Detailed information for compound 1349461

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 242.23 | Formula: C13H10N2O3
  • H donors: 2 H acceptors: 3 LogP: 2.87 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(cc1)N=Nc1ccccc1C(=O)O
  • InChi: 1S/C13H10N2O3/c16-10-7-5-9(6-8-10)14-15-12-4-2-1-3-11(12)13(17)18/h1-8,16H,(H,17,18)
  • InChiKey: DWQOTEPNRWVUDA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Caenorhabditis elegans Protein GLD-1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) tumor suppressor Get druggable targets OG5_170288 All targets in OG5_170288
Brugia malayi tumor suppressor. Get druggable targets OG5_170288 All targets in OG5_170288
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0001 0.0008
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0009 0.0001 0.0008
Schistosoma mansoni jumonji domain containing protein 0.0119 0.0058 0.0831
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0088 0.2366
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0006 0.1356
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.002 0.062
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0008 0.1624
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0043 0.0614
Schistosoma mansoni importin beta-1 0.0028 0.001 0.0147
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.009 0.0043 0.0614
Echinococcus granulosus JmjC domain containing protein 4 0.0032 0.0012 0.0175
Loa Loa (eye worm) RNA binding protein 0.0061 0.0028 0.084
Schistosoma mansoni coup transcription factor 0.002 0.0006 0.0088
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0001 0.0001
Schistosoma mansoni jumonji/arid domain-containing protein 0.0119 0.0058 0.0831
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0037 0.0529
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0784 0.041 0.585
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0008 0.0877
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0032 0.0012 0.0175
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0205
Toxoplasma gondii hypothetical protein 0.0027 0.001 0.0009
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.012 0.0059 1
Echinococcus granulosus lysine specific demethylase 5A 0.0119 0.0058 0.0831
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0299 0.0154 0.2192
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0004 0.0111
Echinococcus multilocularis expressed conserved protein 0.0089 0.0043 0.0611
Brugia malayi nuclear hormone receptor 0.0009 0.0001 0.0018
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0001 0.0017
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0009 0.1928
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.0046 0.0655
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0008 0.0007
Echinococcus granulosus nibrin 0.001 0.0001 0.0009
Schistosoma mansoni ferritin 0.0009 0 0.0003
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0028 0.0399
Brugia malayi jmjC domain containing protein 0.0119 0.0058 0.1783
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0001 0.0008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0004 0.0111
Trypanosoma brucei polo-like protein kinase 0.0098 0.0048 1
Echinococcus multilocularis phd:f box containing protein 0.0032 0.0012 0.0175
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0001 0.0031
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.001 0.2175
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0023 0.0325
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0023 0.0325
Brugia malayi Cathepsin L-like precursor 0.0016 0.0004 0.0127
Echinococcus multilocularis nuclear receptor nhr 48 0.0009 0.0001 0.0008
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0028 0.5938
Schistosoma mansoni hypothetical protein 0.0033 0.0013 0.0185
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0023
Loa Loa (eye worm) hypothetical protein 0.0033 0.0013 0.038
Brugia malayi Cathepsin L-like precursor 0.0016 0.0004 0.0127
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0001 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0004 0.0111
Schistosoma mansoni ferritin light chain 0.0009 0 0.0003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0125
Onchocerca volvulus 0.0713 0.0373 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0001 0.0018
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0037 0.0036
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0015 0.0401
Onchocerca volvulus 0.002 0.0006 0.015
Schistosoma mansoni ferritin 0.0009 0 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0001 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0005 0.0147
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0006 0.0189
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0004 0.0111
Echinococcus granulosus phd:f box containing protein 0.0032 0.0012 0.0175
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0119 0.0058 0.0831
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0006 0.0088
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.8917 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0019 0.0005 0.1151
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0004 0.0059
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0028 0.5938
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.011
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0009 0.028
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0006 0.0088
Brugia malayi hypothetical protein 0.001 0.0001 0.0019
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0006 0.0006
Plasmodium vivax vivapain-2 0.0016 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0171
Brugia malayi TAR-binding protein 0.0061 0.0028 0.0856
Leishmania major cathepsin L-like protease 0.0016 0.0004 0.0242
Brugia malayi Cathepsin L-like precursor 0.0016 0.0004 0.0127
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0019 0.0005 0.0477
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0004 0.0096
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0028 0.5938
Schistosoma mansoni alpha-glucosidase 0.0142 0.0071 0.1007
Brugia malayi Probable ClpP-like protease 0.0078 0.0037 0.1134
