Detailed information for compound 1419569

Basic information

Technical information
  • TDR Targets ID: 1419569
  • Name: dimethyl 5-amino-3-[[5-(4-bromophenyl)-4-prop -2-enyl-1,2,4-triazol-3-yl]sulfanylmethyl]thi ophene-2,4-dicarboxylate
  • MW: 523.423 | Formula: C20H19BrN4O4S2
  • H donors: 1 H acceptors: 4 LogP: 4.79 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: C=CCn1c(SCc2c(sc(c2C(=O)OC)N)C(=O)OC)nnc1c1ccc(cc1)Br
  • InChi: 1S/C20H19BrN4O4S2/c1-4-9-25-17(11-5-7-12(21)8-6-11)23-24-20(25)30-10-13-14(18(26)28-2)16(22)31-15(13)19(27)29-3/h4-8H,1,9-10,22H2,2-3H3
  • InChiKey: SVQOGGRRFIZAGR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • dimethyl 3-[[4-allyl-5-(4-bromophenyl)-1,2,4-triazol-3-yl]sulfanylmethyl]-5-amino-thiophene-2,4-dicarboxylate
  • 3-[[[4-allyl-5-(4-bromophenyl)-1,2,4-triazol-3-yl]thio]methyl]-5-aminothiophene-2,4-dicarboxylic acid dimethyl ester
  • 3-[[[4-allyl-5-(4-bromophenyl)-1,2,4-triazol-3-yl]thio]methyl]-5-amino-thiophene-2,4-dicarboxylic acid dimethyl ester
  • ZINC03393542
  • T5290451
  • MLS000567806
  • SMR000154264

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans second version of adenosylmethionine-8-amino-7-oxononanoate aminotransferase Get druggable targets OG5_128068 All targets in OG5_128068
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans adenosylmethionine-8-amino-7-oxononanoate aminotransferase similar to that found in bacteria Get druggable targets OG5_128068 All targets in OG5_128068
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans adenosylmethionine-8-amino-7-oxononanoate aminotransferase similar to that found in bacteria Get druggable targets OG5_128068 All targets in OG5_128068
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA Get druggable targets OG5_128068 All targets in OG5_128068
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_128068 All targets in OG5_128068
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Probable aminotransferase Get druggable targets OG5_128068 All targets in OG5_128068
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA Get druggable targets OG5_128068 All targets in OG5_128068
Candida albicans second version of adenosylmethionine-8-amino-7-oxononanoate aminotransferase Get druggable targets OG5_128068 All targets in OG5_128068
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase Get druggable targets OG5_128068 All targets in OG5_128068
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis acetylornithine aminotransferase, putative Get druggable targets OG5_128068 All targets in OG5_128068
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 437 aa 397 aa 28.5 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1462 0.1717
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0929 1
Plasmodium vivax ornithine aminotransferase, putative 0.0026 0.0458 0.2207
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1462 0.1717
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0232 0.1138
Loa Loa (eye worm) beta-lactamase 0.0035 0.0693 0.0898
Mycobacterium ulcerans hypothetical protein 0.0184 0.4463 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0232 0.0495
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0929 0.4871
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.081 0.1785
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1462 0.1717
Loa Loa (eye worm) hypothetical protein 0.0232 0.5695 0.7536
Schistosoma mansoni cpg binding protein 0.0028 0.0511 0.0496
Brugia malayi hypothetical protein 0.0035 0.0692 0.0901
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0693 0.1226
Plasmodium vivax histone acetyltransferase GCN5, putative 0.009 0.2075 1
Schistosoma mansoni hypothetical protein 0.0041 0.0841 0.0826
Loa Loa (eye worm) hypothetical protein 0.0012 0.0087 0.0095
Mycobacterium tuberculosis Conserved protein 0.0035 0.0693 0.1226
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.002 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0232 0.0495
Mycobacterium ulcerans acetylornithine aminotransferase 0.0026 0.0458 0.0994
Schistosoma mansoni cpg binding protein 0.003 0.0552 0.0537
Echinococcus granulosus cathepsin l1 0.0017 0.0232 0.0216
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0232 0.0216
Echinococcus granulosus histone acetyltransferase KAT2B 0.009 0.2075 0.2063
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1375 0.1361
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0693 0.0678
Loa Loa (eye worm) hypothetical protein 0.0035 0.0693 0.0898
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0232 0.0495
Mycobacterium ulcerans beta-lactamase 0.0035 0.0693 0.1522
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0009 0.0025 0.0009
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0232 0.0216
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0232 0.0495
Entamoeba histolytica hypothetical protein 0.0035 0.0692 0.3603
Brugia malayi beta-lactamase family protein 0.0035 0.0693 0.0901
