Detailed information for compound 14316

Basic information

Technical information
  • TDR Targets ID: 14316
  • Name: 1-(1H-benzimidazol-2-ylmethyl)-3-prop-1-en-2- ylbenzimidazol-2-one
  • MW: 304.346 | Formula: C18H16N4O
  • H donors: 1 H acceptors: 2 LogP: 2.89 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=C)n1c(=O)n(c2c1cccc2)Cc1nc2c([nH]1)cccc2
  • InChi: 1S/C18H16N4O/c1-12(2)22-16-10-6-5-9-15(16)21(18(22)23)11-17-19-13-7-3-4-8-14(13)20-17/h3-10H,1,11H2,2H3,(H,19,20)
  • InChiKey: KMIRHNWMSSHNGG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(1H-benzimidazol-2-ylmethyl)-3-isopropenyl-benzimidazol-2-one
  • 1-(1H-benzimidazol-2-ylmethyl)-3-isopropenyl-2-benzimidazolone
  • 1-(1H-benzimidazol-2-ylmethyl)-3-prop-1-en-2-yl-benzimidazol-2-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus excitatory amino acid transporter 2 0.0123 0.1152 0.1152
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0186 0.1332
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.1093 1
Echinococcus multilocularis tumor protein p63 0.0335 0.3403 0.3403
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.004 0.0279 0.3048
Leishmania major DNA polymerase kappa, putative 0.0021 0.0068 0.0593
Mycobacterium tuberculosis Possible hydrolase 0.0018 0.0039 0.0317
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0317 0.3213 0.3213
Loa Loa (eye worm) hypothetical protein 0.0077 0.0668 0.0981
Loa Loa (eye worm) hypothetical protein 0.0038 0.0258 0.0378
Mycobacterium tuberculosis Probable oxidoreductase 0.0129 0.1221 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0147 0.0221
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0258 0.0258
Brugia malayi 6-phosphofructokinase 0.0117 0.1093 0.1645
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.027 0.2474
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0215 0.0315
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0147 0.0147
Schistosoma mansoni DNA helicase recq1 0.0039 0.0261 0.0606
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0068 0.0624
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.0001
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0258 0.0598
Loa Loa (eye worm) doublecortin family protein 0.002 0.0065 0.0096
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.0258 0.0598
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0057
Trichomonas vaginalis set domain proteins, putative 0.0729 0.7581 1
Schistosoma mansoni phospholipase A-2-activating protein 0.0024 0.0101 0.0235
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0186 0.1333
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.001
Chlamydia trachomatis neutral amino acid transporter 0.0054 0.0427 0.3496
Echinococcus multilocularis expressed protein 0.0748 0.778 0.778
Echinococcus multilocularis nmda type glutamate receptor 0.0029 0.0153 0.0153
Echinococcus multilocularis cysteine protease 0.0018 0.0042 0.0042
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0116 0.1083 0.8809
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0129 0.1221 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.0038 0.0258 0.0258
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0117 0.1093 0.8892
Loa Loa (eye worm) hypothetical protein 0.0038 0.0248 0.0364
Schistosoma mansoni lipoxygenase 0.002 0.0065 0.0152
Trichomonas vaginalis mucin-desulfating sulfatase, putative 0.0018 0.0039 0.0001
Trichomonas vaginalis phospholipase A-2-activating protein, putative 0.0035 0.0223 0.0246
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.006 0.0198
Trichomonas vaginalis rotamase, putative 0.0034 0.0215 0.0235
Echinococcus multilocularis thyroid hormone receptor alpha 0.0282 0.2843 0.2843
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0028 0.0147 0.0215
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0038 0.0327
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0007 0.001
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0229 0.053
Mycobacterium tuberculosis Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0018 0.0039 0.0317
Schistosoma mansoni polycystin 1-related 0.002 0.0065 0.0152
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0018 0.0039 0.0002
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0038 0.0344
Loa Loa (eye worm) hypothetical protein 0.003 0.0172 0.0252
Trichomonas vaginalis rotamase, putative 0.0034 0.0206 0.0223
Trypanosoma brucei WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative 0.0024 0.0101 0.0927
Trichomonas vaginalis DNA helicase recq, putative 0.0044 0.0318 0.0372
Chlamydia trachomatis glutamine binding protein 0.0021 0.0068 0.0272
Schistosoma mansoni alkaline phosphatase 0.0317 0.3213 0.7454
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0042 0.0005
Schistosoma mansoni hypothetical protein 0.0174 0.1698 0.3939
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.0001
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0038 0.0258 0.0378
Brugia malayi hypothetical protein 0.0036 0.0229 0.0344
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0186 0.1333
Echinococcus granulosus Excitatory amino acid transporter 0.0123 0.1152 0.1152
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0038 0.0258 0.0292
Echinococcus granulosus lamin dm0 0.0081 0.0707 0.0707
Trichomonas vaginalis DNA helicase recq, putative 0.0065 0.0538 0.0663
Brugia malayi PXA domain containing protein 0.0038 0.0258 0.0388
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0147 0.0215
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0555 0.0835
Echinococcus granulosus collagen alpha 1VII chain 0.0018 0.0039 0.0039
Entamoeba histolytica recQ family DNA helicase 0.002 0.006 0.0546
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0092 0.0831 0.1927
Treponema pallidum glutamate transporter 0.0054 0.0427 0.0713
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0038 0.0344
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0057
Echinococcus multilocularis bloom syndrome protein 0.0065 0.0538 0.0538
Brugia malayi steroid hormone receptor 0.0028 0.0147 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.0001
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0147 0.0147
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0147 0.0147
Echinococcus granulosus voltage dependent calcium channel subunit 0.0435 0.4467 0.4467
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0042 0.0065
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0018 0.0039 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0042 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0038 0.0344
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0015 0.0008 0.0012
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0147 0.0147
Schistosoma mansoni lamin 0.0081 0.0707 0.164
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.006 0.0139
Schistosoma mansoni rab6-interacting 0.002 0.0065 0.0152
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0232 0.2125
Loa Loa (eye worm) hypothetical protein 0.0028 0.0147 0.0215
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0015 0.0007 0.001