Echinococcus multilocularis muscleblind protein 0.0145 0.0072 0.1026
Brugia malayi DKFZp564C0469 protein 0.001 0.0001 0.0019
Schistosoma mansoni thyroid hormone receptor 0.002 0.0006 0.0088
Schistosoma mansoni apoferritin-2 0.0009 0 0.0003
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0005 0.0078
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0001 0.0001
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0137 0.3668
Brugia malayi nuclear hormone receptor 0.002 0.0006 0.0189
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0001 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0006 0.0189
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0003 0.0075
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0008 0.0236
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0043 0.0614
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0006 0.018
Echinococcus multilocularis muscleblind protein 1 0.0145 0.0072 0.1026
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0087 0.0041 0.059
Brugia malayi conserved hypotetical protein 0.0009 0.0001 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0005 0.0147
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.8917 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0015 0.0401
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0005 0.1151
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0004 0.001
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 1.8917 1 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0008 0.0203
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0006 0.0197
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0012 0.0002 0.0001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0004 0.001
Echinococcus granulosus serine protein kinase ATM 0.0026 0.0009 0.0131
Plasmodium vivax vivapain-2 0.0016 0.0004 0.0004
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0006 0.0088
Echinococcus granulosus importin subunit beta 1 0.0028 0.001 0.0147
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0048 0.1275
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0006 0.1241
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0019 0.0005 0.1151
Echinococcus granulosus muscleblind protein 0.0145 0.0072 0.1026
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0006 0.0171
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0028 0.0399
Echinococcus multilocularis snurportin 1 0.0298 0.0153 0.2182
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0001 0.0131
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0004 0.0111
Echinococcus multilocularis Ankyrin 0.0031 0.0012 0.0169
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.0046 0.0655
Brugia malayi tumor suppressor. 0.0388 0.0201 0.6147
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0005 0.015
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.006 0.1806
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0031 0.0012 0.0168
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0001 0.0031
Echinococcus granulosus death domain containing protein 0.0031 0.0012 0.0168
Schistosoma mansoni hypothetical protein 0.0298 0.0153 0.2182
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0059 0.0059
Brugia malayi nuclear hormone receptor family member nhr-6 0.0009 0.0001 0.0018
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0006 0.0088
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0125
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0028 0.5938
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0011 0.0001 0.0017
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0001 0.0017
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0004 0.011
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0009 0.0001 0.0008
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0001 0.0019
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0681 0.0356 0.5067
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0004 0.0059
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0005 0.048
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0004 0.011
Schistosoma mansoni hypothetical protein 0.0039 0.0016 0.0234
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0015 0.0401
Brugia malayi tailless protein 0.0009 0.0001 0.0018
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0003 0.0589
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0037 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0005 0.0147
Schistosoma mansoni patched 1 0.0041 0.0017 0.0245
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0008 0.0019
Schistosoma mansoni hypothetical protein 0.0039 0.0016 0.0234
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0171
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0028 0.5938
Loa Loa (eye worm) jmjC domain-containing protein 0.0119 0.0058 0.1768
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0005 0.0147
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0006 0.0088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0006 0.0171
Schistosoma mansoni zinc finger protein 0.0009 0.0001 0.0008
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.0083 0.118
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0137 0.3668
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0004 0.0111
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0032 0.0012 0.0012
Echinococcus granulosus cathepsin l1 0.0016 0.0004 0.0059
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0006 0.015
Brugia malayi hypothetical protein 0.0009 0.0001 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0005 0.0147
Echinococcus granulosus cathepsin l1 0.0011 0.0001 0.0019
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0001 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0001 0.0017
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0006 0.0088
Brugia malayi Importin beta-1 subunit 0.0028 0.001 0.0316
Loa Loa (eye worm) cysteine protease 0.0016 0.0004 0.011
Onchocerca volvulus 0.001 0.0001 0.0001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0006 0.0088
Trichomonas vaginalis set domain proteins, putative 0.0713 0.0373 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0015 0.3145
