Detailed information for compound 1441902

Basic information

Technical information
  • TDR Targets ID: 1441902
  • Name: N-(5H-chromeno[4,3-d]pyrimidin-2-yl)-3-nitrob enzamide
  • MW: 348.312 | Formula: C18H12N4O4
  • H donors: 1 H acceptors: 5 LogP: 2.41 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cccc(c1)[N+](=O)[O-])Nc1ncc2c(n1)c1ccccc1OC2
  • InChi: 1S/C18H12N4O4/c23-17(11-4-3-5-13(8-11)22(24)25)21-18-19-9-12-10-26-15-7-2-1-6-14(15)16(12)20-18/h1-9H,10H2,(H,19,20,21,23)
  • InChiKey: UQVRJKYFBSLIDZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(5H-chromeno[4,3-d]pyrimidin-2-yl)-3-nitro-benzamide
  • MLS000720751
  • N-(5H-chromeno[4,3-d]pyrimidin-2-yl)-3-nitrobenzenecarboxamide
  • SMR000336752
  • 5X-0934

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens fatty acid synthase Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Toxoplasma gondii type I fatty acid synthase, putative Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks8 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae Polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Neospora caninum KR domain domain-containing protein, putative Get druggable targets OG5_126633 All targets in OG5_126633
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas Get druggable targets OG5_126633 All targets in OG5_126633
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii AMP-binding enzyme domain-containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB Get druggable targets OG5_126633 All targets in OG5_126633
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks9 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks1 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Polyketide synthase Pks2 Get druggable targets OG5_126633 All targets in OG5_126633
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Get druggable targets OG5_126633 All targets in OG5_126633
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD Get druggable targets OG5_126633 All targets in OG5_126633
Onchocerca volvulus Fatty acid synthase homolog Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium parvum type I fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Neospora caninum Soraphen polyketide synthase A, related Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA Get druggable targets OG5_126633 All targets in OG5_126633
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA Get druggable targets OG5_126633 All targets in OG5_126633
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks5 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium parvum polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) acyl carrier protein Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB Get druggable targets OG5_126633 All targets in OG5_126633
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii type I fatty acid synthase, putative Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks15 Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium ulcerans polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Polyketide synthase Pks12 Get druggable targets OG5_126633 All targets in OG5_126633
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis Probable polyketide synthase Pks7 Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas Get druggable targets OG5_126633 All targets in OG5_126633
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Pks9 Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii type I fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae Probable polyketide synthase Pks1 Get druggable targets OG5_126633 All targets in OG5_126633
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni multidrug resistance protein 0.0011 0.0007 0.0064
Loa Loa (eye worm) ShTK domain-containing protein 0.0179 0.091 0.909
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0081 0.0382 0.2625
Leishmania major telomerase reverse transcriptase, putative 0.0511 0.2695 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.003 0.0111 0.0387
Echinococcus multilocularis sterol regulatory element binding protein 0.0084 0.0401 0.0955
Echinococcus granulosus tar DNA binding protein 0.0126 0.0624 0.4289
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.009 0.0888
Schistosoma mansoni tubulin subunit alpha 0.0017 0.0042 0.0407
Echinococcus multilocularis Tubulin alpha 1 chain 0.0017 0.0042 0.0099
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0073 0.01
Loa Loa (eye worm) patched family protein 0.0012 0.0013 0.0123
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0123
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0041 0.017 0.0629
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0011 0.0007 0.0162
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.048 0.0661
Loa Loa (eye worm) multidrug resistance protein 3 0.0011 0.0007 0.0065
Brugia malayi SWIRM domain containing protein 0.0041 0.017 0.0233
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0011 0.0007 0.0162
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0313 0.163 1
Brugia malayi Patched family protein 0.0012 0.0013 0.0017
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0624 0.6125
