Detailed information for compound 1374058

Basic information

Technical information
  • TDR Targets ID: 1374058
  • Name: N-(2,3-dihydro-1,4-benzodioxin-7-yl)-2-([1,2, 4]triazolo[4,5-a]pyridin-3-ylsulfanyl)acetami de
  • MW: 342.372 | Formula: C16H14N4O3S
  • H donors: 1 H acceptors: 3 LogP: 2.64 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc2c(c1)OCCO2)CSc1nnc2n1cccc2
  • InChi: 1S/C16H14N4O3S/c21-15(10-24-16-19-18-14-3-1-2-6-20(14)16)17-11-4-5-12-13(9-11)23-8-7-22-12/h1-6,9H,7-8,10H2,(H,17,21)
  • InChiKey: SPSHJWLFDYHEHQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,3-dihydro-1,4-benzodioxin-7-yl)-2-([1,2,4]triazolo[4,5-a]pyridin-3-ylthio)acetamide
  • N-(2,3-dihydro-1,4-benzodioxin-7-yl)-2-([1,2,4]triazolo[4,5-a]pyridin-3-ylsulfanyl)ethanamide
  • SMR000354527
  • ZINC00125707
  • T0501-3061
  • MLS001018252

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.27 0.9732
Echinococcus multilocularis GPCR, family 2 0.0031 0.0129 0.0129
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0057 0.0405 0.146
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0184 0.1724 0.1724
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0082 0.0664 0.1539
Schistosoma mansoni cpg binding protein 0.0033 0.0148 0.0296
Trypanosoma brucei polo-like protein kinase 0.0184 0.1724 0.6215
Schistosoma mansoni hypothetical protein 0.0066 0.05 0.1004
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0051 0.0118
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0691 0.15
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0285 0.2774 0.5574
Onchocerca volvulus 0.013 0.1159 0.2652
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0083 0.0668 0.1547
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0051 0.0118
Trichomonas vaginalis CAMK family protein kinase 0.0184 0.1724 0.6215
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0785 0.1577
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0261 0.0605
Loa Loa (eye worm) hypothetical protein 0.0028 0.0099 0.0234
Brugia malayi Hemopexin family protein 0.0184 0.1723 0.5607
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0019 0.0008 0.0031
Entamoeba histolytica hypothetical protein 0.0043 0.0261 0.0941
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0083 0.0668 0.1547
Mycobacterium ulcerans hypothetical protein 0.0027 0.0092 0.0212
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0051 0.0118
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0285 0.2774 0.5574
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0263 0.0949
Mycobacterium leprae Conserved membrane protein 0.0027 0.0092 0.0095
Trichomonas vaginalis aldo-keto reductase, putative 0.0285 0.2774 1
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0195 0.0462
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0057 0.0405 0.146
Schistosoma mansoni inositol 145-trisphosphate receptor 0.005 0.0326 0.0655
Trichomonas vaginalis CAMK family protein kinase 0.0184 0.1724 0.6215
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0129 0.0129
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0051 0.0184
Schistosoma mansoni hypothetical protein 0.0031 0.0129 0.0258
Loa Loa (eye worm) hypothetical protein 0.0043 0.0261 0.0618
Echinococcus granulosus transcription factor btf3 0.0034 0.0162 0.0326
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0757 0.2729
Leishmania major hypothetical protein, conserved 0.0049 0.032 0.1153
Onchocerca volvulus 0.0231 0.2215 0.5181
Loa Loa (eye worm) hypothetical protein 0.0051 0.034 0.0804
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0285 0.2774 0.2774
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0162 0.0585
Schistosoma mansoni alpha-glucosidase 0.0169 0.1571 0.3157
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0067 0.0506 0.1825
Toxoplasma gondii hypothetical protein 0.0082 0.0664 0.1539
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0263 0.0949
Loa Loa (eye worm) hepatopoietin HPO2 0.0067 0.0506 0.1197
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0022 0.0041 0.0149
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0083 0.0668 0.1342
Echinococcus multilocularis aldo keto reductase 0.0285 0.2774 0.2774
Loa Loa (eye worm) matrixin family protein 0.0288 0.2803 0.663
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0254 0.0915
Entamoeba histolytica hypothetical protein 0.0034 0.0162 0.0585
Loa Loa (eye worm) hypothetical protein 0.0119 0.1046 0.2475
Echinococcus granulosus peregrin 0.0038 0.0204 0.0409
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.0789 0.2845
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0122 0.0245
Trichomonas vaginalis mannosyltransferase 1, putative 0.0027 0.0092 0.033
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1016 0.2403
Entamoeba histolytica hypothetical protein 0.0043 0.0261 0.0941
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0051 0.0118
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0033 0.0153 0.0308
Echinococcus multilocularis voltage gated potassium channel subunit 0.0083 0.0668 0.0668
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0162 0.0376
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0162 0.0585