Brugia malayi RNA binding protein 0.0061 0.0028 0.0856
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0015 0.3145
Schistosoma mansoni ran 0.0021 0.0006 0.0092
Schistosoma mansoni phd/f-box containing protein 0.0032 0.0012 0.0175
Brugia malayi Protein kinase domain containing protein 0.0031 0.0012 0.0365
Giardia lamblia GTOR 0.0019 0.0005 0.1033
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0006 0.0088
Toxoplasma gondii aldehyde dehydrogenase 0.012 0.0059 0.0058
Brugia malayi nuclear receptor RXR 0.0011 0.0001 0.0036
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.8917 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0088 0.2366
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0006 0.0092
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.009 0.0043 0.0614
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0048 0.1275
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0004 0.0111
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0001 0.0008
Mycobacterium ulcerans hypothetical protein 0.0023 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0037
Onchocerca volvulus Netrin receptor homolog 0.0031 0.0012 0.0301
Trichomonas vaginalis ran, putative 0.0021 0.0006 0.0173
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0008 0.0007
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.0046 0.9669
Schistosoma mansoni hypothetical protein 0.0681 0.0356 0.5067
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.0005 0.0078
Schistosoma mansoni phosphatidylserine receptor 0.0032 0.0012 0.0175
Schistosoma mansoni ferritin light chain 0.0009 0 0.0003
Echinococcus multilocularis geminin 0.0681 0.0356 0.5067
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0004 0.0004
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0019 0.0005 0.0477
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0088 0.2366
Brugia malayi jmjC domain containing protein 0.0032 0.0012 0.0376
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0006 0.0171
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0171
Onchocerca volvulus 0.0016 0.0004 0.0096
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0008 0.0877
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0006 0.0006
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0001 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0171
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0009 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0345
Schistosoma mansoni hypothetical protein 0.0031 0.0012 0.0168
Brugia malayi Cathepsin L-like precursor 0.0016 0.0004 0.0127
Schistosoma mansoni nuclear receptor 0.0009 0.0001 0.0008
Schistosoma mansoni nuclear receptor 0.0009 0.0001 0.0008
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0004 0.0004
Onchocerca volvulus 0.0016 0.0004 0.0096
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0004 0.0111
Toxoplasma gondii cathepsin CPL 0.0016 0.0004 0.0004
Echinococcus granulosus replication factor c subunit 1 0.001 0.0001 0.0009
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0017 0.0245
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0004 0.001
Echinococcus multilocularis netrin receptor unc 5 0.0031 0.0012 0.0168
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0015 0.044
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0004 0.0127
Onchocerca volvulus 0.0016 0.0004 0.0096
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0001 0.004
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0006 0.0189
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0006 0.0088
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0003 0.0589
Loa Loa (eye worm) ctsf protein 0.0016 0.0004 0.011
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0003 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0006 0.0189
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.0068 0.0963
Onchocerca volvulus 0.0095 0.0046 0.1222
Giardia lamblia Kinase, PLK 0.0098 0.0048 1
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0048 0.1275
Echinococcus granulosus histone lysine methyltransferase setb 0.009 0.0043 0.0614
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0005 0.0147
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0015 0.0401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0001 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0005 0.0147
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0219
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0004 0.0096
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0088 0.2366
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0267 0.0137 0.4182
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0006 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0005 0.0147
Echinococcus granulosus nuclear factor of activated T cells 5 0.0299 0.0154 0.2192
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0004 0.0874
Loa Loa (eye worm) hypothetical protein 0.0095 0.0046 0.139
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0031 0.0012 0.0169
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0032 0.0012 0.259
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0009 0.0246
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0171
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0009 0.0001 0.0008
Trypanosoma brucei glucosidase, putative 0.0037 0.0015 0.3145
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0006 0.0171
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0037 0.0037
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0023 0.0058
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0006 0.0088
Schistosoma mansoni DNA ligase IV 0.001 0.0001 0.0009
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0005 0.0078
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0059 0.0839
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0004 0.0111
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 1.8917 1 1
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0006 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0001 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0004 0.0111