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0187 0.0444
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.003 0.0111 0.0387
Brugia malayi Muscleblind-like protein 0.018 0.0918 0.1265
Loa Loa (eye worm) hypothetical protein 0.0017 0.0042 0.0411
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0123
Giardia lamblia Telomerase catalytic subunit 0.0511 0.2695 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0065
Brugia malayi Patched related family protein 10 0.0012 0.0013 0.0017
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0084 0.0401 0.3998
Brugia malayi TAR-binding protein 0.0126 0.0624 0.0859
Schistosoma mansoni tyrosine kinase 0.0081 0.0382 0.3748
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.002 0.0054 0.0198
Plasmodium vivax hypothetical protein, conserved 0.0041 0.017 0.0629
Loa Loa (eye worm) hypothetical protein 0.0179 0.091 0.909
Onchocerca volvulus Protein patched homolog 0.0012 0.0013 0.0012
Echinococcus multilocularis GPCR, family 2 0.0031 0.0117 0.0278
Trichomonas vaginalis ABC transporter, putative 0.0011 0.0007 0.0162
Onchocerca volvulus 0.0059 0.0267 0.0266
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0024 0.0079 0.0257
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0073 0.3844
Echinococcus multilocularis Niemann Pick C1 protein 0.028 0.1453 0.3466
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0011 0.0007 0.0065
Brugia malayi Furin-like cysteine rich region family protein 0.015 0.0754 0.1039
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0041 0.017 0.0404
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0052
Schistosoma mansoni hypothetical protein 0.0035 0.0137 0.1344
Plasmodium vivax multidrug resistance protein 1, putative 0.0011 0.0007 0.0024
Loa Loa (eye worm) tubulin alpha chain 0.0017 0.0042 0.0414
Loa Loa (eye worm) hypothetical protein 0.0041 0.017 0.1693
Schistosoma mansoni tyrosine kinase 0.008 0.0377 0.3703
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0042 0.0253
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0001 0.0000014531
Schistosoma mansoni tyrosine kinase 0.015 0.0754 0.7412
Plasmodium vivax telomerase reverse transcriptase, putative 0.0511 0.2695 1
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.001 0.0002 0.0007
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0011 0.0007 0.0162
Brugia malayi Patched family protein 0.0012 0.0013 0.0017
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0065
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0073 0.0725
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0041 0.017 0.0551
Leishmania major alpha tubulin 0.0017 0.0042 0.0144
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0313 0.163 0.5692
Schistosoma mansoni hypothetical protein 0.0031 0.0117 0.1145
Mycobacterium ulcerans thioesterase TesA 0.0025 0.0084 0.0272
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0123
Toxoplasma gondii type I fatty acid synthase, putative 0.0033 0.0126 0.0464
Schistosoma mansoni patched 1 0.0084 0.0401 0.3934
Loa Loa (eye worm) hypothetical protein 0.0103 0.0502 0.5013
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0041 0.017 0.0629
Giardia lamblia ABC transporter 0.001 0.0002 0.0005
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0003 0.0018
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0003 0.0018
Plasmodium vivax ABC transporter G family member 2, putative 0.001 0.0003 0.001
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.003 0.0111 0.0359
Schistosoma mansoni hypothetical protein 0.0081 0.0384 0.3774
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0042 0.0153
Brugia malayi tubulin alpha-2 chain 0.0017 0.0042 0.0057
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0001 0.000003635
Echinococcus multilocularis epidermal growth factor receptor 0.015 0.0754 0.1799
Plasmodium falciparum multidrug resistance protein 1 0.0011 0.0007 0.0024
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0057 0.0255 0.0351
Brugia malayi Patched family protein 0.0012 0.0013 0.0017
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0123
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0007 0.0015
Echinococcus multilocularis expressed conserved protein 0.0184 0.0938 0.2236
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0035 0.0137 0.1357
Leishmania major alpha tubulin 0.0017 0.0042 0.0144
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0007 0.0045
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0073 0.0256
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0073 0.0237
Echinococcus granulosus tubulin alpha 3 chain 0.0017 0.0042 0.0285
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0312 0.0429
Echinococcus multilocularis protein dispatched 1 0.0096 0.0465 0.1107
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0024 0.0079 0.0257
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0123
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0187 0.1828
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.001 0.0003 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0042 0.0411
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0037 0.0129
