Detailed information for compound 1435090

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 306.282 | Formula: C16H13F3N2O
  • H donors: 2 H acceptors: 1 LogP: 3.59 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1c(ccc2c1cccc2)C1=CC(=NCCN1)C(F)(F)F
  • InChi: 1S/C16H13F3N2O/c17-16(18,19)14-9-13(20-7-8-21-14)12-6-5-10-3-1-2-4-11(10)15(12)22/h1-6,9,20,22H,7-8H2
  • InChiKey: FJHBYTBPJRKNHU-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) No references
Homo sapiens v-rel avian reticuloendotheliosis viral oncogene homolog A No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0134 0.0813 0.0792
Echinococcus multilocularis muscleblind protein 0.018 0.1106 0.1771
Echinococcus granulosus nuclear factor of activated T cells 5 0.0374 0.2314 0.4426
Entamoeba histolytica hypothetical protein 0.0043 0.0249 0.1128
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0156 0.077
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0388 0.4631
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.2186 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0217 0.0195
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.2186 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0052 0.0236
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2186 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.003 0.0008
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0044 0.0022
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0476 0.0864
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.003 0.0008
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0134 0.0813 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0052 0.0029
Onchocerca volvulus Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog 0.0134 0.0813 1
Brugia malayi Death domain containing protein 0.0038 0.0216 0.1113
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0052 0.0236
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0008 0.003 0.0367
Plasmodium falciparum lipid/sterol:H+ symporter 0.0007 0.0022 0.0241
Onchocerca volvulus 0.0035 0.0194 0.2175
Echinococcus multilocularis protein dispatched 1 0.0058 0.0342 0.0513
Brugia malayi dimethylglycine dehydrogenase, mitochondrial precursor, putative 0.0134 0.0813 0.4538
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0296 0.0517
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.104 0.1664
Loa Loa (eye worm) hypothetical protein 0.0134 0.0813 0.0792
Chlamydia trachomatis D-amino acid dehydrogenase 0.0134 0.0813 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.003 0.0008
Mycobacterium ulcerans hypothetical protein 0.0029 0.0156 0.0127
Schistosoma mansoni ankyrin 23/unc44 0.0038 0.0216 0.0213
Schistosoma mansoni patched 1 0.0051 0.0296 0.0294
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0031 0.0002
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0026 0.0121
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2186 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0476 0.57
Brugia malayi hypothetical protein 0.0012 0.0052 0.0168
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.003 0.0367
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1764 0.336
Schistosoma mansoni ATP:guanidino kinase (Smc74) 0.0134 0.0813 0.081
Loa Loa (eye worm) hypothetical protein 0.0012 0.0052 0.0029
Entamoeba histolytica hypothetical protein 0.0043 0.0249 0.1128
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0156 0.0127
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0012 0.0052 0.0022
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0266 0.0457
Brugia malayi Uncoordinated protein 44 0.0038 0.0216 0.1113
Echinococcus granulosus muscleblind protein 0.018 0.1106 0.2085
Schistosoma mansoni netrin receptor unc5 0.0038 0.0216 0.0213
Onchocerca volvulus Dimethylglycine dehydrogenase, mitochondrial homolog 0.0134 0.0813 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0156 0.1616
Onchocerca volvulus 0.0008 0.003 0.0095
Echinococcus multilocularis FAD dependent oxidoreductase domain containing protein 0.0134 0.0813 0.1289
Onchocerca volvulus 0.0012 0.0052 0.037
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0476 0.2168
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0026 0.0121
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0721 0.4012
Echinococcus multilocularis protein patched 0.0051 0.0296 0.0439
Trichomonas vaginalis hypothetical protein 0.0004 0.0004 0.0016
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0476 0.5857
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0476 0.0473
Leishmania major glycerol-3-phosphate dehydrogenase-like protein 0.0134 0.0813 1
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0721 0.1339
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.6104 1
Onchocerca volvulus Putative fad oxidoreductase 0.0134 0.0813 1
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO 0.1602 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0438 0.0435
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.104 0.1958
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.0021 0.0111 0.0089
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.003 0.0008
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0296 0.0439
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0052 0.0635
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase GlpD2 0.0134 0.0813 0.0785
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0043 0.0122
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial 0.0134 0.0813 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0031 0.0003
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0342 0.1834
Brugia malayi pyruvate dehydrogenase phosphatase regulatory subunit precursor 0.0134 0.0813 0.4538
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0134 0.0813 0.3566
