Detailed information for compound 1354984

Basic information

Technical information
  • TDR Targets ID: 1354984
  • Name: 2-(2,4-dimethylphenoxy)-N-[4-([1,3]oxazolo[4, 5-b]pyridin-2-yl)phenyl]acetamide
  • MW: 373.405 | Formula: C22H19N3O3
  • H donors: 1 H acceptors: 3 LogP: 4.29 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)c1nc2c(o1)cccn2)COc1ccc(cc1C)C
  • InChi: 1S/C22H19N3O3/c1-14-5-10-18(15(2)12-14)27-13-20(26)24-17-8-6-16(7-9-17)22-25-21-19(28-22)4-3-11-23-21/h3-12H,13H2,1-2H3,(H,24,26)
  • InChiKey: IAPZEVVXHHFINT-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-(2,4-dimethylphenoxy)-N-(4-oxazolo[4,5-b]pyridin-2-ylphenyl)acetamide
  • 2-(2,4-dimethylphenoxy)-N-[4-(2-oxazolo[4,5-b]pyridinyl)phenyl]acetamide
  • 2-(2,4-dimethylphenoxy)-N-[4-([1,3]oxazolo[4,5-b]pyridin-2-yl)phenyl]ethanamide
  • BIM-0046410.P001
  • Oprea1_706791
  • 2-(2,4-dimethylphenoxy)-N-(4-[1,3]oxazolo[4,5-b]pyridin-2-ylphenyl)acetamide
  • MLS000061502
  • SMR000070681
  • CBMicro_046415
  • ZINC01218580

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens adrenoceptor beta 2, surface Starlite/ChEMBL No references
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) HTH-type transcriptional regulator EthR Starlite/ChEMBL References
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references
Homo sapiens protein tyrosine kinase 2 beta Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum expressed protein Get druggable targets OG5_130513 All targets in OG5_130513
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum expressed protein Get druggable targets OG5_130513 All targets in OG5_130513
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_130513 All targets in OG5_130513
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium ulcerans TetR family transcriptional regulator Get druggable targets OG5_191427 All targets in OG5_191427
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans AcrR family transcriptional regulator Get druggable targets OG5_191427 All targets in OG5_191427
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis protein tyrosine kinase Get druggable targets OG5_130513 All targets in OG5_130513
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR Get druggable targets OG5_191427 All targets in OG5_191427
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR Get druggable targets OG5_191427 All targets in OG5_191427
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) TK/FAK protein kinase Get druggable targets OG5_130513 All targets in OG5_130513
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans transcriptional regulator Get druggable targets OG5_191427 All targets in OG5_191427
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus protein tyrosine kinase Get druggable targets OG5_130513 All targets in OG5_130513
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Schistosoma japonicum Protein tyrosine kinase 2 beta, putative Get druggable targets OG5_130513 All targets in OG5_130513
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_130513 All targets in OG5_130513
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Mycobacterium tuberculosis Probable transcriptional regulator HTH-type transcriptional regulator EthR   217 aa 184 aa 27.2 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.1018 0.0952
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0042 0.0309 0.1913
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0127 0.1337 0.1275
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0339 0.6924
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0027 0.0129 0.005
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0042 0.0309 0.2047
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.1018 0.0952
Loa Loa (eye worm) TK/FAK protein kinase 0.0309 0.3555 1
Entamoeba histolytica P-glyco protein 6, putative 0.0042 0.0309 0.8843
Entamoeba histolytica hypothetical protein 0.0043 0.0324 0.9433
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0127 0.1337 0.1275
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0267 0.0201
Trichomonas vaginalis ABC transporter, putative 0.0042 0.0309 0.2047
Plasmodium falciparum multidrug resistance protein 1 0.0042 0.0309 1
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0139 0.014
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0028 0.0139 0.5
Echinococcus multilocularis geminin 0.0205 0.2287 0.2238
Entamoeba histolytica hypothetical protein 0.0043 0.0324 0.9433
Echinococcus multilocularis voltage gated potassium channel 0.0039 0.0267 0.0191
Brugia malayi hypothetical protein 0.0043 0.0324 0.0705
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0053 0.0441 0.6472
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0339 0.0261
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0027 0.0129 0.005
Echinococcus granulosus geminin 0.0205 0.2287 0.2238
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0454 0.1077
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0042 0.0309 1
Echinococcus granulosus multidrug resistance protein 1 0.0029 0.0154 0.0076
Trichomonas vaginalis taga, putative 0.0042 0.0309 0.2047
