Detailed information for compound 1444209

Basic information

Technical information
  • TDR Targets ID: 1444209
  • Name: N-(2-methoxy-5-methylphenyl)-1,3-dioxo-2-(pyr idin-4-ylmethyl)isoindole-5-carboxamide
  • MW: 401.415 | Formula: C23H19N3O4
  • H donors: 1 H acceptors: 4 LogP: 2.49 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1NC(=O)c1ccc2c(c1)C(=O)N(C2=O)Cc1ccncc1)C
  • InChi: 1S/C23H19N3O4/c1-14-3-6-20(30-2)19(11-14)25-21(27)16-4-5-17-18(12-16)23(29)26(22(17)28)13-15-7-9-24-10-8-15/h3-12H,13H2,1-2H3,(H,25,27)
  • InChiKey: DGXXKWDMRQEGGW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-methoxy-5-methyl-phenyl)-1,3-dioxo-2-(4-pyridylmethyl)isoindoline-5-carboxamide
  • N-(2-methoxy-5-methylphenyl)-1,3-dioxo-2-(4-pyridylmethyl)-5-isoindolinecarboxamide
  • 1,3-diketo-N-(2-methoxy-5-methyl-phenyl)-2-(4-pyridylmethyl)isoindoline-5-carboxamide
  • N-(2-methoxy-5-methyl-phenyl)-1,3-dioxo-2-(pyridin-4-ylmethyl)isoindole-5-carboxamide
  • T5374852
  • ZINC06785424

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii hypothetical protein 0.0043 0.0765 0.6522
Schistosoma mansoni cpg binding protein 0.0029 0.0486 0.0486
Echinococcus multilocularis GPCR, family 2 0.0031 0.0514 0.0514
Entamoeba histolytica hypothetical protein 0.0023 0.0359 0.4694
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0149 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0018 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0018 0.0238
Brugia malayi Delta5 fatty acid desaturase 0.0063 0.1173 0.2473
Trypanosoma cruzi GUP1, putative 0.0043 0.0765 0.0787
Loa Loa (eye worm) hypothetical protein 0.0029 0.0468 0.053
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0043 0.0765 0.0765
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0018 0.0238
Mycobacterium ulcerans transmembrane alkane 1-monooxygenase AlkB 0.0063 0.1173 0.5
Echinococcus multilocularis Peptidase M, neutral zinc metallopeptidases, zinc binding site 0.0063 0.1173 0.1173
Mycobacterium ulcerans linoleoyl-CoA desaturase, DesA3_2 0.0063 0.1173 0.5
Schistosoma mansoni ran 0.0021 0.0316 0.0316
Trypanosoma cruzi delta-4 fatty acid desaturase, putative 0.0063 0.1173 0.1501
Leishmania major hypothetical protein, conserved 0.0024 0.0386 0.0641
Trypanosoma cruzi cytochrome b5-dependent oleate desaturase 0.0063 0.1173 0.1501
Echinococcus multilocularis cpg binding protein 0.0029 0.0486 0.0486
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0043 0.0765 0.0765
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0018 0.0238
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0043 0.0765 0.0765
Trypanosoma cruzi glycerol uptake protein, putative 0.0043 0.0765 0.0787
Leishmania major hypothetical protein, conserved 0.0043 0.0765 0.127
Schistosoma mansoni cpg binding protein 0.0028 0.0453 0.0453
Schistosoma mansoni fatty acid desaturase 0.0063 0.1173 0.1173
Trypanosoma brucei cytochrome b5-dependent oleate desaturase 0.0063 0.1173 0.1947
Plasmodium falciparum stearoyl-CoA desaturase 0.024 0.4745 1
Leishmania major delta-5 fatty acid desaturase 0.0063 0.1173 0.1947
Loa Loa (eye worm) hypothetical protein 0.0012 0.0139 0.0158
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.1743 0.1971
Loa Loa (eye worm) Smad1 0.0008 0.0051 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0018 0.0238
Echinococcus granulosus o acyltransferase membrane bound domain 0.0043 0.0765 0.0765
Mycobacterium ulcerans linoleoyl-CoA desaturase, DesA3 0.0063 0.1173 0.5
Schistosoma mansoni zinc finger protein 0.0043 0.0765 0.0765
Brugia malayi Fatty acid desaturase family protein 0.0063 0.1173 0.2473
Schistosoma mansoni importin beta-1 0.0029 0.0468 0.0468
Onchocerca volvulus 0.0303 0.6027 1
Schistosoma mansoni sterol O-acyltransferase 1 0.0443 0.8844 0.8844
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0453 0.0513
Echinococcus multilocularis musashi 0.0026 0.0426 0.0426
Schistosoma mansoni lamin 0.0026 0.0426 0.0426
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.1238 0.2608
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0677 0.1428
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0359 0.4694
Brugia malayi MH2 domain containing protein 0.0116 0.2238 0.4716
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0043 0.0765 0.0765
Loa Loa (eye worm) hypothetical protein 0.0012 0.0139 0.0158
