Detailed information for compound 1435287

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 385.422 | Formula: C23H22F3NO
  • H donors: 0 H acceptors: 1 LogP: 5.03 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: FC(c1ccc(cc1)C1N(Cc2ccccc2)C(=O)C2(C1C=CCC2)C)(F)F
  • InChi: 1S/C23H22F3NO/c1-22-14-6-5-9-19(22)20(17-10-12-18(13-11-17)23(24,25)26)27(21(22)28)15-16-7-3-2-4-8-16/h2-5,7-13,19-20H,6,14-15H2,1H3
  • InChiKey: CQQQZCZQSNWEPY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ap endonuclease 0.0023 0.0025 0.0017
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0256 0.1101 0.1094
Loa Loa (eye worm) phosphatidylinositol 3 0.0155 0.0634 0.0928
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0256 0.1101 0.2312
Loa Loa (eye worm) hypothetical protein 0.0155 0.0634 0.0928
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0155 0.0634 0.1308
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0256 0.1101 0.1621
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0893 0.4033 0.8894
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.012 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0762 0.343 0.7313
Loa Loa (eye worm) hypothetical protein 0.0038 0.0097 0.0132
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0273 0.0265
Loa Loa (eye worm) hypothetical protein 0.0322 0.1403 0.2068
Trichomonas vaginalis PIKK family atypical protein kinase 0.081 0.3655 0.7796
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0155 0.0634 0.1716
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1649 0.752 0.7518
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0273 0.0393
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2188 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0008 0.0000061935
Onchocerca volvulus 0.0038 0.0097 0.0092
Entamoeba histolytica hypothetical protein 0.0155 0.0634 0.1308
Echinococcus multilocularis GPCR, family 2 0.0019 0.0008 0.0000061935
Schistosoma mansoni hypothetical protein 0.0019 0.0008 0.0000061935
Brugia malayi Cytochrome P450 family protein 0.0028 0.0051 0.0051
Plasmodium vivax SET domain protein, putative 0.0036 0.0086 0.0571
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0273 0.0265
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0827 0.3732 0.8229
Schistosoma mansoni hypothetical protein 0.0283 0.1225 0.1219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0893 0.4033 0.8608
Schistosoma mansoni hypothetical protein 0.0019 0.0008 0.0000061935
Leishmania major phosphatidylinositol kinase, putative 0.0155 0.0634 0.1383
Loa Loa (eye worm) hypothetical protein 0.0148 0.0602 0.0881
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0396 0.1746 0.174
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0241 0.1033 0.1026
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0256 0.1101 0.2312
Trichomonas vaginalis PIKK family atypical protein kinase 0.068 0.3051 0.65
Brugia malayi beta-lactamase 0.0038 0.0097 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0283 0.1225 0.2579
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1357 0.2861
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2188 1 1
Echinococcus multilocularis Zinc finger, PHD finger 0.0256 0.1101 0.1094
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0273 0.0265
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0778 0.3505 0.7474
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0616 0.2759 0.2759
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0157 0.041
Loa Loa (eye worm) acetyltransferase 0.0175 0.0727 0.1066
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.1357 0.1357
Trichomonas vaginalis PIKK family atypical protein kinase 0.0827 0.3731 0.7959
Trichomonas vaginalis PIKK family atypical protein kinase 0.0609 0.2728 0.5805
Loa Loa (eye worm) hypothetical protein 0.0218 0.0925 0.1359
Echinococcus granulosus neuropeptide receptor A26 0.0568 0.2536 0.253
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0893 0.4033 0.4028
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0914 0.1909
Brugia malayi TAR-binding protein 0.0076 0.0273 0.0273
Giardia lamblia Phosphatidylinositol 4-kinase 0.0155 0.0634 0.1519
Brugia malayi FAT domain containing protein 0.0283 0.1225 0.1225
Echinococcus multilocularis serine protein kinase ATM 0.0396 0.1746 0.174
Plasmodium vivax hypothetical protein 0.0155 0.0634 0.5656
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0273 0.0265
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0155 0.0634 0.1308
Echinococcus multilocularis geminin 0.0175 0.0728 0.0721
Loa Loa (eye worm) hypothetical protein 0.0041 0.011 0.0151
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0268 0.1155 0.1148
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0584 0.0855
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0097 0.0089
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1001 0.4534 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0097 0.0097
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0396 0.1746 0.1746
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0051 0.0064
Schistosoma mansoni hypothetical protein 0.0043 0.012 0.0113
Echinococcus granulosus tar DNA binding protein 0.0076 0.0273 0.0265
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0000091757
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0155 0.0634 0.0626
Entamoeba histolytica hypothetical protein 0.0043 0.012 0.0205
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2188 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0155 0.0634 0.0928
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0155 0.0634 0.0626
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0893 0.4033 0.8608
