TDR Targets

Basic information

Technical information

TDR Targets ID: 1414092
Name: 4-[3-(2-nitrophenyl)prop-2-enyl]thiomorpholin e
MW: 264.343 | Formula: C13H16N2O2S
H donors: 0 H acceptors: 2 LogP: 2.65 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: [O-][N+](=O)c1ccccc1/C=C/CN1CCSCC1
InChi: 1S/C13H16N2O2S/c16-15(17)13-6-2-1-4-12(13)5-3-7-14-8-10-18-11-9-14/h1-6H,7-11H2/b5-3+
InChiKey: ZENCZLBDXHWVRN-HWKANZROSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[(E)-3-(2-nitrophenyl)prop-2-enyl]thiomorpholine
4-[3-(2-nitrophenyl)-2-propen-1-yl]thiomorpholine
MLS000974499
SMR000496384
Oprea1_450917

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Giardia intestinalis	Putative fructose-1,6-bisphosphate aldolase	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Escherichia coli	penicillin-binding protein	Starlite/ChEMBL	No references
Homo sapiens	lysine (K)-specific demethylase 4A	Starlite/ChEMBL	No references
Homo sapiens	chromobox homolog 1	Starlite/ChEMBL	No references
Homo sapiens	polymerase (DNA directed) iota	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus granulosus	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948
Schistosoma mansoni	chromobox protein	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Onchocerca volvulus	Heterochromatin protein 1 homolog	Get druggable targets OG5_129545	All targets in OG5_129545
Onchocerca volvulus		Get druggable targets OG5_129545	All targets in OG5_129545
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Treponema pallidum	fructose-bisphosphate aldolase	Get druggable targets OG5_129214	All targets in OG5_129214
Echinococcus granulosus	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Echinococcus multilocularis	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Giardia lamblia	Fructose-bisphosphate aldolase	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Theileria parva	hypothetical protein	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus granulosus	Transcription factor JmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Loa Loa (eye worm)	jmjC domain-containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus multilocularis	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma japonicum	JmjC domain-containing histone demethylation protein 3C, putative	Get druggable targets OG5_127917	All targets in OG5_127917
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma japonicum	Probable JmjC domain-containing histone demethylation protein 3B, putative	Get druggable targets OG5_127917	All targets in OG5_127917
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Loa Loa (eye worm)	heterochromatin protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma mansoni	chromobox protein	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus multilocularis	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127917	All targets in OG5_127917
Brugia malayi	Heterochromatin protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_127917	All targets in OG5_127917
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus granulosus	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	Chromobox protein homolog 5, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Brugia malayi	jmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127917	All targets in OG5_127917
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	Get druggable targets OG5_129214	All targets in OG5_129214
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Candida albicans	fructose-bisphosphate aldolase	Putative fructose-1,6-bisphosphate aldolase	323 aa	358 aa	22.6 %
Mycobacterium ulcerans	fructose-bisphosphate aldolase	Putative fructose-1,6-bisphosphate aldolase	323 aa	361 aa	26.9 %
Candida albicans	fructose-bisphosphate aldolase	Putative fructose-1,6-bisphosphate aldolase	323 aa	358 aa	22.6 %
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	Putative fructose-1,6-bisphosphate aldolase	323 aa	361 aa	25.8 %
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	Putative fructose-1,6-bisphosphate aldolase	323 aa	361 aa	25.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0413	0.0413
Echinococcus multilocularis	caspase 8	0.0057	0.0595	0.0593
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0014	0.0002	0.0002
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0035	0.0299	0.0299
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0002	0.0005
Trypanosoma brucei	heat shock protein, putative	0.0069	0.0771	0.9698
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0115	0.1408	0.1406
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0413	0.0876
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0017	0.0045	0.0043
Trichomonas vaginalis	heat shock protein, putative	0.0055	0.0576	0.1221
Schistosoma mansoni	hypothetical protein	0.0038	0.0343	0.0343
Leishmania major	heat shock protein 83-1	0.0069	0.0771	0.9698
Trichomonas vaginalis	heat shock protein, putative	0.0043	0.04	0.0847
Schistosoma mansoni	chromobox protein	0.0014	0.0002	0.0002
Schistosoma mansoni	hypothetical protein	0.0035	0.0299	0.0299
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0014	0.0002	0.0002
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0014	0.0002	0.0002
Plasmodium falciparum	metacaspase-like protein	0.0057	0.0595	0.7717
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0044	0.0426	0.0426
