Detailed information for compound 1338968

Basic information

Technical information
  • TDR Targets ID: 1338968
  • Name: [2-[(1,1-dioxothiolan-3-yl)-ethylamino]-2-oxo ethyl] 3,5-dimethyl-1-phenylpyrazole-4-carbox ylate
  • MW: 419.495 | Formula: C20H25N3O5S
  • H donors: 0 H acceptors: 5 LogP: 2.01 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C1CCS(=O)(=O)C1)C(=O)COC(=O)c1c(C)nn(c1C)c1ccccc1
  • InChi: 1S/C20H25N3O5S/c1-4-22(17-10-11-29(26,27)13-17)18(24)12-28-20(25)19-14(2)21-23(15(19)3)16-8-6-5-7-9-16/h5-9,17H,4,10-13H2,1-3H3
  • InChiKey: RBYVDIWECBUMFS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-[(1,1-dioxothiolan-3-yl)-ethyl-amino]-2-oxo-ethyl] 3,5-dimethyl-1-phenyl-pyrazole-4-carboxylate
  • 3,5-dimethyl-1-phenyl-4-pyrazolecarboxylic acid [2-[(1,1-dioxo-3-thiolanyl)-ethylamino]-2-oxoethyl] ester
  • 3,5-dimethyl-1-phenyl-pyrazole-4-carboxylic acid [2-[(1,1-diketothiolan-3-yl)-ethyl-amino]-2-keto-ethyl] ester
  • MLS000516816
  • SMR000342958
  • T5286978

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0051
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0083 0.0136
Schistosoma mansoni hypothetical protein 0.0417 0.2563 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0049 0.159
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0133 0.0774 0.0735
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.121 0.6426
Schistosoma mansoni hypothetical protein 0.0017 0.0041 0.0161
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.0265 1
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0083 0.2905
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0049 0.0218
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.041 0.2183
Loa Loa (eye worm) hypothetical protein 0.0075 0.041 0.2183
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.121 0.6426
Schistosoma mansoni lipoxygenase 0.0098 0.0555 0.2167
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0326 0.1272
Toxoplasma gondii exonuclease III APE 0.0023 0.0078 0.1812
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0031 0.0133 0.4822
Toxoplasma gondii thioredoxin reductase 0.0052 0.0265 0.6705
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.0392 0.1528
Brugia malayi glutathione reductase 0.0052 0.0265 0.1413
Trichomonas vaginalis glucosylceramidase, putative 0.0308 0.1879 1
Trichomonas vaginalis replication factor C large subunit, putative 0.0012 0.001 0.0006
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0392 0.0383
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0078 1
Loa Loa (eye worm) hypothetical protein 0.0154 0.0906 0.482
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0072 0.0392 0.1147
Schistosoma mansoni ap endonuclease 0.0023 0.0078 0.0304
Plasmodium falciparum flap endonuclease 1 0.0031 0.0133 0.4846
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0078 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.0265 0.0777
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0017 0.0041 0.0032
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0206 0.7664
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0031 0.012
Brugia malayi Cytochrome P450 family protein 0.0017 0.0041 0.0219
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0049 0.023
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.0265 0.1413
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0051
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0049 0.155
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0107 0.3821
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0078 0.0127
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0133 0.0774 0.0735
Schistosoma mansoni cpg binding protein 0.0029 0.0119 0.0465
Trichomonas vaginalis esterase, putative 0.0043 0.0206 0.1055
Toxoplasma gondii aldehyde dehydrogenase 0.0072 0.0392 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0206 0.0196
Schistosoma mansoni hypothetical protein 0.0012 0.0008 0.0033
Leishmania major hypothetical protein, conserved 0.0043 0.0206 0.4692
Onchocerca volvulus 0.0043 0.0206 0.1699
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0078 0.0414
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0206 0.1055
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0078 0.1027
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0031 0.0133 0.3249
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0017 0.0041 0.0032
Trichomonas vaginalis flap endonuclease-1, putative 0.0031 0.0133 0.0666
Loa Loa (eye worm) hypothetical protein 0.0027 0.0107 0.0567
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0279 0.1088
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0049 0.155
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.0265 0.0434
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0049 0.1066
Echinococcus granulosus nibrin 0.0012 0.001 0.0028
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.005 0.0224
Brugia malayi SET domain containing protein 0.0012 0.0012 0.0066
Onchocerca volvulus 0.0029 0.0119 0.0985
Echinococcus granulosus replication factor c subunit 1 0.0012 0.001 0.0028
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0206 0.0165
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.0392 0.1528
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.001 0.0006
