Detailed information for compound 1443888

Basic information

Technical information
  • TDR Targets ID: 1443888
  • Name: [2-oxo-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)amin o]ethyl] 4-oxo-4-phenylbutanoate
  • MW: 379.366 | Formula: C20H17N3O5
  • H donors: 1 H acceptors: 5 LogP: 2.09 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CCC(=O)c1ccccc1)OCC(=O)Nc1nnc(o1)c1ccccc1
  • InChi: 1S/C20H17N3O5/c24-16(14-7-3-1-4-8-14)11-12-18(26)27-13-17(25)21-20-23-22-19(28-20)15-9-5-2-6-10-15/h1-10H,11-13H2,(H,21,23,25)
  • InChiKey: PHMHMJGBJBXLRY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-oxo-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)amino]ethyl] 4-oxo-4-phenyl-butanoate
  • 4-oxo-4-phenylbutanoic acid [2-oxo-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)amino]ethyl] ester
  • 4-keto-4-phenyl-butyric acid [2-keto-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)amino]ethyl] ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major mitochondrial DNA topoisomerase II 0.0014 0.0102 0.0846
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0029 0.0005
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0014 0.0102 0.0846
Plasmodium vivax DNA gyrase subunit B, putative 0.0014 0.0102 0.0846
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0191 0.1918
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0191 0.2504
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0014 0.0102 0.1105
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0014 0.0102 0.0846
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0009 0.0032 0.0009
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0009 0.0032 0.0009
Echinococcus multilocularis cation transporting atpase worm 0.0009 0.0032 0.0009
Echinococcus granulosus cation transporting atpase worm 0.0009 0.0032 0.0009
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0056 0.0033
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0191 0.0168
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0032 0.0009
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0329 0.0306
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0009 0.0032 0.0009
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0009 0.0032 0.0019
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0033 0.0368 0.4069
Mycobacterium ulcerans putative regultory protein 0.0014 0.0102 0.1105
Leishmania major developmentally regulated phosphoprotein-like protein 0.0014 0.0102 0.0846
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0102 0.0846
Trypanosoma brucei heat shock protein 90, putative 0.0069 0.0859 1
Echinococcus multilocularis phospholipid transporting ATPase VA 0.0009 0.0032 0.0009
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0023 0.0023
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0008 0.0023 0.0023
Trypanosoma brucei Metacaspase-4 0.0056 0.0685 0.7892
Trypanosoma cruzi metacaspase, putative 0.0056 0.0685 0.7892
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0056 0.0685 0.2016
Trypanosoma cruzi metacaspase 5, putative 0.0056 0.0685 0.7892
Echinococcus granulosus cation transporting ATPase 13A3 0.0009 0.0032 0.0009
Leishmania major heat shock protein 83-1 0.0069 0.0859 1
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0014 0.0102 0.1105
Plasmodium falciparum DNA topoisomerase 2 0.0014 0.0102 0.0846
Trypanosoma brucei heat shock protein, putative 0.0069 0.0859 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0056 0.0072
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0056 0.0072
Echinococcus granulosus cpg binding protein 0.0032 0.0352 0.033
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0014 0.0102 0.0079
Brugia malayi Temporarily assigned gene name protein 44 0.0029 0.0306 0.0617
Echinococcus multilocularis survival motor neuron protein 1 0.0249 0.3366 0.3351
Brugia malayi CXXC zinc finger family protein 0.003 0.0328 0.0665
Entamoeba histolytica hypothetical protein 0.0038 0.0434 0.4867
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0014 0.0102 0.0291
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0191 0.0191
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0029 0.0005
Entamoeba histolytica DNA topoisomerase II, putative 0.0014 0.0102 0.0846
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0191 0.1918
Toxoplasma gondii heat shock protein 75, putative 0.0028 0.0298 0.3215
Schistosoma mansoni microtubule-associated protein tau 0.0727 1 1
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0014 0.0102 1
Plasmodium vivax endoplasmin, putative 0.0069 0.0859 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0056 0.0071
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0014 0.0102 0.0171
Trypanosoma brucei Heat shock protein 83, putative 0.0069 0.0859 1
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0685 0.2016
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0029 0.0005
Schistosoma mansoni caspase-7 (C14 family) 0.0056 0.0685 0.0685
