Detailed information for compound 134526

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 383.524 | Formula: C24H33NO3
  • H donors: 2 H acceptors: 3 LogP: 4.51 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cc1ccccc1)N[C@@H]1[C@@H](C/C=C/CCCC(=O)O)C[C@H]2C[C@@H]1C2(C)C
  • InChi: 1S/C24H33NO3/c1-24(2)19-15-18(12-8-3-4-9-13-22(27)28)23(20(24)16-19)25-21(26)14-17-10-6-5-7-11-17/h3,5-8,10-11,18-20,23H,4,9,12-16H2,1-2H3,(H,25,26)(H,27,28)/b8-3+/t18-,19-,20-,23+/m0/s1
  • InChiKey: VCQQGSGCITTYRX-ZBHWKDLPSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens prostaglandin D2 receptor (DP) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis rhodopsin orphan GPCR prostaglandin D2 receptor (DP) 359 aa 312 aa 23.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0023 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Brugia malayi beta-lactamase family protein 0.0076 0.0431 0.0431
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0037 0.0163 0.0737
Onchocerca volvulus 0.0031 0.0123 0.0353
Schistosoma mansoni hypothetical protein 0.0167 0.105 0.105
Echinococcus granulosus biogenic amine 5HT receptor 0.0015 0.001 0.001
Toxoplasma gondii tRNA ligases class I (M) protein 0.0023 0.0067 0.0274
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Echinococcus multilocularis g protein coupled receptor 0.0015 0.001 0.001
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.001 0.001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0236 0.1528 0.1528
Trichomonas vaginalis ran, putative 0.0021 0.0053 0.0651
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.002 0.0019
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0255 0.0255
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.1474 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0033 0.0349
Echinococcus multilocularis sex peptide receptor 0.0015 0.001 0.001
Loa Loa (eye worm) pax transcription factor protein 2 0.0481 0.3201 0.32
Loa Loa (eye worm) beta-lactamase 0.0076 0.0431 0.0431
Loa Loa (eye worm) G-protein coupled receptor 0.0015 0.001 0.001
Brugia malayi hypothetical protein 0.0015 0.001 0.001
Schistosoma mansoni zinc finger protein 0.0044 0.021 0.021
Schistosoma mansoni growth hormone secretagogue receptor 0.0015 0.001 0.001
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0053 0.0167
Leishmania major diacylglycerol acyltransferase, putative 0.0037 0.0163 0.0737
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0148 0.0148
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0394 0.5768
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0261 0.1697 0.1697
Schistosoma mansoni neuropeptide receptor 0.0015 0.001 0.001
Brugia malayi Serotonin receptor 0.0015 0.001 0.001
Trypanosoma cruzi GUP1, putative 0.0044 0.021 0.0986
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0436 0.0436
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0297 0.1942 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0035 0.0034
Brugia malayi diacylglycerol acyltransferase family protein 0.0166 0.105 0.1049
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0044 0.021 0.021
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0436 0.2479
Entamoeba histolytica hypothetical protein 0.0035 0.0148 0.6476
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0167 0.105 0.105
Onchocerca volvulus 0.0027 0.0092 0.0255
Loa Loa (eye worm) neuropeptide F receptor 0.0015 0.001 0.001
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0023 0.0067 0.0067
Onchocerca volvulus 0.0076 0.0431 0.1319
Echinococcus granulosus g protein coupled receptor 0.0015 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Echinococcus multilocularis neuropeptide Y receptor 0.0015 0.001 0.001
Trypanosoma cruzi GUP1, putative 0.0044 0.021 0.0986
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Leishmania major hypothetical protein, conserved 0.0044 0.021 0.0986
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0261 0.1697 0.1697
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0872 0.4429
Schistosoma mansoni histamine h1 receptor 0.0015 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Echinococcus multilocularis zinc finger transcription factor gli2 0.0299 0.1959 0.1959
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0015 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0015 0.001 0.001
Echinococcus multilocularis methionine tRNA synthetase 0.006 0.0321 0.032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0015 0.001 0.001
Echinococcus granulosus tachykinin peptides receptor 99D 0.0015 0.001 0.001
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.006 0.0321 0.3643
Mycobacterium tuberculosis Conserved protein 0.0076 0.0431 0.1275
Plasmodium falciparum importin beta, putative 0.0028 0.0104 0.0497
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0676 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0033 0.0349
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0067 0.0274
Brugia malayi beta-lactamase 0.0076 0.0431 0.0431
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0015 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0016 0.002 0.002
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.006 0.0321 0.156
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0037 0.0163 0.0737
Brugia malayi RE15519p 0.0015 0.001 0.001
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0053 0.1069
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0033 0.0349
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0015 0.001 0.001
Echinococcus granulosus neuropeptide s receptor 0.0015 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0028 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0223 0.1436 0.1436
Brugia malayi G protein-coupled receptor 0.0015 0.001 0.001