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0044	0.0419	0.0888
Onchocerca volvulus		0.0051	0.0524	0.1573
Schistosoma mansoni	pyruvate dehydrogenase	0.0014	0.0007	0.0007
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0413	0.0876
Plasmodium vivax	hypothetical protein, conserved	0.0057	0.0595	0.7717
Trypanosoma cruzi	heat shock protein 90, putative	0.0069	0.0771	0.9698
Brugia malayi	intermediate filament protein	0.0029	0.021	0.046
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.0014	0.0007	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0465	0.1019
Echinococcus granulosus	lysine specific demethylase 5A	0.0044	0.0426	0.0424
Trypanosoma cruzi	metacaspase, putative	0.0057	0.0595	0.7484
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1112	0.244
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0055	0.0576	0.0574
Onchocerca volvulus		0.0029	0.021	0.0626
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0066	0.0727	0.0727
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0007	0.0015
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0057	0.0595	0.7717
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0261	0.0259
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0261	0.0261
Loa Loa (eye worm)	tumor suppressor	0.0343	0.4559	1
Echinococcus multilocularis	Chromobox protein 3	0.0014	0.0002	0.000000018465
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0017	0.0045	0.0562
Plasmodium falciparum	heat shock protein 90, putative	0.0028	0.0205	0.2654
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0055	0.0576	0.2595
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0576	0.0574
Entamoeba histolytica	hypothetical protein	0.0038	0.0343	0.0725
Echinococcus multilocularis	protein quaking	0.0029	0.0213	0.0211
Echinococcus multilocularis	lamin dm0	0.0029	0.021	0.0208
Trichomonas vaginalis	sensor histidine kinase, putative	0.0014	0.0007	0.001
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0542	0.1188
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0014	0.0007	0.0089
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0017	0.0045	0.0562
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0576	0.0576
Trypanosoma cruzi	Heat shock protein 83, putative	0.0069	0.0771	0.9698
Brugia malayi	Endoplasmin precursor	0.0069	0.0771	0.1691
Brugia malayi	ImpB/MucB/SamB family protein	0.0044	0.0419	0.0919
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0465	0.0984
Echinococcus multilocularis	expressed protein	0.0036	0.0305	0.0303
Loa Loa (eye worm)	jmjC domain-containing protein	0.0044	0.0426	0.0934
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0055	0.0576	0.1558
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0045	0.0043
Schistosoma mansoni	cpg binding protein	0.0032	0.026	0.026
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0576	0.0576
Brugia malayi	tumor suppressor.	0.0343	0.4559	1
Schistosoma mansoni	chromobox protein	0.0014	0.0002	0.0002
Leishmania major	metacaspase, putative	0.0057	0.0595	0.7484
Schistosoma mansoni	endoplasmin	0.0069	0.0771	0.0771
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0014	0.0007	0.0014
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0419	0.527
Echinococcus granulosus	dna polymerase kappa	0.0044	0.0419	0.0417
Brugia malayi	kinase, mitochondrial precursor	0.0014	0.0007	0.0015
Schistosoma mansoni	hypothetical protein	0.0014	0.0002	0.0002
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0025	0.0054
Echinococcus multilocularis	lamin	0.0029	0.021	0.0208
Loa Loa (eye worm)	TOPoisomerase family member	0.0014	0.0007	0.0015
Trypanosoma cruzi	heat shock protein 85, putative	0.0055	0.0576	0.724
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0014	0.0002	0.0005
Plasmodium vivax	hypothetical protein, conserved	0.0014	0.0002	0.0027
Trypanosoma brucei	DNA topoisomerase II beta, putative	0.0014	0.0007	0.0086
Trypanosoma cruzi	DNA polymerase eta, putative	0.0071	0.0795	1
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0057	0.0595	0.1263
Leishmania major	DNA topoisomerase ii	0.0014	0.0007	0.0086
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0098	0.0205
Plasmodium falciparum	metacaspase 1	0.0057	0.0595	0.7717
Trypanosoma brucei	Heat shock protein 83, putative	0.0069	0.0771	0.9698
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0057	0.0595	0.7717
Trypanosoma brucei	DNA topoisomerase II alpha, putative	0.0014	0.0007	0.0086
Mycobacterium leprae	Probable lipase LipE	0.0043	0.0413	0.1855
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0576	0.1264
Echinococcus multilocularis	chromobox protein 1	0.0084	0.0977	0.0975
Brugia malayi	Heterochromatin protein 1	0.0084	0.0977	0.2142
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0261	0.0259
Leishmania major	heat shock protein 83-1	0.0069	0.0771	0.9698
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0576	0.0576
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.0413	0.188
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0014	0.0007	0.0086
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.0028	0.0205	0.0203
Trichomonas vaginalis	sensory transduction histidine kinase, putative	0.0014	0.0007	0.001
Brugia malayi	hypothetical protein	0.0014	0.0002	0.0005
Giardia lamblia	DINP protein human, muc B family	0.0044	0.0419	0.0892
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0069	0.0771	0.1641