Chlamydia trachomatis DNA gyrase subunit B 0.0014 0.0102 1
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0014 0.0102 0.0291
Echinococcus multilocularis dna polymerase kappa 0.002 0.0191 0.0168
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0139 0.1299
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0011 0.0057 0.0301
Brugia malayi intermediate filament protein 0.0028 0.0303 0.0609
Schistosoma mansoni caspase-3 (C14 family) 0.0209 0.2812 0.2812
Leishmania major metacaspase, putative 0.0056 0.0685 0.7892
Toxoplasma gondii Hsp90 domain-containing protein 0.0028 0.0298 0.3215
Leishmania major heat shock protein 83-1 0.0069 0.0859 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0056 0.0071
Loa Loa (eye worm) hypothetical protein 0.0011 0.0056 0.0071
Loa Loa (eye worm) hypothetical protein 0.0249 0.3366 0.7287
Leishmania major heat shock protein 83-1 0.0069 0.0859 1
Leishmania major heat shock protein 83-1 0.0069 0.0859 1
Onchocerca volvulus 0.0051 0.0614 0.1737
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0139 0.0116
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0354 0.0331
Trypanosoma cruzi heat shock protein, putative 0.0028 0.0298 0.3215
Echinococcus granulosus heat shock protein 0.0069 0.0859 0.0837
Plasmodium falciparum heat shock protein 90, putative 0.0028 0.0298 0.3215
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0543 0.0543
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0056 0.0033
Mycobacterium ulcerans DNA gyrase subunit B 0.0014 0.0102 0.1105
Schistosoma mansoni hypothetical protein 0.0038 0.0434 0.0434
Echinococcus multilocularis copper transporting ATPase 1 0.0009 0.0032 0.0009
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0056 0.0685 0.7892
Loa Loa (eye worm) calcium ATPase 0.0009 0.0032 0.0019
Trypanosoma cruzi metacaspase 5, putative 0.0056 0.0685 0.7892
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0434 0.0434
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0056 0.0033
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0191 0.1918
Leishmania major heat shock protein 83-1 0.0069 0.0859 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0354 0.0721
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0028 0.0298 0.0275
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0191 0.1918
Schistosoma mansoni DNA topoisomerase II 0.0014 0.0102 0.0102
Trichomonas vaginalis heat shock protein, putative 0.0055 0.0665 0.1959
Leishmania major heat shock protein 83-1 0.0069 0.0859 1
Trypanosoma brucei metacaspase 5, putative 0.0056 0.0685 0.7892
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0014 0.0102 0.0209
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0056 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0685 0.2016
Brugia malayi tumor suppressor. 0.0339 0.4611 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.2961 0.6403
Echinococcus granulosus caspase 2 0.0056 0.0685 0.0663
Loa Loa (eye worm) hypothetical protein 0.0009 0.0032 0.0019
Trypanosoma brucei heat shock protein, putative 0.0069 0.0859 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0042 0.049 0.0468
Plasmodium vivax heat shock protein, putative 0.0028 0.0298 0.3215
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0191 0.0364
Loa Loa (eye worm) hypothetical protein 0.0056 0.0685 0.1441
Echinococcus granulosus caspase 3 0.0153 0.2035 0.2017
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0056 0.0033
Schistosoma mansoni ATPase 0.0009 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0029 0.0306 0.0306
Leishmania major hypothetical protein, conserved 0.0014 0.0102 0.0846
Echinococcus multilocularis heat shock protein 90 0.0055 0.0665 0.0643
Brugia malayi kinase, mitochondrial precursor 0.0014 0.0102 0.0171
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0139 0.0116
Echinococcus multilocularis microtubule associated protein 2 0.0727 1 1
Schistosoma mansoni cation-transporting atpase worm 0.0009 0.0032 0.0032
Toxoplasma gondii DNA topoisomerase 2, putative 0.0014 0.0102 0.0846
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0014 0.0102 0.0171
Loa Loa (eye worm) hypothetical protein 0.0036 0.0413 0.085
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0056 0.0056
Schistosoma mansoni endoplasmin 0.0069 0.0859 0.0859
Brugia malayi heat shock protein 90 0.0069 0.0859 0.1821
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0014 0.0102 0.1105
Trichomonas vaginalis ATPase, class I, type 8B, putative 0.0009 0.0032 0.0084
Plasmodium vivax SET domain protein, putative 0.0032 0.0354 0.3895
Loa Loa (eye worm) tumor suppressor 0.0339 0.4611 1
Loa Loa (eye worm) E1-E2 ATPase 0.0009 0.0032 0.0019
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0303 0.0609
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0139 0.1299
Loa Loa (eye worm) hypothetical protein 0.0093 0.1197 0.2558
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0056 0.0071
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0056 0.0685 0.2016
