Detailed information for compound 1347207

Basic information

Technical information
  • TDR Targets ID: 1347207
  • Name: 2-[[3-(4-methylphenyl)-4-oxo-[1]benzoxolo[3,2 -d]pyrimidin-2-yl]sulfanyl]acetamide
  • MW: 365.406 | Formula: C19H15N3O3S
  • H donors: 1 H acceptors: 2 LogP: 3.42 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)CSc1nc2c3ccccc3oc2c(=O)n1c1ccc(cc1)C
  • InChi: 1S/C19H15N3O3S/c1-11-6-8-12(9-7-11)22-18(24)17-16(21-19(22)26-10-15(20)23)13-4-2-3-5-14(13)25-17/h2-9H,10H2,1H3,(H2,20,23)
  • InChiKey: DLCDERQKJZBQLF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[3-(4-methylphenyl)-4-oxo-benzofurano[3,2-d]pyrimidin-2-yl]sulfanylacetamide
  • 2-[[3-(4-methylphenyl)-4-oxo-2-benzofurano[3,2-d]pyrimidinyl]thio]acetamide
  • 2-[[4-keto-3-(4-methylphenyl)benzofurano[3,2-d]pyrimidin-2-yl]thio]acetamide
  • 2-[[3-(4-methylphenyl)-4-oxo-[1]benzoxolo[3,2-d]pyrimidin-2-yl]sulfanyl]ethanamide
  • C764-0176
  • NCGC00112684-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAN, member RAS oncogene family No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0391 0.0907
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0296 0.0288
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0391 1
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0391 0.0814
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0726 0.0719
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0296 0.6537
Echinococcus granulosus dnaJ subfamily B 0.0494 0.5333 0.5329
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0391 0.0383
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0391 1
Schistosoma mansoni hypothetical protein 0.0494 0.5333 0.6133
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0391 0.0814
Plasmodium falciparum importin beta, putative 0.0035 0.0296 0.1252
Onchocerca volvulus 0.0043 0.0391 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0234 0.0226
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0163 0.0155
Trichomonas vaginalis ran, putative 0.0026 0.0195 0.4989
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0224 0.3904
Schistosoma mansoni hypothetical protein 0.0372 0.3992 0.4589
Brugia malayi Kinesin motor domain containing protein 0.0119 0.1224 1
Schistosoma mansoni hypothetical protein 0.08 0.869 1
Echinococcus multilocularis snurportin 1 0.0372 0.3992 0.3987
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0391 1
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.5333 0.5329
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0195 0.0302
Schistosoma mansoni hypothetical protein 0.0018 0.0116 0.0125
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0195 0.0302
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0195 0.0302
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0391 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0721 0.0821
Echinococcus granulosus importin subunit beta 1 0.0035 0.0296 0.0288
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0163 0.1694
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.2961 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0454 0.1066
Loa Loa (eye worm) kinesin-like protein KLP2 0.0119 0.1224 0.3011
Brugia malayi Bromodomain containing protein 0.0093 0.0929 0.7476
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0296 0.1252
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0163 0.1694
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0391 0.0814
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0391 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0391 0.0907
Echinococcus multilocularis kinesin family 1 0.0919 1 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0032 0.0023
Brugia malayi beta-lactamase family protein 0.0043 0.0391 0.287
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0391 1
Schistosoma mansoni ap endonuclease 0.0023 0.0163 0.0178
Schistosoma mansoni bromodomain containing protein 0.0078 0.0774 0.0882
Mycobacterium ulcerans hypothetical protein 0.0043 0.0391 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0851 0.2069
Brugia malayi beta-lactamase 0.0043 0.0391 0.287
Brugia malayi beta-lactamase family protein 0.0043 0.0391 0.287
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0726 0.0719
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0391 0.0814
Brugia malayi RNA, U transporter 1 0.0099 0.1 0.8084
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0148 0.0294
Mycobacterium tuberculosis Conserved protein 0.0043 0.0391 0.0814
Schistosoma mansoni ran 0.0026 0.0195 0.0215
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0391 0.2147
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0391 1
Toxoplasma gondii ABC1 family protein 0.0043 0.0391 0.2147
Loa Loa (eye worm) hypothetical protein 0.0043 0.0391 0.0907
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0187 0.0393
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0163 0.0921
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.3992 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0032 0.0023
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0163 0.5
Entamoeba histolytica hypothetical protein 0.0028 0.0224 0.0571
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0195 0.2861
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0391 0.0383
Mycobacterium tuberculosis Conserved protein 0.0043 0.0391 0.0814
Mycobacterium leprae Probable lipase LipE 0.0043 0.0391 0.5
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0195 0.0302
