protein 0.0094 0.0461 0.1393
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0426 0.2676 0.3072
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0204 0.0606
Schistosoma mansoni serine/threonine kinase 0.0167 0.0948 0.0942
Loa Loa (eye worm) hypothetical protein 0.0378 0.2357 0.2705
Echinococcus granulosus serine:threonine protein kinase N2 0.0167 0.0948 0.0948
Loa Loa (eye worm) transcriptional regulator 0.0397 0.2486 0.2853
Brugia malayi Cyclin, N-terminal domain containing protein 0.0617 0.3956 0.4545
Echinococcus granulosus cyclin t1 0.0094 0.0461 0.0461
Echinococcus multilocularis cyclins 0.0388 0.2425 0.2421
Loa Loa (eye worm) hypothetical protein 0.049 0.3109 0.357
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0205 0.0205
Entamoeba histolytica hypothetical protein 0.0043 0.0126 0.0355
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0124 0.0666 0.076
Echinococcus granulosus protein kinase c epsilon type 0.0525 0.3341 0.3341
Brugia malayi Variant SH3 domain containing protein 0.011 0.057 0.0649
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0195 0.1137 0.6303
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0059 0.0227 0.0633
Loa Loa (eye worm) cyclin C 0.0094 0.0461 0.0524
Loa Loa (eye worm) variant SH3 domain-containing protein 0.011 0.057 0.0649
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0052 0.0187 0.0187
Toxoplasma gondii diacylglycerol kinase, putative 0.011 0.057 0.3139
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0066 0.0059
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0278 0.1693 0.5154
Echinococcus granulosus cyclin G2 0.0094 0.0461 0.0461
Entamoeba histolytica protein kinase domain containing protein 0.0055 0.0204 0.0606
Loa Loa (eye worm) raf kinase 0.011 0.057 0.0649
Plasmodium falciparum glutathione reductase 0.0054 0.0195 0.0741
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0238 0.0268
Trichomonas vaginalis CMGC family protein kinase 0.0075 0.034 0.1
Echinococcus multilocularis cyclin y 0.0094 0.0461 0.0455
Giardia lamblia G2/mitotic-specific cyclin B 0.049 0.3109 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0126 0.0126
Loa Loa (eye worm) AGC/NDR protein kinase 0.0167 0.0948 0.1084
Echinococcus granulosus histone lysine methyltransferase setb 0.0025 0.0006 0.0006
Trypanosoma cruzi cdc2-related kinase 3 0.0146 0.0814 0.2147
Brugia malayi p70 ribosomal S6 kinase beta 0.0167 0.0948 0.1084
Schistosoma mansoni malate dehydrogenase 0.0027 0.0017 0.001
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0195 0.1137 0.1137
Toxoplasma gondii cyclin 4, putative 0.0094 0.0461 0.2535
Brugia malayi RhoGAP domain containing protein 0.011 0.057 0.0649
Trichomonas vaginalis AGC family protein kinase 0.0167 0.0948 0.2975
Echinococcus granulosus cyclin y 0.0094 0.0461 0.0461
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0031 0.0042 0.0042
Schistosoma mansoni cyclins 0.0388 0.2425 0.2421
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0059 0.0227 0.0681
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0146 0.0814 0.2579
Brugia malayi Cyclin, N-terminal domain containing protein 0.0094 0.0461 0.0524
Schistosoma mansoni serine/threonine protein kinase 0.0167 0.0948 0.0942
Echinococcus multilocularis transcription factor Dp 1 0.003 0.0039 0.0033
Echinococcus multilocularis cyclin B 0.049 0.3109 0.3104
Toxoplasma gondii AGC kinase 0.0167 0.0948 0.5247
Trichomonas vaginalis cyclin D, putative 0.0094 0.0461 0.1393
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0094 0.0461 0.1845
Echinococcus multilocularis beta adrenergic receptor kinase 0.0031 0.0042 0.0036
Echinococcus multilocularis cyclins 0.0388 0.2425 0.2421
Brugia malayi Ras association domain family 1 isoform A 0.011 0.057 0.0649
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0055 0.0204 0.006
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0146 0.0814 0.093
Echinococcus granulosus G1:S specific cyclin D1 0.0094 0.0461 0.0461
Echinococcus multilocularis cyclin y 0.0094 0.0461 0.0455
Trichomonas vaginalis cyclin B, putative 0.0094 0.0461 0.1393
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0075 0.034 0.0525
Entamoeba histolytica diacylglycerol kinase, putative 0.011 0.057 0.1788