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0261 0.1697 0.1697
Entamoeba histolytica hypothetical protein, conserved 0.0044 0.021 1
Echinococcus multilocularis sterol O acyltransferase 1 0.0044 0.021 0.021
Mycobacterium ulcerans lipase LipD 0.0076 0.0431 0.4272
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.021 0.3012
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0053 0.0191
Echinococcus granulosus chromobox protein 1 0.0071 0.0394 0.0394
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0015 0.001 0.001
Onchocerca volvulus 0.0076 0.0431 0.1319
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0676 1
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0676 1
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.1501 0.1501
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0102 0.0102
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0368 0.0368
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0196 0.0911
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.0431 0.4272
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0044 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0119 0.0728 0.0728
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.0721 0.2176
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.1942 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.1982 0.1981
Leishmania major diacylglycerol acyltransferase, putative 0.0037 0.0163 0.0737
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0044 0.021 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.0728 0.0728
Schistosoma mansoni hypothetical protein 0.0035 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.0721 0.2176
Schistosoma mansoni gabp alpha 0.0075 0.0422 0.0422
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0436 0.0436
Brugia malayi Dopamine receptor protein 1 0.0015 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Entamoeba histolytica vacuolar protein sorting 26 0.0044 0.021 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0015 0.001 0.001
Mycobacterium ulcerans hypothetical protein 0.0076 0.0431 0.4272
Leishmania major glycerol uptake protein, putative 0.0044 0.021 0.0986
Echinococcus granulosus 7tm_1 domain containing protein 0.0015 0.001 0.001
Loa Loa (eye worm) G-protein coupled receptor 0.0015 0.001 0.001
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0196 0.0911
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0436 0.2479
Schistosoma mansoni neuropeptide F-like receptor 0.0015 0.001 0.001
Brugia malayi Thioredoxin reductase 0.0047 0.023 0.023
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.001 0.001
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.023 0.0649
Trypanosoma cruzi glycerol uptake protein, putative 0.0044 0.021 0.0986
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0377 0.5516
Brugia malayi hypothetical protein 0.0015 0.001 0.001
Loa Loa (eye worm) neuropeptide F receptor 0.0015 0.001 0.001
Brugia malayi TAR-binding protein 0.0067 0.0368 0.0368
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.0431 0.1275
Schistosoma mansoni neuropeptide receptor 0.0015 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0303 0.1982 0.1982
Echinococcus granulosus neuropeptide receptor A26 0.0015 0.001 0.001
Mycobacterium tuberculosis Conserved protein 0.0076 0.0431 0.1275
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.001 0.001
Schistosoma mansoni amine GPCR 0.0015 0.001 0.001
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0015 0.001 0.001
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0015 0.001 0.001
Loa Loa (eye worm) hhat protein 0.0044 0.021 0.021
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.0721 0.2176
Schistosoma mansoni ran 0.0021 0.0053 0.0053
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0486 0.3237 1
Schistosoma mansoni biogenic amine receptor 0.0015 0.001 0.001
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0035 0.0072
Schistosoma mansoni opsin-like receptor 0.0015 0.001 0.001
Echinococcus granulosus somatostatin receptor 0.0015 0.001 0.001
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0091 0.0421
Schistosoma mansoni survival motor neuron protein 0.0047 0.0235 0.0235
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0007 0.0007
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0053 0.0053
Brugia malayi CXXC zinc finger family protein 0.0028 0.0102 0.0102
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.001 0.001
Echinococcus multilocularis leucyl tRNA synthetase 0.0023 0.0067 0.0067
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0102 0.1391
Echinococcus multilocularis allatostatin A receptor 0.0015 0.001 0.001
Schistosoma mansoni intermediate filament proteins 0.0027 0.0092 0.0092
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0075 0.0422 0.0421
Echinococcus multilocularis serotonin receptor 0.0015 0.001 0.001
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.0431 0.1275
Schistosoma mansoni amine GPCR 0.0015 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0044 0.021 0.021
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0166 0.105 0.5354
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0431 0.6317
Echinococcus multilocularis geminin 0.0167 0.105 0.105
Brugia malayi hypothetical protein 0.0015 0.001 0.001
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0035 0.0034
Brugia malayi Ets-domain containing protein 0.0075 0.0422 0.0421
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.001 0.001
Trypanosoma brucei glycerol uptake protein, putative 0.0044 0.021 0.0986
Schistosoma mansoni cpg binding protein 0.0028 0.0102 0.0102
Schistosoma mansoni biogenic amine (5HT) receptor 0.0015 0.001 0.001
Toxoplasma gondii thioredoxin reductase 0.0047 0.023 0.1246
Brugia malayi Importin beta-1 subunit 0.0028 0.0104 0.0104