Entamoeba histolytica	hypothetical protein	0.0038	0.0343	0.0725
Mycobacterium ulcerans	two component sensor kinase MprB	0.0014	0.0007	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0299	0.0656
Echinococcus multilocularis	tumor protein p63	0.036	0.48	0.4799
Onchocerca volvulus		0.0053	0.0542	0.1627
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0055	0.0576	0.1225
Schistosoma mansoni	endoplasmin	0.0069	0.0771	0.0771
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0413	0.0876
Toxoplasma gondii	chromodomain helicase DNA binding protein CHD1/SWI2/SNF2	0.0014	0.0002	0.0027
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0036	0.0305	0.0668
Schistosoma mansoni	lamin	0.0029	0.021	0.021
Brugia malayi	CHD4 protein	0.0016	0.0026	0.0058
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0017	0.0054	0.011
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0016	0.0026	0.0026
Schistosoma mansoni	hypothetical protein	0.0051	0.0524	0.0524
Leishmania major	heat shock protein 83-1	0.0069	0.0771	0.9698
Trypanosoma brucei	DNA polymerase kappa, putative	0.003	0.023	0.2898
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0025	0.0054
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0036	0.0305	0.0668
Leishmania major	heat shock protein, putative	0.0028	0.0205	0.2574
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.4699	1
Trypanosoma brucei	DNA polymerase eta, putative	0.0071	0.0795	1
Onchocerca volvulus	Putative DNA topoisomerase 2, mitochondrial	0.0014	0.0007	0.0014
Echinococcus granulosus	caspase 2	0.0057	0.0595	0.0593
Plasmodium vivax	hypothetical protein, conserved	0.0014	0.0002	0.0027
Loa Loa (eye worm)	jmjC domain-containing protein	0.0073	0.0818	0.1794
Schistosoma mansoni	caspase-3 (C14 family)	0.0212	0.2743	0.2743
Schistosoma mansoni	survival motor neuron protein	0.0051	0.0524	0.0524
Echinococcus granulosus	dnaJ subfamily B	0.0436	0.585	0.585
Leishmania major	hypothetical protein, conserved	0.0043	0.0413	0.52
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0413	0.1114
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0044	0.0426	0.0426
Schistosoma mansoni	jumonji domain containing protein	0.0092	0.108	0.108
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	0.0212	0.2743	0.2741
Brugia malayi	beta-lactamase	0.0043	0.0413	0.0907
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0413	0.52
Trypanosoma brucei	heat shock protein, putative	0.0069	0.0771	0.9698
Brugia malayi	hypothetical protein	0.0029	0.0213	0.0468
Entamoeba histolytica	hypothetical protein	0.0038	0.0343	0.0725
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0035	0.0293	0.3684
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0044	0.0419	0.527
Mycobacterium ulcerans	DNA gyrase subunit B	0.0014	0.0007	0.0031
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0014	0.0007	0.0031
Brugia malayi	SET domain containing protein	0.0016	0.0028	0.006
Toxoplasma gondii	DNA topoisomerase 2, putative	0.0014	0.0007	0.0089
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0014	0.0007	0.0005
Leishmania major	developmentally regulated phosphoprotein-like protein	0.0014	0.0007	0.0086
Leishmania major	heat shock protein 83-1	0.0069	0.0771	0.9698
Brugia malayi	F/Y-rich N-terminus family protein	0.0022	0.0116	0.0255
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0172	0.2199	0.6004
Brugia malayi	Bromodomain containing protein	0.0035	0.0299	0.0656
Mycobacterium tuberculosis	Probable lipase LipD	0.0043	0.0413	0.1114
Plasmodium falciparum	DNA topoisomerase VI, b subunit, putative	0.0014	0.0007	0.0089
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0419	0.527
Trichomonas vaginalis	rotamase, putative	0.0035	0.0293	0.0619
Trypanosoma cruzi	metacaspase 5, putative	0.0057	0.0595	0.7484
Echinococcus multilocularis	heat shock protein 90	0.0055	0.0576	0.0574
Schistosoma mansoni	intermediate filament proteins	0.0029	0.021	0.021
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0413	0.0411
Echinococcus multilocularis	heat shock protein	0.0069	0.0771	0.0769
Trichomonas vaginalis	chromobox protein, putative	0.0051	0.0514	0.109
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0014	0.0007	0.0086
Plasmodium vivax	heterochromatin protein 1, putative	0.0014	0.0002	0.0027
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0057	0.0595	0.7717
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0017	0.0047	0.0095
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0051	0.0524	0.1148
Trichomonas vaginalis	DNA polymerase eta, putative	0.0044	0.0419	0.0888
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.4699	1
Brugia malayi	isocitrate dehydrogenase	0.0017	0.0045	0.0098
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0413	0.52
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0595	0.1263
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0002	0.0005
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0419	0.527
Plasmodium falciparum	phd finger protein, putative	0.0035	0.0299	0.3877
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0043	0.0413	0.1114
Onchocerca volvulus		0.0031	0.0235	0.0704
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0014	0.0007	0.5
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0021	0.0098	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0002	0.0005
Echinococcus granulosus	lamin dm0	0.0029	0.021	0.0208