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.003 0.0111 0.581
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0117 0.016
Echinococcus multilocularis tubulin alpha chain 0.0017 0.0042 0.0099
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.048 0.0661
Onchocerca volvulus 0.0179 0.091 0.091
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.001 0.0002 0.0006
Brugia malayi Common central domain of tyrosinase family protein 0.0179 0.091 0.1254
Loa Loa (eye worm) hypothetical protein 0.0031 0.0117 0.1164
Echinococcus granulosus epidermal growth factor receptor 0.0081 0.0382 0.2625
Echinococcus multilocularis multidrug resistance protein 1 0.0011 0.0007 0.0015
Giardia lamblia Alpha-tubulin 0.0017 0.0042 0.0154
Echinococcus granulosus tubulin subunit TubB 0.0017 0.0042 0.0285
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0011 0.0007 0.004
Entamoeba histolytica fatty acid elongase, putative 0.0041 0.0168 0.1668
Trichomonas vaginalis ABC transporter, putative 0.0011 0.0007 0.0162
Schistosoma mansoni tyrosinase precursor 0.0179 0.091 0.8945
Echinococcus multilocularis ATP binding cassette sub family B 0.0011 0.0006 0.0012
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.0624 0.0859
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0117 0.0278
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0123
Brugia malayi Protein kinase domain containing protein 0.0048 0.0207 0.0284
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0179 0.091 0.1254
Entamoeba histolytica hypothetical protein 0.0035 0.0137 0.1366
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0011 0.0007 0.0162
Schistosoma mansoni smdr2 0.0011 0.0007 0.0064
Loa Loa (eye worm) hypothetical protein 0.0017 0.0042 0.0411
Leishmania major p-glycoprotein 0.0011 0.0007 0.0014
Entamoeba histolytica hypothetical protein 0.0035 0.0137 0.1366
Loa Loa (eye worm) hypothetical protein 0.0084 0.0401 0.3998
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.048 0.4789
Brugia malayi Patched family protein 0.0012 0.0013 0.0017
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0123
Trichomonas vaginalis abcb9, putative 0.0011 0.0007 0.0162
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.017 0.0594
Trypanosoma cruzi UDP-galactopyranose mutase 0.0041 0.017 0.0629
Echinococcus multilocularis tubulin alpha 3 chain 0.0017 0.0042 0.0099
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0001 0.000003635
Brugia malayi Patched family protein 0.0012 0.0013 0.0017
Loa Loa (eye worm) hypothetical protein 0.0017 0.0042 0.0414
Toxoplasma gondii patched family protein 0.0012 0.0013 0.0046
Entamoeba histolytica P-glycoprotein-2 0.0011 0.0007 0.0065
Chlamydia trachomatis protoporphyrinogen oxidase 0.0041 0.017 0.1039
Brugia malayi Myosin head containing protein 0.0012 0.0013 0.0017
Echinococcus multilocularis multidrug resistance protein 1 0.0011 0.0007 0.0015
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0041 0.017 0.1666
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0032 0.0121 0.0391
Echinococcus granulosus sterol regulatory element binding protein 0.0084 0.0401 0.2755
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0012 0.0014 0.0327
Echinococcus granulosus epidermal growth factor receptor 0.015 0.0754 0.519
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.001 0.0003 0.0011
Echinococcus granulosus multidrug resistance protein 1 0.0011 0.0007 0.0045
Brugia malayi hypothetical protein 0.0012 0.0013 0.0017
Leishmania major alpha tubulin 0.0017 0.0042 0.0144
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0117 0.0278
Loa Loa (eye worm) alpha-tubulin 0.0017 0.0042 0.0414
Mycobacterium ulcerans polyketide synthase Pks13 0.0045 0.0191 0.0618
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0032 0.0121 0.0422
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0011 0.0007 0.0162
Onchocerca volvulus 0.0012 0.0013 0.0012
Entamoeba histolytica P-glycoprotein-2 0.0011 0.0007 0.0065
Onchocerca volvulus 0.0012 0.0013 0.0012
Toxoplasma gondii hypothetical protein 0.0012 0.0013 0.0046
Trypanosoma cruzi ABC transporter, putative 0.001 0.0003 0.001
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0137 0.0187
Plasmodium falciparum telomerase reverse transcriptase 0.0511 0.2695 1
Echinococcus granulosus tubulin alpha chain 0.0017 0.0042 0.0285
Echinococcus multilocularis 0.0046 0.0198 0.0472
Echinococcus multilocularis protein patched 0.0084 0.0401 0.0955
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0123
Loa Loa (eye worm) tubulin alpha 2 0.0013 0.002 0.0197
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0196 0.1001 1
Onchocerca volvulus 0.0179 0.091 0.091
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0037 0.0129
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0123
Echinococcus multilocularis tubulin subunit TubB 0.0017 0.0042 0.0099
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0123
Leishmania major UDP-galactopyranose mutase 0.0041 0.017 0.0619
Mycobacterium ulcerans polyketide synthase Pks9 0.002 0.0056 0.0182
Trypanosoma brucei alpha tubulin 0.0017 0.0042 0.0154
Loa Loa (eye worm) tubulin alpha-3 chain 0.0012 0.0014 0.0131