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.0104 0.0893 0.3219
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0785 0.0785
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0121
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0263 0.0949
Onchocerca volvulus Matrilysin homolog 0.0288 0.2803 0.6589
Loa Loa (eye worm) hypothetical protein 0.0031 0.0129 0.0304
Plasmodium falciparum glutathione reductase 0.0037 0.0195 0.0453
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0261 0.0942
Onchocerca volvulus 0.0043 0.0261 0.0503
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0261 0.0524
Loa Loa (eye worm) hypothetical protein 0.0088 0.0727 0.172
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0129 0.0419
Loa Loa (eye worm) hypothetical protein 0.0037 0.0198 0.0469
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0285 0.2774 0.2774
Brugia malayi MH2 domain containing protein 0.0116 0.1016 0.3306
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0092 0.033
Onchocerca volvulus 0.0043 0.0261 0.0503
Mycobacterium ulcerans malate dehydrogenase 0.0043 0.0254 0.0588
Onchocerca volvulus Papilin homolog 0.0028 0.0099 0.0114
Trichomonas vaginalis aldo-keto reductase, putative 0.0285 0.2774 1
Plasmodium falciparum aldo-keto reductase, putative 0.0083 0.0668 0.1547
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0092 0.033
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0261 0.0605
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0043 0.0254 0.0915
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0433 0.4316 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0263 0.0949
Brugia malayi ADAMTS-like protease 0.0027 0.009 0.0294
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1046 0.1046
Loa Loa (eye worm) MIR domain-containing protein 0.005 0.0326 0.0771
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0022 0.0041 0.0149
Entamoeba histolytica peptidase, C54 family 0.0022 0.0041 0.0149
Plasmodium falciparum phd finger protein, putative 0.0029 0.0107 0.0247
Onchocerca volvulus 0.0285 0.2774 0.652
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0129 0.0419
Entamoeba histolytica MIR domain protein 0.005 0.0326 0.1174
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0019 0.0008 0.002
Brugia malayi ADAM-TS Spacer 1 family protein 0.0088 0.0727 0.2366
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.0789 0.2845
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0043 0.0254 0.0915
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0107 0.0107
Giardia lamblia Kinase, PLK 0.0184 0.1724 0.6215
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0074 0.0265
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0148 0.0349
Brugia malayi Matrixin family protein 0.013 0.1159 0.3771
Schistosoma mansoni aldo-keto reductase 0.0285 0.2774 0.5574
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0261 0.0942
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.0789 0.173
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0285 0.2774 0.2774
Trichomonas vaginalis aldo/keto reductase, putative 0.0285 0.2774 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.1856 0.6041
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0022 0.0041 0.0149
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0285 0.2774 1
Schistosoma mansoni cpg binding protein 0.0033 0.0148 0.0296
Schistosoma mansoni hypothetical protein 0.0049 0.0321 0.0644
Echinococcus granulosus DNA methyltransferase 2, putative 0.0019 0.0008 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0184 0.1724 0.3465
Mycobacterium tuberculosis Conserved protein 0.0083 0.0668 0.2407
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.032 0.0741
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0057 0.0405 0.0814
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0285 0.2774 0.9028
Trichomonas vaginalis aldo-keto reductase, putative 0.0285 0.2774 1
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.034 0.1225
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0285 0.2774 1
Echinococcus multilocularis Peptidase C54 0.0057 0.0405 0.0405
Toxoplasma gondii DNA methyltransferase 2, putative 0.0019 0.0008 0.002
Onchocerca volvulus 0.0285 0.2774 0.652
Schistosoma mansoni hypothetical protein 0.0497 0.4977 1
Mycobacterium tuberculosis Probable reductase 0.0085 0.0691 0.249
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0169 0.0401
Trichomonas vaginalis mannosyltransferase, putative 0.0027 0.0092 0.033
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0129 0.0129
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0162 0.0585
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0092 0.033
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0285 0.2774 0.2774
Schistosoma mansoni hypothetical protein 0.0043 0.0261 0.0524
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0107 0.0253
Giardia lamblia Malate dehydrogenase 0.0043 0.0254 0.0915
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0038 0.0038
Onchocerca volvulus 0.0285 0.2774 0.652
Mycobacterium leprae Probable lipase LipE 0.0043 0.0261 0.0493
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0668 0.2407
