Detailed information for compound 1401238

Basic information

Technical information
  • TDR Targets ID: 1401238
  • Name: 1-(3-methylphenyl)-3-(4-methylpyrimidin-2-yl) sulfanylpyrrolidine-2,5-dione
  • MW: 313.374 | Formula: C16H15N3O2S
  • H donors: 0 H acceptors: 4 LogP: 2.42 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(c1)N1C(=O)CC(C1=O)Sc1nccc(n1)C
  • InChi: 1S/C16H15N3O2S/c1-10-4-3-5-12(8-10)19-14(20)9-13(15(19)21)22-16-17-7-6-11(2)18-16/h3-8,13H,9H2,1-2H3
  • InChiKey: UZTZGPAVBURFRF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(3-methylphenyl)-3-(4-methylpyrimidin-2-yl)sulfanyl-pyrrolidine-2,5-dione
  • 1-(3-methylphenyl)-3-[(4-methyl-2-pyrimidinyl)thio]pyrrolidine-2,5-dione
  • 1-(3-methylphenyl)-3-[(4-methylpyrimidin-2-yl)thio]pyrrolidine-2,5-quinone
  • Oprea1_129166
  • IDI1_021832
  • 3-(4-Methyl-pyrimidin-2-ylsulfanyl)-1-m-tolyl-pyrrolidine-2,5-dione
  • BAS 04085484
  • STK087260
  • EU-0013385
  • ChemDiv3_003922

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus lamin 0.0026 0.0141 0.0339
Schistosoma mansoni retinoic acid receptor RXR 0.0027 0.0153 0.0368
Echinococcus multilocularis nardilysin 0.0014 0.0015 0.0037
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0032 0.0199 0.0778
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0049 0.0128
Schistosoma mansoni zinc finger protein 0.0015 0.0021 0.005
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0115 0.036
Brugia malayi hypothetical protein 0.0014 0.0016 0.0057
Onchocerca volvulus 0.0032 0.0199 0.0853
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.1836 0.6382
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0169 0.0732
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0029 0.0169 0.0937
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0049 0.0128
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0027 0.0153 0.0532
Loa Loa (eye worm) hypothetical protein 0.0027 0.0153 0.0532
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0079 0.0699 0.3341
Giardia lamblia NADH oxidase lateral transfer candidate 0.0029 0.0169 0.0022
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Echinococcus granulosus geminin 0.0164 0.1605 0.3869
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0018 0.0042
Onchocerca volvulus 0.0032 0.0199 0.0853
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0112 0.049
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0029 0.0169 0.0121
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.088 0.2122
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.4147 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0233 0.0561
Entamoeba histolytica protein kinase, putative 0.0069 0.0598 0.1764
Trypanosoma brucei glucose transporter, putative 0.007 0.0604 0.2875
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0141 0.049
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.287 1
Schistosoma mansoni hypothetical protein 0.008 0.0715 0.1723
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0032 0.0199 0.0778
Brugia malayi Cam kinase protein 1 0.0069 0.0598 0.2083
Onchocerca volvulus 0.0032 0.0199 0.0853
Leishmania major protein kinase, putative 0.0069 0.0598 0.2844
Loa Loa (eye worm) hypothetical protein 0.0032 0.0199 0.0695
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0027 0.0153 0.0532
Echinococcus multilocularis solute carrier family 22 0.0032 0.0199 0.0481
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0027 0.0153 0.0532
Loa Loa (eye worm) hypothetical protein 0.0032 0.0199 0.0695
Echinococcus granulosus solute carrier family 22 0.0032 0.0199 0.0481
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0027 0.0153 0.0368
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0233 0.0561
Giardia lamblia Sugar-proton symporter 0.0032 0.0199 0.0134
Trypanosoma brucei THT1 - hexose transporter, putative 0.007 0.0604 0.2875
Loa Loa (eye worm) hypothetical protein 0.0032 0.0199 0.0695
Leishmania major glucose transporter, lmgt3 0.007 0.0604 0.2875
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0027 0.0153 0.0532
Loa Loa (eye worm) hypothetical protein 0.0032 0.0199 0.0695
Schistosoma mansoni nardilysin (M16 family) 0.0024 0.0115 0.0276
Trichomonas vaginalis set domain proteins, putative 0.0229 0.2304 0.8021
Loa Loa (eye worm) hypothetical protein 0.0046 0.0352 0.1227
Toxoplasma gondii thioredoxin reductase 0.0083 0.0746 0.1107
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0163 0.0394
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0014 0.0016 0.0057
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.2009 0.7
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0224 0.2251 0.5428
Echinococcus multilocularis lamin 0.0026 0.0141 0.0339
Echinococcus granulosus insulin degrading enzyme 0.0024 0.0115 0.0276
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0112 0.049
Loa Loa (eye worm) hypothetical protein 0.0027 0.0153 0.0532
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0014 0.0016 0.0039
Loa Loa (eye worm) hypothetical protein 0.0032 0.0199 0.0695
Onchocerca volvulus 0.0032 0.0199 0.0853
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0049 0.0128
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0043 0.0316 0.1028
Loa Loa (eye worm) hypothetical protein 0.003 0.0178 0.0621
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.004 0.0294 0.0709
Toxoplasma gondii NADPH-glutathione reductase 0.0029 0.0169 0.0233
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.1836 0.6382
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0049 0.0128
Entamoeba histolytica hypothetical protein 0.005 0.0397 0.1033
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0027 0.0153 0.0532
Loa Loa (eye worm) hypothetical protein 0.008 0.0715 0.249
