Detailed information for compound 137273

Basic information

Technical information
  • TDR Targets ID: 137273
  • Name: 2-cyclohexylsulfanyl-6-[1-(2,6-difluorophenyl )ethyl]-1H-pyrimidin-4-one
  • MW: 350.426 | Formula: C18H20F2N2OS
  • H donors: 1 H acceptors: 3 LogP: 5.32 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1cc(nc(n1)SC1CCCCC1)C(c1c(F)cccc1F)C
  • InChi: 1S/C18H20F2N2OS/c1-11(17-13(19)8-5-9-14(17)20)15-10-16(23)22-18(21-15)24-12-6-3-2-4-7-12/h5,8-12H,2-4,6-7H2,1H3,(H,21,22,23)
  • InChiKey: CYLJSOXMKZQFQS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(cyclohexylthio)-6-[1-(2,6-difluorophenyl)ethyl]-1H-pyrimidin-4-one
  • AIDS-111282
  • AIDS111282
  • 4(3H)-Pyrimidinone, 2-(cyclohexylthio)-6-[1-(2,6-difluorophenyl)ethyl]-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0039 0.0036
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0018 0.0024 0.0037
Schistosoma mansoni carbonic anhydrase-related 0.0174 0.0434 0.1045
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0024 0.0037
Schistosoma mansoni hypothetical protein 0.0038 0.0078 0.0182
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0038 0.0076 0.0118
Loa Loa (eye worm) hypothetical protein 0.0038 0.0076 0.0629
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0012 0.0008 0.0066
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0083 0.0194 0.4435
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0024 0.0127
Loa Loa (eye worm) hypothetical protein 0.0053 0.0116 0.0958
Schistosoma mansoni ap endonuclease 0.002 0.003 0.0066
Brugia malayi nuclear receptor RXR 0.0018 0.0024 0.019
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0039 0.0075
Schistosoma mansoni hypothetical protein 0.004 0.0083 0.0194
Loa Loa (eye worm) oxidoreductase 0.0012 0.0008 0.0066
Brugia malayi Probable ClpP-like protease 0.0083 0.0194 0.1601
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.015 0.037 0.0574
Leishmania major trypanothione reductase 0.0075 0.0175 0.0404
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0262 0.0259
Echinococcus granulosus microtubule associated protein 2 0.0736 0.191 1
Echinococcus granulosus nuclear receptor nhr 48 0.0018 0.0024 0.0124
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.003 0.0056 0.0465
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0026 0.0046 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0038 0.0076 0.0623
Trypanosoma brucei ingi protein (ORF1) 0.0029 0.0053 0.0418
Chlamydia trachomatis sulfate transporter 0.0102 0.0245 0.563
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.003 0.0046
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0038 0.0076 0.0397
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0243
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0008 0.0005
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0066 0.0151 0.0347
Leishmania major carbonic anhydrase family protein, putative 0.1582 0.413 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0026 0.0046 0.0238
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0018 0.0024 0.0051
Schistosoma mansoni cpg binding protein 0.0028 0.0051 0.0117
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0038 0.0076 0.0118
Plasmodium falciparum thioredoxin reductase 0.0026 0.0046 0.0994
Entamoeba histolytica hypothetical protein 0.0038 0.0078 0.0182
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0012 0.0008 0.0042
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0026 0.0046 0.0043
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0026 0.0046 0.0071
Leishmania major ribonuclease H1, putative 0.0027 0.0047 0.0095
Echinococcus multilocularis survival motor neuron protein 1 0.0252 0.0639 0.0992
Echinococcus multilocularis ecdysone induced protein 78C 0.0038 0.0076 0.0118
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0039 0.0036
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0008 0.006
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0039 0.0314
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0233 0.0558
Echinococcus multilocularis FTZ F1 alpha 0.0038 0.0076 0.0118
Leishmania major carbonic anhydrase-like protein 0.0469 0.1208 0.291
Mycobacterium ulcerans carbonic anhydrase 0.1582 0.413 0.4129
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0046 0.0356
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0012 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0196
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0118 0.0116
Schistosoma mansoni ap endonuclease 0.002 0.003 0.0066
Echinococcus granulosus geminin 0.0513 0.1323 0.6925
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0019 0.0027 0.0221
Mycobacterium leprae Probable transmembrane transport protein 0.0739 0.1916 0.4636
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0173 0.0432 0.1041
Echinococcus granulosus FTZ F1 alpha 0.0038 0.0076 0.0397
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0078 0.0121
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0066
Brugia malayi MH2 domain containing protein 0.0016 0.002 0.0158
Mycobacterium tuberculosis Probable oxidoreductase 0.0191 0.0478 0.059
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0046 0.0356
Schistosoma mansoni carbonic anhydrase 0.0174 0.0434 0.1045
Brugia malayi photoreceptor-specific nuclear receptor 0.0038 0.0076 0.0623
Echinococcus granulosus GPCR family 2 0.0064 0.0144 0.0756
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0012 0.0008 0.0012
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0008 0.0005
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0039 0.0314
Trypanosoma brucei carbonic anhydrase-like protein 0.0469 0.1208 1
Plasmodium falciparum enoyl-acyl carrier reductase 0.0173 0.0432 0.9961
Mycobacterium ulcerans putative regulatory protein 0.0084 0.0198 0.0195
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0039 0.0087
Echinococcus multilocularis nuclear receptor nhr 48 0.0018 0.0024 0.0037
Loa Loa (eye worm) nuclear factor I 0.0009 0.0001 0.0006
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0026 0.0046 0.0091
Brugia malayi hypothetical protein 0.001 0.0003 0.0016