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0353	0.4699	1
Toxoplasma gondii	PHD-finger domain-containing protein	0.0035	0.0299	0.3877
Onchocerca volvulus	Cell death protein 3 homolog	0.0057	0.0595	0.1788
Toxoplasma gondii	PHD-finger domain-containing protein	0.0035	0.0299	0.3877
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0045	0.0562
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0057	0.0595	0.1263
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0017	0.0045	0.0045
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0043	0.0413	0.1114
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0465	0.0984
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0261	0.0261
Echinococcus multilocularis	dna polymerase eta	0.0071	0.0795	0.0793
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0413	0.0907
Schistosoma mansoni	hypothetical protein	0.0029	0.0213	0.0213
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0045	0.0562
Trichomonas vaginalis	two component sensor and regulator histidine kinase bacteria, putative	0.0014	0.0007	0.001
Echinococcus granulosus	caspase 8	0.0057	0.0595	0.0593
Trypanosoma cruzi	heat shock protein 90, putative	0.0041	0.0378	0.4752
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1112	0.244
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0017	0.0045	0.0579
Echinococcus granulosus	chromobox protein 1	0.0084	0.0977	0.0975
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0057	0.0595	0.1263
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0413	0.1114
Brugia malayi	Isocitrate dehydrogenase	0.0017	0.0045	0.0098
Echinococcus granulosus	dna polymerase eta	0.0071	0.0795	0.0793
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0045	0.0043
Mycobacterium ulcerans	two component system membrane associated sensor kinase	0.0014	0.0007	0.0031
Trypanosoma brucei	metacaspase MCA3	0.0057	0.0595	0.7484
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0044	0.0419	0.527
Trichomonas vaginalis	esterase, putative	0.0043	0.0413	0.0876
Echinococcus granulosus	survival motor neuron protein 1	0.0252	0.3303	0.3301
Trypanosoma brucei	unspecified product	0.0044	0.0419	0.527
Trypanosoma cruzi	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative	0.0014	0.0007	0.0086
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0595	0.1263
Trypanosoma brucei	heat shock protein 90, putative	0.0069	0.0771	0.9698
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0576	0.1264
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0045	0.0562
Trypanosoma cruzi	metacaspase 5, putative	0.0057	0.0595	0.7484
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0098	0.0205
Onchocerca volvulus		0.0037	0.0323	0.0969
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0044	0.0419	0.0417
Schistosoma mansoni	cellular tumor antigen P53	0.0053	0.0542	0.0542
Brugia malayi	Temporarily assigned gene name protein 44	0.0029	0.0213	0.0468
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0014	0.0007	0.0089
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0044	0.0419	0.0419
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0035	0.0293	0.0619
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0045	0.0043
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0098	0.0205
Trichomonas vaginalis	heat shock protein, putative	0.0028	0.0205	0.0431
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0413	0.0907
Brugia malayi	Pre-SET motif family protein	0.0032	0.0261	0.0573
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0413	0.5362
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0014	0.0002	0.0027
Trichomonas vaginalis	receptor histidine kinase, putative	0.0014	0.0007	0.001
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0044	0.0419	0.527
Trichomonas vaginalis	chromobox protein, putative	0.0084	0.0977	0.2075
Loa Loa (eye worm)	CHromoDomain protein family member	0.0016	0.0026	0.0058
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0343	0.0341
Schistosoma mansoni	lamin	0.0029	0.021	0.021
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.021	0.046
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0413	0.0413
Trypanosoma brucei	DNA polymerase IV, putative	0.0044	0.0419	0.527
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0413	0.0907
Echinococcus granulosus	Chromobox protein 3	0.0014	0.0002	0.000000018465
Onchocerca volvulus		0.0043	0.0413	0.1241
Trypanosoma brucei	heat shock protein, putative	0.0069	0.0771	0.9698
Plasmodium vivax	metacaspase 1, putative	0.0057	0.0595	0.7717
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0419	0.527
Leishmania major	heat shock protein 83-1	0.0069	0.0771	0.9698
Mycobacterium ulcerans	sensor kinase from two component regulatory system	0.0014	0.0007	0.0031
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0172	0.2199	1
Loa Loa (eye worm)	endoplasmin	0.0069	0.0771	0.1691
Brugia malayi	heat shock protein 90	0.0069	0.0771	0.1691
Echinococcus granulosus	caspase 3 apoptosis cysteine peptidase	0.0212	0.2743	0.2741
Loa Loa (eye worm)	heterochromatin protein 1	0.0084	0.0977	0.2142
Loa Loa (eye worm)	hypothetical protein	0.0029	0.021	0.046
Loa Loa (eye worm)	hypothetical protein	0.006	0.0647	0.142
Echinococcus granulosus	Pyruvate dehydrogenase lipoamide kinase	0.0014	0.0007	0.0005
Mycobacterium ulcerans	hypothetical protein	0.0043	0.0413	0.188
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0413	0.0907
