Detailed information for compound 1368625

Basic information

Technical information
  • TDR Targets ID: 1368625
  • Name: [5-acetamido-3-acetyloxy-2-(acetyloxymethyl)- 6-(4-formylphenoxy)oxan-4-yl] acetate
  • MW: 451.424 | Formula: C21H25NO10
  • H donors: 1 H acceptors: 5 LogP: 0.39 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=Cc1ccc(cc1)OC1OC(COC(=O)C)C(C(C1NC(=O)C)OC(=O)C)OC(=O)C
  • InChi: 1S/C21H25NO10/c1-11(24)22-18-20(30-14(4)27)19(29-13(3)26)17(10-28-12(2)25)32-21(18)31-16-7-5-15(9-23)6-8-16/h5-9,17-21H,10H2,1-4H3,(H,22,24)
  • InChiKey: FVQYHIYFHAVCLA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [5-acetamido-3-acetoxy-2-(acetoxymethyl)-6-(4-formylphenoxy)tetrahydropyran-4-yl] acetate
  • acetic acid [5-acetamido-3-acetoxy-2-(acetoxymethyl)-6-(4-formylphenoxy)-4-tetrahydropyranyl] ester
  • acetic acid [5-acetamido-3-acetoxy-2-(acetoxymethyl)-6-(4-formylphenoxy)tetrahydropyran-4-yl] ester
  • [5-acetamido-3-acetyloxy-2-(acetyloxymethyl)-6-(4-methanoylphenoxy)oxan-4-yl] ethanoate
  • BAS 00942873
  • TULIP028516
  • MLS000712098
  • SMR000281865
  • ChemDiv1_020558
  • Oprea1_557783
  • AG-690/12557752

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0022 0.0629
Echinococcus granulosus ATP binding cassette sub family G 0.006 0.033 0.033
Toxoplasma gondii histone lysine-specific demethylase 0.0023 0.0051 0.1159
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0022 0.0056
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0013 0.0035
Echinococcus multilocularis expressed conserved protein 0.0089 0.0548 0.0548
Schistosoma mansoni microtubule-associated protein tau 0.136 1 1
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.006 0.033 0.7699
Loa Loa (eye worm) hypothetical protein 0.0033 0.0125 0.0341
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0129 0.0347
Echinococcus multilocularis 0.0023 0.0051 0.0051
Echinococcus multilocularis Ankyrin 0.0056 0.0302 0.0302
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0509 0.3673 1
Leishmania major DNA polymerase eta, putative 0.0019 0.0022 0.0484
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0022 0.0629
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0021 0.0021
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0052 0.1548
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0143 1
Brugia malayi Doublecortin family protein 0.0039 0.0174 0.047
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0021 0.002
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0023 0.0051 0.0051
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0509 0.3673 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0021 0.002
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0001
Schistosoma mansoni amine oxidase 0.0023 0.0051 0.005
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0429 0.0429
Echinococcus granulosus TNFR CD27 30 40 95 cysteine rich region 0.0086 0.0522 0.0522
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0125 0.0341
Schistosoma mansoni hypothetical protein 0.0048 0.0243 0.0242
Echinococcus multilocularis expressed protein 0.0361 0.2566 0.2566
Loa Loa (eye worm) ABC transporter 0.0051 0.0262 0.0714
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.0591 0.0591
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0052 0.0085
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0056 0.0302 0.0821
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0021 0.0021
Onchocerca volvulus 0.0509 0.3673 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0231 0.5368
Brugia malayi Death domain containing protein 0.0056 0.0302 0.0818
Mycobacterium ulcerans hypothetical protein 0.0047 0.0231 0.0572
Loa Loa (eye worm) hypothetical protein 0.0047 0.0231 0.0628
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0022 0.0629
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0013 0.0032
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0022 0.0056
Brugia malayi hypothetical protein 0.0019 0.0021 0.0054
Schistosoma mansoni hypothetical protein 0.0039 0.0176 0.0175
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0429 0.0429
Echinococcus multilocularis netrin receptor unc 5 0.0056 0.0302 0.0302
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0052 0.1548
Onchocerca volvulus Netrin receptor homolog 0.0056 0.0302 0.0693
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0138
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0057
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0125 0.0338
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0052 0.0083
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0021 0.002
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0021 0.0021
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0021 0.0021
Brugia malayi MH2 domain containing protein 0.0144 0.0956 0.26
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.0591 0.0591
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0429 0.1164
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0022 0.0629
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0021 0.0021
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0021 0.0054
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0021 0.0021
Echinococcus granulosus lamin 0.0033 0.0125 0.0125
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0509 0.3673 1
Schistosoma mansoni lipoxygenase 0.0163 0.1098 0.1097
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0059
Loa Loa (eye worm) hypothetical protein 0.0047 0.0231 0.0628
Schistosoma mansoni patched 1 0.0041 0.0187 0.0186
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0056 0.0302 0.03
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0056 0.0302 0.0302
Schistosoma mansoni hypothetical protein 0.005 0.0257 0.0256
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0509 0.3673 1
Schistosoma mansoni hypothetical protein 0.0205 0.1406 0.1405
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0602 0.0601
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0021 0.0057
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0022 0.0059
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0429 0.1114
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0138