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0026 0.0121
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.2186 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0476 0.2605
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.0216 0.1113
Echinococcus granulosus microtubule associated protein 2 0.0833 0.5192 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0026 0.0121
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0156 0.0703
Mycobacterium leprae Probable cholesterol oxidase precursor ChoD (cholesterol-O2 oxidoreductase) 0.0134 0.0813 0.0785
Onchocerca volvulus 0.0029 0.0156 0.1696
Mycobacterium leprae Possible thiamine biosynthesis oxidoreductase ThiO 0.0134 0.0813 0.0785
Entamoeba histolytica hypothetical protein 0.0043 0.0249 0.1128
Echinococcus granulosus cpg binding protein 0.0037 0.0207 0.0342
Loa Loa (eye worm) hypothetical protein 0.0021 0.0111 0.0089
Echinococcus multilocularis netrin receptor unc 5 0.0038 0.0216 0.0307
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0156 0.0127
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0296 0.0517
Echinococcus granulosus dnaJ subfamily B 0.0494 0.3068 0.5886
Trichomonas vaginalis replication factor C large subunit, putative 0.0012 0.0052 0.0236
Toxoplasma gondii propionate-CoA ligase 0.0008 0.003 0.0095
Entamoeba histolytica hypothetical protein 0.0012 0.0052 0.0224
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0026 0.0121
Loa Loa (eye worm) hypothetical protein 0.0012 0.0052 0.0029
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0156 0.0127
Echinococcus multilocularis glycerol 3 phosphate dehydrogenase 0.0134 0.0813 0.1289
Echinococcus granulosus death domain containing protein 0.0038 0.0216 0.0361
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0134 0.0813 0.371
Loa Loa (eye worm) hypothetical protein 0.0038 0.0216 0.0194
Entamoeba histolytica hypothetical protein 0.0043 0.0249 0.1128
Brugia malayi hypothetical protein 0.0043 0.0249 0.1302
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0038 0.0216 0.0307
Schistosoma mansoni topbp1 0.0012 0.0052 0.0049
Trichomonas vaginalis helicase, putative 0.0008 0.0026 0.0121
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0156 0.1616
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0296 0.1356
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.003 0.0367
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1764 0.2855
Mycobacterium ulcerans D-amino acid oxidase Aao 0.1602 1 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0194 0.0172
Onchocerca volvulus 0.0008 0.003 0.0095
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0156 0.077
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.003 0.0043
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.3068 0.5001
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0026 0.0121
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.2186 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.003 0.0136
Schistosoma mansoni hypothetical protein 0.0049 0.0285 0.0282
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.0052 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0026 0.0121
Loa Loa (eye worm) hypothetical protein 0.0051 0.0296 0.0275
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0156 0.0146
Brugia malayi hypothetical protein 0.0012 0.0052 0.0168
Brugia malayi AMP-binding enzyme family protein 0.0008 0.003 0.0043
Plasmodium vivax acetyl-CoA synthetase, putative 0.0008 0.003 0.0095
Loa Loa (eye worm) hypothetical protein 0.0012 0.0052 0.0029
Onchocerca volvulus 0.0008 0.003 0.0095
Schistosoma mansoni hypothetical protein 0.0043 0.0249 0.0246
Echinococcus granulosus FAD dependent oxidoreductase domain containing protein 0.0134 0.0813 0.1517
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0156 0.0127
Echinococcus granulosus glycerol 3 phosphate dehydrogenase 0.0134 0.0813 0.1517
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.003 0.0367
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.1056 0.1029
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0249 0.0361
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0026 0.0121
Brugia malayi AMP-binding enzyme family protein 0.0008 0.003 0.0043
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0111 0.0097
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0012 0.0052 0.037
Loa Loa (eye worm) hypothetical protein 0.0021 0.0111 0.0089
Loa Loa (eye worm) hypothetical protein 0.0021 0.0111 0.0089
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0156 0.0703
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0104 0.0089
Schistosoma mansoni cpg binding protein 0.0035 0.0194 0.0191
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.0052 0.0049
Brugia malayi topoisomerase 0.0012 0.0052 0.0168
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0052 0.0236
Schistosoma mansoni fad oxidoreductase 0.0134 0.0813 0.081
Trypanosoma cruzi FAD dependent oxidoreductase, putative 0.0134 0.0813 1
Onchocerca volvulus 0.0058 0.0342 0.4041
Schistosoma mansoni d-amino acid oxidase 0.1602 1 1
Brugia malayi Muscleblind-like protein 0.018 0.1106 0.6222
Loa Loa (eye worm) hypothetical protein 0.0012 0.0052 0.0029
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.003 0.0095
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.003 0.0008
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.003 0.0008
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0156 0.0127
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.003 0.0008
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0111 0.1123
Trichomonas vaginalis conserved hypothetical protein 0.0004 0.0004 0.0016
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0104 0.0089
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2186 1
