Detailed information for compound 1395243

Basic information

Technical information
  • TDR Targets ID: 1395243
  • Name: [1-oxo-1-[(4-sulfamoylphenyl)amino]butan-2-yl ] 2-(2,3-dioxoindol-1-yl)acetate
  • MW: 445.446 | Formula: C20H19N3O7S
  • H donors: 2 H acceptors: 6 LogP: 1.22 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(C(=O)Nc1ccc(cc1)S(=O)(=O)N)OC(=O)CN1c2ccccc2C(=O)C1=O
  • InChi: 1S/C20H19N3O7S/c1-2-16(19(26)22-12-7-9-13(10-8-12)31(21,28)29)30-17(24)11-23-15-6-4-3-5-14(15)18(25)20(23)27/h3-10,16H,2,11H2,1H3,(H,22,26)(H2,21,28,29)
  • InChiKey: ABSPRDUYQGTBGZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-[(4-sulfamoylphenyl)carbamoyl]propyl 2-(2,3-dioxoindolin-1-yl)acetate
  • 2-(2,3-dioxo-1-indolinyl)acetic acid 1-[oxo-[(4-sulfamoylphenyl)amino]methyl]propyl ester
  • 2-(2,3-diketoindolin-1-yl)acetic acid 1-[(4-sulfamoylphenyl)carbamoyl]propyl ester
  • [1-oxo-1-[(4-sulfamoylphenyl)amino]butan-2-yl] 2-(2,3-dioxoindol-1-yl)ethanoate
  • STK123956
  • 1-({[4-(aminosulfonyl)phenyl]amino}carbonyl)propyl (2,3-dioxo-2,3-dihydro-1H-indol-1-yl)acetate
  • MLS000676686
  • SMR000298347
  • EU-0041324

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens v-ets avian erythroblastosis virus E26 oncogene homolog Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K09435 transcriptional regulator ERG, putative Get druggable targets OG5_131947 All targets in OG5_131947
Schistosoma mansoni ets-related Get druggable targets OG5_131947 All targets in OG5_131947
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Papain family cysteine protease containing protein 0.0064 0.0532 0.0532
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0099 0.0098
Trypanosoma brucei cysteine peptidase C (CPC) 0.0367 0.346 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0124 0.111 0.1098
Brugia malayi Cathepsin L-like precursor 0.0211 0.1957 0.1957
Giardia lamblia Cathepsin B precursor 0.0064 0.0532 0.013
Schistosoma mansoni ets-related 0.0265 0.2479 0.2469
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0013 0.0012
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1045 1 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0064 0.0532 0.0532
Brugia malayi Cathepsin L-like cysteine proteinase 0.0152 0.1379 0.1379
Giardia lamblia Cathepsin L-like protease 0.0064 0.0532 0.013
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0098
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0624 0.0612
Loa Loa (eye worm) cathepsin B 0.0367 0.346 0.3459
Onchocerca volvulus Cathepsin F homolog 0.0211 0.1957 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0567 0.0566
Echinococcus multilocularis expressed protein 0.0369 0.3479 0.3478
Echinococcus granulosus ETS transcription factor Elf 1 0.0013 0.0039 0.0038
Brugia malayi Papain family cysteine protease containing protein 0.0064 0.0532 0.0532
Loa Loa (eye worm) fli-1 protein 0.0265 0.2479 0.2478
Giardia lamblia Cathepsin L precursor 0.0064 0.0532 0.013
Entamoeba histolytica cysteine protease, putative 0.0124 0.111 0.5438
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0013 0.0013
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0099 0.0087
Plasmodium vivax unspecified product 0.0124 0.111 0.4207
Giardia lamblia Cathepsin L precursor 0.0064 0.0532 0.013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0211 0.1957 0.5528
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0099 0.0087
Brugia malayi fibroinase precursor 0.0064 0.0532 0.0532
Loa Loa (eye worm) hypothetical protein 0.0012 0.0036 0.0035
Trypanosoma cruzi major cysteine proteinase, putative 0.0064 0.0532 0.0041
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0211 0.1957 0.5528
Brugia malayi Cathepsin L-like precursor 0.0211 0.1957 0.1957
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0099 0.0087
Entamoeba histolytica cysteine proteinase 1, putative 0.0124 0.111 0.5438
Echinococcus granulosus intermediate filament protein 0.0027 0.0174 0.0173
Entamoeba histolytica cysteine protease, putative 0.0124 0.111 0.5438
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0211 0.1957 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0624 0.5
Loa Loa (eye worm) hypothetical protein 0.0064 0.0532 0.0531
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0099 0.0099
Schistosoma mansoni lamin 0.0027 0.0174 0.0161
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.2672 0.2671
Echinococcus multilocularis cathepsin L cysteine protease 0.0211 0.1957 0.1956
Schistosoma mansoni high-affinity choline transporter 0.0344 0.3234 0.3225
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0624 0.5