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0038 0.0344
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.1151 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0038 0.0038
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0317 0.3213 0.3213
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.027 0.2215
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0065 0.0249
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.027 0.0407
Brugia malayi von Willebrand factor type A domain containing protein 0.0018 0.0039 0.0058
Loa Loa (eye worm) glutathione reductase 0.0051 0.0391 0.0574
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0391 0.0391
Brugia malayi Intermediate filament tail domain containing protein 0.0081 0.0707 0.1064
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0147 0.0215
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0579 0.5303
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0042 0.0005
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0579 0.5303
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0275 0.2516
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.0065 0.0076
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0275 0.2516
Schistosoma mansoni glutamate receptor NMDA 0.0021 0.007 0.0163
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.1093 0.1604
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0077 0.0668 0.795
Echinococcus multilocularis neutral amino acid transporter A 0.0123 0.1152 0.1152
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.0001
Leishmania major cathepsin L-like protease 0.0018 0.0042 0.0363
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0042 0.0044
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0039 0.0261 0.0261
Echinococcus granulosus metabotropic glutamate receptor 5 0.0117 0.109 0.109
Echinococcus multilocularis RUN 0.002 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0039 0.0264 0.0387
Brugia malayi von Willebrand factor type A domain containing protein 0.0018 0.0039 0.0058
Giardia lamblia Hypothetical protein 0.0018 0.0039 0.0045
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0116 0.1083 0.8873
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0042 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0147 0.0215
Treponema pallidum 76K protein 0.0018 0.0039 0.0002
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0317 0.3213 0.3213
Echinococcus multilocularis neutral amino acid transporter A 0.0123 0.1152 0.1152
Loa Loa (eye worm) excitatory amino acid transporter 0.0123 0.1152 0.1691
Trichomonas vaginalis ap endonuclease, putative 0.004 0.027 0.0309
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.0258 0.0258
Brugia malayi hypothetical protein 0.0016 0.0021 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.0001
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.1151 0.267
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0275 0.2516
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0258 0.0598
Loa Loa (eye worm) hypothetical protein 0.0478 0.4913 0.7214
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0123 0.1152 0.151
Echinococcus multilocularis musashi 0.0081 0.0707 0.0707
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0038 0.0308
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0206 0.1885
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0077 0.0668 0.5216
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0042 0.0005
Loa Loa (eye worm) hypothetical protein 0.0046 0.0337 0.0494
Leishmania major ATP-dependent phosphofructokinase 0.0117 0.1093 0.9494
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0275 0.2516
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.1093 0.1604
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0261 0.2007
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0258 0.0292
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0555 0.4818
Echinococcus granulosus leukotriene A 4 hydrolase 0.0239 0.2384 0.2384
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0123 0.1152 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0022 0.0199
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0129 0.1221 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0092 0.0831 0.0831
Echinococcus multilocularis excitatory amino acid transporter 3 0.0123 0.1152 0.1152
Onchocerca volvulus 0.0028 0.0147 0.0183
Echinococcus granulosus intermediate filament protein 0.0081 0.0707 0.0707
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0186 0.0272
Loa Loa (eye worm) WD domain-containing protein 0.0024 0.0101 0.0149
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0028 0.0143 0.021
Mycobacterium ulcerans endonuclease IV 0.0077 0.0668 0.5662
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.0258 0.0258
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0147 0.0147
Echinococcus multilocularis Regulator of G protein signaling 20 0.0038 0.0258 0.0258
Loa Loa (eye worm) fibroinase 0.0018 0.0042 0.0061
Onchocerca volvulus 0.0018 0.0042 0.0044
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0232 0.0258
Loa Loa (eye worm) hypothetical protein 0.0039 0.0261 0.0383
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0147 0.0221
Onchocerca volvulus 0.0081 0.0707 0.0923
Entamoeba histolytica hypothetical protein 0.0018 0.0039 0.0356
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0147 0.0147
Echinococcus multilocularis cpg binding protein 0.0031 0.0181 0.0181
Onchocerca volvulus 0.0018 0.0039 0.0041
Onchocerca volvulus 0.0729 0.7581 1
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0206 0.1885
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0123 0.1152 0.2671
Entamoeba histolytica recQ family helicase, putative 0.0044 0.0318 0.2914
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0021 0.0068 0.0272
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0258 0.0292
Schistosoma mansoni rotamase 0.0034 0.0215 0.0498
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0042 0.0005
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0232 0.0232
Brugia malayi von Willebrand factor type A domain containing protein 0.0018 0.0039 0.0058
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0391 0.4454
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0042 0.0061
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0018 0.0039 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0831 0.1927
Onchocerca volvulus 0.0478 0.4913 0.6477
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0057
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0038 0.0344
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0028 0.0143 0.021
Loa Loa (eye worm) CUTiclin-Like family member 0.0018 0.0039 0.0057
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0042 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0147 0.0221
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0057
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0007 0.001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0038 0.0344
