Detailed information for compound 1408226

Basic information

Technical information
  • TDR Targets ID: 1408226
  • Name: ethyl 6-[5-[(5-cyano-4-oxo-6-phenyl-1H-pyrimi din-2-yl)sulfanylmethyl]-2-oxo-1,3-dihydroimi dazol-4-yl]-6-oxohexanoate
  • MW: 481.524 | Formula: C23H23N5O5S
  • H donors: 3 H acceptors: 8 LogP: 3.46 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)CCCCC(=O)c1[nH]c(nc1CSc1nc(O)c(c(n1)c1ccccc1)C#N)O
  • InChi: 1S/C23H23N5O5S/c1-2-33-18(30)11-7-6-10-17(29)20-16(25-22(32)26-20)13-34-23-27-19(14-8-4-3-5-9-14)15(12-24)21(31)28-23/h3-5,8-9H,2,6-7,10-11,13H2,1H3,(H2,25,26,32)(H,27,28,31)
  • InChiKey: PVSZILJUJHCSJB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 6-[5-[(5-cyano-4-oxo-6-phenyl-1H-pyrimidin-2-yl)sulfanylmethyl]-2-oxo-1,3-dihydroimidazol-4-yl]-6-oxo-hexanoate
  • 6-[5-[[(5-cyano-4-oxo-6-phenyl-1H-pyrimidin-2-yl)thio]methyl]-2-oxo-1,3-dihydroimidazol-4-yl]-6-oxohexanoic acid ethyl ester
  • 6-[5-[[(5-cyano-4-keto-6-phenyl-1H-pyrimidin-2-yl)thio]methyl]-2-keto-1,3-dihydroimidazol-4-yl]-6-keto-hexanoic acid ethyl ester
  • ZINC02864501
  • MLS000050818
  • SMR000078445
  • ethyl 6-(5-{[(5-cyano-6-oxo-4-phenyl-1,6-dihydro-2-pyrimidinyl)thio]methyl}-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-6-oxohexanoate
  • MLS000863092

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens ABL proto-oncogene 1, non-receptor tyrosine kinase No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens Ras and Rab interactor 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus granulosus tyrosine protein kinase ABL1 Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase ABL1, putative Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis tyrosine protein kinase ABL1 Get druggable targets OG5_131234 All targets in OG5_131234
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131234 All targets in OG5_131234
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi Tyrosine-protein kinase abl-1 Get druggable targets OG5_131234 All targets in OG5_131234
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) TK/ABL protein kinase Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum expressed protein Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma japonicum Tyrosine-protein kinase transforming protein Abl, putative Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus multilocularis tyrosine protein kinase Abl Get druggable targets OG5_131234 All targets in OG5_131234
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Tyrosine-protein kinase transforming protein Abl, putative Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma japonicum expressed protein Get druggable targets OG5_131234 All targets in OG5_131234
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0008 0.0003 0.0012
Echinococcus granulosus G protein coupled receptor 139 0.0037 0.0078 0.0363
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0254 0.0644 0.2984
Brugia malayi cation channel family protein 0.001 0.0007 0.0097
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0097
Echinococcus multilocularis transient receptor potential cation channel 0.001 0.0007 0.0033
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.001 0.0007 0.0097
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0014 0.0017 0.0237
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.0727 0.337
Trypanosoma cruzi cAMP binding protein, putative 0.002 0.0033 0.1423
Schistosoma mansoni hypothetical protein 0.0037 0.0078 0.0363
Echinococcus multilocularis neuropeptide receptor 0.0037 0.0078 0.0363
Echinococcus granulosus potassium voltage gated channel subfamily D 0.001 0.0007 0.0033
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0028 0.0055 0.0022
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.002 0.0033 0.036
Echinococcus multilocularis neuropeptide s receptor 0.0037 0.0078 0.0363
Echinococcus granulosus cyclic nucleotide gated cation channel 0.002 0.0033 0.0153
Brugia malayi SRC-1 0.0008 0.0003 0.0037
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.001 0.0007 0.0097
Echinococcus granulosus 7TM GPCR rhodopsin 0.0037 0.0078 0.0363
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.001 0.0007 0.0097
Schistosoma mansoni 60S ribosomal protein L21 0.0024 0.0043 0.0199
Brugia malayi Cyclic-nucleotide gated cation channel 0.003 0.0059 0.0808
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.002 0.0033 0.0153
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0078 0.0363
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.001 0.0007 0.0033
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0173 0.0801
Echinococcus granulosus neuropeptide Y receptor 0.0037 0.0078 0.0363
Schistosoma mansoni survival motor neuron protein 0.0058 0.0133 0.0618
Echinococcus multilocularis voltage gated hydrogen channel 1 0.001 0.0007 0.0033
Echinococcus granulosus neuropeptide receptor 0.0037 0.0078 0.0363
Leishmania major hypothetical protein, conserved 0.002 0.0033 0.1423
Echinococcus granulosus TRP transient receptor potential channel 0.001 0.0007 0.0033
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0078 0.0363
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0078 0.0363
Leishmania major cyclic nucleotide-binding protein-like protein 0.002 0.0033 0.1423
Loa Loa (eye worm) neuropeptide F receptor 0.0037 0.0078 0.1076
Onchocerca volvulus 0.0037 0.0078 0.0987
Schistosoma mansoni opsin-like receptor 0.0037 0.0078 0.0363
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.0078 0.0363
Schistosoma mansoni biogenic amine (5HT) receptor 0.0037 0.0078 0.0363
Schistosoma mansoni biogenic amine receptor 0.0037 0.0078 0.0363
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.003 0.0059 0.0808
Echinococcus granulosus sex peptide receptor 0.0037 0.0078 0.0363
