Detailed information for compound 1454347

Basic information

Technical information
  • TDR Targets ID: 1454347
  • Name: (E)-3-[(4-methoxyphenyl)amino]-1-(4-pyrimidin -2-yloxyphenyl)prop-2-en-1-one
  • MW: 347.367 | Formula: C20H17N3O3
  • H donors: 1 H acceptors: 3 LogP: 4.05 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)N/C=C/C(=O)c1ccc(cc1)Oc1ncccn1
  • InChi: 1S/C20H17N3O3/c1-25-17-9-5-16(6-10-17)21-14-11-19(24)15-3-7-18(8-4-15)26-20-22-12-2-13-23-20/h2-14,21H,1H3/b14-11+
  • InChiKey: VXFGKNVXDPCMHO-SDNWHVSQSA-N  


Substructure search Similarity search

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Synonyms

  • 3-[(4-methoxyphenyl)amino]-1-(4-pyrimidin-2-yloxyphenyl)prop-2-en-1-one
  • (E)-3-[(4-methoxyphenyl)amino]-1-[4-(2-pyrimidinyloxy)phenyl]prop-2-en-1-one
  • 3-[(4-methoxyphenyl)amino]-1-[4-(2-pyrimidinyloxy)phenyl]prop-2-en-1-one
  • ZINC01398426
  • (E)-3-(4-methoxyanilino)-1-[4-(2-pyrimidinyloxy)phenyl]-2-propen-1-one
  • MLS000326493
  • SMR000179115
  • 7N-094