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0056 0.0071
Onchocerca volvulus 0.0032 0.0354 0.0962
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0009 0.0032 0.0019
Echinococcus granulosus lamin 0.0028 0.0303 0.028
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0191 0.1918
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0385 0.4273
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0056 0.0033
Loa Loa (eye worm) hypothetical protein 0.0009 0.0032 0.0019
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0009 0.0032 0.0009
Brugia malayi hypothetical protein 0.0249 0.3366 0.7287
Treponema pallidum heat shock protein 90 0.0055 0.0665 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0056 0.0056
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0056 0.0033
Schistosoma mansoni copper ABC transporter ATPase 0.0009 0.0032 0.0032
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0014 0.0102 0.1105
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0014 0.0102 0.0846
Schistosoma mansoni hypothetical protein 0.0029 0.0306 0.0306
Loa Loa (eye worm) hypothetical protein 0.0011 0.0056 0.0071
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0056 0.0071
Echinococcus multilocularis musashi 0.0028 0.0303 0.028
Echinococcus granulosus dnaJ subfamily B 0.0431 0.589 0.588
Loa Loa (eye worm) hypothetical protein 0.0012 0.0077 0.0116
Trypanosoma brucei heat shock protein, putative 0.0069 0.0859 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0056 0.0071
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0139 0.1299
Echinococcus granulosus dna polymerase eta 0.0047 0.0563 0.0541
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0042 0.049 0.1017
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0014 0.0102 0.0846
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0056 0.0071
Brugia malayi E1-E2 ATPase family protein 0.0009 0.0032 0.0019
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0014 0.0102 0.1105
Chlamydia trachomatis DNA gyrase subunit B 0.0014 0.0102 1
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0032 0.0009
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0042 0.049 0.0468
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0009 0.0032 0.0084
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0056 0.0033
Schistosoma mansoni heat shock protein 0.0069 0.0859 0.0859
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0055 0.0665 0.7659
Echinococcus multilocularis heat shock protein 0.0069 0.0859 0.0837
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0139 0.1299
Mycobacterium ulcerans two component regulator - sensor kinase 0.0014 0.0102 0.1105
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0385 0.4273
Trypanosoma brucei metacaspase MCA2 0.0056 0.0685 0.7892
Trypanosoma brucei heat shock protein, putative 0.0069 0.0859 1
Plasmodium falciparum heat shock protein 90 0.0069 0.0859 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0452 0.1327
Echinococcus granulosus voltage gated potassium channel 0.0012 0.0077 0.0054
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.072 0.8321
Trypanosoma cruzi heat shock protein 90, putative 0.0055 0.0665 0.7659
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0191 0.1918
Schistosoma mansoni lamin 0.0028 0.0303 0.0303
Trypanosoma cruzi metacaspase, putative 0.0056 0.0685 0.7892
Leishmania major heat shock protein 83-1 0.0069 0.0859 1
Trichomonas vaginalis DNA topoisomerase II, putative 0.0014 0.0102 0.0291
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0191 0.0554
Echinococcus granulosus survival motor neuron protein 1 0.0249 0.3366 0.3351
Loa Loa (eye worm) TOPoisomerase family member 0.0014 0.0102 0.0171
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0209 0.2812 0.2795
Trypanosoma brucei heat shock protein, putative 0.0069 0.0859 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0191 0.0191
Leishmania major heat shock protein 83-1 0.0069 0.0859 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0139 0.1299
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0685 0.2016
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0056 0.0685 0.2016
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0139 0.1299
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0032 0.0084
Schistosoma mansoni lamin 0.0028 0.0303 0.0303
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0056 0.0685 0.7892
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0009 0.0032 0.0032
Leishmania major heat shock protein 83-1 0.0069 0.0859 1
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0491 0.1445
Entamoeba histolytica hypothetical protein 0.0038 0.0434 0.4867
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0191 0.0364
Leishmania major DNA polymerase eta, putative 0.0047 0.0563 0.6422
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0434 0.0412
Trichomonas vaginalis ATPase, class VI, type 11C, putative 0.0009 0.0032 0.0084
Loa Loa (eye worm) hypothetical protein 0.0029 0.0306 0.0617