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0189 0.2606
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0078 0.0363
Schistosoma mansoni voltage-gated potassium channel 0.0164 0.0409 0.1896
Schistosoma mansoni histamine h1 receptor 0.0037 0.0078 0.0363
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0043 0.0095 0.0439
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0037 0.0078 0.0363
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.003 0.0059 0.0584
Echinococcus granulosus voltage gated potassium channel 0.0043 0.0095 0.0439
Echinococcus multilocularis neuropeptide FF receptor 2 0.0037 0.0078 0.0363
Plasmodium vivax SET domain protein, putative 0.0036 0.0075 0.0043
Echinococcus granulosus tyrosine protein kinase ABL1 0.0254 0.0644 0.2984
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.001 0.0007 0.0033
Brugia malayi hypothetical protein 0.0037 0.0078 0.1076
Echinococcus granulosus two pore calcium channel protein 2 0.001 0.0007 0.0033
Schistosoma mansoni amine GPCR 0.0037 0.0078 0.0363
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Schistosoma mansoni hypothetical protein 0.0037 0.0078 0.0363
Schistosoma mansoni opsin-like receptor 0.0037 0.0078 0.0363
Schistosoma mansoni transient receptor potential channel 4 0.001 0.0007 0.0033
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0037 0.0078 0.0363
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0078 0.0363
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0097
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0008 0.0003 0.0012
Brugia malayi hypothetical protein 0.0037 0.0078 0.1076
Echinococcus multilocularis G-protein coupled receptor, putative 0.0037 0.0078 0.0363
Echinococcus granulosus orexin receptor type 2 0.0037 0.0078 0.0363
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0078 0.0363
Echinococcus granulosus sodium leak channel non selective protein 0.001 0.0007 0.0033
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Schistosoma mansoni amine GPCR 0.0037 0.0078 0.0363
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.001 0.0007 0.0033
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.001 0.0007 0.0033
Schistosoma mansoni inositol 145-trisphosphate receptor 0.001 0.0007 0.0033
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0033 0.0153
Brugia malayi hypothetical protein 0.001 0.0007 0.0097
Loa Loa (eye worm) hypothetical protein 0.0043 0.0095 0.1303
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.015 0.0373 0.5131
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0078 0.0363
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0007 0.0033
Echinococcus multilocularis neuropeptide Y receptor 0.0037 0.0078 0.0363
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.001 0.0007 0.0097
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0078 0.0363
Echinococcus multilocularis potassium voltage gated channel protein 0.001 0.0007 0.0033
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0097
Schistosoma mansoni tyrosine kinase 0.025 0.0634 0.294
Schistosoma mansoni tyrosine kinase 0.0008 0.0003 0.0012
Trypanosoma cruzi protein kinase A regulatory subunit 0.002 0.0033 0.1423
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.002 0.0033 0.0026
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0055 0.263
Echinococcus granulosus g protein coupled receptor 0.0037 0.0078 0.0363
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0037 0.0078 0.1076
Schistosoma mansoni amine GPCR 0.0037 0.0078 0.0363
Echinococcus multilocularis calcium activated potassium channel 0.001 0.0007 0.0033
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0078 0.0363
Brugia malayi G protein-coupled receptor 0.0037 0.0078 0.1076
Echinococcus multilocularis sodium channel protein 0.001 0.0007 0.0033
Echinococcus granulosus neuropeptide receptor A26 0.0037 0.0078 0.0363
Loa Loa (eye worm) voltage-gated potassium channel 0.001 0.0007 0.0097
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0007 0.0033
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.002 0.0033 0.1423
Echinococcus granulosus hypothetical protein 0.001 0.0007 0.0033
Brugia malayi putative neuropeptide receptor 0.0037 0.0078 0.1076
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.001 0.0007 0.0033
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.014 0.0347 0.4641
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0189 0.0878
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0055 0.0022
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0173 0.014
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.003 0.0059 0.0272
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0078 0.0363
Leishmania major hypothetical protein, conserved 0.002 0.0033 0.1423
Schistosoma mansoni voltage-gated cation channel 0.001 0.0007 0.0033
Schistosoma mansoni two-pore calcium channel 0.001 0.0007 0.0033
Brugia malayi Tyrosine-protein kinase abl-1 0.0103 0.0251 0.3458
Onchocerca volvulus 0.002 0.0033 0.036
Schistosoma mansoni tyrosine kinase 0.0008 0.0003 0.0012
Echinococcus multilocularis TRP (transient receptor potential) channel 0.001 0.0007 0.0033
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0454
Echinococcus granulosus short transient receptor potential channel 6 0.001 0.0007 0.0033
Brugia malayi hypothetical protein 0.0286 0.0727 1
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.002 0.0033 0.0221
Echinococcus granulosus microtubule associated protein 2 0.0833 0.2157 1
Brugia malayi AKH receptor 0.0037 0.0078 0.1076
Echinococcus multilocularis shaker cognate 0.001 0.0007 0.0033
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.002 0.0033 0.0221
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.001 0.0007 0.0097
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0097