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0088 0.2366
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0006 0.0006
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0009 0.0001 0.0008
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0004 0.0096
Echinococcus multilocularis jumonji domain containing 1A 0.0032 0.0012 0.0175
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0015 0.0213
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.7391 0.3905 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0005 0.0011
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0026 0.0009 0.0131
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0001 0.0017
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0018
Echinococcus granulosus snurportin 1 0.0298 0.0153 0.2182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0004 0.0111
Schistosoma mansoni alpha glucosidase 0.0037 0.0015 0.0213
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0001 0.0009
Loa Loa (eye worm) hypothetical protein 0.0083 0.0039 0.119
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0005 0.0147
Schistosoma mansoni hypothetical protein 0.0047 0.002 0.0289
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0019 0.0005 0.1151
Brugia malayi Temporarily assigned gene name protein 44 0.0033 0.0013 0.0397
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0031 0.0012 0.0343
Echinococcus multilocularis expressed protein 0.0009 0 0.0003
Schistosoma mansoni aldehyde dehydrogenase 0.012 0.0059 0.0839
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0093 0.25
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0032 0.0012 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0015 0.3145
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0001 0.0017
Schistosoma mansoni alpha-glucosidase 0.0142 0.0071 0.1007
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.001 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0028 0.5938
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0005 0.1155
Schistosoma mansoni ran 0.0021 0.0006 0.0092
Plasmodium falciparum JmjC domain-containing protein, putative 0.0032 0.0012 0.0012
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0028 0.5938
Echinococcus multilocularis cysteine protease 0.0016 0.0004 0.0059
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0028 0.0399
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.0046 0.1406
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0012 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0005 0.0147
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0023 0.0058
Echinococcus multilocularis importin subunit beta 1 0.0028 0.001 0.0147
Schistosoma mansoni hypothetical protein 0.0033 0.0013 0.0185
Loa Loa (eye worm) hypothetical protein 0.0229 0.0117 0.3554
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0015 0.0401
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0004 0.0059
Entamoeba histolytica hypothetical protein 0.001 0.0001 0.0131
Plasmodium vivax SET domain protein, putative 0.009 0.0043 0.0043
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0008 0.0203
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0037 0.0036
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0006 0.015
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0098 0.0048 0.1439
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.0117 0.1661
Echinococcus multilocularis microtubule associated protein 2 0.1335 0.0702 1
Echinococcus granulosus geminin 0.0681 0.0356 0.5067
Schistosoma mansoni jumonji/arid domain-containing protein 0.0119 0.0058 0.0831
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0048 0.1275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0005 0.0147
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0028 0.0399
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0004 0.0111
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.012 0.0059 0.0839
Echinococcus granulosus hypothetical protein 0.0033 0.0013 0.0185
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0031 0.0012 0.0168
Plasmodium falciparum importin beta, putative 0.0028 0.001 0.001
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0019 0.0005 0.1151
Plasmodium vivax importin-beta 2, putative 0.0028 0.001 0.001
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0119 0.0058 0.0831
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0006 0.0189
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0006 0.0088
Brugia malayi ecdysone receptor 0.0009 0.0001 0.0018
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.0083 0.252
Trypanosoma cruzi target of rapamycin kinase 3 0.0019 0.0005 0.1151
Entamoeba histolytica hypothetical protein 0.0023 0.0008 0.1588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0004 0.0111
Loa Loa (eye worm) hypothetical protein 0.0032 0.0012 0.0359
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0137 0.3668
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.0083 0.118
Loa Loa (eye worm) hypothetical protein 0.009 0.0043 0.1303
Schistosoma mansoni thyroid hormone receptor 0.002 0.0006 0.0088
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0018
Echinococcus multilocularis JmjC domain containing protein 4 0.0032 0.0012 0.0175
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0019 0.0005 0.1151
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0001 0.0017
Brugia malayi topoisomerase 0.001 0.0001 0.0019
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.012 0.0059 0.0839
Onchocerca volvulus 0.009 0.0043 0.1143
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0015 0.0401
Brugia malayi hypothetical protein 0.0229 0.0117 0.3565
Leishmania major cathepsin L-like protease 0.0016 0.0004 0.0242
Entamoeba histolytica serine/threonine protein kinase, putative 0.0098 0.0048 1
Echinococcus granulosus expressed conserved protein 0.0089 0.0043 0.0611
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0006 0.0189
Brugia malayi jmjC domain containing protein 0.0032 0.0012 0.0376
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0005 0.0147
