Detailed information for compound 1384945

Basic information

Technical information
  • TDR Targets ID: 1384945
  • Name: but-2-enedioic acid; 2-(4-heptylsulfanyl-2,5- dimethoxyphenyl)-N,N-dimethylethanamine
  • MW: 455.608 | Formula: C23H37NO6S
  • H donors: 2 H acceptors: 4 LogP: 2.83 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)/C=C\C(=O)O.CCCCCCCSc1cc(OC)c(cc1OC)CCN(C)C
  • InChi: 1S/C19H33NO2S.C4H4O4/c1-6-7-8-9-10-13-23-19-15-17(21-4)16(11-12-20(2)3)14-18(19)22-5;5-3(6)1-2-4(7)8/h14-15H,6-13H2,1-5H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
  • InChiKey: IZCDQAZLFGWYIB-BTJKTKAUSA-N  


Substructure search Similarity search

Network

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Synonyms

  • but-2-enedioic acid; 2-(4-heptylsulfanyl-2,5-dimethoxy-phenyl)-N,N-dimethyl-ethanamine
  • but-2-enedioic acid; 2-[4-(heptylthio)-2,5-dimethoxyphenyl]-N,N-dimethylethanamine
  • but-2-enedioic acid; 2-[4-(heptylthio)-2,5-dimethoxy-phenyl]ethyl-dimethyl-amine
  • 2-[4-(heptylsulfanyl)-2,5-dimethoxyphenyl]-N,N-dimethylethanamine
  • MLS000543623
  • SMR000162819

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens arachidonate 15-lipoxygenase, type B Starlite/ChEMBL No references
Homo sapiens glucosidase, beta, acid Starlite/ChEMBL No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens EYA transcriptional coactivator and phosphatase 2 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Onchocerca volvulus Glucosylceramidase homolog Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K01104 protein-tyrosine phosphatase [EC3.1.3.48], putative Get druggable targets OG5_129664 All targets in OG5_129664
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni eyes absent homolog Get druggable targets OG5_129664 All targets in OG5_129664
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Brugia malayi O-Glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0694 0.0694
Schistosoma mansoni neuropeptide receptor 0.0161 0.1665 0.1665
Schistosoma mansoni opsin-like receptor 0.0161 0.1665 0.1665
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0041 0.0325 0.0325
Echinococcus granulosus rhodopsin orphan GPCR 0.0161 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.0148 0.1523 0.1523
Loa Loa (eye worm) hypothetical protein 0.0032 0.0222 0.0222
Schistosoma mansoni alpha-glucosidase 0.0169 0.1763 0.1763
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0161 0.1665 0.1665
Schistosoma mansoni hypothetical protein 0.0161 0.1665 0.1665
Echinococcus multilocularis rhodopsin orphan GPCR 0.0161 0.1665 0.1665
Echinococcus granulosus rhodopsin orphan GPCR 0.0161 0.1665 0.1665
Echinococcus granulosus biogenic amine 5HT receptor 0.0161 0.1665 0.1665
Schistosoma mansoni neuropeptide receptor 0.0161 0.1665 0.1665
Echinococcus granulosus peptide allatostatin:somatostatin 0.0161 0.1665 0.1665
Echinococcus granulosus somatostatin receptor 0.0161 0.1665 0.1665
Schistosoma mansoni amine GPCR 0.0161 0.1665 0.1665
Onchocerca volvulus 0.0024 0.013 0.0421
Schistosoma mansoni neuropeptide receptor 0.0161 0.1665 0.1665
Echinococcus granulosus peregrin 0.0014 0.0024 0.0024
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0757 0.0757
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.018 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0038 0.0291 0.0291
Echinococcus granulosus intermediate filament protein 0.0033 0.0228 0.0228
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0353 0.4318
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0353 0.0927
Onchocerca volvulus 0.0161 0.1665 0.5379
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.148 0.148
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.018 0.3092
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3362 1
Schistosoma mansoni intermediate filament proteins 0.0033 0.0228 0.0228
Onchocerca volvulus 0.0161 0.1665 0.5379
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Brugia malayi Dopamine receptor 0.0161 0.1665 0.1665
Echinococcus multilocularis fmrfamide receptor 0.0161 0.1665 0.1665
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0353 0.0927
Onchocerca volvulus 0.0161 0.1665 0.5379
Echinococcus multilocularis musashi 0.0033 0.0228 0.0228
Echinococcus multilocularis neuropeptide receptor A26 0.0716 0.7898 0.7898
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0059 0.0059
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0161 0.1665 0.5379
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0161 0.1665 0.1665
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0757 1
