Detailed information for compound 1423540

Basic information

Technical information
  • TDR Targets ID: 1423540
  • Name: NSC-121865
  • MW: 412.479 | Formula: C23H28N2O5
  • H donors: 2 H acceptors: 2 LogP: -0.88 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2c(cc1OC)N[C@H]1[C@@]32CCN2[C@H]3C[C@@H]3[C@H]1[C@H](OCC=C3C2)CC(=O)O
  • InChi: 1S/C23H28N2O5/c1-28-16-8-14-15(9-17(16)29-2)24-22-21-13-7-19-23(14,22)4-5-25(19)11-12(13)3-6-30-18(21)10-20(26)27/h3,8-9,13,18-19,21-22,24H,4-7,10-11H2,1-2H3,(H,26,27)/t13-,18+,19-,21-,22+,23+/m0/s1
  • InChiKey: RJTMEFDVTNQHTN-CPHLOYQUSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • NCGC00014245

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Bacillus anthracis Anthrax lethal factor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Alhambra homolog 0.0028 0.0014 0.0009
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0076 0.01 0.0719
Schistosoma mansoni retinoic acid receptor RXR 0.013 0.0195 0.0199
Echinococcus multilocularis lamin 0.0142 0.0218 0.0223
Brugia malayi intermediate filament protein 0.0142 0.0218 0.0295
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0462
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0094 0.0132 0.0128
Echinococcus granulosus muscleblind protein 0.0167 0.0263 0.027
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0218 0.0354 0.0482
Toxoplasma gondii ABC1 family protein 0.0035 0.0026 0.0062
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0026 0.0458
Leishmania major telomerase reverse transcriptase, putative 0.1527 0.2704 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0033
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0027 0.2107
Echinococcus granulosus survival motor neuron protein 1 0.0246 0.0404 0.0418
Onchocerca volvulus 0.0057 0.0066 0.0061
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0095 1
Brugia malayi MH2 domain containing protein 0.0761 0.1328 0.1825
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0011 0.0058
Trypanosoma cruzi target of rapamycin kinase 3 0.004 0.0034 0.0031
Echinococcus multilocularis muscleblind protein 0.0167 0.0263 0.027
Brugia malayi photoreceptor-specific nuclear receptor 0.013 0.0195 0.0263
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0033
Loa Loa (eye worm) hypothetical protein 0.013 0.0195 0.1442
Echinococcus multilocularis chromobox protein 1 0.0157 0.0244 0.025
Mycobacterium tuberculosis Conserved protein 0.0035 0.0026 0.046
Toxoplasma gondii target of rapamycin (TOR), putative 0.0037 0.0029 0.0076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.013 0.0195 0.1442
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0011 0.006
Echinococcus multilocularis nuclear receptor nhr 48 0.0057 0.0066 0.0064
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0069 0.0086 0.0085
Loa Loa (eye worm) hypothetical protein 0.0159 0.0249 0.1844
Brugia malayi Nuclear hormone receptor-like 1 0.0072 0.0093 0.0121
Brugia malayi MH2 domain containing protein 0.0052 0.0056 0.0071
Echinococcus multilocularis musashi 0.0142 0.0218 0.0223
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0095 1
Echinococcus granulosus lamin 0.0142 0.0218 0.0223
Plasmodium falciparum telomerase reverse transcriptase 0.1527 0.2704 1
Onchocerca volvulus 0.0026 0.0009 0.0004
Schistosoma mansoni hypothetical protein 0.0218 0.0354 0.0365
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0023 0.0378
Schistosoma mansoni thyroid hormone receptor 0.013 0.0195 0.0199
Loa Loa (eye worm) hypothetical protein 0.0035 0.0026 0.016
Brugia malayi beta-lactamase 0.0035 0.0026 0.0029
Loa Loa (eye worm) Smad1 0.0052 0.0056 0.0389
Echinococcus granulosus thyroid hormone receptor alpha 0.0202 0.0325 0.0335
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0095 1
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.0215 0.029
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.005 0.0052 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-25 0.013 0.0195 0.0263
Schistosoma mansoni hypothetical protein 0.0026 0.0009 0.0005
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0024 0.0005 0.0019
Schistosoma mansoni lamin 0.0142 0.0218 0.0223
Echinococcus multilocularis chromobox protein 1 0.0157 0.0244 0.025
Loa Loa (eye worm) transcription factor SMAD2 0.0761 0.1328 1
Brugia malayi cytoplasmic intermediate filament protein 0.0076 0.01 0.0131
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0072 0.0093 0.0092
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0026 0.0022