Brugia malayi Patched family protein 0.0012 0.0013 0.0017
Trypanosoma cruzi UDP-galactopyranose mutase 0.0041 0.017 0.0629
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0401 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.001 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0123
Schistosoma mansoni hypothetical protein 0.0031 0.0117 0.1145
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0011 0.0007 0.0024
Leishmania major alpha tubulin 0.0017 0.0042 0.0144
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0073 0.0237
Schistosoma mansoni multidrug resistance protein 0.0011 0.0007 0.0064
Brugia malayi hypothetical protein 0.0012 0.0013 0.0017
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0584 0.3085 1
Leishmania major alpha tubulin 0.0017 0.0042 0.0144
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0011 0.0007 0.0024
Schistosoma mansoni alpha tubulin 0.0017 0.0042 0.0407
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0123
Loa Loa (eye worm) hypothetical protein 0.0068 0.0312 0.3111
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.0624 0.6225
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0123
Loa Loa (eye worm) patched family protein 0.0012 0.0013 0.0123
Schistosoma mansoni hypothetical protein 0.0031 0.0117 0.1145
Echinococcus granulosus peroxisome assembly protein 26 0.0017 0.0042 0.0285
Brugia malayi protein C24B5.3 0.0012 0.0013 0.0017
Schistosoma mansoni tyrosine kinase 0.0048 0.0207 0.2024
Echinococcus granulosus tubulin alpha chain 0.0017 0.0042 0.0285
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0179 0.091 0.1254
Mycobacterium ulcerans dehydrogenase 0.0041 0.017 0.0551
Loa Loa (eye worm) hypothetical protein 0.0017 0.0042 0.0411
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.001 0.0002 0.0006
Trichomonas vaginalis tubulin beta chain, putative 0.0017 0.0042 0.1034
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0011 0.0007 0.0014
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0117 0.0802
Echinococcus granulosus multidrug resistance protein 1 0.0011 0.0007 0.0045
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0032 0.0121 0.0422
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0011 0.0007 0.0162
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0011 0.0007 0.0025
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0117 0.0802
Loa Loa (eye worm) hypothetical protein 0.0196 0.1001 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0187 0.128
Echinococcus granulosus muscleblind protein 0.018 0.0918 0.6319
Brugia malayi Patched family protein 0.0012 0.0013 0.0017
Brugia malayi hypothetical protein 0.0012 0.0013 0.0017
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0073 0.3844
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0117 0.1164
Mycobacterium tuberculosis Possible oxidoreductase 0.0041 0.017 0.0594
Brugia malayi hypothetical protein 0.0041 0.017 0.0233
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0123
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.0111 0.0359
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0045 0.0191 0.0665
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0032 0.0121 0.6337
Onchocerca volvulus 0.0179 0.091 0.091
Mycobacterium ulcerans hypothetical protein 0.0023 0.0073 0.0237
Brugia malayi tubulin alpha chain - mouse 0.0017 0.0042 0.0057
Toxoplasma gondii patched family protein 0.0012 0.0013 0.0046
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0011 0.0007 0.0162
Loa Loa (eye worm) acyl carrier protein 0.0014 0.0024 0.0228
Trichomonas vaginalis ABC transporter, putative 0.0011 0.0007 0.0162
Onchocerca volvulus 0.0011 0.0007 0.0006
Schistosoma mansoni tyrosine kinase 0.0081 0.0382 0.3748
Onchocerca volvulus 0.0012 0.0013 0.0012
Echinococcus granulosus expressed conserved protein 0.0184 0.0938 0.6451
Loa Loa (eye worm) TAR-binding protein 0.0126 0.0624 0.6225
Echinococcus multilocularis Tubulin alpha 1 chain 0.0017 0.0042 0.0099
Loa Loa (eye worm) TK/EGFR protein kinase 0.015 0.0754 0.7533
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0123
Brugia malayi Patched related family protein 12 0.0012 0.0013 0.0017
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0313 0.163 0.5284
Loa Loa (eye worm) fatty acid synthase 0.003 0.0109 0.1078
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0187 0.128
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0199 0.1018 1
Schistosoma mansoni hypothetical protein 0.0031 0.0117 0.1145
Onchocerca volvulus Protein patched homolog 0.0012 0.0013 0.0012
Brugia malayi Patched family protein 0.0012 0.0013 0.0017
Loa Loa (eye worm) hypothetical protein 0.0023 0.0073 0.0725
Loa Loa (eye worm) hypothetical protein 0.0041 0.017 0.1693
Leishmania major alpha tubulin 0.0017 0.0042 0.0144
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0543 0.2865 1
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.001 0.0002 0.0007
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.001 0.0005 0.0017
Onchocerca volvulus 0.0179 0.091 0.091
Echinococcus multilocularis tubulin alpha chain 0.0017 0.0042 0.0099
Onchocerca volvulus 0.0035 0.0137 0.0136