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.001 0.0007 0.0033
Schistosoma mansoni voltage-gated potassium channel 0.003 0.0059 0.0272
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0075 0.0349
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0102 0.0472
Leishmania major protein kinase, putative 0.002 0.0033 0.1423
Echinococcus multilocularis muscleblind protein 0.018 0.0452 0.2097
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0078 0.0363
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0037 0.0078 0.0363
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0097
Brugia malayi Tyrosine-protein kinase abl-1 0.0154 0.0383 0.5269
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Mycobacterium leprae conserved hypothetical protein 0.0028 0.0055 0.0038
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0173 0.014
Echinococcus granulosus hyperpolarization activated cyclic 0.003 0.0059 0.0272
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.001 0.0007 0.0033
Schistosoma mansoni adenoreceptor 0.0037 0.0078 0.0363
Schistosoma mansoni alpha-1 adrenergic receptor 0.0037 0.0078 0.0363
Echinococcus multilocularis neuropeptide receptor A26 0.0037 0.0078 0.0363
Echinococcus multilocularis somatostatin receptor 0.0037 0.0078 0.0363
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.0043 0.0199
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.003 0.0059 0.0272
Brugia malayi Pre-SET motif family protein 0.0036 0.0075 0.1037
Echinococcus granulosus potassium large conductance calcium activated 0.001 0.0007 0.0033
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.002 0.0033 0.0153
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0055 0.0024
Echinococcus multilocularis sodium leak channel non selective protein 0.001 0.0007 0.0033
Echinococcus multilocularis transient receptor potential cation channel 0.001 0.0007 0.0033
Brugia malayi Melatonin receptor type 1A 0.0037 0.0078 0.1076
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0078 0.0363
Loa Loa (eye worm) voltage-gated potassium channel 0.001 0.0007 0.0097
Echinococcus multilocularis neuropeptides capa receptor 0.0037 0.0078 0.0363
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.001 0.0007 0.0097
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0097
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0097
Echinococcus multilocularis transfer RNA-Gly 0.001 0.0007 0.0033
Echinococcus granulosus shaker cognate 0.001 0.0007 0.0033
Schistosoma mansoni hypothetical protein 0.0058 0.0133 0.0618
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.002 0.0033 0.0454
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0097
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.001 0.0007 0.0097
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.001 0.0007 0.0033
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0055 0.0022
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.002 0.0033 0.0153
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0097
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0033 0.0153
Loa Loa (eye worm) hypothetical protein 0.013 0.0321 0.4419
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.001 0.0007 0.0033
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0189 0.0878
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0078 0.0363
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.001 0.0007 0.0097
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0097
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0037 0.0078 0.0363
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.001 0.0007 0.0033
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Echinococcus granulosus g-protein coupled receptor 0.0037 0.0078 0.0363
Schistosoma mansoni biogenic amine (5HT) receptor 0.0037 0.0078 0.0363
Loa Loa (eye worm) G-protein coupled receptor 0.0037 0.0078 0.1076
Brugia malayi hypothetical protein 0.0037 0.0078 0.1076
Echinococcus granulosus hyperpolarization activated cyclic 0.003 0.0059 0.0272
Echinococcus granulosus peptide allatostatin:somatostatin 0.0037 0.0078 0.0363
Brugia malayi Tachykinin-like peptides receptor 99D 0.0037 0.0078 0.1076
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.0637 0.877
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0033 0.0153
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.001 0.0007 0.0033
Echinococcus multilocularis fmrfamide receptor 0.0037 0.0078 0.0363
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.002 0.0033 0.0153
Schistosoma mansoni tyrosine kinase 0.0008 0.0003 0.0012
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0008 0.0003 0.0012
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.003 0.0059 0.0808
Schistosoma mansoni tyrosine kinase 0.0008 0.0003 0.0012
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0189 1
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.2157 1
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0007 0.0033
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0043 0.0095 0.0439
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.002 0.0033 0.0026
Echinococcus multilocularis potassium large conductance calcium activated 0.001 0.0007 0.0033
Onchocerca volvulus Neuropeptide F receptor homolog 0.0037 0.0078 0.0987
Onchocerca volvulus 0.0037 0.0078 0.0987
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0075 0.0349
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.003 0.0059 0.0272
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0037 0.0078 0.0363
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.001 0.0007 0.0033
Schistosoma mansoni biogenic amine receptor 0.0037 0.0078 0.0363
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0097
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0078 0.0363
Onchocerca volvulus 0.0037 0.0078 0.0987