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0006 0.0088
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0008 0.0007
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0032 0.0012 0.259
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.0005 0.0078
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0006 0.0088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0004 0.0111
Loa Loa (eye worm) hypothetical protein 0.005 0.0022 0.0658
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0005 0.0147
Loa Loa (eye worm) hypothetical protein 0.0032 0.0012 0.0359
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0008 0.0007
Echinococcus multilocularis protein patched 0.0041 0.0017 0.0245
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0028 0.5938
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0006 0.0088
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0125
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.001 0.2175
Entamoeba histolytica cysteine protease, putative 0.0016 0.0004 0.0874
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0006 0.0189
Plasmodium vivax JmjC domain containing protein 0.0032 0.0012 0.0012
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0006 0.0088
Schistosoma mansoni hypothetical protein 0.0039 0.0016 0.0234
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0008 0.0019
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0011 0.0001 0.0244
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0004 0.001
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.001 0.001
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0001 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0028 0.5938
Leishmania major cathepsin L-like protease 0.0062 0.0028 0.4534
Echinococcus granulosus ferritin 0.0009 0 0.0003
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0009 0.0001 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0005 0.0147
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0137 0.3668
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0006 0.0189
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0006 0.0088
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.009 0.0043 0.0042
Echinococcus multilocularis lysine specific demethylase 6a 0.0032 0.0012 0.0175
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0008 0.0877
Echinococcus multilocularis cysteine protease 0.0016 0.0004 0.0059
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0028 0.0856
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0004 0.0111
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0008 0.0007
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0004 0.0059
Echinococcus multilocularis protein dispatched 1 0.0047 0.002 0.0289
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0001 0.0008
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0008 0.0007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0006 0.0088
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0043 0.0614
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0001 0.0017
Schistosoma mansoni topbp1 0.001 0.0001 0.0009
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0006 0.0189
Schistosoma mansoni survival motor neuron protein 0.0047 0.002 0.0289
Brugia malayi serine/threonine-protein kinase plk-2 0.0098 0.0048 0.1454
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0137 0.3668
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0028 0.5938
Brugia malayi Uncoordinated protein 44 0.0031 0.0012 0.036
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0019 0.0005 0.1151
Brugia malayi Cathepsin L-like precursor 0.0016 0.0004 0.0127
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0003 0.0589
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0028 0.5938
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0023
Brugia malayi hypothetical protein 0.001 0.0001 0.0019
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0006 0.1356
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0011 0.0001 0.0244
Brugia malayi hypothetical protein 0.0009 0.0001 0.0018
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0171
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0006 0.0171
Echinococcus multilocularis serine protein kinase ATM 0.0026 0.0009 0.0131
Schistosoma mansoni fkbp-rapamycin associated protein 0.0011 0.0001 0.0017
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0006 0.0088
Onchocerca volvulus Serine\/threonine kinase homolog 0.0098 0.0048 0.1261
Brugia malayi nuclear receptor NHR-88 0.002 0.0006 0.0189
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0001 0.0031
Brugia malayi nuclear receptor RXR 0.0009 0.0001 0.0018
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0004 0.0874
Echinococcus granulosus nuclear receptor nhr 48 0.0009 0.0001 0.0008
Leishmania major cathepsin L-like protease 0.0062 0.0028 0.4534
Echinococcus granulosus netrin receptor unc 5 0.0031 0.0012 0.0168
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0001 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0005 0.0147
Schistosoma mansoni microtubule-associated protein tau 0.1335 0.0702 1
Brugia malayi nuclear receptor NHR-67 0.0009 0.0001 0.0018
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0003 0.0075
Leishmania major importin beta-1 subunit, putative 0.0023 0.0008 0.0847
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0037 0.0037
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0007 0.1528
Schistosoma mansoni nuclear hormone receptor 0.002 0.0006 0.0088
Brugia malayi steroid hormone receptor 0.002 0.0006 0.0189
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0004 0.0111
Echinococcus granulosus FTZ F1 alpha 0.002 0.0006 0.0088
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0004 0.0059
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0015 0.2166
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0001 0.0017
Entamoeba histolytica Ran family GTPase 0.0021 0.0006 0.1356
Loa Loa (eye worm) hypothetical protein 0.0028 0.001 0.0299
Leishmania major cathepsin L-like protease 0.0016 0.0004 0.0242
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0026 0.0009 0.1928
