Detailed information for compound 1383256

Basic information

Technical information
  • TDR Targets ID: 1383256
  • Name: N,N-diethyl-2-(4-ethylphenoxy)acetamide
  • MW: 235.322 | Formula: C14H21NO2
  • H donors: 0 H acceptors: 1 LogP: 2.95 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)OCC(=O)N(CC)CC
  • InChi: 1S/C14H21NO2/c1-4-12-7-9-13(10-8-12)17-11-14(16)15(5-2)6-3/h7-10H,4-6,11H2,1-3H3
  • InChiKey: IGWLKYXDUZZRGO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N,N-diethyl-2-(4-ethylphenoxy)ethanamide
  • ZINC03212859
  • T0500-6100
  • MLS001018125
  • SMR000354365
  • Enamine_000058

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable reductase 0.0225 0.0424 0.3052
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.0192 0.1358
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0034 0.0226
Brugia malayi hypothetical protein 0.0018 0.0007 0.0044
Trichomonas vaginalis glutaminase, putative 0.0533 0.1041 1
Brugia malayi CXXC zinc finger family protein 0.0056 0.0084 0.0557
Plasmodium falciparum glutathione reductase 0.0099 0.017 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0044
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0017 0.0087
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.025 0.0474 0.342
Mycobacterium tuberculosis Probable dehydrogenase 0.0225 0.0424 0.3052
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0051 0.1471
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0099 0.017 0.1138
Loa Loa (eye worm) acetyltransferase 0.0141 0.0254 0.1703
Brugia malayi hypothetical protein 0.015 0.0273 0.1833
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0192 0.1219
Loa Loa (eye worm) hypothetical protein 0.0057 0.0086 0.0576
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0013 0.0081
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0039 0.0246
Loa Loa (eye worm) RNA binding protein 0.0397 0.0769 0.516
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0028 0.0175
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0005 0.0029
Schistosoma mansoni Smad4 0.0023 0.0018 0.011
Schistosoma mansoni microtubule-associated protein tau 0.0668 0.1313 0.8385
Schistosoma mansoni hypothetical protein 0.054 0.1055 0.6738
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.015 0.0273 0.1743
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.015 0.0273 0.0273
Onchocerca volvulus 0.0056 0.0084 0.2831
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.025 0.0474 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0005 0.0277
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0044
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.0192 0.1738
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0029 0.0174
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0015 0.0068
Brugia malayi Muscleblind-like protein 0.018 0.0334 0.2237
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0039 0.0038
Loa Loa (eye worm) MH2 domain-containing protein 0.0052 0.0075 0.0499
Brugia malayi latrophilin 2 splice variant baaae 0.0214 0.04 0.2685
Schistosoma mansoni survival motor neuron protein 0.0052 0.0075 0.0477
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0034 0.004 0.1882
Echinococcus multilocularis muscleblind protein 1 0.018 0.0334 0.0333
Schistosoma mansoni thyroid hormone receptor 0.0159 0.029 0.1848
Schistosoma mansoni nuclear receptor 0.0016 0.0003 0.0018
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.0003 0.0003
Leishmania major trypanothione reductase 0.0099 0.017 0.8837
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0258
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.0192 0.1358
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0093 0.0587
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0017 0.0106
Echinococcus multilocularis smad 0.0052 0.0075 0.0074
Onchocerca volvulus 0.0058 0.0089 0.3001
Brugia malayi glutaminase DH11.1 0.0533 0.1041 0.6992
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0241 0.0454 0.2899
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0039 0.0258
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0093
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0017 0.1167
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0192 0.1738
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0013 0.0666
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.004 0.1882
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.0222 0.0222
Loa Loa (eye worm) Smad1 0.0052 0.0075 0.0499
Loa Loa (eye worm) nuclear hormone receptor 0.0016 0.0003 0.0019
Brugia malayi nuclear receptor NHR-88 0.0016 0.0003 0.0019
Schistosoma mansoni hypothetical protein 0.0099 0.017 0.1082
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0241 0.0454 0.2899
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0005 0.0005
Loa Loa (eye worm) thioredoxin reductase 0.0099 0.017 0.1137
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0005 0.0029
Brugia malayi MH1 domain containing protein 0.0052 0.0075 0.0499
Schistosoma mansoni neuropeptide receptor 0.0487 0.0948 0.6054
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0005 0.0005
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0051 0.005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0241 0.0454 0.2899