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0033 0.0054 0.0083
Onchocerca volvulus 0.0026 0.0031 0.0639
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0012 0.0018
Echinococcus multilocularis muscleblind protein 0.0145 0.0396 0.0608
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0018
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0307 0.0472
Schistosoma mansoni hypothetical protein 0.004 0.0074 0.0114
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.082 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.025 0.0383
Treponema pallidum fructose-bisphosphate aldolase 0.0284 0.082 0.6619
Loa Loa (eye worm) hypothetical protein 0.0035 0.006 0.0092
Brugia malayi beta-lactamase family protein 0.0035 0.006 0.0092
Schistosoma mansoni intermediate filament proteins 0.0026 0.0033 0.0051
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0048
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.006 0.0092
Onchocerca volvulus 0.0026 0.0031 0.0639
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.082 1
Schistosoma mansoni hypothetical protein 0.0165 0.0456 0.07
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0307 0.0472
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.006 0.0385
Schistosoma mansoni hypothetical protein 0.0033 0.0054 0.0083
Mycobacterium tuberculosis Conserved protein 0.0035 0.006 0.0045
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.2491 0.3825
Onchocerca volvulus 0.0035 0.006 0.1584
Schistosoma mansoni hypothetical protein 0.2154 0.6513 1
Echinococcus granulosus intermediate filament protein 0.0026 0.0033 0.0051
Schistosoma mansoni hypothetical protein 0.2154 0.6513 1
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0031 0.0048
Echinococcus granulosus peroxidasin 0.0026 0.0031 0.0048
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0031 0.0048
Loa Loa (eye worm) hypothetical protein 0.0096 0.0245 0.0376
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0031 0.0048
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.006 0.0092
Mycobacterium leprae Probable lipase LipE 0.0035 0.006 0.0059
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0078 0.0121
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0048
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.004 0.0204
Loa Loa (eye worm) acetyltransferase 0.0141 0.0383 0.0588
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.006 0.0092
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.082 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.006 0.711
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0371 0.0569
Onchocerca volvulus Huntingtin homolog 0.0119 0.0316 1
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0245 0.0376
Schistosoma mansoni rab6-interacting 0.0019 0.0012 0.0018
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.082 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.082 1
Chlamydia trachomatis recombinase RecA 0.0105 0.0273 0.2358
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.006 0.0045
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.006 0.0092
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0101 0.0155
Schistosoma mansoni lamin 0.0026 0.0033 0.0051
Echinococcus multilocularis RUN 0.0019 0.0012 0.0018
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0376 0.1099 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.004 0.0204
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.006 0.0092
Leishmania major hypothetical protein, conserved 0.0035 0.006 1
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.006 0.0045
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0048
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.004 0.0204
Brugia malayi Doublecortin family protein 0.0019 0.0012 0.0018
Onchocerca volvulus Dual oxidase homolog 0.0026 0.0031 0.0639
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0018
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.004 0.0204
Echinococcus multilocularis protein dispatched 1 0.0047 0.0096 0.0148
Onchocerca volvulus 0.0026 0.0033 0.0705
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.004 0.0204
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0031 0.0048
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0018 0.0987
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0028
Brugia malayi hypothetical protein 0.0035 0.006 0.0092
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0031 0.0048
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.008 0.0122
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.0383 0.0588
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.008 0.0258
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0028
Schistosoma mansoni polycystin 1-related 0.0019 0.0012 0.0018
Mycobacterium tuberculosis Conserved protein 0.0035 0.006 0.0045
Loa Loa (eye worm) hypothetical protein 0.0041 0.0078 0.0121
Brugia malayi hypothetical protein 0.0026 0.0031 0.0048
Loa Loa (eye worm) hypothetical protein 0.0035 0.006 0.0092
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0012 0.0018
Loa Loa (eye worm) hypothetical protein 0.0119 0.0316 0.0486
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0101 0.0155
Schistosoma mansoni lipoxygenase 0.008 0.0198 0.0304
Onchocerca volvulus Huntingtin homolog 0.0119 0.0316 1
Echinococcus multilocularis geminin 0.0165 0.0456 0.07
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0789 0.2357 0.3619
Brugia malayi beta-lactamase family protein 0.0035 0.006 0.0092
Echinococcus multilocularis protein patched 0.0041 0.0078 0.0121
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.082 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.006 1
Loa Loa (eye worm) hypothetical protein 0.0145 0.0396 0.0608
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0069 1
Echinococcus multilocularis expressed conserved protein 0.009 0.0227 0.0349
Brugia malayi beta-lactamase 0.0035 0.006 0.0092
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0048
Schistosoma mansoni hypothetical protein 0.004 0.0074 0.0114
Schistosoma mansoni peroxidasin 0.0026 0.0031 0.0048
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.006 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.004 0.0062
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0054 0.0083
Onchocerca volvulus 0.0029 0.004 0.0943
Mycobacterium ulcerans hypothetical protein 0.0029 0.004 0.0204
Giardia lamblia Fructose-bisphosphate aldolase 0.0284 0.082 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.004 0.0026
Onchocerca volvulus 0.0035 0.006 0.1584
Brugia malayi hypothetical protein 0.0119 0.0316 0.0486
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115 0.0303 0.0465
Schistosoma mansoni hypothetical protein 0.004 0.0074 0.0114
Echinococcus granulosus lamin 0.0026 0.0033 0.0051
Echinococcus granulosus RUN 0.0019 0.0012 0.0018
Entamoeba histolytica hypothetical protein 0.0035 0.006 0.025
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0376 0.1099 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.0635 0.0621
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0018 0.1168
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.0062
Brugia malayi AMP-binding enzyme family protein 0.0029 0.004 0.0062
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0048
Loa Loa (eye worm) hypothetical protein 0.0049 0.0101 0.0155
Echinococcus granulosus indoleamine 23 dioxygenase 2 0.2154 0.6513 1
Schistosoma mansoni rab6-interacting 0.0019 0.0012 0.0018
Mycobacterium ulcerans lipase LipD 0.0035 0.006 0.0385
Onchocerca volvulus Peroxidase homolog 0.0026 0.0031 0.0639
Mycobacterium leprae Conserved hypothetical protein 0.1109 0.3331 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.0383 0.0588
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0033 0.0051
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.008 0.0258
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.082 1
Entamoeba histolytica hypothetical protein 0.0035 0.006 0.025
Loa Loa (eye worm) hypothetical protein 0.0035 0.006 0.0092