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0189 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.001 0.0007 0.0033
Brugia malayi Pre-SET motif family protein 0.0251 0.0637 0.877
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.002 0.0033 0.0153
Echinococcus multilocularis neuropeptide Y receptor 0.0037 0.0078 0.0363
Echinococcus multilocularis short transient receptor potential channel 6 0.001 0.0007 0.0033
Echinococcus granulosus muscleblind protein 0.018 0.0452 0.2097
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0037 0.0078 0.1076
Schistosoma mansoni growth hormone secretagogue receptor 0.0037 0.0078 0.0363
Onchocerca volvulus 0.0058 0.0133 0.1752
Echinococcus multilocularis sex peptide receptor 0.0037 0.0078 0.0363
Onchocerca volvulus 0.0037 0.0078 0.0987
Loa Loa (eye worm) hypothetical protein 0.0096 0.0233 0.32
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0095 0.0439
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0037 0.0078 0.0363
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Echinococcus multilocularis two pore calcium channel protein 2 0.001 0.0007 0.0033
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0078 0.0363
Onchocerca volvulus 0.0037 0.0078 0.0987
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.003 0.0059 0.0272
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.002 0.0033 0.1423
Onchocerca volvulus 0.01 0.0243 0.3278
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0055 0.0022
Echinococcus granulosus dro:myosuppressin receptor 0.0037 0.0078 0.0363
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0075 0.0349
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Echinococcus granulosus voltage gated hydrogen channel 1 0.001 0.0007 0.0033
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0037 0.0078 0.0363
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.0243 0.1128
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0037 0.0078 0.0363
Brugia malayi follicle stimulating hormone receptor 0.0037 0.0078 0.1076
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Echinococcus multilocularis neuropeptide receptor 0.0037 0.0078 0.0363
Brugia malayi voltage-dependent calcium channel 0.001 0.0007 0.0097
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0037 0.0078 0.1076
Echinococcus granulosus potassium voltage gated channel protein 0.001 0.0007 0.0033
Echinococcus granulosus neuropeptide s receptor 0.0037 0.0078 0.0363
Leishmania major regulatory subunit of protein kinase a-like protein 0.002 0.0033 0.1423
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0008 0.0003 0.0012
Echinococcus granulosus neuropeptides capa receptor 0.0037 0.0078 0.0363
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Echinococcus multilocularis muscleblind protein 1 0.018 0.0452 0.2097
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.0727 0.337
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0037 0.0078 0.0363
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0055 0.0022
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0078 0.0363
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0055 0.0048
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0037 0.0078 0.1076
Onchocerca volvulus 0.0037 0.0078 0.0987
Echinococcus multilocularis allatostatin A receptor 0.0037 0.0078 0.0363
Schistosoma mansoni neuropeptide receptor 0.0037 0.0078 0.0363
Echinococcus granulosus transient receptor potential cation channel 0.001 0.0007 0.0033
Schistosoma mansoni voltage-gated potassium channel 0.0164 0.0409 0.1896
Echinococcus multilocularis transient receptor potential cation channel 0.001 0.0007 0.0033
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0189 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0059 0.0808
Echinococcus granulosus transient receptor potential cation channel 0.001 0.0007 0.0033
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.001 0.0007 0.0033
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.002 0.0033 0.0454
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.3483 0.9073 1
Echinococcus granulosus transient receptor potential cation channel 0.001 0.0007 0.0033
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0007 0.0033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0078 0.0363
Schistosoma mansoni similar to Protein C20orf152 homolog 0.002 0.0033 0.0153
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0008 0.0003 0.0012
Echinococcus granulosus serotonin receptor 0.0037 0.0078 0.0363
Echinococcus granulosus c src tyrosine kinase 0.0008 0.0003 0.0012
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0008 0.0003 0.0012
Echinococcus granulosus potassium voltage gated channel subfamily H 0.015 0.0373 0.1729
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0078 0.0363
Echinococcus multilocularis voltage dependent calcium channel 0.001 0.0007 0.0033
Trichomonas vaginalis set domain proteins, putative 0.0286 0.0728 1
Brugia malayi putative neuropeptide receptor NPR1 0.0037 0.0078 0.1076
Brugia malayi hypothetical protein 0.0037 0.0078 0.1076
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0097
Brugia malayi hypothetical protein 0.0037 0.0078 0.1076
Onchocerca volvulus 0.0037 0.0078 0.0987
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.001 0.0007 0.0097
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0037 0.0078 0.0363
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.002 0.0033 0.0153
Echinococcus granulosus allatostatin A receptor 0.0037 0.0078 0.0363
Brugia malayi neuropeptide F receptor 0.0037 0.0078 0.1076
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.001 0.0007 0.0033
Echinococcus multilocularis neuropeptides capa receptor 0.0037 0.0078 0.0363
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0097
