Detailed information for compound 1338965

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 478.562 | Formula: C22H30N4O6S
  • H donors: 2 H acceptors: 5 LogP: 3.02 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1c(NC(=O)CN2C(=O)NC3(C2=O)CCCCC3C)sc(c1C)C(=O)N(C)C
  • InChi: 1S/C22H30N4O6S/c1-6-32-19(29)15-13(3)16(18(28)25(4)5)33-17(15)23-14(27)11-26-20(30)22(24-21(26)31)10-8-7-9-12(22)2/h12H,6-11H2,1-5H3,(H,23,27)(H,24,31)
  • InChiKey: XQWBMIGJLAHWSO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni sodium-dependent amino acid transporter 0.0034 0.0281 0.0419
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0044 0.0282
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0013 0.0019 0.0034
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0034 0.0281 0.0419
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0015 0.0044 0.0102
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0015 0.0044 0.0102
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0317 0.3717 1
Schistosoma mansoni tyrosine kinase 0.0168 0.1905 0.2892
Schistosoma mansoni adenoreceptor 0.0062 0.0617 0.093
Onchocerca volvulus Neuropeptide F receptor homolog 0.0062 0.0617 0.2507
Echinococcus granulosus g protein coupled receptor 0.0062 0.0617 0.0611
Echinococcus granulosus GPCR family 2 0.0035 0.0292 0.0285
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0044 0.0102
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.0617 0.0611
Echinococcus granulosus tm gpcr rhodopsin 0.0062 0.0617 0.0611
Echinococcus granulosus sex peptide receptor 0.0062 0.0617 0.0611
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0028 0.02 0.021
Echinococcus granulosus epidermal growth factor receptor 0.0091 0.0967 0.0961
Loa Loa (eye worm) SRC-1 0.0043 0.0386 0.0608
Plasmodium vivax amine transporter, putative 0.0034 0.0281 0.0645
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0015 0.0044 0.0102
Echinococcus multilocularis dro:myosuppressin receptor 0.0062 0.0617 0.0661
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0043 0.0386 0.0411
Schistosoma mansoni opsin-like receptor 0.0062 0.0617 0.093
Loa Loa (eye worm) hypothetical protein 0.0051 0.0481 0.0761
Echinococcus granulosus mitogen activated protein kinase 14 0.0141 0.1575 0.157
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0062 0.0617 0.0661
Loa Loa (eye worm) hypothetical protein 0.0034 0.0281 0.044
Schistosoma mansoni hypothetical protein 0.0062 0.0617 0.093
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0036 0.0303 0.1926
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0043 0.0386 0.0411
Echinococcus granulosus tyrosine protein kinase Src42A 0.0037 0.031 0.0304
Echinococcus granulosus neuropeptide s receptor 0.0062 0.0617 0.0611
Trichomonas vaginalis sulfite reductase, putative 0.0028 0.02 0.3921
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0111 0.1218 0.1941
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0015 0.0044 0.0102
Echinococcus granulosus orexin receptor type 2 0.0062 0.0617 0.0611
Echinococcus multilocularis insulin receptor 0.0054 0.0525 0.0561
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0092 0.0978 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0043 0.0386 0.0411
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0092 0.0978 1
Brugia malayi hypothetical protein 0.0062 0.0617 0.2629
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.03 0.079
Echinococcus granulosus biogenic amine 5HT receptor 0.0062 0.0617 0.0611
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Echinococcus multilocularis neuropeptide receptor 0.0062 0.0617 0.0661
Brugia malayi G-protein coupled receptor 0.0062 0.0617 0.2629
Leishmania major 4-coumarate:coa ligase-like protein 0.0051 0.0481 0.3056
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0034 0.0281 0.0419
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0034 0.0281 0.0275
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0062 0.0617 0.0661
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0062 0.0617 0.093
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0292 0.0285
Leishmania major cytochrome p450-like protein 0.0012 0.0007 0.0042
Onchocerca volvulus 0.0203 0.2329 1
Brugia malayi hypothetical protein 0.0062 0.0617 0.2629
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0617 0.093
Schistosoma mansoni NADPH flavin oxidoreductase 0.0014 0.0033 0.004
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0034 0.0281 0.044
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0442 1
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0028 0.02 0.1273
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0034 0.0281 0.0297
Schistosoma mansoni hypothetical protein 0.0035 0.0292 0.0434
Schistosoma mansoni amine GPCR 0.0062 0.0617 0.093
Schistosoma mansoni amine GPCR 0.0062 0.0617 0.093
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0062 0.0617 0.2507
Echinococcus granulosus insulin receptor 0.0054 0.0525 0.0519
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0617 0.093