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0027 0.0129 0.0143
Loa Loa (eye worm) hypothetical protein 0.0042 0.0309 0.0661
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0042 0.0304 0.0227
Schistosoma mansoni multidrug resistance protein 0.0042 0.0309 0.0244
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0454 1
Schistosoma mansoni voltage-gated potassium channel 0.0138 0.1475 0.1425
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0042 0.0309 0.1913
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0324 0.0249
Schistosoma mansoni hypothetical protein 0.0043 0.0324 0.0259
Loa Loa (eye worm) hypothetical protein 0.0101 0.1027 0.2727
Echinococcus multilocularis hyperpolarization activated cyclic 0.0027 0.0129 0.005
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0027 0.0129 0.0061
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.994 1
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.0833 0.994 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0027 0.0129 0.0143
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.0639 1
Loa Loa (eye worm) multidrug resistance protein 3 0.0042 0.0309 0.0661
Schistosoma mansoni multidrug resistance protein 0.0042 0.0309 0.0244
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0042 0.0309 0.2047
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0282 0.0144
Loa Loa (eye worm) hypothetical protein 0.0039 0.0267 0.0541
Echinococcus multilocularis protein tyrosine kinase 0.0305 0.3511 0.348
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0339 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0042 0.0309 0.2047
Mycobacterium ulcerans transcriptional regulator 0.0838 1 1
Entamoeba histolytica P-glycoprotein-2 0.0042 0.0309 0.8843
Echinococcus multilocularis hyperpolarization activated cyclic 0.0027 0.0129 0.005
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.0639 0.161
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0042 0.0309 0.0311
Echinococcus granulosus hyperpolarization activated cyclic 0.0027 0.0129 0.005
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0339 0.4633
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0042 0.0309 0.0233
Onchocerca volvulus 0.01 0.1018 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0042 0.0309 0.0233
Entamoeba histolytica hypothetical protein 0.0043 0.0324 0.9433
Schistosoma mansoni hypothetical protein 0.0205 0.2287 0.2247
Trichomonas vaginalis ABC transporter, putative 0.0042 0.0309 0.2047
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0079 0.0011
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.1018 0.0962
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0027 0.0129 0.005
Schistosoma mansoni smdr2 0.0042 0.0309 0.0244
Loa Loa (eye worm) hypothetical protein 0.0027 0.0129 0.0143
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0282 0.0283
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0042 0.0309 0.0233
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0339 0.2315
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0027 0.0129 0.0442
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0042 0.0309 0.4107
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0258 0.4775
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0042 0.0309 0.2047
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0339 0.2309
Onchocerca volvulus 0.0058 0.0505 0.2759
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0339 0.6941
Brugia malayi Protein kinase domain containing protein 0.0309 0.3555 1
Brugia malayi follicle stimulating hormone receptor 0.0283 0.3235 0.9081
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0582 0.1447
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0339 0.0264
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0042 0.0309 0.2047
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0116 0.1202 1
Brugia malayi multidrug resistance protein 3 0.0042 0.0309 0.0661
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0042 0.0309 0.2047
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0339 0.0274
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.0639 0.0578
Echinococcus multilocularis multidrug resistance protein 1 0.0029 0.0154 0.0076
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0027 0.0129 0.0442
Echinococcus granulosus voltage gated potassium channel 0.0039 0.0267 0.0191
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0042 0.0309 0.0661
Schistosoma mansoni hypothetical protein 0.0205 0.2287 0.2247
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0042 0.0309 0.0233
Schistosoma mansoni DNA polymerase eta 0.0054 0.0454 0.039
Trichomonas vaginalis abcb9, putative 0.0042 0.0309 0.2047
Trichomonas vaginalis abcb9, putative 0.0042 0.0309 0.2047
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0339 0.0264
Echinococcus granulosus sodium channel protein 0.0053 0.0441 0.0367
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0027 0.0129 0.005
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0339 0.2315
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0127 0.1337 0.3618
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0339 0.0264