Trichomonas vaginalis esterase, putative 0.0076 0.0431 0.6317
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.002 0.0019
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0261 0.1697 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0015 0.001 0.001
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0436 0.2479
Onchocerca volvulus 0.0044 0.021 0.0628
Echinococcus granulosus sterol O acyltransferase 1 0.0044 0.021 0.021
Loa Loa (eye worm) melatonin receptor type 1A 0.0015 0.001 0.001
Brugia malayi follicle stimulating hormone receptor 0.0015 0.001 0.001
Schistosoma mansoni cpg binding protein 0.003 0.0113 0.0113
Loa Loa (eye worm) fli-1 protein 0.0227 0.1463 0.1463
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0368 0.0368
Echinococcus granulosus peptide allatostatin:somatostatin 0.0015 0.001 0.001
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0023 0.0067 0.1827
Onchocerca volvulus Huntingtin homolog 0.0119 0.0728 0.2249
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0021 0.0021
Brugia malayi hypothetical protein 0.0015 0.001 0.001
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.1474 1 1
Onchocerca volvulus 0.0027 0.0092 0.0255
Echinococcus multilocularis g protein coupled receptor 0.0015 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0044 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Echinococcus granulosus tm gpcr rhodopsin 0.0015 0.001 0.001
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0261 0.1697 1
Echinococcus multilocularis neuropeptide receptor A26 0.0015 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Treponema pallidum alginate O-acetylation protein (algI) 0.0044 0.021 0.4562
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0256 0.0256
Brugia malayi Pax transcription factor protein 2 0.0481 0.3201 0.32
Brugia malayi RNA binding protein 0.0067 0.0368 0.0368
Echinococcus granulosus GPCR family 2 0.0016 0.002 0.0019
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.023 0.1246
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0044 0.021 0.021
Schistosoma mansoni neuropeptide receptor 0.0015 0.001 0.001
Brugia malayi hypothetical protein 0.0015 0.001 0.001
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0273 0.1506
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Mycobacterium leprae conserved hypothetical protein 0.0076 0.0431 0.5394
Toxoplasma gondii exonuclease III APE 0.0018 0.0035 0.0083
Schistosoma mansoni hypothetical protein 0.0044 0.021 0.021
Brugia malayi methionyl-tRNA synthetase 0.006 0.0321 0.032
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Toxoplasma gondii dgat2l1-prov protein 0.0166 0.105 0.6138
Leishmania major glycerol uptake protein, putative 0.0044 0.021 0.0986
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0431 0.2134
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.0872 0.4429
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0236 0.1528 0.1528
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0015 0.001 0.001
Schistosoma mansoni chromobox protein 0.0071 0.0394 0.0394
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0436 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0035 0.0043
Echinococcus granulosus cpg binding protein 0.003 0.0113 0.0112
Leishmania major trypanothione reductase 0.0047 0.023 0.1087
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.0431 0.1275
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0037 0.0163 0.0737
Toxoplasma gondii ABC1 family protein 0.0076 0.0431 0.2446
Echinococcus granulosus lamin dm0 0.0027 0.0092 0.0091
Loa Loa (eye worm) hypothetical protein 0.0077 0.0436 0.0436
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0236 0.1528 0.1528
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0368 0.0368
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0044 0.021 0.021
Schistosoma mansoni hypothetical protein 0.0016 0.002 0.002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0236 0.1528 0.1528
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.023 0.023
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.006 0.0321 0.7215
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0044 0.021 0.021
Brugia malayi neuropeptide F receptor 0.0015 0.001 0.001
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0015 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0076 0.0428 0.0428
Brugia malayi Ets-domain containing protein 0.0075 0.0422 0.0421
Brugia malayi putative neuropeptide receptor NPR1 0.0015 0.001 0.001
Brugia malayi hypothetical protein 0.0119 0.0728 0.0728
Echinococcus multilocularis dnaJ subfamily B 0.0399 0.264 0.264
Brugia malayi Zinc finger, C2H2 type family protein 0.0299 0.1959 0.1959
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0676 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.0639 0.1923
Echinococcus granulosus neuropeptide Y receptor 0.0015 0.001 0.001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0033 0.0349
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0015 0.001 0.001
Brugia malayi MBOAT family protein 0.0044 0.021 0.021
Schistosoma mansoni biogenic amine receptor 0.0015 0.001 0.001
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0067 0.0242
Echinococcus granulosus snurportin 1 0.0303 0.1982 0.1981
Trypanosoma brucei trypanothione reductase 0.0047 0.023 0.1087
Echinococcus multilocularis chromobox protein 1 0.0071 0.0394 0.0394
Entamoeba histolytica hypothetical protein 0.0035 0.0148 0.6476
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0256 0.0256
Echinococcus granulosus serotonin receptor 0.0015 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0013 0.0048
Treponema pallidum methionyl-tRNA synthetase 0.0023 0.0067 0.1106
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.002 0.0019