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.027 0.2474
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0391 0.3201
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0147 0.0221
Leishmania major cathepsin L-like protease 0.0069 0.0579 0.5035
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0057
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0186 0.1332
Mycobacterium tuberculosis Probable sulfatase 0.0018 0.0039 0.0317
Brugia malayi hypothetical protein 0.011 0.1015 0.1528
Loa Loa (eye worm) runx1 0.006 0.0485 0.0713
Leishmania major hypothetical protein, conserved 0.0025 0.0115 0.1003
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0019 0.0052 0.0178
Brugia malayi von Willebrand Factor 0.0018 0.0039 0.0058
Echinococcus granulosus intestinal type alkaline phosphatase 0.0317 0.3213 0.3213
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.0001
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0039 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.0028 0.0147 0.0215
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0641 0.6643 0.9755
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.0001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0057
Schistosoma mansoni lipoxygenase 0.0057 0.0452 0.1049
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.027 0.2091
Leishmania major cathepsin L-like protease 0.0018 0.0042 0.0363
Loa Loa (eye worm) hypothetical protein 0.0028 0.0147 0.0215
Schistosoma mansoni serine-rich repeat protein 0.0225 0.2235 0.5184
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0258 0.0292
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0007 0.0016
Brugia malayi Receptor family ligand binding region containing protein 0.0028 0.0143 0.0215
Onchocerca volvulus 0.002 0.0065 0.0076
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0232 0.2125
Entamoeba histolytica elongation factor-2 kinase, putative 0.0018 0.0039 0.0356
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0958 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0115 0.1234
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0029 0.0153 0.0153
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0123 0.1152 0.1152
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0042 0.0005
Brugia malayi hypothetical protein 0.0018 0.0039 0.0058
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0232 0.2125
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0579 0.5303
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0088 0.0788 0.0788
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0258 0.0598
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0057
Treponema pallidum glutamate/aspartate transporter 0.0054 0.0427 0.0713
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0258 0.0292
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0042 0.0005
Giardia lamblia Sgs1 DNA helicase, putative 0.0039 0.0261 0.9602
Brugia malayi Cytochrome P450 family protein 0.0047 0.035 0.0526
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0275 0.2516
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0042 0.0097
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.1093 1
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0021 0.0068 0.0056
Echinococcus multilocularis alkaline phosphatase 0.0317 0.3213 0.3213
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0147 0.0183
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0123 0.1151 0.1151
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.001
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0021 0.007 0.007
Chlamydia trachomatis endonuclease IV 0.0077 0.0668 0.5659
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0186 0.1702
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0042 0.0042
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0123 0.1152 0.9433
Chlamydia trachomatis glutamate symporter 0.0123 0.1152 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0015 0.0007 0.0007
Brugia malayi Pre-SET motif family protein 0.0641 0.6643 1
Echinococcus granulosus dnaJ subfamily B 0.0421 0.431 0.431
Schistosoma mansoni hypothetical protein 0.0254 0.2547 0.5908
Loa Loa (eye worm) phosphofructokinase 0.0117 0.1093 0.1604
Loa Loa (eye worm) hypothetical protein 0.0038 0.0258 0.0378
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0831 0.1927
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.0258 0.0388
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.1093 0.1399
Loa Loa (eye worm) hypothetical protein 0.0024 0.0101 0.0149
Onchocerca volvulus 0.0018 0.0039 0.0041
Plasmodium vivax glutathione reductase, putative 0.0051 0.0391 0.4454
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0275 0.0315
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.0516 0.4724
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0254 0.2547 0.2547
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.0001
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0147 0.0221
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.027 0.3692
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0579 0.5303
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.1093 0.2535
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0147 0.034
Leishmania major cathepsin L-like protease 0.0069 0.0579 0.5035
Echinococcus granulosus lamin 0.0081 0.0707 0.0707
Plasmodium falciparum glutathione reductase 0.0051 0.0391 0.5603
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.001
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0258 0.0598
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0186 0.1333
Schistosoma mansoni metabotropic glutamate receptor 0.0081 0.0708 0.1642
Schistosoma mansoni DNA helicase recq5 0.0039 0.0261 0.0606
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.0001
Echinococcus granulosus excitatory amino acid transporter 3 0.0123 0.1152 0.1152
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0042 0.0065
Trichomonas vaginalis DNA helicase recq1, putative 0.0065 0.0538 0.0663
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.037 0.0859
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0042 0.0005
Brugia malayi hypothetical protein 0.0252 0.2521 0.3795
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0042 0.0097
Brugia malayi Excitatory amino acid transporter 0.0123 0.1152 0.1733
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0044 0.0318 0.2766
Schistosoma mansoni hypothetical protein 0.0225 0.2235 0.5184
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0018 0.0039 0.0057
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0186 0.0197
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0435 0.4467 0.4467
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0147 0.034
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0038 0.0327
Schistosoma mansoni ap endonuclease 0.004 0.027 0.0627
Echinococcus granulosus nmda type glutamate receptor 0.0029 0.0153 0.0153
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0018 0.0039 0.0057
Echinococcus multilocularis dnaJ subfamily B 0.0421 0.431 0.431