Trypanosoma brucei glycerol uptake protein, putative 0.0043 0.0765 0.127
Leishmania major delta-12 fatty acid desaturase 0.0063 0.1173 0.1947
Trypanosoma brucei sphingolipid delta 4 desaturase, putative 0.0063 0.1173 0.1947
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0359 0.4694
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0018 0.0238
Leishmania major glycerol uptake protein, putative 0.0043 0.0765 0.127
Schistosoma mansoni smad1 5 8 and 0.0008 0.0051 0.0051
Trichomonas vaginalis transmembrane protein nessy, putative 0.0043 0.0765 1
Echinococcus granulosus snurportin 1 0.0305 0.6058 0.6058
Schistosoma mansoni hypothetical protein 0.0031 0.0514 0.0514
Trypanosoma cruzi fatty acid desaturase, putative 0.0063 0.1173 0.1501
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.1861 0.3922
Leishmania major fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative 0.0063 0.1173 0.1947
Entamoeba histolytica vacuolar protein sorting 26 0.0043 0.0765 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0316 0.0357
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0514 0.0514
Loa Loa (eye worm) hypothetical protein 0.0043 0.0765 0.0865
Schistosoma mansoni intermediate filament proteins 0.0026 0.0426 0.0426
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.2809 0.592
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0749 0.6384
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0018 0.0238
Trypanosoma brucei delta-4 fatty acid desaturase 0.0063 0.1173 0.1947
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0514 0.0514
Brugia malayi intermediate filament protein 0.0026 0.0426 0.0899
Entamoeba histolytica Ran family GTPase 0.0021 0.0316 0.4128
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0043 0.0765 0.0765
Brugia malayi MH2 domain containing protein 0.0008 0.0051 0.0107
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.2238 0.253
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0178 0.0201
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0051 0.0057
Echinococcus granulosus sterol O acyltransferase 1 0.0443 0.8844 0.8844
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0386 0.0641
Leishmania major importin beta-1 subunit, putative 0.0023 0.0359 0.0596
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0043 0.0765 0.0865
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0043 0.0765 0.0765
Loa Loa (eye worm) fatty acid desaturase 0.0063 0.1173 0.1327
Loa Loa (eye worm) fatty acid desaturase 0.0063 0.1173 0.1327
Mycobacterium tuberculosis Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f 0.0063 0.1173 0.5
Leishmania major fatty acid desaturase, putative 0.0063 0.1173 0.1947
Loa Loa (eye worm) hypothetical protein 0.0026 0.0426 0.0482
Leishmania major stearic acid desaturase, putative 0.0303 0.6027 1
Brugia malayi diacylglycerol acyltransferase 0.0043 0.0765 0.1613
Brugia malayi MBOAT family protein 0.0043 0.0765 0.1613
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1743 0.1743
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0065 0.0073
Loa Loa (eye worm) hypothetical protein 0.0063 0.1173 0.1327
Echinococcus multilocularis smad 0.0008 0.0051 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0018 0.0238
Echinococcus multilocularis Peptidase M, neutral zinc metallopeptidases, zinc binding site 0.0063 0.1173 0.1173
Loa Loa (eye worm) hypothetical protein 0.0097 0.1861 0.2104
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.1743 0.1743
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0043 0.0765 0.0765
Leishmania major fatty-acid desaturase, putative 0.0303 0.6027 1
Schistosoma mansoni lamin 0.0026 0.0426 0.0426
Brugia malayi Fatty acid desaturase family protein 0.0063 0.1173 0.2473
Leishmania major glycerol uptake protein, putative 0.0043 0.0765 0.127
Brugia malayi hypothetical protein 0.0016 0.0211 0.0444
Trypanosoma cruzi delta-4 fatty acid desaturase, putative 0.0063 0.1173 0.1501
Loa Loa (eye worm) hypothetical protein 0.0013 0.0149 0.0169
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.2809 0.2809
Leishmania major glycerol uptake protein, putative 0.0043 0.0765 0.127
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0359 0.0076
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0018 0.0238
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0316 0.0666
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0386 0.0814