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0129 0.3262
Loa Loa (eye worm) hypothetical protein 0.013 0.0195 0.1442
Schistosoma mansoni zinc finger protein 0.0057 0.0066 0.0064
Giardia lamblia Telomerase catalytic subunit 0.1527 0.2704 1
Echinococcus multilocularis Chromo domain 0.0026 0.0009 0.0005
Schistosoma mansoni hypothetical protein 0.0028 0.0014 0.001
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0009 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0034 0.0681
Loa Loa (eye worm) hypothetical protein 0.0066 0.0082 0.0582
Echinococcus multilocularis muscleblind protein 1 0.0167 0.0263 0.027
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0462
Schistosoma mansoni nuclear receptor nhr-48 0.0057 0.0066 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.013 0.0195 0.1442
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.0215 0.022
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0009 0.0007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0128 0.0129
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0026 0.0009 0.0005
Loa Loa (eye worm) hypothetical protein 0.0167 0.0263 0.1952
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.013 0.0195 0.0199
Onchocerca volvulus Cell death protein 3 homolog 0.006 0.0071 0.0067
Schistosoma mansoni hypothetical protein 0.0471 0.0808 0.084
Brugia malayi Protein cec-1. 0.0026 0.0009 0.0006
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0072 0.0093 0.0665
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0011 0.006
Giardia lamblia Kinase, PLK 0.0092 0.0129 0.0428
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0026 0.0009 0.0005
Brugia malayi nuclear receptor NHR-67 0.0057 0.0066 0.0084
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.0129 0.0443
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0027 0.0502
Echinococcus multilocularis ecdysone induced protein 78C 0.013 0.0195 0.0199
Schistosoma mansoni hypothetical protein 0.0218 0.0354 0.0365
Brugia malayi hypothetical protein 0.0159 0.0249 0.0337
Echinococcus multilocularis peregrin 0.0032 0.002 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0011 0.0058
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0218 0.0354 0.0365
Echinococcus multilocularis smad 0.0052 0.0056 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0016 0.0186
Trichomonas vaginalis chromobox protein, putative 0.0094 0.0132 0.3364
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.005 0.0052 0.3613
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0024 0.0021
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.0129 1
Echinococcus granulosus lamin dm0 0.0142 0.0218 0.0223
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.0364 1
Schistosoma mansoni chromobox protein 0.0026 0.0009 0.0005
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0218 0.0354 0.0365
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0095 0.0094
Brugia malayi Nuclear hormone receptor E75 0.0057 0.0066 0.0084
Schistosoma mansoni chromobox protein 0.0157 0.0244 0.025
Mycobacterium leprae Probable lipase LipE 0.0035 0.0026 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.013 0.0195 0.0199
Brugia malayi hypothetical protein 0.0057 0.0066 0.0084
Schistosoma mansoni kinase 0.0047 0.0047 0.0045
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0095 0.0094
Onchocerca volvulus 0.005 0.0053 0.0048
Loa Loa (eye worm) hypothetical protein 0.0066 0.0082 0.0582
Loa Loa (eye worm) hypothetical protein 0.014 0.0214 0.158
Brugia malayi Nuclear hormone receptor-like 1 0.0072 0.0093 0.0121
Echinococcus granulosus chromobox protein 1 0.0157 0.0244 0.025
Loa Loa (eye worm) helicase 0.0026 0.0009 0.0033
Echinococcus granulosus apoptotic protease activating factor 1 0.006 0.0071 0.007
Brugia malayi jmjC domain containing protein 0.0034 0.0024 0.0027
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0129 0.0384
Brugia malayi ecdysteroid receptor 0.0284 0.0473 0.0646
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0057 0.0066 0.0064
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0088 0.012 0.0116
Schistosoma mansoni nuclear receptor 0.0057 0.0066 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0029 0.0556
Brugia malayi Intermediate filament tail domain containing protein 0.0142 0.0218 0.0295
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0026 0.1916
Brugia malayi Pre-SET motif family protein 0.0202 0.0326 0.0443
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0033