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.0003 0.0003
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0055 0.0345
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.004 0.1882
Schistosoma mansoni zinc finger protein 0.0016 0.0003 0.0018
Echinococcus granulosus dna polymerase kappa 0.002 0.0013 0.0077
Echinococcus granulosus microtubule associated protein 2 0.0668 0.1313 0.8385
Onchocerca volvulus 0.0016 0.0003 0.0095
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0118 0.0209 0.1331
Onchocerca volvulus 0.011 0.0192 0.6518
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0258
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0039 0.0258
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0034 0.004 0.1882
Echinococcus granulosus thioredoxin glutathione reductase 0.0099 0.0171 0.1088
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0666
Onchocerca volvulus 0.0034 0.0039 0.1313
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0013 0.0666
Brugia malayi Calcitonin receptor-like protein seb-1 0.0312 0.0599 0.4018
Mycobacterium leprae conserved hypothetical protein 0.011 0.0192 0.3649
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0029 0.0627
Schistosoma mansoni lamin 0.0058 0.0089 0.0561
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.004 0.2106
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0005 0.0031
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0044
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0093 0.0587
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0241 0.0454 0.2899
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0044
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0012 0.0051
Loa Loa (eye worm) hypothetical protein 0.0214 0.04 0.2685
Brugia malayi hypothetical protein 0.016 0.0293 0.1967
Echinococcus granulosus smad 0.0052 0.0075 0.0475
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0055 0.0408
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.004 0.1882
Loa Loa (eye worm) hypothetical protein 0.011 0.0192 0.1282
Brugia malayi Smad1 0.0052 0.0075 0.0499
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0034 0.004 0.1882
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0039 0.0038
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.0192 0.1358
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0017 0.0641
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0039 0.0258
Schistosoma mansoni tar DNA-binding protein 0.0397 0.0769 0.4906
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0093 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0666
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0051 0.0373
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0006 0.0038
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0241 0.0454 0.2899
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0312 0.0599 0.4018
Onchocerca volvulus 0.0016 0.0003 0.0095
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.0254 0.1703
Echinococcus multilocularis lamin dm0 0.0058 0.0089 0.0088
Echinococcus granulosus muscleblind protein 0.018 0.0334 0.2127
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0039 0.0258
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0084 0.0557
Echinococcus granulosus lamin dm0 0.0058 0.0089 0.0561
Mycobacterium ulcerans beta-lactamase 0.011 0.0192 0.1738
Echinococcus multilocularis dna polymerase kappa 0.002 0.0013 0.0012
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0017 0.0111
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0258
Echinococcus granulosus lamin 0.0058 0.0089 0.0561
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0005 0.0005
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0003 0.0018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0241 0.0454 0.0454
Brugia malayi mothers against decapentaplegic homolog 3 0.0023 0.0018 0.0115
Echinococcus multilocularis thyroid hormone receptor alpha 0.0159 0.029 0.0289
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0029 0.0159
Loa Loa (eye worm) hypothetical protein 0.016 0.0293 0.1967
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Schistosoma mansoni transcription factor LCR-F1 0.015 0.0273 0.1743
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0191
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0093 0.0637
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0666
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0023 0.0018 0.0586
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0003 0.0003
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0039 0.0038
Brugia malayi beta-lactamase family protein 0.011 0.0192 0.1282
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.0192 0.1738
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0099 0.017 0.1082
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0012 0.0051
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0029 0.0159
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0039 0.0258
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0093
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0029 0.0191
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0039 0.0258
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0029 0.0191
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.004 0.1882