Mycobacterium ulcerans	two component sensory transduction histidine kinase MtrB	0.0014	0.0007	0.0031
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0017	0.0045	0.0098
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0595	0.1263
Brugia malayi	Cell death protein 3 precursor	0.0057	0.0595	0.1305
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0223	0.2893	0.6346
Trypanosoma brucei	heat shock protein 90, putative	0.0069	0.0771	0.9698
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0055	0.0576	0.724
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0035	0.0293	0.3684
Plasmodium vivax	heat shock protein, putative	0.0028	0.0205	0.2654
Schistosoma mansoni	caspase-7 (C14 family)	0.0057	0.0595	0.0595
Plasmodium falciparum	heat shock protein 90, putative	0.0028	0.0205	0.2654
Trypanosoma cruzi	heat shock protein, putative	0.0028	0.0205	0.2574
Leishmania major	heat shock protein 83-1	0.0069	0.0771	0.9698
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.021	0.046
Onchocerca volvulus	Alhambra homolog	0.0035	0.0299	0.0895
Echinococcus granulosus	hypothetical protein	0.0029	0.0213	0.0211
Echinococcus granulosus	protein quaking	0.0029	0.0213	0.0211
Entamoeba histolytica	hypothetical protein	0.0038	0.0343	0.0725
Mycobacterium tuberculosis	Probable hydrolase	0.0043	0.0413	0.1114
Entamoeba histolytica	90 kDa heat shock protein, putative	0.0028	0.0205	0.0431
Trichomonas vaginalis	chromobox protein, putative	0.0051	0.0514	0.109
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0305	0.0644
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0044	0.0419	0.1129
Mycobacterium ulcerans	heat shock protein 90	0.0055	0.0576	0.2618
Leishmania major	heat shock protein 83-1	0.0069	0.0771	0.9698
Echinococcus multilocularis	lysine specific demethylase 5A	0.0043	0.0402	0.04
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.021	0.046
Trichomonas vaginalis	heat shock protein, putative	0.0055	0.0576	0.1221
Echinococcus multilocularis	peregrin	0.0035	0.0299	0.0297
Brugia malayi	Valyl-tRNA synthetase	0.0014	0.0002	0.0005
Loa Loa (eye worm)	PHD-finger family protein	0.0035	0.0299	0.0656
Echinococcus granulosus	caspase	0.0212	0.2743	0.2741
Schistosoma mansoni	heat shock protein	0.0028	0.0205	0.0205
Trypanosoma cruzi	metacaspase, putative	0.0057	0.0595	0.7484
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0057	0.0595	0.1263
Echinococcus granulosus	DNA topoisomerase 2 alpha	0.0014	0.0007	0.0005
Leishmania major	DNA polymerase eta, putative	0.0041	0.0376	0.473
Loa Loa (eye worm)	hypothetical protein	0.0252	0.3303	0.7244
Plasmodium falciparum	heterochromatin protein 1	0.0014	0.0002	0.0027
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0419	0.527
Giardia lamblia	Fructose-bisphosphate aldolase	0.0353	0.4699	1
Giardia lamblia	Pms1-like protein	0.0014	0.0007	0.0015
Mycobacterium ulcerans	lipase LipD	0.0043	0.0413	0.188
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0044	0.0419	0.0919
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0413	0.0907
Giardia lamblia	Grp94/Hsp90	0.0055	0.0576	0.1225
Plasmodium falciparum	DNA topoisomerase 2	0.0014	0.0007	0.0089
Echinococcus multilocularis	caspase 2	0.0057	0.0595	0.0593
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0017	0.0045	0.0104
Mycobacterium ulcerans	two component system response phosphate sensor kinase, PhoR	0.0014	0.0007	0.0031
Onchocerca volvulus		0.0046	0.0452	0.1357
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0235	0.0516
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0419	0.527
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0235	0.0516
Trypanosoma brucei	Metacaspase-4	0.0057	0.0595	0.7484
Trypanosoma cruzi	DNA polymerase eta, putative	0.0041	0.0376	0.473
Trypanosoma cruzi	heat shock protein 85, putative	0.0069	0.0771	0.9698
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0413	0.0907
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0044	0.0419	0.527
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.0004	0.0001
Onchocerca volvulus		0.0253	0.3318	1
Brugia malayi	hypothetical protein	0.0094	0.1112	0.244
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0261	0.0261
Brugia malayi	Probable DNA topoisomerase II	0.0014	0.0007	0.0015
Trichomonas vaginalis	sensory transduction histidine kinase bacterial, putative	0.0014	0.0007	0.001
Echinococcus multilocularis	microtubule associated protein 2	0.0736	1	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0213	0.0468
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0576	0.0574
Onchocerca volvulus	Heat shock protein 75 kDa, mitochondrial homolog	0.0028	0.0205	0.0611
Trichomonas vaginalis	heat shock protein, putative	0.0069	0.0771	0.1637
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0014	0.0002	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0595	0.1305
Trypanosoma brucei	DNA polymerase kappa, putative	0.003	0.023	0.2898
Leishmania major	heat shock protein 83-1	0.0069	0.0771	0.9698
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0172	0.2199	1
Schistosoma mansoni	rotamase	0.0036	0.0305	0.0305
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.0014	0.0007	0.0015
Leishmania major	heat shock protein 83-1	0.0069	0.0771	0.9698
Plasmodium vivax	DNA topoisomerase II, putative	0.0014	0.0007	0.0089
Mycobacterium ulcerans	beta-lactamase	0.0043	0.0413	0.188