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.1582 0.413 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0021 0.0016
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0083 0.0194 0.1016
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0008 0.0005
Brugia malayi acetyltransferase, GNAT family protein 0.015 0.037 0.3057
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0026 0.0046 0.0356
Chlamydia trachomatis oxoacy-ACP reductase 0.0012 0.0008 0.0122
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0024 0.0124
Schistosoma mansoni hypothetical protein 0.0513 0.1323 0.3198
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0078 0.0182
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0191
Onchocerca volvulus 0.0085 0.02 0.1191
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0166 0.0163
Toxoplasma gondii ABC1 family protein 0.0072 0.0166 0.378
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0022
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0243
Trypanosoma cruzi polo-like protein kinase, putative 0.0109 0.0262 0.2153
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0166 0.3795
Mycobacterium ulcerans lipase LipD 0.0072 0.0166 0.0163
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0144 0.119
Echinococcus granulosus replication factor c subunit 1 0.001 0.0003 0.0014
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0052 0.1144
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0021 0.0016
Brugia malayi ecdysone receptor 0.0018 0.0024 0.019
Entamoeba histolytica carbonic anhydrase, putative 0.1582 0.413 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0196
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0066 0.0151 0.1231
Schistosoma mansoni thyroid hormone receptor 0.0038 0.0076 0.0177
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0173 0.0432 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0076 0.0629
Toxoplasma gondii NADPH-glutathione reductase 0.0026 0.0046 0.0994
Loa Loa (eye worm) hypothetical protein 0.0201 0.0506 0.4188
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0469 0.1208 0.2919
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0023 0.0474
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0008 0.0005
Onchocerca volvulus Bile acid receptor homolog 0.0038 0.0076 0.0443
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0008 0.0005
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0026 0.0046 0.0091
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0039 0.0314
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0021 0.0016
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0023 0.0019
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0026 0.0046 0.0998
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0076 0.0623
Mycobacterium ulcerans hypothetical protein 0.0072 0.0166 0.0163
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0026 0.0046 0.0356
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0038 0.0076 0.0629
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0174 0.0434 0.359
Echinococcus multilocularis thioredoxin glutathione reductase 0.0076 0.0177 0.0275
Schistosoma mansoni retinoic acid receptor RXR 0.0038 0.0076 0.0177
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0166 0.0198
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0026 0.0046 0.0356
Loa Loa (eye worm) hypothetical protein 0.0038 0.0076 0.0629
Mycobacterium tuberculosis Conserved protein 0.0072 0.0166 0.0198
Brugia malayi MH2 domain containing protein 0.0016 0.002 0.0158
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0116 0.0274
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0003 0.00000022179
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0012 0.0008 0.0044
Trichomonas vaginalis hypothetical protein 0.0173 0.0432 0.043
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.0072 0.0166 0.1372
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0026 0.0046 0.0356
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0018 0.0024 0.0196
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0038 0.0076 0.0623
Echinococcus granulosus carbonic anhydrase 0.0174 0.0434 0.2272
Echinococcus granulosus survival motor neuron protein 1 0.0252 0.0639 0.3348
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0024 0.0124
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.002 0.0031
Schistosoma mansoni hypothetical protein 0.0513 0.1323 0.3198
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0054 0.0119 0.014
Schistosoma mansoni nuclear receptor 0.0018 0.0024 0.0051
Echinococcus granulosus thioredoxin glutathione reductase 0.0076 0.0177 0.0928
Brugia malayi hypothetical protein 0.002 0.0029 0.0237
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0196
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0012 0.0008 0.0122
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0109 0.0262 0.0617
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0024 0.0037
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0024 0.019
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0003 0.00000022179
Brugia malayi hypothetical protein 0.0181 0.0452 0.3738
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0196
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0012 0.0008 0.0013
Schistosoma mansoni carbonic anhydrase-related 0.0174 0.0434 0.1045
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.1511 0.3942 0.4939
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0018 0.0024 0.0037
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0166 0.0163
Onchocerca volvulus Protein ultraspiracle homolog 0.0038 0.0076 0.0443
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0038 0.0076 0.0623
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0739 0.1916 0.2396
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0166 0.0395
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.003 0.0247
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0191
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0003 0.00000053718
Mycobacterium tuberculosis Probable reductase 0.0172 0.0428 0.0527