Onchocerca volvulus 0.0028 0.0303 0.0808
Brugia malayi hypothetical protein 0.0093 0.1197 0.2558
Toxoplasma gondii heat shock protein HSP90 0.0069 0.0859 1
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0191 0.2504
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0191 0.0554
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0056 0.0056
Trypanosoma cruzi DNA topoisomerase II, putative 0.0014 0.0102 0.0846
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0032 0.0009
Onchocerca volvulus 0.0052 0.0632 0.179
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0032 0.0084
Echinococcus multilocularis cpg binding protein 0.0032 0.0352 0.033
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0054 0.0067
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0056 0.0071
Brugia malayi Pre-SET motif family protein 0.022 0.2961 0.6403
Trichomonas vaginalis receptor histidine kinase, putative 0.0014 0.0102 0.0291
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0385 0.4273
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0056 0.0033
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0055 0.0665 1
Brugia malayi hypothetical protein 0.0029 0.0306 0.0617
Plasmodium vivax metacaspase 1, putative 0.0056 0.0685 0.7892
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0014 0.0102 0.1105
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0056 0.0071
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0014 0.0102 0.0741
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.0563 0.1176
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0354 0.0354
Trypanosoma brucei heat shock protein, putative 0.0069 0.0859 1
Brugia malayi Probable cation-transporting ATPase C10C6.6 in chromosome IV 0.0009 0.0032 0.0019
Echinococcus multilocularis lamin 0.0028 0.0303 0.028
Trypanosoma brucei unspecified product 0.0014 0.0103 0.0859
Plasmodium vivax heat shock protein 86, putative 0.0069 0.0859 1
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0077 0.0077
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0009 0.0032 0.0019
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0056 0.0072
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0057 0.0301
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0012 0.0077 0.0054
Schistosoma mansoni endoplasmin 0.0069 0.0859 0.0859
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0014 0.0102 0.1105
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0014 0.0102 0.1105
Trichomonas vaginalis sensor histidine kinase, putative 0.0014 0.0102 0.0291
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0056 0.0685 0.2016
Loa Loa (eye worm) endoplasmin 0.0069 0.0859 0.1821
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0014 0.0102 0.0846
Trypanosoma cruzi metacaspase, putative 0.0056 0.0685 0.7892
Brugia malayi potential phospholipid-transporting ATPase IIB, putative 0.0009 0.0032 0.0019
Echinococcus multilocularis tumor protein p63 0.0356 0.485 0.4838
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0056 0.0056
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0056 0.0033
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0328 0.0665
Echinococcus multilocularis dnaJ subfamily B 0.0431 0.589 0.588
Mycobacterium tuberculosis Possible two component sensor kinase 0.0014 0.0102 0.1105
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0103 0.0859
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0139 0.0116
Echinococcus multilocularis voltage gated potassium channel 0.0012 0.0077 0.0054
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0032 0.0009
Loa Loa (eye worm) hypothetical protein 0.0009 0.0032 0.0019
Loa Loa (eye worm) hypothetical protein 0.0011 0.0056 0.0071
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0014 0.0102 0.1105
Trypanosoma cruzi Heat shock protein 83, putative 0.0069 0.0859 1
Trypanosoma cruzi DNA topoisomerase II, putative 0.0014 0.0102 0.0846
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0191 0.1918
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0685 0.2016
Echinococcus multilocularis caspase 0.0209 0.2812 0.2795
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0191 0.1918
Trypanosoma cruzi metacaspase, putative 0.0056 0.0685 0.7892
Echinococcus granulosus heat shock protein 90 0.0069 0.0859 0.0837
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0056 0.0056
Echinococcus multilocularis caspase 3 0.0153 0.2035 0.2017
Trypanosoma cruzi heat shock protein 90, putative 0.004 0.0469 0.529
Loa Loa (eye worm) hypothetical protein 0.0009 0.0032 0.0019
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0139 0.1299
Echinococcus multilocularis protein quaking 0.0029 0.0306 0.0283
Leishmania major heat shock protein 83-1 0.0069 0.0859 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0191 0.1918
Brugia malayi Endoplasmin precursor 0.0069 0.0859 0.1821
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0191 0.1918
Loa Loa (eye worm) heat shock protein 90 0.0069 0.0859 0.1821