Brugia malayi hypothetical protein 0.0049 0.032 0.1041
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0691 0.249
Onchocerca volvulus 0.0285 0.2774 0.652
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0162 0.0585
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0261 0.0942
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0169 0.0341
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0263 0.0856
Entamoeba histolytica hypothetical protein 0.0043 0.0261 0.0941
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0195 0.0453
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0169 0.0169
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0129 0.0304
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0038 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.1224 0.4413
Brugia malayi CXXC zinc finger family protein 0.0033 0.0148 0.048
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.0433 0.4316 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0254 0.0915
Schistosoma mansoni alpha glucosidase 0.0044 0.0263 0.0529
Loa Loa (eye worm) oxidoreductase 0.0285 0.2774 0.6562
Plasmodium falciparum flap endonuclease 1 0.0025 0.0074 0.017
Brugia malayi Disco-interacting protein 2 homolog 0.0037 0.0198 0.0645
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.1224 0.4413
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.034 0.0804
Loa Loa (eye worm) hypothetical protein 0.0043 0.0261 0.0618
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0099 0.02
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0201 0.0201
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0433 0.4316 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0051 0.0166
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.0043 0.0254 0.0476
Schistosoma mansoni hypothetical protein 0.0184 0.1723 0.3462
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0263 0.0949
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0074 0.0265
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0083 0.0668 0.1547
Onchocerca volvulus 0.0043 0.0261 0.0503
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0043 0.0254 0.0254
Brugia malayi MIR domain containing protein 0.005 0.0326 0.106
Onchocerca volvulus 0.003 0.0122 0.0169
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0254 0.0915
Trichomonas vaginalis mannosyltransferase 1, putative 0.0136 0.1224 0.4413
Echinococcus multilocularis expressed conserved protein 0.0112 0.0971 0.0971
Loa Loa (eye worm) hypothetical protein 0.0062 0.0459 0.1086
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0261 0.0942
Leishmania major cytosolic malate dehydrogenase 0.0043 0.0254 0.0915
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.032 0.0741
Loa Loa (eye worm) hypothetical protein 0.0043 0.0261 0.0618
Trichomonas vaginalis aldo/keto reductase, putative 0.0285 0.2774 1
Schistosoma mansoni hypothetical protein 0.0022 0.0038 0.0076
Trichomonas vaginalis mannosyltransferase 1, putative 0.0027 0.0092 0.033
Schistosoma mansoni hypothetical protein 0.0049 0.0321 0.0644
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0067 0.0506 0.1173
Onchocerca volvulus Matrix metalloproteinase homolog 0.0288 0.2803 0.6589
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0051 0.0118
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0122 0.0245
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0074 0.017
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.1924 0.4551
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0691 0.249
Entamoeba histolytica peptidase, C54 family 0.0022 0.0041 0.0149
Brugia malayi glutathione reductase 0.0037 0.0195 0.0636
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0691 0.249
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1577 0.3169
Plasmodium falciparum cysteine protease ATG4, putative 0.0022 0.0041 0.0096
Brugia malayi Peptidase family C54 containing protein 0.0057 0.0405 0.1318
Leishmania major hypothetical protein, conserved 0.0067 0.0506 0.1825
Trichomonas vaginalis aldo-keto reductase, putative 0.0285 0.2774 1
Brugia malayi Thioredoxin reductase 0.0037 0.0195 0.0636
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0285 0.2774 0.2774
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1577 0.1577
Loa Loa (eye worm) glutathione reductase 0.0037 0.0195 0.0462
Echinococcus multilocularis adam 0.0025 0.0072 0.0072
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0285 0.2774 0.2774
Brugia malayi Augmenter of liver regeneration 0.0067 0.0506 0.1648
Brugia malayi hypothetical protein 0.0032 0.0139 0.0452
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.1224 0.4413
Trichomonas vaginalis aldo-keto reductase, putative 0.0083 0.0668 0.2407
Loa Loa (eye worm) oxidoreductase 0.0285 0.2774 0.6562
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0261 0.0261
Schistosoma mansoni autophagin-1 (C54 family) 0.0057 0.0405 0.0814
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0057 0.0405 0.146
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0158 0.1453 0.5237
Schistosoma mansoni flap endonuclease-1 0.0023 0.0048 0.0097
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0037 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0049 0.032 0.0757