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0316 0.0666
Echinococcus granulosus GPCR family 2 0.0031 0.0514 0.0514
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0468 0.0777
Schistosoma mansoni hypothetical protein 0.0011 0.0113 0.0113
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0051 0.0057
Brugia malayi F/Y-rich N-terminus family protein 0.0008 0.0063 0.0132
Loa Loa (eye worm) hypothetical protein 0.0043 0.0765 0.0865
Loa Loa (eye worm) MBOAT family protein 0.0043 0.0765 0.0865
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0749 0.9787
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0018 0.0238
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0426 0.0899
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0018 0.0238
Schistosoma mansoni smad1 5 8 and 0.0008 0.0051 0.0051
Echinococcus multilocularis geminin 0.05 1 1
Loa Loa (eye worm) hypothetical protein 0.0399 0.797 0.9011
Leishmania major GTP-binding protein, putative 0.0021 0.0316 0.0524
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0443 0.8844 1
Echinococcus granulosus Sphingolipid delta4 desaturase DES1 0.0063 0.1173 0.1173
Echinococcus granulosus importin subunit beta 1 0.0029 0.0468 0.0468
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0051 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0765 1
Brugia malayi MH1 domain containing protein 0.0008 0.0051 0.0107
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0018 0.0238
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.7906 0.7906
Onchocerca volvulus 0.0043 0.0765 0.0605
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0316 0.0524
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0316 0.0666
Onchocerca volvulus 0.0303 0.6027 1
Trypanosoma cruzi glycerol uptake protein, putative 0.0043 0.0765 0.0787
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.1743 0.3674
Echinococcus multilocularis sterol O acyltransferase 1 0.0443 0.8844 0.8844
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.1861 0.3922
Mycobacterium ulcerans hypothetical protein 0.0063 0.1173 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0386 0.0123
Leishmania major glycerol uptake protein, putative 0.0043 0.0765 0.127
Loa Loa (eye worm) acetyltransferase 0.0144 0.2809 0.3176
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.2238 0.253
Trypanosoma cruzi fatty acid desaturase, putative 0.024 0.4745 0.7754
Schistosoma mansoni hypothetical protein 0.05 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1743 0.1743
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0043 0.0765 0.0765
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0514 0.1084
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0031 0.0031
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0316 0.0316
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0514 0.0581
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0677 0.8853
Echinococcus granulosus cpg binding protein 0.0029 0.0486 0.0486
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0031 0.0031
Schistosoma mansoni Smad4 0.0008 0.0051 0.0051
Mycobacterium ulcerans hypothetical protein 0.0063 0.1173 0.5
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0043 0.0765 0.0765
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.2727 0.2727
Brugia malayi acyl-CoA desaturase 0.024 0.4745 1
Schistosoma mansoni hypothetical protein 0.0305 0.6058 0.6058
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0031 0.0031
Echinococcus granulosus Fatty acid desaturase type 1 0.0063 0.1173 0.1173
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0018 0.0238
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1084 0.1084
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0468 0.3993
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0749 0.1578
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0305 0.6058 0.685
Echinococcus multilocularis Fatty acid desaturase, type 1 0.0063 0.1173 0.1173
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0178 0.0374
Echinococcus granulosus o acyltransferase membrane bound domain 0.0043 0.0765 0.0765
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0051 0.0051
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0514 0.0514
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0018 0.0238