Schistosoma mansoni cpg binding protein 0.0032 0.0352 0.0352
Schistosoma mansoni hypothetical protein 0.0431 0.589 0.589
Trypanosoma brucei heat shock protein, putative 0.0069 0.0859 1
Giardia lamblia DINP protein human, muc B family 0.002 0.0191 0.1918
Echinococcus granulosus copper transporting ATPase 1 0.0009 0.0032 0.0009
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0056 0.0056
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0056 0.0056
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0009 0.0032 0.0009
Loa Loa (eye worm) hypothetical protein 0.0011 0.0056 0.0071
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0029 0.0005
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0014 0.0102 0.0846
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0056 0.0685 0.2016
Echinococcus multilocularis caspase 8 0.0056 0.0685 0.0663
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0014 0.0102 0.0079
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0139 0.1299
Schistosoma mansoni cpg binding protein 0.003 0.0328 0.0328
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0103 0.0859
Brugia malayi Cell death protein 3 precursor 0.0056 0.0685 0.1441
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0354 0.0331
Brugia malayi Probable DNA topoisomerase II 0.0014 0.0102 0.0171
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0054 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0056 0.0071
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0056 0.0071
Leishmania major DNA topoisomerase ii 0.0014 0.0102 0.0846
Loa Loa (eye worm) hypothetical protein 0.0014 0.0102 0.0171
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0056 0.0071
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0057 0.0301
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0056 0.0071
Loa Loa (eye worm) hypothetical protein 0.0052 0.0632 0.1326
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0014 0.0102 0.1105
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0014 0.0102 0.0209
Trichomonas vaginalis set domain proteins, putative 0.025 0.3382 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0069 0.0859 1
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0014 0.0102 0.1105
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0032 0.0084
Echinococcus granulosus hypothetical protein 0.0029 0.0306 0.0283
Echinococcus multilocularis caspase 2 0.0056 0.0685 0.0663
Schistosoma mansoni type V p-type atpase isoform 0.0009 0.0032 0.0032
Trichomonas vaginalis phospholipid-transporting ATPase, putative 0.0009 0.0032 0.0084
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0139 0.0116
Mycobacterium tuberculosis Conserved protein 0.0014 0.0102 0.1105
Echinococcus granulosus tumor protein p63 0.0356 0.485 0.4838
Plasmodium falciparum endoplasmin, putative 0.0042 0.0491 0.5556
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0191 0.1918
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0032 0.0084
Trichomonas vaginalis heat shock protein, putative 0.0069 0.0859 0.2532
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0191 0.1918
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0056 0.0071
Echinococcus granulosus expressed protein 0.0035 0.0397 0.0374
Leishmania major DNA polymerase eta, putative 0.0033 0.0368 0.4069
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0032 0.0009
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0012 0.0077 0.0116
Mycobacterium ulcerans heat shock protein 90 0.0055 0.0665 1
Echinococcus multilocularis cation transporting ATPase 13A3 0.0009 0.0032 0.0009
Onchocerca volvulus 0.0011 0.0056 0.0072
Trypanosoma cruzi heat shock protein 90, putative 0.0069 0.0859 1
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0543 0.0543
Trypanosoma cruzi heat shock protein 85, putative 0.0069 0.0859 1
Echinococcus multilocularis heat shock protein 90 0.0069 0.0859 0.0837
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0397 0.0814
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0014 0.0102 0.0291
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0056 0.0685 0.2016
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0056 0.0685 0.7892
Trichomonas vaginalis heat shock protein, putative 0.0055 0.0665 0.1959
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0139 0.0253
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0056 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0056 0.0071
Entamoeba histolytica heat shock protein 90, putative 0.0069 0.0859 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0055 0.0665 0.7659
Leishmania major heat shock protein, putative 0.0028 0.0298 0.3215
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0056 0.0685 0.2016
Loa Loa (eye worm) heat shock protein 75 0.0028 0.0298 0.0598
Trypanosoma brucei heat shock protein 84, putative 0.0028 0.0298 0.3215
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0014 0.0102 0.0079
Schistosoma mansoni cpg binding protein 0.0032 0.0352 0.0352