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0115 0.0466
Schistosoma mansoni hypothetical protein 0.0028 0.0163 0.0394
Trypanosoma brucei glucose transporter, putative 0.007 0.0604 0.2875
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.1836 0.6382
Echinococcus granulosus dnaJ subfamily B 0.0403 0.4147 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.059 0.2057
Loa Loa (eye worm) hypothetical protein 0.0027 0.0153 0.0532
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0224 0.2251 0.5428
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Onchocerca volvulus 0.004 0.0294 0.1259
Onchocerca volvulus Glucosylceramidase homolog 0.0185 0.1836 0.7857
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0084 0.0294
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0018 0.0061
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0513 0.1237
Brugia malayi Steroid receptor seven-up type 2 0.0027 0.0153 0.0532
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0153 0.0368
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Schistosoma mansoni nardilysin (M16 family) 0.0024 0.0115 0.0276
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0283 0.287 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0069 0.0598 0.0552
Brugia malayi Bromodomain containing protein 0.003 0.0188 0.0653
Trypanosoma cruzi hexose transporter, putative 0.007 0.0604 0.2875
Onchocerca volvulus 0.0032 0.0199 0.0853
Loa Loa (eye worm) hypothetical protein 0.0032 0.0199 0.0695
Echinococcus granulosus chromobox protein 1 0.0067 0.058 0.1397
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0067 0.058 0.1699
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0171
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.0169 0.0408
Plasmodium vivax proline--tRNA ligase, putative 0.0079 0.0699 0.0653
Plasmodium falciparum thioredoxin reductase 0.0029 0.0169 0.0121
Schistosoma mansoni lysyl-tRNA synthetase 0.005 0.0397 0.0956
Chlamydia trachomatis lysine--tRNA ligase 0.005 0.0397 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0029 0.0169 0.3458
Schistosoma mansoni kinase 0.0051 0.0403 0.0971
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0032 0.0199 0.088
Schistosoma mansoni insulysin unit 3 (M16 family) 0.0024 0.0115 0.0276
Onchocerca volvulus 0.0032 0.0199 0.0853
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0029 0.0169 0.0732
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.008 0.0715 0.1723
Chlamydia trachomatis insulinase family protease III 0.0024 0.0115 0.1882
Plasmodium falciparum protein kinase 7 0.0635 0.6612 0.6596
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0163 0.0224
Trypanosoma cruzi hexose transporter 0.007 0.0604 0.2875
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0032 0.0199 0.0151
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.287 1
Schistosoma mansoni cpg binding protein 0.0032 0.0201 0.0485
Trichomonas vaginalis chromobox protein, putative 0.0067 0.058 0.1985
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0263 0.0634
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.2867 0.999
Echinococcus granulosus intermediate filament protein 0.0026 0.0141 0.0339
Plasmodium falciparum calcium-dependent protein kinase 5 0.0069 0.0598 0.0552
Schistosoma mansoni zinc finger protein 0.0021 0.0082 0.0198
Trypanosoma brucei glucose transporter, putative 0.007 0.0604 0.2875
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0067 0.058 0.2021
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0177 0.0427
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0189 0.1876 0.8871
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0141 0.049
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0069 0.0598 0.2083
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0069 0.0598 0.1442
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0079 0.0699 0.1036
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0115 0.0278
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Echinococcus granulosus nardilysin 0.0024 0.0115 0.0276
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0224 0.2251 0.5428
Trypanosoma brucei glucose transporter 2A 0.007 0.0604 0.2875
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0017 0.0017
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0079 0.0699 0.3341
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0029 0.0169 0.0732
Echinococcus granulosus solute carrier family 22 0.0032 0.0199 0.0481
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0067 0.058 0.1398
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0032 0.0199 0.1172
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0112 0.049
Echinococcus granulosus chromobox protein 1 0.0067 0.058 0.1397
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0057
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0112 0.039
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0043 0.0316 0.1345
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0069 0.0598 0.2083
Loa Loa (eye worm) insulin-degrading enzyme 0.0024 0.0115 0.0399
Trypanosoma brucei THT1 - hexose transporter, putative 0.007 0.0604 0.2875
Loa Loa (eye worm) hypothetical protein 0.0032 0.0199 0.0695
Schistosoma mansoni intermediate filament proteins 0.0026 0.0141 0.0339
Echinococcus granulosus peregrin 0.003 0.0188 0.0452
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0021 0.0088 0.0307
Giardia lamblia Kinase, PLK 0.0096 0.088 0.2651
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0067 0.058 0.2021
Brugia malayi CHD4 protein 0.0014 0.0018 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0265 0.0884
Schistosoma mansoni protein kinase 0.0069 0.0598 0.1442