Trichomonas vaginalis PIKK family atypical protein kinase 0.081 0.3655 0.7796
Brugia malayi beta-lactamase family protein 0.0038 0.0097 0.0097
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0321 0.1401 0.3433
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0025 0.0037
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0086 0.0078
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1357 0.2861
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1033 0.4681 0.4681
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.3354 0.7149
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0256 0.1101 0.2998
Trichomonas vaginalis PIKK family atypical protein kinase 0.0893 0.4033 0.8608
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0283 0.1225 0.1219
Onchocerca volvulus Huntingtin homolog 0.0148 0.0602 0.4476
Trichomonas vaginalis PIKK family atypical protein kinase 0.081 0.3655 0.7796
Entamoeba histolytica protein kinase rad3, putative 0.0396 0.1746 0.3697
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0155 0.0634 0.5656
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0008 0.0000091757
Trichomonas vaginalis PIKK family atypical protein kinase 0.081 0.3655 0.7796
Brugia malayi RNA binding protein 0.0076 0.0273 0.0273
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0893 0.4033 0.8894
Loa Loa (eye worm) phosphatidylinositol 3 0.0155 0.0634 0.0928
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0273 0.0265
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0863 0.18
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0893 0.4033 0.8894
Loa Loa (eye worm) hypothetical protein 0.0283 0.1225 0.1805
Brugia malayi beta-lactamase family protein 0.0038 0.0097 0.0097
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0256 0.1101 0.2312
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.0727 0.0719
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.012 0.0113
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0044 0.008
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0893 0.4033 0.4033
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0256 0.1101 0.2312
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0097 0.0855
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0396 0.1746 0.174
Onchocerca volvulus Huntingtin homolog 0.0148 0.0602 0.4476
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0704 0.0697
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0155 0.0634 0.1383
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0396 0.1746 0.1746
Loa Loa (eye worm) phosphatidylinositol 3 0.0155 0.0634 0.0928
Leishmania major hypothetical protein, unknown function 0.0155 0.0634 0.1383
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0025 0.5
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0025 0.0037
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0155 0.0634 0.0626
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1033 0.4681 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.0051 0.4881
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.3352 0.7146
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0198 0.0198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.3354 0.7149
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0097 0.0197
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.0727 0.0719
Trichomonas vaginalis PIKK family atypical protein kinase 0.0527 0.2349 0.4992
Schistosoma mansoni fkbp-rapamycin associated protein 0.0396 0.1746 0.174
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0245 0.1049 1
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0863 0.18
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.068 0.3051 0.6725
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0097 0.1422
Loa Loa (eye worm) hypothetical protein 0.0036 0.0086 0.0116
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0155 0.0634 0.0626
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.1033 0.4681 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0086 0.0078
Loa Loa (eye worm) hypothetical protein 0.0027 0.0044 0.0053
Echinococcus granulosus geminin 0.0175 0.0728 0.0721
Trichomonas vaginalis PIKK family atypical protein kinase 0.0527 0.2349 0.4992
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0044 0.0177
Giardia lamblia GTOR 0.0893 0.4033 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0893 0.4033 0.8608
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0155 0.0634 0.1308
Giardia lamblia Hypothetical protein 0.0155 0.0634 0.1519
Brugia malayi Pre-SET motif family protein 0.0036 0.0086 0.0086
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0678 0.3045 0.3039
Loa Loa (eye worm) hypothetical protein 0.0396 0.1746 0.2577
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0155 0.0634 0.0634
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0396 0.1746 0.3841
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0044 0.0099
Entamoeba histolytica hypothetical protein 0.0155 0.0634 0.1308
Echinococcus multilocularis neuropeptide s receptor 0.0568 0.2536 0.253
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0893 0.4033 0.4028
Onchocerca volvulus 0.0038 0.0097 0.0092
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0423 0.1868 0.3959
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0097 0.0155
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0283 0.1225 0.1219
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0097 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0586 0.2618 0.557
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0778 0.3505 0.7474