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0285 0.2774 0.9028
Plasmodium falciparum thioredoxin reductase 0.0037 0.0195 0.0453
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0158 0.1453 0.4728
Loa Loa (eye worm) hypothetical protein 0.0029 0.0107 0.0253
Echinococcus granulosus cysteine protease atg4b 0.0057 0.0405 0.0814
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.1224 0.4413
Echinococcus multilocularis aldo keto reductase 0.0285 0.2774 0.2774
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0037 0.0192 0.0387
Mycobacterium ulcerans lipase LipD 0.0043 0.0261 0.0605
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0043 0.0254 0.0915
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0254 0.0915
Schistosoma mansoni transcription factor btf3 0.0034 0.0162 0.0326
Trichomonas vaginalis mannosyltransferase 1, putative 0.005 0.0326 0.1174
Entamoeba histolytica aldose reductase, putative 0.0285 0.2774 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0326 0.0771
Schistosoma mansoni potassium channel beta 0.0083 0.0668 0.1342
Echinococcus multilocularis stromal cell derived factor 2 0.005 0.0326 0.0326
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0067 0.0506 0.0506
Loa Loa (eye worm) hypothetical protein 0.0025 0.0072 0.017
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0169 0.0341
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0263 0.0949
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0285 0.2774 0.5574
Echinococcus multilocularis aldo keto reductase 0.0285 0.2774 0.2774
Trichomonas vaginalis malate dehydrogenase, putative 0.0034 0.0158 0.0569
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0057 0.0405 0.146
Loa Loa (eye worm) oxidoreductase 0.0285 0.2774 0.6562
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0285 0.2774 0.5574
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0261 0.0525
Trichomonas vaginalis CAMK family protein kinase 0.0184 0.1724 0.6215
Trichomonas vaginalis CAMK family protein kinase 0.0184 0.1724 0.6215
Loa Loa (eye worm) oxidoreductase 0.0285 0.2774 0.6562
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0074 0.0265
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0285 0.2774 0.5574
Trichomonas vaginalis aldo-keto reductase, putative 0.0083 0.0668 0.2407
Onchocerca volvulus 0.0184 0.1723 0.4003
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0057 0.0405 0.0814
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0261 0.0942
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0263 0.0949
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0067 0.0506 0.1825
Onchocerca volvulus Phospholipase A2 homolog 0.0089 0.0739 0.1647
Brugia malayi Matrixin family protein 0.013 0.1159 0.3771
Schistosoma mansoni malate dehydrogenase 0.0043 0.0254 0.051
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.0789 0.2845
Plasmodium vivax glutathione reductase, putative 0.0037 0.0195 0.0453
Loa Loa (eye worm) hypothetical protein 0.0043 0.0261 0.0618
Onchocerca volvulus 0.0037 0.0198 0.0352
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0067 0.0506 0.1825
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0254 0.0915
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0051 0.0118
Loa Loa (eye worm) hypothetical protein 0.0043 0.0261 0.0618
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0162 0.0376
Schistosoma mansoni hypothetical protein 0.0031 0.0129 0.0258
Mycobacterium tuberculosis Conserved protein 0.0043 0.0261 0.0942
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0074 0.0265
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.005 0.0326 0.106
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0263 0.0949
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0691 0.249
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0261 0.0261
Toxoplasma gondii Erv1 / Alr family protein 0.0067 0.0506 0.1173
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0051 0.0166
Schistosoma mansoni hypothetical protein 0.0049 0.0321 0.0644
Leishmania major prostaglandin f synthase, putative 0.0285 0.2774 1
Schistosoma mansoni malate dehydrogenase 0.0043 0.0254 0.051
Echinococcus multilocularis transcription factor btf3 0.0034 0.0162 0.0162
Loa Loa (eye worm) matrix metalloproteinase 0.013 0.1159 0.2741
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.013 0.1159 0.2328
Schistosoma mansoni kinase 0.0094 0.0782 0.1572
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0051 0.0184
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0263 0.061
Echinococcus granulosus adam 0.0025 0.0072 0.0145
Entamoeba histolytica hypothetical protein 0.0043 0.0261 0.0941
Echinococcus granulosus Peptidase C54 0.0057 0.0405 0.0814
Trichomonas vaginalis CAMK family protein kinase 0.0184 0.1724 0.6215
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0263 0.0949
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1016 0.2403
Brugia malayi Flap endonuclease-1 0.0025 0.0074 0.0239
Trichomonas vaginalis aldo-keto reductase, putative 0.0285 0.2774 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.0739 0.1748
Trypanosoma cruzi polo-like protein kinase, putative 0.0184 0.1724 0.6215