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0037 0.0314 0.1324
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0015 0.0044 0.0102
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Echinococcus granulosus tyrosine protein kinase Blk 0.0039 0.0336 0.033
Onchocerca volvulus 0.0062 0.0617 0.2507
Mycobacterium ulcerans hypothetical protein 0.0051 0.0481 0.128
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Schistosoma mansoni biogenic amine receptor 0.0062 0.0617 0.093
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0442 0.0436
Echinococcus multilocularis orexin receptor type 2 0.0062 0.0617 0.0661
Echinococcus granulosus neuropeptide receptor A26 0.0062 0.0617 0.0611
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0015 0.0044 0.0102
Brugia malayi P38 map kinase family protein 2 0.0141 0.1575 0.6755
Echinococcus multilocularis sodium and chloride dependent glycine 0.0034 0.0281 0.0297
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0617 0.093
Leishmania major basic transcription factor 3a, putative 0.0039 0.0335 0.2127
Schistosoma mansoni hypothetical protein 0.0058 0.0566 0.0852
Leishmania major cytochrome p450-like protein 0.0012 0.0007 0.0042
Brugia malayi hypothetical protein 0.0062 0.0617 0.2629
Brugia malayi Cytochrome P450 family protein 0.0054 0.0522 0.222
Brugia malayi hypothetical protein 0.0062 0.0617 0.2629
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0062 0.0617 0.2629
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0062 0.0617 0.0611
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0203 0.2329 0.3537
Toxoplasma gondii peptidylprolyl isomerase 0.0036 0.0303 0.6856
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0012 0.0007 0.0042
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0043 0.0386 0.0411
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0062 0.0617 0.0661
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0015 0.0044 0.0102
Loa Loa (eye worm) hypothetical protein 0.0034 0.0281 0.044
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0028 0.02 0.0523
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0481 0.128
Mycobacterium ulcerans acetyl-CoA synthetase 0.0015 0.0044 0.0102
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Echinococcus multilocularis fmrfamide receptor 0.0062 0.0617 0.0661
Echinococcus granulosus peptide allatostatin:somatostatin 0.0062 0.0617 0.0611
Loa Loa (eye worm) hypothetical protein 0.0203 0.2329 0.3721
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0317 0.3717 1
Loa Loa (eye worm) ICD-1 protein 0.0039 0.0335 0.0526
Echinococcus multilocularis epidermal growth factor receptor 0.0168 0.1905 0.2055
Loa Loa (eye worm) hypothetical protein 0.0076 0.0789 0.1254
Toxoplasma gondii hypothetical protein 0.0034 0.0281 0.6361
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0012 0.0007 0.0042
Loa Loa (eye worm) hypothetical protein 0.0092 0.0978 0.1557
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0062 0.0617 0.2629
Schistosoma mansoni amine GPCR 0.0062 0.0617 0.093
Brugia malayi hypothetical protein 0.0062 0.0617 0.2629
Schistosoma mansoni myosin xvIII 0.0062 0.0617 0.093
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0051 0.0481 0.128
Brugia malayi sulfakinin receptor protein 0.0062 0.0617 0.2629
Echinococcus multilocularis g-protein coupled receptor 0.0062 0.0617 0.0661
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0062 0.0617 0.0978
Echinococcus granulosus G protein coupled receptor 139 0.0062 0.0617 0.0611
Schistosoma mansoni alpha-1 adrenergic receptor 0.0062 0.0617 0.093
Leishmania major p450 reductase, putative 0.0028 0.02 0.1273
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0028 0.02 0.021
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0062 0.0617 0.0661
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0141 0.1575 1
Schistosoma mansoni biogenic amine receptor 0.0062 0.0617 0.093
Brugia malayi hypothetical protein 0.0062 0.0617 0.2629
Schistosoma mansoni transcription factor btf3 0.0039 0.0335 0.05
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0535 0.2275
Echinococcus multilocularis neuropeptides capa receptor 0.0062 0.0617 0.0661
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0442 1
Schistosoma mansoni tyrosine kinase 0.0089 0.0941 0.1423
Echinococcus granulosus tachykinin peptides receptor 99D 0.0062 0.0617 0.0611
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0044 0.0282
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0061
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0044 0.0163
Echinococcus granulosus 7TM GPCR rhodopsin 0.0062 0.0617 0.0611
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.0617 0.0611
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0028 0.02 0.1273
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0481 0.128
Loa Loa (eye worm) hypothetical protein 0.0034 0.0281 0.044
Loa Loa (eye worm) hypothetical protein 0.0034 0.0281 0.044
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0054 0.0525 0.0519
Brugia malayi FAD binding domain containing protein 0.0028 0.02 0.0835