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0023 0.0067 0.0479
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0872 0.4429
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0015 0.001 0.001
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.1474 1 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0015 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0223 0.1436 0.1436
Plasmodium vivax importin-beta 2, putative 0.0028 0.0104 0.0497
Trichomonas vaginalis transmembrane protein nessy, putative 0.0044 0.021 0.3012
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0044 0.021 0.021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.001 0.001
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0196 0.0911
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.001 0.001
Toxoplasma gondii hypothetical protein 0.0044 0.0209 0.1124
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0104 0.0497
Loa Loa (eye worm) tyrosyl-tRNA synthetase 0.0037 0.0164 0.0164
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0431 0.0431
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0436 0.5482
Brugia malayi G-protein coupled receptor 0.0015 0.001 0.001
Echinococcus granulosus g-protein coupled receptor 0.0015 0.001 0.001
Echinococcus multilocularis snurportin 1 0.0303 0.1982 0.1981
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0015 0.001 0.001
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0035 0.0144
Brugia malayi Fli-1 protein 0.0227 0.1463 0.1463
Loa Loa (eye worm) MBOAT family protein 0.0044 0.021 0.021
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0436 1
Echinococcus granulosus zinc finger transcription factor gli2 0.0299 0.1959 0.1959
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0021 0.0021
Echinococcus granulosus o acyltransferase membrane bound domain 0.0044 0.021 0.021
Trypanosoma brucei diacylglycerol acyltransferase, putative 0.0037 0.0163 0.0737
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0148 0.0148
Echinococcus granulosus tm gpcr rhodopsin 0.0015 0.001 0.001
Echinococcus multilocularis lamin dm0 0.0027 0.0092 0.0091
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0015 0.001 0.001
Trypanosoma cruzi glycerol uptake protein, putative 0.0044 0.021 0.0986
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0044 0.021 0.021
Schistosoma mansoni importin beta-1 0.0028 0.0104 0.0104
Schistosoma mansoni lamin 0.0027 0.0092 0.0092
Brugia malayi Melatonin receptor type 1A 0.0015 0.001 0.001
Leishmania major methionyl-tRNA synthetase, putative 0.006 0.0321 0.156
Brugia malayi Serotonin receptor 0.0015 0.001 0.001
Brugia malayi MBOAT family protein 0.0044 0.021 0.021
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0255 0.0728
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0015 0.001 0.001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0015 0.001 0.001
Brugia malayi hypothetical protein 0.0015 0.001 0.001
Schistosoma mansoni amine GPCR 0.0015 0.001 0.001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.001 0.001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0015 0.001 0.001
Brugia malayi hypothetical protein 0.0015 0.001 0.001
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0015 0.001 0.001
Echinococcus multilocularis somatostatin receptor 0.0015 0.001 0.001
Echinococcus granulosus orexin receptor type 2 0.0015 0.001 0.001
Brugia malayi GnHR receptor homolog 0.0015 0.001 0.001
Echinococcus multilocularis fmrfamide receptor 0.0015 0.001 0.001
Echinococcus multilocularis neuropeptides capa receptor 0.0015 0.001 0.001
Echinococcus multilocularis lamin 0.0027 0.0092 0.0091
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0166 0.105 0.5354
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0092 0.0091
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0104 0.0104
Brugia malayi Latrophilin receptor protein 2 0.0016 0.002 0.0019
Echinococcus granulosus sex peptide receptor 0.0015 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0051 0.0256 0.0256
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0021 0.0021
Brugia malayi chromobox protein homolog 3 0.004 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0232 0.1501 0.1501
Brugia malayi G-protein coupled receptor 0.0015 0.001 0.001
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0261 0.1697 0.1697
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0067 0.0869
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.0639 0.1923
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0436 1
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0676 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0431 0.0431
Schistosoma mansoni opsin-like receptor 0.0015 0.001 0.001
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0044 0.021 0.021
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0431 0.6317
Echinococcus granulosus neuropeptide receptor 0.0015 0.001 0.001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0033 0.0349
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0015 0.001 0.001
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0015 0.001 0.001
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0053 0.0053
Brugia malayi Hhat protein 0.0044 0.021 0.021
Schistosoma mansoni hypothetical protein 0.0015 0.001 0.001
Echinococcus granulosus importin subunit beta 1 0.0028 0.0104 0.0104
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0255 0.0728
Schistosoma mansoni hypothetical protein 0.0035 0.0147 0.0147
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0015 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0399 0.264 0.264
Schistosoma mansoni hypothetical protein 0.0015 0.001 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.001 0.001