Trypanosoma brucei trypanothione reductase 0.0054 0.0195 0.0029
Trichomonas vaginalis CMGC family protein kinase 0.0146 0.0814 0.2541
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0055 0.0204 0.0198
Loa Loa (eye worm) hypothetical protein 0.011 0.057 0.0649
Entamoeba histolytica cyclin, domain containing protein 0.0094 0.0461 0.1438
Echinococcus granulosus mitogen activated protein kinase 0.0075 0.034 0.034
Trichomonas vaginalis AGC family protein kinase 0.0167 0.0948 0.2975
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0204 0.0558
Schistosoma mansoni hypothetical protein 0.011 0.057 0.0564
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0205 0.0199
Toxoplasma gondii hypothetical protein 0.0094 0.0461 0.2535
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0146 0.0814 0.0814
Loa Loa (eye worm) hypothetical protein 0.011 0.057 0.0649
Brugia malayi intracellular kinase 0.0055 0.0204 0.0228
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0055 0.0204 0.0204
Trichomonas vaginalis AGC family protein kinase 0.0167 0.0948 0.2975
Schistosoma mansoni serine/threonine protein kinase 0.0124 0.0666 0.0661
Onchocerca volvulus Cyclin L homolog 0.0094 0.0461 0.1466
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0059 0.0227 0.0633
Brugia malayi Pre-SET motif family protein 0.0177 0.1021 0.1168
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0278 0.1693 0.5154
Entamoeba histolytica hypothetical protein 0.011 0.057 0.1788
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0059 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0027 0.0017 0.0013
Echinococcus granulosus thioredoxin glutathione reductase 0.0054 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.0059 0.0227 0.0255
Echinococcus granulosus microtubule associated protein 2 0.0589 0.3764 0.3764
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0127 0.0681 0.0681
Loa Loa (eye worm) glutathione reductase 0.0054 0.0195 0.0218
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0278 0.1693 0.5154
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0059 0.0227 0.0874
Echinococcus granulosus survival motor neuron protein 1 0.0202 0.1182 0.1182
Echinococcus granulosus protein kinase shaggy 0.0055 0.0204 0.0204
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0042 0.0036
Entamoeba histolytica protein kinase, putative 0.0212 0.1249 0.3985
Schistosoma mansoni protein kinase 0.1523 1 1
Schistosoma mansoni cyclin G 0.0094 0.0461 0.0455
Trypanosoma brucei cyclin 3 0.0094 0.0461 0.094
Trypanosoma brucei protein kinase, putative 0.0055 0.0204 0.006
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0146 0.0814 0.093
Echinococcus multilocularis protein kinase c epsilon type 0.0525 0.3341 0.3337
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0397 0.2486 0.7868
Trichomonas vaginalis cyclin A, putative 0.049 0.3109 1
Echinococcus granulosus lactate dehydrogenase a 0.0027 0.0017 0.0017
Echinococcus granulosus cyclins 0.0388 0.2425 0.2425
Brugia malayi Cyclin, N-terminal domain containing protein 0.0094 0.0461 0.0524
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0015
Loa Loa (eye worm) hypothetical protein 0.0041 0.0111 0.0121
Schistosoma mansoni vav2 0.011 0.057 0.0564
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0094 0.0461 0.1845
Toxoplasma gondii hypothetical protein 0.0294 0.1801 1
Echinococcus multilocularis cyclin dependent kinase 5 0.0146 0.0814 0.0808
Brugia malayi hypothetical protein 0.0202 0.1182 0.1354
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0195 0.1137 0.6707
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0126 0.012
Entamoeba histolytica hypothetical protein 0.0043 0.0126 0.0355
Brugia malayi transcriptional regulator, Sir2 family protein 0.0059 0.0227 0.0255
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.0027 0.0017 0.5
Echinococcus granulosus cyclin b3 0.0388 0.2425 0.2425
Schistosoma mansoni Cyclin fold protein 0.0094 0.0461 0.0455
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0075 0.034 0.0385
Onchocerca volvulus Cyclin L homolog 0.0094 0.0461 0.1466
Trichomonas vaginalis CMGC family protein kinase 0.0146 0.0814 0.2541