Echinococcus granulosus ETS transcription factor Elf 2 0.0013 0.0039 0.0038
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0099 0.0098
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0104 0.0092
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0211 0.1957 0.1956
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0064 0.0532 0.052
Brugia malayi Papain family cysteine protease containing protein 0.0211 0.1957 0.1957
Brugia malayi GH02984p 0.0344 0.3234 0.3234
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0098
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0211 0.1957 0.5528
Echinococcus multilocularis ETS transcription factor Elf 2 0.0013 0.0039 0.0038
Loa Loa (eye worm) hypothetical protein 0.0013 0.0039 0.0038
Loa Loa (eye worm) hypothetical protein 0.0031 0.0217 0.0216
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0013 0.0012
Schistosoma mansoni hypothetical protein 0.0058 0.0478 0.0466
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0217 0.0216
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0532 0.1287
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0258 0.241 0.6461
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0868 0.0868
Loa Loa (eye worm) hypothetical protein 0.0064 0.0532 0.0531
Onchocerca volvulus 0.0211 0.1957 1
Leishmania major cathepsin L-like protease 0.0211 0.1957 0.4935
Schistosoma mansoni intermediate filament proteins 0.0027 0.0174 0.0161
Echinococcus granulosus mitogen activated protein kinase 3 0.006 0.0493 0.0492
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0013 0.0013
Echinococcus granulosus sodium:glucose cotransporter 2 0.0038 0.0282 0.0281
Echinococcus multilocularis cathepsin b 0.1045 1 1
Onchocerca volvulus 0.0028 0.019 0.0914
Brugia malayi steroid hormone receptor 0.001 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0532 0.1287
Schistosoma mansoni cathepsin B (C01 family) 0.0064 0.0532 0.052
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0013 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0013 0.0012
Echinococcus granulosus GA binding protein alpha chain 0.0087 0.076 0.0759
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0013 0.0013
Brugia malayi Ets-domain containing protein 0.0087 0.076 0.076
Echinococcus multilocularis ets variant gene 4 0.0013 0.0039 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0064 0.0532 0.1287
Brugia malayi nuclear receptor NHR-88 0.001 0.0013 0.0013
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0064 0.0532 0.0257
Leishmania major cathepsin L-like protease 0.0258 0.241 0.6461
Brugia malayi cathepsin L-like precursor 0.0152 0.1379 0.1379
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0493 0.1172
Onchocerca volvulus 0.0211 0.1957 1
Echinococcus multilocularis cpg binding protein 0.003 0.0206 0.0205
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0064 0.0532 0.052
Schistosoma mansoni gabp alpha 0.0087 0.076 0.0748
Brugia malayi PXA domain containing protein 0.0019 0.0099 0.0099
Toxoplasma gondii cathepsin CPL 0.0211 0.1957 0.5271
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0099 0.0098
Leishmania major cathepsin L-like protease 0.0211 0.1957 0.4935
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0211 0.1957 0.5528
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0436 0.0483
Schistosoma mansoni hypothetical protein 0.0405 0.382 0.3812
Entamoeba histolytica cysteine protease, putative 0.0124 0.111 0.5438
Schistosoma mansoni cpg binding protein 0.0028 0.019 0.0178
Brugia malayi transcription factor E74 isoform 0.0013 0.0039 0.0039
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0098
Entamoeba histolytica cysteine proteinase, putative 0.0124 0.111 0.5438
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0013 0.0039 0.0038
Onchocerca volvulus 0.0211 0.1957 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0064 0.0532 0.052
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0624 0.5
Brugia malayi hypothetical protein 0.0019 0.0099 0.0099
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0013 0.0012
Schistosoma mansoni cathepsin F (C01 family) 0.0211 0.1957 0.1947
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0124 0.111 0.1098
Schistosoma mansoni cpg binding protein 0.003 0.0206 0.0194
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0099 0.0087
Brugia malayi Sodium:solute symporter family protein 0.0038 0.0282 0.0282
Giardia lamblia Cathepsin L precursor 0.0064 0.0532 0.013
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0124 0.111 0.0648
Loa Loa (eye worm) hypothetical protein 0.0027 0.0174 0.0173