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0045 0.0191 0.0665
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0313 0.163 0.605
Leishmania major alpha tubulin 0.0017 0.0042 0.0144
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0123
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0035 0.0137 0.0477
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0624 0.6125
Brugia malayi Patched family protein 0.0012 0.0013 0.0017
Brugia malayi CHE-14 protein 0.0084 0.0401 0.0551
Echinococcus granulosus tubulin alpha 1C chain 0.0017 0.0042 0.0285
Leishmania major alpha tubulin 0.0017 0.0042 0.0144
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0011 0.0007 0.0162
Brugia malayi hypothetical protein 0.0012 0.0013 0.0017
Echinococcus granulosus Protein patched homolog 1 0.0084 0.0401 0.2755
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0073 0.0259
Mycobacterium ulcerans monoamine oxidase 0.0041 0.017 0.0551
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0012 0.0015 0.0051
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0007 0.0045
Plasmodium falciparum protoporphyrinogen oxidase 0.0041 0.017 0.0629
Trichomonas vaginalis tubulin beta chain, putative 0.0017 0.0042 0.1034
Loa Loa (eye worm) hypothetical protein 0.018 0.0918 0.917
Trypanosoma cruzi ATP-binding cassette protein, putative 0.001 0.0003 0.001
Leishmania major alpha tubulin 0.0017 0.0042 0.0144
Brugia malayi multidrug resistance protein 3 0.0011 0.0007 0.0009
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0137 0.1344
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0073 0.0259
Entamoeba histolytica fatty acid elongase, putative 0.0041 0.0168 0.1668
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.001 0.0003 0.0011
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0313 0.163 0.605
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0007 0.0015
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0042 0.0136
Onchocerca volvulus 0.0023 0.0073 0.0073
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0137 0.0326
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0123
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0048 0.0207 0.1417
Loa Loa (eye worm) TK/INSR protein kinase 0.0048 0.0207 0.2057
Trichomonas vaginalis tubulin beta chain, putative 0.0017 0.0042 0.1034
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0013 0.002 0.0197
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0123
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.003 0.0111 0.0387
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0007 0.0045
Loa Loa (eye worm) hypothetical protein 0.0017 0.004 0.039
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0011 0.0007 0.0162
Schistosoma mansoni tyrosine kinase 0.0048 0.0207 0.2024
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0017 0.0041 0.0143
Loa Loa (eye worm) hypothetical protein 0.0023 0.0073 0.0725
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.001 0.0002 0.0002
Echinococcus multilocularis 0.0041 0.017 0.0404
Trichomonas vaginalis abcb9, putative 0.0011 0.0007 0.0162
Echinococcus multilocularis muscleblind protein 1 0.018 0.0918 0.219
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0011 0.0006 0.0036
Trichomonas vaginalis tubulin beta chain, putative 0.0017 0.0042 0.1034
Brugia malayi Tubulin alpha chain 0.0017 0.0042 0.0057
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0073 0.0237
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.001 0.0002 0.0006
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0011 0.0007 0.0162
Echinococcus multilocularis peroxisome assembly protein 26 0.0017 0.0042 0.0099
Mycobacterium leprae Polyketide synthase Pks13 0.0045 0.0191 1
Trypanosoma cruzi alpha tubulin, putative 0.0017 0.0042 0.0154
Loa Loa (eye worm) hypothetical protein 0.0041 0.017 0.1693
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0131
Brugia malayi RNA binding protein 0.0126 0.0624 0.0859
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0041 0.017 0.0629
Trypanosoma brucei telomerase reverse transcriptase 0.0511 0.2695 1
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0025 0.0084 0.4398
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0511 0.2695 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.001 0.0002 0.0007
Plasmodium vivax patched family protein, putative 0.0012 0.0013 0.0046
Entamoeba histolytica fatty acid elongase, putative 0.0041 0.0168 0.1668
Schistosoma mansoni tubulin subunit alpha 0.0017 0.0042 0.0407
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0042 0.0153
Brugia malayi Tubulin alpha-2 chain 0.0017 0.0042 0.0057
Loa Loa (eye worm) hypothetical protein 0.0023 0.0073 0.0725
Brugia malayi hypothetical protein 0.0035 0.0137 0.0188
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0025 0.0081 0.0284
Schistosoma mansoni alpha tubulin 0.0017 0.0042 0.0407
Mycobacterium ulcerans polyketide synthase 0.0032 0.0121 0.0391
Brugia malayi amine oxidase, flavin-containing family protein 0.0041 0.017 0.0233
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0013 0.002 0.0492
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0073 0.01