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0055 0.0204 0.1102
Brugia malayi glutathione reductase 0.0054 0.0195 0.0218
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0278 0.1693 0.5154
Brugia malayi RhoGEF domain containing protein 0.011 0.057 0.0649
Trypanosoma brucei protein kinase, putative 0.0075 0.034 0.0525
Trichomonas vaginalis cyclins, putative 0.049 0.3109 1
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.034 0.0334
Plasmodium vivax NAD-dependent deacetylase, putative 0.0059 0.0227 0.131
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0124 0.0666 0.0666
Giardia lamblia Hypothetical protein 0.0397 0.2486 0.7856
Schistosoma mansoni serine/threonine protein kinase 0.0167 0.0948 0.0942
Entamoeba histolytica cyclin C, putative 0.0094 0.0461 0.1438
Trichomonas vaginalis AGC family protein kinase 0.0278 0.1693 0.5397
Loa Loa (eye worm) hypothetical protein 0.0278 0.1693 0.1941
Schistosoma mansoni L-lactate dehydrogenase 0.0027 0.0017 0.001
Trichomonas vaginalis cyclins, putative 0.0388 0.2425 0.7779
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.011 0.057 0.057
Echinococcus granulosus cyclin B3 1 0.0388 0.2425 0.2425
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0278 0.1693 0.1693
Entamoeba histolytica protein kinase, putative 0.0167 0.0948 0.3011
Echinococcus multilocularis cyclin dependent kinase 1 0.0146 0.0814 0.0808
Trichomonas vaginalis cyclin D, putative 0.0388 0.2425 0.7779
Schistosoma mansoni chromatin regulatory protein sir2 0.0059 0.0227 0.0221
Giardia lamblia Kinase, CMGC CDK 0.0146 0.0814 0.21
Plasmodium falciparum calcium-dependent protein kinase 3 0.0195 0.1137 0.4652
Leishmania major mitotic cyclin, putative 0.0094 0.0461 0.1438
Echinococcus granulosus protein kinase c eta type 0.011 0.057 0.057
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0167 0.0948 0.0942
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0278 0.1693 0.1693
Giardia lamblia Kinase, AGC PKA 0.0278 0.1693 0.5125
Entamoeba histolytica cell division protein kinase 2, putative 0.0146 0.0814 0.2579
Entamoeba histolytica hypothetical protein 0.0094 0.0461 0.1438
Loa Loa (eye worm) cyclin domain-containing protein 0.0538 0.3428 0.3937
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0059 0.0227 0.0874
Trypanosoma cruzi CYC2-like cyclin, putative 0.049 0.3109 1
Trypanosoma brucei rac serine-threonine kinase, putative 0.0167 0.0948 0.2605
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0059 0.0227 0.0221
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0205 0.0199
Entamoeba histolytica protein kinase, putative 0.0167 0.0948 0.3011
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.011 0.057 0.0564
Schistosoma mansoni cyclin G2 0.0094 0.0461 0.0455
Echinococcus multilocularis cyclin b3 0.0388 0.2425 0.2421
Echinococcus multilocularis cyclin G2 0.0094 0.0461 0.0455
Trichomonas vaginalis AGC family protein kinase 0.0167 0.0948 0.2975
Entamoeba histolytica cell division protein kinase 2, putative 0.0146 0.0814 0.2579
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0278 0.1693 0.1688
Brugia malayi transcriptional regulator, Sir2 family protein 0.0059 0.0227 0.0255
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0075 0.034 0.0525
Trichomonas vaginalis cyclin A, putative 0.0094 0.0461 0.1393
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0059 0.0227 0.0633
Schistosoma mansoni serine/threonine protein kinase 0.0659 0.4233 0.4229
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0205 0.023
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0042 0.0036
Brugia malayi cell division control protein 2 homolog 0.0146 0.0814 0.093
Schistosoma mansoni serine/threonine protein kinase 0.0124 0.0666 0.0661
Toxoplasma gondii AGC kinase 0.0278 0.1693 0.9399
Brugia malayi Thioredoxin reductase 0.0054 0.0195 0.0218
Echinococcus multilocularis serine:threonine protein kinase N2 0.0167 0.0948 0.0942
Brugia malayi Pleckstrin Homology Domain 0.011 0.057 0.0649
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0126 0.012
Brugia malayi Protein kinase domain containing protein 0.0124 0.0666 0.076
Loa Loa (eye worm) AGC/PKA protein kinase 0.0278 0.1693 0.1941