Brugia malayi Blistered cuticle protein 3 0.0026 0.0031 0.0048
Brugia malayi intermediate filament protein 0.0026 0.0033 0.0051
Brugia malayi hypothetical protein 0.0019 0.0012 0.0018
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0048
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.006 0.0045
Loa Loa (eye worm) beta-lactamase 0.0035 0.006 0.0092
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0012 0.0018
Mycobacterium tuberculosis Conserved protein 0.0035 0.006 0.0045
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.006 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.082 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0018 0.0004
Entamoeba histolytica hypothetical protein 0.0035 0.006 0.025
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.006 0.0092
Echinococcus granulosus lamin dm0 0.0026 0.0033 0.0051
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0012 0.0018
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0048
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.0376 0.1021
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.0062
Schistosoma mansoni peroxidasin 0.0026 0.0031 0.0048
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.3028 0.9174 0.9173
Loa Loa (eye worm) hypothetical protein 0.005 0.0107 0.0164
Echinococcus multilocularis lamin dm0 0.0026 0.0033 0.0051
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0031 0.0048
Loa Loa (eye worm) hypothetical protein 0.0035 0.006 0.0092
Loa Loa (eye worm) hypothetical protein 0.0035 0.006 0.0092
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.0376 0.0362
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0048
Echinococcus multilocularis lamin 0.0026 0.0033 0.0051
Mycobacterium ulcerans beta-lactamase 0.0035 0.006 0.0385
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0031 0.0639
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0028
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0048
Echinococcus multilocularis muscleblind protein 1 0.0145 0.0396 0.0608
Onchocerca volvulus Peroxidase homolog 0.0026 0.0031 0.0639
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.006 0.0045
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.082 1
Brugia malayi Muscleblind-like protein 0.0145 0.0396 0.0608
Entamoeba histolytica hypothetical protein 0.0035 0.006 0.025
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0031 0.0048
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0031 0.0639
Schistosoma mansoni hypothetical protein 0.004 0.0074 0.0114
Brugia malayi CHE-14 protein 0.0041 0.0078 0.0121
Schistosoma mansoni Replicative DNA helicase 0.0376 0.1099 0.1687
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.2491 0.3825
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0078 0.0244
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0101 0.0155
Brugia malayi AMP-binding enzyme family protein 0.0029 0.004 0.0062
Schistosoma mansoni hypothetical protein 0.0035 0.006 0.0092
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0245 0.0376
Echinococcus granulosus muscleblind protein 0.0145 0.0396 0.0608
Schistosoma mansoni hypothetical protein 0.0019 0.0012 0.0018
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0245 0.2626
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0033 0.0051
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0028
Schistosoma mansoni loxhd1 0.0019 0.0012 0.0018
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.008 1
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.006 0.0045
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.082 1
Loa Loa (eye worm) twinkle helicase 0.0107 0.0281 0.0431
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.004 0.0204
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0012 0.0018
Onchocerca volvulus 0.0026 0.0033 0.0705
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0049
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.004 0.0026
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0012 0.0018
Loa Loa (eye worm) hypothetical protein 0.0026 0.0033 0.0051
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.006 0.0092
Onchocerca volvulus 0.0026 0.0031 0.0639
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0028
Loa Loa (eye worm) hypothetical protein 0.0035 0.006 0.0092
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.006 0.0092
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.006 0.0385
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.0062
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115 0.0303 0.0465
Echinococcus multilocularis peroxidasin 0.0026 0.0031 0.0048
Brugia malayi MH2 domain containing protein 0.0116 0.0307 0.0472
Loa Loa (eye worm) hypothetical protein 0.0119 0.0316 0.0486
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.006 0.0045
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.006 0.0045
Treponema pallidum replicative DNA helicase (dnaB) 0.0376 0.1099 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0069 0.0367
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.0376 0.3314
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0012 0.0018
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0376 0.1099 0.3217
Onchocerca volvulus 0.0035 0.006 0.1584
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0031 0.0048
Schistosoma mansoni patched 1 0.0041 0.0078 0.0121
Loa Loa (eye worm) indoleamine 2,3-dioxygenase 0.2154 0.6513 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.004 0.0204
Echinococcus multilocularis musashi 0.0026 0.0033 0.0051
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0048
Chlamydia trachomatis replicative DNA helicase 0.0376 0.1099 1
Brugia malayi Peroxidasin 0.0026 0.0031 0.0048
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0245 0.0376
Brugia malayi hypothetical protein 0.0019 0.0012 0.0018
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.037 0.0569
Brugia malayi indoleamine 2,3-dioxygenase 0.2154 0.6513 1
Echinococcus granulosus expressed conserved protein 0.009 0.0227 0.0349
Schistosoma mansoni lamin 0.0026 0.0033 0.0051
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.0031 0.0639
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0033 0.0051
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.008 1
Mycobacterium ulcerans recombinase A 0.0105 0.0273 0.2358
Mycobacterium ulcerans hypothetical protein 0.0035 0.006 0.0385
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0078 0.0121
Mycobacterium leprae conserved hypothetical protein 0.0035 0.006 0.0059
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.006 0.0092
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0078 0.0121
Schistosoma mansoni hypothetical protein 0.0165 0.0456 0.07
Echinococcus granulosus microtubule associated protein 2 0.0833 0.2491 0.3825
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.0383 0.0588
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0031 0.0048
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0105 0.0273 0.0707
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0048
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.037 0.0569
Loa Loa (eye worm) hypothetical protein 0.0145 0.0396 0.0608
Schistosoma mansoni lipoxygenase 0.0115 0.0303 0.0465
Echinococcus granulosus geminin 0.0165 0.0456 0.07
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0048
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 0.2154 0.6513 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.008 1
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0031 0.0048
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0078 0.0121
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0048
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0048

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.6944 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (binding) = 3.1623 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 32.6427 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1412.5375 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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