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0064 0.0532 0.0257
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0174 0.0173
Echinococcus granulosus solute carrier family 5 0.0038 0.0282 0.0281
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0258 0.241 0.6461
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0367 0.346 0.3452
Schistosoma mansoni hypothetical protein 0.0031 0.0217 0.0205
Loa Loa (eye worm) hypothetical protein 0.0026 0.0169 0.0168
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.111 0.2078
Loa Loa (eye worm) hypothetical protein 0.0013 0.0039 0.0038
Brugia malayi CXXC zinc finger family protein 0.0028 0.019 0.019
Entamoeba histolytica cysteine protease, putative 0.0064 0.0532 0.2328
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0099 0.0098
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0064 0.0532 0.0257
Loa Loa (eye worm) hypothetical protein 0.0152 0.1379 0.1378
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0211 0.1957 0.1956
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0013 0.0012
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0104 0.0103
Echinococcus multilocularis lamin dm0 0.0027 0.0174 0.0173
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0211 0.1957 0.5528
Schistosoma mansoni cathepsin F (C01 family) 0.0211 0.1957 0.1947
Entamoeba histolytica cysteine protease, putative 0.0124 0.111 0.5438
Echinococcus granulosus ETS transcription factor Elf 2 0.0013 0.0039 0.0038
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0624 0.0441
Brugia malayi cathepsin F-like cysteine proteinase 0.0064 0.0532 0.0532
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0174 0.0173
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0013 0.0012
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0013 0.0012
Leishmania major cathepsin L-like protease 0.0258 0.241 0.6461
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0099 0.0087
Entamoeba histolytica cysteine proteinase, putative 0.0211 0.1957 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0868 0.0867
Loa Loa (eye worm) hypothetical protein 0.0149 0.1359 0.1358
Echinococcus multilocularis ewsr:fli fusion protein type 0.0013 0.0039 0.0038
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0099 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0211 0.1957 0.5528
Echinococcus multilocularis GA binding protein alpha chain 0.0087 0.076 0.0759
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0258 0.241 0.6461
Trypanosoma cruzi cysteine peptidase, putative 0.0258 0.241 0.2016
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0013 0.0013
Brugia malayi Cathepsin L-like precursor 0.0211 0.1957 0.1957
Giardia lamblia Cathepsin B precursor 0.0064 0.0532 0.013
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0624 0.0623
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.0532 0.1287
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0038 0.0282 0.0281
Onchocerca volvulus 0.0211 0.1957 1
Brugia malayi Papain family cysteine protease containing protein 0.0064 0.0532 0.0532
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0099 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0211 0.1957 0.5528
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0064 0.0532 0.0531
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0064 0.0532 0.1287
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0038 0.0282 0.0281
Leishmania major cathepsin L-like protease 0.0211 0.1957 0.4935
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0532 0.1287
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0013 0.0012
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0064 0.0532 0.0257
Echinococcus multilocularis high affinity choline transporter 1 0.0344 0.3234 0.3233
Echinococcus multilocularis cathepsin L 0.0124 0.111 0.1109
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0054 0.0053
Toxoplasma gondii preprocathepsin c precursor, putative 0.0064 0.0532 0.0785
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0013 0.0013
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0013 0.0012
Entamoeba histolytica cysteine protease, putative 0.0124 0.111 0.5438
Trypanosoma cruzi cruzipain precursor, putative 0.0258 0.241 0.2016
Leishmania major cathepsin L-like protease 0.0211 0.1957 0.4935
Brugia malayi intermediate filament protein 0.0027 0.0174 0.0174
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0087 0.076 0.0759
Echinococcus granulosus cathepsin l cysteine peptidase 0.0211 0.1957 0.1956