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0008 0.0003 0.0012
Schistosoma mansoni neuropeptide F-like receptor 0.0037 0.0078 0.0363
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0078 0.0363
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.002 0.0033 0.0026
Onchocerca volvulus 0.0037 0.0078 0.0987
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Loa Loa (eye worm) calcium channel 0.001 0.0007 0.0097
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0007 0.0033
Onchocerca volvulus 0.0036 0.0075 0.0948
Echinococcus granulosus transient receptor potential cation channel 0.001 0.0007 0.0033
Loa Loa (eye worm) hypothetical protein 0.0036 0.0075 0.1037
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0037 0.0078 0.1076
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0037 0.0078 0.0363
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0037 0.0078 0.1076
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.002 0.0033 0.0454
Loa Loa (eye worm) AGC/PKG protein kinase 0.002 0.0033 0.0454
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.014 0.0347 0.4641
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0007 0.0033
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0078 0.0363
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.001 0.0007 0.0033
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.001 0.0007 0.0033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0078 0.0363
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0033 0.1423
Echinococcus granulosus voltage dependent calcium channel 0.001 0.0007 0.0033
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.015 0.0373 0.1729
Schistosoma mansoni hypothetical protein 0.0037 0.0078 0.0363
Brugia malayi Serotonin receptor 0.0037 0.0078 0.1076
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.002 0.0033 0.0153
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0008 0.0003 0.0012
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.002 0.0033 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0075 0.0349
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.001 0.0007 0.0033
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.002 0.0033 0.0026
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Echinococcus granulosus cGMP dependent protein kinase 1 0.002 0.0033 0.0153
Loa Loa (eye worm) ryanodine receptor 0.001 0.0007 0.0097
Echinococcus granulosus patatin phospholipase domain containing protein 0.002 0.0033 0.0153
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.002 0.0033 0.0153
Echinococcus granulosus tyrosine protein kinase Lyn 0.0008 0.0003 0.0012
Echinococcus multilocularis hyperpolarization activated cyclic 0.003 0.0059 0.0272
Onchocerca volvulus 0.0037 0.0078 0.0987
Echinococcus granulosus transient receptor potential gamma protein 0.001 0.0007 0.0033
Schistosoma mansoni neuropeptide F-like receptor 0.0037 0.0078 0.0363
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0033 0.0221
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0173 0.0801
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.002 0.0033 0.0454
Brugia malayi N-terminal motif family protein 0.002 0.0033 0.0454
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0037 0.0078 0.0363
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.001 0.0007 0.0033
Schistosoma mansoni biogenic amine receptor 0.0037 0.0078 0.0363
Schistosoma mansoni neuropeptide f receptor 76f 0.0037 0.0078 0.0363
Brugia malayi RE15519p 0.0037 0.0078 0.1076
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0037 0.0078 0.0363
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Echinococcus granulosus voltage gated potassium channel 0.001 0.0007 0.0033
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.0243 0.1128
Schistosoma mansoni amine GPCR 0.0037 0.0078 0.0363
Brugia malayi Dopamine receptor protein 1 0.0037 0.0078 0.1076
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0037 0.0078 0.0363
Brugia malayi G-protein coupled receptor 0.0037 0.0078 0.1076
Schistosoma mansoni voltage-gated ion channel 0.001 0.0007 0.0033
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0008 0.0003 0.0012
Echinococcus multilocularis expressed conserved protein 0.002 0.0033 0.0153
Echinococcus granulosus somatostatin receptor 0.0037 0.0078 0.0363
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0173 0.0801
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.0243 0.3349
Brugia malayi hypothetical protein 0.0037 0.0078 0.1076
Onchocerca volvulus 0.0037 0.0078 0.0987
Leishmania major protein kinase, putative 0.002 0.0033 0.1423
Loa Loa (eye worm) G-protein coupled receptor 0.0037 0.0078 0.1076
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0037 0.0078 0.0363
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.002 0.0033 0.1423
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.002 0.0033 0.0153
Echinococcus granulosus short transient receptor potential channel 6 0.001 0.0007 0.0033
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0072 0.0333
Onchocerca volvulus 0.0037 0.0078 0.0987
Echinococcus granulosus cGMP dependent protein kinase 0.002 0.0033 0.0153
Echinococcus multilocularis potassium voltage gated channel protein 0.001 0.0007 0.0033
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.002 0.0033 0.0026
Echinococcus multilocularis orexin receptor type 2 0.0037 0.0078 0.0363
Echinococcus multilocularis cGMP dependent protein kinase 1 0.002 0.0033 0.0153
Echinococcus granulosus cyclic nucleotide gated cation channel 0.003 0.0059 0.0272
Echinococcus granulosus potassium voltage gated channel subfamily C 0.001 0.0007 0.0033
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0037 0.0078 0.0363
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.001 0.0007 0.0097