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0073 0.01
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0011 0.0007 0.0162
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0624 0.6125
Brugia malayi protein C24B5.3 0.0012 0.0013 0.0017
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0073 0.0237
Loa Loa (eye worm) patched family protein 0.0012 0.0013 0.0123
Toxoplasma gondii patched family protein 0.0012 0.0013 0.0046
Loa Loa (eye worm) ShTK domain-containing protein 0.0179 0.091 0.909
Toxoplasma gondii histone lysine-specific demethylase 0.0041 0.017 0.0629
Echinococcus granulosus Niemann Pick C1 protein 0.0196 0.1001 0.6891
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0001 0.00000034704
Plasmodium falciparum lipid/sterol:H+ symporter 0.0012 0.0013 0.0046
Brugia malayi AMP-binding enzyme family protein 0.001 0.0004 0.0004
Echinococcus granulosus tubulin alpha chain 0.0017 0.0042 0.0285
Brugia malayi Patched family protein 0.0012 0.0013 0.0017
Echinococcus granulosus tubulin alpha 3 chain 0.0017 0.0042 0.0285
Toxoplasma gondii RNA-directed DNA polymerase 0.0511 0.2695 1
Loa Loa (eye worm) alpha-tubulin 0.0017 0.0042 0.0414
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0123
Loa Loa (eye worm) hypothetical protein 0.0099 0.048 0.4789
Schistosoma mansoni alpha tubulin 0.0017 0.0042 0.0407
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0001 0.0002
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.0111 0.0359
Echinococcus multilocularis hypothetical protein 0.0017 0.0042 0.0099
Entamoeba histolytica tubulin alpha chain, putative 0.0017 0.0042 0.0414
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.001 0.0003 0.0011
Trichomonas vaginalis tubulin epsilon chain, putative 0.0017 0.0042 0.1034
Giardia lamblia Alpha-tubulin 0.0017 0.0042 0.0154
Echinococcus multilocularis tubulin alpha 1C chain 0.0017 0.0042 0.0099
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0624 0.6125
Entamoeba histolytica P-glyco protein 6, putative 0.0011 0.0007 0.0065
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0007 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0123
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0187 0.1858
Echinococcus granulosus replication factor c subunit 1 0.001 0.0001 0.0000010013
Loa Loa (eye worm) RNA binding protein 0.0126 0.0624 0.6225
Schistosoma mansoni hypothetical protein 0.0068 0.0312 0.3061
Echinococcus multilocularis tar DNA binding protein 0.0126 0.0624 0.1487
Schistosoma mansoni tyrosine kinase 0.008 0.0377 0.3703
Loa Loa (eye worm) hypothetical protein 0.0179 0.091 0.909
Loa Loa (eye worm) tyrosinase 1 0.0179 0.091 0.909
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.002 0.0056 0.2941
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0032 0.0121 0.6337
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0029 0.0106 0.0369
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.003 0.0111 0.0152
Trichomonas vaginalis tubulin beta chain, putative 0.0017 0.0042 0.1034
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0003 0.0018
Schistosoma mansoni hypothetical protein 0.0081 0.0384 0.3774
Entamoeba histolytica fatty acid elongase, putative 0.0041 0.0168 0.1668
Entamoeba histolytica P-glycoprotein-1 0.0011 0.0007 0.0065
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0313 0.163 1
Echinococcus multilocularis muscleblind protein 0.018 0.0918 0.219
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0123
Loa Loa (eye worm) hypothetical protein 0.0051 0.0226 0.2247
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0011 0.0007 0.0162
Trichomonas vaginalis tubulin epsilon chain, putative 0.0017 0.0042 0.1034
Loa Loa (eye worm) tubulin alpha 2 0.0013 0.002 0.0197
Brugia malayi Patched family protein 0.0012 0.0013 0.0017
Mycobacterium ulcerans polyketide synthase 0.003 0.0111 0.0359
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0187 0.1828
Plasmodium vivax hypothetical protein, conserved 0.0041 0.017 0.0629
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0073 0.0725
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.001 0.0002 0.0006
Mycobacterium ulcerans oxidoreductase 0.0041 0.017 0.0551
Onchocerca volvulus 0.0012 0.0013 0.0012
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.003 0.0111 0.581
Brugia malayi Telomerase reverse transcriptase 0.136 0.7255 1
Trichomonas vaginalis ABC transporter, putative 0.0011 0.0007 0.0162
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.079 0.419 1
Echinococcus granulosus tubulin alpha 1C chain 0.0017 0.0042 0.0285
Echinococcus multilocularis tubulin alpha 1C chain 0.0017 0.0042 0.0099
Echinococcus granulosus alpha tubulin 0.0017 0.0042 0.0285
Onchocerca volvulus 0.0041 0.017 0.0169
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0022 0.0065 0.0228
Entamoeba histolytica P-glycoprotein 5, putative 0.0011 0.0007 0.0065
Brugia malayi Patched family protein 0.0012 0.0013 0.0017
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0073 0.0237
Schistosoma mansoni amine oxidase 0.0041 0.017 0.1666
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0187 0.0444
Trichomonas vaginalis abcb9, putative 0.0011 0.0007 0.0162