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0153 0.0532
Echinococcus multilocularis lamin dm0 0.0026 0.0141 0.0339
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.1331 0.613
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0027 0.0153 0.0368
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.088 0.2122
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0199 0.0654
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.1942 0.6754
Loa Loa (eye worm) hypothetical protein 0.0027 0.0153 0.0532
Schistosoma mansoni sugar transporter 0.0032 0.0199 0.0481
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0199 0.088
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.005 0.0397 0.1852
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0079 0.0699 0.3341
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.287 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Toxoplasma gondii sugar transporter ST2 0.0032 0.0199 0.0279
Leishmania major glucose transporter/membrane transporter D2, putative 0.007 0.0604 0.2875
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0148 0.0474
Echinococcus granulosus methyl CpG binding domain protein 2 0.0016 0.0039 0.0094
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0263 0.0634
Plasmodium falciparum glutathione reductase 0.0083 0.0746 0.07
Giardia lamblia Prolyl-tRNA synthetase 0.0067 0.058 0.1541
Brugia malayi PHD-finger family protein 0.0026 0.0137 0.0477
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.287 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0189 0.1876 0.8911
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0057
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0153 0.0532
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0069 0.0598 0.0883
Brugia malayi Sugar transporter family protein 0.0032 0.0199 0.0695
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0029 0.0169 0.0937
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Treponema pallidum NADH oxidase 0.0029 0.0169 0.0191
Onchocerca volvulus 0.0032 0.0199 0.0853
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.2867 1
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.287 1
Mycobacterium tuberculosis Probable reductase 0.0189 0.1876 0.8911
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0224 0.2251 0.5428
Trichomonas vaginalis myo-inositol transporter, putative 0.0032 0.0199 0.0654
Onchocerca volvulus 0.003 0.0178 0.0763
Schistosoma mansoni protein kinase 0.0069 0.0598 0.1442
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.039 0.1321
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0112 0.0271
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0163 0.0569
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0295 0.099
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0014 0.0016 0.0039
Schistosoma mansoni chromobox protein 0.0067 0.058 0.1397
Loa Loa (eye worm) sugar transporter 0.0032 0.0199 0.0695
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0224 0.2251 0.5428
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0029 0.0169 0.0732
Echinococcus granulosus ecdysone induced protein 78C 0.0027 0.0153 0.0368
Plasmodium falciparum lysine--tRNA ligase 0.005 0.0397 0.0349
Giardia lamblia Hexose transporter 0.0032 0.0199 0.0134
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0283 0.287 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0032 0.0199 0.0695
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0027 0.0153 0.0368
Echinococcus multilocularis nardilysin 0.0024 0.0115 0.0276
Brugia malayi Major Facilitator Superfamily protein 0.0032 0.0199 0.0695
Leishmania major myo-inositol/proton symporter (MIT) 0.0032 0.0199 0.088
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0032 0.0199 0.0481
Trypanosoma brucei polo-like protein kinase 0.0096 0.088 0.4234
Echinococcus multilocularis cpg binding protein 0.0032 0.0201 0.0485
Schistosoma mansoni RAR-like nuclear receptor 0.0027 0.0153 0.0368
Echinococcus multilocularis chromobox protein 1 0.0067 0.058 0.1397
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0263 0.0917
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0069 0.0598 0.0552
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0164 0.0573
Schistosoma mansoni steroid hormone receptor ad4bp 0.0027 0.0153 0.0368
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.088 0.3036
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.1836 0.6382
Onchocerca volvulus 0.0027 0.0153 0.0654
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.088 0.3036
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0112 0.0271
Mycobacterium ulcerans hypothetical protein 0.0024 0.0115 0.0517
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.088 0.4234
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0027 0.0153 0.0532
Toxoplasma gondii lysine-tRNA ligase 0.005 0.0397 0.0578
Trypanosoma brucei glucose transporter, putative 0.007 0.0604 0.2875
Toxoplasma gondii transporter, major facilitator family protein 0.0032 0.0199 0.0279
Echinococcus multilocularis insulin degrading enzyme 0.0024 0.0115 0.0276
Loa Loa (eye worm) hypothetical protein 0.0039 0.0282 0.0983
Plasmodium vivax glutathione reductase, putative 0.0083 0.0746 0.07
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0092 0.0845 0.2037
Loa Loa (eye worm) steroid hormone receptor 0.0027 0.0153 0.0532
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0199 0.0654
Echinococcus multilocularis solute carrier family 22 0.0032 0.0199 0.0481
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0115 0.0517
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.2867 0.999
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0265 0.1134
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.2867 0.999