Toxoplasma gondii diacylglycerol acyltransferase 0.0037 0.0163 0.0845
Loa Loa (eye worm) hypothetical protein 0.0076 0.0431 0.0431
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0148 0.0148
Leishmania major GTP-binding protein, putative 0.0021 0.0053 0.0167
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0015 0.001 0.001
Treponema pallidum leucyl-tRNA synthetase 0.0023 0.0067 0.1106
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0015 0.001 0.001
Schistosoma mansoni neuropeptide receptor 0.0015 0.001 0.001
Schistosoma mansoni sterol O-acyltransferase 1 0.0044 0.021 0.021
Echinococcus multilocularis neuropeptide Y receptor 0.0015 0.001 0.001
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0147 0.0147
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0236 0.1528 0.1528
Echinococcus granulosus intermediate filament protein 0.0027 0.0092 0.0091
Loa Loa (eye worm) MBOAT family protein 0.0044 0.021 0.021
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0015 0.001 0.001
Entamoeba histolytica hypothetical protein 0.0044 0.021 1
Toxoplasma gondii mono- or diacylglycerol acyltransferase 0.0037 0.0163 0.0845
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0431 0.6317
Brugia malayi Heterochromatin protein 1 0.0071 0.0394 0.0394
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.0431 0.2134
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Schistosoma mansoni ap endonuclease 0.0018 0.0035 0.0035
Schistosoma mansoni methionine-tRNA synthetase 0.006 0.0321 0.0321
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0436 1
Mycobacterium ulcerans methionyl-tRNA synthetase 0.006 0.0321 0.3123
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.001 0.001
Brugia malayi larval opioid receptor 0.0015 0.001 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.001 0.001
Loa Loa (eye worm) zinc finger protein 0.0299 0.1959 0.1959
Echinococcus granulosus allatostatin A receptor 0.0015 0.001 0.001
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0044 0.021 0.021
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0053 0.0191
Brugia malayi putative neuropeptide receptor 0.0015 0.001 0.001
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0431 0.6317
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0033 0.0349
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0166 0.105 0.105
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0261 0.1697 1
Onchocerca volvulus 0.0047 0.0235 0.0704
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.021 0.3012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.001 0.001
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0431 0.6317
Schistosoma mansoni amine GPCR 0.0015 0.001 0.001
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0044 0.021 0.021
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.0721 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Echinococcus granulosus neuropeptides capa receptor 0.0015 0.001 0.001
Schistosoma mansoni ran 0.0021 0.0053 0.0053
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.0431 0.1275
Brugia malayi Dopamine receptor 0.0015 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Trichomonas vaginalis porcupine, putative 0.0044 0.021 0.3012
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0044 0.021 0.021
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0317 0.0317
Echinococcus granulosus neuropeptide FF receptor 2 0.0015 0.001 0.001
Echinococcus multilocularis cpg binding protein 0.003 0.0113 0.0112
Trypanosoma brucei diacylglycerol acyltransferase, putative 0.0166 0.105 0.5354
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0091 0.0421
Echinococcus granulosus tm gpcr rhodopsin 0.0015 0.001 0.001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0033 0.0349
Loa Loa (eye worm) hypothetical protein 0.0217 0.1396 0.1396
Echinococcus granulosus o acyltransferase membrane bound domain 0.0044 0.021 0.021
Onchocerca volvulus 0.0076 0.0431 0.1319
Brugia malayi beta-lactamase family protein 0.0076 0.0431 0.0431
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0015 0.001 0.001
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0044 0.021 0.021
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.1501 0.1501
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0035 0.0034
Echinococcus granulosus alpha 13 mannosyl glycoprotein 0.0223 0.1436 0.1436
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0035 0.0072
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0196 0.0911
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0015 0.001 0.001
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.023 0.1087
Plasmodium falciparum thioredoxin reductase 0.0047 0.023 0.1246
Brugia malayi MBOAT family protein 0.0044 0.021 0.021
Trypanosoma cruzi glycerol uptake protein, putative 0.0044 0.021 0.0986
Brugia malayi MBOAT family protein 0.0044 0.021 0.021
Schistosoma mansoni hypothetical protein 0.0016 0.002 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0676 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0092 0.0091
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0067 0.0869
Schistosoma mansoni opsin-like receptor 0.0015 0.001 0.001
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.0431 0.0431
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0255 0.26
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0236 0.1528 0.1528
Brugia malayi hypothetical protein 0.0015 0.001 0.001
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0436 0.2479
Mycobacterium ulcerans beta-lactamase 0.0076 0.0431 0.4272
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0236 0.1528 0.1528
Brugia malayi GNT-I family protein 0.0223 0.1436 0.1436
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.0431 0.0431
Loa Loa (eye worm) hypothetical protein 0.0026 0.0088 0.0088