Echinococcus granulosus netrin receptor unc 5 0.0056 0.0302 0.0302
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0001 0.0003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0129 0.0347
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0429 1
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0021 0.0021
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.0591 0.1606
Echinococcus multilocularis microtubule associated protein 2 0.136 1 1
Schistosoma mansoni rab6-interacting 0.0039 0.0174 0.0173
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0138
Trypanosoma cruzi ABC transporter, putative 0.006 0.033 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0231 0.0572
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0125 0.0341
Loa Loa (eye worm) hypothetical protein 0.0035 0.0143 0.0389
Echinococcus multilocularis protein dispatched 1 0.0047 0.023 0.023
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0021 0.0021
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.0591 0.1561
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0052 0.5
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0051 0.1505
Echinococcus granulosus dna polymerase kappa 0.0019 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.005 0.0255 0.0695
Loa Loa (eye worm) hypothetical protein 0.0056 0.0302 0.0821
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.165 0.165
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0023 0.0051 0.005
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0231 0.0625
Loa Loa (eye worm) hypothetical protein 0.0041 0.0187 0.0508
Plasmodium falciparum protoporphyrinogen oxidase 0.0023 0.0051 0.1505
Schistosoma mansoni ap endonuclease 0.0023 0.0052 0.0051
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0023 0.0051 0.0079
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0231 0.0572
Brugia malayi PXA domain containing protein 0.0019 0.0021 0.0054
Onchocerca volvulus 0.0033 0.0125 0.0206
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0231 0.0572
Mycobacterium ulcerans dehydrogenase 0.0023 0.0051 0.0079
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0021 0.0021
Echinococcus multilocularis dna polymerase eta 0.0019 0.0022 0.0022
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0022 0.0629
Echinococcus multilocularis lamin dm0 0.0033 0.0125 0.0125
Mycobacterium ulcerans monoamine oxidase 0.0023 0.0051 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0022 0.0629
Echinococcus granulosus death domain containing protein 0.0056 0.0302 0.0302
Brugia malayi intermediate filament protein 0.0033 0.0125 0.0338
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0509 0.3673 1
Brugia malayi hypothetical protein 0.0118 0.0764 0.2077
Giardia lamblia ABC transporter 0.0059 0.0325 0.0831
Brugia malayi SWIRM domain containing protein 0.0023 0.0051 0.0135
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0021 0.0057
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0138
Brugia malayi hypothetical protein 0.0023 0.0051 0.0135
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0022 0.0021
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0234 0.1622 0.1622
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0231 0.5368
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0021 0.0054
Echinococcus granulosus RUN 0.0039 0.0174 0.0174
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0052 0.5
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0021 0.0054
Schistosoma mansoni hypothetical protein 0.0039 0.0174 0.0173
Onchocerca volvulus 0.0048 0.0243 0.0532
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0174 0.0174
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0052 0.0139
Onchocerca volvulus 0.0047 0.0231 0.0497
Onchocerca volvulus Huntingtin homolog 0.0118 0.0764 0.1969
Plasmodium vivax ABC transporter G family member 2, putative 0.006 0.033 1
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.006 0.033 0.7699
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0052 0.0139
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0057
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0051 0.0135
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0052 0.1548
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0138
Brugia malayi hypothetical protein 0.0039 0.0174 0.047
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0021 0.0021
Schistosoma mansoni netrin receptor unc5 0.0056 0.0302 0.03
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0429 1
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0297 0.2095 0.5703
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0022 0.0629
Schistosoma mansoni polycystin 1-related 0.0039 0.0174 0.0173
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0023 0.0051 0.1505
Loa Loa (eye worm) hypothetical protein 0.0035 0.0143 0.0389
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0023 0.0051 0.1505
Schistosoma mansoni hypothetical protein 0.0039 0.0176 0.0175
Echinococcus granulosus Ankyrin 0.0056 0.0302 0.0302
Schistosoma mansoni lamin 0.0033 0.0125 0.0124
Schistosoma mansoni hypothetical protein 0.0056 0.0302 0.03
Plasmodium falciparum ABC transporter G family member 2 0.006 0.033 1
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0509 0.3673 1
Echinococcus granulosus expressed protein 0.0361 0.2566 0.2566
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.006 0.033 0.0845
Schistosoma mansoni rab6-interacting 0.0039 0.0174 0.0173
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0231 0.0574
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0143 0.0386
Loa Loa (eye worm) hypothetical protein 0.0035 0.0143 0.0389
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0052 0.0052
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0052 0.1548
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0118 0.0764 0.2079
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0022 0.0629
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0143 0.4303
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0021 0.002
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.0895 0.0895
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.032 0.2263 0.6138