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0006 0.0171
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0018
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0032 0.0012 0.0175
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0219
Schistosoma mansoni apoferritin-2 0.0009 0 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0028 0.5938
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0028 0.084
Echinococcus multilocularis ferritin 0.0009 0 0.0003
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0003 0.0075
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.001 0.001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0004 0.0111
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0008 0.0203
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.0117 0.1661
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0003 0.0075
Brugia malayi Pre-SET motif family protein 0.0627 0.0327 1
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0001 0.0131
Brugia malayi jmjC domain containing protein 0.0032 0.0012 0.0376
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0037 0.0036
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0003 0.0075
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0005 0.0167
Schistosoma mansoni hypothetical protein 0.0039 0.0016 0.0234
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0047 0.0666
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0002 0.0048
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0017 0.0509
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0004 0.0004
Leishmania major cathepsin L-like protease 0.0016 0.0004 0.0242
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0298 0.0153 0.4673
Schistosoma mansoni protein phosphatase 2C 0.0032 0.0012 0.0175
Loa Loa (eye worm) jmjC domain-containing protein 0.0032 0.0012 0.0359
Brugia malayi nuclear receptor NHR-88 0.0009 0.0001 0.0018
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0019 0.0005 0.1151
Onchocerca volvulus 0.0016 0.0004 0.0096
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0037 0.0036
Toxoplasma gondii target of rapamycin (TOR), putative 0.0019 0.0005 0.0005
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.006 0.1806
Brugia malayi jmjC domain containing protein 0.0119 0.0058 0.1783
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0001 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0001 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0028 0.5938
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0019 0.0005 0.0477
Echinococcus granulosus lysine specific demethylase 6a 0.0032 0.0012 0.0175
Trichomonas vaginalis ferritin, putative 0.0009 0 0.0006
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0032 0.0012 0.0175
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0001 0.0278
Brugia malayi jmjC domain containing protein 0.0032 0.0012 0.0376
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0015 0.0401
Brugia malayi MH2 domain containing protein 0.0121 0.006 0.182
Brugia malayi Cathepsin L-like precursor 0.0011 0.0001 0.004
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0006 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0005 0.0147
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0037 0.0529
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0003 0.006
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.0083 0.118
Schistosoma mansoni jumonji domain containing protein 0.0032 0.0012 0.0175
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0028 0.5938
Leishmania major cathepsin L-like protease 0.0016 0.0004 0.0242
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0037 0.0037
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0088 0.2366
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0019 0.0005 0.1151
Entamoeba histolytica hypothetical protein 0.0026 0.0009 0.1928
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0006 0.0189
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0001 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0005 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0004 0.0111
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0008 0.0007
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0008 0.0007
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 1.8917 1 1
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0001 0.0019
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0006 0.0088
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0004 0.0059
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0098 0.0048 0.7977
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0015 0.0213
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0004 0.0111
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0004 0.0111
Brugia malayi orphan nuclear receptor NR2E1 0.0009 0.0001 0.0018
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0001 0.0017
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0011 0.0001 0.0017
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0343
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0028 0.0399
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0005 0.0005
Brugia malayi Death domain containing protein 0.0031 0.0012 0.036
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.012 0.0059 0.015
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0017 0.0245
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0021 0.0571
Echinococcus multilocularis nibrin 0.001 0.0001 0.0009
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0001 0.000000014223
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0018
Loa Loa (eye worm) hypothetical protein 0.001 0.0001 0.0001
Brugia malayi RNA, U transporter 1 0.0079 0.0038 0.1148
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0004 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0006 0.0189
Loa Loa (eye worm) hypothetical protein 0.0145 0.0072 0.2189
Leishmania major cathepsin L-like protease 0.0062 0.0028 0.4534
Brugia malayi nuclear hormone receptor family member odr-7 0.0009 0.0001 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0005 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0004 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0001 0.0017