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0102 0.0472
Leishmania major hypothetical protein, conserved 0.002 0.0033 0.1423
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0037 0.0078 0.1076
Echinococcus granulosus transient receptor potential cation channel 0.001 0.0007 0.0033
Echinococcus granulosus cGMP dependent protein kinase 1 0.002 0.0033 0.0153
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0037 0.0078 0.1076
Onchocerca volvulus 0.0037 0.0078 0.0987
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.015 0.0373 0.5131
Onchocerca volvulus 0.0037 0.0078 0.0987
Brugia malayi olfactory channel protein osm-9 0.001 0.0007 0.0097
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Echinococcus granulosus tyrosine protein kinase Fyn 0.0008 0.0003 0.0012
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Loa Loa (eye worm) ion channel NompC 0.001 0.0007 0.0097
Echinococcus granulosus hypothetical protein 0.0037 0.0078 0.0363
Trypanosoma brucei cAMP response protein 1, putative 0.002 0.0033 0.1423
Echinococcus granulosus tyrosine protein kinase Src64B 0.0008 0.0003 0.0012
Echinococcus granulosus cyclic nucleotide gated cation channel 0.003 0.0059 0.0272
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0043 0.0095 0.1303
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0037 0.0078 0.0363
Brugia malayi G-protein coupled receptor 0.0037 0.0078 0.1076
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0008 0.0003 0.0012
Brugia malayi hypothetical protein 0.0037 0.0078 0.1076
Loa Loa (eye worm) SRC-1 0.0008 0.0003 0.0037
Trypanosoma cruzi cAMP response protein 1 0.002 0.0033 0.1423
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0454
Trypanosoma cruzi cAMP response protein 1, putative 0.002 0.0033 0.1423
Schistosoma mansoni neuropeptide receptor 0.0037 0.0078 0.0363
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0189 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0037 0.0078 0.0363
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.001 0.0007 0.0033
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0037 0.0078 0.1076
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0037 0.0078 0.0363
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0173 0.0801
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0033 0.0221
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.0078 0.0363
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0008 0.0003 0.0012
Schistosoma mansoni neuropeptide receptor 0.0037 0.0078 0.0363
Echinococcus granulosus potassium voltage gated channel protein 0.001 0.0007 0.0033
Echinococcus granulosus potassium voltage gated channel protein 0.001 0.0007 0.0033
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.003 0.0059 0.0272
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0055 0.263
Schistosoma mansoni myosin xvIII 0.0037 0.0078 0.0363
Brugia malayi hypothetical protein 0.0037 0.0078 0.1076
Trypanosoma brucei cAMP binding protein, putative 0.002 0.0033 0.1423
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.001 0.0007 0.0097
Echinococcus granulosus calcium activated potassium channel 0.001 0.0007 0.0033
Schistosoma mansoni hypothetical protein 0.002 0.0033 0.0153
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.002 0.0033 0.0026
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0075 0.0068
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.003 0.0059 0.0584
Onchocerca volvulus 0.0286 0.0728 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.001 0.0007 0.0033
Loa Loa (eye worm) hypothetical protein 0.01 0.0243 0.3349
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.003 0.0059 0.0272
Echinococcus granulosus potassium voltage gated channel protein 0.001 0.0007 0.0033
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0037 0.0078 0.0363
Schistosoma mansoni calcium-activated potassium channel 0.001 0.0007 0.0033
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Echinococcus granulosus neuropeptides capa receptor 0.0037 0.0078 0.0363
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0075 0.0349
Onchocerca volvulus 0.0037 0.0078 0.0987
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0008 0.0003 0.0012
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0037 0.0078 0.0363
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.0033 0.0153
Echinococcus granulosus potassium voltage gated channel subfamily D 0.001 0.0007 0.0033
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.001 0.0007 0.0097
Echinococcus multilocularis g-protein coupled receptor 0.0037 0.0078 0.0363
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0097
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Brugia malayi sulfakinin receptor protein 0.0037 0.0078 0.1076
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.002 0.0033 0.1423
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.001 0.0007 0.0033
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Onchocerca volvulus 0.0037 0.0078 0.0987
Loa Loa (eye worm) hypothetical protein 0.018 0.0452 0.6222
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0007 0.0033
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0173 0.9085
Schistosoma mansoni transient receptor potential channel 0.001 0.0007 0.0033
Echinococcus multilocularis serotonin receptor 0.0037 0.0078 0.0363
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.2157 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0037 0.0078 0.1076
Echinococcus multilocularis tyrosine protein kinase Abl 0.0103 0.0251 0.1165
Brugia malayi GnHR receptor homolog 0.0037 0.0078 0.1076
Echinococcus multilocularis fmrfamide receptor 0.0037 0.0078 0.0363
Brugia malayi ORL1-like opioid receptor 0.0037 0.0078 0.1076
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.0078 0.0363
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.0243 0.1128