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0097 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0827 0.3731 0.7959
Loa Loa (eye worm) hypothetical protein 0.0038 0.0097 0.0132
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.0925 0.7278
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0863 0.18
Mycobacterium leprae conserved hypothetical protein 0.0155 0.0634 1
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0863 0.18
Schistosoma mansoni hypothetical protein 0.0041 0.011 0.0102
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0893 0.4033 0.4028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0827 0.3731 0.7959
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.008 0.0072
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0025 0.0163
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0155 0.0634 0.0626
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0396 0.1746 0.174
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0025 0.1904
Trichomonas vaginalis PIKK family atypical protein kinase 0.068 0.3051 0.65
Leishmania major cytochrome p450-like protein 0.0028 0.0051 0.0096
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0008 0.0000061935
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0504 0.2241 0.4934
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0097 0.0855
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0256 0.1101 0.2312
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0097 0.0132
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0155 0.0634 0.0626
Plasmodium vivax hypothetical protein, conserved 0.0155 0.0634 0.5656
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0256 0.1101 0.1094
Loa Loa (eye worm) hypothetical protein 0.0065 0.0221 0.0316
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0155 0.0634 0.0626
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0138 0.0242
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0097 0.0669
Brugia malayi Cytochrome P450 family protein 0.0028 0.0051 0.0051
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0138 0.1048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.3354 0.7149
Entamoeba histolytica hypothetical protein 0.0867 0.3914 0.8353
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0008 0.0000061935
Loa Loa (eye worm) cytochrome P450 family protein 0.006 0.0197 0.028
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0155 0.0634 0.1716
Loa Loa (eye worm) hypothetical protein 0.0038 0.0097 0.0132
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0155 0.0634 0.0626
Trichomonas vaginalis PIKK family atypical protein kinase 0.0718 0.3229 0.688
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0423 0.1868 0.3959
Trichomonas vaginalis conserved hypothetical protein 0.0438 0.1939 0.4111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.0634 0.1308
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0157 0.1231
Entamoeba histolytica hypothetical protein 0.0396 0.1746 0.3697
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0097 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0044 0.0036
Loa Loa (eye worm) hypothetical protein 0.006 0.0198 0.0281
Trichomonas vaginalis PIKK family atypical protein kinase 0.068 0.3051 0.65
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0157 0.015
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0086 0.0078
Trypanosoma brucei cytochrome P450, putative 0.0028 0.0051 0.0096
Entamoeba histolytica hypothetical protein 0.0043 0.012 0.0205
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1357 0.2861
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0025 0.0017
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0008 0.0008
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1238 0.2606
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1649 0.752 0.7518
Trichomonas vaginalis PIKK family atypical protein kinase 0.081 0.3655 0.7796
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0286 0.1237 0.2715
Schistosoma mansoni hypothetical protein 0.0019 0.0008 0.0000061935
Loa Loa (eye worm) phosphatidylinositol 3 0.1001 0.4534 0.6711
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0155 0.0634 0.5656
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0086 0.0078
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.0863 0.6743
Loa Loa (eye worm) phosphatidylinositol 3 0.0268 0.1155 0.1701
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0256 0.1101 0.1094
Brugia malayi Cytochrome P450 family protein 0.0019 0.0008 0.0008
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0256 0.1101 1
Toxoplasma gondii FATC domain-containing protein 0.0396 0.1746 0.4767
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0256 0.1101 0.2416
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0097 0.0089
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0008 0.0000061935
Leishmania major phosphatidylinositol 3-kinase, putative 0.068 0.3051 0.6725
Mycobacterium ulcerans lipase LipD 0.0038 0.0097 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0893 0.4033 0.4028
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0839 0.3788 0.3783
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0423 0.1868 0.3959
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0097 0.0155
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0097 0.0855
Trichomonas vaginalis PIKK family atypical protein kinase 0.0527 0.2349 0.4992
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0893 0.4033 0.4028
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0256 0.1101 0.1094
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0051 0.0043
Onchocerca volvulus 0.0155 0.0634 0.4752
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0914 0.1909