Echinococcus multilocularis mothers against decapentaplegic 6 0.0023 0.0018 0.0017
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0051 0.005
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0034 0.004 0.0268
Plasmodium vivax glutathione reductase, putative 0.0099 0.017 0.8837
Echinococcus multilocularis G protein coupled receptor 139 0.0487 0.0948 0.0948
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0039 0.0258
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0028 0.0027
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0241 0.0454 0.0454
Loa Loa (eye worm) nuclear receptor NHR-67 0.0016 0.0003 0.0019
Schistosoma mansoni hypothetical protein 0.015 0.0273 0.1743
Loa Loa (eye worm) intermediate filament protein 0.0058 0.0089 0.059
Loa Loa (eye worm) hypothetical protein 0.0028 0.0028 0.0184
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.0003 0.0018
Plasmodium vivax thioredoxin reductase, putative 0.0099 0.017 0.8837
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0029 0.1278
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0013 0.0012
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0093 0.0121
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.004 0.1882
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0192 0.1738
Echinococcus granulosus geminin 0.054 0.1055 0.6738
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0039 0.0246
Schistosoma mansoni thyroid hormone receptor 0.0159 0.029 0.1848
Loa Loa (eye worm) beta-lactamase 0.011 0.0192 0.1282
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0029 0.0159
Brugia malayi nuclear receptor NHR-67 0.0016 0.0003 0.0019
Loa Loa (eye worm) MH2 domain-containing protein 0.0023 0.0018 0.0115
Trypanosoma brucei unspecified product 0.002 0.0013 0.0666
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0017 0.0725
Loa Loa (eye worm) glutathione reductase 0.0099 0.017 0.1137
Schistosoma mansoni nuclear receptor nhr-48 0.0016 0.0003 0.0018
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0039 0.0038
Echinococcus multilocularis musashi 0.0058 0.0089 0.0088
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0013 0.04
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0039 0.0258
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0192 0.1738
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0029 0.0159
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0039 0.0258
Schistosoma mansoni lamin 0.0058 0.0089 0.0561
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0017 0.09
Loa Loa (eye worm) hypothetical protein 0.018 0.0334 0.2237
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0022 0.0144
Echinococcus multilocularis survival motor neuron protein 1 0.0253 0.048 0.0479
Onchocerca volvulus 0.011 0.0192 0.6518
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0034 0.004 0.0266
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0007 0.0042
Echinococcus multilocularis lamin 0.0058 0.0089 0.0088
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0006 0.0006
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0029 0.0159
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0039 0.0258
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0005 0.0005
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0005 0.0031
Loa Loa (eye worm) hypothetical protein 0.004 0.0051 0.0339
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0029 0.1278
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0192 0.1738
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.004 0.1882
Echinococcus multilocularis dnaJ subfamily B 0.0794 0.1566 0.1565
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0039 0.0246
Brugia malayi isocitrate dehydrogenase 0.0017 0.0005 0.0031
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0007 0.0044
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.004 0.1882
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0039 0.0258
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0051 0.246
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0013 0.04
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0666
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0039 0.0258
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0241 0.0454 0.3049
Loa Loa (eye worm) hypothetical protein 0.0058 0.0089 0.059
Loa Loa (eye worm) hypothetical protein 0.011 0.0192 0.1282
Schistosoma mansoni smad 0.0052 0.0075 0.0475
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0241 0.0454 0.3049
Brugia malayi steroid hormone receptor 0.0034 0.0039 0.0258
Loa Loa (eye worm) nuclear factor I 0.0028 0.0029 0.0189
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0093
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0017 0.0641
Entamoeba histolytica hypothetical protein 0.015 0.0273 1
Echinococcus multilocularis muscleblind protein 0.018 0.0334 0.0333
Brugia malayi TAR-binding protein 0.0397 0.0769 0.516
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0029 0.0159
Brugia malayi RNA recognition motif domain containing protein 0.0397 0.0769 0.516
Echinococcus granulosus mothers against decapentaplegic 5 0.0052 0.0075 0.0475
Brugia malayi MH1 domain containing protein 0.0028 0.0029 0.0189
Onchocerca volvulus 0.0058 0.0089 0.3001
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0666