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0028 0.018 0.5
Loa Loa (eye worm) G-protein coupled receptor 0.0161 0.1665 0.1665
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2159 0.6372
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Echinococcus granulosus dro:myosuppressin receptor 0.0161 0.1665 0.1665
Brugia malayi hypothetical protein 0.0024 0.013 0.013
Onchocerca volvulus 0.0033 0.0228 0.0738
Onchocerca volvulus 0.01 0.0989 0.3196
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0161 0.1665 0.1665
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0353 0.0927
Schistosoma mansoni myosin xvIII 0.0161 0.1665 0.1665
Trichomonas vaginalis set domain proteins, putative 0.0288 0.3096 0.9197
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0325 0.0325
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0381 0.0381
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0161 0.1665 0.1665
Echinococcus multilocularis g-protein coupled receptor 0.0161 0.1665 0.1665
Echinococcus multilocularis neuropeptide Y receptor 0.0161 0.1665 0.1665
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.018 0.5
Brugia malayi G protein-coupled receptor F59B2.13 0.0161 0.1665 0.1665
Brugia malayi AKH receptor 0.0161 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.0024 0.013 0.013
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0161 0.1665 0.1665
Echinococcus multilocularis neuropeptide receptor 0.0161 0.1665 0.1665
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0016 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0059 0.0522 0.0522
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.3362 0.3362
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0161 0.1665 0.1665
Brugia malayi Tachykinin-like peptides receptor 99D 0.0161 0.1665 0.1665
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2159 0.6372
Loa Loa (eye worm) hypothetical protein 0.0106 0.1057 0.1057
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0161 0.1665 0.1665
Brugia malayi RE15519p 0.0161 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Brugia malayi GnHR receptor homolog 0.0161 0.1665 0.1665
Echinococcus multilocularis orexin receptor type 2 0.0161 0.1665 0.1665
Echinococcus granulosus neuropeptide Y receptor 0.0161 0.1665 0.1665
Onchocerca volvulus 0.0161 0.1665 0.5379
Schistosoma mansoni alpha-glucosidase 0.0169 0.1763 0.1763
Brugia malayi hypothetical protein 0.0161 0.1665 0.1665
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0161 0.1665 0.1665
Onchocerca volvulus Huntingtin homolog 0.0148 0.1523 0.4919
Loa Loa (eye worm) hypothetical protein 0.0053 0.0463 0.0463
Schistosoma mansoni SET domain protein 0.0042 0.033 0.033
Echinococcus multilocularis rhodopsin orphan GPCR 0.0161 0.1665 0.1665
Schistosoma mansoni cpg binding protein 0.0039 0.03 0.03
Echinococcus granulosus tm gpcr rhodopsin 0.0161 0.1665 0.1665
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.207 0.207
Onchocerca volvulus 0.0038 0.0291 0.094
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0161 0.1665 0.1665
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0757 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0038 0.0291 0.2302
Schistosoma mansoni amine GPCR 0.0161 0.1665 0.1665
Schistosoma mansoni alpha glucosidase 0.0044 0.0353 0.0353
Loa Loa (eye worm) hypothetical protein 0.0015 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Echinococcus granulosus g-protein coupled receptor 0.0161 0.1665 0.1665
Schistosoma mansoni hypothetical protein 0.0018 0.007 0.007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0161 0.1665 0.1665
Brugia malayi hypothetical protein 0.0161 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0161 0.1665 0.1665
Brugia malayi neuropeptide F receptor 0.0161 0.1665 0.1665
Echinococcus granulosus G protein coupled receptor 139 0.0161 0.1665 0.1665
Brugia malayi Dopamine receptor protein 2 0.0161 0.1665 0.1665
Echinococcus granulosus fmrfamide receptor 0.0161 0.1665 0.1665
Brugia malayi Dopamine receptor protein 1 0.0161 0.1665 0.1665
Echinococcus granulosus lamin 0.0033 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0161 0.1665 0.1665
Loa Loa (eye worm) histone methyltransferase 0.0013 0.0013 0.0013
Echinococcus granulosus rhodopsin orphan GPCR 0.0161 0.1665 0.1665
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0757 0.0757
Trypanosoma cruzi ISWI complex protein 0.0018 0.007 0.0349
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.035 0.035