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0163 0.0155
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.039 0.0382
Plasmodium vivax importin-beta 2, putative 0.0035 0.0296 0.1252
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0391 0.0814
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0195 0.0187
Loa Loa (eye worm) hypothetical protein 0.0046 0.0422 0.0986
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0195 0.2861
Schistosoma mansoni cpg binding protein 0.0039 0.0341 0.0384
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0391 0.287
Schistosoma mansoni ap endonuclease 0.0023 0.0163 0.0178
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0163 0.0332
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0224 0.5721
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0163 0.417
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0391 0.0814
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0294 0.0663
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.039 0.0382
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0163 0.1694
Toxoplasma gondii kinesin motor domain-containing protein 0.0119 0.1224 1
Mycobacterium ulcerans lipase LipD 0.0043 0.0391 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0195 0.0413
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0195 0.1195
Brugia malayi Bromodomain containing protein 0.0046 0.0421 0.3131
Loa Loa (eye worm) hypothetical protein 0.0043 0.0391 0.0907
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.014 0.0151
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0391 1
Echinococcus granulosus cpg binding protein 0.0039 0.0341 0.0333
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0391 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.014 0.0132
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0224 0.5721
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0163 0.5
Onchocerca volvulus 0.0043 0.0391 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0391 0.0907
Leishmania major hypothetical protein, conserved 0.0043 0.0391 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0234 0.0226
Schistosoma mansoni kinesin eg-5 0.0119 0.1224 0.14
Echinococcus granulosus snurportin 1 0.0372 0.3992 0.3987
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0234 0.026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0148 0.0161
Loa Loa (eye worm) beta-lactamase 0.0043 0.0391 0.0907
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0391 0.5
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0224 0.5721
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0.0148 0.014
Loa Loa (eye worm) hypothetical protein 0.0035 0.0296 0.0667
Mycobacterium tuberculosis Conserved protein 0.0043 0.0391 0.0814
Trichomonas vaginalis esterase, putative 0.0043 0.0391 1
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0163 0.417
Loa Loa (eye worm) hypothetical protein 0.0021 0.0148 0.0294
Schistosoma mansoni ran 0.0026 0.0195 0.0215
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0391 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.014 0.0151
Echinococcus multilocularis zinc finger protein 0.0026 0.0195 0.0187
Loa Loa (eye worm) hypothetical protein 0.0043 0.0391 0.0907
Brugia malayi Importin beta-1 subunit 0.0035 0.0296 0.2058
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0148 0.0161
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0391 0.0814
Loa Loa (eye worm) hypothetical protein 0.0053 0.0501 0.1184
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0195 0.0187
Leishmania major importin beta-1 subunit, putative 0.0028 0.0224 0.3904
Entamoeba histolytica kinesin, putative 0.0119 0.1224 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0163 0.1694
Schistosoma mansoni zinc finger protein 0.0018 0.0116 0.0125
Entamoeba histolytica Ran family GTPase 0.0026 0.0195 0.0302
Plasmodium falciparum kinesin-5 0.0119 0.1224 1
Schistosoma mansoni hypothetical protein 0.0025 0.0187 0.0206
Schistosoma mansoni importin beta-1 0.0035 0.0296 0.0331
Mycobacterium ulcerans beta-lactamase 0.0043 0.0391 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0195 0.2861
Echinococcus multilocularis cpg binding protein 0.0039 0.0341 0.0333
Schistosoma mansoni cpg binding protein 0.0039 0.0341 0.0384
Plasmodium vivax kinesin-5 0.0119 0.1224 1
Brugia malayi CXXC zinc finger family protein 0.0035 0.0294 0.2045
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0296 0.6537
Onchocerca volvulus 0.0043 0.0391 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0391 0.0441
Leishmania major GTP-binding protein, putative 0.0026 0.0195 0.2861
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.0666 0.4741
Giardia lamblia Kinesin-5 0.0119 0.1224 1
Schistosoma mansoni cpg binding protein 0.0035 0.0294 0.0329
Brugia malayi PHD-finger family protein 0.0032 0.0266 0.1799
Schistosoma mansoni zinc finger protein 0.0026 0.0195 0.0215
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0391 0.0441
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.014 0.0132
Loa Loa (eye worm) hypothetical protein 0.0043 0.0391 0.0907
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0.0148 0.014
Echinococcus granulosus zinc finger protein 0.0026 0.0195 0.0187

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0029 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.2617 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 9.4662 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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