Schistosoma mansoni ABC transporter 0.0051 0.0262 0.0261
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0001
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0001 0.0001
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0231 0.0572
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0021 0.0054
Trypanosoma cruzi ATP-binding cassette protein, putative 0.006 0.033 1
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0021 0.0021
Echinococcus multilocularis ATP binding cassette sub family G 0.006 0.033 0.033
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0022 0.0629
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0022 0.0629
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0231 0.0625
Echinococcus granulosus tumor necrosis factor receptor superfamily 0.0086 0.0522 0.0522
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0509 0.3673 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0956 0.2602
Leishmania major DNA polymerase kappa, putative 0.0019 0.0022 0.0484
Loa Loa (eye worm) hypothetical protein 0.0237 0.165 0.4492
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0231 1
Trypanosoma brucei ABC transporter, putative 0.006 0.033 1
Trypanosoma brucei ATP-binding cassette protein, putative 0.006 0.033 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0056 0.0302 0.0818
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.0895 0.0895
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0231 0.0572
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0052 0.1192
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0022 0.0629
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0231 0.0574
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0022 0.0629
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0021 0.0054
Echinococcus multilocularis lamin 0.0033 0.0125 0.0125
Echinococcus multilocularis ATP binding cassette sub family G 0.006 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0118 0.0764 0.2079
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0022 0.0629
Echinococcus multilocularis ATP binding cassette sub family G 0.006 0.033 0.033
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0021 0.002
Mycobacterium tuberculosis Possible oxidoreductase 0.0023 0.0051 0.0135
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0021 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0187 0.0454
Entamoeba histolytica ABC transporter, putative 0.006 0.033 0.0847
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0052 0.0085
Echinococcus multilocularis RUN 0.0039 0.0174 0.0174
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0052 0.0083
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0021 0.0057
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0231 0.5368
Echinococcus multilocularis tumor necrosis factor receptor superfamily 0.0086 0.0522 0.0522
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0021 0.002
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0174 0.0473
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0143 0.0331
Loa Loa (eye worm) hypothetical protein 0.0035 0.0143 0.0389
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0021 0.002
Echinococcus multilocularis protoporphyrinogen oxidase 0.0023 0.0051 0.0051
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0052 0.1548
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0001
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0138
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0022 0.0056
Schistosoma mansoni survival motor neuron protein 0.0048 0.0243 0.0242
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0021 0.0057
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0231 0.0572
Onchocerca volvulus 0.0039 0.0174 0.034
Echinococcus multilocularis musashi 0.0033 0.0125 0.0125
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0023 0.0051 0.1159
Brugia malayi amine oxidase, flavin-containing family protein 0.0023 0.0051 0.0135
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0022 0.0629
Loa Loa (eye worm) hypothetical protein 0.0056 0.0302 0.0821
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0143 0.4303
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.006 0.033 0.0845
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0174 0.0174
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0051 0.1505
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0022 0.0629
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0001 0.0001
Echinococcus granulosus geminin 0.0205 0.1406 0.1406
Trypanosoma cruzi UDP-galactopyranose mutase 0.0023 0.0051 0.1505
Onchocerca volvulus 0.0039 0.0174 0.034
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0174 0.0174
Echinococcus granulosus intermediate filament protein 0.0033 0.0125 0.0125
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0509 0.3673 1
Trypanosoma brucei unspecified product 0.0019 0.0022 0.0629
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.006 0.033 0.0845
Brugia malayi hypothetical protein 0.0019 0.0021 0.0054
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0174 0.0174
Echinococcus granulosus lysine specific histone demethylase 1A 0.0023 0.0051 0.0051
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0231 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.0023 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0057
Onchocerca volvulus 0.0033 0.0125 0.0206
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0052 0.0085
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0231 0.0625
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0509 0.3673 1
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0021 0.0021
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0174 0.0174
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0022 0.0003
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0022 0.0003
Echinococcus multilocularis TNFR CD27 30 40 95 cysteine rich region 0.0086 0.0522 0.0522
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0187 0.0187
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0429 0.1114
Brugia malayi Protein kinase domain containing protein 0.0056 0.0302 0.0818
Echinococcus granulosus lamin dm0 0.0033 0.0125 0.0125