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0904 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0161 0.1665 0.1665
Brugia malayi hypothetical protein 0.0161 0.1665 0.1665
Echinococcus granulosus hypothetical protein 0.0161 0.1665 0.1665
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0038 0.0291 0.0291
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0253 0.0253
Brugia malayi MH2 domain containing protein 0.0144 0.148 0.148
Echinococcus multilocularis somatostatin receptor 0.0161 0.1665 0.1665
Brugia malayi hypothetical protein 0.0161 0.1665 0.1665
Schistosoma mansoni bromodomain containing protein 0.0078 0.0743 0.0743
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.207 0.207
Echinococcus multilocularis peregrin 0.0014 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0042 0.033 0.033
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.0989 0.0989
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0077 0.0077
Onchocerca volvulus 0.0161 0.1665 0.5379
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3362 1
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Echinococcus granulosus g protein coupled receptor 0.0161 0.1665 0.1665
Onchocerca volvulus 0.0161 0.1665 0.5379
Echinococcus granulosus allatostatin A receptor 0.0161 0.1665 0.1665
Brugia malayi Bromodomain containing protein 0.0093 0.0901 0.0901
Echinococcus granulosus zinc finger protein 0.0026 0.015 0.015
Echinococcus granulosus neuropeptide FF receptor 2 0.0161 0.1665 0.1665
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0161 0.1665 0.1665
Echinococcus granulosus GPCR family 2 0.0019 0.0077 0.0077
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0381 0.0381
Echinococcus granulosus tm gpcr rhodopsin 0.0161 0.1665 0.1665
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0077 0.0077
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0353 0.4318
Onchocerca volvulus 0.0033 0.0228 0.0738
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.3362 0.3362
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0015 0.003 0.003
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0161 0.1665 0.1665
Brugia malayi hypothetical protein 0.0161 0.1665 0.1665
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0757 0.0757
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0013 0.0013 0.0013
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.0989 0.0989
Plasmodium vivax SET domain protein, putative 0.0038 0.0291 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.013 0.013
Echinococcus granulosus dnaJ subfamily B 0.0494 0.5404 0.5404
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0353 0.0353
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0161 0.1665 0.1665
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0353 0.3588
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0757 1
Schistosoma mansoni hypothetical protein 0.0019 0.0077 0.0077
Schistosoma mansoni opsin-like receptor 0.0161 0.1665 0.1665
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3362 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0161 0.1665 0.1665
Brugia malayi Melatonin receptor type 1A 0.0161 0.1665 0.1665
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0094 0.0094
Echinococcus multilocularis rhodopsin orphan GPCR 0.0161 0.1665 0.1665
Brugia malayi Bromodomain containing protein 0.0046 0.0382 0.0382
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.013 0.013
Echinococcus multilocularis g protein coupled receptor 0.0161 0.1665 0.1665
Trypanosoma brucei glucosidase, putative 0.0044 0.0353 0.4318
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0161 0.1665 0.1665
Schistosoma mansoni lamin 0.0033 0.0228 0.0228
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2159 0.6372
Entamoeba histolytica hypothetical protein 0.0028 0.018 0.1888
Echinococcus granulosus g protein coupled receptor 0.0161 0.1665 0.1665
Schistosoma mansoni hypothetical protein 0.0025 0.0143 0.0143
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0522 0.0522
Brugia malayi ORL1-like opioid receptor 0.0161 0.1665 0.1665
Schistosoma mansoni hypothetical protein 0.0161 0.1665 0.1665
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0028 0.018 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3362 1
Brugia malayi putative neuropeptide receptor 0.0161 0.1665 0.1665
Echinococcus multilocularis rhodopsin orphan GPCR 0.0161 0.1665 0.1665
Schistosoma mansoni neuropeptide receptor 0.0161 0.1665 0.1665
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.018 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0161 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.0019 0.0077 0.0077