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0043 0.0254 0.0915
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0263 0.0263
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0254 0.0915
Entamoeba histolytica peptidase, C54 family 0.0022 0.0041 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.1224 0.4413
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0092 0.033
Loa Loa (eye worm) hypothetical protein 0.005 0.0326 0.0771
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0038 0.0208 0.0418
Brugia malayi Matrixin family protein 0.013 0.1159 0.3771
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0051 0.0184
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0285 0.2774 0.5574
Echinococcus granulosus cytosolic malate dehydrogenase 0.0043 0.0254 0.051
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.032 0.1153
Toxoplasma gondii ABC1 family protein 0.0043 0.0261 0.0605
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0043 0.0254 0.0915
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0043 0.0254 0.0826
Mycobacterium ulcerans hypothetical protein 0.0043 0.0261 0.0605
Mycobacterium tuberculosis Probable oxidoreductase 0.0285 0.2774 1
Echinococcus multilocularis protein patched 0.0051 0.034 0.034
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.1856 0.1856
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0067 0.0506 0.1825
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0121
Leishmania major basic transcription factor 3a, putative 0.0034 0.0162 0.0585
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0285 0.2774 0.5574
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0254 0.0915
Mycobacterium ulcerans hydrolase 0.0158 0.1453 0.3366
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0261 0.0942
Toxoplasma gondii aldo-keto reductase 0.0083 0.0668 0.1547
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.032 0.0741
Echinococcus granulosus cytosolic malate dehydrogenase 0.0043 0.0254 0.051
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0074 0.017
Schistosoma mansoni hypothetical protein 0.0497 0.4977 1
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0162 0.0585
Giardia lamblia Aldose reductase 0.0285 0.2774 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.082 0.1939
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0261 0.0525
Trypanosoma brucei aldo-keto reductase, putative 0.0285 0.2774 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0254 0.0915
Trichomonas vaginalis mannosyltransferase 1, putative 0.0027 0.0092 0.033
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0019 0.0008 0.0008
Chlamydia trachomatis 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0433 0.4316 1
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0083 0.0668 0.2407
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0057 0.0405 0.146
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0092 0.033
Trichomonas vaginalis aldo-keto reductase, putative 0.0285 0.2774 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.032 0.1153
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0129 0.0258
Toxoplasma gondii thioredoxin reductase 0.0037 0.0195 0.0453
Onchocerca volvulus Serine\/threonine kinase homolog 0.0184 0.1724 0.4006
Brugia malayi hypothetical protein 0.0025 0.0072 0.0234
Entamoeba histolytica alcohol dehydrogenase, putative 0.0083 0.0668 0.2407
Loa Loa (eye worm) hypothetical protein 0.0057 0.0405 0.0958
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0584 0.1174
Onchocerca volvulus 0.0033 0.0148 0.0231
Brugia malayi jmjC domain containing protein 0.0094 0.0785 0.2554
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0285 0.2774 0.2774
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0285 0.2774 1
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.032 0.0741
Trichomonas vaginalis mannosyltransferase 1, putative 0.0136 0.1224 0.4413
Trichomonas vaginalis aldo-keto reductase, putative 0.0285 0.2774 1
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0067 0.0506 0.1017
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0083 0.0668 0.1579
Loa Loa (eye worm) hypothetical protein 0.013 0.1159 0.2741
Toxoplasma gondii Erv1 / Alr family protein 0.0067 0.0506 0.1173
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0043 0.0254 0.0915
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0169 0.0341
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.1856 0.4391
Onchocerca volvulus 0.0114 0.0993 0.2255
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0107 0.0215
Brugia malayi serine/threonine-protein kinase plk-2 0.0184 0.1724 0.5611
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0074 0.0265
Onchocerca volvulus 0.005 0.0326 0.0658
Trypanosoma cruzi aldo/keto reductase, putative 0.0285 0.2774 1
Echinococcus granulosus voltage gated potassium channel subunit 0.0083 0.0668 0.1342
Onchocerca volvulus 0.0083 0.0668 0.1476
Echinococcus granulosus ryanodine receptor 44f 0.005 0.0326 0.0655
Echinococcus multilocularis cpg binding protein 0.0033 0.0148 0.0148
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.082 0.1939
Brugia malayi Pre-SET motif family protein 0.0203 0.1924 0.6262