Echinococcus multilocularis chromobox protein 2 0.0026 0.0009 0.0005
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.013 0.0195 0.0199
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0128 0.0129
Mycobacterium tuberculosis Conserved protein 0.0035 0.0026 0.046
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0021 0.6854
Brugia malayi nuclear hormone receptor family member nhr-6 0.0057 0.0066 0.0084
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0015 0.0011
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0031 0.1832
Loa Loa (eye worm) hypothetical protein 0.013 0.0195 0.1442
Brugia malayi nuclear receptor NHR-88 0.013 0.0195 0.0263
Brugia malayi Nuclear hormone receptor family member nhr-41 0.013 0.0195 0.0263
Brugia malayi conserved hypotetical protein 0.0057 0.0066 0.0084
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0026 0.046
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0026 0.0458
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0014 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0029 0.0556
Echinococcus granulosus intermediate filament protein 0.0142 0.0218 0.0223
Trichomonas vaginalis chromobox protein, putative 0.0157 0.0244 0.6402
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0021 0.0315
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.0129 0.0938
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0026 0.0009 0.0005
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0027 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.012 0.3038
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0142 0.0218 0.1615
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0031 0.0081
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.013 0.0195 0.0199
Loa Loa (eye worm) hypothetical protein 0.013 0.0195 0.1442
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0052 0.1179
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0057 0.0066 0.0084
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0026 0.046
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0045 0.0982
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0027 0.0024
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0057 0.0066 0.0064
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0027 0.0067
Schistosoma mansoni hypothetical protein 0.0218 0.0354 0.0365
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0027 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0034 0.0681
Schistosoma mansoni hypothetical protein 0.0355 0.06 0.0622
Echinococcus granulosus chromobox protein 1 0.0157 0.0244 0.025
Brugia malayi Nuclear hormone receptor family member nhr-40 0.013 0.0195 0.0263
Echinococcus multilocularis tumor protein p63 0.1104 0.1945 0.2027
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.005 0.0052 0.005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0128 0.0129
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0026 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0015 0.0011
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0026 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0029 0.0556
Brugia malayi CHD4 protein 0.0026 0.0009 0.0006
Loa Loa (eye worm) hypothetical protein 0.0029 0.0015 0.0079
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0129 0.3262
Loa Loa (eye worm) hypothetical protein 0.013 0.0195 0.1442
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0057 0.0066 0.0061
Loa Loa (eye worm) hypothetical protein 0.0028 0.0014 0.0069
Loa Loa (eye worm) CHromoDomain protein family member 0.0026 0.0009 0.0033
Trypanosoma brucei polo-like protein kinase 0.0092 0.0129 0.0476
Loa Loa (eye worm) nuclear hormone receptor 0.0057 0.0066 0.0462
Echinococcus granulosus peregrin 0.0032 0.002 0.0016
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0128 0.0129
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0057 0.0066 0.0064
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0009 0.0042
Brugia malayi MH1 domain containing protein 0.0052 0.0056 0.0071
Loa Loa (eye worm) hypothetical protein 0.013 0.0195 0.1442
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0218 0.0354 0.0365
Brugia malayi beta-lactamase family protein 0.0035 0.0026 0.0029
Loa Loa (eye worm) heterochromatin protein 1 0.0157 0.0244 0.1809
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0026 0.046
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.0129 0.0124
Schistosoma mansoni nuclear receptor 0.0057 0.0066 0.0064
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0033 0.003