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0353 0.0927
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0161 0.1665 0.1665
Schistosoma mansoni biogenic amine receptor 0.0161 0.1665 0.1665
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0252 0.0252
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0228 0.0228
Onchocerca volvulus Huntingtin homolog 0.0148 0.1523 0.4919
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0076 0.0718 0.0718
Schistosoma mansoni hypothetical protein 0.0024 0.013 0.013
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0161 0.1665 0.1665
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0757 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0161 0.1665 0.1665
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0161 0.1665 0.1665
Echinococcus multilocularis GPCR, family 2 0.0019 0.0077 0.0077
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0039 0.0039
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0161 0.1665 0.1665
Echinococcus granulosus tm gpcr rhodopsin 0.0161 0.1665 0.1665
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0161 0.1665 0.1665
Echinococcus multilocularis lamin 0.0033 0.0228 0.0228
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.0989 0.0989
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Schistosoma mansoni loxhd1 0.0024 0.013 0.013
Echinococcus granulosus 7TM GPCR rhodopsin 0.0161 0.1665 0.1665
Echinococcus granulosus lamin dm0 0.0033 0.0228 0.0228
Echinococcus granulosus biogenic amine 5HT receptor 0.0161 0.1665 0.1665
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0353 0.0353
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0522 0.0522
Echinococcus granulosus neuropeptide s receptor 0.0716 0.7898 0.7898
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Brugia malayi hypothetical protein 0.0161 0.1665 0.1665
Onchocerca volvulus 0.0161 0.1665 0.5379
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Echinococcus granulosus neuropeptides capa receptor 0.0161 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0077 0.0077
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0904 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0161 0.1665 0.1665
Schistosoma mansoni adenoreceptor 0.0161 0.1665 0.1665
Loa Loa (eye worm) TYRA-2 protein 0.0161 0.1665 0.1665
Onchocerca volvulus 0.0035 0.0252 0.0815
Onchocerca volvulus 0.0161 0.1665 0.5379
Echinococcus multilocularis RUN 0.0024 0.013 0.013
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3362 1
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Schistosoma mansoni growth hormone secretagogue receptor 0.0161 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.0148 0.1523 0.1523
Onchocerca volvulus 0.0161 0.1665 0.5379
Echinococcus granulosus orexin receptor type 2 0.0161 0.1665 0.1665
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0191 0.0191
Toxoplasma gondii histone lysine methyltransferase SET1 0.0071 0.0662 1
Brugia malayi G protein-coupled receptor 0.0161 0.1665 0.1665
Echinococcus multilocularis zinc finger protein 0.0026 0.015 0.015
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0028 0.018 0.5
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0757 0.0757
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.0016 0.0045 0.0045
Echinococcus multilocularis cpg binding protein 0.0039 0.03 0.03
Onchocerca volvulus 0.0114 0.114 0.3682
Loa Loa (eye worm) hypothetical protein 0.006 0.0538 0.0538
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0077 0.0077
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.148 0.148
Onchocerca volvulus Neuropeptide F receptor homolog 0.0161 0.1665 0.5379
Brugia malayi CXXC zinc finger family protein 0.0035 0.0252 0.0252
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0161 0.1665 0.1665
Schistosoma mansoni SET domain protein 0.0019 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Trypanosoma brucei ISWI complex protein 0.0018 0.007 0.0349
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0694 0.0694
Brugia malayi hypothetical protein 0.0161 0.1665 0.1665
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.207 0.207
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.1461 0.1461
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Schistosoma mansoni neuropeptide F-like receptor 0.0161 0.1665 0.1665
Schistosoma mansoni neuropeptide f receptor 76f 0.0161 0.1665 0.1665
Brugia malayi hypothetical protein 0.0024 0.013 0.013
