Detailed information for compound 1409497

Basic information

Technical information
  • TDR Targets ID: 1409497
  • Name: N-phenyl-3-piperidin-1-ylpropanamide
  • MW: 232.321 | Formula: C14H20N2O
  • H donors: 1 H acceptors: 1 LogP: 1.91 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccccc1)CCN1CCCCC1
  • InChi: 1S/C14H20N2O/c17-14(15-13-7-3-1-4-8-13)9-12-16-10-5-2-6-11-16/h1,3-4,7-8H,2,5-6,9-12H2,(H,15,17)
  • InChiKey: VQQGOXHLQOBMRC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-phenyl-3-(1-piperidyl)propanamide
  • N-phenyl-3-piperidino-propionamide
  • N-phenyl-3-piperidin-1-yl-propanamide
  • Oprea1_335118
  • Oprea1_453655
  • BAS 03086441
  • N-Phenyl-3-piperidin-1-yl-propionamide
  • ST5015776
  • MLS000710444
  • SMR000280211

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0031 0.0036
Echinococcus granulosus alpha 1A adrenergic receptor 0.0055 0.1956 0.4219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0742 0.0646
Brugia malayi RE15519p 0.0055 0.1956 0.2211
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Schistosoma mansoni neuropeptide receptor 0.0055 0.1956 0.4219
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.1956 0.4219
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0031 0.0936 0.1754
Schistosoma mansoni amine GPCR 0.0055 0.1956 0.4219
Leishmania major 4-coumarate:coa ligase-like protein 0.0053 0.1863 0.374
Brugia malayi hypothetical protein 0.0055 0.1956 0.2211
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0031 0.0936 0.1577
Brugia malayi G-protein coupled receptor 0.0055 0.1956 0.2211
Loa Loa (eye worm) hypothetical protein 0.004 0.1286 0.1472
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0031 0.0936 0.1577
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0055 0.1956 0.4219
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.2265 0.2593
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0031 0.0936 0.1754
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0016 0.0251 0.021
Trichomonas vaginalis antibiotic synthetase, putative 0.0016 0.0251 0.015
Echinococcus multilocularis 0.0031 0.0936 0.1982
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.1524 0.7896
Leishmania major acetyl-CoA synthetase, putative 0.0016 0.0251 0.0042
Giardia lamblia GTOR 0.0045 0.1524 1
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0031 0.0036
Brugia malayi Cytochrome P450 family protein 0.0031 0.0936 0.1039
Onchocerca volvulus 0.0055 0.1956 0.193
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.1742 0.375
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2265 0.4897
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.1956 0.4219
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0031 0.0936 0.1577
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0055 0.1956 0.4219
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0116 0.4592 1
Brugia malayi hypothetical protein 0.0055 0.1956 0.2211
Echinococcus multilocularis g-protein coupled receptor 0.0055 0.1956 0.4219
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.1956 0.4219
Brugia malayi Serotonin receptor 0.0055 0.1956 0.2211
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.1524 0.1715
Mycobacterium ulcerans acyl-CoA synthetase 0.0053 0.1863 0.3714
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0116 0.4592 1
Echinococcus multilocularis neuropeptide s receptor 0.0055 0.1956 0.4219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.124 0.1149
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0251 0.0252
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.1128 0.2054
Schistosoma mansoni opsin-like receptor 0.0055 0.1956 0.4219
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0031 0.0936 0.1754
Loa Loa (eye worm) cytochrome P450 family protein 0.0041 0.1355 0.1551
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0232 0.0266
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.1742 0.1965
Trypanosoma cruzi cytochrome P450, putative 0.0041 0.1355 0.2575
Onchocerca volvulus 0.0055 0.1956 0.193
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0016 0.0251 0.0252
Onchocerca volvulus 0.0055 0.1956 0.193
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0053 0.1863 0.3714
Leishmania major cytochrome p450-like protein 0.0031 0.0936 0.1613
Echinococcus multilocularis somatostatin receptor 0.0055 0.1956 0.4219
Onchocerca volvulus Neuropeptide F receptor homolog 0.0055 0.1956 0.193
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0707 0.0809
Loa Loa (eye worm) hypothetical protein 0.004 0.1286 0.1472
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0031 0.0936 0.1577
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0251 0.0252
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Mycobacterium ulcerans hypothetical protein 0.0053 0.1863 0.3714
Onchocerca volvulus 0.003 0.0894 0.0865
Brugia malayi Pre-SET motif family protein 0.003 0.0894 0.0991
Schistosoma mansoni amine GPCR 0.0055 0.1956 0.4219
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.1956 0.4219
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0894 0.1481
