Detailed information for compound 1412825

Basic information

Technical information
  • TDR Targets ID: 1412825
  • Name: 1-hydroxy-2-(4-morpholin-4-ylsulfonylphenyl)- 4H-1,2,4-benzotriazin-3-one
  • MW: 390.414 | Formula: C17H18N4O5S
  • H donors: 2 H acceptors: 4 LogP: 1.04 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1[nH]c2ccccc2n(n1c1ccc(cc1)S(=O)(=O)N1CCOCC1)O
  • InChi: 1S/C17H18N4O5S/c22-17-18-15-3-1-2-4-16(15)21(23)20(17)13-5-7-14(8-6-13)27(24,25)19-9-11-26-12-10-19/h1-8,23H,9-12H2,(H,18,22)
  • InChiKey: DSTBDSBKYGCGNP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-hydroxy-2-(4-morpholinosulfonylphenyl)-4H-1,2,4-benzotriazin-3-one
  • 1-hydroxy-2-[4-(morpholin-4-ylsulfonyl)phenyl]-1,4-dihydro-1,2,4-benzotriazin-3(2H)-one
  • MLS000586465
  • SMR000207844

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0093 0.0072
Brugia malayi Steroid receptor seven-up type 2 0.0029 0.0261 0.0261
Loa Loa (eye worm) hypothetical protein 0.0027 0.0222 0.0202
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0571 0.0551
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0093 0.0041
Brugia malayi nuclear receptor RXR 0.0014 0.0021 0.0021
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0149 0.0205
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0026
Loa Loa (eye worm) hypothetical protein 0.0029 0.0261 0.024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.007 0.0018
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0931 0.1245
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0383 0.0363
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0261 0.0261
Leishmania major trypanothione reductase 0.0049 0.0565 0.0516
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0169 0.0148
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0661 1 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.007 0.0034
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0093 0.0474
Loa Loa (eye worm) hypothetical protein 0.0028 0.0239 0.0218
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0073 0.0938 0.0891
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0074 0.0941 0.0922
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0129 0.12
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0424 0.364
Brugia malayi nuclear receptor NHR-88 0.0014 0.0021 0.0021
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0424 1
Brugia malayi Bromodomain containing protein 0.004 0.0421 0.0421
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0931 0.222
Schistosoma mansoni hypothetical protein 0.0016 0.0052 0.0031
Onchocerca volvulus 0.0058 0.0702 0.1898
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0261 0.024
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0571 0.0551
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0661 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0222 0.0202
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0565 0.5904
Schistosoma mansoni thyroid hormone receptor 0.0161 0.2281 0.2264
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0029 0.0261 0.024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0571 0.0551
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0112 0.1537 0.8592
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0129 0.0691
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0047 0.0026
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0129 0.0153
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0093 0.0072
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0565 0.0545
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0093 0.0615
Loa Loa (eye worm) hypothetical protein 0.0029 0.0261 0.024
Leishmania major hypothetical protein, conserved 0.0073 0.0931 0.0883
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0093 0.0041
Echinococcus granulosus intermediate filament protein 0.0058 0.0702 0.0682
Echinococcus granulosus geminin 0.0365 0.543 0.542
Mycobacterium tuberculosis Probable dehydrogenase 0.0112 0.1537 0.2121
Schistosoma mansoni RAR-like nuclear receptor 0.0029 0.0261 0.024
Echinococcus granulosus bloom syndrome protein 0.0022 0.0149 0.0128
Toxoplasma gondii exonuclease III APE 0.0021 0.0129 0.0094
Brugia malayi intermediate filament protein 0.0058 0.0702 0.0702
Schistosoma mansoni hypothetical protein 0.0131 0.1826 0.1809
Trichomonas vaginalis esterase, putative 0.0073 0.0931 0.222
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0129 0.0077
Echinococcus multilocularis lamin 0.0058 0.0702 0.0682
Schistosoma mansoni hypothetical protein 0.0365 0.543 0.542
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0559 0.0539
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.007 0.0018
Echinococcus multilocularis thyroid hormone receptor alpha 0.0161 0.2281 0.2264
Loa Loa (eye worm) hypothetical protein 0.0049 0.0559 0.0539
Brugia malayi hypothetical protein 0.0178 0.2546 0.2546
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0093 0.0041
Schistosoma mansoni steroid hormone receptor ad4bp 0.0029 0.0261 0.024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0029 0.0261 0.024
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0129 0.0153
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.395 1
Brugia malayi conserved hypotetical protein 0.0014 0.0021 0.0021
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.007 0.0018
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0931 0.0931
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0462 0.0442
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.008 0.0059
Mycobacterium ulcerans hypothetical protein 0.0073 0.0931 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.008 0.0059
Onchocerca volvulus 0.0073 0.0931 0.2538
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0565 0.0716
Schistosoma mansoni bromodomain containing protein 0.0066 0.0822 0.0803
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0029 0.0261 0.024
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0462 0.0442
Brugia malayi Cytochrome P450 family protein 0.0023 0.0162 0.0162
Echinococcus multilocularis geminin 0.0365 0.543 0.542
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0108 0.0764
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0661 1 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.008 0.0059
Loa Loa (eye worm) hypothetical protein 0.0029 0.0261 0.024
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.007 0.5
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0026
Schistosoma mansoni hypothetical protein 0.0021 0.0138 0.0117
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0424 0.0373