Loa Loa (eye worm) hypothetical protein 0.0322 0.1403 0.2068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0396 0.1746 0.3697
Leishmania major phosphatidylinositol 4-kinase, putative 0.0155 0.0634 0.1383
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0273 0.0265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0155 0.0634 0.1308
Schistosoma mansoni hypothetical protein 0.0155 0.0634 0.0626
Echinococcus granulosus neuropeptide s receptor 0.0568 0.2536 0.253
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0423 0.1868 0.1868
Trichomonas vaginalis PIKK family atypical protein kinase 0.0827 0.3731 0.7959
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0097 0.0155
Mycobacterium ulcerans hypothetical protein 0.0038 0.0097 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0893 0.4033 0.5968
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0155 0.0634 0.5656
Onchocerca volvulus 0.0155 0.0634 0.4752
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.1033 0.4681 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.1357 0.2001
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0155 0.0634 0.1383
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0867 0.3914 0.8353
Trichomonas vaginalis conserved hypothetical protein 0.0241 0.1033 0.2164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0827 0.3731 0.7959
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0155 0.0634 0.0626
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0423 0.1868 0.3959
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0396 0.1746 0.174
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0155 0.0634 0.0626
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0878 0.3968 0.8468
Brugia malayi hypothetical protein 0.0027 0.0044 0.0044
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0512 0.2278 0.4838
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0438 0.1939 0.5295
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0256 0.1101 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0025 0.0025
Onchocerca volvulus 0.0038 0.0097 0.0092
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.012 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0396 0.1746 0.3697
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0051 0.0064
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0155 0.0634 0.5656
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0155 0.0634 0.5656
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0273 0.0273
Echinococcus multilocularis 0.0155 0.0634 0.0626
Echinococcus granulosus serine protein kinase ATM 0.0396 0.1746 0.174
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0256 0.1101 0.1094
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0273 0.0393
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0086 0.0078
Leishmania major hypothetical protein, conserved 0.0027 0.0044 0.008
Loa Loa (eye worm) hypothetical protein 0.0038 0.0097 0.0132
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0718 0.3229 0.688
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0155 0.0634 0.0626
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0008 0.0008
Toxoplasma gondii target of rapamycin (TOR), putative 0.081 0.3655 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0762 0.343 0.7313
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0155 0.0634 0.0626
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0678 0.3045 0.3039
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2188 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0051 0.0064
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0155 0.0634 0.0626
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0678 0.3045 0.3045
Trichomonas vaginalis PIKK family atypical protein kinase 0.081 0.3655 0.7796
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0863 0.18
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0097 0.0155
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0612 0.2738 0.6768
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0157 0.041
Brugia malayi N-terminal motif family protein 0.0218 0.0925 0.0925
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0044 0.0036
Loa Loa (eye worm) hypothetical protein 0.0438 0.1939 0.2863
Entamoeba histolytica hypothetical protein 0.0043 0.012 0.0205
Toxoplasma gondii exonuclease III APE 0.0023 0.0025 0.0046
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0893 0.4033 0.8894
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0256 0.1101 0.2416
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0051 0.0043
Trypanosoma cruzi target of rapamycin kinase 3 0.0827 0.3732 0.3727
Loa Loa (eye worm) hypothetical protein 0.0038 0.0097 0.0132
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0097 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1033 0.4681 0.4677
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1078 0.1587
Onchocerca volvulus 0.0286 0.1238 1
Mycobacterium tuberculosis Conserved protein 0.0038 0.0097 0.0855
Trichomonas vaginalis PIKK family atypical protein kinase 0.0544 0.2426 0.5156
Trichomonas vaginalis PIKK family atypical protein kinase 0.081 0.3655 0.7796
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1357 0.2861
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0423 0.1868 0.1862
Trichomonas vaginalis PIKK family atypical protein kinase 0.022 0.0935 0.1954
Loa Loa (eye worm) beta-lactamase 0.0038 0.0097 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.068 0.3051 0.65
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0097 0.0855
Mycobacterium leprae Probable lipase LipE 0.0038 0.0097 0.1422