Loa Loa (eye worm) hypothetical protein 0.0051 0.0112 0.0924
Schistosoma mansoni phosphoglucomutase 0.0027 0.0047 0.0108
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0022
Schistosoma mansoni hypothetical protein 0.0138 0.0338 0.0814
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0046 0.0356
Brugia malayi hypothetical protein 0.002 0.0029 0.0237
Mycobacterium ulcerans epoxide hydrolase EphA 0.017 0.0423 0.0421
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0083 0.1861
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0026 0.0046 0.0994
Brugia malayi orphan nuclear receptor NR2E1 0.0018 0.0024 0.019
Loa Loa (eye worm) nuclear hormone receptor 0.0018 0.0024 0.0196
Loa Loa (eye worm) retinol dehydrogenase 12 0.0012 0.0008 0.0066
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0076 0.0623
Entamoeba histolytica hypothetical protein 0.0038 0.0078 0.0182
Mycobacterium leprae Possible regulatory protein 0.003 0.0055 0.0126
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0066 0.0151 0.079
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.002 0.0042
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0038 0.0076 0.0118
Loa Loa (eye worm) hypothetical protein 0.0072 0.0166 0.1372
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0102 0.0245 0.5608
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0174 0.0434 0.359
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.002 0.0104
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0166 0.0198
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0026 0.0046 0.0104
Onchocerca volvulus 0.064 0.1656 1
Loa Loa (eye worm) beta-lactamase 0.0072 0.0166 0.1372
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0012 0.0008 0.0044
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0022
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0166 0.0163
Schistosoma mansoni cpg binding protein 0.003 0.0055 0.0128
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0026 0.0046 0.0043
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0003 0.00000053718
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0026 0.0046 0.0047
Plasmodium falciparum glutathione reductase 0.0026 0.0046 0.0994
Echinococcus multilocularis carbonic anhydrase 0.0174 0.0434 0.0673
Brugia malayi MH1 domain containing protein 0.0016 0.002 0.0158
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0469 0.1208 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0144 0.0756
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0469 0.1208 1
Brugia malayi steroid hormone receptor 0.0038 0.0076 0.0623
Brugia malayi hypothetical protein 0.0252 0.0639 0.5293
Trypanosoma brucei unspecified product 0.0029 0.0053 0.0418
Plasmodium falciparum glutathione reductase 0.0075 0.0175 0.3986
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0166 0.0163
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.015 0.037 0.0889
Schistosoma mansoni smad1 5 8 and 0.0016 0.002 0.0042
Brugia malayi MH1 domain containing protein 0.0016 0.002 0.0158
Plasmodium vivax glutathione reductase, putative 0.0075 0.0175 0.4002
Trichomonas vaginalis glutathione reductase, putative 0.0026 0.0046 0.0043
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0166 0.0395
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0083 0.0194 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0087 0.0135
Brugia malayi tailless protein 0.0018 0.0024 0.019
Schistosoma mansoni zinc finger protein 0.0018 0.0024 0.0051
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.002 0.0029 0.0045
Echinococcus multilocularis cpg binding protein 0.003 0.0055 0.0086
Echinococcus multilocularis ribonuclease H1 0.0027 0.0047 0.0073
Schistosoma mansoni hypothetical protein 0.0174 0.0434 0.1045
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.003 0.0053
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.0076 0.0177
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0196
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0076 0.0623
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0144 0.1196
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0026 0.0046 0.0043
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0038 0.0076 0.0177
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0038 0.0076 0.0623
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0006
Echinococcus multilocularis tumor protein p63 0.0361 0.0924 0.1433
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0039 0.0087
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0003 0.0016
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0026 0.0046 0.0998
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.003 0.0027
Treponema pallidum ribonuclease H (rnhA) 0.0027 0.0047 0.2322
Schistosoma mansoni survival motor neuron protein 0.0051 0.0112 0.0265
Brugia malayi hypothetical protein 0.0038 0.0078 0.0639
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0022
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0083 0.0194 0.4453
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0166 0.0257
Schistosoma mansoni phosphoglucomutase 0.0027 0.0047 0.0108
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0026 0.0046 0.0371
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0012 0.0008 0.0005
Brugia malayi Nuclear hormone receptor E75 0.0018 0.0024 0.019
Loa Loa (eye worm) hypothetical protein 0.0123 0.0301 0.249
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0008 0.006
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0054 0.0119 0.0282
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0243
Giardia lamblia Kinase, PLK 0.0109 0.0262 1
Echinococcus granulosus Smad4 0.0016 0.002 0.0104
Loa Loa (eye worm) hypothetical protein 0.0023 0.0039 0.032
Schistosoma mansoni nuclear receptor 0.0018 0.0024 0.0051
Onchocerca volvulus 0.0038 0.0076 0.0443
Schistosoma mansoni hypothetical protein 0.004 0.0083 0.0194
Trichomonas vaginalis mercuric reductase, putative 0.0026 0.0046 0.0043
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0039 0.0036
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0066 0.0151 0.125