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0001 0.0017
Onchocerca volvulus 0.0011 0.0001 0.002
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0001 0.0018
Brugia malayi Pre-SET motif family protein 0.009 0.0043 0.1319
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0021 0.4469
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0001 0.0017
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.0083 0.2533
Brugia malayi Muscleblind-like protein 0.0145 0.0072 0.2203
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0006 0.0171
Brugia malayi hypothetical protein 0.0011 0.0001 0.0036
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0037 0.0037
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0019 0.0005 0.1151
Toxoplasma gondii FATC domain-containing protein 0.0026 0.0009 0.0009
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.0048 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0001 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0088 0.2366
Trichomonas vaginalis glucosylceramidase, putative 0.0267 0.0137 0.3668
Schistosoma mansoni ankyrin 23/unc44 0.0031 0.0012 0.0168
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0032 0.0012 0.259
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.001 0.001
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0015 0.0401
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0267 0.0137 0.4172
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.8917 1 1
Brugia malayi CHE-14 protein 0.0041 0.0017 0.0526
Schistosoma mansoni nuclear receptor nhr-48 0.0009 0.0001 0.0008
Schistosoma mansoni netrin receptor unc5 0.0031 0.0012 0.0168
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.0001 0.0036
Loa Loa (eye worm) hypothetical protein 0.0145 0.0072 0.2189
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0004 0.0111
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0098 0.0048 0.0677
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0006 0.0088
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0004 0.0111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0005 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0004 0.0111
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0005 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0005 0.0147
Onchocerca volvulus 0.0023 0.0008 0.0192
Leishmania major GTP-binding protein, putative 0.0021 0.0006 0.065
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0015 0.0457
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0048 0.1275
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0006 0.0088
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0012 0.0002 0.0378
Brugia malayi ecdysteroid receptor 0.002 0.0006 0.0189
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0005 0.1151
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0001 0.0131
Loa Loa (eye worm) hypothetical protein 0.0041 0.0017 0.0509
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0048 0.1275
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0219
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0006 0.0088
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0005 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0005 0.0147
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0005 0.0147
Echinococcus granulosus thyroid hormone receptor alpha 0.0009 0.0001 0.0008
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0037 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0005 0.0147
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0003 0.0589
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0005 0.0005
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.0068 0.0963
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0008 0.1588
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0006 0.0189
Echinococcus granulosus microtubule associated protein 2 0.1335 0.0702 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0005 0.0004
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0083 0.0039 0.8292
Loa Loa (eye worm) hypothetical protein 0.0032 0.0012 0.0359
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0098 0.0048 0.0677
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0017 0.0245
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0003 0.0075
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0037 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0005 0.0147
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0001 0.0036
Schistosoma mansoni ferritin 0.0009 0 0.0003
Leishmania major hypothetical protein, conserved 0.0032 0.0012 0.1696
Brugia malayi hypothetical protein 0.0033 0.0013 0.0397
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.009 0.0043 0.0614
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0021 0.0571
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0006 0.0189
Onchocerca volvulus 0.0016 0.0004 0.0096
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0083 0.0039 0.8292
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0015 0.3145
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0028 0.5938
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0004 0.0874
Onchocerca volvulus Glucosylceramidase homolog 0.0175 0.0088 0.2354
Onchocerca volvulus 0.0016 0.0004 0.0096
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0068
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0015 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0006 0.0189
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0001 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0001 0.0035
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0001 0.0131
Loa Loa (eye worm) jmjC domain-containing protein 0.0032 0.0012 0.0359
Leishmania major phosphatidylinositol 3-kinase, putative 0.0019 0.0005 0.0477
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0008 0.0236
Brugia malayi Cathepsin L-like precursor 0.0016 0.0004 0.0127
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0023
Echinococcus multilocularis lysine specific demethylase 5A 0.0119 0.0058 0.0831