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.013 0.0195 0.0199
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0208 0.0212
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0027 0.0024
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0037
Echinococcus granulosus smad 0.0052 0.0056 0.0054
Brugia malayi Telomerase reverse transcriptase 0.4065 0.7258 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.005 0.0343
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0031 0.0064
Onchocerca volvulus 0.006 0.0071 0.0067
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0033
Onchocerca volvulus 0.0026 0.0009 0.0005
Schistosoma mansoni smad1 5 8 and 0.0052 0.0056 0.0054
Loa Loa (eye worm) hypothetical protein 0.0035 0.0026 0.016
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0027 0.0502
Schistosoma mansoni nuclear hormone receptor 0.0057 0.0066 0.0064
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.0326 0.2428
Onchocerca volvulus Bile acid receptor homolog 0.0284 0.0473 0.0469
Brugia malayi Heterochromatin protein 1 0.0157 0.0244 0.033
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0026 0.1916
Echinococcus multilocularis lamin dm0 0.0142 0.0218 0.0223
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0037 0.0104
Plasmodium vivax SET domain protein, putative 0.0029 0.0015 0.0023
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0024 0.0021
Schistosoma mansoni caspase-7 (C14 family) 0.006 0.0071 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0052 0.1179
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0034 0.0681
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0013 0.0009
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0095 0.2399
Schistosoma mansoni RAR-like nuclear receptor 0.013 0.0195 0.0199
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.0129 0.013
Schistosoma mansoni hypothetical protein 0.0218 0.0354 0.0365
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0027 0.0502
Echinococcus multilocularis thyroid hormone receptor alpha 0.013 0.0195 0.0199
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.012 0.3038
Brugia malayi nuclear hormone receptor 0.013 0.0195 0.0263
Schistosoma mansoni inositol monophosphatase 0.0036 0.0027 0.0024
Loa Loa (eye worm) hypothetical protein 0.0069 0.0086 0.0617
Brugia malayi steroid hormone receptor 0.0274 0.0455 0.0621
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0029 0.0556
Schistosoma mansoni hypothetical protein 0.0355 0.06 0.0622
Schistosoma mansoni coup transcription factor 0.013 0.0195 0.0199
Brugia malayi Bromodomain containing protein 0.0032 0.002 0.0021
Brugia malayi chromobox protein homolog 3 0.0088 0.012 0.016
Loa Loa (eye worm) nuclear receptor NHR-67 0.0057 0.0066 0.0462
Loa Loa (eye worm) hypothetical protein 0.0246 0.0404 0.302
Echinococcus granulosus Nuclear hormone receptor HR96 0.0057 0.0066 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0016 0.02
Mycobacterium ulcerans hypothetical protein 0.0035 0.0026 0.1916
Brugia malayi Nuclear hormone receptor family member nhr-49 0.013 0.0195 0.0263
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-1 0.013 0.0195 0.0263
Onchocerca volvulus 0.0035 0.0026 0.0021
Loa Loa (eye worm) intermediate filament protein 0.0142 0.0218 0.1615
Loa Loa (eye worm) hypothetical protein 0.006 0.0071 0.0505
Echinococcus granulosus TGF beta signal transducer SmadC 0.0052 0.0056 0.0054
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0055 0.0061 0.0059
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0014 0.001
Onchocerca volvulus 0.0142 0.0218 0.0214
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0129 0.3262
Loa Loa (eye worm) hypothetical protein 0.0167 0.0263 0.1952
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0026 0.0458
Brugia malayi Calcitonin receptor-like protein seb-1 0.0689 0.12 0.1648
Echinococcus granulosus Smad4 0.0052 0.0056 0.0054
Loa Loa (eye worm) hypothetical protein 0.0035 0.0026 0.016
Onchocerca volvulus 0.023 0.0376 0.0372
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0462
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.013 0.0195 0.0199
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0128 0.0932
Brugia malayi MH1 domain containing protein 0.0052 0.0056 0.0071
Trypanosoma brucei telomerase reverse transcriptase 0.1527 0.2704 1
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0026 0.0009 0.0005
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0026 0.046
Onchocerca volvulus Protein ultraspiracle homolog 0.013 0.0195 0.0191