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.0192 0.1358
Brugia malayi RNA binding protein 0.0397 0.0769 0.516
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0029 0.0627
Trypanosoma brucei hypothetical protein, conserved 0.011 0.0192 1
Echinococcus granulosus intermediate filament protein 0.0058 0.0089 0.0561
Schistosoma mansoni hypothetical protein 0.0099 0.017 0.1082
Entamoeba histolytica hypothetical protein 0.015 0.0273 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0013 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0039 0.0258
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0039 0.0038
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0225 0.0424 0.3052
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0012 0.0051
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0093 0.0776
Plasmodium falciparum thioredoxin reductase 0.0099 0.017 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0005 0.0005
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0099 0.017 0.0169
Schistosoma mansoni ap endonuclease 0.0023 0.0017 0.0106
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0666
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0039 0.0038
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Echinococcus granulosus tar DNA binding protein 0.0397 0.0769 0.4906
Giardia lamblia NADH oxidase lateral transfer candidate 0.0034 0.004 0.7193
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0051 0.0322
Entamoeba histolytica hypothetical protein 0.015 0.0273 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0017 0.0111
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0017 0.0641
Schistosoma mansoni intermediate filament proteins 0.0058 0.0089 0.0561
Echinococcus granulosus neuropeptide receptor 0.0487 0.0948 0.6054
Schistosoma mansoni hypothetical protein 0.054 0.1055 0.6738
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.0192 0.1282
Schistosoma mansoni smad1 5 8 and 0.0052 0.0075 0.0475
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0093 0.4687
Trichomonas vaginalis esterase, putative 0.011 0.0192 0.1738
Plasmodium falciparum thioredoxin reductase 0.0034 0.004 0.2129
Schistosoma mansoni tar DNA-binding protein 0.0397 0.0769 0.4906
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0015 0.0018
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.004 0.1882
Mycobacterium ulcerans glutaminase 0.0533 0.1041 1
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0192 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0051 0.2669
Toxoplasma gondii exonuclease III APE 0.0023 0.0017 0.0017
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0016 0.0003 0.0018
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Loa Loa (eye worm) transcription factor SMAD2 0.0756 0.1489 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0039 0.0038
Echinococcus granulosus GPCR family 2 0.0099 0.017 0.1082
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.0003 0.0018
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0013 0.0077
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0192 0.1219
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0666
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0051 1
Treponema pallidum NADH oxidase 0.0034 0.004 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0052 0.0075 0.0074
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0034 0.004 0.0253
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0013 0.04
Schistosoma mansoni tar DNA-binding protein 0.0397 0.0769 0.4906
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.004 0.2106
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0006 0.0036
Schistosoma mansoni hypothetical protein 0.0099 0.017 0.1082
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0034 0.004 0.0253
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0666
Schistosoma mansoni glutaminase 0.0533 0.1041 0.6649
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0003 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0051 0.0373
Loa Loa (eye worm) hypothetical protein 0.0099 0.017 0.1138
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.004 0.1882
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0192 0.1738
Brugia malayi nuclear hormone receptor 0.0034 0.0039 0.0258
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0005 0.0277
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0017 0.0172
Schistosoma mansoni cpg binding protein 0.0056 0.0084 0.053
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0039 0.0246
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0039 0.0246
Plasmodium vivax hypothetical protein, conserved 0.011 0.0192 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0099 0.017 0.1138
Echinococcus multilocularis Smad4 0.0052 0.0075 0.0074
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0055 0.0068
Onchocerca volvulus 0.0029 0.0029 0.097
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.025 0.0474 0.342
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0034 0.004 0.0256
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0093
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0225 0.0424 0.8867
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0081
Schistosoma mansoni Smad4 0.0052 0.0075 0.0475