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0055	0.0576	1
Echinococcus multilocularis	dna polymerase kappa	0.0044	0.0419	0.0417
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0043	0.0413	0.1114
Brugia malayi	chromobox protein homolog 3	0.0047	0.0465	0.1019
Echinococcus multilocularis	caspase 3	0.0155	0.1959	0.1957
Trypanosoma brucei	heat shock protein, putative	0.0069	0.0771	0.9698
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0595	0.1263
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0054	0.011
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0353	0.4699	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.4699	1
Entamoeba histolytica	heat shock protein 90, putative	0.0069	0.0771	0.1637
Trypanosoma brucei	heat shock protein, putative	0.0069	0.0771	0.9698
Onchocerca volvulus		0.0043	0.0413	0.1241
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0057	0.0595	0.1263
Leishmania major	DNA polymerase kappa, putative	0.0044	0.0419	0.527
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0047	0.0465	0.1395
Leishmania major	DNA polymerase eta, putative	0.0071	0.0795	1
Echinococcus granulosus	caspase 3	0.0155	0.1959	0.1957
Plasmodium vivax	endoplasmin, putative	0.0069	0.0771	1
Trichomonas vaginalis	heat shock protein, putative	0.0055	0.0576	0.1221
Trichomonas vaginalis	receptor histidine kinase, putative	0.0014	0.0007	0.001
Leishmania major	heat shock protein 83-1	0.0069	0.0771	0.9698
Trypanosoma brucei	DNA polymerase IV, putative	0.0044	0.0419	0.527
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0057	0.0595	0.1263
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0016	0.0026	0.0024
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0274	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0261	0.0573
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0035	0.0293	0.3684
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0343	0.0343
Brugia malayi	beta-lactamase family protein	0.0043	0.0413	0.0907
Echinococcus multilocularis	heat shock protein 90	0.0069	0.0771	0.0769
Brugia malayi	Protein cec-1.	0.0014	0.0002	0.0005
Loa Loa (eye worm)	heat shock protein 90	0.0069	0.0771	0.1691
Schistosoma mansoni	eyes absent homolog	0.0094	0.1112	0.1112
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0044	0.0419	0.0888
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.4699	1
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0014	0.0007	0.0086
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0017	0.0045	0.0579
Trypanosoma brucei	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative	0.0014	0.0007	0.0086
Trichomonas vaginalis	endoplasmin, putative	0.0043	0.04	0.0847
Trypanosoma cruzi	heat shock protein 85, putative	0.0069	0.0771	0.9698
Treponema pallidum	fructose-bisphosphate aldolase	0.0353	0.4699	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.4699	1
Mycobacterium ulcerans	DNA polymerase IV	0.0044	0.0419	0.1906
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0299	0.3877
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0419	0.527
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0576	0.0574
Trichomonas vaginalis	DNA topoisomerase II, putative	0.0014	0.0007	0.001
Plasmodium falciparum	endoplasmin, putative	0.0043	0.04	0.5189
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.0028	0.0205	0.0203
Loa Loa (eye worm)	heat shock protein 75	0.0028	0.0205	0.0449
Schistosoma mansoni	microtubule-associated protein tau	0.0736	1	1
Echinococcus granulosus	chromobox protein 1	0.0084	0.0977	0.0975
Echinococcus granulosus	cpg binding protein	0.0032	0.026	0.0258
Toxoplasma gondii	heat shock protein 75, putative	0.0028	0.0205	0.2654
Plasmodium falciparum	chromodomain-helicase-DNA-binding protein 1 homolog, putative	0.0014	0.0002	0.0027
Schistosoma mansoni	heat shock protein	0.0069	0.0771	0.0771
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0413	0.0876
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0044	0.0419	0.527
Echinococcus granulosus	lamin	0.0029	0.021	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0795	0.1744
Trypanosoma cruzi	developmentally regulated phosphoprotein, putative	0.0014	0.0007	0.0086
Echinococcus multilocularis	cpg binding protein	0.0032	0.026	0.0258
Schistosoma mansoni	hypothetical protein	0.0029	0.0213	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0323	0.0709
Brugia malayi	jmjC domain containing protein	0.0115	0.1408	0.3089
Mycobacterium ulcerans	two component sensor histidine kinase TrcS	0.0014	0.0007	0.0031
Schistosoma mansoni	caspase-7 (C14 family)	0.0212	0.2743	0.2743
Brugia malayi	Hsp90 protein	0.0028	0.0205	0.0449
Onchocerca volvulus		0.0014	0.0002	0.000000055674
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0046	0.0452	0.0452
Schistosoma mansoni	DNA topoisomerase II	0.0014	0.0007	0.0007
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0059	0.0631	0.8182
Trypanosoma brucei	heat shock protein, putative	0.0069	0.0771	0.9698
Leishmania major	heat shock protein 83-1	0.0069	0.0771	0.9698
Toxoplasma gondii	heat shock protein 90, putative	0.0069	0.0771	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.003	0.023	0.2898
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0413	0.0876
Brugia malayi	beta-lactamase family protein	0.0043	0.0413	0.0907
Brugia malayi	PHD-finger family protein	0.0035	0.0299	0.0656
Echinococcus granulosus	PHD finger protein rhinoceros	0.0035	0.0299	0.0297