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0749 0.9787
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0043 0.0765 1
Echinococcus multilocularis snurportin 1 0.0305 0.6058 0.6058
Brugia malayi Hhat protein 0.0043 0.0765 0.1613
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.1743 0.1743
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0043 0.0765 0.0765
Schistosoma mansoni hypothetical protein 0.0031 0.0514 0.0514
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0149 0.0149
Entamoeba histolytica hypothetical protein 0.0043 0.0765 1
Schistosoma mansoni hypothetical protein 0.0396 0.7906 0.7906
Brugia malayi MBOAT family protein 0.0043 0.0765 0.1613
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0359 0.4694
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0043 0.0765 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.1861 0.2104
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0043 0.0765 0.0865
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0043 0.0765 0.6522
Trypanosoma cruzi GUP1, putative 0.0043 0.0765 0.0787
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0051 0.0051
Schistosoma mansoni hypothetical protein 0.0031 0.0514 0.0514
Leishmania major fatty acid desaturase, putative 0.0063 0.1173 0.1947
Schistosoma mansoni hypothetical protein 0.0043 0.0765 0.0765
Trypanosoma brucei glycerol uptake protein, putative 0.0043 0.0765 0.127
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0386 0.0814
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.1028 0.8765
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0065 0.0065
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0043 0.0765 0.0765
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0043 0.0765 0.1613
Echinococcus granulosus lamin 0.0026 0.0426 0.0426
Loa Loa (eye worm) hypothetical protein 0.0026 0.0417 0.0471
Mycobacterium ulcerans electron transfer protein FdxB 0.0063 0.1173 0.5
Brugia malayi MBOAT family protein 0.0043 0.0765 0.1613
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.1743 0.1743
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0468 0.0777
Plasmodium vivax importin-beta 2, putative 0.0029 0.0468 0.0987
Leishmania major delta-6 fatty acid desaturase 0.0063 0.1173 0.1947
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0316 0.0316
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0749 0.6384
Toxoplasma gondii sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein 0.0063 0.1173 1
Treponema pallidum alginate O-acetylation protein (algI) 0.0043 0.0765 0.5
Loa Loa (eye worm) hypothetical protein 0.0067 0.1238 0.1399
Echinococcus granulosus o acyltransferase membrane bound domain 0.0043 0.0765 0.0765
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0468 0.0468
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0018 0.0238
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.2809 0.2809
Leishmania major glycerol uptake protein, putative 0.0043 0.0765 0.127
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0113 0.0113
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0043 0.0765 0.6522
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0749 0.0749
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0765 1
Echinococcus multilocularis lamin dm0 0.0026 0.0426 0.0426
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0043 0.0765 0.0765
Schistosoma mansoni ran 0.0021 0.0316 0.0316
Mycobacterium tuberculosis Probable conserved membrane protein 0.0063 0.1173 0.5
Loa Loa (eye worm) hypothetical protein 0.0043 0.0765 0.0865
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0386 0.0814
Loa Loa (eye worm) hhat protein 0.0043 0.0765 0.0865
Mycobacterium ulcerans linoleoyl-CoA desaturase, DesA3 0.0063 0.1173 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1743 0.1743
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0031 0.0514 0.0581
Leishmania major fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative 0.0063 0.1173 0.1947
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0031 0.0031
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0386 0.3293
Trypanosoma brucei delta-6 fatty acid desaturase, putative 0.0063 0.1173 0.1947
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0386 0.0123
Leishmania major fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative 0.0063 0.1173 0.1947