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0162 0.1834 0.2783
Echinococcus granulosus serotonin receptor 0.0062 0.0617 0.0611
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0091 0.0967 0.0961
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0038 0.0325 0.0858
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.0044 0.1004
Brugia malayi protein-tyrosine kinase 0.0039 0.0336 0.142
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.0044 0.0038
Echinococcus multilocularis geminin 0.0552 0.6572 0.7106
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0442 1
Brugia malayi Serotonin receptor 0.0062 0.0617 0.2629
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.0617 0.0611
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0034 0.0281 0.6361
Onchocerca volvulus 0.0062 0.0617 0.2507
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Echinococcus granulosus alpha 1A adrenergic receptor 0.0062 0.0617 0.0611
Loa Loa (eye worm) hypothetical protein 0.0038 0.0325 0.051
Echinococcus granulosus neuropeptides capa receptor 0.0062 0.0617 0.0611
Brugia malayi hypothetical protein 0.0062 0.0617 0.2629
Brugia malayi flavodoxin family protein 0.0028 0.02 0.0835
Brugia malayi follicle stimulating hormone receptor 0.0062 0.0617 0.2629
Schistosoma mansoni hypothetical protein 0.0552 0.6572 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0535 0.0572
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0292 0.1227
Echinococcus granulosus tyrosine protein kinase Fyn 0.0043 0.0386 0.038
Echinococcus granulosus somatostatin receptor 0.0062 0.0617 0.0611
Onchocerca volvulus 0.0062 0.0617 0.2507
Echinococcus granulosus tyrosine protein kinase Src64B 0.0043 0.0386 0.038
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0062 0.0617 0.093
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0043 0.0386 0.0411
Onchocerca volvulus 0.0062 0.0617 0.2507
Entamoeba histolytica acyl-CoA synthetase, putative 0.0051 0.0481 0.4678
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0535 0.0529
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0043 0.0386 0.0411
Brugia malayi GnHR receptor homolog 0.0062 0.0617 0.2629
Schistosoma mansoni tyrosine kinase 0.0089 0.0941 0.1423
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0034 0.0281 0.1184
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0028 0.02 0.1273
Loa Loa (eye worm) hypothetical protein 0.0525 0.6247 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.0617 0.0661
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0062 0.0617 0.093
Schistosoma mansoni neuropeptide receptor 0.0062 0.0617 0.093
Plasmodium vivax acyl-CoA synthetase, putative 0.0038 0.0325 0.0764
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0044 0.0102
Brugia malayi Tachykinin-like peptides receptor 99D 0.0062 0.0617 0.2629
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0062 0.0617 0.093
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0617 0.093
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0292 0.0308
Schistosoma mansoni diflavin oxidoreductase 0.0014 0.003 0.0036
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.0617 0.0611
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0062 0.0617 0.2629
Echinococcus granulosus geminin 0.0552 0.6572 0.657
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0051 0.0481 0.128
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0044 0.0102
Echinococcus granulosus tyrosine protein kinase Fyn 0.0043 0.0386 0.038
Echinococcus granulosus tyrosine kinase 0.0039 0.0336 0.033
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0062 0.0617 0.093
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0028 0.02 0.1273
Toxoplasma gondii cytochrome p450 superfamily protein 0.0012 0.0007 0.0148
Echinococcus multilocularis mitogen activated protein kinase 11 0.0141 0.1575 0.1698
Schistosoma mansoni neuropeptide f receptor 76f 0.0062 0.0617 0.093
Schistosoma mansoni neuropeptide receptor 0.0062 0.0617 0.093
Leishmania major 4-coumarate:coa ligase-like protein 0.0051 0.0481 0.3056
Echinococcus granulosus g protein coupled receptor 0.0062 0.0617 0.0611
Echinococcus multilocularis allatostatin A receptor 0.0062 0.0617 0.0661
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0012 0.0007 0.0042
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.0394 1
Schistosoma mansoni tyrosine kinase 0.0054 0.0525 0.079
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0028 0.02 0.1273
Schistosoma mansoni growth hormone secretagogue receptor 0.0062 0.0617 0.093
Schistosoma mansoni amine GPCR 0.0062 0.0617 0.093
Echinococcus multilocularis epidermal growth factor receptor 0.0091 0.0967 0.1039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0535 0.0529
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0062 0.0617 0.0661
Brugia malayi MH2 domain containing protein 0.0144 0.1616 0.6933
Onchocerca volvulus 0.0051 0.0481 0.1913
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0015 0.0044 0.0102
Echinococcus granulosus serotonin transporter 0.0203 0.2329 0.2324