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.395 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0029 0.0261 0.024
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0931 0.222
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0029 0.0261 0.024
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0093 0.0034
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0261 0.024
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0246 0.3597 0.3564
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0021 0.0021
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.007 0.0018
Onchocerca volvulus 0.0031 0.0286 0.0738
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.2525 0.6328
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0931 0.0883
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0931 0.0912
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.395 1
Loa Loa (eye worm) steroid hormone receptor 0.0029 0.0261 0.024
Plasmodium vivax SET domain protein, putative 0.0031 0.0286 0.2772
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0246 0.3601 0.3588
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0129 0.0108
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0093 0.0072
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0424 0.0912
Loa Loa (eye worm) hypothetical protein 0.0029 0.0261 0.024
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0286 0.0265
Loa Loa (eye worm) hypothetical protein 0.0029 0.0261 0.024
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0931 0.0912
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0029 0.0261 0.024
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0765 0.0745
Brugia malayi hypothetical protein 0.0016 0.0047 0.0047
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0565 0.0545
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0938 0.0891
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0931 0.1245
Onchocerca volvulus 0.0178 0.2546 0.7041
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0047 0.0026
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0931 0.1245
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.007 0.0018
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0138 0.0117
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0093 0.0072
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.2525 0.6328
Loa Loa (eye worm) hypothetical protein 0.0044 0.0491 0.0471
Loa Loa (eye worm) hypothetical protein 0.0029 0.0261 0.024
Loa Loa (eye worm) hypothetical protein 0.0058 0.0702 0.0682
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0029 0.0261 0.024
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0931 0.0912
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0931 0.1245
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0268 0.0248
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.2525 0.6328
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0112 0.1537 0.2121
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0131 0.1826 0.1809
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0029 0.0261 0.0261
Toxoplasma gondii ABC1 family protein 0.0073 0.0931 0.0899
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0029 0.0261 0.024
Toxoplasma gondii thioredoxin reductase 0.0049 0.0565 0.0532
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0931 0.0883
Brugia malayi nuclear receptor NHR-88 0.0029 0.0261 0.0261
Echinococcus multilocularis ecdysone induced protein 78C 0.0029 0.0261 0.024
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0261 0.024
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0029 0.0261 0.0261
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0931 0.222
Echinococcus multilocularis zinc finger protein 0.002 0.0121 0.01
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0047 0.0026
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.007 0.0018
Brugia malayi ecdysteroid receptor 0.0029 0.0261 0.0261
Loa Loa (eye worm) hypothetical protein 0.0042 0.046 0.044
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0169 0.0148
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0047 0.0047
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0129 0.0108
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0931 1
Brugia malayi hypothetical protein 0.0016 0.0047 0.0047
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0073 0.0938 1
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0261 0.0261
Toxoplasma gondii fructose-bisphospatase II 0.0661 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.007 0.0018
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0931 0.222
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0093 0.0058
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0424 0.0403
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.173 1
Mycobacterium ulcerans beta-lactamase 0.0073 0.0931 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0073 0.0938 0.0919
Loa Loa (eye worm) hypothetical protein 0.0073 0.0931 0.0912
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0261 0.024
Mycobacterium tuberculosis Conserved protein 0.0073 0.0931 0.1245
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0149 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0029 0.0261 0.0261
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.2525 0.6328
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0149 0.0205
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.007 0.0034
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0931 0.0912
Brugia malayi isocitrate dehydrogenase 0.0019 0.0093 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0261 0.0261
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0239 0.0218
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0129 0.0129
Loa Loa (eye worm) intermediate filament protein 0.0058 0.0702 0.0682
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.007 0.0018
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.007 0.0352
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0026
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0093 0.0072
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0169 0.0148
Onchocerca volvulus 0.0073 0.0931 0.2538
Brugia malayi PHD-finger family protein 0.0026 0.0207 0.0207
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0559 0.0539
Echinococcus granulosus zinc finger protein 0.002 0.0121 0.01
Brugia malayi glutathione reductase 0.0049 0.0565 0.0565
Loa Loa (eye worm) hypothetical protein 0.0073 0.0931 0.0912
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.0702 0.0702
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0112 0.1537 0.2121