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0093 0.009
Brugia malayi beta-lactamase family protein 0.0072 0.0166 0.1367
Schistosoma mansoni nuclear receptor nhr-48 0.0018 0.0024 0.0051
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0196
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0012 0.0008 0.0005
Onchocerca volvulus 0.0018 0.0024 0.0127
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0029 0.0053 0.0418
Trypanosoma cruzi trypanothione reductase, putative 0.0075 0.0175 0.1427
Trichomonas vaginalis ribonuclease H1, putative 0.0027 0.0047 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.3819 1 1
Brugia malayi hypothetical protein 0.0018 0.0024 0.019
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0026 0.0046 0.0998
Leishmania major protein kinase, putative 0.003 0.0056 0.0116
Schistosoma mansoni hypothetical protein 0.0064 0.0144 0.0343
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0038 0.0076 0.0623
Echinococcus granulosus expressed conserved protein 0.0092 0.0217 0.1138
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0066 0.0151 0.0148
Loa Loa (eye worm) nuclear receptor NHR-67 0.0018 0.0024 0.0196
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0243
Mycobacterium tuberculosis Conserved protein 0.0072 0.0166 0.0198
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0201 0.0506 0.4188
Onchocerca volvulus 0.0053 0.0116 0.0683
Trichomonas vaginalis guanylate cyclase, putative 0.003 0.0055 0.0052
Trypanosoma cruzi ribonuclease H1, putative 0.0027 0.0047 0.0369
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.003 0.0055 0.0052
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0029 0.0237
Brugia malayi nuclear receptor RXR 0.002 0.0029 0.0237
Brugia malayi DKFZp564C0469 protein 0.001 0.0003 0.0016
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0144 0.0756
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0233 0.1219
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0066 0.0151 0.0359
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.003 0.0055 0.0052
Schistosoma mansoni thyroid hormone receptor 0.0038 0.0076 0.0177
Brugia malayi Smad1 0.0016 0.002 0.0158
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0038 0.0076 0.0177
Loa Loa (eye worm) hypothetical protein 0.0174 0.0434 0.3594
Brugia malayi PAS domain containing protein 0.0114 0.0276 0.2279
Onchocerca volvulus Serine\/threonine kinase homolog 0.0109 0.0262 0.1569
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0262 0.0259
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0038 0.0076 0.0177
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0191
Echinococcus multilocularis thyroid hormone receptor alpha 0.0038 0.0076 0.0118
Brugia malayi nuclear hormone receptor family member odr-7 0.0018 0.0024 0.019
Loa Loa (eye worm) carbonic anhydrase 3 0.0469 0.1208 1
Schistosoma mansoni hypothetical protein 0.0051 0.0112 0.0265
Brugia malayi ecdysteroid receptor 0.0038 0.0076 0.0623
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0038 0.0076 0.0629
Loa Loa (eye worm) hypothetical protein 0.0023 0.0039 0.032
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0083 0.0194 0.4453
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0008 0.0005
Brugia malayi bHLH-PAS transcription factor 0.0084 0.0198 0.1636
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0023 0.0476
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0262 0.0259
Schistosoma mansoni hypothetical protein 0.004 0.0083 0.0194
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0012 0.0008 0.0122
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.003 0.0241
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0038 0.0076 0.0397
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.0072 0.0166 0.1372
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0174 0.0434 0.3594
Brugia malayi hypothetical protein 0.0018 0.0024 0.019
Brugia malayi glutathione reductase 0.0075 0.0175 0.1441
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0166 0.0198
Echinococcus granulosus nibrin 0.001 0.0003 0.0014
Schistosoma mansoni smad1 5 8 and 0.0016 0.002 0.0042
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0083 0.0194 0.4453
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.003 0.0056 0.044
Schistosoma mansoni hypothetical protein 0.01 0.024 0.0574
Loa Loa (eye worm) hypothetical protein 0.0038 0.0076 0.0629
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0076 0.0623
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0012 0.0008 0.0013
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0075 0.0175 0.0209
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0039 0.0087
Echinococcus granulosus thyroid hormone receptor alpha 0.0018 0.0024 0.0124
Trypanosoma brucei trypanothione reductase 0.0075 0.0175 0.1427
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0196
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0166 0.0198
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0038 0.0076 0.0177
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0196
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.003 0.0056 0.0087
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0066 0.0151 0.3438
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0052 0.1139
Trichomonas vaginalis ap endonuclease, putative 0.002 0.003 0.0027
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0008 0.0005
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0191 0.0478 0.059
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0003 0.00000022179
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.003 0.0631
Loa Loa (eye worm) hypoxia-induced factor 1 0.0151 0.0374 0.3099
Loa Loa (eye worm) glutathione reductase 0.0075 0.0175 0.1446
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0166 0.1372
Trypanosoma brucei ribonuclease H1 0.0027 0.0047 0.0369
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0022
Plasmodium falciparum carbonic anhydrase 0.0174 0.0434 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0166 0.1372
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0173 0.0432 0.043