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0031 0.012
Onchocerca volvulus 0.0058 0.0302 0.2495
Loa Loa (eye worm) hypothetical protein 0.0024 0.0083 0.0442
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0049 0.0008
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0008 0.0025
Brugia malayi beta-lactamase family protein 0.0043 0.0206 0.1095
Schistosoma mansoni cpg binding protein 0.0031 0.013 0.0506
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0206 0.0802
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0206 0.0165
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0045
Echinococcus multilocularis nibrin 0.0012 0.001 0.0016
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0017 0.0041 0.1235
Giardia lamblia Flap structure-specific endonuclease 0.0031 0.0133 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0206 0.1055
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0209 0.0341
Loa Loa (eye worm) CYP4Cod1 0.0017 0.0041 0.0219
Trichomonas vaginalis glucosylceramidase, putative 0.0213 0.1279 0.6793
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.001 0.0032
Echinococcus granulosus chromobox protein 2 0.0012 0.0008 0.0025
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0392 0.0383
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0049 0.159
Plasmodium falciparum replication factor C subunit 1, putative 0.0012 0.001 0.0047
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.6111 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0019 0.0055
Plasmodium falciparum glutathione reductase 0.0052 0.0265 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0083 0.0442
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0107 0.3791
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0206 0.1059
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.005 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.001 0.0006
Mycobacterium tuberculosis Conserved protein 0.0043 0.0206 0.0165
Onchocerca volvulus 0.0031 0.0133 0.1096
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0049 0.155
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0187 0.0956
Onchocerca volvulus 0.0012 0.0008 0.0069
Schistosoma mansoni hypothetical protein 0.0049 0.0245 0.0955
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0078 0.2668
Schistosoma mansoni hypothetical protein 0.0346 0.212 0.8271
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0049 0.023
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0017 0.0041 0.0032
Brugia malayi Cytochrome P450 family protein 0.0017 0.0041 0.0219
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0017 0.0041 0.0032
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0041 0.0219
Brugia malayi Protein cec-1. 0.0012 0.0008 0.0045
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0206 0.0337
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.012 0.0689 0.0651
Loa Loa (eye worm) cytochrome P450 family protein 0.0062 0.0329 0.1748
Schistosoma mansoni hypothetical protein 0.0049 0.0245 0.0955
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.012 0.0689 0.0651
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0012 0.0034
Leishmania major trypanothione reductase 0.0052 0.0265 0.6396
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0008 0.0033
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0049 0.0144
Loa Loa (eye worm) hypothetical protein 0.0043 0.0206 0.1095
Schistosoma mansoni chromobox protein 0.0012 0.0008 0.0033
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0049 0.023
Echinococcus multilocularis chromobox protein 1 0.0071 0.0385 0.0631
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0206 0.7664
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0017 0.0041 0.0032
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0275 0.1667 0.1632
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0019 0.01
Schistosoma mansoni hypothetical protein 0.0043 0.0209 0.0814
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0051
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0078 0.0228
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0017 0.0041 0.0032
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0206 0.1055
Entamoeba histolytica hypothetical protein 0.0043 0.0209 0.2962
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0012 0.001 0.0032
Brugia malayi Thioredoxin reductase 0.0052 0.0265 0.1413
Echinococcus granulosus dnaJ subfamily B 0.0417 0.2563 0.7503
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.005 0.0224
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.005 0.0224
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0256 0.0751
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0019 0.0074
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1596 1 1
Schistosoma mansoni hypothetical protein 0.0035 0.0155 0.0604
Onchocerca volvulus 0.0012 0.0012 0.0103
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0008 0.0045
Brugia malayi hypothetical protein 0.0012 0.001 0.0051
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0078 0.2702
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0017 0.0041 0.0032
Plasmodium falciparum thioredoxin reductase 0.0018 0.0049 0.159