Echinococcus multilocularis ETS transcription factor Elf 2 0.0013 0.0039 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0258 0.241 0.6461
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0013 0.0012
Entamoeba histolytica cysteine proteinase, putative 0.0124 0.111 0.5438
Schistosoma mansoni ets 0.0013 0.0039 0.0026
Loa Loa (eye worm) hypothetical protein 0.006 0.0494 0.0493
Echinococcus granulosus sodium:myo inositol cotransporter 0.0038 0.0282 0.0281
Brugia malayi Ets-domain containing protein 0.0013 0.0039 0.0039
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0064 0.0532 0.013
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0012
Schistosoma mansoni hypothetical protein 0.0031 0.0217 0.0205
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0013 0.0012
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1045 1 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0013 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0211 0.1957 0.5528
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0064 0.0532 0.0257
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0211 0.1957 0.5528
Brugia malayi Cathepsin L-like precursor 0.0152 0.1379 0.1379
Brugia malayi cathepsin L precursor 0.0064 0.0532 0.0532
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0012
Entamoeba histolytica cysteine proteinase 2 0.0124 0.111 0.5438
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0012
Trypanosoma cruzi cysteine protease, putative 0.0124 0.111 0.0648
Loa Loa (eye worm) hypothetical protein 0.0211 0.1957 0.1956
Giardia lamblia Cathepsin B precursor 0.0367 0.346 1
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0013 0.0013
Giardia lamblia Encystation-specific protease 0.0064 0.0532 0.013
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0064 0.0532 0.0531
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0099 0.0098
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0099 0.0098
Brugia malayi Cathepsin L-like precursor 0.0211 0.1957 0.1957
Echinococcus granulosus ETS domain containing protein Elk 1 0.0013 0.0039 0.0038
Trypanosoma cruzi cysteine peptidase, putative 0.0258 0.241 0.2016
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.006 0.0494 0.0494
Brugia malayi Cathepsin L-like precursor 0.006 0.0494 0.0494
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0211 0.1957 0.5528
Schistosoma mansoni hypothetical protein 0.0067 0.0567 0.0555
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0013 0.0013
Entamoeba histolytica cysteine protease, putative 0.0124 0.111 0.5438
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0211 0.1957 0.5528
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0211 0.1957 0.5528
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0099 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0124 0.111 0.3006
Entamoeba histolytica cysteine protease, putative 0.0064 0.0532 0.2328
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0624 0.0612
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0367 0.346 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0064 0.0532 0.052
Loa Loa (eye worm) hypothetical protein 0.0152 0.1379 0.1378
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0211 0.1957 0.1956
Echinococcus granulosus FTZ F1 alpha 0.001 0.0013 0.0012
Brugia malayi Cathepsin L-like precursor 0.0152 0.1379 0.1379
Onchocerca volvulus 0.0027 0.0174 0.0828
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0099 0.0098
Loa Loa (eye worm) hypothetical protein 0.0064 0.0532 0.0531
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0064 0.0532 0.052
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0493 0.0481
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0064 0.0532 0.1287
Loa Loa (eye worm) cysteine protease 0.0211 0.1957 0.1956
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0567 0.0567
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0211 0.1957 0.5528
Echinococcus multilocularis dnaJ subfamily B 0.0405 0.382 0.382
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0211 0.1957 0.5528
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0258 0.241 0.6461
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0013 0.0012
Leishmania major cathepsin L-like protease 0.0211 0.1957 0.4935
Schistosoma mansoni hypothetical protein 0.0013 0.0039 0.0026
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0624 0.5
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0099 0.0098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0258 0.241 0.6461
Giardia lamblia Hypothetical protein 0.0064 0.0532 0.013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0211 0.1957 0.5528