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.1093 1
Brugia malayi hypothetical protein 0.0038 0.0258 0.0388
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0258 0.0598
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0275 0.0315
Loa Loa (eye worm) hypothetical protein 0.002 0.006 0.0088
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0261 0.2007
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0038 0.0327
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0115 0.0981
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.1093 0.2535
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0042 0.0061
Brugia malayi 6-phosphofructokinase 0.0117 0.1093 0.1645
Loa Loa (eye worm) hypothetical protein 0.0038 0.0258 0.0378
Loa Loa (eye worm) hypothetical protein 0.0193 0.1894 0.2781
Toxoplasma gondii microneme protein MIC2 0.0018 0.0039 0.0011
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0834 0.8693 0.8693
Mycobacterium ulcerans hypothetical protein 0.002 0.0065 0.0249
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.1151 0.267
Echinococcus multilocularis phospholipase A 2 activating protein 0.0035 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0028 0.0147 0.0215
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0275 0.2516
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0044 0.0318 0.2914
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0038 0.0258 0.0388
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0452 0.0452
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0579 0.5303
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0391 0.0391
Loa Loa (eye worm) hypothetical protein 0.0478 0.4913 0.7214
Schistosoma mansoni inositol monophosphatase 0.0036 0.0232 0.0539
Onchocerca volvulus 0.0018 0.0042 0.0044
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.027 0.0426
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0147 0.0147
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0232 0.2125
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0018 0.0039 0.0019
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0018 0.0039 0.0039
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0018 0.0039 0.0015
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0042 0.0005
Schistosoma mansoni inositol monophosphatase 0.0036 0.0232 0.0539
Echinococcus granulosus alkaline phosphatase 0.0317 0.3213 0.3213
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0239 0.2384 0.5531
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0115 0.1056
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0258 0.0258
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0147 0.0221
Mycobacterium ulcerans epimerase 0.002 0.0065 0.0249
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0059 0.0481 0.7029
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0147 0.0221
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0116 0.1083 0.8873
Echinococcus granulosus excitatory amino acid transporter 2 0.0123 0.1152 0.1152
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0042 0.0005
Brugia malayi phosphofructokinase 0.0117 0.1093 0.1645
Echinococcus granulosus Excitatory amino acid transporter 0.0123 0.1152 0.1152
Echinococcus granulosus neutral amino acid transporter A 0.0123 0.1152 0.1152
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0232 0.0258
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0065 0.0065
Plasmodium vivax thrombospondin-related anonymous protein 0.0018 0.0039 0.0015
Loa Loa (eye worm) hypothetical protein 0.0028 0.0147 0.0215
Loa Loa (eye worm) CUTiclin family member 0.0018 0.0039 0.0057
Brugia malayi Doublecortin family protein 0.002 0.0065 0.0098
Echinococcus granulosus Regulator of G protein signaling 20 0.0038 0.0258 0.0258
Plasmodium falciparum thrombospondin-related anonymous protein 0.0018 0.0039 0.0019
Schistosoma mansoni axis inhibition protein axin 0.0038 0.0258 0.0598
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0065 0.0536
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0147 0.0221
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0054 0.0427 0.0991
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0147 0.0221
Brugia malayi nuclear receptor RXR 0.0015 0.0007 0.001
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.027 1
Plasmodium vivax vivapain-2 0.0018 0.0042 0.0052
Brugia malayi hypothetical protein 0.0015 0.0007 0.001
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0021 0.007 0.007
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0555 0.5075
Mycobacterium ulcerans arylsulfatase, AslA 0.0018 0.0039 0.0009
Loa Loa (eye worm) hypothetical protein 0.0028 0.0143 0.021
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0147 0.0221
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0147 0.0215
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0057
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0147 0.034
Entamoeba histolytica cysteine protease, putative 0.0018 0.0042 0.0382
Loa Loa (eye worm) hypothetical protein 0.0025 0.0115 0.0169
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0275 0.2516
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0275 0.2516
Leishmania major cathepsin L-like protease 0.0018 0.0042 0.0363
Loa Loa (eye worm) PXA domain-containing protein 0.0038 0.0258 0.0378
Brugia malayi Cathepsin L-like precursor 0.0018 0.0042 0.0063
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.0258 0.0258
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0042 0.0005
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0258 0.0258
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0021 0.0068 0.0272
Mycobacterium ulcerans hydrolase 0.0018 0.0039 0.0009
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0038 0.0258 0.0378
Brugia malayi PXA domain containing protein 0.0038 0.0258 0.0388
Entamoeba histolytica hypothetical protein 0.0023 0.0094 0.0857
Brugia malayi hypothetical protein 0.0015 0.0007 0.001
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0147 0.0147
Echinococcus granulosus RUN 0.002 0.0065 0.0065
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0555 0.5075
Mycobacterium ulcerans 6-phosphofructokinase 0.0117 0.1093 0.9477
Brugia malayi Bloom's syndrome protein homolog 0.0065 0.0538 0.081
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0186 0.6374
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0065 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0022 0.0199
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0092 0.0831 0.7122
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0042 0.0382
Schistosoma mansoni metabotropic glutamate receptor 0.0049 0.0368 0.0853
Onchocerca volvulus 0.0018 0.0039 0.0041
Schistosoma mansoni hypothetical protein 0.0421 0.431 1
Echinococcus granulosus glutamate receptor 2 0.0021 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0057
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0254 0.2547 0.2547
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0057
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0039 0.0264 0.0264