Echinococcus multilocularis neuropeptide s receptor 0.0552 0.3416 0.559
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0155 0.0453
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0008 0.0014
Echinococcus granulosus Chromo domain 0.0012 0.0008 0.0025
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.121 0.6426
Echinococcus granulosus RUN 0.0024 0.0083 0.0243
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0206 0.1095
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.001 0.0037
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.012 0.0689 0.068
Brugia malayi hypothetical protein 0.0012 0.0008 0.0045
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0279 0.1485
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0049 0.004
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0017 0.0041 0.0032
Trichomonas vaginalis glucosylceramidase, putative 0.0308 0.1879 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0078 0.5533
Loa Loa (eye worm) hypothetical protein 0.0062 0.0329 0.175
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0017 0.0041 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0114 0.0562
Mycobacterium tuberculosis Putative ferredoxin reductase 0.012 0.0689 0.0651
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0017 0.0041 0.0032
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0045
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0187 0.1547
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0256 0.1326
Onchocerca volvulus 0.0043 0.0206 0.1699
Brugia malayi hypothetical protein 0.0286 0.1736 0.9237
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0045
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0685 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0279 0.1485
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0083 0.2905
Trichomonas vaginalis glucosylceramidase, putative 0.0308 0.1879 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0279 0.1088
Loa Loa (eye worm) hypothetical protein 0.004 0.0187 0.0997
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0049 0.0262
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0049 0.159
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0017 0.0041 0.0032
Loa Loa (eye worm) hypothetical protein 0.0043 0.0206 0.1095
Mycobacterium tuberculosis Conserved protein 0.0043 0.0206 0.0165
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0107 0.3791
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0049 0.159
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.005 0.0224
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0049 0.155
Onchocerca volvulus Glucosylceramidase homolog 0.0202 0.121 1
Treponema pallidum NADH oxidase 0.0018 0.0049 0.581
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0012 0.0012 0.0048
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0049 0.155
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0072 0.0392 0.0352
Schistosoma mansoni hypothetical protein 0.0346 0.212 0.8271
Entamoeba histolytica hypothetical protein 0.0043 0.0209 0.2962
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0187 0.0956
Schistosoma mansoni flap endonuclease-1 0.0028 0.0114 0.0444
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0078 0.0068
Loa Loa (eye worm) hypothetical protein 0.0286 0.1736 0.9237
Schistosoma mansoni loxhd1 0.0024 0.0083 0.0324
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.011 0.063 0.3354
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0083 0.0243
Brugia malayi CXXC zinc finger family protein 0.0029 0.0119 0.0634
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1736 0.5081
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0206 0.0602
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0256 0.042
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0045
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0028 0.0104
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0045
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0685 0.112
Loa Loa (eye worm) hypothetical protein 0.0043 0.0206 0.1095
Brugia malayi hypothetical protein 0.0024 0.0083 0.0442
Mycobacterium tuberculosis Probable oxidoreductase 0.0133 0.0774 0.0735
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0017 0.0041 0.0032
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0696 0.2716
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0049 0.004
Loa Loa (eye worm) transcription factor SMAD2 0.0143 0.0834 0.4436
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0107 0.3791
Loa Loa (eye worm) helicase 0.0012 0.0008 0.0045
Schistosoma mansoni hypothetical protein 0.0049 0.0245 0.0955
Trichomonas vaginalis glucosylceramidase, putative 0.0213 0.1279 0.6793
Schistosoma mansoni topbp1 0.0012 0.001 0.0037
Echinococcus granulosus Chromobox protein 3 0.0012 0.0008 0.0025
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0008 0.0045
Echinococcus granulosus cytochrome P450 2K1 0.0017 0.0041 0.0121
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0083 0.0442
Loa Loa (eye worm) hypothetical protein 0.0043 0.0206 0.1095
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0031 0.0133 0.2618
Brugia malayi hypothetical protein 0.0043 0.0209 0.111
Loa Loa (eye worm) hypothetical protein 0.0035 0.0155 0.0823