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0026 0.0458 0.0801
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0692 0.0677
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.1007 0.1175
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.1294 0.5762
Loa Loa (eye worm) fibroinase 0.0017 0.0232 0.0287
Loa Loa (eye worm) ctsf protein 0.0017 0.0232 0.0287
Entamoeba histolytica cysteine protease, putative 0.0017 0.0232 0.1138
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0693 0.0801
Onchocerca volvulus 0.0035 0.0693 0.6649
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0232 0.0287
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0232 0.0495
Onchocerca volvulus 0.0017 0.0232 0.159
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.1462 0.1717
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0693 0.0801
Echinococcus multilocularis cpg binding protein 0.003 0.0552 0.0537
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.1105 0.1292
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0026 0.0458 0.0994
Loa Loa (eye worm) inositol-1 0.0045 0.0929 0.1211
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0693 0.153
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1314 0.13
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0016 0.0000011448
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.3292 0.3281
Loa Loa (eye worm) hypothetical protein 0.0017 0.0232 0.0287
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1462 0.1717
Echinococcus granulosus GPCR family 2 0.0019 0.0279 0.0263
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0232 0.0216
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0232 0.0495
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.081 0.1438
Plasmodium falciparum histone acetyltransferase GCN5 0.0082 0.1885 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1462 0.1717
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0232 0.0495
Echinococcus multilocularis zinc finger protein 0.0009 0.0025 0.0009
Echinococcus multilocularis tar DNA binding protein 0.0062 0.1375 0.1361
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.009 0.2075 1
Onchocerca volvulus 0.0017 0.0232 0.159
Echinococcus granulosus Aminotransferase class III 0.0026 0.0458 0.0443
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0009 0.0025 0.0009
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.3292 0.3281
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0232 0.0216
Brugia malayi Cathepsin L-like precursor 0.0017 0.0232 0.029
Brugia malayi hypothetical protein 0.0232 0.5695 0.7537
Brugia malayi cathepsin L-like precursor 0.0012 0.0087 0.0098
Loa Loa (eye worm) hypothetical protein 0.006 0.1325 0.1737
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0232 0.1138
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0026 0.0458 0.0443
Schistosoma mansoni hypothetical protein 0.0035 0.0692 0.0677
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0841 0.1098
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.1294 0.128
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0058 0.1273 0.1491
Mycobacterium ulcerans lipase LipD 0.0035 0.0693 0.1522
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1294 0.2874
Echinococcus granulosus zinc finger protein 0.0009 0.0025 0.0009
Loa Loa (eye worm) TAR-binding protein 0.0062 0.1375 0.1803
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0279 0.0263
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.3292 0.3281
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.009 0.2075 0.4636
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0693 0.1226
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0693 0.1226
Onchocerca volvulus 0.0028 0.0511 0.4652
Trichomonas vaginalis esterase, putative 0.0035 0.0693 0.153
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0693 0.0678
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0232 0.0495
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0048 0.1007 0.1175
Brugia malayi beta-lactamase family protein 0.0035 0.0693 0.0901
Entamoeba histolytica hypothetical protein 0.0035 0.0692 0.3603
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1375 0.1361
Echinococcus multilocularis GPCR, family 2 0.0019 0.0279 0.0263
Schistosoma mansoni hypothetical protein 0.034 0.8453 0.8451
Brugia malayi Cathepsin L-like precursor 0.0017 0.0232 0.029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.002 0.0018
Schistosoma mansoni hypothetical protein 0.0047 0.0998 0.0983
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0279 0.0263
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.1462 0.1717
Entamoeba histolytica hypothetical protein 0.0035 0.0692 0.3603
Echinococcus granulosus geminin 0.034 0.8453 0.8451
Onchocerca volvulus 0.0035 0.0693 0.6649
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.002 0.0004
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.1007 0.1175
Trichomonas vaginalis bromodomain-containing protein, putative 0.009 0.2075 0.4636