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0661 1 1
Schistosoma mansoni intermediate filament proteins 0.0058 0.0702 0.0682
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0021 0.0021
Plasmodium falciparum glutathione reductase 0.0049 0.0565 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0571 0.0551
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.007 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0029 0.0261 0.024
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0424 0.411
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.395 1
Brugia malayi ecdysone receptor 0.0014 0.0021 0.0021
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.008 0.0059
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0286 0.0266
Loa Loa (eye worm) beta-lactamase 0.0073 0.0931 0.0912
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0269 0.395 0.395
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0571 0.0571
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.007 0.0049
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.009 0.0069
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0129 0.0077
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0073 0.0938 0.0919
Brugia malayi tailless protein 0.0014 0.0021 0.0021
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0938 0.0891
Toxoplasma gondii fructose-bisphospatase I 0.0246 0.3597 0.3575
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.2525 0.6328
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0073 0.0938 0.0938
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0246 0.3597 0.3575
Echinococcus multilocularis lamin dm0 0.0058 0.0702 0.0682
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0938 0.0891
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0093 0.0072
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0093 0.0058
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0931 0.222
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0029 0.0261 0.024
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0047 0.0026
Brugia malayi beta-lactamase 0.0073 0.0931 0.0931
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0029 0.0261 0.0261
Brugia malayi beta-lactamase family protein 0.0073 0.0931 0.0931
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0424 0.0403
Onchocerca volvulus Glucosylceramidase homolog 0.0176 0.2525 0.6983
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0129 0.0108
Trichomonas vaginalis set domain proteins, putative 0.0247 0.3607 0.9116
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.2525 0.6328
Loa Loa (eye worm) hypothetical protein 0.004 0.0422 0.0402
Schistosoma mansoni ap endonuclease 0.0021 0.0129 0.0108
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0261 0.0261
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0424 0.0912
Schistosoma mansoni zinc finger protein 0.002 0.0121 0.01
Mycobacterium tuberculosis Probable reductase 0.0112 0.1537 0.2121
Schistosoma mansoni ap endonuclease 0.0021 0.0129 0.0108
Brugia malayi beta-lactamase family protein 0.0073 0.0931 0.0931
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0129 0.0077
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0559 0.0539
Onchocerca volvulus Bile acid receptor homolog 0.0029 0.0261 0.0669
Loa Loa (eye worm) hypothetical protein 0.0073 0.0931 0.0912
Loa Loa (eye worm) hypothetical protein 0.0029 0.0261 0.024
Brugia malayi nuclear receptor RXR 0.0016 0.0047 0.0047
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.007 0.0049
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0093 0.0041
Mycobacterium ulcerans lipase LipD 0.0073 0.0931 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0073 0.0931 0.0912
Brugia malayi nuclear hormone receptor 0.0014 0.0021 0.0021
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0261 0.0261
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0149 0.0128
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0029 0.0261 0.024
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0093 0.0093
Brugia malayi Thioredoxin reductase 0.0049 0.0565 0.0565
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0029 0.0261 0.024
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0026
Loa Loa (eye worm) RecQ helicase 0.0022 0.0149 0.0128
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0424 0.0373
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0093 0.0072
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0571 0.0551
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.0702 0.0682
Loa Loa (eye worm) glutathione reductase 0.0049 0.0565 0.0545
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0246 0.3597 0.3564
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0286 0.0265
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0029 0.0261 0.024
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.3146 0.3131
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0246 0.3597 0.3564
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0424 0.0912
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0029 0.0261 0.0261
Brugia malayi hypothetical protein 0.0014 0.0021 0.0021
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0021 0.0021
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0931 0.0912
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.007 0.0352
Schistosoma mansoni hypothetical protein 0.0365 0.543 0.542
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0029 0.0261 0.024
Mycobacterium tuberculosis Conserved protein 0.0073 0.0931 0.1245
Schistosoma mansoni retinoic acid receptor RXR 0.0029 0.0261 0.024
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0383 0.0363
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0129 0.168
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0261 0.0261
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0286 0.0251
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0931 0.1245
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.007 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0029 0.0261 0.024
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0077 0.0056
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.007 0.0018
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0466 0.6989 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0931 0.0912
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0424 0.0373
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0931 0.4171
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0129 0.0086
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0239 0.0218
Loa Loa (eye worm) hypothetical protein 0.0073 0.0931 0.0912
