Detailed information for compound 1402522

Basic information

Technical information
  • TDR Targets ID: 1402522
  • Name: ethyl 3-[(3-methoxyphenyl)methyl]-1-(3-pyridi n-3-ylpropanoyl)piperidine-3-carboxylate
  • MW: 410.506 | Formula: C24H30N2O4
  • H donors: 0 H acceptors: 3 LogP: 3.01 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C1(CCCN(C1)C(=O)CCc1cccnc1)Cc1cccc(c1)OC
  • InChi: 1S/C24H30N2O4/c1-3-30-23(28)24(16-20-7-4-9-21(15-20)29-2)12-6-14-26(18-24)22(27)11-10-19-8-5-13-25-17-19/h4-5,7-9,13,15,17H,3,6,10-12,14,16,18H2,1-2H3
  • InChiKey: BIZCZSIKHWVQOU-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • ethyl 3-[(3-methoxyphenyl)methyl]-1-[3-(3-pyridyl)propanoyl]piperidine-3-carboxylate
  • 3-[(3-methoxyphenyl)methyl]-1-[1-oxo-3-(3-pyridyl)propyl]-3-piperidinecarboxylic acid ethyl ester
  • 3-(3-methoxybenzyl)-1-[3-(3-pyridyl)propanoyl]nipecotic acid ethyl ester
  • ethyl 3-(3-methoxybenzyl)-1-(3-pyridin-3-ylpropanoyl)piperidine-3-carboxylate
  • MLS000733331
  • SMR000319084