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0051 0.0322
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0039 0.0246
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.004 0.1882
Onchocerca volvulus 0.016 0.0293 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0191
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0039 0.0258
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0034 0.004 0.0268
Loa Loa (eye worm) MH2 domain-containing protein 0.0756 0.1489 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.017
Loa Loa (eye worm) TAR-binding protein 0.0397 0.0769 0.516
Toxoplasma gondii histone lysine methyltransferase SET1 0.0109 0.0191 0.0256
Echinococcus multilocularis mothers against decapentaplegic 2 0.0023 0.0018 0.0017
Brugia malayi nuclear hormone receptor family member odr-7 0.0016 0.0003 0.0019
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.004 0.1882
Mycobacterium tuberculosis Conserved protein 0.011 0.0192 0.1358
Echinococcus multilocularis mothers against decapentaplegic 5 0.0052 0.0075 0.0074
Brugia malayi MH2 domain containing protein 0.0756 0.1489 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0039 0.1313
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0258
Loa Loa (eye worm) hypothetical protein 0.011 0.0192 0.1282
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0029 0.1278
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0225 0.0424 0.3052
Loa Loa (eye worm) hypothetical protein 0.011 0.0192 0.1282
Schistosoma mansoni smad1 5 8 and 0.0052 0.0075 0.0475
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.0039 0.0246
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0034 0.004 0.2129
Echinococcus multilocularis cpg binding protein 0.0059 0.009 0.0089
Brugia malayi Thioredoxin reductase 0.0099 0.017 0.1137
Echinococcus granulosus Smad4 0.0052 0.0075 0.0475
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0093 0.0776
Brugia malayi MH1 domain containing protein 0.0028 0.0029 0.0189
Brugia malayi hypothetical protein 0.0016 0.0003 0.0019
Mycobacterium tuberculosis Possible penicillin-binding protein 0.07 0.1377 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0039 0.0246
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0258
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0099 0.017 0.1082
Schistosoma mansoni hypothetical protein 0.0099 0.017 0.1082
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.0254 0.0253
Onchocerca volvulus 0.0052 0.0075 0.2548
Schistosoma mansoni hypothetical protein 0.0052 0.0075 0.0477
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0003 0.0018
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0034 0.004 0.0048
Brugia malayi ecdysteroid receptor 0.0034 0.0039 0.0258
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0051 0.005
Mycobacterium tuberculosis Conserved protein 0.011 0.0192 0.1358
Mycobacterium tuberculosis Conserved protein 0.011 0.0192 0.1358
Echinococcus granulosus mothers against decapentaplegic 6 0.0023 0.0018 0.011
Echinococcus granulosus TGF beta signal transducer SmadC 0.0052 0.0075 0.0475
Schistosoma mansoni tar DNA-binding protein 0.0397 0.0769 0.4906
Echinococcus multilocularis geminin 0.054 0.1055 0.1055
Leishmania major DNA polymerase kappa, putative 0.002 0.0013 0.04
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0007 0.0042
Loa Loa (eye worm) MH1 domain-containing protein 0.0023 0.0018 0.0115
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.0192 0.1282
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0666
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0003 0.0019
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.0192 0.1358
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0029 0.0174
Trichomonas vaginalis glutathione reductase, putative 0.0034 0.004 0.0268
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0003 0.0095
Loa Loa (eye worm) MH1 domain-containing protein 0.0052 0.0075 0.0499
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0039 0.0246
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0048 0.2582
Brugia malayi orphan nuclear receptor NR2E1 0.0016 0.0003 0.0019
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0044
Schistosoma mansoni hypothetical protein 0.0214 0.04 0.2553
Trichomonas vaginalis mercuric reductase, putative 0.0034 0.004 0.0268
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0039 0.0246
Loa Loa (eye worm) hypothetical protein 0.0312 0.0599 0.4018
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0051 0.246
Echinococcus granulosus cpg binding protein 0.0059 0.009 0.057
Loa Loa (eye worm) hypothetical protein 0.011 0.0192 0.1282
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0225 0.0424 0.3052
Loa Loa (eye worm) hypothetical protein 0.0253 0.048 0.3219
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.0222 0.1416
Loa Loa (eye worm) hypothetical protein 0.018 0.0334 0.2237
Brugia malayi nuclear hormone receptor 0.0016 0.0003 0.0019
Loa Loa (eye worm) hypothetical protein 0.011 0.0192 0.1282
Loa Loa (eye worm) glutaminase 0.0533 0.1041 0.6992
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0007 0.0042
Leishmania major hypothetical protein, conserved 0.011 0.0192 1
Echinococcus multilocularis tar DNA binding protein 0.0397 0.0769 0.0768