Schistosoma mansoni opsin-like receptor 0.0062 0.0617 0.093
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0044 0.0282
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0015 0.0044 0.0102
Echinococcus multilocularis neuropeptide s receptor 0.0062 0.0617 0.0661
Loa Loa (eye worm) hypothetical protein 0.0028 0.02 0.0311
Plasmodium falciparum amino acid transporter, putative 0.0034 0.0281 0.0645
Schistosoma mansoni hypothetical protein 0.0062 0.0617 0.093
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0028 0.02 0.1273
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.0044 0.0282
Onchocerca volvulus 0.0034 0.0281 0.1037
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0141 0.1575 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0062 0.0617 0.0611
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0044 0.0102
Onchocerca volvulus 0.0062 0.0617 0.2507
Brugia malayi putative neuropeptide receptor NPR1 0.0062 0.0617 0.2629
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0044 0.0163
Echinococcus granulosus fmrfamide receptor 0.0062 0.0617 0.0611
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0037 0.031 0.0329
Brugia malayi Serotonin receptor 0.0062 0.0617 0.2629
Echinococcus granulosus sodium and chloride dependent glycine 0.0034 0.0281 0.0275
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0394 0.0952
Echinococcus multilocularis methionine synthase reductase 0.0017 0.0071 0.007
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0039 0.0336 0.0357
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0034 0.0281 0.1184
Echinococcus granulosus tyrosine protein kinase Fyn 0.0043 0.0386 0.038
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0034 0.0281 0.0419
Onchocerca volvulus 0.0062 0.0617 0.2507
Brugia malayi SRC-1 0.0043 0.0386 0.1635
Brugia malayi RE15519p 0.0062 0.0617 0.2629
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0062 0.0617 0.0978
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0034 0.0281 0.0275
Entamoeba histolytica transcription factor BTF3, putative 0.0039 0.0335 0.3112
Loa Loa (eye worm) hypothetical protein 0.0034 0.0281 0.044
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0522 0.0826
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0141 0.1575 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0062 0.0617 0.0661
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0535 0.0805
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.0617 0.0661
Brugia malayi hypothetical protein 0.0062 0.0617 0.2629
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Schistosoma mansoni neuropeptide F-like receptor 0.0062 0.0617 0.093
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0535 0.0846
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.0617 0.0661
Trypanosoma brucei cytochrome P450, putative 0.0012 0.0007 0.0042
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0015 0.0044 0.0282
Plasmodium falciparum acyl-CoA synthetase 0.0038 0.0325 0.0764
Brugia malayi Melatonin receptor type 1A 0.0062 0.0617 0.2629
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0028 0.02 0.1273
Echinococcus granulosus neuropeptide FF receptor 2 0.0062 0.0617 0.0611
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.0789 0.337
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0028 0.02 0.0425
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0062 0.0617 0.093
Echinococcus granulosus allatostatin A receptor 0.0062 0.0617 0.0611
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0062 0.0617 0.0661
Brugia malayi hypothetical protein 0.0062 0.0617 0.2629
Entamoeba histolytica acyl-CoA synthetase, putative 0.0051 0.0481 0.4678
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0317 0.3717 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0062 0.0617 0.0661
Echinococcus granulosus neuropeptides capa receptor 0.0062 0.0617 0.0611
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0617 0.093
Trichomonas vaginalis rotamase, putative 0.0036 0.0303 0.6505
Echinococcus granulosus histone acetyltransferase KAT2B 0.0157 0.1778 0.1773
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Echinococcus granulosus expressed protein 0.0037 0.0314 0.0308
Loa Loa (eye worm) G-protein coupled receptor 0.0062 0.0617 0.0978
Entamoeba histolytica hypothetical protein 0.0039 0.0335 0.3112
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0034 0.0281 0.1184
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0015 0.0044 0.0102
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0062 0.0617 0.0978
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0011 0 0.5
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0062 0.0617 0.0611
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0037 0.0314 0.0493
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0044 0.0102
Loa Loa (eye worm) neuropeptide F receptor 0.0062 0.0617 0.0978
Schistosoma mansoni sodium/chloride dependent transporter 0.0035 0.0288 0.0428
Echinococcus granulosus g-protein coupled receptor 0.0062 0.0617 0.0611
Echinococcus multilocularis mitogen activated protein kinase 14 0.0141 0.1575 0.1698