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0189 1
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.001 0.0007 0.0033
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.002 0.0033 0.0153
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0037 0.0078 0.0363
Echinococcus multilocularis G protein coupled receptor 139 0.0037 0.0078 0.0363
Echinococcus multilocularis hyperpolarization activated cyclic 0.003 0.0059 0.0272
Echinococcus multilocularis g protein coupled receptor 0.0037 0.0078 0.0363
Brugia malayi Transient-receptor-potential like protein 0.001 0.0007 0.0097
Echinococcus granulosus voltage dependent calcium channel 0.001 0.0007 0.0033
Echinococcus multilocularis conserved hypothetical protein 0.001 0.0007 0.0033
Onchocerca volvulus 0.002 0.0033 0.036
Echinococcus granulosus transient receptor potential cation channel 0.001 0.0007 0.0033
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.002 0.0033 0.0153
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Echinococcus granulosus two pore calcium channel protein 1 0.001 0.0007 0.0033
Leishmania major hypothetical protein, unknown function 0.002 0.0033 0.1423
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.002 0.0033 0.0153
Leishmania major protein kinase A regulatory subunit, putative 0.002 0.0033 0.1423
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0033 0.0221
Schistosoma mansoni neuropeptide receptor 0.0037 0.0078 0.0363
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0037 0.0078 0.0363
Echinococcus granulosus single minded 2 0.0014 0.0017 0.008
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.002 0.0033 0.0153
Loa Loa (eye worm) TK/ABL protein kinase 0.0254 0.0644 0.8857
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.002 0.0033 0.0153
Brugia malayi hypothetical protein 0.0037 0.0078 0.1076
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0133 0.1834
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.001 0.0007 0.0033
Echinococcus multilocularis potassium voltage gated channel protein 0.001 0.0007 0.0033
Echinococcus granulosus g protein coupled receptor 0.0037 0.0078 0.0363
Echinococcus multilocularis ryanodine receptor 44f 0.001 0.0007 0.0033
Echinococcus multilocularis dro:myosuppressin receptor 0.0037 0.0078 0.0363
Echinococcus granulosus g protein coupled receptor 0.0037 0.0078 0.0363
Schistosoma mansoni ryanodine receptor related 0.001 0.0007 0.0033
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0007 0.0033
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0097
Brugia malayi Dopamine receptor 0.0037 0.0078 0.1076
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0078 0.0363
Echinococcus granulosus ryanodine receptor 44f 0.001 0.0007 0.0033
Echinococcus granulosus potassium voltage gated channel subfamily D 0.001 0.0007 0.0033
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.002 0.0033 0.0153
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.003 0.0059 0.0272
Loa Loa (eye worm) hypothetical protein 0.0286 0.0727 1
Echinococcus granulosus potassium voltage gated channel protein 0.001 0.0007 0.0033
Schistosoma mansoni opsin-like receptor 0.0037 0.0078 0.0363
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0007 0.0033
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Echinococcus multilocularis serotonin receptor 0.0037 0.0078 0.0363
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0095 0.0439
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0078 0.0363
Echinococcus multilocularis transient receptor potential cation channel 0.001 0.0007 0.0033
Brugia malayi ion channel NompC 0.001 0.0007 0.0097
Echinococcus granulosus sodium channel protein 0.001 0.0007 0.0033
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0037 0.0078 0.0363
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0173 0.0155
Mycobacterium leprae Conserved hypothetical protein 0.002 0.0033 0.0016
Echinococcus multilocularis short transient receptor potential channel 6 0.001 0.0007 0.0033
Echinococcus granulosus neuropeptide Y receptor 0.0037 0.0078 0.0363
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0037 0.0078 0.0363
Echinococcus multilocularis voltage dependent calcium channel 0.001 0.0007 0.0033
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0097
Echinococcus granulosus neuropeptide receptor 0.0037 0.0078 0.0363
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.003 0.0059 0.0272
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0173 0.0166
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0173 0.014
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Loa Loa (eye worm) melatonin receptor type 1A 0.0037 0.0078 0.1076
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0007 0.0033
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0037 0.0078 0.0363
Brugia malayi G protein-coupled receptor F59B2.13 0.0037 0.0078 0.1076
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0075 0.0349
Schistosoma mansoni transient receptor potential channel 0.001 0.0007 0.0033
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0037 0.0078 0.0987
Schistosoma mansoni amine GPCR 0.0037 0.0078 0.0363
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.003 0.0059 0.0272
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Schistosoma mansoni hypothetical protein 0.001 0.0007 0.0033
Brugia malayi Muscleblind-like protein 0.018 0.0452 0.6222
Trypanosoma cruzi Flagellar Member 6 0.002 0.0033 0.1423
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.0078 0.0363
Schistosoma mansoni hypothetical protein 0.0014 0.0017 0.008
Echinococcus multilocularis voltage gated potassium channel 0.0043 0.0095 0.0439
Echinococcus granulosus alpha 1A adrenergic receptor 0.0037 0.0078 0.0363
Onchocerca volvulus 0.0037 0.0078 0.0987