Schistosoma mansoni biogenic amine (5HT) receptor 0.0161 0.1665 0.1665
Echinococcus granulosus neuropeptide receptor A26 0.0716 0.7898 0.7898
Schistosoma mansoni hypothetical protein 0.0019 0.0077 0.0077
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0161 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.013 0.013
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0161 0.1665 0.1665
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0059 0.0059
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.018 0.1888
Schistosoma mansoni hypothetical protein 0.0041 0.0325 0.0325
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0353 0.4318
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0228 0.0228
Schistosoma mansoni serine/threonine protein kinase 0.0904 1 1
Brugia malayi hypothetical protein 0.0161 0.1665 0.1665
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0191 0.0191
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0143 0.0143
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0161 0.1665 0.1665
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0045 0.0045
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0353 0.4318
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0077 0.0077
Brugia malayi neuropeptide F receptor 0.0161 0.1665 0.1665
Echinococcus multilocularis g protein coupled receptor 0.0161 0.1665 0.1665
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0161 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Onchocerca volvulus 0.0161 0.1665 0.5379
Brugia malayi PHD-finger family protein 0.0032 0.0223 0.0223
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0253 0.2706 0.2706
Schistosoma mansoni zinc finger protein 0.0026 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0046 0.0383 0.0383
Onchocerca volvulus 0.0161 0.1665 0.5379
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Echinococcus multilocularis neuropeptide s receptor 0.0716 0.7898 0.7898
Echinococcus multilocularis neuropeptide receptor 0.0161 0.1665 0.1665
Echinococcus multilocularis fmrfamide receptor 0.0161 0.1665 0.1665
Echinococcus granulosus neuropeptide receptor 0.0161 0.1665 0.1665
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0161 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Onchocerca volvulus 0.0161 0.1665 0.5379
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0161 0.1665 0.1665
Echinococcus granulosus 7tm_1 domain containing protein 0.0161 0.1665 0.1665
Echinococcus granulosus neuropeptide receptor 0.0161 0.1665 0.1665
Brugia malayi hypothetical protein 0.0161 0.1665 0.1665
Echinococcus granulosus alpha 1A adrenergic receptor 0.0161 0.1665 0.1665
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0161 0.1665 0.1665
Echinococcus multilocularis neuropeptides capa receptor 0.0161 0.1665 0.1665
Brugia malayi Pre-SET motif family protein 0.0253 0.2706 0.2706
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0161 0.1665 0.1665
Echinococcus multilocularis dro:myosuppressin receptor 0.0161 0.1665 0.1665
Onchocerca volvulus 0.0161 0.1665 0.5379
Schistosoma mansoni amine GPCR 0.0161 0.1665 0.1665
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0161 0.1665 0.1665
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0161 0.1665 0.1665
Brugia malayi follicle stimulating hormone receptor 0.0161 0.1665 0.1665
Brugia malayi Doublecortin family protein 0.0024 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0106 0.1057 0.1057
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0161 0.1665 0.1665
Echinococcus multilocularis g protein coupled receptor 0.0161 0.1665 0.1665
Schistosoma mansoni amine GPCR 0.0161 0.1665 0.1665
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0353 0.0927
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0538 0.0538
Onchocerca volvulus 0.0288 0.3096 1
Onchocerca volvulus 0.0161 0.1665 0.5379
Echinococcus granulosus g protein coupled receptor 0.0161 0.1665 0.1665
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.018 0.1888
Loa Loa (eye worm) hypothetical protein 0.0024 0.013 0.013
Brugia malayi G-protein coupled receptor 0.0161 0.1665 0.1665
Schistosoma mansoni alpha-1 adrenergic receptor 0.0161 0.1665 0.1665
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0904 1 1
Schistosoma mansoni lipoxygenase 0.0142 0.1461 0.1461
Brugia malayi putative neuropeptide receptor NPR1 0.0161 0.1665 0.1665
Echinococcus multilocularis rhodopsin orphan GPCR 0.0161 0.1665 0.1665
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.1461 0.1461
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0042 0.033 0.033