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0015 0.0044 0.0102
Brugia malayi G protein-coupled receptor F59B2.13 0.0062 0.0617 0.2629
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0028 0.02 0.1273
Brugia malayi G protein-coupled receptor 0.0062 0.0617 0.2629
Schistosoma mansoni tyrosine kinase 0.0043 0.0386 0.0578
Onchocerca volvulus 0.0062 0.0617 0.2507
Onchocerca volvulus 0.0062 0.0617 0.2507
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Toxoplasma gondii NAC domain-containing protein 0.0039 0.0335 0.7573
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0314 0.6772
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0317 0.3717 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0062 0.0617 0.093
Echinococcus granulosus tm gpcr rhodopsin 0.0641 0.7654 0.7653
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0062 0.0617 0.093
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0034 0.0281 0.0419
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Trypanosoma cruzi transcription factor btf3, putative 0.0039 0.0335 0.2127
Echinococcus multilocularis tyrosine protein kinase HCK 0.0035 0.0285 0.0302
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0028 0.02 0.0194
Echinococcus multilocularis neuropeptide Y receptor 0.0062 0.0617 0.0661
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0394 0.3745
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.0617 0.0611
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0034 0.0281 0.0419
Echinococcus multilocularis tyrosine protein kinase Srms 0.0039 0.0336 0.0357
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0335 0.7303
Schistosoma mansoni hypothetical protein 0.0035 0.0292 0.0434
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Loa Loa (eye worm) hypothetical protein 0.0525 0.6247 1
Loa Loa (eye worm) solute carrier family 6 member 4 0.0203 0.2329 0.3721
Schistosoma mansoni amine GPCR 0.0062 0.0617 0.093
Loa Loa (eye worm) hypothetical protein 0.0038 0.0325 0.051
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0141 0.1575 0.2514
Schistosoma mansoni neuropeptide F-like receptor 0.0062 0.0617 0.093
Echinococcus granulosus g protein coupled receptor 0.0062 0.0617 0.0611
Schistosoma mansoni biogenic amine (5HT) receptor 0.0062 0.0617 0.093
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0062 0.0617 0.2629
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0034 0.0281 0.044
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0034 0.0281 0.8283
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0044 0.0282
Brugia malayi ORL1-like opioid receptor 0.0062 0.0617 0.2629
Loa Loa (eye worm) hypothetical protein 0.0111 0.1218 0.1941
Loa Loa (eye worm) hypothetical protein 0.0051 0.0481 0.0761
Onchocerca volvulus 0.0034 0.0281 0.1037
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0015 0.0044 0.0102
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0028 0.02 0.0194
Loa Loa (eye worm) acetyltransferase 0.0162 0.1834 0.2928
Toxoplasma gondii flavodoxin domain-containing protein 0.0014 0.003 0.0686
Brugia malayi Dopamine receptor protein 1 0.0062 0.0617 0.2629
Brugia malayi hypothetical protein 0.0034 0.0281 0.1184
Loa Loa (eye worm) hypothetical protein 0.0038 0.0325 0.051
Echinococcus granulosus biogenic amine 5HT receptor 0.0062 0.0617 0.0611
Onchocerca volvulus 0.0034 0.0281 0.1037
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0062 0.0617 0.093
Schistosoma mansoni sodium/chloride dependent transporter 0.0034 0.0281 0.0419
Loa Loa (eye worm) neuropeptide F receptor 0.0062 0.0617 0.0978
Echinococcus granulosus tyrosine protein kinase Lyn 0.0044 0.0393 0.0386
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.0617 0.0661
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0292 0.1227
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0044 0.0102
Loa Loa (eye worm) hypothetical protein 0.0034 0.0281 0.044
Echinococcus multilocularis neuropeptide receptor 0.0062 0.0617 0.0661
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.0044 0.0041
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0015 0.0044 0.0102
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0044 0.0163
Loa Loa (eye worm) hypothetical protein 0.0051 0.0481 0.0761
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0034 0.0281 0.0419
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0034 0.0281 0.0275
Echinococcus granulosus neuropeptide Y receptor 0.0062 0.0617 0.0611
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0038 0.0325 1
Plasmodium vivax flavodoxin domain containing protein 0.0025 0.0162 0.032
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0442 1
Trypanosoma brucei transcription factor BTF3, putative 0.0039 0.0335 0.2127
Leishmania major cytochrome p450-like protein 0.0012 0.0007 0.0042
Loa Loa (eye worm) FAD binding domain-containing protein 0.0028 0.02 0.0311
Echinococcus granulosus sodium and chloride dependent glycine 0.0034 0.0281 0.0275
Schistosoma mansoni neuropeptide receptor 0.0062 0.0617 0.093