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0052 0.0635
Toxoplasma gondii hypothetical protein 0.0134 0.0813 1
Echinococcus granulosus replication factor c subunit 1 0.0012 0.0052 0.0042
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2186 1
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0266 0.0389
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0026 0.0121
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0111 0.1337
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.003 0.0008
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0026 0.0121
Onchocerca volvulus Netrin receptor homolog 0.0038 0.0216 0.2453
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0052 0.0236
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0038 0.0217 0.0214
Trypanosoma brucei FAD dependent oxidoreductase, putative 0.0134 0.0813 1
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 20 0.0134 0.0813 1
Schistosoma mansoni topbp1 0.0012 0.0052 0.0049
Trypanosoma brucei electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0134 0.0813 1
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0012 0.0052 0.0022
Loa Loa (eye worm) hypothetical protein 0.0134 0.0813 0.0792
Schistosoma mansoni hypothetical protein 0.0058 0.0342 0.0339
Echinococcus multilocularis muscleblind protein 1 0.018 0.1106 0.1771
Brugia malayi AMP-binding enzyme family protein 0.0008 0.003 0.0043
Schistosoma mansoni hypothetical protein 0.0038 0.0216 0.0213
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0156 0.0127
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0044 0.0024
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0134 0.0813 1
Schistosoma mansoni NAD dehydrogenase 0.0134 0.0813 0.081
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0111 0.0781
Brugia malayi CXXC zinc finger family protein 0.0035 0.0194 0.0987
Echinococcus multilocularis expressed conserved protein 0.0112 0.0676 0.1064
Schistosoma mansoni hypothetical protein 0.0049 0.0285 0.0282
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.1056 0.1029
Schistosoma mansoni cpg binding protein 0.0037 0.0207 0.0204
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.003 0.0043
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.003 0.0008
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0038 0.0216 0.0194
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0111 0.0082
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0052 0.0236
Loa Loa (eye worm) hypothetical protein 0.0021 0.0111 0.0089
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0296 0.0275
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0031 0.0002
Schistosoma mansoni fad oxidoreductase 0.0134 0.0813 0.081
Loa Loa (eye worm) hypothetical protein 0.0286 0.1764 0.1746
Echinococcus multilocularis Ankyrin 0.0038 0.0217 0.0308
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0026 0.0121
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.003 0.0008
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.003 0.0136
Brugia malayi Pax transcription activation domain interacting protein 0.0012 0.0052 0.0168
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0038 0.0216 0.0361
Mycobacterium tuberculosis Possible thiamine biosynthesis oxidoreductase ThiO 0.0134 0.0813 0.0864
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.003 0.0008
Onchocerca volvulus 0.0008 0.003 0.0095
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0249 0.0425
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0031 0.0028
Loa Loa (eye worm) hypothetical protein 0.0029 0.0156 0.0134
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0374 0.2314 0.3761
Loa Loa (eye worm) hypothetical protein 0.018 0.1106 0.1086
Loa Loa (eye worm) hypothetical protein 0.0029 0.0156 0.0134
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0104 0.0089
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0026 0.0121
Loa Loa (eye worm) hypothetical protein 0.018 0.1106 0.1086
Schistosoma mansoni hypothetical protein 0.0049 0.0285 0.0282
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0012 0.0052 0.5
Leishmania major hypothetical protein, conserved 0.0134 0.0813 1
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0052 0.0635
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase 0.0134 0.0813 0.0785
Mycobacterium ulcerans thiamine biosynthesis oxidoreductase ThiO 0.0134 0.0813 0.0785
Plasmodium falciparum FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0134 0.0813 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0052 0.0236
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2186 1
Brugia malayi AMP-binding enzyme family protein 0.0008 0.003 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0052 0.0236
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0044 0.0028
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0134 0.0813 1
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0008 0.003 0.0333
Loa Loa (eye worm) hypothetical protein 0.0062 0.0368 0.0347
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0052 0.0236
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0156 0.1616
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0476 0.0455
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0026 0.0121
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0476 0.5857
Loa Loa (eye worm) glycerol-3-phosphate dehydrogenase 0.0134 0.0813 0.0792
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.003 0.0367
Brugia malayi cDNA sequence BC016226 0.0134 0.0813 0.4538
Toxoplasma gondii FAD-dependent glycerol-3-phosphate dehydrogenase 0.0134 0.0813 1
Schistosoma mansoni survival motor neuron protein 0.0058 0.0342 0.0339
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0008 0.003 0.0367
Echinococcus granulosus netrin receptor unc 5 0.0038 0.0216 0.0361