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0042 0.0309 0.0233
Loa Loa (eye worm) hypothetical protein 0.01 0.1018 0.27
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0127 0.1337 0.3618
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0339 0.2309
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0079 0.008
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.3272 0.3238
Echinococcus granulosus multidrug resistance protein 1 0.0042 0.0309 0.0233
Leishmania major p-glycoprotein 0.0042 0.0309 0.4107
Trichomonas vaginalis ABC transporter, putative 0.0042 0.0309 0.2047
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0139 0.0061
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0042 0.0309 0.0233
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0339 0.0264
Entamoeba histolytica P-glycoprotein 5, putative 0.0042 0.0309 0.8843
Echinococcus multilocularis dna polymerase eta 0.0054 0.0454 0.038
Loa Loa (eye worm) hypothetical protein 0.0045 0.0339 0.0748
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0042 0.0309 0.2047
Entamoeba histolytica P-glycoprotein-5 0.0042 0.0309 0.8843
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0267 0.0201
Echinococcus granulosus multidrug resistance protein 1 0.0029 0.0154 0.0076
Echinococcus granulosus multidrug resistance protein 1 0.0042 0.0309 0.0233
Entamoeba histolytica hypothetical protein 0.0043 0.0324 0.9433
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0042 0.0309 0.2047
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0042 0.0309 0.0233
Schistosoma mansoni inositol monophosphatase 0.0045 0.0339 0.0274
Echinococcus multilocularis ATP binding cassette sub family B 0.0042 0.0304 0.0227
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0042 0.0309 0.2047
Brugia malayi ABC transporter family protein 0.0042 0.0309 0.0661
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.3272 0.3238
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0639 0.0564
Brugia malayi Inositol-1 0.0045 0.0339 0.0746
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0027 0.0129 0.005
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0079 0.008
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0283 0.3235 0.9081
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0042 0.0309 0.2047
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0324 0.0249
Entamoeba histolytica P-glycoprotein-1 0.0042 0.0309 0.8843
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0042 0.0309 0.2047
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0042 0.0309 0.2047
Schistosoma mansoni survival motor neuron protein 0.0058 0.0505 0.0442
Loa Loa (eye worm) hypothetical protein 0.0054 0.0454 0.1077
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0039 0.0267 0.0541
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0505 0.1224
Echinococcus multilocularis multidrug resistance protein 1 0.0042 0.0309 0.0233
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0027 0.0129 0.0061
Brugia malayi hypothetical protein 0.0286 0.3272 0.9186
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0042 0.0309 0.2047
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0339 0.6941
Loa Loa (eye worm) hypothetical protein 0.0042 0.0309 0.0661
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0027 0.0129 0.0061
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0042 0.0309 0.2047
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0042 0.0309 0.0233
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0079 0.0011
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0339 0.0264
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0639 0.0564
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0339 0.6924
Echinococcus granulosus microtubule associated protein 2 0.0833 0.994 1
Leishmania major DNA polymerase eta, putative 0.0038 0.0258 0.3195
Echinococcus granulosus hyperpolarization activated cyclic 0.0027 0.0129 0.005
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0339 0.0748
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0042 0.0309 0.2047
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0042 0.0309 0.2047
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0027 0.0129 0.0061
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0039 0.0267 0.0191
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0029 0.0154 0.0666
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0339 1
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0339 0.0263
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.1018 0.27
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0339 0.0264
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0042 0.0309 0.2047
Schistosoma mansoni voltage-gated potassium channel 0.0138 0.1475 0.1425
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0339 1
Mycobacterium ulcerans TetR family transcriptional regulator 0.0838 1 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0639 0.0568
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0042 0.0309 0.2047
Loa Loa (eye worm) hypothetical protein 0.0101 0.1027 0.2727
Echinococcus granulosus protein tyrosine kinase 0.0305 0.3511 0.348