Echinococcus granulosus neuropeptide receptor 0.0062 0.0617 0.0611
Brugia malayi Dopamine receptor 0.0062 0.0617 0.2629
Echinococcus granulosus dro:myosuppressin receptor 0.0062 0.0617 0.0611
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1616 0.258
Plasmodium falciparum basic transcription factor 3b, putative 0.0039 0.0335 0.0791
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.0044 0.0163
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0062 0.0617 0.093
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0044 0.0102
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0017 0.0071 0.0099
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0481 0.2045
Echinococcus multilocularis g protein coupled receptor 0.0062 0.0617 0.0661
Brugia malayi larval opioid receptor 0.0062 0.0617 0.2629
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0034 0.0281 0.0297
Leishmania major acetyl-CoA synthetase, putative 0.0015 0.0044 0.0282
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0051 0.0481 0.128
Schistosoma mansoni biogenic amine (5HT) receptor 0.0062 0.0617 0.093
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0481 0.128
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0034 0.0281 0.6361
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0054 0.0525 0.0561
Loa Loa (eye worm) TK/EGFR protein kinase 0.0168 0.1905 0.3042
Toxoplasma gondii propionate-CoA ligase 0.0015 0.0044 0.1004
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0015 0.0044 0.0102
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0281 0.0645
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0335 0.7303
Toxoplasma gondii flavodoxin domain-containing protein 0.0014 0.003 0.0686
Brugia malayi AKH receptor 0.0062 0.0617 0.2629
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0051 0.0481 0.128
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0015 0.0044 0.0102
Loa Loa (eye worm) serotonin transporter b 0.0203 0.2329 0.3721
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0025 0.0162 0.2956
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0062 0.0617 0.0611
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0051 0.0481 0.128
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0292 0.0457
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0442 0.1084
Loa Loa (eye worm) TK/INSR protein kinase 0.0054 0.0525 0.0831
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Echinococcus granulosus tyrosine protein kinase HCK 0.0035 0.0285 0.0279
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0044 0.0282
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0015 0.0044 0.0102
Echinococcus multilocularis GPCR, family 2 0.0035 0.0292 0.0308
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0043 0.0386 0.0411
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0317 0.3717 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0617 0.093
Schistosoma mansoni hypothetical protein 0.0552 0.6572 1
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0007 0.0042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0535 0.0805
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0062 0.0617 0.093
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0034 0.0281 0.0419
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0015 0.0044 0.0102
Echinococcus multilocularis neuropeptide FF receptor 2 0.0062 0.0617 0.0661
Loa Loa (eye worm) hypothetical protein 0.0038 0.0325 0.051
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0062 0.0617 0.0661
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Trichomonas vaginalis rotamase, putative 0.0037 0.0314 0.6772
Loa Loa (eye worm) hypothetical protein 0.0038 0.0325 0.051
Echinococcus multilocularis G protein coupled receptor 139 0.0062 0.0617 0.0661
Loa Loa (eye worm) oxidoreductase 0.0015 0.0044 0.0061
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0641 0.7654 0.8277
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0062 0.0617 0.0978
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1616 0.258
Loa Loa (eye worm) TK protein kinase 0.0035 0.0285 0.0446
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0062 0.0617 0.0611
Onchocerca volvulus 0.0062 0.0617 0.2507
Schistosoma mansoni hypothetical protein 0.0062 0.0617 0.093
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0044 0.0061
Echinococcus multilocularis sodium and chloride dependent glycine 0.0034 0.0281 0.0297
Echinococcus granulosus mitogen activated protein kinase 11 0.0141 0.1575 0.157
Echinococcus multilocularis G-protein coupled receptor, putative 0.0062 0.0617 0.0661
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0044 0.0102
Echinococcus granulosus transcription factor btf3 0.0039 0.0335 0.0329
Loa Loa (eye worm) hypothetical protein 0.0035 0.0292 0.0457
Loa Loa (eye worm) TYRA-2 protein 0.0062 0.0617 0.0978
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Trypanosoma cruzi p450 reductase, putative 0.0028 0.02 0.1273
Treponema pallidum hypothetical protein 0.0317 0.3717 1