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0147 0.034
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0065 0.0065
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0038 0.0344
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0579 0.5303
Echinococcus multilocularis lamin dm0 0.0081 0.0707 0.0707
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0042 0.0005
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0038 0.0258 0.0258
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0044 0.0318 0.2914
Brugia malayi von Willebrand factor type A domain containing protein 0.0018 0.0039 0.0058
Brugia malayi regulator of G-protein signaling rgs-7 0.0038 0.0258 0.0388
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0039 0.0261 0.3545
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0021 0.007 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.0001
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0275 0.2131
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0054 0.0427 0.0427
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0038 0.0344
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.0258 0.0598
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.0258 0.0258
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0147 0.0147
Trypanosoma brucei unspecified product 0.0034 0.0207 0.1892
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0232 0.2018
Schistosoma mansoni hypothetical protein 0.0015 0.0008 0.0019
Brugia malayi ecdysteroid receptor 0.0028 0.0147 0.0221
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0042 0.0005
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0206 0.1885
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0092 0.0831 0.0831
Entamoeba histolytica hypothetical protein 0.0038 0.0258 0.2357
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0258 0.0258
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.0533 0.5497 1
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0042 0.0382
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.0096
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0186 0.0197
Brugia malayi von Willebrand factor type A domain containing protein 0.0018 0.0039 0.0058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0042 0.0005
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.027 0.2089
Onchocerca volvulus 0.0081 0.0707 0.0923
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0042 0.0042
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0115 0.1056
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.001
Brugia malayi Zona pellucida-like domain containing protein 0.0018 0.0039 0.0058
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0186 0.1871
Entamoeba histolytica hypothetical protein 0.0036 0.0229 0.2093
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0192 0.1575
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0239 0.2384 0.3501
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0261 0.0393
Brugia malayi Pre-SET motif family protein 0.0092 0.0831 0.125
Brugia malayi nuclear hormone receptor 0.0028 0.0147 0.0221
Brugia malayi intermediate filament protein 0.0081 0.0707 0.1064
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0042 0.0005
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.027 0.2349
Schistosoma mansoni hypothetical protein 0.0165 0.1598 0.3706
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0065 0.0065
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0083 0.0731 0.11
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0018 0.0039 0.0015
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0057
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0207 0.1892
Echinococcus multilocularis excitatory amino acid transporter 2 0.0123 0.1152 0.1152
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0038 0.0057
Loa Loa (eye worm) RGS-3 protein 0.0038 0.0258 0.0378
Schistosoma mansoni lozenge 0.006 0.0485 0.1126
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.027 0.2474
Entamoeba histolytica recQ family helicase, putative 0.0019 0.0052 0.0474
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0275 0.2516
Brugia malayi Cathepsin L-like precursor 0.0018 0.0042 0.0063
Loa Loa (eye worm) cytochrome P450 family protein 0.0047 0.035 0.0513
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.0001
Schistosoma mansoni intermediate filament proteins 0.0081 0.0707 0.164
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0147 0.0183
Plasmodium vivax hypothetical protein, conserved 0.0018 0.0039 0.0015
Brugia malayi Cathepsin L-like precursor 0.0018 0.0042 0.0063
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.1151 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0015 0.0007 0.0016
Echinococcus granulosus neutral amino acid transporter A 0.0123 0.1152 0.1152
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0186 0.0197
Echinococcus multilocularis GPCR, family 3, C terminal 0.0015 0.0008 0.0008
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0092 0.0831 0.0831
Trichomonas vaginalis phospholipase A-2-activating protein, putative 0.0024 0.0101 0.0084
Echinococcus multilocularis expressed protein 0.0034 0.0215 0.0215
Brugia malayi Cathepsin L-like precursor 0.0018 0.0042 0.0063
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0057
Brugia malayi Thioredoxin reductase 0.0051 0.0391 0.0588
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.027 0.027
Schistosoma mansoni alkaline phosphatase 0.0317 0.3213 0.7454
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0042 0.0005
Brugia malayi A-kinase anchor protein 10, precursor 0.0038 0.0258 0.0388
Entamoeba histolytica hypothetical protein, conserved 0.0018 0.0039 0.0356
Onchocerca volvulus 0.0018 0.0042 0.0044
Giardia lamblia DINP protein human, muc B family 0.0021 0.0068 0.1314
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0275 0.2131
Giardia lamblia Hypothetical protein 0.0018 0.0039 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0147 0.0221
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0015 0.0008 0.0012
Echinococcus multilocularis lamin 0.0081 0.0707 0.0707
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0206 0.1885
Schistosoma mansoni axis inhibition protein axin 0.0038 0.0258 0.0598
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0555 0.1286
Trypanosoma brucei trypanothione reductase 0.0051 0.0391 0.3576
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0042 0.0005
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0186 0.2354
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0579 0.5303
Brugia malayi WD domain containing protein 0.0035 0.0223 0.0336
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0021 0.007 0.007
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0038 0.0258 0.0258
Brugia malayi metabotropic glutamate receptor type 2 0.0049 0.0368 0.0553
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0215 0.0235
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0164 0.024
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0229 0.0229