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0211 0.1957 0.5528
Plasmodium falciparum cysteine proteinase falcipain 1 0.0124 0.111 0.4054
Echinococcus granulosus cathepsin l1 0.0211 0.1957 0.1956
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0099 0.0098
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0012
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0099 0.0087
Loa Loa (eye worm) hypothetical protein 0.1045 1 1
Toxoplasma gondii cathepsin CPC2 0.0064 0.0532 0.0785
Loa Loa (eye worm) hypothetical protein 0.0286 0.2672 0.2671
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0624 0.0623
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0211 0.1957 1
Plasmodium vivax vivapain-2 0.0211 0.1957 1
Echinococcus granulosus cpg binding protein 0.003 0.0206 0.0205
Echinococcus granulosus expressed protein 0.0369 0.3479 0.3478
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0013 0.0013
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0124 0.111 0.1098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0013 0.0012
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0174 0.0174
Brugia malayi Cathepsin L-like precursor 0.0211 0.1957 0.1957
Plasmodium vivax serine-repeat antigen (SERA) 0.0064 0.0532 0.0257
Toxoplasma gondii cathepsin B 0.0367 0.346 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0211 0.1957 0.5528
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0258 0.241 0.6461
Brugia malayi hypothetical protein 0.0019 0.0099 0.0099
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1045 1 1
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0099 0.0087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0013 0.0012
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0868 0.0868
Schistosoma mansoni cathepsin S (C01 family) 0.0064 0.0532 0.052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.1379 0.3809
Loa Loa (eye worm) hypothetical protein 0.0064 0.0532 0.0531
Loa Loa (eye worm) hypothetical protein 0.0038 0.0282 0.0281
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0099 0.0098
Entamoeba histolytica cysteine protease, putative 0.0124 0.111 0.5438
Onchocerca volvulus 0.0038 0.0282 0.1386
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0099 0.0098
Loa Loa (eye worm) hypothetical protein 0.0012 0.0036 0.0035
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0064 0.0532 0.0257
Onchocerca volvulus 0.0211 0.1957 1
Schistosoma mansoni hypothetical protein 0.0013 0.0039 0.0026
Onchocerca volvulus 0.0211 0.1957 1
Trypanosoma cruzi cysteine peptidase, putative 0.0124 0.111 0.0648
Echinococcus granulosus protein C ets 2 0.0013 0.0039 0.0038
Plasmodium vivax vivapain-3 0.0124 0.111 0.4207
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0013 0.0012
Leishmania major cathepsin L-like protease 0.0258 0.241 0.6461
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0013 0.0012
Schistosoma mansoni ets-related 0.0013 0.0039 0.0026
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0493 0.1172
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0211 0.1957 0.5528
Giardia lamblia Cathepsin L precursor 0.0064 0.0532 0.013
Onchocerca volvulus 0.0058 0.0478 0.2395
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0064 0.0532 0.0257
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0104 0.0103
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0099 0.0098
Echinococcus multilocularis ETS transcription factor Elf 1 0.0013 0.0039 0.0038
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0013 0.0039 0.0026
Schistosoma mansoni hypothetical protein 0.0031 0.0217 0.0205
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0211 0.1957 0.5528
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0099 0.0098
Echinococcus multilocularis lamin 0.0027 0.0174 0.0173
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0064 0.0532 0.052
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0038 0.0282 0.0281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0532 0.1287
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.006 0.0493 0.0664
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0013 0.0039 0.0038
Schistosoma mansoni elf1 0.0013 0.0039 0.0026
Brugia malayi cathepsin Z-like cysteine proteinase 0.0064 0.0532 0.0532
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0217 0.0216
Echinococcus multilocularis solute carrier family 5 0.0038 0.0282 0.0281
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0013 0.0013
Onchocerca volvulus Cathepsin L homolog 0.0064 0.0532 0.2669
Entamoeba histolytica cysteine protease, putative 0.0124 0.111 0.5438