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0141 0.1575 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0062 0.0617 0.0661
Schistosoma mansoni hypothetical protein 0.0062 0.0617 0.093
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0617 0.093
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0036 0.0303 0.1926
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Echinococcus multilocularis mitogen activated protein kinase 14 0.0141 0.1575 0.1698
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0062 0.0617 0.0611
Echinococcus multilocularis 0.0052 0.0491 0.0524
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0062 0.0617 0.0978
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.0044 0.0102
Loa Loa (eye worm) TK protein kinase 0.0039 0.0336 0.0529
Echinococcus multilocularis fmrfamide receptor 0.0062 0.0617 0.0661
Loa Loa (eye worm) G-protein coupled receptor 0.0062 0.0617 0.0978
Schistosoma mansoni tyrosine kinase 0.0091 0.0967 0.1463
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0535 0.0572
Echinococcus multilocularis neuropeptide receptor A26 0.0062 0.0617 0.0661
Loa Loa (eye worm) hypothetical protein 0.0203 0.2329 0.3721
Echinococcus multilocularis serotonin receptor 0.0062 0.0617 0.0661
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.0617 0.0661
Plasmodium vivax basic transcription factor 3b, putative 0.0039 0.0335 0.0791
Entamoeba histolytica protein kinase, putative 0.0035 0.0285 0.2578
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.0617 0.0661
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0034 0.0281 0.0275
Schistosoma mansoni sodium/chloride dependent transporter 0.0203 0.2329 0.3537
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0043 0.0386 0.0411
Toxoplasma gondii hypothetical protein 0.0034 0.0281 0.6361
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0617 0.093
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0481 0.2045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0535 0.0805
Onchocerca volvulus 0.0062 0.0617 0.2507
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0034 0.0281 0.0297
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0051 0.0481 0.128
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.0617 0.0611
Schistosoma mansoni rotamase 0.0037 0.0314 0.0468
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0111 0.1218 0.5216
Brugia malayi Dopamine receptor protein 2 0.0062 0.0617 0.2629
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Onchocerca volvulus 0.0062 0.0617 0.2507
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.0044 0.0282
Echinococcus granulosus neuropeptide Y receptor 0.0062 0.0617 0.0611
Schistosoma mansoni cytochrome P450 reductase 0.0028 0.02 0.0295
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Loa Loa (eye worm) hypothetical protein 0.0034 0.0281 0.044
Mycobacterium ulcerans acyl-CoA synthetase 0.0051 0.0481 0.128
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0062 0.0617 0.093
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Echinococcus multilocularis expressed protein 0.0037 0.0314 0.0333
Plasmodium falciparum transporter, putative 0.0034 0.0281 0.0645
Brugia malayi neuropeptide F receptor 0.0062 0.0617 0.2629
Onchocerca volvulus 0.0062 0.0617 0.2507
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0043 0.0386 0.038
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0335 0.7303
Brugia malayi beta-NAC-like protein 0.0039 0.0335 0.1415
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0015 0.0044 0.0102
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0062 0.0617 0.2629
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Loa Loa (eye worm) melatonin receptor type 1A 0.0062 0.0617 0.0978
Echinococcus multilocularis neuropeptide Y receptor 0.0062 0.0617 0.0661
Echinococcus multilocularis somatostatin receptor 0.0062 0.0617 0.0661
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0051 0.0481 0.128
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Echinococcus multilocularis neuropeptides capa receptor 0.0062 0.0617 0.0661
Loa Loa (eye worm) hypothetical protein 0.0203 0.2329 0.3721
Schistosoma mansoni opsin-like receptor 0.0062 0.0617 0.093
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0044 0.0163
Onchocerca volvulus 0.0062 0.0617 0.2507
Echinococcus multilocularis transcription factor btf3 0.0039 0.0335 0.0356
Echinococcus granulosus rhodopsin orphan GPCR 0.0062 0.0617 0.0611
Echinococcus multilocularis serotonin receptor 0.0062 0.0617 0.0661
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0061
Schistosoma mansoni tyrosine kinase 0.0054 0.0525 0.079
Schistosoma mansoni tyrosine kinase 0.0089 0.0941 0.1423
Onchocerca volvulus 0.0062 0.0617 0.2507
Schistosoma mansoni tyrosine kinase 0.0043 0.0386 0.0578
Echinococcus multilocularis mitogen activated protein kinase 11 0.0141 0.1575 0.1698
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0044 0.0102
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0043 0.0386 0.038
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0043 0.0386 0.0411
Trypanosoma cruzi transcription factor btf3, putative 0.0039 0.0335 0.2127