Echinococcus multilocularis protoporphyrinogen oxidase 0.0041 0.017 0.0404
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0313 0.163 0.5284
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0029 0.0106 0.0369
Brugia malayi Niemann-Pick C1 protein precursor 0.0196 0.1001 0.1379
Entamoeba histolytica P-glycoprotein-2, putative 0.0011 0.0007 0.0065
Echinococcus granulosus tubulin alpha chain 0.0017 0.0042 0.0285
Echinococcus granulosus lysine specific histone demethylase 1A 0.0041 0.017 0.1166
Echinococcus granulosus lysine specific histone demethylase 1A 0.0041 0.017 0.1166
Echinococcus granulosus tubulin alpha chain 0.0017 0.0042 0.0285
Entamoeba histolytica fatty acid elongase, putative 0.0041 0.0168 0.1668
Trypanosoma brucei ABC transporter, putative 0.001 0.0003 0.001
Entamoeba histolytica P-glycoprotein-5 0.0011 0.0007 0.0065
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0123
Brugia malayi Patched protein homolog 1 0.0012 0.0013 0.0017
Echinococcus granulosus multidrug resistance protein 1 0.0011 0.0007 0.0045
Entamoeba histolytica hypothetical protein 0.0035 0.0137 0.1366
Onchocerca volvulus 0.0012 0.0013 0.0012
Echinococcus granulosus GPCR family 2 0.0031 0.0117 0.0802
Trichomonas vaginalis tubulin beta chain, putative 0.0017 0.0042 0.1034
Brugia malayi ABC transporter family protein 0.0011 0.0007 0.0009
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0007 0.0015
Plasmodium vivax tubulin alpha chain, putative 0.0017 0.0042 0.0154
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0041 0.017 0.0629
Loa Loa (eye worm) hypothetical protein 0.0041 0.017 0.1693
Mycobacterium tuberculosis Probable thioesterase TesA 0.0025 0.0084 0.0293
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0007 0.0015
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0123
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0511 0.2695 1
Echinococcus multilocularis epidermal growth factor receptor 0.0081 0.0382 0.091
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0073 0.0237
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0187 0.0256
Echinococcus multilocularis tubulin alpha 3 chain 0.0017 0.0042 0.0099
Treponema pallidum DNA ligase (lig) 0.001 0.0001 0.5
Schistosoma mansoni tyrosinase precursor 0.0179 0.091 0.8945
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0048 0.0207 0.0491
Toxoplasma gondii alpha-tubulin I, putative 0.0017 0.0042 0.0154
Echinococcus granulosus Tubulin alpha 1 chain 0.0017 0.0042 0.0285
Echinococcus granulosus Niemann Pick C1 protein 0.028 0.1453 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.0111 0.0359
Toxoplasma gondii patched family protein 0.0012 0.0013 0.0046
Loa Loa (eye worm) hypothetical protein 0.0041 0.017 0.1693
Brugia malayi Patched family protein 0.0012 0.0013 0.0017
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0001 0.00000053973
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0123
Echinococcus granulosus Tubulin alpha 1 chain 0.0017 0.0042 0.0285
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.001 0.0002 0.0105
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0037 0.0129
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0042 0.0146
Trypanosoma brucei ATP-binding cassette protein, putative 0.001 0.0003 0.001
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0624 0.6125
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0007 0.0045
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0011 0.0007 0.0162
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0123
Loa Loa (eye worm) hypothetical protein 0.018 0.0918 0.917
Onchocerca volvulus 0.001 0.0002 0.0001
Brugia malayi Tubulin alpha-2 chain 0.0017 0.0042 0.0057
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0123
Onchocerca volvulus 0.0012 0.0013 0.0012
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0041 0.017 0.0629
Plasmodium vivax tubulin alpha chain, putative 0.0017 0.0042 0.0154
Plasmodium falciparum alpha tubulin 1 0.0017 0.0042 0.0154
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0003 0.0006
Echinococcus granulosus insulin receptor 0.0048 0.0207 0.1417
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0003 0.0006
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0073 0.0259
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0179 0.091 0.1254
Loa Loa (eye worm) tubulin alpha chain 0.0017 0.0042 0.0414
Loa Loa (eye worm) patched family protein 0.0012 0.0013 0.0123
Loa Loa (eye worm) hypothetical protein 0.0017 0.0042 0.0411
Trichomonas vaginalis taga, putative 0.0011 0.0007 0.0162
Toxoplasma gondii type I fatty acid synthase, putative 0.0021 0.0064 0.0236
Echinococcus multilocularis tubulin alpha chain 0.0017 0.0042 0.0099
Echinococcus granulosus Tubulin alpha 1 chain 0.0017 0.0042 0.0285
Loa Loa (eye worm) patched family protein 0.0012 0.0013 0.0123
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0117 0.016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0123
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0073 0.0256
Loa Loa (eye worm) hypothetical protein 0.0013 0.002 0.0197
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0037 0.0129