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0017 0.0041 0.0032
Echinococcus multilocularis expressed conserved protein 0.0112 0.0639 0.1046
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0049 0.155
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0083 0.0243
Brugia malayi chromobox protein homolog 3 0.004 0.0187 0.0997
Mycobacterium leprae putative cytochrome p450 0.0017 0.0041 0.0032
Mycobacterium ulcerans lipase LipD 0.0043 0.0206 0.0196
Brugia malayi hypothetical protein 0.0012 0.001 0.0051
Onchocerca volvulus 0.0043 0.0206 0.1699
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0012 0.001 0.0018
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0051
Echinococcus granulosus chromobox protein 1 0.0071 0.0385 0.1128
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0107 0.2562
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0078 0.2702
Brugia malayi Calcitonin receptor-like protein seb-1 0.011 0.063 0.3354
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0083 0.0243
Loa Loa (eye worm) hypothetical protein 0.011 0.063 0.3354
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0012 0.001 0.0051
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0008 0.0033
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0209 0.0814
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0206 0.0165
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0017 0.0041 0.0032
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0141 0.0823 0.2408
Mycobacterium ulcerans transcriptional regulator 0.1596 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.0552 0.3416 0.559
Plasmodium falciparum glutathione reductase 0.0018 0.0049 0.159
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0049 0.155
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0008 0.0014
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0031 0.0133 0.4822
Schistosoma mansoni chromobox protein 0.0071 0.0385 0.1504
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.001 0.0006
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0008 0.0033
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0078 0.1046
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0206 0.1055
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0078 0.2668
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0206 0.0165
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.005 0.0224
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0155 0.0253
Echinococcus granulosus geminin 0.0346 0.212 0.6205
Echinococcus multilocularis cpg binding protein 0.0031 0.013 0.0212
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0279 0.0457
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0284 0.7196
Trichomonas vaginalis glucosylceramidase, putative 0.0308 0.1879 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0083 0.0136
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0041 0.1235
Mycobacterium tuberculosis Conserved protein 0.0043 0.0206 0.0165
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.012 0.0689 0.0651
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0008 0.0045
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0133 0.0774 0.0765
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.001 0.0006
Echinococcus multilocularis geminin 0.0346 0.212 0.3469
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0049 0.581
Schistosoma mansoni patched 1 0.0051 0.0256 0.1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0302 0.1607
Loa Loa (eye worm) MH2 domain-containing protein 0.0143 0.0834 0.4436
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0107 0.3821
Brugia malayi CHE-14 protein 0.0051 0.0256 0.1365
Plasmodium vivax glutathione reductase, putative 0.0052 0.0265 1
Schistosoma mansoni hypothetical protein 0.0012 0.0012 0.0046
Echinococcus multilocularis protein dispatched 1 0.0058 0.0302 0.0494
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0049 0.004
Entamoeba histolytica hypothetical protein 0.0043 0.0209 0.2962
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0078 0.0037
Mycobacterium tuberculosis Probable dehydrogenase 0.012 0.0689 0.0651
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0049 0.1066
Loa Loa (eye worm) cytochrome P450 0.0017 0.0041 0.0219
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0385 0.2051
Plasmodium vivax replication factor C subunit 1, putative 0.0012 0.001 0.0047
Echinococcus multilocularis Chromo domain 0.0012 0.0008 0.0014
Brugia malayi DKFZp564C0469 protein 0.0012 0.001 0.0051
Brugia malayi hypothetical protein 0.0018 0.0046 0.0243
Schistosoma mansoni hypothetical protein 0.0035 0.0155 0.0604
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0206 0.0196
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0049 0.155
Brugia malayi CHD4 protein 0.0013 0.0019 0.0101
Schistosoma mansoni hypothetical protein 0.0035 0.0155 0.0604
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0078 0.0371
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0385 0.2015
Echinococcus multilocularis RUN 0.0024 0.0083 0.0136
Schistosoma mansoni lipoxygenase 0.0141 0.0823 0.3209
Schistosoma mansoni rab6-interacting 0.0024 0.0083 0.0324
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.121 0.6426
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0017 0.0041 0.1235