Echinococcus multilocularis caspase 2 0.006 0.0071 0.007
Loa Loa (eye worm) hypothetical protein 0.0471 0.0808 0.6073
Loa Loa (eye worm) hypothetical protein 0.0088 0.012 0.0876
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0026 0.0095
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0095 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-25 0.013 0.0195 0.0263
Loa Loa (eye worm) MH2 domain-containing protein 0.0761 0.1328 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0015 0.0023
Loa Loa (eye worm) hypothetical protein 0.0072 0.0093 0.0665
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.005 0.0052 0.0099
Brugia malayi Valyl-tRNA synthetase 0.0026 0.0009 0.0006
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0462
Echinococcus multilocularis survival motor neuron protein 1 0.0246 0.0404 0.0418
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0014 0.0017
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0033
Brugia malayi Nuclear hormone receptor-like 1 0.013 0.0195 0.0263
Brugia malayi orphan nuclear receptor NR2E1 0.0057 0.0066 0.0084
Echinococcus granulosus caspase 2 0.006 0.0071 0.007
Loa Loa (eye worm) nuclear factor I 0.0029 0.0014 0.0075
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.013 0.0195 0.0199
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0037 0.0104
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0026 0.0458
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0095 0.0094
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0026 0.0009 0.0006
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0057 0.0066 0.0064
Brugia malayi Steroid receptor seven-up type 2 0.013 0.0195 0.0263
Brugia malayi nuclear receptor RXR 0.0057 0.0066 0.0084
Loa Loa (eye worm) hypothetical protein 0.0072 0.0093 0.0665
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0128 0.0129
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0034 0.0681
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.013 0.0195 0.0199
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0689 0.12 0.9029
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0026 0.0009 0.0005
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0024 0.0021
Brugia malayi nuclear hormone receptor family member odr-7 0.0057 0.0066 0.0084
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.013 0.0195 0.0199
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0129 0.013
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0068 0.0477
Brugia malayi hypothetical protein 0.0057 0.0066 0.0084
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1527 0.2704 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.005 0.0052 0.0066
Schistosoma mansoni chromobox protein 0.0157 0.0244 0.025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0029 0.0556
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0052 0.0056 0.0054
Echinococcus multilocularis Smad4 0.0052 0.0056 0.0054
Loa Loa (eye worm) beta-lactamase 0.0035 0.0026 0.016
Echinococcus granulosus nuclear receptor 2DBD gamma 0.013 0.0195 0.0199
Loa Loa (eye worm) hypothetical protein 0.0284 0.0473 0.3542
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0026 0.016
Echinococcus granulosus chromobox protein 2 0.0026 0.0009 0.0005
Loa Loa (eye worm) hypothetical protein 0.0035 0.0026 0.016
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.004 0.0034 0.0091
Loa Loa (eye worm) hypothetical protein 0.0218 0.0354 0.2642
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0027 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0074 0.1785
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0037 0.0034
Brugia malayi Cell death protein 3 precursor 0.006 0.0071 0.0092
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0069 0.0086 0.0085
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0014 0.0069
Loa Loa (eye worm) hypothetical protein 0.0162 0.0253 0.1877
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.0129 0.013
Loa Loa (eye worm) hypothetical protein 0.0072 0.0093 0.0665
Echinococcus granulosus mothers against decapentaplegic 5 0.0052 0.0056 0.0054
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0129 0.3262
Trichomonas vaginalis chromobox protein, putative 0.0094 0.0132 0.3364
Giardia lamblia GTOR 0.005 0.0052 0.0143
Loa Loa (eye worm) hypothetical protein 0.0069 0.0086 0.0619
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.013 0.0195 0.1442
Schistosoma mansoni Smad4 0.0052 0.0056 0.0054
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0057 0.0066 0.0064