Echinococcus multilocularis expressed conserved protein 0.0092 0.0217 0.0337
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0039 0.0036
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0469 0.1208 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0201 0.0506 0.4185
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.003 0.0055 0.0432
Loa Loa (eye worm) hypothetical protein 0.0181 0.0452 0.3742
Brugia malayi CHE-14 protein 0.0042 0.0087 0.0713
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0038 0.0076 0.0629
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0039 0.0039
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0144 0.0224
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0039 0.0039
Entamoeba histolytica serine/threonine protein kinase, putative 0.0109 0.0262 0.0628
Brugia malayi hypothetical protein 0.001 0.0003 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0076 0.0623
Echinococcus granulosus carbonic anhydrase II 0.0469 0.1208 0.6322
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0066 0.0151 0.1245
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0012 0.0008 0.0005
Schistosoma mansoni microtubule-associated protein tau 0.0736 0.191 0.4621
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0076 0.0623
Echinococcus multilocularis carbonic anhydrase 0.0174 0.0434 0.0673
Brugia malayi MH2 domain containing protein 0.0239 0.0605 0.5003
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0166 0.0198
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0018 0.0024 0.0051
Schistosoma mansoni patched 1 0.0042 0.0087 0.0204
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0024 0.0051
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0053 0.0418
Brugia malayi nuclear receptor NHR-88 0.0038 0.0076 0.0623
Echinococcus multilocularis smad 0.0016 0.002 0.0031
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0102 0.0245 0.2008
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0012 0.0008 0.0005
Echinococcus granulosus carbonic anhydrase 0.0174 0.0434 0.2272
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0172 0.0428 0.0527
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0172 0.0428 0.103
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0196
Trypanosoma brucei ingi protein (ORF1) 0.0029 0.0053 0.0418
Trichomonas vaginalis conserved hypothetical protein 0.3819 1 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0237 0.0567
Brugia malayi latrophilin 2 splice variant baaae 0.0138 0.0338 0.2799
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0012 0.0008 0.0005
Echinococcus multilocularis GPCR, family 2 0.0064 0.0144 0.0224
Schistosoma mansoni steroid hormone receptor ad4bp 0.0038 0.0076 0.0177
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0066 0.0151 0.1231
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.003 0.0225
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0003 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0038 0.0076 0.0623
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0123 0.0299 0.2474
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0172 0.0428 0.0527
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.003 0.0066
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0012 0.0008 0.0122
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.003 0.0056 0.044
Echinococcus multilocularis carbonic anhydrase 0.0174 0.0434 0.0673
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0066 0.0151 0.0234
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0046 0.0356
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.003 0.1417
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.003 0.0055 0.1211
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0038 0.0076 0.0443
Echinococcus multilocularis protein patched 0.0042 0.0087 0.0135
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0093 0.0485
Brugia malayi CXXC zinc finger family protein 0.0028 0.0051 0.0417
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0038 0.0076 0.0397
Brugia malayi nuclear receptor NHR-67 0.0018 0.0024 0.019
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0021 0.0016
Onchocerca volvulus 0.0072 0.0166 0.0986
Trichomonas vaginalis ap endonuclease, putative 0.002 0.003 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0038 0.0076 0.0629
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0166 0.0163
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0066 0.0151 0.1245
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0026 0.0046 0.0356
Brugia malayi beta-lactamase family protein 0.0072 0.0166 0.1367
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0174 0.0434 0.359
Loa Loa (eye worm) steroid hormone receptor 0.0038 0.0076 0.0629
Echinococcus multilocularis carbonic anhydrase II 0.0469 0.1208 0.1874
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0173 0.0432 1
Onchocerca volvulus 0.0028 0.0051 0.0293
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0083 0.0194 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0055 0.0052
Onchocerca volvulus 0.0023 0.0039 0.0218
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.002 0.0029 0.0065
Brugia malayi nuclear receptor NHR-88 0.0018 0.0024 0.019
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0012 0.0008 0.0013
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0029 0.0065
Schistosoma mansoni Smad4 0.0016 0.002 0.0042
Echinococcus multilocularis aryl hydrocarbon receptor 0.0153 0.0378 0.0587
Onchocerca volvulus 0.0051 0.0112 0.0662
Plasmodium vivax thioredoxin reductase, putative 0.0075 0.0175 0.4002
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0166 0.1353
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0012 0.0008 0.0122
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0469 0.1208 1
Trypanosoma cruzi ribonuclease H1, putative 0.0027 0.0047 0.0369
Onchocerca volvulus 0.0072 0.0166 0.0986
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0083 0.3094
Toxoplasma gondii ribonuclease HI protein 0.0027 0.0047 0.103
Loa Loa (eye worm) hypothetical protein 0.0072 0.0166 0.1372