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0077 0.0077
Trichomonas vaginalis rotamase, putative 0.0035 0.0397 0.1164
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0209 0.2812 0.2795
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0014 0.0102 0.1105
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0042 0.049 0.1017
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0056 0.0033
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0009 0.0032 0.0009
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0452 0.1327
Schistosoma mansoni phosphoserine phosphatase 0.0009 0.0032 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0056 0.0071
Echinococcus granulosus intermediate filament protein 0.0028 0.0303 0.028
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0056 0.0033
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0056 0.0056
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0014 0.0102 0.1105
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0008 0.0023 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0397 0.1164
Entamoeba histolytica hypothetical protein 0.0038 0.0434 0.4867
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.012 0.021
Schistosoma mansoni cation-transporting atpase worm 0.0009 0.0032 0.0032
Trichomonas vaginalis receptor histidine kinase, putative 0.0014 0.0102 0.0291
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0014 0.0102 0.1105
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0056 0.0071
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0056 0.0056
Echinococcus granulosus caspase 0.0209 0.2812 0.2795
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0099 0.0075
Schistosoma mansoni ATPase 0.0009 0.0032 0.0032
Brugia malayi hypothetical protein 0.0038 0.0434 0.0896
Plasmodium falciparum metacaspase 1 0.0056 0.0685 0.7892
Loa Loa (eye worm) hypothetical protein 0.0011 0.0056 0.0071
Loa Loa (eye worm) hypothetical protein 0.0011 0.0056 0.0071
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0385 0.4273
Trypanosoma brucei developmentally regulated phosphoprotein 0.0014 0.0102 0.0846
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0014 0.0102 0.0741
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0303 0.0609
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0055 0.0665 0.0643
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0056 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0685 0.2016
Schistosoma mansoni heat shock protein 0.0028 0.0298 0.0298
Trypanosoma cruzi heat shock protein 85, putative 0.0055 0.0665 0.7659
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0054 0.0031
Onchocerca volvulus 0.0028 0.0303 0.0808
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0368 0.4069
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0023 0.0023
Schistosoma mansoni atpase class VI type 11c 0.0009 0.0032 0.0032
Trypanosoma cruzi DNA polymerase eta, putative 0.0047 0.0563 0.6422
Brugia malayi Pre-SET motif family protein 0.0032 0.0354 0.0721
Toxoplasma gondii heat shock protein 90, putative 0.0069 0.0859 1
Trichomonas vaginalis heat shock protein, putative 0.0055 0.0665 0.1959
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0032 0.0084
Schistosoma mansoni rotamase 0.0035 0.0397 0.0397
Plasmodium vivax DNA topoisomerase II, putative 0.0014 0.0102 0.0846
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0685 0.2016
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0014 0.0102 0.0846
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0032 0.0084
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0023 0.0023
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0354 0.3895
Onchocerca volvulus Cell death protein 3 homolog 0.0056 0.0685 0.1949
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0032 0.0084
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0099 0.0075
Leishmania major heat shock protein 83-1 0.0069 0.0859 1
Echinococcus granulosus dna polymerase kappa 0.002 0.0191 0.0168
Brugia malayi nuclear hormone receptor 0.0011 0.0056 0.0071
Trypanosoma brucei unspecified product 0.002 0.0191 0.1918
Giardia lamblia Grp94/Hsp90 0.0055 0.0665 0.7659
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0056 0.0056
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0056 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0103 0.0859
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0056 0.0033
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0139 0.0253
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0385 0.4273
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0191 0.0168
Plasmodium vivax hypothetical protein, conserved 0.0056 0.0685 0.7892
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0354 0.0354
Giardia lamblia Pms1-like protein 0.0014 0.0102 0.0846
Mycobacterium ulcerans two component sensor kinase MprB 0.0014 0.0102 0.1105
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0028 0.0298 0.0794
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0009 0.0032 0.0032