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0045 0.0157
Loa Loa (eye worm) hypothetical protein 0.0027 0.0153 0.0532
Schistosoma mansoni glucose transport protein 0.0224 0.2251 0.5428
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.021 0.21 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Trypanosoma brucei trypanothione reductase 0.0083 0.0746 0.3573
Trichomonas vaginalis CAMK family protein kinase 0.0069 0.0598 0.2049
Plasmodium vivax calcium-dependent protein kinase, putative 0.0069 0.0598 0.0552
Trypanosoma brucei glucose transporter 1E 0.007 0.0604 0.2875
Schistosoma mansoni hypothetical protein 0.008 0.0715 0.1723
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0169 0.0732
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0169 0.0732
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.008 0.0715 0.1723
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.005 0.0397 0.1432
Plasmodium vivax lysine--tRNA ligase, putative 0.005 0.0397 0.0349
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0141 0.049
Mycobacterium ulcerans hypothetical protein 0.0023 0.0112 0.049
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0153 0.0368
Toxoplasma gondii sporozoite developmental protein 0.0024 0.0115 0.015
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0263 0.0634
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0069 0.0598 0.2083
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Schistosoma mansoni cpg binding protein 0.0032 0.0201 0.0485
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0029 0.0169 0.0632
Loa Loa (eye worm) hypothetical protein 0.0027 0.0153 0.0532
Brugia malayi CXXC zinc finger family protein 0.0028 0.0164 0.0573
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0067 0.058 0.2354
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.039 0.1321
Onchocerca volvulus 0.0032 0.0199 0.0853
Brugia malayi chromobox protein homolog 3 0.0038 0.0265 0.0923
Loa Loa (eye worm) hypothetical protein 0.0023 0.0112 0.039
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.0352 0.0849
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0069 0.0598 0.1442
Brugia malayi Pre-SET motif family protein 0.0202 0.2009 0.7
Plasmodium falciparum calcium-dependent protein kinase 1 0.0069 0.0598 0.0552
Leishmania major trypanothione reductase 0.0083 0.0746 0.3573
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0027 0.0153 0.0532
Echinococcus multilocularis synaptic vesicle 2 protein 0.0032 0.0199 0.0481
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.0169 0.0408
Brugia malayi intermediate filament protein 0.0026 0.0141 0.049
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0295 0.1264
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0016 0.0057
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0028 0.0158 0.0549
Onchocerca volvulus 0.0146 0.1416 0.6061
Brugia malayi hypothetical protein 0.0014 0.0016 0.0057
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0153 0.0368
Echinococcus multilocularis calcium dependent protein kinase 0.0064 0.0549 0.1325
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0027 0.0153 0.0532
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0153 0.0368
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0027 0.0153 0.0532
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.088 0.3036
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0226 0.0546
Brugia malayi Heterochromatin protein 1 0.0067 0.058 0.2019
Brugia malayi Bromodomain containing protein 0.0074 0.0651 0.227
Trichomonas vaginalis glucose transporter, putative 0.007 0.0604 0.2071
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0169 0.0732
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0199 0.0654
Plasmodium falciparum calcium-dependent protein kinase 2 0.0069 0.0598 0.0552
Loa Loa (eye worm) hypothetical protein 0.0027 0.0153 0.0532
Trypanosoma cruzi sugar transporter, putative 0.0032 0.0199 0.088
Onchocerca volvulus 0.0026 0.0141 0.0602
Onchocerca volvulus 0.0026 0.0141 0.0602
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0017 0.0017
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0153 0.0368
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0199 0.0654
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0163 0.0115
Schistosoma mansoni glucose transporter 0.0032 0.0199 0.0481
Onchocerca volvulus 0.0032 0.0199 0.0853
Echinococcus granulosus solute carrier family 22 0.0032 0.0199 0.0481
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0224 0.2251 0.5428
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.008 0.0715 0.1723
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.088 0.3036
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0153 0.0368
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Echinococcus granulosus solute carrier family 22 0.0032 0.0199 0.0481
Schistosoma mansoni apoptosis regulator bax 0.008 0.0715 0.1723
Loa Loa (eye worm) glutathione reductase 0.0083 0.0746 0.2598
Brugia malayi hypothetical protein 0.0032 0.0199 0.0695
Echinococcus multilocularis nardilysin 0.0024 0.0115 0.0276
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.088 0.3066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0027 0.0153 0.0532
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0092 0.0845 0.2037
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0079 0.0699 0.3341
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0014 0.0016 0.0039
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0027 0.0153 0.0368
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0115 0.0517
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0112 0.049
Schistosoma mansoni cpg binding protein 0.0028 0.0164 0.0396