Echinococcus multilocularis G protein coupled receptor 139 0.0055 0.1956 0.4219
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0707 0.0611
Schistosoma mansoni amine GPCR 0.0055 0.1956 0.4219
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.1956 0.4219
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0051 0.1795 0.3557
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0016 0.0251 0.021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0628 0.0532
Onchocerca volvulus 0.0016 0.0251 0.022
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0055 0.1956 0.4219
Onchocerca volvulus 0.0055 0.1956 0.193
Schistosoma mansoni hypothetical protein 0.0055 0.1956 0.4219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.063 0.0533
Toxoplasma gondii cytochrome p450 superfamily protein 0.0031 0.0936 0.1577
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0707 0.1088
Echinococcus granulosus G protein coupled receptor 139 0.0055 0.1956 0.4219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.1524 0.1436
Onchocerca volvulus 0.0055 0.1956 0.193
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.1524 0.7896
Mycobacterium leprae Conserved hypothetical protein 0.0031 0.0936 0.1577
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0232 0.0132
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.1956 0.4219
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0055 0.1956 0.4219
Schistosoma mansoni neuropeptide receptor 0.0055 0.1956 0.4219
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0031 0.0936 0.1754
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0031 0.0936 0.1577
Brugia malayi Pre-SET motif family protein 0.0212 0.8735 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.1026 0.0933
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0055 0.1956 0.4219
Loa Loa (eye worm) IMP dehydrogenase 1 0.0116 0.4592 0.5257
Loa Loa (eye worm) melatonin receptor type 1A 0.0055 0.1956 0.2239
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.1956 0.4219
Brugia malayi AMP-binding enzyme family protein 0.0053 0.1863 0.2104
Loa Loa (eye worm) hypothetical protein 0.0053 0.1863 0.2133
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0116 0.4592 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0232 0.0132
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0055 0.1956 0.2239
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.1956 0.4219
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0036
Echinococcus multilocularis neuropeptide receptor A26 0.0055 0.1956 0.4219
Loa Loa (eye worm) oxidoreductase 0.0016 0.0251 0.0287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0742 0.0646
Onchocerca volvulus Putative GMP reductase 0.0051 0.1795 0.1769
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0055 0.1956 0.2211
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0031 0.0036
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.1524 0.3272
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Schistosoma mansoni neuropeptide receptor 0.0055 0.1956 0.4219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.063 0.0533
Echinococcus granulosus flap endonuclease 1 0.0026 0.0707 0.1481
Trypanosoma cruzi cytochrome P450, putative 0.0041 0.1355 0.2575
Leishmania major 4-coumarate:coa ligase-like protein 0.0053 0.1863 0.374
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.1524 0.1436
Schistosoma mansoni neuropeptide receptor 0.0055 0.1956 0.4219
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0031 0.0936 0.1577
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.1742 0.375
Brugia malayi hypothetical protein 0.0055 0.1956 0.2211
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0036
Echinococcus granulosus serotonin receptor 0.0055 0.1956 0.4219
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0041 0.1355 0.2543
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0031 0.0936 0.1577
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.1524 0.3272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.063 0.0533
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0031 0.0936 0.1613
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.073 0.0635
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0031 0.0936 0.1577
Entamoeba histolytica acyl-CoA synthetase, putative 0.0053 0.1863 1
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.1956 0.4219
Loa Loa (eye worm) hypothetical protein 0.004 0.1286 0.1472
Brugia malayi neuropeptide F receptor 0.0055 0.1956 0.2211
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.05 0.0613
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.004 0.1286 0.2545
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0031 0.0936 0.1577
Echinococcus granulosus 7TM GPCR rhodopsin 0.0055 0.1956 0.4219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.1026 0.0933
Brugia malayi hypothetical protein 0.0055 0.1956 0.2211
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0031 0.0036
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0051 0.1795 0.3557