Entamoeba histolytica Flap nuclease, putative 0.0031 0.0133 0.1842
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0041 0.0219
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0078 0.2668
Onchocerca volvulus 0.0024 0.0083 0.0686
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.005 0.0224
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.005 0.0224
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.121 0.6426
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1596 1 1
Brugia malayi beta-lactamase family protein 0.0043 0.0206 0.1095
Schistosoma mansoni hypothetical protein 0.0024 0.0083 0.0324
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0083 0.0136
Mycobacterium tuberculosis Probable reductase 0.012 0.0689 0.0651
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0017 0.0041 0.0032
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0209 0.0611
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0385 0.2015
Schistosoma mansoni chromobox protein 0.0071 0.0385 0.1504
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0279 0.0817
Trypanosoma brucei trypanothione reductase 0.0052 0.0265 1
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0155 0.0823
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0685 0.2004
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.121 0.6426
Echinococcus multilocularis dnaJ subfamily B 0.0417 0.2563 0.4194
Schistosoma mansoni chromobox protein 0.0012 0.0008 0.0033
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0049 0.155
Onchocerca volvulus 0.0012 0.001 0.0079
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0049 0.155
Brugia malayi hypothetical protein 0.0154 0.0906 0.482
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0012 0.0019
Mycobacterium leprae Conserved hypothetical protein 0.0017 0.0041 0.0032
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0017 0.0041 0.0032
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0206 0.7675
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0041 0.1235
Brugia malayi Heterochromatin protein 1 0.0071 0.0385 0.2051
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0685 0.3643
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.001 0.0016
Brugia malayi Cytochrome P450 family protein 0.0017 0.0041 0.0219
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0049 0.023
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0019 0.01
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.001 0.0006
Brugia malayi topoisomerase 0.0012 0.001 0.0051
Schistosoma mansoni hypothetical protein 0.0075 0.041 0.16
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.001 0.0006
Plasmodium falciparum thioredoxin reductase 0.0052 0.0265 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0206 0.0165
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0206 0.1095
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0017 0.0041 0.0032
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0265 1
Onchocerca volvulus 0.0012 0.0008 0.0069
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0041 0.1235
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0141 0.0823 0.1346
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0155 0.0823
Loa Loa (eye worm) hypothetical protein 0.0043 0.0206 0.1095
Mycobacterium ulcerans TetR family transcriptional regulator 0.1596 1 1
Echinococcus multilocularis GPCR, family 2 0.0035 0.0155 0.0253
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0017 0.0041 0.0032
Brugia malayi MH2 domain containing protein 0.0143 0.0834 0.4436
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0019 0.0101
Schistosoma mansoni hypothetical protein 0.0058 0.0302 0.1178
Brugia malayi hypothetical protein 0.0027 0.0107 0.0567
Trichomonas vaginalis glucosylceramidase, putative 0.0308 0.1879 1
Echinococcus multilocularis protein patched 0.0051 0.0256 0.042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0279 0.1088
Schistosoma mansoni polycystin 1-related 0.0024 0.0083 0.0324
Leishmania major hypothetical protein, conserved 0.0027 0.0107 0.1866
Mycobacterium leprae Probable lipase LipE 0.0043 0.0206 0.0196
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0049 0.155
Loa Loa (eye worm) hypothetical protein 0.0031 0.0133 0.0706
Trypanosoma brucei cytochrome P450, putative 0.0017 0.0041 0.1235
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0206 0.0196
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0256 0.0751
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0017 0.0041 0.0032
Echinococcus multilocularis flap endonuclease 1 0.0031 0.0133 0.0218
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0107 0.3821
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0049 0.0218
Schistosoma mansoni hypothetical protein 0.0035 0.0155 0.0604
Entamoeba histolytica hypothetical protein 0.0012 0.001 0.0018
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0045
Loa Loa (eye worm) glutathione reductase 0.0052 0.0265 0.1413
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0206 0.7664
Schistosoma mansoni survival motor neuron protein 0.0058 0.0302 0.1178
Onchocerca volvulus 0.0024 0.0083 0.0686
Schistosoma mansoni rab6-interacting 0.0024 0.0083 0.0324
Echinococcus granulosus flap endonuclease 1 0.0031 0.0133 0.0389