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0285 0.2774 0.6384
Trichomonas vaginalis CAMK family protein kinase 0.0184 0.1724 0.6215
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0261 0.0942
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0263 0.0529
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0195 0.0704
Echinococcus granulosus hypothetical protein 0.0285 0.2774 0.5574
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.0433 0.4316 1
Brugia malayi Matrixin family protein 0.0314 0.3073 1
Echinococcus multilocularis aldo keto reductase 0.0285 0.2774 0.2774
Giardia lamblia Aldose reductase 0.0285 0.2774 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0051 0.0184
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1065 0.214
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0261 0.0605
Echinococcus granulosus expressed conserved protein 0.0112 0.0971 0.1951
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0261 0.0493
Brugia malayi NADH-dependent xylose reductase 0.0083 0.0668 0.2173
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0433 0.4316 1
Plasmodium falciparum aldehyde reductase, putative 0.0083 0.0668 0.1547
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0261 0.0942
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0107 0.0215
Echinococcus granulosus stromal cell derived factor 2 0.005 0.0326 0.0655
Echinococcus multilocularis cysteine protease atg4b 0.0057 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0066 0.05 0.1182
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0261 0.0942
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0285 0.2774 0.5574
Echinococcus granulosus geminin 0.0497 0.4977 1
Leishmania major modification methylase-like protein 0.0019 0.0008 0.0031
Onchocerca volvulus 0.0285 0.2774 0.652
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0261 0.0942
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0162 0.0585
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0092 0.033
Trypanosoma brucei prostaglandin f synthase 0.0285 0.2774 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0184 0.1724 0.6215
Brugia malayi beta-lactamase 0.0043 0.0261 0.085
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0254 0.0915
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0263 0.0949
Entamoeba histolytica peptidase, C54 family 0.0022 0.0041 0.0149
Loa Loa (eye worm) hypothetical protein 0.005 0.0326 0.0771
Entamoeba histolytica peptidase, C54 family 0.0057 0.0405 0.146
Brugia malayi beta-NAC-like protein 0.0034 0.0162 0.0528
Mycobacterium leprae Conserved hypothetical protein 0.0202 0.1915 0.4371
Loa Loa (eye worm) matrixin family protein 0.0314 0.3073 0.7268
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0285 0.2774 0.2774
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.05 0.1627
Trypanosoma brucei trypanothione reductase 0.0037 0.0195 0.0704
Loa Loa (eye worm) hypothetical protein 0.0425 0.4228 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0122 0.0122
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0074 0.0074
Leishmania major hypothetical protein, conserved 0.0043 0.0261 0.0942
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0261 0.0942
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.034 0.0683
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0057 0.0405 0.146
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0254 0.0915
Brugia malayi beta-lactamase family protein 0.0043 0.0261 0.085
Trypanosoma brucei glucosidase, putative 0.0044 0.0263 0.0949
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0107 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0092 0.033
Brugia malayi angiogenesis inhibito 0.0027 0.009 0.0294
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0122 0.0122
Trichomonas vaginalis mannosyltransferase 1, putative 0.0027 0.0092 0.033
Giardia lamblia PHD finger protein 15 0.0029 0.0107 0.0385
Trypanosoma brucei aldo/keto reductase, putative 0.0083 0.0668 0.2407
Loa Loa (eye worm) hypothetical protein 0.003 0.0122 0.0288
Echinococcus granulosus Protein patched homolog 1 0.0051 0.034 0.0683
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0691 0.249
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0051 0.0184
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0261 0.0942
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0043 0.0254 0.0915
Trichomonas vaginalis aldo/keto reductase, putative 0.0285 0.2774 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0043 0.0254 0.0915
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0051 0.0166
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0051 0.0118
Brugia malayi Pre-SET motif family protein 0.003 0.0122 0.0396
Trichomonas vaginalis CAMK family protein kinase 0.0184 0.1724 0.6215
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0285 0.2774 1
Leishmania major aldo-keto reductase-like protein 0.0285 0.2774 1
Echinococcus multilocularis aldehyde reductase 0.0202 0.1915 0.1915
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0285 0.2774 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0261 0.0525
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0263 0.0622