Echinococcus granulosus g protein coupled receptor 0.0015 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.021 0.3012
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.001 0.001
Onchocerca volvulus Huntingtin homolog 0.0119 0.0728 0.2249
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0035 0.0072
Toxoplasma gondii hypothetical protein 0.0026 0.0091 0.0421
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0044 0.021 0.021
Brugia malayi hypothetical protein 0.0035 0.0148 0.0148
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0053 0.0053
Chlamydia trachomatis methionine--tRNA ligase 0.0023 0.0067 0.1106
Brugia malayi Dopamine receptor protein 2 0.0015 0.001 0.001
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0368 0.0368
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0035 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0181 0.2579
Loa Loa (eye worm) methionyl-tRNA synthetase 0.006 0.0321 0.032
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.0431 0.0431
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0023 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0023 0.0067 0.0067
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0044 0.021 0.021
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0044 0.021 0.021
Brugia malayi AKH receptor 0.0015 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0104 0.0433
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.001 0.001
Echinococcus granulosus hypothetical protein 0.0015 0.001 0.001
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0044 0.021 0.021
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.001 0.001
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.023 0.023
Leishmania major leucyl-tRNA synthetase, putative 0.0023 0.0067 0.0239
Giardia lamblia Methionyl-tRNA synthetase 0.006 0.0321 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0181 0.0181
Echinococcus granulosus o acyltransferase membrane bound domain 0.0044 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0023 0.0067 0.0067
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.0431 0.4272
Schistosoma mansoni diacylglycerol O-acyltransferase 0.0037 0.0163 0.0163
Schistosoma mansoni chromobox protein 0.0071 0.0394 0.0394
Brugia malayi hypothetical protein 0.0015 0.001 0.001
Echinococcus multilocularis neuropeptide s receptor 0.0015 0.001 0.001
Leishmania major hypothetical protein, unknown function,protein, unknown function 0.0037 0.0163 0.0737
Echinococcus multilocularis G-protein coupled receptor, putative 0.0015 0.001 0.001
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0368 0.0368
Echinococcus granulosus neuropeptides capa receptor 0.0015 0.001 0.001
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.0431 0.1275
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.0431 0.1275
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0015 0.001 0.001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0035 0.0072
Brugia malayi diacylglycerol acyltransferase 0.0261 0.1697 0.1697
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0067 0.0869
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0261 0.1697 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0015 0.001 0.001
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0053 0.0167
Leishmania major glycerol uptake protein, putative 0.0044 0.021 0.0986
Echinococcus multilocularis orexin receptor type 2 0.0015 0.001 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0431 0.2134
Echinococcus multilocularis GA binding protein alpha chain 0.0075 0.0422 0.0421
Brugia malayi Tachykinin-like peptides receptor 99D 0.0015 0.001 0.001
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0015 0.001 0.001
Mycobacterium ulcerans hypothetical protein 0.0037 0.0163 0.1476
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Leishmania major importin beta-1 subunit, putative 0.0023 0.0067 0.0242
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0015 0.001 0.001
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0015 0.001 0.001
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0431 0.0431
Brugia malayi protein ZK524.3 0.0023 0.0067 0.0067
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.0639 0.1923
Loa Loa (eye worm) hypothetical protein 0.0064 0.0347 0.0347
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0436 0.0436
Chlamydia trachomatis leucine--tRNA ligase 0.0023 0.0067 0.1106
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Schistosoma mansoni amine GPCR 0.0015 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0031 0.0123 0.0123
Echinococcus granulosus dro:myosuppressin receptor 0.0015 0.001 0.001
Schistosoma mansoni biogenic amine receptor 0.0015 0.001 0.001
Schistosoma mansoni adenoreceptor 0.0015 0.001 0.001
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0202 0.2887
Echinococcus multilocularis musashi 0.0027 0.0092 0.0091
Schistosoma mansoni lamin 0.0027 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Brugia malayi intermediate filament protein 0.0027 0.0092 0.0091
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.006 0.0321 0.0932
Echinococcus multilocularis serotonin receptor 0.0015 0.001 0.001
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0021 0.0171
Echinococcus granulosus alpha 1A adrenergic receptor 0.0015 0.001 0.001
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0431 0.2446
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0044 0.021 1
Schistosoma mansoni hypothetical protein 0.0047 0.0235 0.0235
Schistosoma mansoni neuropeptide f receptor 76f 0.0015 0.001 0.001
Loa Loa (eye worm) hhat protein 0.0044 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0076 0.0431 0.0431
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0436 0.4329