Toxoplasma gondii ABC1 family protein 0.0043 0.0206 0.5146
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0049 0.0081
Brugia malayi hypothetical protein 0.0024 0.0083 0.0442
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0051
Brugia malayi Doublecortin family protein 0.0024 0.0083 0.0442
Echinococcus granulosus neuropeptide s receptor 0.0552 0.3416 1
Onchocerca volvulus 0.0154 0.0906 0.7483
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0155 0.0253
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0049 0.0192
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0072 0.0392 0.0641
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0078 0.0371
Loa Loa (eye worm) hypothetical protein 0.0051 0.0256 0.1365
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1736 0.284
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0049 0.155
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0041 0.1235
Mycobacterium ulcerans beta-lactamase 0.0043 0.0206 0.0196
Brugia malayi Pax transcription activation domain interacting protein 0.0012 0.001 0.0051
Entamoeba histolytica hypothetical protein 0.0043 0.0209 0.2962
Schistosoma mansoni cpg binding protein 0.0031 0.013 0.0506
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0019 0.0031
Plasmodium vivax flap endonuclease 1, putative 0.0031 0.0133 0.4846
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.001 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.001 0.0006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0279 0.0817
Mycobacterium ulcerans hypothetical protein 0.0043 0.0206 0.0196
Echinococcus granulosus cpg binding protein 0.0031 0.013 0.038
Loa Loa (eye worm) pigment dispersing factor receptor c 0.011 0.063 0.3354
Echinococcus multilocularis chromobox protein 2 0.0012 0.0008 0.0014
Schistosoma mansoni hypothetical protein 0.0049 0.0245 0.0955
Echinococcus granulosus expressed conserved protein 0.0112 0.0639 0.187
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1006 0.2946
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0308 0.1879 1
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0017 0.0041 0.0032
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0008 0.0045
Loa Loa (eye worm) hypothetical protein 0.0119 0.0685 0.3643
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0206 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0114 0.0562
Schistosoma mansoni DNA ligase IV 0.0012 0.001 0.0037
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0206 0.0165
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0155 0.0823
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0119 0.0634
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0049 1
Echinococcus granulosus GPCR family 2 0.0035 0.0155 0.0453
Brugia malayi Flap endonuclease-1 0.0031 0.0133 0.0708
Echinococcus granulosus chromobox protein 1 0.0071 0.0385 0.1128
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0049 0.581
Loa Loa (eye worm) hypothetical protein 0.0043 0.0206 0.1095
Echinococcus multilocularis chromobox protein 1 0.0071 0.0385 0.0631
Trichomonas vaginalis glucosylceramidase, putative 0.0308 0.1879 1
Echinococcus granulosus neuropeptide receptor A26 0.0552 0.3416 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0072 0.0392 0.0383
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.001 0.0006
Brugia malayi beta-lactamase 0.0043 0.0206 0.1095
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0045
Brugia malayi Cytochrome P450 family protein 0.0062 0.0329 0.1748
Loa Loa (eye worm) beta-lactamase 0.0043 0.0206 0.1095
Brugia malayi cytochrome P450 0.0017 0.0041 0.0219
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0206 0.1055
Schistosoma mansoni cytochrome P450 0.0017 0.0041 0.0161
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0072 0.0392 1
Schistosoma mansoni ap endonuclease 0.0023 0.0078 0.0304
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1006 0.1647
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0155 0.0453
Loa Loa (eye worm) flap endonuclease-1 0.0031 0.0133 0.0708
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0206 0.1706
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0078 0.0414
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0049 0.155
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0206 0.1059
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.0265 0.0225
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0206 0.0802
Schistosoma mansoni topbp1 0.0012 0.001 0.0037
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0049 0.3215
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0279 0.0457
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0308 0.1879 1
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.121 0.6426
Loa Loa (eye worm) hypothetical protein 0.0012 0.001 0.0051
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0256 0.1365
Toxoplasma gondii cytochrome p450 superfamily protein 0.0017 0.0041 0.0856
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0017 0.0041 0.0032
Echinococcus multilocularis 0.0017 0.0041 0.0067

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 18.3489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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