Brugia malayi cytoplasmic intermediate filament protein 0.0043 0.0309 0.0465
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0232 0.1747
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0116 0.1083 0.8873
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0042 0.0005
Loa Loa (eye worm) hypothetical protein 0.0117 0.109 0.1601
Brugia malayi follicle stimulating hormone receptor 0.0257 0.2577 0.3879
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0021 0.0068 0.0556
Echinococcus granulosus 6 phosphofructokinase 0.0117 0.1093 0.1093
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0054 0.0427 0.0427
Echinococcus multilocularis excitatory amino acid transporter 2 0.0123 0.1152 0.1152
Onchocerca volvulus 0.0018 0.0042 0.0044
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0042 0.0065
Brugia malayi CXXC zinc finger family protein 0.003 0.0164 0.0246
Echinococcus granulosus dna polymerase kappa 0.004 0.0275 0.0275
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.0001
Brugia malayi von Willebrand factor type A domain containing protein 0.0018 0.0039 0.0058
Loa Loa (eye worm) inositol-1 0.0036 0.0232 0.0341
Mycobacterium tuberculosis Probable reductase 0.0116 0.1083 0.8873
Schistosoma mansoni thyroid hormone receptor 0.0282 0.2843 0.6596
Echinococcus multilocularis geminin 0.0174 0.1698 0.1698
Onchocerca volvulus 0.0049 0.037 0.0478
Brugia malayi hypothetical protein 0.0025 0.0115 0.0174
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0261 0.0393
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0186 0.0197
Schistosoma mansoni hypothetical protein 0.0174 0.1698 0.3939
Brugia malayi hypothetical protein 0.0018 0.0039 0.0058
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0258 0.0258
Brugia malayi Inositol-1 0.0036 0.0232 0.035
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.027 0.2935
Toxoplasma gondii aldehyde dehydrogenase 0.0123 0.1151 1
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0172 0.1572
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.004 0.0271 0.2099
Trichomonas vaginalis ap endonuclease, putative 0.004 0.027 0.0309
Loa Loa (eye worm) hypothetical protein 0.0018 0.0042 0.0061
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0391 0.0574
Brugia malayi Sulfatase family protein 0.0018 0.0039 0.0058
Treponema pallidum ATP-dependent DNA helicase 0.002 0.006 0.004
Echinococcus granulosus phospholipase A 2 activating protein 0.0035 0.0223 0.0223
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.1093 1
Mycobacterium ulcerans sulfatase 0.0018 0.0039 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.0001
Loa Loa (eye worm) hypothetical protein 0.0038 0.0258 0.0378
Schistosoma mansoni rab6-interacting 0.002 0.0065 0.0152
Echinococcus multilocularis regulator of G protein signaling 0.0038 0.0258 0.0258
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0039 0.0261 0.0261
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0038 0.0258 0.0378
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.0001
Echinococcus granulosus axis inhibition protein axin 0.0038 0.0258 0.0258
Plasmodium vivax vivapain-2 0.0018 0.0042 0.0052
Onchocerca volvulus 0.0018 0.0039 0.0041
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0065 0.035
Loa Loa (eye worm) hypothetical protein 0.0079 0.0691 0.1015
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0021 0.007 0.007
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0215 0.0323
Loa Loa (eye worm) hypothetical protein 0.0081 0.0707 0.1038
Echinococcus multilocularis dna polymerase kappa 0.004 0.0275 0.0275
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0147 0.0221
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0018 0.0039 0.0015
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0038 0.0087
Onchocerca volvulus 0.0018 0.0042 0.0044
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0317 0.3213 0.3213
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0555 0.5075
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0117 0.1093 0.1933
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0022 0.0199
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0232 0.0232
Schistosoma mansoni hypothetical protein 0.0018 0.0039 0.009
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0116 0.1083 0.8873
Brugia malayi Cathepsin L-like precursor 0.0018 0.0042 0.0063
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0042 0.0044
Toxoplasma gondii PUL domain-containing protein 0.0035 0.0223 0.1664
Entamoeba histolytica hypothetical protein 0.0038 0.0258 0.2357
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0579 0.5303
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0068 0.0593
Brugia malayi regulator of G-protein signaling egl-10 0.0038 0.0258 0.0388
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0021 0.007 0.007
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0115 0.1056
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0258 0.0598
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0579 0.5303
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0275 0.2516
Echinococcus multilocularis 6 phosphofructokinase 0.0117 0.1093 0.1093
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0232 0.1748
Leishmania major hypothetical protein, conserved 0.0035 0.0223 0.1937
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0317 0.3213 0.3213
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0038 0.0344
Onchocerca volvulus 0.003 0.0164 0.0205
Echinococcus granulosus metabotropic glutamate receptor 2 0.0081 0.0708 0.0708
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.0001
Leishmania major cathepsin L-like protease 0.0018 0.0042 0.0363
Loa Loa (eye worm) intermediate filament protein 0.0081 0.0707 0.1038
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0275 0.2516
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0021 0.0068 0.0056
Brugia malayi von Willebrand factor type A domain containing protein 0.0018 0.0039 0.0058
Loa Loa (eye worm) hypothetical protein 0.0038 0.0248 0.0364
Plasmodium falciparum polyubiquitin binding protein, putative 0.0035 0.0223 0.2939
Echinococcus granulosus bloom syndrome protein 0.0065 0.0538 0.0538
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0391 0.3576
Brugia malayi Cathepsin L-like precursor 0.0018 0.0042 0.0063
Toxoplasma gondii cathepsin CPL 0.0018 0.0042 0.0037
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0039 0.0261 0.0261
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0579 0.5303
Trichomonas vaginalis Phosphoglycerol transferase I, putative 0.0018 0.0039 0.0001
Entamoeba histolytica hypothetical protein, conserved 0.0018 0.0039 0.0356
Toxoplasma gondii exonuclease III APE 0.004 0.027 0.2091
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0117 0.109 0.109
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0147 0.0221
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0258 0.0258
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0147 0.034
Loa Loa (eye worm) hypothetical protein 0.0092 0.0831 0.122