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.004 0.0039
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0013 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0532 0.1287
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0493 0.1172
Loa Loa (eye worm) hypothetical protein 0.0099 0.0868 0.0867
Trypanosoma cruzi major cysteine proteinase, putative 0.0111 0.0985 0.0517
Echinococcus granulosus cathepsin L 0.0124 0.111 0.1109
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0013 0.0013
Giardia lamblia Cathepsin B precursor 0.0367 0.346 1
Echinococcus granulosus cathepsin L 0.0064 0.0532 0.0531
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.006 0.0493 0.0492
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0498 0.0486
Brugia malayi Papain family cysteine protease containing protein 0.0124 0.111 0.111
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0099 0.0098
Schistosoma mansoni survival motor neuron protein 0.0058 0.0478 0.0466
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0099 0.0099
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0013 0.0012
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0099 0.0087
Brugia malayi hypothetical protein 0.0286 0.2672 0.2672
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0098
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0217 0.0217
Giardia lamblia Cysteine protease 0.0064 0.0532 0.013
Loa Loa (eye worm) hypothetical protein 0.0075 0.0638 0.0637
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0104 0.0103
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0064 0.0532 0.0257
Giardia lamblia Cathepsin B precursor 0.0064 0.0532 0.013
Giardia lamblia Cysteine protease 0.0064 0.0532 0.013
Echinococcus multilocularis ETS transcription factor Elf 5 0.0013 0.0039 0.0038
Echinococcus granulosus lamin 0.0027 0.0174 0.0173
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0064 0.0532 0.0257
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0258 0.241 0.6461
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0064 0.0532 0.013
Giardia lamblia Cathepsin L-like protease 0.0064 0.0532 0.013
Echinococcus multilocularis cathepsin L cysteine protease 0.0211 0.1957 0.1956
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0064 0.0532 0.0531
Loa Loa (eye worm) fibroinase 0.0211 0.1957 0.1956
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.1379 0.3809
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.004 0.0039
Schistosoma mansoni cathepsin C 0.0064 0.0532 0.052
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0099 0.0087
Giardia lamblia Cysteine protease 0.0064 0.0532 0.013
Brugia malayi Ets-domain containing protein 0.0087 0.076 0.076
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0098
Entamoeba histolytica cysteine protease, putative 0.0124 0.111 0.5438
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0012
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0099 0.0099
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0217 0.0217
Loa Loa (eye worm) ets-domain-containing protein 0.0013 0.0039 0.0038
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0013 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0124 0.111 0.2078
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0064 0.0532 0.2328
Entamoeba histolytica cysteine proteinase, putative 0.0124 0.111 0.5438
Trypanosoma cruzi cysteine proteinase, putative 0.0124 0.111 0.0648
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0211 0.1957 0.5528
Brugia malayi cathepsin F-like cysteine proteinase 0.006 0.0494 0.0494
Echinococcus granulosus sodium:glucose cotransporter 0.0038 0.0282 0.0281
Schistosoma mansoni inositol transporter 0.0038 0.0282 0.027
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0013 0.0013
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0099 0.0098
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0013 0.0013
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0217 0.0216
Entamoeba histolytica cysteine proteinase, putative 0.0152 0.1379 0.689
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.019 0.0189
Entamoeba histolytica cysteine protease, putative 0.0064 0.0532 0.2328
Echinococcus multilocularis mitogen activated protein kinase 3 0.006 0.0493 0.0492
Giardia lamblia Cathepsin B precursor 0.0367 0.346 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0478 0.0478
Leishmania major cysteine peptidase A (CPA) 0.0211 0.1957 0.4935
Trypanosoma cruzi cysteine peptidase, putative 0.0258 0.241 0.2016
Trypanosoma cruzi cysteine peptidase, putative 0.0211 0.1957 0.154