Plasmodium vivax telomerase reverse transcriptase, putative 0.1527 0.2704 1
Echinococcus multilocularis Chromobox protein 3 0.0026 0.0009 0.0005
Loa Loa (eye worm) inositol-1 0.0036 0.0027 0.0173
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1527 0.2704 1
Brugia malayi nuclear receptor RXR 0.0072 0.0093 0.0121
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.013 0.0195 0.0199
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.013 0.0195 0.1442
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0033 0.003
Brugia malayi Muscleblind-like protein 0.0167 0.0263 0.0356
Echinococcus granulosus nuclear receptor nhr 48 0.0057 0.0066 0.0064
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.013 0.0195 0.0199
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0052 0.0056 0.0054
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0095 0.0094
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0026 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.013 0.0195 0.0263
Brugia malayi Nuclear hormone receptor family member nhr-19 0.013 0.0195 0.0263
Brugia malayi Nuclear hormone receptor E75 0.0057 0.0066 0.0084
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0037 0.0766
Loa Loa (eye worm) hypothetical protein 0.0035 0.0026 0.016
Schistosoma mansoni nuclear hormone receptor 0.013 0.0195 0.0199
Onchocerca volvulus 0.0026 0.0009 0.0004
Loa Loa (eye worm) hypothetical protein 0.0029 0.0014 0.0075
Echinococcus granulosus tumor protein p63 0.1104 0.1945 0.2027
Loa Loa (eye worm) steroid hormone receptor 0.0274 0.0455 0.3403
Loa Loa (eye worm) hypothetical protein 0.0142 0.0218 0.1615
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.013 0.0195 0.0199
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0462
Brugia malayi hypothetical protein 0.0072 0.0093 0.0121
Loa Loa (eye worm) hypothetical protein 0.0072 0.0093 0.0665
Trichomonas vaginalis set domain proteins, putative 0.023 0.0376 1
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0129 0.3262
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0462
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.0215 0.022
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0218 0.0354 0.0365
Trichomonas vaginalis chromobox protein, putative 0.0157 0.0244 0.6402
Onchocerca volvulus 0.0162 0.0253 0.0249
Echinococcus granulosus retinoic acid receptor rxr beta a 0.013 0.0195 0.0199
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0027 0.0101
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.013 0.0195 0.0199
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0016 0.02
Loa Loa (eye worm) phosphatidylinositol 3 0.005 0.0052 0.036
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0057 0.0066 0.0064
Onchocerca volvulus 0.0159 0.0249 0.0244
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0011 0.006
Echinococcus granulosus Chromobox protein 3 0.0026 0.0009 0.0005
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.005 0.0052 0.0193
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0095 0.0318
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0462
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0009 0.0042
Onchocerca volvulus 0.0057 0.0066 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0016 0.0186
Schistosoma mansoni survival motor neuron protein 0.005 0.0053 0.0051
Echinococcus granulosus geminin 0.0355 0.06 0.0622
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0072 0.0093 0.0092
Loa Loa (eye worm) hypothetical protein 0.0689 0.12 0.9029
Onchocerca volvulus 0.013 0.0195 0.0191
Brugia malayi Nuclear hormone receptor family member nhr-3 0.013 0.0195 0.0263
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0011 0.006
Echinococcus multilocularis apoptotic protease activating factor 1 0.006 0.0071 0.007
Echinococcus granulosus FTZ F1 alpha 0.013 0.0195 0.0199
Brugia malayi Inositol-1 0.0036 0.0027 0.0032
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0015 0.0011
Schistosoma mansoni Tr4/Tr2 (homologue) 0.013 0.0195 0.0199
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0057 0.0066 0.0064
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.005 0.0052 0.0159
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0011 0.0058
Loa Loa (eye worm) MH1 domain-containing protein 0.0052 0.0056 0.0389
Echinococcus multilocularis microtubule associated protein 2 0.5358 0.9579 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0057 0.0066 0.0064
Loa Loa (eye worm) hypothetical protein 0.0072 0.0093 0.0665