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0008 0.0005
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0076 0.0118
Brugia malayi Calcitonin receptor-like protein seb-1 0.0201 0.0506 0.4185
Schistosoma mansoni carbonic anhydrase-related 0.0174 0.0434 0.1045
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0174 0.0434 0.359
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0076 0.0397
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0191 0.0478 0.059
Plasmodium vivax sulfate transporter, putative 0.0102 0.0245 0.563
Trypanosoma cruzi trypanothione reductase, putative 0.0026 0.0046 0.0356
Trichomonas vaginalis esterase, putative 0.0072 0.0166 0.0163
Echinococcus granulosus smad 0.0016 0.002 0.0104
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0026 0.0046 0.0998
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0112 0.0924
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0166 0.0395
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0039 0.0036
Schistosoma mansoni single-minded 0.0114 0.0276 0.0662
Treponema pallidum NADH oxidase 0.0026 0.0046 0.2241
Echinococcus granulosus cpg binding protein 0.003 0.0055 0.029
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0469 0.1208 1
Brugia malayi RNase H family protein 0.0027 0.0047 0.0384
Loa Loa (eye worm) hypothetical protein 0.0064 0.0144 0.1196
Onchocerca volvulus 0.0012 0.0008 0.0032
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0066 0.0151 0.0359
Trypanosoma brucei oxidoreductase-like protein 0.0012 0.0008 0.0044
Brugia malayi nuclear hormone receptor 0.0038 0.0076 0.0623
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0083 0.0194 0.4453
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0012 0.0008 0.0005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0076 0.0623
Schistosoma mansoni peptidase Clp (S14 family) 0.0083 0.0194 0.0463
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0166 0.1367
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0038 0.0076 0.0629
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0174 0.0434 0.359
Mycobacterium ulcerans beta-lactamase 0.0072 0.0166 0.0163
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0196
Echinococcus granulosus tumor protein p63 0.0361 0.0924 0.4835
Loa Loa (eye worm) thioredoxin reductase 0.0075 0.0175 0.1446
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0018 0.0024 0.0127
Echinococcus granulosus single minded 2 0.0084 0.0198 0.1037
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0055 0.0052
Onchocerca volvulus 0.0072 0.0166 0.0986
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0038 0.0076 0.0623
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0008 0.0005
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0469 0.1208 0.2919
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.003 0.0027
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0012 0.0008 0.0122
Entamoeba histolytica hypothetical protein 0.0038 0.0078 0.0182
Brugia malayi topoisomerase 0.001 0.0003 0.0016
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.003 0.0055 0.0052
Trypanosoma brucei polo-like protein kinase 0.0109 0.0262 0.2153
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0038 0.0076 0.0118
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0262 0.0259
Giardia lamblia NADH oxidase lateral transfer candidate 0.0026 0.0046 0.1653
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0046 0.0356
Echinococcus multilocularis microtubule associated protein 2 0.0736 0.191 0.2964
Echinococcus multilocularis peptidase Clp (S14 family) 0.0054 0.0119 0.0185
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0038 0.0076 0.0177
Schistosoma mansoni carbonic anhydrase 0.1582 0.413 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0166 0.0163
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0023 0.002
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0166 0.0198
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0172 0.0428 0.0527
Echinococcus granulosus peptidase Clp S14 family 0.0054 0.0119 0.0624
Mycobacterium ulcerans integral membrane transporter 0.0102 0.0245 0.0242
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.003 0.0631
Loa Loa (eye worm) Smad1 0.0016 0.002 0.0164
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0083 0.0194 0.4435
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0023 0.0476
Brugia malayi Thioredoxin reductase 0.0075 0.0175 0.1441
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0076 0.0177
Loa Loa (eye worm) DR-78 0.0018 0.0024 0.0196
Loa Loa (eye worm) hypothetical protein 0.0123 0.0299 0.2478
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0039 0.0075
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0262 0.0259
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0027 0.0047 0.1034
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.0343 0.1793
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0102 0.0245 0.0242
Schistosoma mansoni cpg binding protein 0.003 0.0055 0.0128
Loa Loa (eye worm) hypothetical protein 0.0138 0.0338 0.2803
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0003 0.0000051411
Onchocerca volvulus 0.0018 0.0024 0.0127
Brugia malayi beta-lactamase 0.0072 0.0166 0.1367
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0012 0.0008 0.0044
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0093 0.2092
Plasmodium falciparum thioredoxin reductase 0.0075 0.0175 0.3986
Schistosoma mansoni RAR-like nuclear receptor 0.0038 0.0076 0.0177
Leishmania major hypothetical protein, conserved 0.0072 0.0166 0.0383
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0243
Brugia malayi serine/threonine-protein kinase plk-2 0.0109 0.0262 0.2166
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0076 0.0397
Echinococcus multilocularis geminin 0.0513 0.1323 0.2052
Mycobacterium tuberculosis Conserved protein 0.0072 0.0166 0.0198
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0191
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.003 0.0225
Toxoplasma gondii hypothetical protein 0.0028 0.0052 0.114