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0031 0.0936 0.1754
Onchocerca volvulus 0.0055 0.1956 0.193
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0065 0.2378 0.49
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0031 0.0936 0.1577
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0031 0.0036
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.1956 0.4219
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0116 0.4592 0.5
Leishmania major cytochrome p450-like protein 0.0041 0.1355 0.2575
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.1126 0.1035
Loa Loa (eye worm) hypothetical protein 0.0053 0.1863 0.2133
Echinococcus multilocularis G-protein coupled receptor, putative 0.0055 0.1956 0.4219
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.1956 0.4219
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.1193 0.2335
Schistosoma mansoni biogenic amine (5HT) receptor 0.0055 0.1956 0.4219
Echinococcus granulosus neuropeptide receptor A26 0.0055 0.1956 0.4219
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.1742 0.1994
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0116 0.4592 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0055 0.1956 0.4219
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0055 0.1956 0.4219
Echinococcus multilocularis neuropeptide FF receptor 2 0.0055 0.1956 0.4219
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0051 0.1795 0.2026
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0053 0.1863 0.3714
Trypanosoma cruzi GMP reductase 0.0116 0.4592 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0016 0.0251 0.021
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0031 0.0936 0.1754
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Brugia malayi G-protein coupled receptor 0.0055 0.1956 0.2211
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0051 0.1795 0.2026
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.1524 0.2962
Schistosoma mansoni opsin-like receptor 0.0055 0.1956 0.4219
Schistosoma mansoni opsin-like receptor 0.0055 0.1956 0.4219
Brugia malayi putative neuropeptide receptor 0.0055 0.1956 0.2211
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0707 0.105
Echinococcus granulosus tachykinin peptides receptor 99D 0.0055 0.1956 0.4219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0628 0.0532
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0232 0.0231
Onchocerca volvulus 0.0055 0.1956 0.193
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0251 0.021
Schistosoma mansoni biogenic amine receptor 0.0055 0.1956 0.4219
Brugia malayi TAR-binding protein 0.0062 0.2265 0.2566
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.073 0.0635
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.1524 0.2962
Schistosoma mansoni growth hormone secretagogue receptor 0.0055 0.1956 0.4219
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0031 0.0036
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.1956 0.2239
Brugia malayi larval opioid receptor 0.0055 0.1956 0.2211
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0232 0.0132
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0116 0.4592 0.524
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0894 0.1891
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.1956 0.4219
Onchocerca volvulus 0.0055 0.1956 0.193
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.1956 0.4219
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Plasmodium falciparum acyl-CoA synthetase 0.004 0.1286 0.2385
Mycobacterium ulcerans fatty-acid-CoA ligase 0.004 0.1286 0.2385
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0031 0.0936 0.1577
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.1956 0.4219
Loa Loa (eye worm) hypothetical protein 0.0016 0.0251 0.0287
Schistosoma mansoni biogenic amine receptor 0.0055 0.1956 0.4219
Echinococcus granulosus neuropeptide receptor 0.0055 0.1956 0.4219
Schistosoma mansoni hypothetical protein 0.0055 0.1956 0.4219
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.1956 0.4219
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0016 0.0251 0.0042
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0116 0.4592 1
Echinococcus multilocularis orexin receptor type 2 0.0055 0.1956 0.4219
Brugia malayi G protein-coupled receptor 0.0055 0.1956 0.2211
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0707 0.105
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.1742 0.375
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0065 0.2378 0.5007
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0031 0.0936 0.1754
Brugia malayi Tachykinin-like peptides receptor 99D 0.0055 0.1956 0.2211
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0031 0.0036
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0016 0.0251 0.021
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.1742 0.375
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.8735 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0055 0.1956 0.4219
Brugia malayi AKH receptor 0.0055 0.1956 0.2211