Entamoeba histolytica PH domain containing protein kinase, putative 0.0247 0.1482 0.4739
Plasmodium vivax calcium-dependent protein kinase, putative 0.0195 0.1137 0.6707
Schistosoma mansoni serine/threonine protein kinase 0.0278 0.1693 0.1688
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0031 0.0042 0.0042
Entamoeba histolytica diacylglycerol kinase, putative 0.011 0.057 0.1788
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0146 0.0814 0.2579
Entamoeba histolytica cyclin family protein 0.0388 0.2425 0.779
Schistosoma mansoni lozenge 0.0047 0.0153 0.0146
Echinococcus granulosus L lactate dehydrogenase B chain 0.0027 0.0017 0.0017
Trichomonas vaginalis glucosylceramidase, putative 0.0426 0.2676 0.8594
Onchocerca volvulus 0.011 0.057 0.1816
Trichomonas vaginalis glucosylceramidase, putative 0.0294 0.18 0.5746
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0366 0.2277 0.2272
Echinococcus multilocularis calcium dependent protein kinase 0.018 0.1041 0.1035
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0659 0.4233 0.4229
Loa Loa (eye worm) hypothetical protein 0.0094 0.0461 0.0524
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0059 0.0227 0.0681
Brugia malayi Protein kinase c protein 2 0.0507 0.3218 0.3696
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.17 0.542
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0066 0.0059
Schistosoma mansoni cyclin l 0.0094 0.0461 0.0455
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0204 0.0558
Schistosoma mansoni protein kinase C mu 0.0124 0.0666 0.0661
Entamoeba histolytica hypothetical protein 0.0043 0.0126 0.0355
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0052 0.0187 0.0208
Onchocerca volvulus 0.0127 0.0681 0.2176
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0031 0.0046 0.0047
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0052 0.0187 0.0549
Echinococcus multilocularis serine:threonine protein kinase N2 0.0399 0.2497 0.2492
Loa Loa (eye worm) CYL-1 protein 0.0094 0.0461 0.0524
Schistosoma mansoni serine/threonine protein kinase 0.0146 0.0814 0.0808
Onchocerca volvulus 0.011 0.057 0.1816
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.1328 0.8699 1
Trichomonas vaginalis glucosylceramidase, putative 0.0426 0.2676 0.8594
Brugia malayi MAP kinase sur-1 0.0075 0.034 0.0385
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0167 0.0948 0.0942
Echinococcus multilocularis Rac GTPase activating protein 1 0.011 0.057 0.0564
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0167 0.0948 0.0948
Loa Loa (eye worm) runx1 0.0047 0.0153 0.0169
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0167 0.0948 0.0948
Brugia malayi Cyclin, N-terminal domain containing protein 0.0094 0.0461 0.0524
Trichomonas vaginalis cyclin B, putative 0.049 0.3109 1
Onchocerca volvulus 0.0094 0.0461 0.1466
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.011 0.057 0.0649
Echinococcus multilocularis cyclins 0.0388 0.2425 0.2421
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0426 0.2676 0.3072
Trypanosoma brucei mitotic cyclin 6 0.049 0.3109 1
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0414 0.2597 0.2981
Trichomonas vaginalis conserved hypothetical protein 0.0388 0.2425 0.7779
Entamoeba histolytica hypothetical protein 0.0043 0.0126 0.0355
Trichomonas vaginalis cyclin B, putative 0.049 0.3109 1
Trichomonas vaginalis AGC family protein kinase 0.0167 0.0948 0.2975
Echinococcus granulosus serine:threonine protein kinase N2 0.0247 0.1482 0.1482
Brugia malayi Protein kinase domain containing protein 0.0167 0.0948 0.1084
Echinococcus granulosus raf serine:threonine protein kinase 0.011 0.057 0.057
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0195 0.1137 0.1132
Entamoeba histolytica hypothetical protein, conserved 0.0059 0.0227 0.0681
Brugia malayi Protein kinase domain containing protein 0.0167 0.0948 0.1084
Schistosoma mansoni chromatin regulatory protein sir2 0.0059 0.0227 0.0221
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0075 0.034 0.186
Trichomonas vaginalis glucosylceramidase, putative 0.0426 0.2676 0.8594
Echinococcus multilocularis cyclin dependent kinase 0.0146 0.0814 0.0808
Loa Loa (eye worm) hypothetical protein 0.011 0.057 0.0649