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0064 0.0532 0.1287
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0064 0.0532 0.013
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0211 0.1957 0.5528
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0802 0.7656 0.7656
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0099 0.0087
Onchocerca volvulus 0.0149 0.1359 0.6922
Giardia lamblia Cysteine protease 0.0064 0.0532 0.013
Echinococcus multilocularis musashi 0.0027 0.0174 0.0173
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0013 0.0039 0.0038
Giardia lamblia Cathepsin L precursor 0.0064 0.0532 0.013
Onchocerca volvulus 0.0152 0.1379 0.7028
Loa Loa (eye worm) papain family cysteine protease containing protein 0.006 0.0494 0.0493
Brugia malayi cathepsin L-like cysteine proteinase 0.0064 0.0532 0.0532
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1045 1 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0494 0.0493
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0013 0.0013
Echinococcus granulosus cathepsin b 0.1045 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0064 0.0532 0.1287
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0098
Echinococcus granulosus cathepsin L cysteine protease 0.0124 0.111 0.1109
Entamoeba histolytica cysteine protease, putative 0.0064 0.0532 0.2328
Loa Loa (eye worm) hypothetical protein 0.006 0.0494 0.0493
Brugia malayi DNA-binding protein D-ETS-3 0.0013 0.0039 0.0039
Echinococcus granulosus high affinity choline transporter 1 0.0344 0.3234 0.3233
Entamoeba histolytica cysteine protease, putative 0.0064 0.0532 0.2328
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0367 0.346 0.3121
Loa Loa (eye worm) hypothetical protein 0.0152 0.1379 0.1378
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0013 0.0012
Plasmodium falciparum cysteine proteinase falcipain 3 0.0211 0.1957 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0258 0.241 0.6461
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0064 0.0532 0.013
Entamoeba histolytica cysteine protease, putative 0.0124 0.111 0.5438
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0258 0.241 0.6461
Entamoeba histolytica cysteine proteinase, putative 0.0211 0.1957 1
Plasmodium vivax vivapain-2 0.0211 0.1957 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0211 0.1957 0.1956
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0211 0.1957 0.5528
Onchocerca volvulus 0.0027 0.0174 0.0828
Onchocerca volvulus 0.0211 0.1957 1
Echinococcus multilocularis protein C ets 2 0.0013 0.0039 0.0038
Brugia malayi ecdysteroid receptor 0.001 0.0013 0.0013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0211 0.1957 0.5528
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0064 0.0532 0.052
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0038 0.0282 0.0281
Giardia lamblia Cathepsin B precursor 0.0064 0.0532 0.013
Schistosoma mansoni inositol transporter 0.0038 0.0282 0.027
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0013 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0064 0.0532 0.1287
Giardia lamblia Hypothetical protein 0.0064 0.0532 0.013
Loa Loa (eye worm) ctsf protein 0.0211 0.1957 0.1956
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0199 0.1832 0.1409
Echinococcus multilocularis cathepsin L 0.0064 0.0532 0.0531
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0099 0.0098
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0217 0.0216
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0532 0.1287
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0013 0.0012
Onchocerca volvulus Cathepsin L homolog 0.0211 0.1957 1
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0104 0.0092
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.2672 0.2671
Echinococcus granulosus dnaJ subfamily B 0.0405 0.382 0.382
Loa Loa (eye worm) hypothetical protein 0.0013 0.004 0.0039
Echinococcus granulosus cysteine protease 0.0124 0.111 0.1109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0211 0.1957 0.5528
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0064 0.0532 0.1287
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0532 0.1287
Entamoeba histolytica cysteine protease, putative 0.0064 0.0532 0.2328
Entamoeba histolytica cysteine protease, putative 0.0124 0.111 0.5438
Plasmodium vivax vivapain-1 0.0124 0.111 0.4207
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0493 0.1172
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0064 0.0532 0.1287
Entamoeba histolytica cysteine proteinase, putative 0.0124 0.111 0.5438
Loa Loa (eye worm) hypothetical protein 0.0064 0.0532 0.0531