Echinococcus granulosus microtubule associated protein 2 0.5358 0.9579 1
Brugia malayi jmjC domain containing protein 0.0093 0.0129 0.0172
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0026 0.0062
Onchocerca volvulus 0.0069 0.0086 0.0082
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0026 0.0009 0.0005
Schistosoma mansoni cellular tumor antigen P53 0.0162 0.0253 0.026
Onchocerca volvulus 0.0035 0.0026 0.0021
Brugia malayi hypothetical protein 0.0026 0.0009 0.0006
Schistosoma mansoni hypothetical protein 0.0048 0.0049 0.0046
Schistosoma mansoni smad 0.0052 0.0056 0.0054
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0045 0.0982
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.013 0.0195 0.1442
Schistosoma mansoni chromobox protein 0.0026 0.0009 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0034 0.0681
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0029 0.0556
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0095 0.0316
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.005 0.0052 0.005
Loa Loa (eye worm) MH2 domain-containing protein 0.0052 0.0056 0.0389
Brugia malayi latrophilin 2 splice variant baaae 0.0471 0.0808 0.1108
Brugia malayi Latrophilin receptor protein 2 0.0218 0.0354 0.0482
Echinococcus granulosus ecdysone induced protein 78C 0.013 0.0195 0.0199
Onchocerca volvulus 0.0035 0.0026 0.0021
Toxoplasma gondii RNA-directed DNA polymerase 0.1527 0.2704 1
Schistosoma mansoni lamin 0.0142 0.0218 0.0223
Brugia malayi hypothetical protein 0.006 0.0071 0.0092
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0462
Loa Loa (eye worm) hypothetical protein 0.013 0.0195 0.1442
Brugia malayi hypothetical protein 0.0072 0.0093 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-31 0.013 0.0195 0.0263
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0024 0.0021
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.013 0.0195 0.0191
Onchocerca volvulus 0.0055 0.0061 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0021 0.0326
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0024 0.015
Mycobacterium ulcerans lipase LipD 0.0035 0.0026 0.1916
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0128 0.0129
Brugia malayi nuclear hormone receptor 0.0057 0.0066 0.0084
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0015 0.0011
Schistosoma mansoni inositol monophosphatase 0.0036 0.0027 0.0024
Trypanosoma brucei target of rapamycin kinase 3, putative 0.004 0.0034 0.0126
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0033
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.0129 0.0171
Echinococcus multilocularis FTZ F1 alpha 0.013 0.0195 0.0199
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0009 0.0007
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0129 0.013
Echinococcus granulosus nuclear receptor 2DBD gamma 0.013 0.0195 0.0199
Schistosoma mansoni smad1 5 8 and 0.0052 0.0056 0.0054
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0037 0.0766
Loa Loa (eye worm) hypothetical protein 0.006 0.0071 0.0505
Trichomonas vaginalis esterase, putative 0.0035 0.0026 0.0458
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0026 0.046
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0129 0.3262
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0057 0.0066 0.0061
Loa Loa (eye worm) DR-78 0.0057 0.0066 0.0462
Brugia malayi ecdysone receptor 0.0057 0.0066 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0016 0.02
Schistosoma mansoni hypothetical protein 0.006 0.0071 0.007
Brugia malayi nuclear receptor NHR-88 0.0057 0.0066 0.0084
Echinococcus granulosus GPCR family 2 0.0218 0.0354 0.0365
Echinococcus granulosus Nuclear hormone receptor HR96 0.0057 0.0066 0.0064
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0027 0.1538
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.013 0.0195 0.0199
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0053 0.0067
Mycobacterium ulcerans beta-lactamase 0.0035 0.0026 0.1916
Brugia malayi Nuclear hormone receptor family member nhr-19 0.013 0.0195 0.0263
Schistosoma mansoni smad1 5 8 and 0.0052 0.0056 0.0054
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.005 0.0052 0.0193
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0026 0.0022
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0009 0.0007
Mycobacterium tuberculosis Conserved protein 0.0035 0.0026 0.046
Brugia malayi hypothetical protein 0.0246 0.0404 0.0551
Brugia malayi SET domain containing protein 0.0027 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0037