Leishmania major alpha tubulin 0.0017 0.0042 0.0144
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0011 0.0007 0.0162
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0011 0.0007 0.0162
Toxoplasma gondii alpha tubulin TUBA1 0.0017 0.0042 0.0154
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0073 0.0237
Brugia malayi alpha-tubulin 0.0017 0.0042 0.0057
Loa Loa (eye worm) tubulin alpha-2 chain 0.0017 0.0042 0.0414
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0123
Brugia malayi Patched family protein 0.0012 0.0013 0.0017
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0003 0.0006
Schistosoma mansoni tyrosine kinase 0.008 0.0377 0.3703
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0016 0.0036 0.0131
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0011 0.0007 0.0162
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0011 0.0007 0.0162
Onchocerca volvulus 0.0012 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0123
Leishmania major alpha tubulin 0.0017 0.0042 0.0144
Plasmodium falciparum alpha tubulin 2 0.0017 0.0042 0.0154
Leishmania major alpha tubulin 0.0017 0.0042 0.0144
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0313 0.163 0.5284
Mycobacterium ulcerans acyl-CoA synthetase 0.001 0.0002 0.0006
Entamoeba histolytica ABC transporter, putative 0.001 0.0003 0.0027
Loa Loa (eye worm) hypothetical protein 0.0041 0.017 0.1693
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0032 0.0121 0.0391
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0032 0.0121 0.0422
Schistosoma mansoni tubulin subunit alpha 0.0017 0.0042 0.0407
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.002 0.0056 0.0182
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0001 0.000003635
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0011 0.0007 0.0162
Entamoeba histolytica hypothetical protein 0.0035 0.0137 0.1366
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0024 0.0079 0.4155
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.001 0.0003 0.001
Trypanosoma brucei alpha tubulin 0.0017 0.0042 0.0154
Trypanosoma brucei alpha tubulin 0.0017 0.0042 0.0154
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0123
Mycobacterium ulcerans thioesterase 0.0025 0.0084 0.0272
Echinococcus multilocularis tubulin alpha chain 0.0017 0.0042 0.0099
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0041 0.017 0.1666
Mycobacterium leprae Probable polyketide synthase Pks1 0.0032 0.0121 0.6337
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0001 0.004
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0123
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0584 0.3085 1
Brugia malayi Patched family protein 0.0012 0.0013 0.0017
Echinococcus multilocularis Niemann Pick C1 protein 0.0196 0.1001 0.2388
Schistosoma mansoni hypothetical protein 0.0081 0.0384 0.3774
Brugia malayi ShTK domain containing protein 0.0179 0.091 0.1254
Echinococcus multilocularis Tubulin alpha 1 chain 0.0017 0.0042 0.0099
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0001 0.0000014299
Onchocerca volvulus Fatty acid synthase homolog 0.0054 0.024 0.024
Brugia malayi Patched related family protein 4 0.0012 0.0013 0.0017
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0017 0.0042 0.1034
Schistosoma mansoni hypothetical protein 0.0081 0.0384 0.3774
Entamoeba histolytica tubulin alpha-1 chain 0.0017 0.0042 0.0414
Plasmodium falciparum ABC transporter G family member 2 0.001 0.0003 0.001
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0011 0.0007 0.0162
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0179 0.091 0.1254
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0011 0.0007 0.0162
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0137 0.0941
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0011 0.0007 0.0162
Schistosoma mansoni amine oxidase 0.0041 0.017 0.1666
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0187 0.1828
Schistosoma mansoni multidrug resistance protein 0.0011 0.0007 0.0064
Echinococcus multilocularis insulin receptor 0.0048 0.0207 0.0491
Echinococcus multilocularis tubulin alpha chain 0.0017 0.0042 0.0099
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0011 0.0007 0.0162
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0123
Trypanosoma brucei alpha tubulin 0.0017 0.0042 0.0154
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0041 0.017 0.8925

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 9.93 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits of the thioesterase domain of fatty acid synthase via a fluorescence intensity assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 13 uM PubChem BioAssay. Dose response confirmation of small molecule inhibitors of the thioesterase domain of fatty acid synthase via a kinetic, fluorescence intensity assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0415 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 3.9811 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 22.3872 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 75.6863 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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