Brugia malayi nuclear receptor RXR 0.0014 0.0016 0.0057
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0153 0.0368
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0049 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0199 0.0654
Trypanosoma brucei glucose transporter, putative 0.007 0.0604 0.2875
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0044 0.0331 0.1115
Loa Loa (eye worm) hypothetical protein 0.0023 0.0112 0.039
Brugia malayi PHD-finger family protein 0.0028 0.0163 0.0569
Mycobacterium ulcerans hypothetical protein 0.0024 0.0115 0.0517
Brugia malayi ecdysteroid receptor 0.0027 0.0153 0.0532
Echinococcus multilocularis ecdysone induced protein 78C 0.0027 0.0153 0.0368
Brugia malayi Sugar transporter family protein 0.0224 0.2251 0.7845
Brugia malayi nuclear hormone receptor 0.0027 0.0153 0.0532
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0169 0.0732
Plasmodium falciparum calcium-dependent protein kinase 4 0.0069 0.0598 0.0552
Echinococcus multilocularis lysyl tRNA synthetase 0.005 0.0397 0.0956
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0012 0.0042
Toxoplasma gondii sugar transporter ST1 0.0032 0.0199 0.0279
Schistosoma mansoni hypothetical protein 0.0403 0.4147 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0039 0.0094
Schistosoma mansoni hypothetical protein 0.002 0.0076 0.0182
Brugia malayi Pax transcription factor protein 2 0.0233 0.2337 0.8142
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0189 0.1876 0.8911
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.0352 0.0849
Treponema pallidum fructose-bisphosphate aldolase 0.0282 0.2867 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0027 0.0153 0.0532
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0027 0.0153 0.0368
Onchocerca volvulus 0.0032 0.0199 0.0853
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0604 0.2071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0027 0.0153 0.0532
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0069 0.0598 0.0552
Trichomonas vaginalis sugar transporter, putative 0.007 0.0604 0.2071
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0112 0.0354
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0169 0.0732
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Trypanosoma cruzi trypanothione reductase, putative 0.0083 0.0746 0.3573
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0153 0.0532
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0115 0.0466
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.2867 0.999
Plasmodium falciparum proline--tRNA ligase 0.0079 0.0699 0.0653
Schistosoma mansoni chromobox protein 0.0067 0.058 0.1397
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Echinococcus multilocularis chromobox protein 1 0.0067 0.058 0.1397
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0027 0.0153 0.0368
Echinococcus multilocularis solute carrier family 22 0.0032 0.0199 0.0481
Mycobacterium tuberculosis Conserved protein 0.0024 0.0115 0.037
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.088 0.3036
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0281 0.0676
Loa Loa (eye worm) hypothetical protein 0.0027 0.0153 0.0532
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.008 0.0715 0.1723
Loa Loa (eye worm) hypothetical protein 0.0032 0.0199 0.0695
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Schistosoma mansoni glucose transport protein 0.0224 0.2251 0.5428
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0169 0.0732
Schistosoma mansoni hypothetical protein 0.008 0.0715 0.1723
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0268 0.122
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0153 0.0532
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.2867 0.999
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0295 0.099
Schistosoma mansoni jumonji domain containing protein 0.0073 0.0643 0.1551
Brugia malayi hypothetical protein 0.0032 0.0199 0.0695
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0112 0.0449
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0029 0.0169 0.0121
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.0169 0.059
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0115 0.0517
Echinococcus granulosus 3'partial|nardilysin 0.0024 0.0115 0.0276
Loa Loa (eye worm) hypothetical protein 0.0067 0.058 0.2021
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0027 0.0153 0.0532
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0115 0.037
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Loa Loa (eye worm) hypothetical protein 0.0146 0.1416 0.4935
Schistosoma mansoni hypothetical protein 0.0224 0.2251 0.5428
Trypanosoma brucei hypothetical protein, conserved 0.0206 0.205 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Brugia malayi lysyl-tRNA synthetase 0.005 0.0397 0.1382
Trypanosoma cruzi glucose transporter, putative 0.0032 0.0199 0.088
Brugia malayi nuclear receptor NHR-88 0.0027 0.0153 0.0532
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0115 0.0466
Schistosoma mansoni hypothetical protein 0.0164 0.1605 0.3869
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.088 0.3066
Brugia malayi hypothetical protein 0.0032 0.0199 0.0695
Onchocerca volvulus 0.0032 0.0199 0.0853
Trichomonas vaginalis glucose transporter, putative 0.007 0.0604 0.2071
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0027 0.0153 0.0654
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0018 0.0042
Trichomonas vaginalis sugar transport protein, putative 0.0032 0.0199 0.0654
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0069 0.0598 0.2844
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0604 0.2071