Loa Loa (eye worm) inositol-1 0.004 0.0424 0.0403
Trypanosoma brucei trypanothione reductase 0.0049 0.0565 0.0516
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0931 0.1245
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0047 0.0047
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0931 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.007 0.0018
Brugia malayi photoreceptor-specific nuclear receptor 0.0029 0.0261 0.0261
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.2672 0.6706
Brugia malayi Pre-SET motif family protein 0.0217 0.3146 0.3146
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0286 0.0286
Schistosoma mansoni zinc finger protein 0.0016 0.0052 0.0031
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0424 0.039
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0359 0.0418
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0029 0.0261 0.0261
Mycobacterium tuberculosis Conserved protein 0.0073 0.0931 0.1245
Loa Loa (eye worm) hypothetical protein 0.0029 0.0261 0.024
Onchocerca volvulus 0.0058 0.0702 0.1898
Schistosoma mansoni inositol monophosphatase 0.004 0.0424 0.0403
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0073 0.0938 0.0919
Schistosoma mansoni inositol monophosphatase 0.004 0.0424 0.0403
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.395 1
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0931 1
Echinococcus granulosus FTZ F1 alpha 0.0029 0.0261 0.024
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0571 0.0551
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0269 0.395 0.3937
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0093 0.0041
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.007 0.007
Brugia malayi Inositol-1 0.004 0.0424 0.0424
Brugia malayi nuclear hormone receptor 0.0029 0.0261 0.0261
Echinococcus granulosus ecdysone induced protein 78C 0.0029 0.0261 0.024
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0129 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.007 0.0018
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.173 0.24
Loa Loa (eye worm) hypothetical protein 0.0178 0.2546 0.253
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0029 0.0261 0.024
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.395 1
Echinococcus multilocularis musashi 0.0058 0.0702 0.0682
Brugia malayi hypothetical protein 0.0014 0.0021 0.0021
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.007 0.0018
Schistosoma mansoni hypothetical protein 0.0061 0.0744 0.0725
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.007 0.0018
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0129 0.1018
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0931 0.0883
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0286 0.0265
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0129 1
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0661 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0029 0.0261 0.0261
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0029 0.0261 0.024
Brugia malayi steroid hormone receptor 0.0029 0.0261 0.0261
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0931 0.1245
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.173 0.24
Loa Loa (eye worm) hypothetical protein 0.0057 0.0685 0.0666
Onchocerca volvulus 0.0029 0.0261 0.0669
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0131 0.1826 0.1809
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0029 0.0261 0.024
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0021 0.0021
Brugia malayi follicle stimulating hormone receptor 0.0246 0.3601 0.3601
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0559 0.0539
Brugia malayi Bromodomain containing protein 0.0078 0.101 0.101
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0129 0.0077
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.2672 0.6706
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0565 0.0545
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0571 0.0551
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0261 0.0261
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0261 0.024
Echinococcus multilocularis FTZ F1 alpha 0.0029 0.0261 0.024
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0093 0.0072
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0112 0.1537 0.2121
Brugia malayi Pre-SET motif family protein 0.0031 0.0286 0.0286
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0571 0.0551
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0026
Onchocerca volvulus Protein ultraspiracle homolog 0.0029 0.0261 0.0669
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.007 0.0049
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0661 1 1
Brugia malayi nuclear receptor NHR-67 0.0014 0.0021 0.0021
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0047 0.0026
Schistosoma mansoni coup transcription factor 0.0029 0.0261 0.024
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.173 0.24
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0765 0.0745
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0261 0.024
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0661 1 1
Onchocerca volvulus 0.0247 0.3607 1
Schistosoma mansoni lamin 0.0058 0.0702 0.0682
Schistosoma mansoni thyroid hormone receptor 0.0161 0.2281 0.2264
Onchocerca volvulus 0.0073 0.0931 0.2538
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0029 0.0261 0.0669
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0029 0.0261 0.024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.007 0.0018
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0029 0.0261 0.024
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0162 0.0141
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0424 0.0373
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0073 0.0938 0.0919
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0112 0.1537 0.2121
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0029 0.0261 0.024
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.2525 0.6328
Schistosoma mansoni lamin 0.0058 0.0702 0.0682
Mycobacterium leprae Probable lipase LipE 0.0073 0.0931 0.4171
Plasmodium falciparum thioredoxin reductase 0.0049 0.0565 1
Plasmodium vivax glutathione reductase, putative 0.0049 0.0565 0.5904
Echinococcus granulosus lamin 0.0058 0.0702 0.0682
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0565 0.0516
Leishmania major 0.0661 1 1
Echinococcus granulosus lamin dm0 0.0058 0.0702 0.0682
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.008 0.0059

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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