Echinococcus granulosus	intermediate filament protein	0.0029	0.021	0.0208
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0236	0.0234
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0413	0.52
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0007	0.0015
Leishmania major	hypothetical protein, conserved	0.0014	0.0007	0.0086
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0044	0.0419	0.0419
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0051	0.0514	0.1544
Entamoeba histolytica	DNA topoisomerase II, putative	0.0014	0.0007	0.001
Mycobacterium ulcerans	two component sensor histidine kinase SenX3	0.0014	0.0007	0.0031
Chlamydia trachomatis	DNA gyrase subunit B	0.0014	0.0007	0.5
Brugia malayi	M-phase phosphoprotein, mpp8	0.0014	0.0002	0.0005
Trichomonas vaginalis	sensory transduction histidine kinase bacterial, putative	0.0014	0.0007	0.001
Mycobacterium leprae	conserved hypothetical protein	0.0043	0.0413	0.1855
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0002	0.0005
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.002	0.0092	0.0092
Giardia lamblia	PHD finger protein 15	0.0035	0.0299	0.0636
Echinococcus granulosus	peregrin	0.0035	0.0299	0.0297
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0413	0.0907
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.3658	1
Plasmodium falciparum	heat shock protein 90	0.0069	0.0771	1
Echinococcus multilocularis	isocitrate dehydrogenase	0.0017	0.0045	0.0043
Schistosoma mansoni	DNA polymerase eta	0.0071	0.0795	0.0795
Echinococcus multilocularis	endoplasmin	0.0055	0.0576	0.0574
Echinococcus multilocularis	survival motor neuron protein 1	0.0252	0.3303	0.3301
Schistosoma mansoni	chromobox protein	0.0084	0.0977	0.0977
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0014	0.0002	0.0027
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0035	0.0299	0.0297
Trypanosoma brucei	unspecified product	0.003	0.023	0.2898
Toxoplasma gondii	ABC1 family protein	0.0043	0.0413	0.5362
Leishmania major	heat shock protein 83-1	0.0069	0.0771	0.9698
Leishmania major	heat shock protein 83-1	0.0069	0.0771	0.9698
Trichomonas vaginalis	rotamase, putative	0.0036	0.0305	0.0644
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0274	0.0579
Schistosoma mansoni	chromobox protein	0.0084	0.0977	0.0977
Toxoplasma gondii	Hsp90 domain-containing protein	0.0028	0.0205	0.2654
Plasmodium vivax	DNA gyrase subunit B, putative	0.0014	0.0007	0.0089
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0098	0.0205
Echinococcus multilocularis	caspase	0.0212	0.2743	0.2741
Plasmodium vivax	heat shock protein 90, putative	0.0028	0.0205	0.2654
Echinococcus granulosus	tumor protein p63	0.036	0.48	0.4799
Mycobacterium ulcerans	two component regulator - sensor kinase	0.0014	0.0007	0.0031
Echinococcus multilocularis	DNA topoisomerase 2 alpha	0.0014	0.0007	0.0005
Echinococcus multilocularis	dnaJ subfamily B	0.0436	0.585	0.585
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0419	0.527
Toxoplasma gondii	isocitrate dehydrogenase	0.0017	0.0045	0.0579
Trypanosoma brucei	metacaspase	0.0057	0.0595	0.7484
Trypanosoma brucei	heat shock protein, putative	0.0069	0.0771	0.9698
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0016	0.0026	0.0024
Trypanosoma brucei	heat shock protein 84, putative	0.0028	0.0205	0.2574
Echinococcus multilocularis	jumonji domain containing protein	0.0049	0.049	0.0488
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0595	0.1263
Schistosoma mansoni	cpg binding protein	0.0031	0.0235	0.0235
Echinococcus granulosus	heat shock protein 90	0.0055	0.0576	0.0574
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0014	0.0007	0.0089
Echinococcus granulosus	expressed protein	0.0036	0.0305	0.0303
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0044	0.0419	0.1129
Trypanosoma brucei	metacaspase MCA2	0.0057	0.0595	0.7484
Mycobacterium ulcerans	putative regultory protein	0.0014	0.0007	0.0031
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0098	0.0205
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0014	0.0007	0.0014
Trypanosoma brucei	developmentally regulated phosphoprotein	0.0014	0.0007	0.0086
Brugia malayi	Pre-SET motif family protein	0.0223	0.2893	0.6346
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0419	0.527
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0261	0.339
Trichomonas vaginalis	chromobox protein, putative	0.0084	0.0977	0.2075
Plasmodium falciparum	DNA gyrase subunit B	0.0014	0.0007	0.0089
Echinococcus multilocularis	musashi	0.0029	0.021	0.0208
Trypanosoma cruzi	metacaspase, putative	0.0057	0.0595	0.7484
Chlamydia trachomatis	DNA gyrase subunit B	0.0014	0.0007	0.5
Brugia malayi	hypothetical protein	0.0252	0.3303	0.7244
Schistosoma mansoni	heat shock protein	0.0069	0.0771	0.0771
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0413	0.0907
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.0413	0.188
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0004	0.0008
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0014	0.0004	0.0001
Echinococcus granulosus	jumonji domain containing protein	0.0049	0.049	0.0488
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0002	0.0005
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.4699	1
Leishmania major	heat shock protein 83-1	0.0069	0.0771	0.9698
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0413	0.0907