Schistosoma mansoni insulysin unit 3 (M16 family) 0.0024 0.0115 0.0276
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0199 0.0654
Loa Loa (eye worm) hypothetical protein 0.0032 0.0199 0.0695
Schistosoma mansoni sugar transporter 0.0032 0.0199 0.0481
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0018 0.0042
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0067 0.058 0.1398
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0363 0.3725 0.3694
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0027 0.0153 0.0368
Loa Loa (eye worm) hypothetical protein 0.0032 0.0199 0.0695
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0029 0.0169 0.0233
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0352 0.0849
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0069 0.0598 0.0883
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0049 0.0128
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.287 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0032 0.0199 0.0695
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0027 0.0153 0.0368
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0177 0.0427
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.088 0.2122
Loa Loa (eye worm) major facilitator superfamily transporter 0.0032 0.0199 0.0695
Trichomonas vaginalis mercuric reductase, putative 0.0029 0.0169 0.0549
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0112 0.049
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0027 0.0153 0.0368
Loa Loa (eye worm) hypothetical protein 0.0067 0.058 0.2021
Loa Loa (eye worm) pax transcription factor protein 2 0.0233 0.2337 0.8142
Plasmodium falciparum calcium-dependent protein kinase 3 0.0069 0.0598 0.0552
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0482 0.168
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0049 0.0128
Loa Loa (eye worm) hypothetical protein 0.0028 0.0163 0.0569
Trypanosoma cruzi hypothetical protein, conserved 0.0206 0.205 1
Trypanosoma brucei sugar transporter, putative 0.0032 0.0199 0.088
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0014 0.0016 0.0039
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0177 0.0245
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0112 0.039
Brugia malayi glutathione reductase 0.0083 0.0746 0.2598
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0049 0.0128
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.1331 1
Brugia malayi Bromodomain containing protein 0.0037 0.0257 0.0896
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Onchocerca volvulus Protein ultraspiracle homolog 0.0027 0.0153 0.0654
Schistosoma mansoni protein kinase 0.0069 0.0598 0.1442
Toxoplasma gondii sugar transporter ST3 0.0032 0.0199 0.0279
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0027 0.0153 0.0368
Brugia malayi Major Facilitator Superfamily protein 0.0032 0.0199 0.0695
Plasmodium vivax sugar transporter, putative 0.0032 0.0199 0.0151
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0083 0.0746 0.3428
Onchocerca volvulus Bile acid receptor homolog 0.0027 0.0153 0.0654
Brugia malayi jmjC domain containing protein 0.0038 0.0263 0.0917
Leishmania major hypothetical protein, conserved 0.0206 0.205 1
Plasmodium vivax hexose transporter 0.0224 0.2251 0.2213
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0265 0.0884
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0112 0.0271
Loa Loa (eye worm) hypothetical protein 0.0032 0.0199 0.0695
Loa Loa (eye worm) hypothetical protein 0.0032 0.0199 0.0695
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0029 0.0169 0.0121
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0112 0.049
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Echinococcus multilocularis thioredoxin glutathione reductase 0.0083 0.0751 0.1811
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0069 0.0598 0.1442
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0021 0.0088 0.0307
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0069 0.0598 0.1442
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.088 0.4234
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0281 0.0676
Loa Loa (eye worm) hypothetical protein 0.0026 0.0141 0.049
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.2867 0.999
Loa Loa (eye worm) hypothetical protein 0.0055 0.0446 0.1553
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0169 0.0732
Echinococcus multilocularis geminin 0.0164 0.1605 0.3869
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.008 0.0715 0.1723
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.2867 1
Trypanosoma cruzi peptidase, putative 0.0024 0.0115 0.0462
Echinococcus multilocularis zinc finger protein 0.0021 0.0082 0.0198
Trypanosoma cruzi peptidase, putative 0.0024 0.0115 0.0462
Onchocerca volvulus 0.0028 0.0164 0.0704
Schistosoma mansoni sugar transporter 0.0032 0.0199 0.0481
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0048 0.0115
Echinococcus multilocularis musashi 0.0026 0.0141 0.0339
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.1331 0.6267
Brugia malayi jmjC domain containing protein 0.0092 0.0845 0.2944
Echinococcus granulosus synaptic vesicle 2 protein 0.0032 0.0199 0.0481
Trichomonas vaginalis sugar transporter, putative 0.007 0.0604 0.2071
Plasmodium falciparum glutathione reductase 0.0029 0.0169 0.0121
Echinococcus multilocularis thyroid hormone receptor alpha 0.0027 0.0153 0.0368
Brugia malayi Major Facilitator Superfamily protein 0.0032 0.0199 0.0695
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0148 0.0474
Schistosoma mansoni insulysin (M16 family) 0.0013 0.0003 0.0008
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0069 0.0598 0.1442
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0067 0.058 0.1986