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0155 0.0634 0.1716
Leishmania major hypothetical protein, conserved 0.0155 0.0634 0.1383
Schistosoma mansoni ap endonuclease 0.0023 0.0025 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.1001 0.4534 0.9684
Mycobacterium tuberculosis Conserved protein 0.0038 0.0097 0.0855
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0086 0.0078
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.0634 0.6011
Loa Loa (eye worm) phosphatidylinositol 3 0.1483 0.6752 1
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0097 0.0089
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0097 0.0155
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0044 0.0177
Loa Loa (eye worm) hypothetical protein 0.0241 0.1033 0.1519
Loa Loa (eye worm) hypothetical protein 0.0148 0.0602 0.0881
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0256 0.1101 0.2998
Loa Loa (eye worm) hypothetical protein 0.0355 0.1557 0.2296
Loa Loa (eye worm) hypothetical protein 0.0038 0.0097 0.0132
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0396 0.1746 0.174
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.1033 0.4681 0.4677
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0157 0.0285
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0025 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0893 0.4033 0.8608
Entamoeba histolytica hypothetical protein 0.0155 0.0634 0.1308
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0086 0.0215
Leishmania major phosphatidylinositol kinase related protein, putative 0.0155 0.0634 0.1383
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1001 0.4534 1
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0863 0.18
Toxoplasma gondii ABC1 family protein 0.0038 0.0097 0.0244
Brugia malayi MH2 domain containing protein 0.0144 0.0584 0.0584
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0584 0.0855
Echinococcus multilocularis neuropeptide receptor A26 0.0568 0.2536 0.253
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0025 0.0017
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0025 0.0017
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0138 0.0281
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0155 0.0634 0.0634
Schistosoma mansoni hypothetical protein 0.0175 0.0728 0.0721
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0155 0.0634 0.0626
Mycobacterium tuberculosis Conserved protein 0.0038 0.0097 0.0855
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0423 0.1868 0.3959
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0256 0.1101 0.1094
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0198 0.0281
Loa Loa (eye worm) phosphatidylinositol kinase 0.0155 0.0634 0.0928
Mycobacterium ulcerans beta-lactamase 0.0038 0.0097 1
Leishmania major hypothetical protein, conserved 0.0038 0.0097 0.0197
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0863 0.18
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.3352 0.7146
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0097 0.0855
Schistosoma mansoni hypothetical protein 0.0175 0.0728 0.0721
Loa Loa (eye worm) hypothetical protein 0.0678 0.3045 0.4503
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.0727 0.0727
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0025 0.5
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1649 0.752 0.7518
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0157 0.0285
Leishmania major phosphatidylinositol 3-kinase, putative 0.0256 0.1101 0.2416
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0423 0.1868 0.1862
Schistosoma mansoni hypothetical protein 0.0019 0.0008 0.0000061935
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0198 0.0198
Trichomonas vaginalis esterase, putative 0.0038 0.0097 0.0155
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0086 0.0078
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0827 0.3732 0.8229
Trichomonas vaginalis PIKK family atypical protein kinase 0.0241 0.1033 0.2164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.3352 0.7146
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0256 0.1101 0.1094
Brugia malayi hypothetical protein 0.0148 0.0602 0.0602
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0025 0.0025
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1357 0.2861
Brugia malayi Cytochrome P450 family protein 0.006 0.0197 0.0197
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2188 1 1
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0256 0.1101 0.1101
Loa Loa (eye worm) RNA binding protein 0.0076 0.0273 0.0393
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0097 0.0855
Brugia malayi cytochrome P450 0.0019 0.0008 0.0008
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0423 0.1868 0.4111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0745 0.3354 0.7149
Brugia malayi hypothetical protein 0.0043 0.012 0.012
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0155 0.0634 0.0626
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.1033 0.4681 1
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1357 0.2861
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0097 0.0855
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.011 0.011
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0044 0.0177
Entamoeba histolytica hypothetical protein 0.0043 0.012 0.0205
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0155 0.0634 0.0634
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0097 0.0089
Brugia malayi Pre-SET motif family protein 0.0251 0.1078 0.1078
Echinococcus granulosus GPCR family 2 0.0019 0.0008 0.0000061935

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.