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0052 0.2569
Loa Loa (eye worm) hypothetical protein 0.0038 0.0076 0.0629
Loa Loa (eye worm) hypothetical protein 0.0038 0.0076 0.0629
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0196
Brugia malayi Steroid receptor seven-up type 2 0.0038 0.0076 0.0623
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0012 0.0008 0.0013
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0087 0.0455
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.0343 0.0531
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0055 0.0052
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.003 0.0055 0.0052
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.017 0.0423 0.0521
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0087 0.0455
Loa Loa (eye worm) transcription factor SMAD2 0.0239 0.0605 0.5006
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0018 0.0024 0.019
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0046 0.0356
Trypanosoma cruzi polo-like protein kinase, putative 0.0109 0.0262 0.2153
Schistosoma mansoni smad 0.0016 0.002 0.0042
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0018 0.0024 0.0124
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0191
Loa Loa (eye worm) hypothetical protein 0.0174 0.0434 0.3594
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0038 0.0076 0.0397
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.003 0.0156
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0019 0.0027 0.0221
Schistosoma mansoni coup transcription factor 0.0038 0.0076 0.0177
Entamoeba histolytica hypothetical protein 0.0038 0.0078 0.0182
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.003 0.0056 0.044
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0233 0.1923
Echinococcus granulosus ribonuclease H1 0.0027 0.0047 0.0247
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0166 0.1353
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0008 0.0005
Trypanosoma brucei RNA helicase, putative 0.01 0.024 0.1966
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.0359 0.1878
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0166 0.0163
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0191 0.0478 0.1151
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0083 0.0194 0.0463
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.3047 0.7974 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2464 0.6445 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0076 0.0629
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0008 0.0005
Onchocerca volvulus 0.0012 0.0008 0.0032
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.002 0.0029 0.0243
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.0052 0.0119
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0083 0.0194 0.0191
Trypanosoma brucei pteridine reductase 1 0.0012 0.0008 0.0044
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0026 0.0046 0.0994
Schistosoma mansoni hypothetical protein 0.0064 0.0144 0.0343
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0026 0.0046 0.0091
Schistosoma mansoni hypothetical protein 0.0064 0.0144 0.0343
Brugia malayi hypoxia-induced factor 1 0.0151 0.0374 0.3095
Schistosoma mansoni hypothetical protein 0.0064 0.0144 0.0343
Loa Loa (eye worm) MH2 domain-containing protein 0.0239 0.0605 0.5006
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0022
Loa Loa (eye worm) hypothetical protein 0.0083 0.0194 0.1606
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0102 0.0245 0.0242
Loa Loa (eye worm) hypothetical protein 0.0042 0.0087 0.0719
Brugia malayi nuclear hormone receptor family member nhr-6 0.0018 0.0024 0.019
Mycobacterium leprae Probable lipase LipE 0.0072 0.0166 0.0395
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0196
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0118 0.0116
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0811 0.2104 0.2632
Toxoplasma gondii thioredoxin reductase 0.0075 0.0175 0.3986
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0039 0.0087
Loa Loa (eye worm) hypothetical protein 0.0097 0.0233 0.1928
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0262 0.0259
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0109 0.0262 0.1372
Echinococcus multilocularis transfer RNA-Lys 0.0084 0.0198 0.0307
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0083 0.0194 0.4435
Loa Loa (eye worm) hypothetical protein 0.0038 0.0076 0.0629
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.003 0.0056 0.0294
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0066 0.0151 0.0148
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0083 0.0194
Giardia lamblia Ribonuclease H 0.0027 0.0047 0.1712
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0093 0.009
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.002 0.0031
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0459 0.1182 0.1474
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0066 0.0151 0.3438
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0012 0.0008 0.0044
Toxoplasma gondii hypothetical protein 0.0174 0.0434 1
Schistosoma mansoni hypothetical protein 0.004 0.0083 0.0194
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0173 0.0432 0.9961
Loa Loa (eye worm) hypothetical protein 0.0152 0.0377 0.3121
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0008 0.0005
Echinococcus granulosus ecdysone induced protein 78C 0.0038 0.0076 0.0397
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0173 0.0432 0.0533
Onchocerca volvulus Ribonuclease H1 homolog 0.0027 0.0047 0.0269
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.003 0.0628
Schistosoma mansoni dihydropteridine reductase 0.0012 0.0008 0.0013
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0038 0.0076 0.0397
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0087 0.0719
Toxoplasma gondii exonuclease III APE 0.002 0.003 0.0629
Schistosoma mansoni phosphoglucomutase 0.0027 0.0047 0.0108
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0166 0.1353
Loa Loa (eye worm) hypothetical protein 0.0174 0.0434 0.3594