Brugia malayi isocitrate dehydrogenase 0.0017 0.0139 0.0253
Plasmodium falciparum DNA gyrase subunit B 0.0014 0.0102 0.0846
Leishmania major heat shock protein 83-1 0.0069 0.0859 1
Echinococcus multilocularis dna polymerase eta 0.0047 0.0563 0.0541
Loa Loa (eye worm) hypothetical protein 0.0047 0.0563 0.1176
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0057 0.0301
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0397 0.0814
Entamoeba histolytica hypothetical protein 0.0038 0.0434 0.4867
Echinococcus granulosus cation transporting ATPase 13A1 0.0009 0.0032 0.0009
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0014 0.0102 0.1105
Loa Loa (eye worm) hypothetical protein 0.0028 0.0303 0.0609
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0014 0.0102 0.0846
Trypanosoma brucei metacaspase MCA3 0.0056 0.0685 0.7892
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0009 0.0032 0.0009
Loa Loa (eye worm) hypothetical protein 0.0009 0.0032 0.0019
Loa Loa (eye worm) hypothetical protein 0.0014 0.0102 0.0171
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0056 0.0685 0.1441
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0385 0.4273
Mycobacterium tuberculosis Probable two component sensor kinase 0.0014 0.0102 0.1105
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0014 0.0102 0.0209
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0014 0.0102 0.1105
Trypanosoma brucei metacaspase 0.0056 0.0685 0.7892
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0023 0.0023
Trichomonas vaginalis endoplasmin, putative 0.0042 0.0491 0.1445
Loa Loa (eye worm) hypothetical protein 0.0011 0.0056 0.0071
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0191 0.2504
Schistosoma mansoni survival motor neuron protein 0.0051 0.0614 0.0614
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0032 0.0084
Schistosoma mansoni eyes absent homolog 0.0093 0.1197 0.1197
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0014 0.0102 0.0741
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0014 0.0102 0.1105
Trypanosoma brucei DNA topoisomerase ii 0.0014 0.0102 0.0846
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0014 0.0102 0.1105
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0139 0.1299
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0014 0.0102 0.1105
Plasmodium falciparum metacaspase-like protein 0.0056 0.0685 0.7892
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0014 0.0102 0.0846
Mycobacterium leprae Probable two-component sensor kinase 0.0014 0.0102 0.1105
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0191 0.1918
Echinococcus granulosus lamin dm0 0.0028 0.0303 0.028
Leishmania major DNA polymerase kappa, putative 0.002 0.0191 0.1918
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0815 0.0815
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0056 0.0056
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0191 0.1918
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0009 0.0032 0.0019
Loa Loa (eye worm) hypothetical protein 0.0028 0.0295 0.0593
Trypanosoma cruzi heat shock protein 85, putative 0.0069 0.0859 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0139 0.0116
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0056 0.0071
Leishmania major heat shock protein 83-1 0.0069 0.0859 1
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0056 0.0685 0.0685
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0014 0.0102 0.0846
Schistosoma mansoni heat shock protein 0.0069 0.0859 0.0859
Leishmania major heat shock protein 83-1 0.0069 0.0859 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0191 0.1918
Schistosoma mansoni coup transcription factor 0.0011 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0056 0.0685 0.1441
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0056 0.0685 0.2016
Echinococcus granulosus protein quaking 0.0029 0.0306 0.0283
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0056 0.0685 0.2016
Leishmania major heat shock protein 83-1 0.0069 0.0859 1
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0032 0.0009
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0014 0.0102 0.1105
Brugia malayi Hsp90 protein 0.0028 0.0298 0.0598
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0056 0.0071
Echinococcus multilocularis expressed protein 0.0035 0.0397 0.0374
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0028 0.0298 0.3215
Loa Loa (eye worm) hypothetical protein 0.0013 0.0091 0.0148
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.012 0.021
Trichomonas vaginalis rotamase, putative 0.0034 0.0385 0.113
Schistosoma mansoni DNA polymerase eta 0.0047 0.0563 0.0563
Schistosoma mansoni pyruvate dehydrogenase 0.0014 0.0102 0.0102
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0056 0.0033
Loa Loa (eye worm) hypothetical protein 0.0013 0.0091 0.0148
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0029 0.0029
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0014 0.0102 0.0291