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0977 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0211 0.0211
Echinococcus multilocularis protein dispatched 1 0.0047 0.0109 0.0109
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0101 0.0338
Schistosoma mansoni hypothetical protein 0.0039 0.0078 0.0255
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0008 0.0008
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0008 0.0029
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0977 1
Brugia malayi jmjC domain containing protein 0.0071 0.0211 0.2008
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0065 0.0236
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0213 0.0213
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0107 0.0363 0.0464
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0253 0.0977 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0213 0.1693
Brugia malayi hypothetical protein 0.012 0.0417 0.4159
Loa Loa (eye worm) hypothetical protein 0.005 0.0123 0.0717
Schistosoma mansoni hypothetical protein 0.0205 0.0772 0.2782
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0611 0.5899
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0047 0.0111 0.0973
Loa Loa (eye worm) hypothetical protein 0.0095 0.0313 0.2784
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0084 0.0084
Echinococcus multilocularis microtubule associated protein 2 0.0676 0.2755 0.2755
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0611 0.5899
Brugia malayi AMP-binding enzyme family protein 0.0047 0.011 0.0954
Mycobacterium ulcerans transcriptional regulator 0.1556 0.6448 1
Echinococcus granulosus microtubule associated protein 2 0.0676 0.2755 1
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0441 0.1576
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0124 0.0729
Brugia malayi AMP-binding enzyme family protein 0.0047 0.011 0.0954
Leishmania major mitochondrial DNA polymerase beta 0.0594 0.241 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0075 0.0198
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0084 0.0306
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0133 0.0456
Trypanosoma cruzi GMP reductase 0.0107 0.0363 0.0464
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0124 0.1105
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1556 0.6448 1
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0107 0.0387
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0441 0.1576
Loa Loa (eye worm) hypothetical protein 0.0035 0.006 0.0028
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0047 0.0111 0.0973
Loa Loa (eye worm) GMP reductase 0.0047 0.0111 0.0591
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.006 0.0164 0.0176
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.011 0.0078
Onchocerca volvulus Huntingtin homolog 0.012 0.0417 0.6154
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0977 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0124 0.0729
Entamoeba histolytica hypothetical protein 0.0071 0.0213 0.5057
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0211 0.0211
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0648 0.632
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0101 0.0863
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0107 0.0363 0.0475
Brugia malayi RNA binding protein 0.0126 0.0441 0.4409
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0319 0.1133
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0594 0.241 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0281 0.1094 0.4281
Echinococcus granulosus tar DNA binding protein 0.0126 0.0441 0.1601
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.011 0.0091
Echinococcus multilocularis expressed conserved protein 0.009 0.0289 0.0289
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.011 0.0078
Echinococcus granulosus geminin 0.0205 0.0772 0.2803
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0101 0.0476
Echinococcus granulosus lysine specific demethylase 5A 0.0073 0.0219 0.0794
Loa Loa (eye worm) TAR-binding protein 0.0126 0.0441 0.4173
Loa Loa (eye worm) hypothetical protein 0.0035 0.006 0.0028
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0107 0.0387
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.0313 0.0313
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0047 0.0111 0.0081
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0611 0.5899
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0047 0.0111 0.0003
Brugia malayi hypothetical protein 0.0071 0.0213 0.2027
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0977 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0084 0.0296
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.011 0.0078
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0611 0.5899
Loa Loa (eye worm) hypothetical protein 0.0041 0.0084 0.0296
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0107 0.0363 0.1292
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0133 0.0484
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0084 0.0306
Loa Loa (eye worm) hypothetical protein 0.0035 0.006 0.0028
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0281 0.1094 0.3871
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.057
Loa Loa (eye worm) hypothetical protein 0.0043 0.0094 0.0396
Schistosoma mansoni hypothetical protein 0.0071 0.0213 0.0744
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0101 0.0338
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0107 0.0363 0.0487
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0107 0.0358
Schistosoma mansoni patched 1 0.0041 0.0084 0.0278
Brugia malayi AMP-binding enzyme family protein 0.0047 0.011 0.0954
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0107 0.0363 0.0464
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0101 0.0366
Brugia malayi GMP reductase 0.0047 0.0111 0.0973
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0977 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.011 0.0091
Brugia malayi Bromodomain containing protein 0.0076 0.0231 0.222
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0107 0.0363 0.0464
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0107 0.0363 0.1318
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0977 1
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.0611 1
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0107 0.0363 0.0363
Mycobacterium ulcerans hypothetical protein 0.0047 0.011 0.0078
Echinococcus multilocularis geminin 0.0205 0.0772 0.0772
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0107 0.0363 0.0464
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.011 0.0078
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0281 0.1094 0.3871
Brugia malayi TAR-binding protein 0.0126 0.0441 0.4409
Entamoeba histolytica hypothetical protein 0.0071 0.0213 0.5057
Loa Loa (eye worm) hypothetical protein 0.0041 0.0085 0.0308
Schistosoma mansoni hypothetical protein 0.0281 0.1093 0.395
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0213 0.0772
Schistosoma mansoni bromodomain containing protein 0.0064 0.0181 0.063
Loa Loa (eye worm) hypothetical protein 0.0046 0.0107 0.0537
Brugia malayi CHE-14 protein 0.0041 0.0084 0.069
Loa Loa (eye worm) RNA binding protein 0.0126 0.0441 0.4173
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.0441 0.4409
Schistosoma mansoni hypothetical protein 0.0039 0.0078 0.0255
Loa Loa (eye worm) hypothetical protein 0.012 0.0417 0.3911
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0101 0.0101
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0107 0.0363 1
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0107 0.0107
Schistosoma mansoni hypothetical protein 0.0039 0.0078 0.0255
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0107 0.0358
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.006 0.0013
Entamoeba histolytica hypothetical protein 0.0071 0.0213 0.5057
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0133 0.0133
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.011 0.0078
Entamoeba histolytica hypothetical protein 0.0071 0.0213 0.5057
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0124 0.1105
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0213 0.0744
Schistosoma mansoni hypothetical protein 0.0039 0.0078 0.0255
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.006 0.0164 0.0086
Loa Loa (eye worm) hypothetical protein 0.0035 0.006 0.0028
Leishmania major inosine-5-monophosphate dehydrogenase 0.0107 0.0363 0.1102
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0211 0.0765
Trypanosoma brucei GMP reductase 0.0107 0.0363 0.0464
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0611 0.5899
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0253 0.0977 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0133 0.0133
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0107 0.0363 1
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1556 0.6448 1
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0441 0.1576
Loa Loa (eye worm) MBCTL1 0.0053 0.0133 0.0829
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.0441 0.4173
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0611 0.5899
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0594 0.241 1
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0107 0.0363 0.5
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0107 0.0363 0.04
Trypanosoma cruzi GMP reductase 0.0107 0.0363 0.0464
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0441 0.1576
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0166 0.0603
Mycobacterium ulcerans hypothetical protein 0.0313 0.1228 0.1829
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0101 0.0338
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0102 0.034 0.0358
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.057
Echinococcus multilocularis protein patched 0.0041 0.0084 0.0084
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0101 0.0366
Toxoplasma gondii IMP dehydrogenas 0.0107 0.0363 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.0485 0.0485
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0107 0.0363 0.0475
Schistosoma mansoni microtubule-associated protein tau 0.0676 0.2755 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0065 0.0065
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0133 0.0484
Echinococcus granulosus expressed conserved protein 0.009 0.0289 0.1049
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.0219 0.0767
Onchocerca volvulus Huntingtin homolog 0.012 0.0417 0.6154
Leishmania major guanosine monophosphate reductase 0.0107 0.0363 0.1102
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.0485 0.1761
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.011 0.0078
Echinococcus multilocularis tar DNA binding protein 0.0126 0.0441 0.0441
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0594 0.241 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0182 0.0678 0.246
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.0313 0.3077
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0211 0.0738
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.0313 0.1137
Onchocerca volvulus 0.0047 0.011 0.0061
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0133 0.1202
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0107 0.0107
Schistosoma mansoni hypothetical protein 0.0205 0.0772 0.2782
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0107 0.0358
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0107 0.0537
Onchocerca volvulus Putative GMP reductase 0.0047 0.0111 0.0098
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0107 0.0363 0.3597
Loa Loa (eye worm) hypothetical protein 0.0047 0.011 0.057
Loa Loa (eye worm) hypothetical protein 0.0053 0.0133 0.0829
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0219 0.1758
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.0219 0.0767
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.006 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0057 0.0406
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0101 0.0101
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0035 0.006 0.0028
Mycobacterium ulcerans TetR family transcriptional regulator 0.1556 0.6448 1
Loa Loa (eye worm) IMP dehydrogenase 1 0.0107 0.0363 0.3326
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.0313 1
Brugia malayi Bromodomain containing protein 0.0039 0.0075 0.0593
Brugia malayi mbt repeat family protein 0.0046 0.0107 0.0922
Brugia malayi mbt repeat family protein 0.0046 0.0107 0.0922
Brugia malayi jmjC domain containing protein 0.0073 0.0219 0.2093
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0182 0.0678 0.0678
Schistosoma mansoni hypothetical protein 0.0034 0.0057 0.0178
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1556 0.6448 1
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0648 0.632
Mycobacterium tuberculosis Conserved hypothetical protein 0.0313 0.1228 0.1839
Loa Loa (eye worm) hypothetical protein 0.012 0.0417 0.3911
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.011 0.0078
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0611 0.5899
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0441 0.1576

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 120 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Activators of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells. (Class of assay: confirmatory) [Related pubchem assays: 1829 (Project Summary), 1814 (Primary HTS)] ChEMBL. No reference
Potency (functional) 0.1032 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3535 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 16.9441 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 20.7865 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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