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0092 0.033
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0285 0.2774 0.9028
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0019 0.0008 0.0017
Mycobacterium ulcerans hypothetical protein 0.0083 0.0668 0.1547
Schistosoma mansoni SET domain protein 0.0033 0.0153 0.0308
Echinococcus granulosus cpg binding protein 0.0033 0.0148 0.0296
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0223 0.0223
Echinococcus granulosus aldo keto reductase 0.0285 0.2774 0.5574
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0033 0.0153 0.0153
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0261 0.0524
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0285 0.2774 0.5574
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0263 0.0949
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.1856 0.373
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0043 0.0254 0.0254
Mycobacterium ulcerans beta-lactamase 0.0043 0.0261 0.0605
Mycobacterium ulcerans hypothetical protein 0.0023 0.0051 0.0118
Entamoeba histolytica serine/threonine protein kinase, putative 0.0184 0.1724 0.6215
Echinococcus granulosus flap endonuclease 1 0.0025 0.0074 0.0148
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0472 0.4717 0.9478
Echinococcus multilocularis geminin 0.0497 0.4977 0.4977
Mycobacterium leprae Possible oxidoreductase 0.0083 0.0668 0.1446
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0037 0.0192 0.0387
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0162 0.0585
Brugia malayi beta-lactamase family protein 0.0043 0.0261 0.085
Toxoplasma gondii autophagy-related cysteine peptidase atg4, putative 0.0022 0.0041 0.0096
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0043 0.0254 0.0915
Brugia malayi Bromodomain containing protein 0.0029 0.0107 0.0347
Echinococcus multilocularis peregrin 0.0038 0.0204 0.0204
Schistosoma mansoni hypothetical protein 0.0049 0.0321 0.0644
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0051 0.0184
Entamoeba histolytica malate dehydrogenase, putative 0.0043 0.0254 0.0915
Schistosoma mansoni hypothetical protein 0.0031 0.0129 0.0258
Trichomonas vaginalis aldo-keto reductase, putative 0.0285 0.2774 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0261 0.085
Entamoeba histolytica aldose reductase, putative 0.0285 0.2774 1
Echinococcus multilocularis ryanodine receptor 44f 0.005 0.0326 0.0326
Leishmania major trypanothione reductase 0.0037 0.0195 0.0704
Trichomonas vaginalis aldo-keto reductase, putative 0.0285 0.2774 1
Echinococcus granulosus aldo keto reductase 0.0285 0.2774 0.5574
Schistosoma mansoni patched 1 0.0051 0.034 0.0683
Echinococcus granulosus aldehyde reductase 0.0202 0.1915 0.3848
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0051 0.0184
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1046 0.3404
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0285 0.2774 0.2774
Mycobacterium ulcerans oxidoreductase 0.0285 0.2774 0.6427
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0285 0.2774 0.9028
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0019 0.0008 0.0031
Brugia malayi CHE-14 protein 0.0051 0.034 0.1106
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.034 0.034
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.1224 0.4413
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0019 0.0008 0.002
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0107 0.0247
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0261 0.0618
Schistosoma mansoni hypothetical protein 0.0031 0.0129 0.0258
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0129 0.0258
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0122 0.0245
Entamoeba histolytica alcohol dehydrogenase, putative 0.0083 0.0668 0.2407
Brugia malayi PHD-finger family protein 0.0029 0.0107 0.0347
Onchocerca volvulus Phospholipase A2 homolog 0.0425 0.4228 1
Schistosoma mansoni cpg binding protein 0.0033 0.0148 0.0296
Brugia malayi Phospholipase A2 family protein 0.0089 0.0739 0.2405
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0263 0.0949
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0022 0.0041 0.0149
Loa Loa (eye worm) hypothetical protein 0.0158 0.1453 0.3437
Plasmodium vivax aldehyde reductase, putative 0.0083 0.0668 0.1547
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0261 0.0942
Brugia malayi jmjC domain containing protein 0.0035 0.0169 0.0551
Loa Loa (eye worm) hypothetical protein 0.0285 0.2774 0.6562
Trichomonas vaginalis aldo-keto reductase, putative 0.0083 0.0668 0.2407
Loa Loa (eye worm) hypothetical protein 0.013 0.1159 0.2741
Trichomonas vaginalis esterase, putative 0.0043 0.0261 0.0942
Echinococcus multilocularis protein dispatched 1 0.0058 0.0415 0.0415
Echinococcus granulosus aldo keto reductase 0.0285 0.2774 0.5574
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0074 0.0174
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0285 0.2774 0.2774
Mycobacterium tuberculosis Conserved protein 0.0043 0.0261 0.0942
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0162 0.0376
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0025 0.0072 0.0145