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0275 0.2516
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0147 0.0221
Mycobacterium ulcerans arylsulfatase AtsD 0.0018 0.0039 0.0009
Loa Loa (eye worm) ctsf protein 0.0018 0.0042 0.0061
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0239 0.2384 0.2384
Brugia malayi Zona pellucida-like domain containing protein 0.0018 0.0039 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0147 0.0215
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0123 0.1151 0.9429
Entamoeba histolytica hypothetical protein 0.0038 0.0258 0.2357
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0186 0.0197
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0057
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.027 0.027
Onchocerca volvulus 0.0018 0.0042 0.0044
Onchocerca volvulus 0.002 0.0065 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.0001
Loa Loa (eye worm) glutamate receptor 0.0036 0.0233 0.0342
Echinococcus multilocularis Protein lozenge 0.006 0.0485 0.0485
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0115 0.0699
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0068 0.0559
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0211 0.2082 0.4831
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0021 0.007 0.007
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0081 0.0707 0.1038
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0479 0.3969
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0104 0.0955 0.2216
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0147 0.034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0579 0.5303
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0232 0.1748
Mycobacterium tuberculosis Probable dehydrogenase 0.0116 0.1083 0.8873
Brugia malayi glutathione reductase 0.0051 0.0391 0.0588
Schistosoma mansoni blooms syndrome DNA helicase 0.0045 0.0329 0.0762
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.0831 0.1927
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0038 0.0327
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0042 0.0042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0147 0.0215
Loa Loa (eye worm) hypothetical protein 0.002 0.0065 0.0096
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0555 0.5075
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.0001
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.1093 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0043 0.0309 0.0454
Brugia malayi Metabotropic glutamate receptor precursor. 0.0096 0.0866 0.1303
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0147 0.0147
Onchocerca volvulus 0.0018 0.0042 0.0044
Schistosoma mansoni z-protein (S1r protein) 0.0038 0.0258 0.0598
Entamoeba histolytica hypothetical protein 0.0036 0.0229 0.2093
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0042 0.0063
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0077 0.0668 0.1005
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.1093 0.1399
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0147 0.0147
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0206 0.179
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0555 0.0555
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0147 0.034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0042 0.0005
Echinococcus multilocularis cysteine protease 0.0018 0.0042 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.0001
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0186 0.0197
Treponema pallidum hypothetical protein 0.0018 0.0039 0.0002
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0147 0.0147
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0418 0.4278 0.9925
Loa Loa (eye worm) hypothetical protein 0.0038 0.0258 0.0378
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0258 0.0292
Schistosoma mansoni hypothetical protein 0.0036 0.0229 0.053
Trypanosoma cruzi cruzipain precursor, putative 0.0069 0.0579 0.5303
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0579 0.5303
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0021 0.007 0.007
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0258 0.0598
Echinococcus granulosus GPCR family 3 C terminal 0.0015 0.0008 0.0008
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0042 0.0042
Brugia malayi von Willebrand factor type A domain containing protein 0.0018 0.0039 0.0058
Entamoeba histolytica hypothetical protein 0.0036 0.0229 0.2093
Brugia malayi hypothetical protein 0.002 0.0065 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0042 0.0005
Echinococcus granulosus cpg binding protein 0.0031 0.0181 0.0181
Toxoplasma gondii thioredoxin reductase 0.0051 0.0391 0.3172
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0172 0.1572
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0147 0.034
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0147 0.0147
Mycobacterium ulcerans arylsulfatase AtsB 0.0018 0.0039 0.0009
Schistosoma mansoni coup transcription factor 0.0028 0.0147 0.034
Toxoplasma gondii endonuclease IV APN 0.0077 0.0668 0.5662
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0065 0.0065
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0038 0.0344
Loa Loa (eye worm) RecQ helicase 0.0065 0.0538 0.079
Echinococcus granulosus axis inhibition protein axin 0.0038 0.0258 0.0258
Plasmodium falciparum thioredoxin reductase 0.0051 0.0391 0.5603
Loa Loa (eye worm) hypothetical protein 0.0049 0.037 0.0544
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.0001
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0123 0.1152 0.1152
Schistosoma mansoni hypothetical protein 0.0018 0.0039 0.009
Echinococcus granulosus tumor protein p63 0.0335 0.3403 0.3403
Schistosoma mansoni cpg binding protein 0.003 0.0164 0.0379
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0077 0.0668 1
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0038 0.0258 0.0598
Echinococcus granulosus expressed protein 0.0034 0.0215 0.0215
Leishmania major cathepsin L-like protease 0.0069 0.0579 0.5035
Schistosoma mansoni cpg binding protein 0.0031 0.0181 0.0421
Plasmodium vivax SET domain protein, putative 0.0092 0.0831 1
Echinococcus multilocularis neutral amino acid transporter A 0.0123 0.1152 0.1152
Leishmania major trypanothione reductase 0.0051 0.0391 0.3395
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0042 0.0363
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0117 0.1093 0.8951
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0057
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0039 0.0261 0.0261
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0147 0.0221
Onchocerca volvulus 0.0092 0.0831 0.1086
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0065 0.044
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0258 0.0292
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0018 0.0039 0.0019
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0129 0.1221 1
Echinococcus granulosus geminin 0.0174 0.1698 0.1698
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0579 0.5303