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0057	0.0595	0.1263
Trypanosoma brucei	heat shock protein, putative	0.0069	0.0771	0.9698
Brugia malayi	mucosa associated lymphoid tissue lymphoma translocation protein 1	0.0057	0.0595	0.1305
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0413	0.0411
Leishmania major	heat shock protein 83-1	0.0069	0.0771	0.9698
Brugia malayi	hypothetical protein	0.0038	0.0343	0.0751
Leishmania major	mitochondrial DNA topoisomerase II	0.0014	0.0007	0.0086
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0044	0.0419	0.0417
Brugia malayi	jmjC domain containing protein	0.0044	0.0426	0.0934
Mycobacterium tuberculosis	Probable lipase LipE	0.0043	0.0413	0.1114
Trypanosoma cruzi	heat shock protein 90, putative	0.0055	0.0576	0.724
Echinococcus granulosus	endoplasmin	0.0055	0.0576	0.0574
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0014	0.0007	0.0005
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0057	0.0595	0.1263
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0021	0.0098	0.0205
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0576	0.0574
Schistosoma mansoni	subfamily C14A unassigned peptidase (C14 family)	0.0057	0.0595	0.0595
Entamoeba histolytica	heat shock protein 90, putative	0.0069	0.0771	0.1637
Onchocerca volvulus		0.0043	0.0413	0.1241
Leishmania major	heat shock protein 83-1	0.0069	0.0771	0.9698
Trypanosoma brucei	DNA polymerase IV, putative	0.0044	0.0419	0.527
Plasmodium vivax	SET domain protein, putative	0.0032	0.0261	0.339
Treponema pallidum	heat shock protein 90	0.0055	0.0576	0.1212
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0343	0.0341
Leishmania major	heat shock protein 83-1	0.0069	0.0771	0.9698
Echinococcus granulosus	heat shock protein	0.0069	0.0771	0.0769
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0115	0.1408	0.1406
Toxoplasma gondii	heat shock protein HSP90	0.0069	0.0771	1
Trichomonas vaginalis	set domain proteins, putative	0.0253	0.3318	0.706
Mycobacterium tuberculosis	Probable esterase LipL	0.0043	0.0413	0.1114
Plasmodium vivax	heat shock protein 86, putative	0.0069	0.0771	1
Trypanosoma cruzi	heat shock protein 85, putative	0.0069	0.0771	0.9698
Toxoplasma gondii	peptidylprolyl isomerase	0.0035	0.0293	0.3799
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.4699	1
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0035	0.0293	0.3684
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0413	0.1114
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0002	0.0005
Trypanosoma brucei	unspecified product	0.003	0.023	0.2898
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0057	0.0595	0.1263
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0007	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0202	0.0444
Schistosoma mansoni	cpg binding protein	0.0032	0.026	0.026
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0002	0.0005
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0041	0.0376	0.4877
Trypanosoma cruzi	metacaspase, putative	0.0057	0.0595	0.7484
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0595	0.1305
Echinococcus multilocularis	chromobox protein 1	0.0084	0.0977	0.0975
Brugia malayi	ImpB/MucB/SamB family protein	0.0071	0.0795	0.1744
Mycobacterium ulcerans	two component sensor histidine kinase PrrB	0.0014	0.0007	0.0031
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0017	0.0045	0.0043
Trichomonas vaginalis	conserved hypothetical protein	0.0057	0.0595	0.1263
Loa Loa (eye worm)	helicase	0.0014	0.0002	0.0005
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0353	0.4699	1
Trypanosoma brucei	metacaspase 5, putative	0.0057	0.0595	0.7484
Plasmodium vivax	hypothetical protein, conserved	0.0014	0.0007	0.0089
Trypanosoma brucei	DNA topoisomerase ii	0.0014	0.0007	0.0086
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0014	0.0007	0.0086
Brugia malayi	Associated with TFs and helicases family protein	0.0014	0.0002	0.0005
Trichomonas vaginalis	mismatch repair protein Mlh1C (mutL homolog)	0.0014	0.0007	0.001
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0419	0.527
Echinococcus granulosus	heat shock protein 90	0.0069	0.0771	0.0769
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0021	0.0098	0.0205
Schistosoma mansoni	hypothetical protein	0.0436	0.585	0.585
Toxoplasma gondii	isocitrate dehydrogenase	0.0017	0.0045	0.0579
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0261	0.0259
Mycobacterium ulcerans	DNA polymerase IV	0.0044	0.0419	0.1906
Onchocerca volvulus		0.0029	0.021	0.0626

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.7079 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	= 2.5119 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	3.6964 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 7.0795 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Giardia lamblia growth inhibition. (Class of assay: confirmatory) [Related pubchem assays: 2451, 2472, 2464 ]	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	= 15.8489 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ]	ChEMBL.	No reference
Potency (functional)	17.7828 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (binding)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)]	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1546275

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1414092