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0189 0.1876 0.8911
Onchocerca volvulus Alhambra homolog 0.0028 0.0163 0.0698
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.008 0.0715 0.249
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0027 0.0153 0.0532
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0067 0.058 0.1398
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0027 0.0153 0.0368
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.1836 0.6382
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0057
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0494 0.1192
Leishmania major glucose transporter, lmgt2 0.007 0.0604 0.2875
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.1836 0.6382
Echinococcus granulosus cpg binding protein 0.0032 0.0201 0.0485
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0153 0.0532
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0169 0.0732
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0069 0.0598 0.0883
Brugia malayi Pre-SET motif family protein 0.0029 0.0177 0.0617
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0224 0.2251 0.5428
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.021 0.21 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0224 0.2251 0.5428
Toxoplasma gondii protein kinase, putative 0.0635 0.6612 1
Plasmodium falciparum mitogen-activated protein kinase 2 0.0363 0.3725 0.3694
Loa Loa (eye worm) hypothetical protein 0.0032 0.0199 0.0695
Giardia lamblia Lysyl-tRNA synthetase 0.005 0.0397 0.0863
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0057
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0069 0.0598 0.1442
Loa Loa (eye worm) sugar transporter 0.0224 0.2251 0.7845
Schistosoma mansoni lysyl-tRNA synthetase 0.005 0.0397 0.0956
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0032 0.0199 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0163 0.0224
Echinococcus granulosus FTZ F1 alpha 0.0027 0.0153 0.0368
Echinococcus granulosus zinc finger protein 0.0021 0.0082 0.0198
Loa Loa (eye worm) apoptosis regulator protein 0.008 0.0715 0.249
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0171
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0115 0.0278
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0016 0.0039 0.0094
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.0169 0.0408
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.088 0.3766
Echinococcus multilocularis General substrate transporter 0.0193 0.1915 0.4619
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.2867 0.999
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0189 0.1876 0.8911
Onchocerca volvulus 0.0032 0.0199 0.0853
Brugia malayi major facilitator superfamily protein 0.0032 0.0199 0.0695
Brugia malayi hypothetical protein 0.0146 0.1416 0.4935
Echinococcus granulosus lamin dm0 0.0026 0.0141 0.0339
Onchocerca volvulus 0.0229 0.2304 0.9861
Schistosoma mansoni bromodomain containing protein 0.0063 0.0531 0.128
Leishmania major hypothetical protein, conserved 0.0032 0.0199 0.088
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0079 0.0699 0.3341
Echinococcus multilocularis peregrin 0.003 0.0188 0.0452
Onchocerca volvulus 0.0233 0.2337 1
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.1942 0.6754
Schistosoma mansoni lamin 0.0026 0.0141 0.0339
Plasmodium vivax thioredoxin reductase, putative 0.0083 0.0746 0.07
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0169 0.0732
Onchocerca volvulus 0.0032 0.0199 0.0853
Trichomonas vaginalis glutathione reductase, putative 0.0029 0.0169 0.0549
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.088 0.2788
Echinococcus multilocularis solute carrier family 22 0.0032 0.0199 0.0481
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0112 0.0354
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0039 0.0094
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0112 0.049
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.088 0.3036
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0153 0.0532
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0112 0.0449
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0032 0.0199 0.0481
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0163 0.0394
Mycobacterium ulcerans sugar transporter 0.0032 0.0199 0.1172
Plasmodium falciparum hexose transporter 0.0224 0.2251 0.2213
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0363 0.3725 0.5623
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0112 0.0449
Schistosoma mansoni thyroid hormone receptor 0.0027 0.0153 0.0368
Leishmania major lysyl-tRNA synthetase, putative 0.005 0.0397 0.1852
Leishmania major phosphoglycan beta 1,3 galactosyltransferase 5 0.0024 0.0115 0.0462
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0171
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0076 0.0264
Schistosoma mansoni sugar transporter 0.0032 0.0199 0.0481
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0469 0.0688
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0171
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.0598 0.1442
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.0352 0.0849
Brugia malayi insulin-degrading enzyme 0.0024 0.0115 0.0399
Brugia malayi steroid hormone receptor 0.0027 0.0153 0.0532
Loa Loa (eye worm) hypothetical protein 0.0037 0.0258 0.0899
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0032 0.0199 0.1172
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Brugia malayi Thioredoxin reductase 0.0083 0.0746 0.2598
Toxoplasma gondii facilitative glucose transporter GT1 0.0224 0.2251 0.3389
Trypanosoma cruzi hexose transporter, putative 0.007 0.0604 0.2875