Echinococcus multilocularis cysteine protease 0.0017 0.0232 0.0216
Plasmodium vivax vivapain-2 0.0017 0.0232 0.1118
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.3292 0.4347
Onchocerca volvulus 0.0017 0.0232 0.159
Brugia malayi Cathepsin L-like precursor 0.0012 0.0087 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0232 0.0495
Mycobacterium tuberculosis Conserved protein 0.0035 0.0693 0.1226
Toxoplasma gondii ABC1 family protein 0.0035 0.0693 0.2498
Echinococcus granulosus ornithine aminotransferase 0.0026 0.0458 0.0443
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0693 0.0678
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0026 0.0458 0.0801
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0693 0.1522
Schistosoma mansoni inositol monophosphatase 0.0045 0.0929 0.0914
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0232 0.0495
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0232 0.0495
Brugia malayi acetyltransferase, GNAT family protein 0.0305 0.7551 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0929 0.1082
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0693 0.153
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0087 0.0072
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0929 0.3778
Onchocerca volvulus 0.0035 0.0693 0.6649
Entamoeba histolytica hypothetical protein 0.0035 0.0692 0.3603
Mycobacterium ulcerans L-lysine aminotransferase 0.0026 0.0458 0.0994
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0693 0.1226
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0232 0.0216
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0232 0.0495
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0232 0.159
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0087 0.0098
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1375 0.1361
Loa Loa (eye worm) hypothetical protein 0.0012 0.0087 0.0095
Echinococcus multilocularis dnaJ subfamily B 0.0401 1 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.1342 0.6021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0232 0.0495
Loa Loa (eye worm) cysteine protease 0.0017 0.0232 0.0287
Mycobacterium ulcerans hypothetical protein 0.0035 0.0693 0.1522
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.3292 0.435
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0232 0.029
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0026 0.0458 0.1225
Giardia lamblia Histone acetyltransferase GCN5 0.0082 0.1885 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0232 0.0495
Loa Loa (eye worm) hypothetical protein 0.0009 0.0025 0.0012
Toxoplasma gondii hypothetical protein 0.0055 0.1186 0.5174
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0693 0.153
Echinococcus multilocularis cysteine protease 0.0017 0.0232 0.0216
Brugia malayi TAR-binding protein 0.0062 0.1375 0.1806
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0232 0.1138
Brugia malayi Cathepsin L-like precursor 0.0017 0.0232 0.029
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0692 0.0677
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0279 0.0349
Brugia malayi Bromodomain containing protein 0.0009 0.0025 0.0016
Schistosoma mansoni hypothetical protein 0.0019 0.0279 0.0263
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1462 0.1717
Mycobacterium leprae Probable lipase LipE 0.0035 0.0693 0.1522
Schistosoma mansoni cpg binding protein 0.003 0.0552 0.0537
Leishmania major cathepsin L-like protease 0.0066 0.1462 0.1502
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0693 0.1226
Loa Loa (eye worm) hypothetical protein 0.0035 0.0693 0.0898
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0279 0.0263
Trichomonas vaginalis ferritin, putative 0.0009 0.0016 0.0009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.3292 0.3281
Loa Loa (eye worm) hypothetical protein 0.0019 0.0279 0.0349
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0279 0.0352
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0232 0.0253
Brugia malayi PHD-finger family protein 0.0009 0.0025 0.0016
Echinococcus multilocularis ornithine aminotransferase 0.0026 0.0458 0.0443
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0232 0.0495
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.1318 0.1545
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0184 0.4463 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0232 0.0495
Mycobacterium tuberculosis Probable aminotransferase 0.0184 0.4463 0.8059
Brugia malayi beta-lactamase 0.0035 0.0693 0.0901
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0929 0.206
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.3292 0.3281
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1462 0.1717
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0929 0.1082
Brugia malayi Inositol-1 0.0045 0.0929 0.1214
Schistosoma mansoni zinc finger protein 0.0009 0.0025 0.0009
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0232 0.159