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0026 0.0009 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0052 0.1179
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0129 0.013
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0072 0.0093 0.0092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0015 0.0011
Brugia malayi Associated with TFs and helicases family protein 0.0026 0.0009 0.0006
Brugia malayi MH2 domain containing protein 0.0052 0.0056 0.0071
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0462
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0129 0.0384
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0128 0.0129
Echinococcus granulosus Chromo domain 0.0026 0.0009 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-14 0.013 0.0195 0.0263
Schistosoma mansoni nuclear hormone receptor 0.0057 0.0066 0.0064
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0689 0.12 0.1648
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0037
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.005 0.0052 0.0099
Brugia malayi PHD-finger family protein 0.0028 0.0014 0.0013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0015 0.0011
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0026 0.0022
Leishmania major hypothetical protein, conserved 0.0035 0.0026 0.006
Brugia malayi tailless protein 0.0057 0.0066 0.0084
Loa Loa (eye worm) acetyltransferase 0.014 0.0215 0.159
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0037 0.0104
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0026 0.0458
Schistosoma mansoni hypothetical protein 0.005 0.0053 0.0051
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0462
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0027 0.0006
Echinococcus multilocularis mothers against decapentaplegic 5 0.0052 0.0056 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0074 0.1785
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0014 0.0017
Brugia malayi MH1 domain containing protein 0.0029 0.0014 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0039 0.0823
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0057 0.0066 0.0462
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.005 0.0052 0.3613
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.013 0.0195 0.0263
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0462
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0014 0.0017
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0026 0.046
Brugia malayi Pre-SET motif family protein 0.0029 0.0015 0.0014
Schistosoma mansoni steroid hormone receptor ad4bp 0.013 0.0195 0.0199
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.013 0.0195 0.1442
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.013 0.0195 0.1442
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0129 0.3262
Brugia malayi MH1 domain containing protein 0.0029 0.0014 0.0014
Schistosoma mansoni intermediate filament proteins 0.0142 0.0218 0.0223
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0462
Brugia malayi Smad1 0.0052 0.0056 0.0071
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0026 0.0009 0.0005
Plasmodium falciparum phd finger protein, putative 0.0028 0.0014 0.0017
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0014 0.001
Echinococcus multilocularis GPCR, family 2 0.0218 0.0354 0.0365
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0029 0.0556
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.013 0.0195 0.0199
Echinococcus multilocularis geminin 0.0355 0.06 0.0622
Loa Loa (eye worm) latrophilin receptor protein 2 0.0218 0.0354 0.2642
Onchocerca volvulus 0.0142 0.0218 0.0214
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0057 0.0066 0.0064
Brugia malayi beta-lactamase family protein 0.0035 0.0026 0.0029
Loa Loa (eye worm) hypothetical protein 0.0035 0.0026 0.016
Schistosoma mansoni microtubule-associated protein tau 0.5358 0.9579 1
Brugia malayi M-phase phosphoprotein, mpp8 0.0026 0.0009 0.0006
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0072 0.0093 0.0092
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0128 0.017
Schistosoma mansoni thyroid hormone receptor 0.013 0.0195 0.0199
Loa Loa (eye worm) hypothetical protein 0.0057 0.0066 0.0462
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.005 0.0052 0.005
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0026 0.046

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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