Trichomonas vaginalis set domain proteins, putative 0.0242 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.1956 0.4219
Brugia malayi hypothetical protein 0.0055 0.1956 0.2211
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.1742 0.375
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0055 0.1956 0.2211
Onchocerca volvulus 0.0055 0.1956 0.193
Brugia malayi Flap endonuclease-1 0.0026 0.0707 0.0776
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.1026 0.0933
Schistosoma mansoni biogenic amine (5HT) receptor 0.0055 0.1956 0.4219
Brugia malayi Dopamine receptor protein 1 0.0055 0.1956 0.2211
Brugia malayi hypothetical protein 0.0055 0.1956 0.2211
Echinococcus granulosus orexin receptor type 2 0.0055 0.1956 0.4219
Echinococcus multilocularis neuropeptide receptor 0.0055 0.1956 0.4219
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0031 0.0936 0.1613
Trichomonas vaginalis antibiotic synthetase, putative 0.0016 0.0251 0.015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0742 0.0646
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0116 0.4592 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2265 0.4897
Brugia malayi putative neuropeptide receptor NPR1 0.0055 0.1956 0.2211
Schistosoma mansoni hypothetical protein 0.0031 0.0936 0.1982
Echinococcus multilocularis g protein coupled receptor 0.0055 0.1956 0.4219
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0055 0.1956 0.4219
Brugia malayi follicle stimulating hormone receptor 0.0055 0.1956 0.2211
Loa Loa (eye worm) hypothetical protein 0.004 0.1286 0.1472
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.1524 0.1436
Schistosoma mansoni neuropeptide f receptor 76f 0.0055 0.1956 0.4219
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0016 0.0251 0.021
Schistosoma mansoni amine GPCR 0.0055 0.1956 0.4219
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0036
Brugia malayi Serotonin receptor 0.0055 0.1956 0.2211
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0232 0.0441
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.1524 0.2962
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.1956 0.4219
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.1956 0.4219
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.1956 0.4219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.1026 0.0933
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0842 0.0748
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Echinococcus granulosus dro:myosuppressin receptor 0.0055 0.1956 0.4219
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Echinococcus granulosus g protein coupled receptor 0.0055 0.1956 0.4219
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2265 0.4897
Brugia malayi sulfakinin receptor protein 0.0055 0.1956 0.2211
Loa Loa (eye worm) GMP reductase 0.0051 0.1795 0.2055
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.1956 0.4219
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0031 0.0936 0.1754
Schistosoma mansoni histamine h1 receptor 0.0055 0.1956 0.4219
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0031 0.0936 0.1754
Echinococcus multilocularis dro:myosuppressin receptor 0.0055 0.1956 0.4219
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0053 0.1863 0.3714
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.1193 0.2335
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.1956 0.4219
Schistosoma mansoni adenoreceptor 0.0055 0.1956 0.4219
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0894 0.1891
Echinococcus multilocularis neuropeptide Y receptor 0.0055 0.1956 0.4219
Mycobacterium ulcerans acyl-CoA synthetase 0.0053 0.1863 0.3714
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0232 0.0132
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0016 0.0251 0.0481
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0055 0.1956 0.4219
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0388 0.0357
Brugia malayi hypothetical protein 0.0055 0.1956 0.2211
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0016 0.0251 0.0042
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0016 0.0251 0.0481
Entamoeba histolytica acyl-CoA synthetase, putative 0.0053 0.1863 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.1128 0.2054
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0016 0.0251 0.021
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.1742 0.375
Leishmania major guanosine monophosphate reductase 0.0116 0.4592 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0041 0.1355 0.1551
Echinococcus granulosus g protein coupled receptor 0.0055 0.1956 0.4219
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0031 0.0936 0.1754
Echinococcus granulosus g-protein coupled receptor 0.0055 0.1956 0.4219
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0031 0.0936 0.1754
Plasmodium vivax acyl-CoA synthetase, putative 0.004 0.1286 0.2385
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0116 0.4592 1
Onchocerca volvulus 0.0055 0.1956 0.193
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.1524 0.2962
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0055 0.1956 0.2211