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0015 0.003 0.003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0161 0.1665 0.1665
Onchocerca volvulus 0.0161 0.1665 0.5379
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.3362 1
Echinococcus multilocularis lamin dm0 0.0033 0.0228 0.0228
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0353 0.0927
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.018 0.5
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.013 0.013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0161 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0353 0.0927
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.207 0.207
Loa Loa (eye worm) hypothetical protein 0.0015 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.2282 0.6745
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0013 0.0013 0.0013
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Brugia malayi G-protein coupled receptor 0.0161 0.1665 0.1665
Echinococcus multilocularis rhodopsin orphan GPCR 0.0161 0.1665 0.1665
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0161 0.1665 0.1665
Brugia malayi Serotonin receptor 0.0161 0.1665 0.1665
Schistosoma mansoni histamine h1 receptor 0.0161 0.1665 0.1665
Onchocerca volvulus 0.0161 0.1665 0.5379
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0161 0.1665 0.1665
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2159 0.6372
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2159 0.6372
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0161 0.1665 0.1665
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0161 0.1665 0.1665
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0077 0.0077
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2159 0.6372
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Schistosoma mansoni hypothetical protein 0.0019 0.0077 0.0077
Brugia malayi hypothetical protein 0.0148 0.1523 0.1523
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0161 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0522 0.0522
Onchocerca volvulus 0.0161 0.1665 0.5379
Schistosoma mansoni phd finger protein 0.0014 0.0024 0.0024
Schistosoma mansoni cpg binding protein 0.0039 0.03 0.03
Brugia malayi F/Y-rich N-terminus family protein 0.0016 0.0038 0.0038
Echinococcus multilocularis sex peptide receptor 0.0161 0.1665 0.1665
Brugia malayi Serotonin receptor 0.0161 0.1665 0.1665
Schistosoma mansoni hypothetical protein 0.0161 0.1665 0.1665
Echinococcus granulosus sex peptide receptor 0.0161 0.1665 0.1665
Trypanosoma cruzi ISWI complex protein 0.0018 0.007 0.0349
Schistosoma mansoni neuropeptide F-like receptor 0.0161 0.1665 0.1665
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0161 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.0085 0.0821 0.0821
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0161 0.1665 0.1665
Echinococcus granulosus RUN 0.0024 0.013 0.013
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.035 0.035
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.5404 0.5404
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0161 0.1665 0.1665
Schistosoma mansoni lamin 0.0033 0.0228 0.0228
Schistosoma mansoni amine GPCR 0.0161 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.0033 0.0228 0.0228
Echinococcus multilocularis serotonin receptor 0.0161 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Echinococcus multilocularis rhodopsin orphan GPCR 0.0161 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.0989 0.0989
Schistosoma mansoni hypothetical protein 0.0161 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0161 0.1665 0.1665
Echinococcus multilocularis allatostatin A receptor 0.0161 0.1665 0.1665
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0094 0.0094
Schistosoma mansoni hypothetical protein 0.0494 0.5404 0.5404
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0353 0.0353
Schistosoma mansoni polycystin 1-related 0.0024 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0049 0.0415 0.0415
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0353 0.0927
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0161 0.1665 0.1665
Schistosoma mansoni rab6-interacting 0.0024 0.013 0.013
Brugia malayi hypothetical protein 0.0161 0.1665 0.1665
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0039 0.0039
Echinococcus granulosus cpg binding protein 0.0039 0.03 0.03
Onchocerca volvulus 0.0024 0.013 0.0421
Brugia malayi sulfakinin receptor protein 0.0161 0.1665 0.1665
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.207 0.207