Trypanosoma cruzi FHA domain containing protein, putative 0.0012 0.0052 0.0635
Schistosoma mansoni hypothetical protein 0.0494 0.3068 0.3066
Echinococcus multilocularis nibrin 0.0012 0.0052 0.0036
Leishmania major hypothetical protein, conserved 0.0134 0.0813 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0026 0.0121
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.5192 0.8497
Plasmodium vivax FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0134 0.0813 1
Echinococcus granulosus expressed conserved protein 0.0112 0.0676 0.1252
Brugia malayi Protein kinase domain containing protein 0.0038 0.0216 0.1113
Loa Loa (eye worm) hypothetical protein 0.0119 0.0721 0.07
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.003 0.0008
Plasmodium vivax replication factor C subunit 1, putative 0.0012 0.0052 0.037
Trypanosoma brucei L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0134 0.0813 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2186 1
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao 0.1468 0.9165 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2186 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0026 0.0121
Plasmodium falciparum replication factor C subunit 1, putative 0.0012 0.0052 0.0602
Echinococcus granulosus nibrin 0.0012 0.0052 0.0042
Schistosoma mansoni DNA ligase IV 0.0012 0.0052 0.0049
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0721 0.3291
Loa Loa (eye worm) oxidoreductase 0.0008 0.003 0.0008
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.003 0.0027
Entamoeba histolytica anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative 0.0134 0.0813 0.371
Schistosoma mansoni hypothetical protein 0.0049 0.0285 0.0282
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0156 0.0127
Brugia malayi DKFZp564C0469 protein 0.0012 0.0052 0.0168
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0249 0.0246
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0026 0.0121
Brugia malayi CHE-14 protein 0.0051 0.0296 0.1574
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0052 0.0236
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0156 0.0146
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.0052 0.037
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.1056 0.1131
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0134 0.0813 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0004 0.0004 0.0016
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0156 0.0127
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0031 0.0003
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0156 0.0127
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.003 0.0095
Echinococcus granulosus Ankyrin 0.0038 0.0217 0.0363
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0134 0.0813 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.003 0.0008
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0052 0.0635
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0476 0.0735
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0104 0.0089
Brugia malayi hypothetical protein 0.0286 0.1764 1
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0134 0.0813 0.0785
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0012 0.0052 0.0168
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0008 0.003 0.0124
Schistosoma mansoni cpg binding protein 0.0037 0.0207 0.0204
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.2186 1
Schistosoma mansoni glycerol-3-phosphate dehydrogenase 0.0134 0.0813 0.081
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0733 0.073
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.003 0.0008
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase, putative 0.0134 0.0813 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0156 0.0134
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.5192 0.519
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.003 0.0008
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0156 0.077
Echinococcus multilocularis cpg binding protein 0.0037 0.0207 0.0291
Loa Loa (eye worm) hypothetical protein 0.0012 0.0052 0.0029
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0156 0.0703
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0721 0.1138
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0476 0.5857
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0012 0.0052 0.0224
Brugia malayi RE18450p 0.0134 0.0813 0.4538
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0026 0.0121

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) < 0.1 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Activators of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells. (Class of assay: confirmatory) [Related pubchem assays: 1829 (Project Summary), 1814 (Primary HTS)] ChEMBL. No reference
EC50 (functional) = 17.709 um PUBCHEM_BIOASSAY: Name: High Throughput Screen to Identify Compounds that increase expression of NF-kB in Human Neuronal Cells - Dose Response. (Class of assay: confirmatory) [Related pubchem assays: 1239 ] ChEMBL. No reference
Potency (functional) 0.5623 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.3115 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 1.4092 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.9093 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 4.7755 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (binding) = 6.3096 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) 7.0795 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 9.1962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 16.3535 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 32.6427 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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