Detailed information for compound 1363859

Basic information

Technical information
  • TDR Targets ID: 1363859
  • Name: 10-[(3-chlorophenyl)methyl]phenothiazine 5,5- dioxide
  • MW: 355.838 | Formula: C19H14ClNO2S
  • H donors: 0 H acceptors: 2 LogP: 4.6 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)CN1c2ccccc2S(=O)(=O)c2c1cccc2
  • InChi: 1S/C19H14ClNO2S/c20-15-7-5-6-14(12-15)13-21-16-8-1-3-10-18(16)24(22,23)19-11-4-2-9-17(19)21/h1-12H,13H2
  • InChiKey: WCSSLMYJENCAMG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 10-(3-chlorobenzyl)phenothiazine 5,5-dioxide
  • NCGC00129753-01
  • G233-0250

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) RNA binding protein 0.0076 0.0114 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0038 0.444
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0166 0.0304 0.0284
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0038 0.444
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0644 0.1314 0.1295
Chlamydia trachomatis biotin carboxylase 0.1644 0.3428 1
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0114 0.0098
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0166 0.0304 0.0425
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.181 0.378 0.378
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.181 0.378 1
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0166 0.0304 0.0425
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.0067 0.0038
Treponema pallidum pyruvate carboxylase subunit B 0.0166 0.0304 0.5
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.0166 0.0304 0.0304
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.0166 0.0304 0.0262
Toxoplasma gondii pyruvate carboxylase 0.181 0.378 0.3756
Schistosoma mansoni aspartate carbamoyltransferase 0.0409 0.0817 0.0798
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0114 0.0093
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.0166 0.0304 0.0268
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.181 0.378 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0067 1
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0644 0.1314 0.1281
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0166 0.0304 0.0294
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0114 0.0093
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0067 0.0049
Trypanosoma cruzi acetyl-CoA carboxylase 0.2942 0.6173 1
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.0166 0.0304 0.0268
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0114 0.0093
Onchocerca volvulus 0.0033 0.0021 0.5
Onchocerca volvulus 0.0033 0.0021 0.5
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.0067 0.0023
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0644 0.1314 0.2905
Brugia malayi RNA binding protein 0.0076 0.0114 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0038 0.444
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0644 0.1314 0.2072
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.0166 0.0304 0.0304
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0014 0.0018
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.181 0.378 0.3766
Loa Loa (eye worm) hypothetical protein 0.0166 0.0304 0.0295
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0038 0.444
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0166 0.0304 0.0284
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0644 0.1314 0.2905
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0044 0.556
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0166 0.0304 0.0284
Loa Loa (eye worm) hypothetical protein 0.0166 0.0304 0.0295
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.0166 0.0304 0.0262
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0014 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0029 0.2856
Mycobacterium ulcerans pyruvate carboxylase 0.181 0.378 1
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0166 0.0304 0.0294
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0166 0.0304 0.0284
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.4586 0.9648 1
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0644 0.1314 0.1314
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0038 0.444
Trypanosoma brucei unspecified product 0.119 0.2468 0.2468
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0027 0.2387
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0166 0.0304 0.0284
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0044 0.556
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0166 0.0304 0.0425
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0644 0.1314 0.1295
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0166 0.0304 0.0284
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0644 0.1314 0.2905
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0038 0.444
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0644 0.1314 0.2905
Echinococcus multilocularis Biotin lipoyl attachment 0.0166 0.0304 0.0284
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0114 0.0098
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0644 0.1314 0.1295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.005 0.6827
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.181 0.378 1
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0114 0.0096
Leishmania major carboxylase, putative 0.181 0.378 0.3752
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.0166 0.0304 0.0262
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0021 0.1267
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0644 0.1314 0.2905
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0409 0.0817 0.0817
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.0044 0.0044
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.0067 0.0046
Loa Loa (eye worm) hypothetical protein 0.0166 0.0304 0.0295
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.0166 0.0304 0.0268
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0044 0.556
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0114 0.0093
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0114 0.0093
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.181 0.378 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.0166 0.0304 0.0268
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0644 0.1314 0.2905
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0166 0.0304 0.0294
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0166 0.0304 0.0284
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0166 0.0304 0.0284
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0409 0.0817 0.1476
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.0067 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0021 0.1267
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0067 1
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0166 0.0304 0.0425
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.0067 0.0023
Entamoeba histolytica acetyl-coA carboxylase, putative 0.081 0.1666 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0067 0.0048
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.0067 0.0067
Trypanosoma brucei acetyl-CoA carboxylase 0.4752 1 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0021 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0044 0.556
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.0067 0.0067
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0409 0.0817 0.1262
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0409 0.0817 0.0742
Leishmania major carbamoyl-phosphate synthase, putative 0.0409 0.0817 0.0777
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0644 0.1314 0.2905
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0409 0.0817 0.1262
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0644 0.1314 0.1276
Plasmodium falciparum carbamoyl phosphate synthetase 0.0409 0.0817 0.0742
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.181 0.378 0.3752
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0644 0.1314 0.2905
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0021 0.0001
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.181 0.378 0.3766
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0644 0.1314 0.2072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.002 0.1138
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.4752 1 1
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0644 0.1314 0.2905
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0409 0.0817 0.1476
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0038 0.444
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0644 0.1314 0.2905
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.181 0.378 0.6095
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.181 0.378 0.6095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0021 0.1267
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0166 0.0304 0.0425
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.181 0.378 1
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0644 0.1314 0.2072
Echinococcus granulosus Biotin lipoyl attachment 0.0166 0.0304 0.0284
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.0067 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0044 0.556
Schistosoma mansoni pyruvate carboxylase 0.181 0.378 0.3766
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.3439 0.7223 1
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.181 0.378 0.3766
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0644 0.1314 0.1276
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0014 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0014 0.0018
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.181 0.378 0.3766
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0166 0.0304 0.0262
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0114 0.0093
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.0067 0.0038
Brugia malayi Carboxyl transferase domain containing protein 0.4586 0.9648 1
Leishmania major acetyl-CoA carboxylase, putative 0.4752 1 1
Toxoplasma gondii carbamoylphosphate synthetase 0.0409 0.0817 0.0783
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.4752 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0021 0.0001
Echinococcus granulosus tar DNA binding protein 0.0076 0.0114 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0067 1
Brugia malayi TAR-binding protein 0.0076 0.0114 0.0096
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.3439 0.7223 1
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.0166 0.0304 0.0304
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.181 0.378 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0026 0.0007 0.0007
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0644 0.1314 0.3233
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.4752 1 1
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0644 0.1314 0.2905
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.0166 0.0304 0.0304
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0166 0.0304 0.0268
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0409 0.0817 0.0798
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0409 0.0817 0.0798
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.002 0.1138
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.181 0.378 1
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.0166 0.0304 0.0425
Schistosoma mansoni acetyl-CoA carboxylase 0.4752 1 1
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.181 0.378 0.378
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.081 0.1666 1
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0166 0.0304 0.0425
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0644 0.1314 0.2905

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0079 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.14 uM PUBCHEM_BIOASSAY: IN Cell qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID493208] ChEMBL. No reference
Potency (functional) 5.8479 uM PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465] ChEMBL. No reference
Potency (binding) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 112.2018 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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