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.2159 0.6974
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0353 0.0927
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0161 0.1665 0.1665
Echinococcus granulosus tachykinin peptides receptor 99D 0.0161 0.1665 0.1665
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0038 0.0291 0.0291
Schistosoma mansoni biogenic amine receptor 0.0161 0.1665 0.1665
Echinococcus multilocularis G protein coupled receptor 139 0.0161 0.1665 0.1665
Brugia malayi larval opioid receptor 0.0161 0.1665 0.1665
Brugia malayi Pre-SET motif family protein 0.0038 0.0291 0.0291
Echinococcus multilocularis G-protein coupled receptor, putative 0.0161 0.1665 0.1665
Loa Loa (eye worm) doublecortin family protein 0.0024 0.013 0.013
Mycobacterium leprae conserved hypothetical protein 0.0028 0.018 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0161 0.1665 0.1665
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0522 0.0522
Echinococcus granulosus rhodopsin orphan GPCR 0.0161 0.1665 0.1665
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0757 0.0757
Echinococcus multilocularis neuropeptide FF receptor 2 0.0161 0.1665 0.1665
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.2159 0.6372
Echinococcus granulosus rhodopsin orphan GPCR 0.0161 0.1665 0.1665
Schistosoma mansoni lipoxygenase 0.01 0.098 0.098
Loa Loa (eye worm) G-protein coupled receptor 0.0161 0.1665 0.1665
Echinococcus granulosus neuropeptide Y receptor 0.0161 0.1665 0.1665
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0757 1
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.2282 0.6745
Brugia malayi hypothetical protein 0.0106 0.1057 0.1057
Echinococcus granulosus rhodopsin orphan GPCR 0.0161 0.1665 0.1665
Loa Loa (eye worm) neuropeptide F receptor 0.0161 0.1665 0.1665
Schistosoma mansoni biogenic amine (5HT) receptor 0.0161 0.1665 0.1665
Echinococcus multilocularis neuropeptide Y receptor 0.0161 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.01 0.0989 0.0989
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.013 0.013
Loa Loa (eye worm) melatonin receptor type 1A 0.0161 0.1665 0.1665
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0016 0.0045 0.0147
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0191 0.0191
Echinococcus granulosus serotonin receptor 0.0161 0.1665 0.1665
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0353 0.4318
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Brugia malayi intermediate filament protein 0.0033 0.0228 0.0228
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0538 0.0538
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0161 0.1665 0.1665
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0353 0.0353
Schistosoma mansoni cpg binding protein 0.0035 0.0252 0.0252
Echinococcus multilocularis serotonin receptor 0.0161 0.1665 0.1665
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.013 0.013
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0161 0.1665 0.1665
Loa Loa (eye worm) hypothetical protein 0.0161 0.1665 0.1665
Leishmania major hypothetical protein, conserved 0.0018 0.007 0.0349
Schistosoma mansoni eyes absent homolog 0.0106 0.1057 0.1057
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0161 0.1665 0.1665
Loa Loa (eye worm) neuropeptide F receptor 0.0161 0.1665 0.1665
Schistosoma mansoni rab6-interacting 0.0024 0.013 0.013
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0538 0.0538
Schistosoma mansoni hypothetical protein 0.0019 0.0077 0.0077
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0094 0.0094
Schistosoma mansoni biogenic amine receptor 0.0161 0.1665 0.1665
Schistosoma mansoni zinc finger protein 0.0018 0.007 0.007
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0161 0.1665 0.1665
Schistosoma mansoni opsin-like receptor 0.0161 0.1665 0.1665

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 20 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485273, AID485343, AID493182] ChEMBL. No reference
IC50 (functional) 44.41 uM PUBCHEM_BIOASSAY: Discovery of Small Molecule Probes for H1N1 Influenza NS1A. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504399] ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 3.6964 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) 4.6535 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.104 uM PubChem BioAssay. qHTS for Inhibitors of the Phosphatase Activity of Eya2: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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