Schistosoma mansoni hypothetical protein 0.0058 0.0505 0.0442
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0339 0.9975
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0339 0.0263
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0339 0.2309
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0116 0.1202 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0042 0.0309 0.2047
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0042 0.0309 0.2047
Echinococcus multilocularis multidrug resistance protein 1 0.0042 0.0309 0.0233
Echinococcus multilocularis sodium channel protein 0.0053 0.0441 0.0367
Echinococcus granulosus multidrug resistance protein 1 0.0042 0.0309 0.0233
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0042 0.0309 0.2047
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0258 0.1338
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0339 0.0274
Loa Loa (eye worm) inositol-1 0.0045 0.0339 0.0746
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0139 0.1073
Leishmania major DNA polymerase eta, putative 0.0054 0.0454 0.6692
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0339 0.2244
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0053 0.0441 0.0367
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0027 0.0129 0.005
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0639 0.0568
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.0454 1
Schistosoma mansoni multidrug resistance protein 0.0042 0.0309 0.0244
Schistosoma mansoni tyrosine kinase 0.0305 0.3511 0.3487
Toxoplasma gondii hypothetical protein 0.0101 0.1027 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0324 0.0259
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0339 0.6941
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0339 0.4645
Plasmodium vivax multidrug resistance protein 1, putative 0.0042 0.0309 1
Trichomonas vaginalis ABC transporter, putative 0.0042 0.0309 0.2047
Entamoeba histolytica P-glycoprotein-2, putative 0.0042 0.0309 0.8843
Entamoeba histolytica hypothetical protein 0.0028 0.0139 0.231
Mycobacterium ulcerans AcrR family transcriptional regulator 0.0838 1 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.1027 0.2727
Loa Loa (eye worm) hypothetical protein 0.0286 0.3272 0.9186
Loa Loa (eye worm) hypothetical protein 0.0042 0.0304 0.0645
Echinococcus granulosus dna polymerase eta 0.0054 0.0454 0.038
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0101 0.1027 0.2727
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.0639 0.0643
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0139 0.0061
Brugia malayi Cyclic-nucleotide gated cation channel 0.0027 0.0129 0.0143
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0042 0.0309 0.2047
Trichomonas vaginalis abcb9, putative 0.0042 0.0309 0.2047
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0139 0.1604
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0027 0.0129 0.0061
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.994 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0339 0.2315
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0339 0.6924
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0129 0.0061
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0039 0.0267 0.0191
Entamoeba histolytica P-glycoprotein-2 0.0042 0.0309 0.8843
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0042 0.0309 0.0233
Schistosoma mansoni inositol monophosphatase 0.0045 0.0339 0.0274
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0027 0.0129 0.005
Loa Loa (eye worm) hypothetical protein 0.011 0.1138 0.3046

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.0927 uM PUBCHEM_BIOASSAY: Dose response for HTS for Beta-2AR agonists via FAP method from CP1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485366, AID492947, AID504448] ChEMBL. No reference
EC50 (functional) = 0.316 uM PUBCHEM_BIOASSAY: Dose response for HTS for Beta-2AR agonists via FAP method from CP1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485366, AID492947, AID504448] ChEMBL. No reference
EC50 (functional) = 0.5034 uM PubChem BioAssay. Dose response for HTS for Beta-2AR agonists via FAP method from Powderset1. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 6.606 um PUBCHEM_BIOASSAY: TR-FRET counterscreen for FAK inhibitors: dose-response biochemical high throughput screening assay to identify inhibitors of Proline-rich tyrosine kinase 2 (Pyk2). (Class of assay: confirmatory) [Related pubchem assays: 794, 727, 810 ] ChEMBL. No reference
IC50 (binding) < 10 uM Inhibition at EthR in Mycobacterium smegmatis mc2 155 assessed as reactivation of beta-glucuronidase activity measured over 48 hrs by Spectrophotometry ChEMBL. 22738293
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 1.2589 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 1.8349 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 4.6109 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 21.3313 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 125.8925 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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