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0056 0.0071
Echinococcus multilocularis lamin dm0 0.0028 0.0303 0.028
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0056 0.0033
Echinococcus multilocularis cation transporting ATPase 13A1 0.0009 0.0032 0.0009
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0014 0.0102 0.1105
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0191 0.1918
Plasmodium falciparum heat shock protein 90, putative 0.0028 0.0298 0.3215
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0191 0.1918
Loa Loa (eye worm) hypothetical protein 0.0093 0.1197 0.2558
Leishmania major heat shock protein 83-1 0.0069 0.0859 1
Brugia malayi ecdysteroid receptor 0.0011 0.0056 0.0071
Brugia malayi Na,K-ATPase alpha subunit 0.0009 0.0032 0.0019
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0056 0.0033
Echinococcus granulosus endoplasmin 0.0055 0.0665 0.0643
Leishmania major heat shock protein 83-1 0.0069 0.0859 1
Schistosoma mansoni intermediate filament proteins 0.0028 0.0303 0.0303
Trypanosoma brucei DNA polymerase eta, putative 0.0047 0.0563 0.6422
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0056 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0191 0.1918
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0014 0.0102 0.1105
Entamoeba histolytica heat shock protein 90, putative 0.0069 0.0859 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0354 0.0331
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0303 0.0609
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0055 0.0665 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0008 0.0023 0.0059
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0011 0.0057 0.0301
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0032 0.0084
Echinococcus multilocularis endoplasmin 0.0055 0.0665 0.0643
Trypanosoma brucei heat shock protein 90, putative 0.0069 0.0859 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0139 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0056 0.0071
Trypanosoma cruzi heat shock protein 85, putative 0.0069 0.0859 1
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0028 0.0298 0.0275
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0632 0.0632
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0014 0.0102 0.0846
Brugia malayi steroid hormone receptor 0.0011 0.0056 0.0071
Echinococcus granulosus phospholipid transporting ATPase VA 0.0009 0.0032 0.0009
Brugia malayi nuclear receptor NHR-88 0.0011 0.0056 0.0071
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0191 0.2504
Schistosoma mansoni hypothetical protein 0.0051 0.0614 0.0614
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0014 0.0102 0.1105
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0009 0.0032 0.0009
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0014 0.0102 0.0079
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0055 0.0665 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0102 0.0171
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0008 0.0023 0.0023
Onchocerca volvulus 0.025 0.3382 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0056 0.0071
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0191 0.1918
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0014 0.0102 0.0291
Onchocerca volvulus 0.003 0.0328 0.0885
Mycobacterium leprae Probable two component sensor kinase MprB 0.0014 0.0102 0.1105
Brugia malayi hypothetical protein 0.0009 0.0032 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0056 0.0071
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0012 0.0077 0.0054
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0014 0.0102 0.0079
Plasmodium vivax heat shock protein 90, putative 0.0028 0.0298 0.3215
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0434 0.0412
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0614 0.1287
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0139 0.1696
Loa Loa (eye worm) hypothetical protein 0.0014 0.0099 0.0164
Trypanosoma brucei unspecified product 0.0014 0.0103 0.0859
Trypanosoma brucei heat shock protein, putative 0.0069 0.0859 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0139 0.0139
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0032 0.0084
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0298 0.0871
Schistosoma mansoni cation-transporting ATPase 0.0009 0.0032 0.0032
Schistosoma mansoni caspase-7 (C14 family) 0.0209 0.2812 0.2812
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0354 0.0354
Echinococcus granulosus caspase 8 0.0056 0.0685 0.0663
Brugia malayi E1-E2 ATPase family protein 0.0009 0.0032 0.0019
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0053 0.0064
Echinococcus granulosus heat shock protein 90 0.0055 0.0665 0.0643
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0354 0.0354
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0056 0.0071

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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