Echinococcus granulosus jumonji domain containing protein 0.004 0.0223 0.0449
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0184 0.1724 0.3465
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.0757 0.2729
Loa Loa (eye worm) beta-lactamase 0.0043 0.0261 0.0618
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0263 0.0949
Trichomonas vaginalis aldo-keto reductase, putative 0.0285 0.2774 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0285 0.2774 1
Trichomonas vaginalis mannosyltransferase 1, putative 0.0136 0.1224 0.4413
Toxoplasma gondii aldose reductase, putative 0.0285 0.2774 0.6427
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1046 0.3771
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0201 0.0403
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0184 0.1724 0.6215
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0067 0.0506 0.1173
Schistosoma mansoni stromal cell-derived factor 2 precursor-like protein 0.005 0.0326 0.0655
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0261 0.0942
Entamoeba histolytica aldose reductase, putative 0.0285 0.2774 1
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.0433 0.4316 1
Brugia malayi hypothetical protein 0.0043 0.0261 0.0849
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0057 0.0405 0.146
Loa Loa (eye worm) oxidoreductase 0.0285 0.2774 0.6562
Trypanosoma cruzi aldo-keto reductase 0.0285 0.2774 1
Schistosoma mansoni pol-related 0.0285 0.2774 0.5574
Schistosoma mansoni ryanodine receptor related 0.005 0.0326 0.0655
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0263 0.0949
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.1856 0.1856
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0184 0.1724 0.4079
Loa Loa (eye worm) hypothetical protein 0.0049 0.032 0.0756
Schistosoma mansoni hypothetical protein 0.0029 0.0107 0.0215
Trichomonas vaginalis set domain proteins, putative 0.0231 0.2215 0.7984
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0051 0.0184
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0057 0.0405 0.146
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0019 0.0008 0.002
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1046 0.2102
Schistosoma mansoni aldo-keto reductase 0.0285 0.2774 0.5574
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.082 0.2667
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0092 0.033
Brugia malayi Matrixin family protein 0.013 0.1159 0.3771
Brugia malayi cation channel family protein 0.005 0.0326 0.106
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.082 0.2667
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0083 0.0668 0.2407
Trypanosoma cruzi aldo/keto reductase, putative 0.0083 0.0668 0.2407
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0092 0.033
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0122 0.0245
Schistosoma mansoni alpha-glucosidase 0.0169 0.1571 0.3157
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0433 0.4316 1
Echinococcus granulosus GPCR family 2 0.0031 0.0129 0.0258
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0261 0.0942
Loa Loa (eye worm) hypothetical protein 0.0023 0.0051 0.0121
Echinococcus multilocularis disco interacting protein 2 0.0038 0.0208 0.0208
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0083 0.0668 0.2173
Loa Loa (eye worm) hypothetical protein 0.0043 0.0261 0.0618
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0162 0.0384
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0122 0.0282
Echinococcus granulosus disco interacting protein 2 0.0038 0.0208 0.0418
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0285 0.2774 0.2774
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0472 0.4717 0.4717
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0424 0.1003
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.032 0.1153
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0122 0.0245
Trichomonas vaginalis conserved hypothetical protein 0.0136 0.1224 0.4413
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0107 0.0247
Plasmodium vivax SET domain protein, putative 0.003 0.0122 0.0282
Mycobacterium tuberculosis Conserved protein 0.0043 0.0261 0.0942
Loa Loa (eye worm) hypothetical protein 0.013 0.1159 0.2741
Trypanosoma brucei cytosolic malate dehydrogenase 0.0043 0.0254 0.0915
Loa Loa (eye worm) malate dehydrogenase 0.0043 0.0254 0.0601
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0195 0.0704
Onchocerca volvulus Matrilysin homolog 0.013 0.1159 0.2652
Onchocerca volvulus Alhambra homolog 0.0029 0.0107 0.0133
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0074 0.0265
Trichomonas vaginalis aldo-keto reductase, putative 0.0285 0.2774 1
Mycobacterium leprae PROBABLE HYDROLASE 0.0158 0.1453 0.3287
Onchocerca volvulus 0.0285 0.2774 0.652

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3696 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.1095 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 16.3535 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 18.3489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 26.8545 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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