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0031 0.0936 0.1577
Trypanosoma brucei cytochrome P450, putative 0.0041 0.1355 0.2575
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0031 0.0936 0.1577
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.1026 0.0933
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.1863 0.3714
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.1193 0.2335
Onchocerca volvulus 0.0055 0.1956 0.193
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0232 0.0132
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0031 0.0936 0.1577
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Echinococcus granulosus neuropeptide receptor 0.0055 0.1956 0.4219
Echinococcus granulosus neuropeptide Y receptor 0.0055 0.1956 0.4219
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0055 0.1956 0.4219
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0707 0.1481
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0031 0.0936 0.1613
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0031 0.0936 0.1754
Plasmodium falciparum flap endonuclease 1 0.0026 0.0707 0.105
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.1126 0.1035
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0055 0.1956 0.4219
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0116 0.4592 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.1524 0.3272
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Loa Loa (eye worm) cytochrome P450 0.0031 0.0936 0.1071
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Brugia malayi AMP-binding enzyme family protein 0.0053 0.1863 0.2104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0628 0.0532
Mycobacterium ulcerans acyl-CoA synthetase 0.0053 0.1863 0.3714
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.1956 0.4219
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0031 0.0936 0.1754
Echinococcus granulosus neuropeptides capa receptor 0.0055 0.1956 0.4219
Brugia malayi hypothetical protein 0.0055 0.1956 0.2211
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0055 0.1956 0.4219
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.2265 0.2566
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0036
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0053 0.1863 0.3714
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0845 0.1785
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0031 0.0936 0.1577
Echinococcus multilocularis neuropeptide Y receptor 0.0055 0.1956 0.4219
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0016 0.0251 0.0042
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0055 0.1956 0.4219
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0055 0.1956 0.4219
Echinococcus multilocularis serotonin receptor 0.0055 0.1956 0.4219
Leishmania major inosine-5-monophosphate dehydrogenase 0.0116 0.4592 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0116 0.4588 0.5253
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0055 0.1956 0.2239
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0031 0.0936 0.1577
Entamoeba histolytica acyl-coA synthetase, putative 0.0053 0.1863 1
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0016 0.0251 0.0042
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0116 0.4592 1
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0031 0.0936 0.1754
Onchocerca volvulus 0.0055 0.1956 0.193
Brugia malayi Dopamine receptor protein 2 0.0055 0.1956 0.2211
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0116 0.4592 1
Echinococcus granulosus cytochrome P450 2K1 0.0031 0.0936 0.1982
Onchocerca volvulus 0.0053 0.1863 0.1837
Loa Loa (eye worm) RNA binding protein 0.0062 0.2265 0.2593
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.1956 0.4219
Echinococcus granulosus fmrfamide receptor 0.0055 0.1956 0.4219
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Brugia malayi Melatonin receptor type 1A 0.0055 0.1956 0.2211
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.1956 0.4219
Echinococcus multilocularis fmrfamide receptor 0.0055 0.1956 0.4219
Echinococcus granulosus neuropeptide s receptor 0.0055 0.1956 0.4219
Loa Loa (eye worm) CYP4Cod1 0.0041 0.1355 0.1551
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0707 0.1088
Loa Loa (eye worm) hypothetical protein 0.003 0.0894 0.1023
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0055 0.1956 0.2211
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.1524 0.1745
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.004 0.1286 0.5
Onchocerca volvulus 0.0016 0.0251 0.022
Echinococcus multilocularis tar DNA binding protein 0.0062 0.2265 0.4897
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0031 0.0936 0.1754
Echinococcus granulosus g protein coupled receptor 0.0055 0.1956 0.4219
Brugia malayi cytochrome P450 0.0031 0.0936 0.1039
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0031 0.0936 0.1577
Schistosoma mansoni myosin xvIII 0.0055 0.1956 0.4219
Echinococcus granulosus 7tm_1 domain containing protein 0.0055 0.1956 0.4219
Toxoplasma gondii IMP dehydrogenas 0.0116 0.4592 1