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0036 0.0303 0.1926
Brugia malayi AMP-binding enzyme family protein 0.0015 0.0044 0.0163
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0039 0.0336 0.033
Schistosoma mansoni histamine h1 receptor 0.0062 0.0617 0.093
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0162 0.1834 0.1977
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.0044 0.0061
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0012 0.0007 0.0042
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Echinococcus granulosus epidermal growth factor receptor 0.0168 0.1905 0.19
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0062 0.0617 0.0661
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0034 0.0281 0.6361
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0012 0.0007 0.0042
Echinococcus multilocularis conserved hypothetical protein 0.0771 0.9246 1
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0015 0.0044 0.1004
Schistosoma mansoni hypothetical protein 0.0076 0.0789 0.1192
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0062 0.0617 0.093
Schistosoma mansoni biogenic amine receptor 0.0062 0.0617 0.093
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.03 0.079
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0292 0.0285
Onchocerca volvulus 0.0062 0.0617 0.2507
Brugia malayi AMP-binding enzyme family protein 0.0051 0.0481 0.2045
Brugia malayi G-protein coupled receptor 0.0062 0.0617 0.2629
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0062 0.0617 0.0661
Echinococcus granulosus tm gpcr rhodopsin 0.0062 0.0617 0.0611
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0038 0.0325 0.0858
Echinococcus multilocularis serotonin transporter 0.0203 0.2329 0.2513
Brugia malayi FAD binding domain containing protein 0.0017 0.0071 0.0279
Schistosoma mansoni hypothetical protein 0.0035 0.0292 0.0434
Brugia malayi Protein kinase domain containing protein 0.0054 0.0525 0.2234
Echinococcus granulosus tyrosine protein kinase Src42A 0.0043 0.0386 0.038
Echinococcus multilocularis tyrosine protein kinase Blk 0.0039 0.0336 0.0357
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0007 0.0042
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0203 0.2329 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0292 0.0308
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0036 0.0303 0.2772
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.03 0.079
Schistosoma mansoni neuropeptide receptor 0.0062 0.0617 0.093
Schistosoma mansoni tyrosine kinase 0.0091 0.0967 0.1463
Echinococcus granulosus methionine synthase reductase 0.0017 0.0071 0.0065
Leishmania major 4-coumarate:coa ligase-like protein 0.0051 0.0481 0.3056
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0034 0.0281 0.0419
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Loa Loa (eye worm) FAD binding domain-containing protein 0.0017 0.0071 0.0104
Onchocerca volvulus 0.0062 0.0617 0.2507
Brugia malayi putative neuropeptide receptor 0.0062 0.0617 0.2629
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0036 0.03 0.079
Schistosoma mansoni acetyl-CoA synthetase 0.0015 0.0044 0.0058
Brugia malayi neuropeptide F receptor 0.0062 0.0617 0.2629
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0036 0.0303 0.1926
Brugia malayi acetyltransferase, GNAT family protein 0.0162 0.1834 0.7868
Brugia malayi Furin-like cysteine rich region family protein 0.0168 0.1905 0.8176
Schistosoma mansoni hypothetical protein 0.0035 0.0292 0.0434
Echinococcus granulosus neuropeptide receptor 0.0062 0.0617 0.0611
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0034 0.0281 0.1184
Brugia malayi hypothetical protein 0.0062 0.0617 0.2629
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0044 0.0102
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Plasmodium falciparum nitric oxide synthase, putative 0.0028 0.02 0.0425
Echinococcus multilocularis g protein coupled receptor 0.0062 0.0617 0.0661
Brugia malayi Calcitonin receptor-like protein seb-1 0.0111 0.1218 0.5216
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.0617 0.0661
Loa Loa (eye worm) hypothetical protein 0.0062 0.0617 0.0978
Loa Loa (eye worm) norepinephrine transporter 0.0203 0.2329 0.3721
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0062 0.0617 0.093
Echinococcus multilocularis sex peptide receptor 0.0062 0.0617 0.0661
Echinococcus multilocularis rhodopsin orphan GPCR 0.0062 0.0617 0.0661
Leishmania major cytochrome P450 reductase, putative 0.0025 0.0162 0.1029
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.0044 0.0102
Onchocerca volvulus 0.0062 0.0617 0.2507
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0062 0.0617 0.0661
Echinococcus multilocularis g protein coupled receptor 0.0062 0.0617 0.0661
Entamoeba histolytica acyl-coA synthetase, putative 0.0051 0.0481 0.4678
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0062 0.0617 0.0611

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5733 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.