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0039 0.0246
Echinococcus granulosus dna polymerase eta 0.002 0.0013 0.0077
Brugia malayi MH1 domain containing protein 0.0052 0.0075 0.0499
Toxoplasma gondii 1,3-beta-glucan synthase component protein 0.3619 0.7236 1
Schistosoma mansoni smad1 5 8 and 0.0052 0.0075 0.0475
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0039 0.0258
Echinococcus granulosus dnaJ subfamily B 0.0794 0.1566 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0034 0.004 0.2129
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0007 0.0044
Brugia malayi ecdysone receptor 0.0016 0.0003 0.0019
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0055 0.2653
Schistosoma mansoni Smad4 0.0023 0.0018 0.011
Brugia malayi glutathione reductase 0.0099 0.017 0.1137
Mycobacterium ulcerans hypothetical protein 0.0029 0.0029 0.0159
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0013 0.0666
Mycobacterium tuberculosis Probable hydrolase 0.011 0.0192 0.1358
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0055 0.0408
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0039 0.0246
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0051 0.0339
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0192 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0034 0.004 1
Echinococcus multilocularis neuropeptide receptor 0.0487 0.0948 0.0948
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0039 0.0246
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0052 0.0075 0.0475
Mycobacterium ulcerans lipase LipD 0.011 0.0192 0.1738
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0039 0.0258
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0051 0.0322
Entamoeba histolytica hypothetical protein 0.015 0.0273 1
Echinococcus multilocularis microtubule associated protein 2 0.0668 0.1313 0.1313
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0017 0.0044
Mycobacterium leprae Probable lipase LipE 0.011 0.0192 0.3649
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0312 0.0599 0.4018
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.004 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0039 0.0258
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0034 0.004 0.2106
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0003 0.0018
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0022 0.0144
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0225 0.0424 0.3052
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0016 0.0003 0.0019
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0029 0.0159
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0016 0.0003 0.0003
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0034 0.0226
Onchocerca volvulus 0.011 0.0192 0.6518
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0093 0.0776
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0006 0.0035
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0039 0.0246
Loa Loa (eye worm) hypothetical protein 0.0028 0.0029 0.0189
Schistosoma mansoni DNA polymerase eta 0.002 0.0013 0.0077
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0048 0.9136
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.0089 0.059
Brugia malayi MH2 domain containing protein 0.0023 0.0018 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0039 0.0258
Brugia malayi Latrophilin receptor protein 2 0.0099 0.017 0.1138
Trypanosoma brucei trypanothione reductase 0.0099 0.017 0.8869
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.0003 0.0018
Echinococcus multilocularis thioredoxin glutathione reductase 0.0099 0.0171 0.017
Mycobacterium ulcerans hypothetical protein 0.011 0.0192 0.1738
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0013 0.0054
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0075 0.0501
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.0192 0.0191
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0013 0.04
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0039 0.0038
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0013 0.04
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0029 0.0627
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0039 0.0258
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0039 0.0258
Mycobacterium tuberculosis Probable oxidoreductase 0.025 0.0474 0.342
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0051 0.246
Leishmania major DNA polymerase eta, putative 0.002 0.0013 0.04
Toxoplasma gondii ABC1 family protein 0.011 0.0192 0.0258
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.0089 0.059
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.017
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.0039 0.0246
Loa Loa (eye worm) hypothetical protein 0.0021 0.0015 0.0093
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0051 0.0322
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0051 0.0322
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0258
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0048 0.1344
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0007 0.0044
Brugia malayi nuclear receptor RXR 0.0018 0.0007 0.0044
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0017 0.0017
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0397 0.0769 0.516
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0039 0.0246