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0015 0.001 0.001
Echinococcus multilocularis g-protein coupled receptor 0.0015 0.001 0.001
Plasmodium vivax methionine--tRNA ligase, putative 0.006 0.0321 0.1789
Entamoeba histolytica hypothetical protein 0.0023 0.0067 0.1863
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0015 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0076 0.0431 0.0431
Loa Loa (eye worm) RNA binding protein 0.0067 0.0368 0.0368
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0091 0.1698
Schistosoma mansoni neuropeptide F-like receptor 0.0015 0.001 0.001
Mycobacterium leprae Probable lipase LipE 0.0076 0.0431 0.5394
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0258 0.1236
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.0431 0.1275
Brugia malayi neuropeptide F receptor 0.0015 0.001 0.001
Schistosoma mansoni ets-related 0.0227 0.1463 0.1463
Echinococcus multilocularis dro:myosuppressin receptor 0.0015 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0076 0.0431 0.0431
Brugia malayi MBOAT family protein 0.0044 0.021 0.021
Echinococcus granulosus neuropeptide Y receptor 0.0015 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0044 0.021 0.021
Entamoeba histolytica Ran family GTPase 0.0021 0.0053 0.1035
Schistosoma mansoni diacylglycerol O-acyltransferase 0.0037 0.0163 0.0163
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.001 0.001
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0015 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0676 1
Brugia malayi hypothetical protein 0.0232 0.1501 0.1501
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0436 0.4329
Leishmania major glycerol uptake protein, putative 0.0044 0.021 0.0986
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0368 0.0368
Echinococcus granulosus fmrfamide receptor 0.0015 0.001 0.001
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0202 0.0602
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0015 0.001 0.001
Echinococcus multilocularis GPCR, family 2 0.0016 0.002 0.0019
Entamoeba histolytica hypothetical protein 0.0035 0.0148 0.6476
Schistosoma mansoni alpha-1 adrenergic receptor 0.0015 0.001 0.001
Echinococcus multilocularis G protein coupled receptor 139 0.0015 0.001 0.001
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0368 0.0368
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0053 0.0167
Echinococcus granulosus GA binding protein alpha chain 0.0075 0.0422 0.0421
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0035 0.0333
Leishmania major mitochondrial DNA polymerase beta 0.0297 0.1942 1
Schistosoma mansoni cpg binding protein 0.003 0.0113 0.0113
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.0639 0.1923
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0037 0.0163 0.0737
Plasmodium falciparum glutathione reductase 0.0047 0.023 0.1246
Toxoplasma gondii methionyl-tRNA synthetase 0.006 0.0321 0.1789
Echinococcus granulosus neuropeptide receptor 0.0015 0.001 0.001
Schistosoma mansoni biogenic amine (5HT) receptor 0.0015 0.001 0.001
Plasmodium vivax glutathione reductase, putative 0.0047 0.023 0.1246
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0235 0.0234
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0035 0.0379
Mycobacterium tuberculosis Conserved protein 0.0076 0.0431 0.1275
Mycobacterium ulcerans hypothetical protein 0.0156 0.0981 1
Brugia malayi glutathione reductase 0.0047 0.023 0.023
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.002 0.0019
Schistosoma mansoni hypothetical protein 0.0016 0.002 0.002
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0035 0.0462
Schistosoma mansoni methionine-tRNA synthetase 0.0023 0.0067 0.0067
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0015 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Trichomonas vaginalis chromobox protein, putative 0.0071 0.0394 0.5768
Brugia malayi sulfakinin receptor protein 0.0015 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Plasmodium falciparum methionine--tRNA ligase, putative 0.0023 0.0067 0.0274
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0104 0.0433
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0102 0.1391
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.001 0.001
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.1942 1
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0035 0.0379
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0181 0.0537
Echinococcus granulosus biogenic amine 5HT receptor 0.0015 0.001 0.001
Brugia malayi hypothetical protein 0.0015 0.001 0.001
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0368 0.0368
Echinococcus multilocularis chromobox protein 1 0.0071 0.0394 0.0394
Echinococcus granulosus G protein coupled receptor 139 0.0015 0.001 0.001
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0092 0.0091
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.001 0.001
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0092 0.0091
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0013 0.0048
Echinococcus multilocularis neuropeptide receptor 0.0015 0.001 0.001
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.006 0.0321 0.156
Echinococcus multilocularis neuropeptides capa receptor 0.0015 0.001 0.001
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0053 0.0191
Brugia malayi RNA, U transporter 1 0.0081 0.0462 0.0462
Loa Loa (eye worm) heterochromatin protein 1 0.0071 0.0394 0.0394
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0015 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0015 0.001 0.001
Echinococcus granulosus rhodopsin orphan GPCR 0.0015 0.001 0.001
Echinococcus granulosus chromobox protein 1 0.0071 0.0394 0.0394
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0044 0.021 0.021