Echinococcus multilocularis neuropeptides capa receptor 0.0055 0.1956 0.4219
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0894 0.1891
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0055 0.1956 0.4219
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0031 0.0936 0.1754
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.1956 0.4219
Brugia malayi RNA binding protein 0.0062 0.2265 0.2566
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.1126 0.1035
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.1956 0.4219
Echinococcus multilocularis serotonin receptor 0.0055 0.1956 0.4219
Echinococcus multilocularis sex peptide receptor 0.0055 0.1956 0.4219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.1026 0.0933
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0116 0.4592 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0055 0.1956 0.4219
Leishmania major cytochrome p450-like protein 0.0031 0.0936 0.1613
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.1956 0.2239
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0055 0.1956 0.4219
Brugia malayi AMP-binding enzyme family protein 0.0053 0.1863 0.2104
Onchocerca volvulus 0.0055 0.1956 0.193
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0232 0.0441
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0031 0.0036
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0055 0.1956 0.2239
Schistosoma mansoni hypothetical protein 0.0055 0.1956 0.4219
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0036
Echinococcus multilocularis g protein coupled receptor 0.0055 0.1956 0.4219
Echinococcus granulosus biogenic amine 5HT receptor 0.0055 0.1956 0.4219
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.1524 0.2962
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0894 0.1891
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.1956 0.4219
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0031 0.0936 0.1754
Mycobacterium leprae putative cytochrome p450 0.0031 0.0936 0.1577
Brugia malayi GMP reductase 0.0051 0.1795 0.2026
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0055 0.1956 0.2211
Brugia malayi Cytochrome P450 family protein 0.0116 0.4588 0.5236
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0016 0.0251 0.0287
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.1956 0.4219
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0251 0.021
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0016 0.0251 0.0042
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0055 0.1956 0.4219
Onchocerca volvulus 0.0055 0.1956 0.193
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0055 0.1956 0.4219
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0053 0.1863 0.3714
Echinococcus multilocularis g protein coupled receptor 0.0055 0.1956 0.4219
Echinococcus granulosus neuropeptide Y receptor 0.0055 0.1956 0.4219
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0016 0.0251 0.021
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0116 0.4592 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.063 0.0533
Loa Loa (eye worm) hypothetical protein 0.004 0.1286 0.1472
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0251 0.0252
Brugia malayi neuropeptide F receptor 0.0055 0.1956 0.2211
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0036
Echinococcus granulosus sex peptide receptor 0.0055 0.1956 0.4219
Onchocerca volvulus 0.0016 0.0251 0.022
Onchocerca volvulus 0.0055 0.1956 0.193
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.1956 0.4219
Trypanosoma brucei GMP reductase 0.0116 0.4592 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0016 0.0251 0.0287
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.1193 0.2335
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.1956 0.4219
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.1956 0.4219
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0031 0.0936 0.1754
Trypanosoma cruzi GMP reductase 0.0116 0.4592 1
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0251 0.0252
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0031 0.0936 0.1577
Loa Loa (eye worm) TAR-binding protein 0.0062 0.2265 0.2593
Schistosoma mansoni biogenic amine receptor 0.0055 0.1956 0.4219
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.1956 0.2239
Schistosoma mansoni flap endonuclease-1 0.0024 0.0599 0.1243
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.1956 0.4219
Echinococcus granulosus somatostatin receptor 0.0055 0.1956 0.4219
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Brugia malayi G protein-coupled receptor F59B2.13 0.0055 0.1956 0.2211
Loa Loa (eye worm) TYRA-2 protein 0.0055 0.1956 0.2239
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0055 0.1956 0.4219
Echinococcus granulosus neuropeptides capa receptor 0.0055 0.1956 0.4219
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0031 0.0936 0.1754
Loa Loa (eye worm) hypothetical protein 0.0016 0.0251 0.0287
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.1956 0.4219
Echinococcus multilocularis allatostatin A receptor 0.0055 0.1956 0.4219