Echinococcus multilocularis mitogen activated protein kinase 0.006 0.0493 0.0492
Trypanosoma cruzi cruzipain precursor, putative 0.006 0.0494 0.0001
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0064 0.0532 0.0257
Brugia malayi Papain family cysteine protease containing protein 0.0124 0.111 0.111
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0013 0.0013
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0104 0.0103
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1045 1 1
Echinococcus multilocularis cathepsin b 0.1045 1 1
Entamoeba histolytica hypothetical protein 0.0064 0.0532 0.2328
Schistosoma mansoni cathepsin F (C01 family) 0.0152 0.1379 0.1368
Schistosoma mansoni cpg binding protein 0.003 0.0206 0.0194
Entamoeba histolytica cysteine protease, putative 0.0211 0.1957 1
Echinococcus granulosus cathepsin l1 0.0152 0.1379 0.1378
Schistosoma mansoni cathepsin s 0.006 0.0494 0.0482
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0064 0.0532 0.052
Echinococcus multilocularis cysteine protease 0.0211 0.1957 0.1956
Trypanosoma cruzi cysteine peptidase, putative 0.006 0.0494 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0211 0.1957 0.5528
Echinococcus granulosus lamin dm0 0.0027 0.0174 0.0173
Echinococcus granulosus cathepsin b 0.1045 1 1
Schistosoma mansoni sodium/solute symporter 0.0038 0.0282 0.027
Brugia malayi cathepsin Z-like cysteine proteinase 0.0064 0.0532 0.0532
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0104 0.0092
Brugia malayi MAP kinase sur-1 0.006 0.0493 0.0493
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0344 0.3234 0.3233
Brugia malayi hypothetical protein 0.0149 0.1359 0.1359
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0258 0.241 0.6461
Brugia malayi PXA domain containing protein 0.0019 0.0099 0.0099
Schistosoma mansoni hypothetical protein 0.0031 0.0217 0.0205
Giardia lamblia Cathepsin B precursor 0.0064 0.0532 0.013
Schistosoma mansoni lamin 0.0027 0.0174 0.0161
Echinococcus granulosus cathepsin L cysteine proteinase 0.0211 0.1957 0.1956
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0013 0.0012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.0532 0.1287
Giardia lamblia Cathepsin L precursor 0.0064 0.0532 0.013
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0217 0.0216
Plasmodium vivax serine-repeat antigen (SERA) 0.0064 0.0532 0.0257
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0013 0.0012
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0099 0.0087
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0624 0.1075
Echinococcus multilocularis GPCR, family 2 0.0031 0.0217 0.0216
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0064 0.0532 0.052
Onchocerca volvulus Cathepsin L homolog 0.0211 0.1957 1
Echinococcus granulosus GPCR family 2 0.0031 0.0217 0.0216
Brugia malayi Cathepsin L-like precursor 0.0211 0.1957 0.1957
Entamoeba histolytica cysteine protease, putative 0.0124 0.111 0.5438
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0064 0.0532 0.2328
Plasmodium vivax unspecified product 0.0064 0.0532 0.0257
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0099 0.0098
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0013 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0367 0.346 1
Entamoeba histolytica cysteine protease, putative 0.0124 0.111 0.5438
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0064 0.0532 0.1287
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0124 0.111 0.3006
Echinococcus granulosus ewsr:fli fusion protein type 0.0013 0.0039 0.0038
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0064 0.0532 0.0531
Echinococcus granulosus mitogen activated protein kinase 0.006 0.0493 0.0492
Onchocerca volvulus 0.0064 0.0532 0.2669
Brugia malayi nuclear hormone receptor 0.001 0.0013 0.0013
Brugia malayi Fli-1 protein 0.0265 0.2479 0.2479
Echinococcus granulosus ETS transcription factor Elf 5 0.0013 0.0039 0.0038
Trypanosoma cruzi cysteine proteinase, putative 0.0124 0.111 0.0648
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0064 0.0532 0.1287
Toxoplasma gondii cathepsin CPC1 0.0064 0.0532 0.0785
Echinococcus multilocularis cysteine protease 0.0211 0.1957 0.1956
Loa Loa (eye worm) D-ets-2 protein 0.0013 0.0039 0.0038

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.005 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0631 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction: HTRF assay against cherry picks. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.0891 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.