Echinococcus multilocularis neuropeptide FF receptor 2 0.0015 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0181 0.2579
Loa Loa (eye worm) hypothetical protein 0.0035 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Onchocerca volvulus 0.0481 0.3201 1
Brugia malayi methionyl-tRNA synthetase 0.0023 0.0067 0.0067
Brugia malayi G protein-coupled receptor F59B2.13 0.0015 0.001 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0015 0.001 0.001
Mycobacterium tuberculosis Probable reductase 0.0106 0.0639 0.1923
Loa Loa (eye worm) glutathione reductase 0.0047 0.023 0.023
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.006 0.0321 0.4665
Echinococcus granulosus tar DNA binding protein 0.0067 0.0368 0.0368
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0015 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Echinococcus granulosus g protein coupled receptor 0.0015 0.001 0.001
Leishmania major glycerol uptake protein, putative 0.0044 0.021 0.0986
Echinococcus multilocularis neuropeptide receptor 0.0015 0.001 0.001
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.0981 0.2984
Onchocerca volvulus 0.0166 0.105 0.3258
Brugia malayi Glycosylation related protein 12, isoform 0.0076 0.0428 0.0428
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Echinococcus multilocularis g protein coupled receptor 0.0015 0.001 0.001
Loa Loa (eye worm) TYRA-2 protein 0.0015 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0021 0.0171
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Toxoplasma gondii Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase 0.0076 0.0428 0.2428
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0015 0.001 0.001
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0076 0.0431 0.0431
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.002 0.0019
Loa Loa (eye worm) MBOAT family protein 0.0044 0.021 0.021
Brugia malayi Probable ClpP-like protease 0.0077 0.0436 0.0436
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0015 0.001 0.001
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.0431 0.0431
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0368 0.0368
Schistosoma mansoni alpha-13-mannosyl-glycoprotein beta-1 2-n-acetylglucosaminyltransferase 0.0223 0.1436 0.1436
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Echinococcus granulosus geminin 0.0167 0.105 0.105
Onchocerca volvulus 0.0028 0.0102 0.0287
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0236 0.1528 0.1528
Loa Loa (eye worm) hypothetical protein 0.1474 1 1
Plasmodium falciparum methionine--tRNA ligase 0.006 0.0321 0.1789
Trypanosoma brucei glycerol uptake protein, putative 0.0044 0.021 0.0986
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0166 0.105 0.1049
Echinococcus multilocularis alpha 1,3 mannosyl glycoprotein 0.0223 0.1436 0.1436
Toxoplasma gondii hypothetical protein 0.0044 0.021 0.1131
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0236 0.1528 0.1528
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0044 0.021 1
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0044 0.021 0.021
Toxoplasma gondii hypothetical protein 0.0048 0.0238 0.1295
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0202 0.2887
Entamoeba histolytica hypothetical protein 0.0035 0.0148 0.6476
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0256 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.0676 1
Giardia lamblia Leucyl-tRNA synthetase 0.0023 0.0067 0.1532
Echinococcus granulosus 7TM GPCR rhodopsin 0.0015 0.001 0.001
Echinococcus multilocularis fmrfamide receptor 0.0015 0.001 0.001
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.0639 0.8707
Schistosoma mansoni leucyl-tRNA synthetase 0.0023 0.0067 0.0067
Brugia malayi ORL1-like opioid receptor 0.0015 0.001 0.001
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0033 0.0349
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0015 0.001 0.001
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0015 0.001 0.001
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0037 0.0163 0.0163
Schistosoma mansoni ap endonuclease 0.0018 0.0035 0.0035
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0035 0.0083
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0023 0.0067 0.1106
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0035 0.0083
Echinococcus granulosus lamin 0.0027 0.0092 0.0091
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0035 0.0333
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Echinococcus granulosus methionine tRNA synthetase 0.006 0.0321 0.032
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.0639 0.1923
Leishmania major diacylglycerol acyltransferase, putative 0.0166 0.105 0.5354
Onchocerca volvulus 0.0037 0.0164 0.0482
Plasmodium vivax methionine--tRNA ligase, putative 0.0023 0.0067 0.0274
Echinococcus granulosus dnaJ subfamily B 0.0399 0.264 0.264
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Leishmania major hypothetical protein, conserved 0.0076 0.0431 0.2134
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Schistosoma mansoni myosin xvIII 0.0015 0.001 0.001

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 1 uM Concentration required to inhibit the PGD-2 evoked cAMP formation in human platelets ChEMBL. 12773048
IC50 (functional) > 1 uM Concentration required to inhibit the PGD-2 evoked cAMP formation in human platelets ChEMBL. 12773048
IC50 (binding) > 10 uM Prostaglandin D2 receptor antagonist activity, evaluated by inhibition of [3H]-PGD-2 binding to human platelet membranes ChEMBL. 12773048
IC50 (binding) > 10 uM Prostaglandin D2 receptor antagonist activity, evaluated by inhibition of [3H]-PGD-2 binding to human platelet membranes ChEMBL. 12773048

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.