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0026 0.0458 0.0994
Echinococcus multilocularis geminin 0.034 0.8453 0.8451
Leishmania major cathepsin L-like protease 0.0066 0.1462 0.1502
Echinococcus granulosus histone acetyltransferase KAT2B 0.0296 0.7334 0.7329
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0693 0.0801
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1294 0.2874
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0232 0.0495
Loa Loa (eye worm) RNA binding protein 0.0062 0.1375 0.1803
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0339 0.8422 1
Onchocerca volvulus 0.0017 0.0232 0.159
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0305 0.7551 0.7547
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0929 0.0914
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0026 0.0458 0.0994
Echinococcus multilocularis ornithine aminotransferase 0.0026 0.0458 0.0443
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0693 0.0901
Mycobacterium tuberculosis Conserved protein 0.0035 0.0693 0.1226
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0998 0.1306
Onchocerca volvulus 0.0017 0.0232 0.159
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0693 0.1522
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0929 0.0914
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0929 0.085
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.1294 0.2316
Schistosoma mansoni inositol monophosphatase 0.0045 0.0929 0.0914
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0279 0.0263
Echinococcus granulosus cathepsin L 0.0009 0.002 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0087 0.017
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.1294 0.128
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0232 0.0287
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0693 0.0678
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0026 0.0458 0.0994
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0026 0.0458 0.0994
Loa Loa (eye worm) hypothetical protein 0.0009 0.0025 0.0012
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0693 0.1522
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0232 0.159
Loa Loa (eye worm) hypothetical protein 0.0035 0.0693 0.0898
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0232 0.0216
Brugia malayi Cathepsin L-like precursor 0.0012 0.0087 0.0098
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.5695 0.5688
Echinococcus multilocularis cathepsin L 0.0009 0.002 0.0004
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0026 0.0458 0.4843
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1462 0.1717
Onchocerca volvulus 0.0047 0.0998 1
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0026 0.0458 0.0801
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.5695 0.5688
Plasmodium falciparum ornithine aminotransferase 0.0026 0.0458 0.2349
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0232 0.0495
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0232 0.0495
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0161 0.3877 0.4591
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0232 0.0495
Treponema pallidum bacterioferrin (TpF1) 0.0009 0.0016 0.5
Brugia malayi RNA binding protein 0.0062 0.1375 0.1806
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1294 0.2874
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0184 0.4463 1
Schistosoma mansoni bromodomain containing protein 0.0009 0.0025 0.0009
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.1294 0.1297
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1325 0.1737
Schistosoma mansoni hypothetical protein 0.0401 1 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1375 0.1361
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.1375 0.1803
Brugia malayi Cathepsin L-like precursor 0.0017 0.0232 0.029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0087 0.017
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0693 0.3337
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0693 0.153
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0232 0.0495
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0929 0.206
Loa Loa (eye worm) hypothetical protein 0.0041 0.0841 0.1095
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.002 0.0009
Loa Loa (eye worm) acetyltransferase 0.0305 0.7551 1
Echinococcus granulosus cpg binding protein 0.003 0.0552 0.0537
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0929 0.2052
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.1294 0.128
Brugia malayi Cathepsin L-like precursor 0.0017 0.0232 0.029
Loa Loa (eye worm) hypothetical protein 0.0035 0.0693 0.0898
Schistosoma mansoni survival motor neuron protein 0.0047 0.0998 0.0983
Leishmania major cathepsin L-like protease 0.0066 0.1462 0.1502
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0339 0.8422 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0232 0.0216
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.002 0.0009