Echinococcus granulosus allatostatin A receptor 0.0055 0.1956 0.4219
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0116 0.4592 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0053 0.1863 0.3846
Brugia malayi Dopamine receptor 0.0055 0.1956 0.2211
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Brugia malayi GnHR receptor homolog 0.0055 0.1956 0.2211
Loa Loa (eye worm) hypothetical protein 0.0053 0.1863 0.2133
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0031 0.0936 0.1577
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.1026 0.1785
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.1956 0.4219
Onchocerca volvulus 0.0016 0.0251 0.022
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0031 0.0936 0.1613
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0894 0.1891
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0055 0.1956 0.193
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0055 0.1956 0.4219
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.1128 0.2054
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0055 0.1956 0.2239
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0055 0.1956 0.2239
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0031 0.0936 0.1754
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0016 0.0251 0.0042
Leishmania major acetyl-CoA synthetase, putative 0.0016 0.0251 0.0042
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Leishmania major 4-coumarate:coa ligase-like protein 0.0053 0.1863 0.374
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0894 0.1891
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.1126 0.1035
Echinococcus granulosus neuropeptide FF receptor 2 0.0055 0.1956 0.4219
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.1956 0.4219
Schistosoma mansoni cytochrome P450 0.0031 0.0936 0.1982
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0251 0.021
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0055 0.1956 0.4219
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0707 0.1088
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.1126 0.1035
Onchocerca volvulus 0.0055 0.1956 0.193
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0055 0.1956 0.4219
Onchocerca volvulus 0.0055 0.1956 0.193
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.1956 0.4219
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0031 0.0936 0.1577
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0894 0.1891
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.1742 0.375
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0707 0.2828
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.1956 0.2239
Brugia malayi Cytochrome P450 family protein 0.0041 0.1355 0.1521
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Plasmodium vivax SET domain protein, putative 0.003 0.0894 0.1481
Schistosoma mansoni acetyl-CoA synthetase 0.0016 0.0251 0.0481
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0251 0.021
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0251 0.0252
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0055 0.1956 0.4219
Echinococcus multilocularis neuropeptide receptor 0.0055 0.1956 0.4219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.1026 0.0933
Echinococcus granulosus hypothetical protein 0.0055 0.1956 0.4219
Echinococcus granulosus tar DNA binding protein 0.0062 0.2265 0.4897
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0016 0.0251 0.0042
Brugia malayi ORL1-like opioid receptor 0.0055 0.1956 0.2211
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0884 0.079
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2265 0.4897
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.1863 0.3846
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0031 0.0936 0.1613
Echinococcus granulosus peptide allatostatin:somatostatin 0.0055 0.1956 0.4219
Schistosoma mansoni amine GPCR 0.0055 0.1956 0.4219
Brugia malayi hypothetical protein 0.0055 0.1956 0.2211
Brugia malayi Cytochrome P450 family protein 0.0041 0.1355 0.1521
Brugia malayi hypothetical protein 0.0055 0.1956 0.2211
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.1524 0.2962
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0055 0.1956 0.4219
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.1956 0.4219
Echinococcus multilocularis fmrfamide receptor 0.0055 0.1956 0.4219
Schistosoma mansoni hypothetical protein 0.0055 0.1956 0.4219
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239
Echinococcus multilocularis neuropeptides capa receptor 0.0055 0.1956 0.4219
Echinococcus granulosus biogenic amine 5HT receptor 0.0055 0.1956 0.4219
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0232 0.0441
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2265 0.4897
Loa Loa (eye worm) hypothetical protein 0.0055 0.1956 0.2239

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0019 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 63.0957 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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