Onchocerca volvulus Putative transporter 0.0032 0.0199 0.0853
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.2867 0.999
Loa Loa (eye worm) hypothetical protein 0.0032 0.0199 0.0695
Onchocerca volvulus 0.0023 0.0112 0.0479
Mycobacterium tuberculosis Probable oxidoreductase 0.021 0.21 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0029 0.0169 0.0732
Trichomonas vaginalis chromobox protein, putative 0.0067 0.058 0.1985
Schistosoma mansoni hypothetical protein 0.0164 0.1605 0.3869
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.005 0.0397 0.1344
Trypanosoma brucei glucose transporter, putative 0.007 0.0604 0.2875
Trypanosoma brucei glucose transporter, putative 0.007 0.0604 0.2875
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Loa Loa (eye worm) hypothetical protein 0.0023 0.0112 0.039
Trichomonas vaginalis sugar transporter, putative 0.007 0.0604 0.2071
Loa Loa (eye worm) hypothetical protein 0.0043 0.0319 0.1112
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0169 0.0732
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0027 0.0153 0.0368
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0153 0.0532
Echinococcus granulosus lysyl tRNA synthetase 0.005 0.0397 0.0956
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.021 0.21 1
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0012 0.0042
Schistosoma mansoni hypothetical protein 0.0015 0.0021 0.005
Trypanosoma cruzi hypothetical protein, conserved 0.0206 0.205 1
Echinococcus granulosus calcium dependent protein kinase 0.0064 0.0549 0.1325
Trypanosoma brucei glucose transporter, putative 0.007 0.0604 0.2875
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.0169 0.0732
Plasmodium falciparum phd finger protein, putative 0.0028 0.0163 0.0115
Loa Loa (eye worm) hypothetical protein 0.0017 0.0049 0.0171
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0043 0.0316 0.1345
Trichomonas vaginalis conserved hypothetical protein 0.0224 0.2251 0.7835
Loa Loa (eye worm) hypothetical protein 0.0026 0.0136 0.0473
Plasmodium falciparum thioredoxin reductase 0.0083 0.0746 0.07
Schistosoma mansoni coup transcription factor 0.0027 0.0153 0.0368
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0029 0.0169 0.0937
Brugia malayi major facilitator superfamily protein 0.0032 0.0199 0.0695
Loa Loa (eye worm) thioredoxin reductase 0.0083 0.0746 0.2598
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0016 0.0057
Echinococcus granulosus thioredoxin glutathione reductase 0.0083 0.0751 0.1811
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0189 0.1876 0.8911
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0069 0.0598 0.1442
Schistosoma mansoni glucose transport protein 0.0224 0.2251 0.5428
Mycobacterium ulcerans lysyl-tRNA synthetase 0.005 0.0397 0.2711
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0494 0.1192
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.1836 0.6382
Giardia lamblia Fructose-bisphosphate aldolase 0.0282 0.2867 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0029 0.0169 0.0121
Leishmania major glucose transporter, lmgt1 0.007 0.0604 0.2875
Loa Loa (eye worm) hypothetical protein 0.0014 0.0016 0.0057
Schistosoma mansoni lamin 0.0026 0.0141 0.0339
Onchocerca volvulus 0.0032 0.0199 0.0853
Echinococcus granulosus Sugar transporter ERD6 protein 0.0032 0.0199 0.0481
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0163 0.0394
Entamoeba histolytica protein kinase, putative 0.0069 0.0598 0.1764
Plasmodium vivax SET domain protein, putative 0.0029 0.0177 0.0128
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0069 0.0598 0.1442
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0067 0.058 0.1398
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0027 0.0153 0.0368
Chlamydia trachomatis proline--tRNA ligase 0.0024 0.0117 0.1943
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0027 0.0153 0.0532
Loa Loa (eye worm) hypothetical protein 0.0048 0.0377 0.1314
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.088 0.4234
Trypanosoma brucei THT1 - hexose transporter, putative 0.007 0.0604 0.2875
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Echinococcus granulosus General substrate transporter 0.0193 0.1915 0.4619
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.1382
Trypanosoma cruzi hexose transporter, putative 0.007 0.0604 0.2875
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.005 0.0397 0.1852
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0199 0.0654
Onchocerca volvulus 0.0032 0.0199 0.0853
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0024 0.0117 0.0527
Onchocerca volvulus 0.0032 0.0199 0.0853
Toxoplasma gondii rhoptry metalloprotease toxolysin TLN1 0.0024 0.0115 0.015
Loa Loa (eye worm) heterochromatin protein 1 0.0067 0.058 0.2019
Mycobacterium ulcerans lysyl-tRNA synthetase 0.005 0.0397 0.2711
Toxoplasma gondii insulysin, putative 0.0022 0.0102 0.0131
Trypanosoma brucei peptidase, putative 0.0024 0.0115 0.0462
Echinococcus multilocularis FTZ F1 alpha 0.0027 0.0153 0.0368
Mycobacterium ulcerans integral membrane transport protein 0.0032 0.0199 0.1172
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0027 0.0153 0.0368
Loa Loa (eye worm) hypothetical protein 0.0069 0.0598 0.2083
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0169 0.0732
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.088 0.3036
Loa Loa (eye worm) hypothetical protein 0.0038 0.0265 0.0923
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0112 0.039
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0159 0.0384
Brugia malayi Sugar transporter family protein 0.0032 0.0199 0.0695

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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