Leishmania major hypothetical protein, conserved 0.0035 0.0693 0.0562
Echinococcus granulosus cathepsin l1 0.0012 0.0087 0.0072
Echinococcus granulosus cysteine protease 0.0009 0.002 0.0004
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0232 0.0216
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.002 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0232 0.0495
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.002 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.3292 0.3281
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0026 0.0458 0.0994
Onchocerca volvulus 0.0017 0.0232 0.159
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0232 0.0495
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0026 0.0458 0.0801
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0693 0.153
Echinococcus granulosus cathepsin L cysteine protease 0.0009 0.002 0.0004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.3292 0.3281
Schistosoma mansoni hypothetical protein 0.034 0.8453 0.8451
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1325 0.1741
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0693 0.1226
Schistosoma mansoni hypothetical protein 0.0019 0.0279 0.0263
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0184 0.4463 1
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.1375 0.1806
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0305 0.7551 0.7547
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0161 0.3877 0.4451
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1462 0.1717
Loa Loa (eye worm) hypothetical protein 0.0012 0.0087 0.0095
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.1462 0.1717
Plasmodium vivax vivapain-3 0.0009 0.002 0.0096
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1462 0.1717
Schistosoma mansoni bromodomain containing protein 0.0009 0.0025 0.0009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0232 0.0495
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1375 0.1361
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0279 0.0352
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0693 0.1226
Loa Loa (eye worm) hypothetical protein 0.0035 0.0693 0.0898
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0232 0.0495
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0184 0.4463 0.8059
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.1294 0.128
Leishmania major mitochondrial DNA polymerase beta 0.0339 0.8422 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0179 0.4339 0.7834
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0087 0.0362
Schistosoma mansoni hypothetical protein 0.0019 0.0279 0.0263
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.5534 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0692 0.0677
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0048 0.1007 0.1175
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0026 0.0458 0.5
Echinococcus granulosus tar DNA binding protein 0.0062 0.1375 0.1361
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0026 0.0458 0.0994
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.1462 0.1717
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0929 0.1082
Loa Loa (eye worm) hypothetical protein 0.0035 0.0693 0.0898
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0026 0.0458 0.059
Plasmodium vivax unspecified product 0.0009 0.002 0.0096
Entamoeba histolytica acetyltransferase, GNAT family 0.0082 0.1885 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.1462 0.1717
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0339 0.8422 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0511 0.066
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0693 0.0898
Echinococcus multilocularis Aminotransferase class III 0.0026 0.0458 0.0443
Schistosoma mansoni hypothetical protein 0.0019 0.0279 0.0263
Brugia malayi Cathepsin L-like precursor 0.0017 0.0232 0.029
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0232 0.1138
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0511 0.0657
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0161 0.3877 0.4591
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.009 0.2075 1
Onchocerca volvulus 0.0017 0.0232 0.159
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1325 0.1741
Mycobacterium ulcerans hypothetical protein 0.0179 0.4339 0.9721
Plasmodium vivax vivapain-2 0.0017 0.0232 0.1118
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0232 0.1138
Plasmodium vivax vivapain-1 0.0009 0.002 0.0096
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0929 0.206
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0016 0.0000011448

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) 0.233 uM PubChem BioAssay. Mycobacterium tuberculosis BioA enzyme inhibitor Measured in Biochemical System Using Plate Reader - 2163-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.7783 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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