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.002 0.0033 0.0153
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0007 0.0033
Trypanosoma brucei STE group serine/threonine-protein kinase, putative 0.0014 0.0017 0.056
Echinococcus multilocularis voltage gated potassium channel 0.001 0.0007 0.0033
Brugia malayi Dopamine receptor protein 2 0.0037 0.0078 0.1076
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.001 0.0007 0.0097
Brugia malayi cation channel family protein 0.001 0.0007 0.0097
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0097
Echinococcus granulosus 7tm_1 domain containing protein 0.0037 0.0078 0.0363
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.002 0.0033 0.1423
Echinococcus multilocularis transient receptor potential cation channel 0.001 0.0007 0.0033
Loa Loa (eye worm) hypothetical protein 0.018 0.0452 0.6222
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0028 0.0055 0.0022
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0055 0.0048
Echinococcus multilocularis patatin phospholipase domain containing protein 0.002 0.0033 0.0153
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0037 0.0078 0.0363
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.001 0.0007 0.0033
Loa Loa (eye worm) neuropeptide F receptor 0.0037 0.0078 0.1076
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.002 0.0033 0.0153
Echinococcus multilocularis cGMP dependent protein kinase 1 0.002 0.0033 0.0153
Echinococcus granulosus tyrosine protein kinase Src42A 0.0008 0.0003 0.0012
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Echinococcus granulosus fmrfamide receptor 0.0037 0.0078 0.0363
Echinococcus multilocularis potassium voltage gated channel protein 0.001 0.0007 0.0033
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0037 0.0078 0.0363
Trypanosoma brucei Flagellar Member 6 0.002 0.0033 0.1423
Loa Loa (eye worm) voltage-gated calcium channel 0.001 0.0007 0.0097
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0008 0.0003 0.0012
Brugia malayi larval opioid receptor 0.0037 0.0078 0.1076
Onchocerca volvulus 0.0037 0.0078 0.0987
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.001 0.0007 0.0033
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0008 0.0003 0.0012
Schistosoma mansoni transient receptor potential channel 0.001 0.0007 0.0033
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0078 0.0363
Loa Loa (eye worm) TYRA-2 protein 0.0037 0.0078 0.1076
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Brugia malayi neuropeptide F receptor 0.0037 0.0078 0.1076
Echinococcus multilocularis transient receptor potential gamma protein 0.001 0.0007 0.0033
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0097
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.002 0.0033 0.0153
Brugia malayi hypothetical protein 0.0037 0.0078 0.1076
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.001 0.0007 0.0033
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0007 0.0033
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0189 0.0878
Echinococcus granulosus potassium voltage gated channel subfamily A 0.001 0.0007 0.0033
Echinococcus granulosus tm gpcr rhodopsin 0.0037 0.0078 0.0363
Brugia malayi Serotonin receptor 0.0037 0.0078 0.1076
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0097
Echinococcus granulosus biogenic amine 5HT receptor 0.0037 0.0078 0.0363
Brugia malayi Egg laying defective protein 4 0.002 0.0033 0.0454
Echinococcus granulosus neuropeptide FF receptor 2 0.0037 0.0078 0.0363
Echinococcus granulosus tachykinin peptides receptor 99D 0.0037 0.0078 0.0363
Schistosoma mansoni hypothetical protein 0.0037 0.0078 0.0363
Echinococcus granulosus biogenic amine 5HT receptor 0.0037 0.0078 0.0363
Echinococcus multilocularis two pore calcium channel protein 1 0.001 0.0007 0.0033
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0189 0.2606
Echinococcus granulosus tyrosine protein kinase Fyn 0.0008 0.0003 0.0012
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0037 0.0078 0.0363
Loa Loa (eye worm) voltage-dependent calcium channel 0.001 0.0007 0.0097
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0075 0.0349
Trypanosoma brucei protein kinase A regulatory subunit 0.002 0.0033 0.1423
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0078 0.0363
Echinococcus granulosus tyrosine protein kinase Fyn 0.0008 0.0003 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.0037 0.0078 0.0363
Echinococcus multilocularis c src tyrosine kinase 0.0008 0.0003 0.0012
Loa Loa (eye worm) hypothetical protein 0.0037 0.0078 0.1076
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0037 0.0078 0.0363
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0037 0.0078 0.0363
Schistosoma mansoni voltage-dependent calcium channel 0.001 0.0007 0.0033
Echinococcus multilocularis transient receptor potential cation channel 0.001 0.0007 0.0033
Schistosoma mansoni vesicular amine transporter 0.001 0.0007 0.0033
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.003 0.0059 0.0272

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1.451 uM PUBCHEM_BIOASSAY: TRFRET-based biochemical high throughput dose response assay for inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 66 uM PUBCHEM_BIOASSAY: Dose-response secondary confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay using Cy5 labeled peptide. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 66 uM PUBCHEM_BIOASSAY: Dose-response confirmation of microRNA-mediated mRNA deacetylation inhibitors by fluorescence polarization assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (binding) 7.0795 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 19.9526 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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