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0056 0.0302 0.0302
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0022 0.0629
Loa Loa (eye worm) hypothetical protein 0.0047 0.0231 0.0628
Schistosoma mansoni hypothetical protein 0.0039 0.0176 0.0175
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0057
Loa Loa (eye worm) hypothetical protein 0.0039 0.0174 0.0473
Plasmodium vivax multidomain scavenger receptor, putative 0.0039 0.0174 0.5243
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0022 0.0021
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0174 0.0174
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0022 0.0022
Echinococcus multilocularis geminin 0.0205 0.1406 0.1406
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0231 0.0574
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0022 0.0484
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0231 0.0572
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0021 0.0057
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0509 0.3673 1
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0021 0.002
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0509 0.3673 1
Leishmania major UDP-galactopyranose mutase 0.0023 0.0051 0.1159
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0022 0.0629
Trypanosoma cruzi UDP-galactopyranose mutase 0.0023 0.0051 0.1505
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0509 0.3673 1
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0956 0.2602
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0429 0.0428
Brugia malayi PXA domain containing protein 0.0019 0.0021 0.0054
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0057
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0243 0.066
Brugia malayi hypothetical protein 0.0039 0.0174 0.047
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0021 0.0021
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0023 0.0051 0.1505
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0429 0.0428
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0021 0.0054
Brugia malayi Uncoordinated protein 44 0.0056 0.0302 0.0818
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.032 0.2263 0.6138
Schistosoma mansoni DNA polymerase eta 0.0019 0.0022 0.0021
Echinococcus granulosus ATP binding cassette sub family G 0.006 0.033 0.033
Schistosoma mansoni lamin 0.0033 0.0125 0.0124
Brugia malayi ABC transporter family protein 0.0051 0.0262 0.0711
Echinococcus granulosus dna polymerase eta 0.0019 0.0022 0.0022
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter 0.005 0.0257 0.0697
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.165 0.165
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0129 0.0347
Brugia malayi hypothetical protein 0.0237 0.165 0.449
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0231 0.0625
Loa Loa (eye worm) hypothetical protein 0.0039 0.0174 0.0473
Loa Loa (eye worm) hypothetical protein 0.0035 0.0143 0.0389
Schistosoma mansoni hypothetical protein 0.0039 0.0176 0.0175
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0021 0.0021
Schistosoma mansoni ap endonuclease 0.0023 0.0052 0.0051
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0022 0.0056
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0021 0.002
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0021 0.0021
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0021 0.002
Onchocerca volvulus Huntingtin homolog 0.0118 0.0764 0.1969
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0021 0.002
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0021 0.0021
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.006 0.033 0.7699
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0052 0.0052
Schistosoma mansoni intermediate filament proteins 0.0033 0.0125 0.0124
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0509 0.3673 1
Schistosoma mansoni loxhd1 0.0039 0.0174 0.0173
Echinococcus granulosus ATP binding cassette sub family G 0.006 0.033 0.033
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0234 0.1622 0.1622
Toxoplasma gondii exonuclease III APE 0.0023 0.0052 0.1192
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0022 0.0629
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0021 0.0021
Schistosoma mansoni lipoxygenase 0.0234 0.1622 0.1621
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0022 0.0629
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0429 0.1114
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0231 0.0625
Brugia malayi CHE-14 protein 0.0041 0.0187 0.0506
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0022 0.0003
Loa Loa (eye worm) hypothetical protein 0.0095 0.0591 0.1608
Schistosoma mansoni amine oxidase 0.0023 0.0051 0.005
Schistosoma mansoni hypothetical protein 0.0205 0.1406 0.1405
Echinococcus multilocularis protein patched 0.0041 0.0187 0.0187
Echinococcus granulosus expressed conserved protein 0.0089 0.0548 0.0548
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0023 0.0051 0.005
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0187 0.0187
Schistosoma mansoni tumor necrosis factor receptor related 0.0086 0.0522 0.0521
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0057
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.006 0.033 0.0329
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0021 0.0021
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0129 0.0347
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0052 0.0142
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0022 0.0022
Mycobacterium ulcerans oxidoreductase 0.0023 0.0051 0.0079
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.0051 0.1505
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0187 0.0187
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0187 0.0508
Schistosoma mansoni ankyrin 23/unc44 0.0056 0.0302 0.03
Plasmodium falciparum LCCL domain-containing protein 0.0039 0.0174 0.5243
Loa Loa (eye worm) hypothetical protein 0.0032 0.0121 0.0329

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0007 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.2818 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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