Trypanosoma cruzi trypanothione reductase, putative 0.0099 0.017 0.8837
Echinococcus granulosus mothers against decapentaplegic 2 0.0023 0.0018 0.011
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0016 0.0003 0.0019
Schistosoma mansoni coup transcription factor 0.0034 0.0039 0.0246
Brugia malayi tailless protein 0.0016 0.0003 0.0019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0039 0.0246
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0017 0.0641
Echinococcus multilocularis GPCR, family 2 0.0099 0.017 0.0169
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Brugia malayi intermediate filament protein 0.0058 0.0089 0.059
Loa Loa (eye worm) DR-78 0.0016 0.0003 0.0019
Schistosoma mansoni cpg binding protein 0.0059 0.009 0.057
Schistosoma mansoni nuclear receptor 0.0016 0.0003 0.0018
Loa Loa (eye worm) glutaminase 2 0.0533 0.1041 0.6992
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0034 0.004 0.2106
Brugia malayi MH2 domain containing protein 0.0052 0.0075 0.0499
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0099 0.017 0.0169
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.004 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0016 0.0003 0.0018
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0051 0.0373
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0039 0.0258
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0012 0.0051
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0003 0.0018
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0055 0.0068
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0003 0.0003
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0039 0.0246
Brugia malayi nuclear hormone receptor family member nhr-6 0.0016 0.0003 0.0019
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0029 0.0191
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0039 0.0258
Brugia malayi conserved hypotetical protein 0.0016 0.0003 0.0019
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.0039 0.1313
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0034 0.004 0.1882
Toxoplasma gondii NADPH-glutathione reductase 0.0034 0.004 0.0048
Brugia malayi nuclear receptor RXR 0.0016 0.0003 0.0019
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0013 0.0054
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0013 0.0077
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0039 0.0258
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0115
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0017 0.0044
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0013 0.0666
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0013 0.0081
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0039 0.0246
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0015 0.0564
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0034 0.004 0.004
Schistosoma mansoni hypothetical protein 0.0125 0.0222 0.1416
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Toxoplasma gondii thioredoxin reductase 0.0099 0.017 0.0228
Brugia malayi beta-lactamase 0.011 0.0192 0.1282
Brugia malayi hypothetical protein 0.0018 0.0007 0.0044
Echinococcus granulosus survival motor neuron protein 1 0.0253 0.048 0.3061
Brugia malayi hypothetical protein 0.0016 0.0003 0.0019
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0013 0.04
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0258
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.0254 0.1619
Plasmodium falciparum glutathione reductase 0.0034 0.004 0.2129
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0013 0.0666
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0093 0.0587
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0099 0.017 0.12
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0034 0.004 0.0268
Brugia malayi beta-lactamase family protein 0.011 0.0192 0.1282
Echinococcus multilocularis dna polymerase eta 0.002 0.0013 0.0012
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0013 0.0077
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0015 0.0499
Brugia malayi nuclear receptor NHR-88 0.0034 0.0039 0.0258
Schistosoma mansoni cpg binding protein 0.0059 0.009 0.057
Loa Loa (eye worm) hypothetical protein 0.0034 0.0039 0.0258
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.0192 0.1358
Brugia malayi MH2 domain containing protein 0.0052 0.0075 0.0499
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0003 0.0095
Schistosoma mansoni smad 0.0023 0.0018 0.011
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0039 0.1313
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0039 0.0258
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0003 0.0019
Schistosoma mansoni tar DNA-binding protein 0.0397 0.0769 0.4906
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0246 0.1568
Brugia malayi hypothetical protein 0.0253 0.048 0.3219
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.0191
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.0192 0.1219
Schistosoma mansoni hypothetical protein 0.0794 0.1566 1
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0017 0.0044
Schistosoma mansoni ap endonuclease 0.0023 0.0017 0.0106

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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