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0093 0.25
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0125
Loa Loa (eye worm) hypothetical protein 0.0078 0.0037 0.1119
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.001 0.001
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0008 0.0007
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0005 0.015
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0004 0.0242
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0003 0.0086
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.0048 1
Echinococcus granulosus Ankyrin 0.0031 0.0012 0.0169
Onchocerca volvulus 0.0047 0.002 0.0529
Entamoeba histolytica protein kinase rad3, putative 0.0011 0.0001 0.0244
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0008 0.1624
Brugia malayi Cathepsin L-like precursor 0.0011 0.0001 0.004
Loa Loa (eye worm) jmjC domain-containing protein 0.0032 0.0012 0.0359
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0037 0.0037
Mycobacterium ulcerans aldehyde dehydrogenase 0.012 0.0059 0.0059
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0019 0.0005 0.0477
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0006 0.0088
Schistosoma mansoni kinase 0.005 0.0022 0.0313
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0028 0.0399
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0005 0.0147
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0006 0.1356
Loa Loa (eye worm) tumor suppressor 0.0388 0.0201 0.614
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0048 0.0677
Schistosoma mansoni ferritin 0.0009 0 0.0003
Echinococcus granulosus protein quaking 0.0033 0.0013 0.0185
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0008 0.0236
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0001 0.0017
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0015 0.0401
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0002 0.0048
Echinococcus granulosus jumonji domain containing 1A 0.0032 0.0012 0.0175
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0028 0.084
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0004 0.0111
Loa Loa (eye worm) fibroinase 0.0016 0.0004 0.011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0005 0.0147
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0005 0.0167
Echinococcus multilocularis protein quaking 0.0033 0.0013 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0005 0.0147
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0003 0.0075
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0006 0.0189
Echinococcus granulosus expressed protein 0.0009 0 0.0003
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0008 0.1624
Schistosoma mansoni topbp1 0.001 0.0001 0.0009
Onchocerca volvulus 0.0016 0.0004 0.0096
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0023 0.0023
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.0025 0.5342
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0006 0.0189
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0006 0.0171
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0006 0.015
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0125
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0627 0.0327 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0005 0.0147
Brugia malayi hypothetical protein 0.0011 0.0001 0.0036
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0004 0.0059
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0005 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0005 0.0147
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0017 0.0462
Echinococcus granulosus tar DNA binding protein 0.0061 0.0028 0.0399
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0048 0.1275
Brugia malayi cathepsin L-like precursor 0.0011 0.0001 0.004
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0006 0.0088
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0001 0.0131
Loa Loa (eye worm) hypothetical protein 0.002 0.0006 0.0171

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 22.311 uM PUBCHEM_BIOASSAY: Fluorescence polarization-based cell-based high throughput dose response assay to identify activators of insulin-degrading enzyme (IDE). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493087, AID493124, AID588681] ChEMBL. No reference
EC50 (binding) = 26.856 uM PUBCHEM_BIOASSAY: Counterscreen for IDE activators: Fluorescence polarization-based biochemical high throughput dose response assay for activators of recombinant IDE. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493087, AID493124, AID588439, AID588440, AID588442] ChEMBL. No reference
EC50 (functional) = 50.253 uM PUBCHEM_BIOASSAY: Counterscreen for IDE activators: Fluorescence polarization-based biochemical high throughput dose response assay to identify fluorescent artifacts and/or optically active compounds. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493087, AID493124, AID588681] ChEMBL. No reference
IC50 (binding) = 8.401 uM PUBCHEM_BIOASSAY: Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of GLD-1 protein - TGE RNA interaction. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2280, AID2290, AID2459] ChEMBL. No reference
IC50 (binding) = 22.02 um PUBCHEM_BIOASSAY: Counterscreen for inhibitors of gld-1: Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of the HIV Rev protein-RRE RNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2290 (Summary (gld-1 inhibitors)), 2280 (Primary screen (gld-1 inhibitors in singlicate))] ChEMBL. No reference
IC50 (functional) > 89.184 uM PUBCHEM_BIOASSAY: Counterscreen for activators of insulin-degrading enzyme (IDE): fluorescence-based cell-based high throughput dose response LDH release assay to identify compounds that are cytotoxic to HEK cells or compromise cell membrane permeability. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493087, AID493124, AID588681] ChEMBL. No reference
Potency (functional) 1.1582 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 29.9349 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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