Trichomonas vaginalis cyclins, putative 0.0094 0.0461 0.1393
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0055 0.0204 0.0606
Echinococcus multilocularis cyclins 0.0388 0.2425 0.2421
Loa Loa (eye worm) cyclin domain-containing protein 0.0094 0.0461 0.0524
Entamoeba histolytica cyclin, putative 0.049 0.3109 1
Schistosoma mansoni cyclin B3 0.0617 0.3956 0.3952
Echinococcus multilocularis cyclin t1 0.0094 0.0461 0.0455
Trypanosoma cruzi trypanothione reductase, putative 0.0054 0.0195 0.0029
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0238 0.0268
Echinococcus granulosus cyclins 0.0094 0.0461 0.0461
Trichomonas vaginalis cyclin D, putative 0.0388 0.2425 0.7779
Brugia malayi RhoGAP domain containing protein 0.011 0.057 0.0649
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0167 0.0948 0.0948
Loa Loa (eye worm) hypothetical protein 0.0366 0.2277 0.2613
Entamoeba histolytica cyclin family protein 0.0388 0.2425 0.779
Trichomonas vaginalis cyclin B3, putative 0.0094 0.0461 0.1393
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0195 0.1137 0.1137
Echinococcus multilocularis L lactate dehydrogenase B chain 0.0027 0.0017 0.001
Toxoplasma gondii lactate dehydrogenase LDH1 0.0027 0.0017 0.0058
Plasmodium falciparum calcium-dependent protein kinase 2 0.0195 0.1137 0.4652
Schistosoma mansoni serine/threonine protein kinase 0.0195 0.1137 0.1132
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0055 0.0204 0.0228
Schistosoma mansoni serine/threonine protein kinase 0.0167 0.0948 0.0942
Schistosoma mansoni serine/threonine protein kinase 0.0278 0.1693 0.1688
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0397 0.2486 0.7985
Loa Loa (eye worm) hypothetical protein 0.011 0.057 0.0649
Loa Loa (eye worm) AGC/AKT protein kinase 0.0167 0.0948 0.1084
Brugia malayi protein kinase C3,putative 0.032 0.1971 0.2262
Echinococcus multilocularis cyclin k 0.0094 0.0461 0.0455
Trypanosoma cruzi mitotic cyclin, putative 0.0094 0.0461 0.094
Toxoplasma gondii lactate dehydrogenase LDH2 0.0027 0.0017 0.0058
Trichomonas vaginalis glucosylceramidase, putative 0.0279 0.17 0.542
Trichomonas vaginalis AGC family protein kinase 0.0167 0.0948 0.2975
Leishmania major sir2-family protein-like protein 0.0059 0.0227 0.0681
Trichomonas vaginalis AGC family protein kinase 0.0167 0.0948 0.2975
Entamoeba histolytica protein kinase, putative 0.0031 0.0045 0.0091
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0094 0.0461 0.0455
Echinococcus multilocularis lactate dehydrogenase a 0.0027 0.0017 0.001
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0278 0.1693 0.5154
Schistosoma mansoni protein kinase 0.1523 1 1
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0195 0.1137 0.1302
Plasmodium vivax glutathione reductase, putative 0.0054 0.0195 0.112
Trypanosoma brucei cdc2-related kinase 1 0.0146 0.0814 0.2147
Echinococcus multilocularis protein kinase shaggy 0.0055 0.0204 0.0198
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.1523 1 1
Loa Loa (eye worm) hypothetical protein 0.011 0.057 0.0649
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0238 0.0268
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0195 0.1137 0.6707
Loa Loa (eye worm) hypothetical protein 0.0516 0.3282 0.3769
Loa Loa (eye worm) hypothetical protein 0.011 0.057 0.0649
Giardia lamblia Hypothetical protein 0.0094 0.0461 0.0885
Plasmodium falciparum thioredoxin reductase 0.0054 0.0195 0.0741
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0075 0.034 0.0525
Brugia malayi hypothetical protein 0.0378 0.2357 0.2705
Echinococcus granulosus lactate dehydrogenase a 0.0027 0.0017 0.0017
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0205 0.0205
Trichomonas vaginalis glucosylceramidase, putative 0.0294 0.18 0.5746
Echinococcus granulosus beta-adrenergic receptor kinase 0.0031 0.0042 0.0042
Echinococcus granulosus protein kinase C gamma type 0.0549 0.35 0.35

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0126 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.5174 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 3.9811 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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