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.1093 0.1399
Mycobacterium tuberculosis Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0018 0.0039 0.0317
Schistosoma mansoni loxhd1 0.002 0.0065 0.0152
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0018 0.0039 0.004
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0038 0.0344
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0147 0.0183
Echinococcus multilocularis glutamate receptor 2 0.0021 0.007 0.007
Brugia malayi Immunoglobulin I-set domain containing protein 0.0018 0.0039 0.0058
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0081 0.0708 0.0708
Echinococcus multilocularis Excitatory amino acid transporter 0.0123 0.1152 0.1152
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0042 0.0042
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0206 0.1512
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0147 0.0147
Loa Loa (eye worm) glutamate receptor 0.0096 0.0866 0.1271
Onchocerca volvulus 0.0018 0.0039 0.0041
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0065 0.0098
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0038 0.0344
Onchocerca volvulus 0.0018 0.0039 0.0041
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0015 0.0007 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0579 0.5303
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0555 0.0814
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.1151 1
Mycobacterium ulcerans arylsulfatase AtsD 0.0018 0.0039 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0275 0.2516
Loa Loa (eye worm) hypothetical protein 0.0028 0.0147 0.0215
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0077 0.0668 0.5472
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.027 0.0397
Brugia malayi hypothetical protein 0.002 0.0065 0.0098
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.006 0.0546
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0038 0.0344
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0147 0.0147
Brugia malayi nuclear receptor NHR-88 0.0028 0.0147 0.0221
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0123 0.1151 0.1151
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0054 0.0427 0.0991
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.001
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0147 0.034
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0229 0.0229
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0042 0.0005
Brugia malayi hypothetical protein 0.0038 0.0258 0.0388
Onchocerca volvulus 0.0018 0.0039 0.0041
Loa Loa (eye worm) hypothetical protein 0.0657 0.681 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0147 0.0221
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.0258 0.0388
Brugia malayi hypothetical protein 0.0478 0.4913 0.7395
Loa Loa (eye worm) hypothetical protein 0.0018 0.0039 0.0057
Trypanosoma cruzi WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative 0.0035 0.0223 0.204
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.0258 0.0258
Echinococcus granulosus neutral amino acid transporter 0.0123 0.1152 0.1152
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.006 0.0546
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0147 0.0147
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0042 0.0382
Schistosoma mansoni lamin 0.0081 0.0707 0.164
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0147 0.0215
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0042 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0042 0.0005
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0186 0.1871
Entamoeba histolytica hypothetical protein 0.0036 0.0229 0.2093
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0186 0.0197
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0186 0.2354
Loa Loa (eye worm) hypothetical protein 0.0038 0.0258 0.0378
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.1093 0.1399
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0555 0.0555
Leishmania major cathepsin L-like protease 0.0018 0.0042 0.0363
Schistosoma mansoni cpg binding protein 0.0031 0.0181 0.0421
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0258 0.0598
Schistosoma mansoni hypothetical protein 0.002 0.0065 0.0152
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0232 0.0258
Echinococcus multilocularis Excitatory amino acid transporter 0.0123 0.1152 0.1152
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0452 0.0452
Echinococcus granulosus beta-adrenergic receptor kinase 0.0038 0.0258 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0039 0.0001
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0039 0.0261 0.0383
Brugia malayi polk-prov protein 0.003 0.0172 0.0258
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0192 0.1098
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0147 0.034
Loa Loa (eye worm) hypothetical protein 0.0028 0.0147 0.0215
Echinococcus granulosus cathepsin l1 0.0018 0.0042 0.0042
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0115 0.1234
Trypanosoma cruzi WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative 0.0035 0.0223 0.204
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0123 0.1151 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0147 0.0215
Echinococcus granulosus sodium:dicarboxylate symporter 0.0123 0.1152 0.1152
Loa Loa (eye worm) cysteine protease 0.0018 0.0042 0.0061
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0065 0.0065
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0275 0.2516
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0042 0.0005
Echinococcus granulosus expressed protein 0.0748 0.778 0.778
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.055 0.1277
Schistosoma mansoni thyroid hormone receptor 0.0282 0.2843 0.6596
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0423 0.3875
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.027 0.2474
Schistosoma mansoni ap endonuclease 0.004 0.027 0.0627
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0275 0.2516
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0257 0.2577 0.3784
Brugia malayi Cache domain containing protein 0.0193 0.1894 0.2851

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) = 28.4 uM Cytotoxic activity against uninfected HEp-2 human lung epithelial carcinoma cell line ChEMBL. 14980651
CC50 (functional) = 28.4 uM Cytotoxic activity against uninfected HEp-2 human lung epithelial carcinoma cell line ChEMBL. 14980651
EC50 (functional) = 0.75 uM Antiviral activity against respiratory syncytial virus in HEp-2 human lung epithelial carcinoma cell line ChEMBL. 14980651
EC50 (functional) = 0.75 uM Antiviral activity against respiratory syncytial virus in HEp-2 human lung epithelial carcinoma cell line ChEMBL. 14980651
Therapeutic index (ADMET) = 38 Therapeutic index expressed as the ratio between CC50 and EC50 ChEMBL. 14980651

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 14980651

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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