Brugia malayi MBOAT family protein 0.0043 0.0765 0.1613
Loa Loa (eye worm) MBOAT family protein 0.0043 0.0765 0.0865
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0043 0.0765 1
Echinococcus multilocularis lamin 0.0026 0.0426 0.0426
Schistosoma mansoni cpg binding protein 0.0029 0.0486 0.0486
Schistosoma mansoni smad1 5 8 and 0.0008 0.0051 0.0051
Loa Loa (eye worm) MBOAT family protein 0.0043 0.0765 0.0865
Loa Loa (eye worm) hhat protein 0.0043 0.0765 0.0865
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0765 1
Brugia malayi MBOAT family protein 0.0043 0.0765 0.1613
Schistosoma mansoni smad 0.0008 0.0051 0.0051
Brugia malayi MH1 domain containing protein 0.0008 0.0051 0.0107
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0677 1
Leishmania major fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative 0.0063 0.1173 0.1947
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0018 0.0238
Brugia malayi CXXC zinc finger family protein 0.0028 0.0453 0.0956
Brugia malayi hypothetical protein 0.0024 0.0386 0.0814
Echinococcus granulosus smad 0.0008 0.0051 0.0051
Trypanosoma cruzi fatty acid desaturase, putative 0.024 0.4745 0.7754
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.1743 0.1743
Mycobacterium tuberculosis Possible electron transfer protein FdxB 0.0063 0.1173 0.5
Trichomonas vaginalis ran, putative 0.0021 0.0316 0.4128
Schistosoma mansoni hypothetical protein 0.05 1 1
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0043 0.0765 0.0765
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0065 0.0065
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0426 0.0482
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0018 0.0238
Plasmodium vivax stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative 0.024 0.4745 1
Trypanosoma brucei fatty acid desaturase, putative 0.0303 0.6027 1
Echinococcus multilocularis Smad4 0.0008 0.0051 0.0051
Entamoeba histolytica hypothetical protein, conserved 0.0043 0.0765 1
Brugia malayi RNA, U transporter 1 0.0081 0.1534 0.3232
Brugia malayi Importin beta-1 subunit 0.0029 0.0468 0.0987
Trichomonas vaginalis porcupine, putative 0.0043 0.0765 1
Echinococcus granulosus dnaJ subfamily B 0.0396 0.7906 0.7906
Loa Loa (eye worm) hypothetical protein 0.0024 0.0386 0.0437
Trypanosoma cruzi fatty acid desaturase, putative 0.0303 0.6027 1
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0043 0.0765 0.1613
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0043 0.0765 0.0765
Echinococcus granulosus intermediate filament protein 0.0026 0.0426 0.0426
Schistosoma mansoni hypothetical protein 0.0067 0.1238 0.1238
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0514 0.0514
Loa Loa (eye worm) acyl-CoA desaturase 0.024 0.4745 0.5365
Loa Loa (eye worm) FAT-3 protein 0.0063 0.1173 0.1327
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0051 0.0051
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0426 0.0482
Plasmodium falciparum importin beta, putative 0.0029 0.0468 0.0987
Schistosoma mansoni hypothetical protein 0.0031 0.0514 0.0514
Onchocerca volvulus 0.0028 0.0453 0.0048
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0043 0.0765 0.0765
Trichomonas vaginalis helicase, putative 0.0006 0.0018 0.0238
Brugia malayi MH2 domain containing protein 0.0008 0.0051 0.0107
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0043 0.0765 0.0765
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0043 0.0765 0.0765
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0043 0.0765 0.0765
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0051 0.0051
Echinococcus granulosus Smad4 0.0008 0.0051 0.0051
Echinococcus granulosus lamin dm0 0.0026 0.0426 0.0426
Brugia malayi Smad1 0.0008 0.0051 0.0107
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0514 0.1084
Onchocerca volvulus 0.0063 0.1173 0.1333
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0043 0.0765 0.0765
Leishmania major delta-4 fatty acid desaturase 0.0063 0.1173 0.1947
Trypanosoma cruzi sphingolipid delta 4 desaturase, putative 0.0063 0.1173 0.1501
Trypanosoma cruzi glycerol uptake protein, putative 0.0043 0.0765 0.0787
Trypanosoma cruzi fatty acid desaturase, putative 0.0063 0.1173 0.1501
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0316 0.2693

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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