Trichomonas vaginalis adenylate cyclase, putative 0.003 0.0055 0.0052
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.002 0.0164
Loa Loa (eye worm) hypothetical protein 0.0023 0.0039 0.032
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0008 0.0005
Onchocerca volvulus Putative sulfate transporter 0.064 0.1656 1
Echinococcus granulosus carbonic anhydrase 0.0174 0.0434 0.2272
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.003 0.0055 0.0052
Loa Loa (eye worm) hypothetical protein 0.0072 0.0166 0.1372
Echinococcus multilocularis nibrin 0.001 0.0003 0.0004
Schistosoma mansoni smad1 5 8 and 0.0016 0.002 0.0042
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.002 0.0029 0.0153
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.0262 0.0628
Echinococcus multilocularis protein dispatched 1 0.0048 0.0102 0.0159
Leishmania major protein kinase, putative 0.003 0.0056 0.0116
Schistosoma mansoni aryl hydrocarbon receptor 0.0237 0.0599 0.1446
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0039 0.0087
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0029 0.0237
Brugia malayi nuclear hormone receptor 0.0018 0.0024 0.019
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.003 0.0225
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0039 0.0036
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0078 0.0408
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.003 0.0056 0.044
Brugia malayi RNase H family protein 0.0027 0.0047 0.0384
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0144 0.0224
Loa Loa (eye worm) hypothetical protein 0.0252 0.0639 0.5295
Schistosoma mansoni kinase 0.0055 0.0122 0.0289
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0026 0.0046 0.0356
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.003 0.1045
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0233 0.0361
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0109 0.0262 0.217
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.002 0.0164
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0024 0.0051
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0066 0.0151 0.125
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0127 0.2881
Loa Loa (eye worm) acetyltransferase 0.015 0.037 0.3061
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0012 0.0008 0.0122
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0012 0.0008 0.0005
Brugia malayi RNase H family protein 0.0027 0.0047 0.0384
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0051 0.0423
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0102 0.0245 0.5608
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0026 0.0046 0.0994
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0038 0.0076 0.0629
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0102 0.0245 0.2008
Echinococcus multilocularis Smad4 0.0016 0.002 0.0031
Echinococcus granulosus aryl hydrocarbon receptor 0.0153 0.0378 0.1981
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0066 0.0151 0.3451
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0066 0.0151 0.1231
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0087 0.0084
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0093 0.2084
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0134 0.0318
Loa Loa (eye worm) hypothetical protein 0.0018 0.0024 0.0196
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.002 0.0104
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0039 0.0036
Trichomonas vaginalis guanylate cyclase, putative 0.003 0.0055 0.0052
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0262 0.0259
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0102 0.0245 0.2008
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0093 0.2084
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0008 0.0005
Echinococcus granulosus Nuclear hormone receptor HR96 0.0018 0.0024 0.0124
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0038 0.0076 0.0629
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0076 0.0118
Brugia malayi conserved hypotetical protein 0.0018 0.0024 0.019
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0003 0.0016
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0026 0.0046 0.0998
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0039 0.0075
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0054 0.0119 0.014
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0144 0.119
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0012 0.0008 0.0005
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.003 0.0055 0.0113
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0166 0.0198
Mycobacterium ulcerans hypothetical protein 0.0023 0.0039 0.0036
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0166 0.0868
Mycobacterium ulcerans oxidoreductase 0.0012 0.0008 0.0005
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0083 0.0194 0.0301
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0173 0.0432 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0018 0.0024 0.0037
Mycobacterium tuberculosis Probable dehydrogenase 0.0172 0.0428 0.0527
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0109 0.0262 0.0407
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0172 0.0428 0.0527
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.003 0.0055 0.0432
Onchocerca volvulus 0.0152 0.0377 0.2263

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 0.16 uM Inhibitory activity against human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) ChEMBL. 12086483
Activity (binding) = 0.16 uM Inhibitory activity against human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) ChEMBL. 12086483
CC50 (functional) > 200 uM Cytotoxicity against MT-4 cells. ChEMBL. 11472208
CC50 (functional) > 200 uM Cytotoxicity against MT-4 cells. ChEMBL. 11472208
EC50 (functional) = 0.16 uM Effective concentration against HIV-1 induced cytopathogenicity in MT-4 cells ChEMBL. 11472208
Selectivity index (functional) > 1250 CC50/EC50 ratio of the compound ChEMBL. 11472208

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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